1405

IN APPRECIATION

This month the Editor in Chief and Assistant Editor end their terms with The Journal ofPharmacology & Experimental Therapeutics. We wish to express our sincere appreciation toall the Editors for Specific Fields and members of the Editorial Advisory Board who havecontributed so much of their time and expertise to maintaining the excellence of The Journalas a place in which our colleagues from all over the world can share their findings. Further wewish to acknowledge with gratitude the colleagues who contributed special expertise as GuestEditors for Specific Fields in 1991.

Martin W. AdlerEdson X. AlbuquerqueThomas F. BurksPeter CervoniMarlene L. CohenRichard A. CohenCharles R. CraigHarold FemnbergRay W. FullerGary L. HendersonRobert M. JoyBenedict R. Lucchesi

Michael I. LusterJohn McGiffArthur RainesLewis S. SeidenTheodore A. SlotkinLarry SteinRobert I. TaberA.E. TakemoriR. Clinton WebbThomas C. WestfallGrant R. WilkinsonPaul H. Wooley

Additionally, sincere thanks are due to our colleagues not on the Editorial Advisory Board whoreviewed articles for The Journal in 1 991 . Their contributions are acknowledged individually inthe Annual Report of The Journal to The Board of Publications Trustees and The AmericanSociety for Pharmacology and Experimental Therapeutics.

It has been an honor and a privilege to edit The Journal of Pharmacology & ExperimentalTherapeutics.

Eva King Killam, Ph.D., EditorMannfred A. Hollinger, Ph.D., Assistant Editor

INDEX

Volume 259, October-December, 1991

A23187, release ofplatelet-activating factor,prostaglandin production, kidney

(rats), 590Abad, F., see Lopez, M. G., 279

Abraham, S. T., see Rice, P. J., 1182Abrahams, T. P., Hornby, P. J., Walton, D.

P., DaSilva, A. M. T. and Gillis, R.

A. Excitatory amino acid(s) in theventrolateral medulla is (are) re-

quired for breathing to occur in theanesthetized cat, 1388

Acetate, central nervous system effects(rats, mice), 403

Aceto, E. and Vassalle, M. On the mecha-nism of the positive inotropy of lowconcentrations of strophanthidin,182

Acetylcholinedifferential inhibition of neuropeptide Y,

chronotropic and inotropic re-sponses, atrium (dogs), 38

effects of guanidino compounds, NG�mon�omethyl L-arginine (rats), 490

-induced contraction in trachea, chemicaloxidant, cholinesterase inhibition

(rats), 371

N#{176}-monomethyl-L-arginine-inducedpressor response, developmental and

established stages, spontaneously hy-

pertensive rats, 52striatal release, dopaminergic regulation,

Dl and NMDA receptors (rats), 1064

N-Acetyl-L--y-glutamyl, renal selective pro-

drugs (rats), 766

N-Acetylprocainamide, rate-dependent ef-fects of lidocaine, His-Purkinje con-duction, neonatal heart (dogs), 535

N-Acetyltransferase, isozymes in tumor tar-

get organ cytosols, polymorphic andmonomorphic expression (hamsters),

699a-i Acid glycoprotein, oxidation products of

norepinephrine, binding, plasma pro-thins, 551

Action potential, electrophysiology, sodium

channel blockers, left atrium (guineapigs), 884

Adderholt, J. G., see Farley, J. M., 241Adenosine

A2 agonists, cardiovascular effects, li-gands (rats), 1203

A1- and A2-selective agonists and antago-nists, behavioral effects (mice), 286

adenosine 3 ‘ ,5’ -cyclic monophosphateand, intracerebroventricular mor-phine release, spinal cord (rats), 1013

