Indiana Institute For Personalized Medicine

David A Flockhart MD, PhDDavid A Flockhart MD, PhD

Professor of Medicine, Genetics and Pharmacology Professor of Medicine, Genetics and Pharmacology

Indiana University Indiana University

Challenges for Personalized Medicineas a Health Care Solution

Genomics has not deliveredGenomics has not delivered Proteomics has not deliveredProteomics has not delivered Bioinformatics has not deliveredBioinformatics has not delivered Small and Dry Pharmaceutical PipelinesSmall and Dry Pharmaceutical Pipelines Effective Electronic Medical Records are Rare Effective Electronic Medical Records are Rare

EventsEvents

•.

F S Collins Science 2011;331:546-546

It’s Been Ten Years

•“the once-hypothetical medical benefits of individual genome sequencing are

beginning to be realized in the clinic.”

•F S Collins Science 2011;331:546-546

•….in fact, it's one of the many reasons that NIH plans to create a National Center

for Advancing Translational and Therapeutic Sciences

““If I could move the clock back to 2001 and change If I could move the clock back to 2001 and change course, I would invest significantly more in course, I would invest significantly more in developing large clinical resources with detailed, developing large clinical resources with detailed, individual clinical histories, deep phenotyping, individual clinical histories, deep phenotyping, and longitudinal follow-up in order to better and longitudinal follow-up in order to better understand outcomes and treatment responses”understand outcomes and treatment responses”

•Tom Hudson, Science 2011;331:547

The Genome Wide Association barrier : 282 Genome Wide Association StudiesPublished in Peer-Reviewed Journals since January 2007

Genome Wide Association as a tool for predictive medicine

•Fletcher R, Flockhart DA, 2010

Genome-wide association study identifies 6 novel breast cancer susceptibility loci

Nature May 27th, 2007

•1.27 fold = the risk conferred by 1 glass of wine per day

Tools for Personalized Medicine in Indiana A Robust Electronic Medical Record with Long Follow UpA Robust Electronic Medical Record with Long Follow Up A Biobank of Samples that Links to the EMRA Biobank of Samples that Links to the EMR Genomic and Pharmacogenomics ExpertiseGenomic and Pharmacogenomics Expertise Imaging ExpertiseImaging Expertise Informatic ExpertiseInformatic Expertise

Center for Computational BiologyCenter for Computational Biology

Modeling ExpertiseModeling Expertise CTSI Disease and Therapeutics Modeling ProgramCTSI Disease and Therapeutics Modeling Program

Trained ProfessionalsTrained Professionals Strategic Partnerships with ImplementersStrategic Partnerships with Implementers

Implementers of Personalized Medicine

PatientsPatients PhysiciansPhysicians PharmacistsPharmacists NursesNurses Diagnostic CompaniesDiagnostic Companies Pharma CompaniesPharma Companies BiotechBiotech

Indiana Institute For Personalized Medicine

Founded January 1Founded January 1stst, 2011, 2011

Schools of Medicine, Nursing and Informatics, IU Schools of Medicine, Nursing and Informatics, IU Cancer Center and the Regenstrief InstituteCancer Center and the Regenstrief Institute

Open to all IU FacultyOpen to all IU Faculty New Brater Fellowships in Personalized MedicineNew Brater Fellowships in Personalized Medicine New Pilot fundingNew Pilot funding New FacultyNew Faculty

Brater Scholar Program

A Mentored Program to Prepare Physician A Mentored Program to Prepare Physician Scientists for Careers in Personalized MedicineScientists for Careers in Personalized Medicine

Emphasis on Peer Collaboration Among FellowsEmphasis on Peer Collaboration Among Fellows Salary supplementSalary supplement $ for supplies and travel$ for supplies and travel

2011 Brater Scholars in Personalized Medicine Troy Quigg MD, Pediatric OncologyTroy Quigg MD, Pediatric Oncology Vic Senadhi MD, Division of GastroenterologyVic Senadhi MD, Division of Gastroenterology Jody Skiles, Department of PediatricsJody Skiles, Department of Pediatrics

Indiana Biobank: Goals To create a statewide, robust collection of biological samples

To be accessible to basic and clinical investigators as a research tool

• To enroll and collect samples from 50,000 patients in 5 years

Established in July 2010

50,000 high quality samples in 5 yearslinked to the electronic medical record

and to genomic and proteomic data.

•Available to basic and clinical researchers.

•Patients from Clarian Health, Wishard and other clinical venues throughout Indiana: a Key Research Arm of the IU Health system

Indiana Biobank: Purpose

Anne Nguyen CCRP

Academic Strategic Partnerships

Department of MedicineDepartment of Medicine Department of PediatricsDepartment of Pediatrics

PREGMEDPREGMED Center for Pediatric Clinical TherapeuticsCenter for Pediatric Clinical Therapeutics

Department of OB/GYNDepartment of OB/GYN IU Cancer CenterIU Cancer Center

Center for Computational BiologyCenter for Computational Biology Department of RadiologyDepartment of Radiology

Regenstrief InstituteRegenstrief Institute

Targeted Areas for Strategic Partnerships

Diagnostics OrganizationsDiagnostics Organizations Therapeutics OrganizationsTherapeutics Organizations

International:International: KenyaKenya ChinaChina

NIHNIH FDAFDA

Indiana Institue For Personalized Medicine Leadership

Lang Li PhDComputational

BiologyBryan Schneider MD

IU Cancer CenterJamie Renbarger MD, MS

Pediatrics

Anne Nguyen CCRPIndiana Biobank