infectious syphilis in england: changing epidemiology and new prevention needs
DESCRIPTION
Infectious Syphilis in England: Changing epidemiology and new prevention needs. Dr Kevin Fenton Consultant Epidemiologist HIV/STI Division PHLS Communicable Disease Surveillance Centre. Outline. Recent trends in syphilis in England and Wales Resurgence of syphilis in London - PowerPoint PPT PresentationTRANSCRIPT
Infectious Syphilis in England:Changing epidemiology and
new prevention needs
Dr Kevin Fenton
Consultant Epidemiologist
HIV/STI Division
PHLS Communicable Disease Surveillance Centre
Outline
• Recent trends in syphilis in England and Wales
• Resurgence of syphilis in London
• New national enhanced surveillance requirements for infectious syphilis
Males
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1995 1996 1997 1998 1999 2000
rate
per
100
,000
pop
ulat
ion
EnglandWalesScotland**N Ireland***
Females
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1995 1996 1997 1998 1999 2000
rate
per
100
,000
pop
ulat
ion
Recent epidemiology: Rates of infectious syphilis by country.
PHLS (England, Wales & Northern Ireland), DHSS&PS (Northern Ireland) andScottish ISD(D)5 Collaborative Group (ISD, SCIEH and MSSVD)
PHLS (England, Wales & Northern Ireland), DHSS&PS (Northern Ireland) andScottish ISD(D)5 Collaborative Group (ISD, SCIEH and MSSVD)
Recent epidemiology: New diagnoses of infectious syphilis by sex, country and English region; 2000
KeyRate per 100 000 population
A: 0.00 - 0.15
B: 0.16 - 0.30
C: 0.31 - 0.45
D: 0.46 - 0.60
E: 0.61 - 0.75
F: 0.76+
MalesOverall UK rate: 0.55
FemalesOverall UK rate: 0.19
A
A
F
AB
B
C
C
C
E
F
A
AA
A
A
A
B
B
C
A
D
Recent epidemiology:Laboratory reports of infectious syphilis by probable region of acquisition: males England and Wales, 1994 to 1999
0
10
20
30
40
50
1994 1995 1996 1997 1998 1999
Year
Num
ber o
f lab
orat
ory
repo
rts
Africa
Asia
Europe
UK
PHLS (England, Wales & Northern Ireland), DHSS&PS (Northern Ireland) andScottish ISD(D)5 Collaborative Group (ISD, SCIEH and MSSVD)
The London enhanced surveillance programme for infectious syphilis
London enhanced surveillance:Key aims and objectives
• AIM:
– To improve our understanding of the distribution and determinants of infectious syphilis in London
• Objectives
– To characterise the recent cluster of cases
– To identify key social and sexual networks;
– To investigate the relationship between HIV and syphilis
London enhanced surveillance:Methodology
• Health Adviser led, established 1 August 2001
• 36 GUM clinics in the London region
• Diagnoses of infectious syphilis:
– Primary, Secondary and Early latent
– Retrospective collection from 1st April – 31st July 2001
– Prospective collection
Data collection
form for the London
enhanced surveillance programme for syphilis
London enhanced surveillance:Data analysis presented in this report
• Data analysis from 1st April 2001 to 12th April 2002
• Total number or reports: 393
– Number of Males: 349
– Number of Females: 44
• Reporting clinics – 86%
– At least one report from 31 clinics
– None from 5 clinics
Descriptive analysis of data:Broad overview of notified cases
Year
Total reports
2002 0
5
10
15
20
2001
Nu
mb
er
of
cas
esLondon enhanced surveillance:Total number of cases reported by year
Heterosexual Homosexual or bisexual
0
5
10
15
2002 2001 Year
Nu
mb
er o
f ca
ses
London enhanced surveillance:Number of cases by month and orientation
Distribution of reported cases
Heterosexual femaleHeterosexual maleHomo/bisexual male
John Hunter, n = 62
King’s, n=21
Royal Free, n=27
Mortimer Market, n=49
St Thomas’, n=22
Royal London, n= 28
Victoria clinic, n=19
Homerton, n=17
Archway, n = 16