Adenosine triphosphate

-evoked ATP release system, smoothmuscles (guinea pigs), 513

reduction of infarct size by aprikalim, ab-sence of hemodynamic changes

(dogs), 961

Adenylate cyclase

flerobuterol interactions, beta adrenocep-tors, brain (rats), 414

1406

inhibition, attenuation, adenosine recep-tsr-mediated relaxation in coronary

artery (pigs), 508modulation of responsiveness, meth-

ylxanthine treatment, smooth musclecells, 925

monoaminergic receptors, hypothalamic

nuclei, feeding behavior (rats), 124muscarinic stimulation, olfactory bulb

(rats), 673, 680Adipose tissue, beta adrenoceptors, cat-

echolamine tachyphylaxia (humans),317

Adrenal gland, catecholamine release, mem-brane-mediated effects, steroid 17-a-

estradiol (cats), 279Adrenoceptors

a’phaantagonism of norepinephrine by don-

idine, mesenteric vascular bed (rats),653

imidazoline desensitization, epineph-

rine responses in vas deferens (rats),1182

water diuretic effects, AGN 190851

(rats, dogs, monkeys), 1277alpha.1

activation by dexmedetomidine (rats),1147

cardiac outward current reduction(rats), 783

renal medullary collecting duct cells

(rabbits), 1081a�pha-2

behavioral and neurochemical effects,

medetomidine (rats), 848functional subclassification, SK&F

104856 (dogs, rabbits, humans,guinea pigs), 643

subtype identification, SK&F 104078and SK&F 104856 (guinea pigs), 1124

a4,ha-2C, opossum kidney, OK cell line,323

betadesensitization to bronchodilators,

platelet-activating factor (guineapigs), 1

flerobuterol interactions, brain (rats),414

beta-2, intracoronary procaterol, myocar-

dial ischemia (dogs), 732beta-i and beta-2

catecholamine tachyphylaxia, adipose

tissue (humans), 317smooth muscle relaxation, bovine mes-

enteric lymphatics, 365Adrenocorticotropin hormone, cocaine-in-

duced elevation, corticosterone, se-rotonergic neurons (rats), 495

AF-DX 384, binding to cloned and nativemuscarinic receptors (rats), 601

Aging, changes in vascular sympathetic neu-

rotransmission, kidney (rats), 176AGN 190851, water diuretic effect, alpha

adrenoceptor agonist (rats, dogs,monkeys), 1277

Agrawal, D. K., Bergren, D. R., Byorth, P.J. and Townley, R. G. Platelet-acti-vating factor induces nonspecific de-sensitization to bronchodilators inguinea pigs, 1

Aharony, D., Catanese, C. A. and Wood-house, D. P. Binding of the novelligand [4,5-3H-Leut0]substance P tohigh-affinity NK-i receptors onguinea pig lung membranes: Modu-lation by GTP analogs and sulfhydrylmodifying agents, 146

Ahmed, N. K., see Linnik, M. D., 501Aikawa, T., see Ohrui, T., 371

Albumin, oxidation products of norepineph-rine, binding, plasma proteins, 551

Albuquerque, E. X., see Swanson, K. L., 377

Albuquerque, E. X., see Wonnacott, S., 387Alcohols, modulation of GABA receptor-

channel complex (rats), 235Alpert, N. M., see Fischman, A. J., 1351Amar, C., see Pons, C., 1328Amino acid

excitatory

receptor agonist, contralateral turning(rats), 1366

ventrolateral medulla, requirements forbreathing (cats), 1388

p-Aminobenzoic acid, monomorphic ary-

lamine N-acetyltransferase expres-sion, human leukocytes, 1241

‘y-Aminobutyric acid

-mediated inhibition, potentiation byethanol, inferior colliculus (rats),1288

morphine-tolerant longitudinal muscle,myenteric plexus preparation (guineapigs), 1094

sensitivity of cerebellar Purkinje neurons,neurotransmitters, genetically epi-

leptic rats, 10085-Aminocarbonyl-10,ii-dihydro-5H-&-

benz[a,djcyclohepten-5,10- imine,anticonvulsant activity (mice, rats),30

p-Aminohippurate, reduction in transportand passive membrane permeability,dehydroabietic acid, renal mem-

