Infection: Species Malassezia Part -1

Introduction

• Species Malassezia is part of the normal flora, particularly present in sebumrich areas of the skin.

• Mycelial form is capable of causing clinical disease.

Species of Malassezia

• M. furfur, • M. pachydermatis,• M. sympodialis,• M. globosa, • M. restricta, • M. slooffiae, • M. obtusa,• M. dermatis, and• M. equi.

• M. japonica,• M. nana, and • M. yamatoensis

Epidemiology

• Seen all over the world.• Common in warm, humid environment.

Microscopically: Malassezia sp.

• Have long and short septate.

• Occasionally branching hyphae with a “spaghetti and meatballs” appearance

Number of Pityrosporum in skin

• Malassezia furfur is abundant in normal skin (504,000 organisms/cm2 vs. 922,000 in individuals with dandruff and 665,000 in patients with seborrheic dermatitis).

Contageousness

• Malassezia infections are not contagious

• An opportunistic infection of the skin.

Pathogenesis

• Ability of Malassezia to produce phospholipase, which directly correlates with skin infection.

Role of Malassezia

Causes a wide spectrum of superficial cutaneous disease:-

• Tinea (pityriasis) versicolor,

• Pityrosporum folliculitis, • ? Seborrheic dermatitis,

Contributing to • Atopic dermatitis • Psoriasis.

Habitus

• Lipophilic organism• Growth in vitro - C12 to C14 fatty acids such as olive oil

and lanolin• M. pachydermatis does not require exogenous lipids.• Concentrated on sebumrich areas of the skin.• Colonization in follicular structures

Infection: Species Malassezia Part -2Coming soon

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