St Mary’s, n=22
14%
74%
1% 11%
Heterosexual Males(n=56)
Homosexual Males (n=288)
Bisexual Males (n=4)
Female (n=44)
Total number of reports = 393
London enhanced surveillance:Reports by gender and sexual orientation
London enhanced surveillance:Reason for clinic attendance by sexual orientation
p<0.001
0
20
40
60
80
100
Routinescreen
Symptoms Contacttracing
Other
Perc
en
tag
e
Heterosexuals (n=80)
Homo/Bisexuals (n=292)
London enhanced surveillance:Age distribution by sexual orientation
0
10
20
30
40
50
<19 20-24 25-34 35-44 45+
Perc
en
tag
e
Heterosexuals (n=100)
Homo/Bisexuals (n=292) p<0.001
0
20
40
60
80
100
UK Rest of Europe Other
Perc
en
tag
e
Heterosexuals (n=94)
Homo/Bisexuals (n=279)
London enhanced surveillance:Country of birth by sexual orientation
p<0.001
London enhanced surveillance:Ethnicity by sexual orientation
0
20
40
60
80
100
White Black C Black _O Other
Perc
en
tag
e
Heterosexuals (n=98)
Homo/Bisexuals (n=283) p<0.001
London enhanced surveillance:HIV status by sexual orientation
0
20
40
60
80
100
HIV Positive HIV Negative
Perc
en
tag
e
Heterosexuals (n=60)
Homo/Bisexuals (n=242)p<0.001
London enhanced surveillance:Reported sexual partnerships in the last three months by sexual orientation
0
20
40
60
80
100
0 1 2 3 4 5 to 9 10 ormore
Perc
en
tag
e
Heterosexuals (n=89)
Homo/Bisexuals (n=269p<0.001
London enhanced surveillance:Site of likely acquisition of infection
43
0
0
4
53
85
3
2
4
17
London
Brighton
Manchester
Other UK
Outside UK
Homo/ bisexual men (n=302)Heterosexuals (n=95)
p<0.001
p<0.001
0
20
40
60
80
100
Primary Secondary Early Latent
Perc
en
tag
e
Heterosexuals (n=89)
Homo/Bisexuals (n=277) P=0.078
London enhanced surveillance:Stage of infection by sexual orientation
0
20
40
60
80
100
Yes No
Perc
en
tag
e
Heterosexuals (n=84)
Homo/Bisexuals (n=224)
London enhanced surveillance:Oral sex transmission by sexual orientation
p<0.001
London enhanced surveillance:Relevant social venues/ networks by sexual orientation
6
2
2
0
0
1
19
7
6
3
CSW contact
Bar
Sauna
Internet
Cruisingground
Homo/ bisexual men Heterosexuals
The interaction between syphilis and HIV
Syphilis in HIV positive men
• 128 HIV positive homo/bisexual men
– Median age 37 years cf. 31 years (HIV neg.)
– No significant differences with respect to:CoB, ethnicity, reasons for attending, oral sex transmission, reported partners,
– However significant differences wrt. stage of infection, where possibly infected
London enhanced surveillance:Stage of Infection by HIV Status
0
20
40
60
80
100
Primary Secondary Early Latent
Perc
en
tag
e
HIV positive (n=124)
HIV Negative (n=103)
Relevant social/ sexual networks
0
17
4
5
0
2
24
9
8
6
CSW contact
Bar
Sauna
Internet
Cruisingground
HIV Positive
HIV Negative
Summary of key findings
• Changing epidemiology
– Global increases in syphilis in London
– Broadly in keeping with recent national increases
• Infections in heterosexuals ongoing
– Predominantly from those born outside the UK, ethnic minorities
– Less likely to be HIV positive,
– Oral sex not a predominant feature
– Over half of infections assumed to be acquired abroad
Summary II
• Infections in homosexual men
– Ongoing
– Cluster likely to have been identified through increased ascertainment
– White, older (mean 36 years), HIV positive, sex on premises bars important focus
– Links with other epi-centres present but not significant
New arrangements for enhanced laboratory
surveillance of infectious syphilis in
England and Wales
Current arrangements for laboratory surveillance• Enhanced laboratory
surveillance currently undertaken via the five PHLS syphilis reference laboratories
• However system is limited by its poor timeliness and lack of coverage.