branes (rats), 156D,L-a-Amino-3-hydroxy-5-methyl-4-isoxa-

zole propionate, receptors on synap-tosomes from striatum, presynaptic

facilitation, dopamine release (rats),

692Aminopeptidase, metabolism and poor

membrane permeation, intestinal ab-sorption, leucine enkephalin (rats),

139

Aminopeptidase P, pulmonary endothelial,

species variation (cattle, humans,rats, rabbits, cats, minipigs), 1301

Amitriptyline, imipramine as a discrimina-

tive stimulus (pigeons), 1088

1991 Index 1407

Amphetamine, sensitization to psychostim-

ulants and stress, pertussis toxin in-

jection, AlO dopamine region (rats),916

Amyl nitrite, vascular nitric oxide-generat-

ing activities, organic nitrites, or-

ganic nitrates, 519

Analgesia

antinociceptive action, opiates and opioidpeptides, area tempestas (rats), 1308

distribution of [3H][D-Pen2,D-Pen5]en-

kephalin (mice), 1109increased potency of mu agonists, contin-

uous naloxone infusion (rats), 582

lack of spinal antianalgesic activity, dy-norphins (mice), 1073

opioid receptor activity, GI 870MB

(guinea pigs, rats, mice), 712Anatoxin analogs, nicotinic pharmacology,

377, 387

Anesthesia, opioid receptor activity, GI870MB (guinea pigs, rats, mice), 712

Anesthetics, electrophysiological actions of

BRB-I-28, myocardial tissues (dogs),558

Angiotensin, chronic insulin treatment,

sympathetic activation (rats), 131

Angiotensin-converting enzyme, inhibitor,

inhibition of thromboxane synthe-

tase, antihypertensive action (rats),

219

Angiotensin IIpharmacology of DuP 532 (rats), 861

receptor antagonists PD123177 and DUP

753, inhibitory potency, proximal

nephron and renal transport (rats),687

release of platelet-activating factor, pros-taglandin production, kidney (rats),

590

Antiandrogen, pharmacokinetics and me-tabolism, nilutamide (rats), 1247

Antiarrhythmic drugs

arrhythmogenic activities, atrioventricu-

lar block (dogs), 871

electrophysiological actions of BRB-I-28,

myocardial tissues (dogs), 558rate-dependent effects of lidocaine, His-

Purkinje conduction, neonatal heart(dogs), 535

Anticoagulants, properties of synthetic po-lyanions (humans), 8

Anticonvulsants, 5-aminocarbonyl-10,11-

dihydro-5H-dibenz[a,d]cyclohepten-

5,10 -imine, comparison with dizocil-

pine and carbamazepine (mice, rats),30

Antidepressants, imipramine as a discrimi-

native stimulus (pigeons), 1088Antihypertensive agents, induction of pos-

tural hypotension, central and pe-

ripheral components (rats), 1221

Anti-inflammatory activity, pergolide

(rats), 169

Anti-ischemic agents, TA3090, block of neu-ronal Ca�� influx (rats), 430

Antinociceptionaction of opiates and opioid peptides, uni-

lateral microinjection, area tempes-tas (rats), 1308

distribution and analgesia, [3H][D-Pen2,

D-Pen5]enkephalin (mice), 1109inhibition of tail-flick response, epsilon

and kappa opioid receptors, brema-

zocine (mice), 330

lack of spinal antianalgesic activity, dy-

norphins (mice), 1073

selective antagonism by naltrindole,

cyclic[D-penicillamine2-D-

penicillamine5j enkephalin (rats),725

Antiplatelet agents, plasminogen activatorsand, rapid dissociation, platelet-rich

fibrin clots (humans), 1371

Antiulcer activity, pharmacological profile

ofUP 5145-52 (rats), 190Anxiolytics, behavioral effects of U-78875

(rats), 248

Aortadesensitized, reduced G protein function

(rats), 255

responses to nitric oxide and superoxide,

ultraviolet irradiation of solutions

(rabbits), 1140

Apamin, potassium channel blockers and

cromakalim, mechanical activity, de-trusor smooth muscle (guinea pigs),

1158

Aposhian, H. V., see Maiorino, R. M., 808Aprikalim

reduction of experimental infarct size, ab-

sence of hemodynamic changes

(dogs), 961

vasorelaxation, nicorandil, potassium

channel opening (rats), 526

Arachidonic acid, bradykinin and, neuro-peptide release, capsaicin-sensitive

sensorynerve fibers of heart (guinea

pigs), 759

Arakawa, 0., see Nakahiro, M., 235

Area tempestas, antinociceptive action, opi-ates and opioid peptides (rats), 1308

Argov, Z., Nioka, S., Eleff, S. and Chance,B. Effects of intra-arterial epineph-rine on energy metabolism in exercis-ing rabbit gastrocnemius muscle,

studied by in vivo phosphorus nuclear

magnetic resonance, 458

Armario, A., see Hidalgo, J., 274Arner, P., Kriegholm, E. and Engfeldt, P.

In vivo interactions between Beta-i

and Beta-2 adrenoceptors regulate

catecholamine tachyphylaxia in hu-

man adipose tissue, 317

Aronstam, R. S., see Swanson, K. L., 377

Arrhythmia

stereoselective disposition and metabo-

lism, disopyramide, pediatric pa-

tients, 953

ventricular, intravenous magnesium,

acute myocardial infarction (dogs),939

Artaud, F., see Desce, J. M., 692Artery

contractile responses, sigma receptor li-

gands (rats), 22

coronaryinhibition of adenylate cyclase, adeno-

sine receptor-mediated relaxation

(pigs), 508

nicorandil, vasorelaxation (rats), 526serotonin-induced endothelium-de-

pendent relaxation (bovine), 1316staurosporine, specific inhibitor of pro-

tein kinase C (pig), 10i9

vascular nitric oxide-generating activi-ties, 519

femoral and coronary, vascular actions,

TA 3090 (dogs), 639

superior mesenteric, glucagon pharmaco-

dynamics (cats), 118Arylamine, carcinogen N-acetyltransferase

isozymes, tumor target organ cytosols(hamsters), 699

Arylamine N-acetyltransferase, mono-

morphic, human leukocytes, 1241

Asayama, J., see Shirayama, T., 884Ascorbate, inhibition of binding to PN200-

110 to membranes, lipid peroxidation

(rats), 337Ashford, M. L. J., see Zini, S., 566Ashton, P., Wang, W. and Lee, V. H. L.

Location of penetration and meta-

bollic barriers to levobunolol in the

corneal epithelium of the pigmentedrabbit, 719

Aspirin

inhibition by salicylic acid, oxidation,long chain fatty acids (mice), 894

presystemic acetylation of platelets (hu-mans), 1043

Asthma, nonspecific desensitization to

bronchodilators, platelet-activating

factor (guinea pigs), 1Atrium

differential inhibition of neuropeptide Y,chronotropic and inotropic responses(dogs), 38

functional subclassification, alpha-2 ache-

noceptors (dogs, rabbits, humans,

guinea pigs), 643left, electrophysiology, sodium channel

blockers (guinea pigs), 884Auchampach, J. A., Maruyama, M., Cavero,

I. and Gross, G. J. The new K� chan-nel opener aprikalim (RP 52891) re-duces experimental infarct size indogs in the absence of hemodynamic

changes, 961Aungst, B. J., Blake, J. A. and Hussain, M.

A. An in vitro evaluation of metabo-lism and poor membrane permeation

impeding intestinal absorption ofleucine enkephalin, and methods toincrease absorption, 139

Autoantibodies, human hepatitis anti-liver

kidney microsomes, liver sections(rats), 1328

Autonomic nervous system, differential in-hibition of neuropeptide Y, chrono-tropic and inotropic responses,atrium (dogs), 38

Autoradiography, pharmacological charac-

terization, serotonin-O-carboxyme-

thyl-glyceryl-tyrosinamide (rats,

guinea pigs), 1360Azidothymidine, nonprimate animal model,

zidovudine pharmacokinetics in hu-mans, 1261

Baclofen, cerebrocortex nerve terminals,

GABAB receptors, inhibition of so-matostatin release (rats), 1153

Baines, A. D., see Cardoso, P. F. G., 1271Baker, J. C., see Blaxall, H. S., 323Bakkum, E. A., see Rittenhouse, P. A., 58Balboa, A., see Mays, D. C., 1261Banks, W. A., Ortiz, L., Plotkin, S. R. and

Kastin, A. J. Human interleukin (IL)la, murine IL-la and murine IL-lfi

are transported from blood to brainin the mouse by a shared saturable

mechanism, 988

Barclay, B. W., see Webb, R. L., 1203Barden, A., see Nies, A. S., 590

1408 Index

Barg, J., see Belcheva, M. M., 302Baron, B. M., see Reynolds, I. J., 626

Barrett, J. E., see Zhang, L., 1088

Bascom, H., Kagey-Sobotka, A. and Proud,D. Effect of intranasal capsaicin onsymptoms and mediator release, 1323

Battaglia, G., see Levy, A. D., 495

Bauer, M. R., see Mays, D. C., 1261

Bauer, R. F., see Perkins, W. E., 1004

Bay K 8644, new site for activation, cardiaccalcium channels, FPL 64176 (rats),

982

B#{233}dard, P. J., see Gomez-Mancilla, B., 409Behavior

A1- and A2-selective adenosine agonistsand antagonists (mice), 286

effects of U-78875 (rats), 248

FCE 23884, substrate-dependent interac-tion, dopaminergic system (mice,

rats, dogs, marmosets, monkeys),

345, 356feeding, monoaminergic receptors, hypo-

thalamic nuclei (rats), 124metabotropic excitatory amino acid re-

ceptor agonist, intrastriatal injection,contralateral turning (rats), 1366

reinforcing and subjective effects of mor-phine, post-addicts, 1165

B#{233}langer,P. M., see Turgeon, J., 789

Belcheva, M. M., Barg, J., McHale, R. J.,Gao, X.-M., Chuang, D.-M. and Cos-cia, C. J. Up-regulation of Deltaopioid receptors in neuroblastoma

hybrid cells: Evidence for differences

in the mechanisms of action of so-

dium butyrate and naltrexone, 302Ben-An, Y., see Zini, S., 566

Bendele, A. M., Spaethe, S. M., Benslay, D.N. and Bryant, H. U. Anti-inflam-

matory activity of pergolide, a dopa-

mine receptor agonist, 169

Benishin, C. G., see Sun, Y.-D., 947

Bennett, L. E., see Leedham, J. A., 295Bennett, L. E., see Taylor, D. A., 1084Benslay, D. N., see Bendele, A. M., 169