• Approximately 40% of all diagnoses in country referred and confirmed at these sites
GUM: Patient diagnosed with syphilis
CDSC: Merged syphilis database
LAB: Sample confirmed at local laboratory
REFERENCE LAB: For confirmatory testing
New syphilis reporting scheme: Objectives
• The new surveillance system is being established to:
– monitor levels and trends of syphilis infection
– provide data on risk behaviours and transmission networks
– identify groups to target for testing and screening initiatives;
– determine the national and regional impact of syphilis infections.
Health professional reports case directly
Receipt of laboratory report initiates clinical reporting
GUM: Patient diagnosed with syphilis
CDSC: Merged syphilis database
LAB: Sample confirmed at local laboratory
New syphilis reporting scheme: Brief system description
• All laboratories in England and Wales to report new cases to CDSC.
• CDSC to obtain enhanced data from GUM clinics.
• CDSC will also collected data from existing enhanced surveillance.
New syphilis reporting scheme: Phase 1: Rapid laboratory reporting
• All laboratories to report to CDSC, all confirmed cases of infectious syphilis.
– A laboratory reporting form or
– electronic reporting via CoSurv to collect information.
• Direct lab reporting should decrease delay and allow better real-time monitoring.
GUM: Patient diagnosed with syphilis
CDSC: Merged syphilis database
LAB: Sample confirmed at local laboratory
Fig. 1 Rapid, direct laboratory reporting
New syphilis reporting scheme: Phase 2: Enhanced patient data collection
•CDSC will collate and verify laboratory data and arrange for the collection of enhanced clinical data from GUM clinics.
•This will involve direct contact with the GUM physician or health adviser.
•The CDSC coordinator will enter data into a password protected satellite database, linked to the lab report.
GUM: Health professional reports case directly
Receipt of laboratory report initiates clinical reporting
CDSC: Merged syphilis database
Fig. 2 Passive enhanced surveillance
New syphilis reporting scheme: Phase 3: Active clinical reporting
•Used in high incidence areas, or in sites with outbreaks.
•Methodology similar to the London enhanced system:
– GUM clinics to nominate a local syphilis coordinator.
– Triplicate copies of the clinical data collection form to be held locally.
– For each patient seen local syphilis coordinator to return form to the CDSC
GUM: Patient diagnosed with syphilis
Health professional reports case
GUM: Patient diagnosed with syphilis
CDSC: Merged syphilis database
LAB: Sample confirmed at local laboratory
Fig. 3 Active enhanced surveillance
New syphilis reporting scheme: Timetable for implementation
• System to go ‘live’ on 1st July 2002.
• Pilots already established in Eastern Region and West Midlands
• Enhanced surveillance in London to be continued for the foreseeable future.
• Roll-out to other regions by end-August 2002.
Summary and conclusions
• Recent increases in syphilis raise cause for concern
• Enhanced surveillance has played a key role in syphilis prevention and control
• Need for improved surveillance to co-ordinate national response
• The London enhanced surveillance programme has confirmed the feasibility and acceptability for such programmes
Acknowledgements
• We gratefully acknowledge the continuing collaboration of health advisors, clinicians, clinic staff, microbiologists and everyone else who contributes to STI and HIV surveillance in the UK
• PHLS CDSC prepares the data in collaboration with:
– Scottish Centre for Infection and Environmental Health, Information and Statistics Division Scotland, Department of Health Social Services & Public Safety in Northern Ireland, Institute of Child Health, Oxford Haemophilia Centre.