Benuck, M., see Reith, M. E. A., 1188Benzamide, -induced gastroprokinesis, se-

rotonergic mechanisms (rats), 501Benzodiazepines

behavioral effects of U-78875 (rats), 248

peripheral-type, inhibitory action on do-

pamine release, PC12 pheochromo-cytoma cells, 484

Benzothiazepines, vascular actions of TA3090 (dogs), 639

Bergren, D. R., see Agrawal, D. K., 1

Berlin, K. D., see Patterson, E., 558

Bernat, A., see Herbert, J. M., 44Berson, A., see Deschamps, D., 894Beta blockers, inhibition of thromboxane

synthetase, antihypertensive action,

angiotensin-converting enzyme

(rats), 219

Bezold-Jarisch reflex, serotonin receptorblocking activities, YMO6O (rats), 815

Bile, renal selective N-acetyl-L-’y-glutamylprodrugs (rats), 766

Bilotta, J. M., see James, M. K., 712Bis-aldonic acid amides, antithrombotic and

anticoagulant properties, syntheticpolyanions (humans), 8

l,10-Bis(guanidino)decane, inhibition of N-methyl-D-aspartate responses (rats),

626

Blackburn, T. P., see Hieble, J. P., 643

Bladderarylamine carcinogen N-acetyltransferase

isozymes, tumor target organ cytosols

(hamsters), 699detrusor smooth muscle, mechanical ac-

tivity, potassium channel blockersand cromakalim (guinea pigs), 1158

Blake, J. A., see Aungst, B. J., 139Blaxall, H. S., Murphy, T. J., Baker, J. C.,

Ray, C. and Bylund, D. B. Character-ization of the Alpha-2C adrenergic

receptor subtype in the opossum kid-ney and in the OK cell line, 323

Bleakman, D., Chard, P. 5., Foucart, S. andMiller, R. J. Block of neuronal Ca�influx by the anti-ischemic agentTA3090, 430

Blood-brain barrierdistribution and analgesia, [3H][D-Pen2,

D-Pen5]enkephalin (mice), 1109facilitated transport ofcefodizime, central

nervous system (rats), 620

selective transport of anti-transferrin re-

ceptor antibody (mice, rats, humans,cattle), 66

transport, human interleukin la, murineinterleukin la and lfl, 988

Blood pressurecardiovascular effects of adenosine A2 ag-

onists, ligands (rats), 1203

chronic insulin treatment, sympatheticactivation (rats), 131

increased renin secretion and, DO!, 5-

HT2 receptors (rats), 58

pharmacology of DuP 532 (rats), 861

renal effects and elimination, sulotroban(dogs), 1231

BMY 14802, sigma ligands, contractile re-

sponses (rats), 22

Bonanno, G., Gemignani, A., Fedele, E.,Fontana, G. and Raiteri, M. r-Ami-nobutyric acidB receptors mediate in-hibition of somatostatin release fromcerebrocortex nerve terminals, 1153

Boomsma, F., Man In’T Veld, A. J. andSchalekamp, M. A. D. H. Not nor-epinephrine but its oxidation prod-

ucts bind specifically to plasma pro-teins, 551

Borg, C., Mondot, S., Mestre, M. and Cay-ero, I. Nicorandil: Differential con-tribution of K� channel opeining andguanylate cyclase stimulation to itsvasorelaxant effects on various en-dothelin-1-contracted arterial prepa-

rations. Comparison to aprikalim(RP 52891) and nitroglycerin, 526

Borgeat, P., see De Brum-Fernandes, A. J.,1035

Borges, R., see Lopez, M. G., 279Boulenguez, P., Chauveau, J., Segu, L., Mo-

rel, A., Delaage, M. and Lanoir, J.

Pharmacological characterization of

serotonin-O-carboxymethyl-glycyl-tyrosinamide, a new selective indolicligand for 5-hydroxytryptamine (5-HT)1B and 5-HT1D binding sites, 1360

Brackeen, M. F., see James, M. K., 712Bradycardia

arrhythmogenic activities, antiar-

rhythmic drugs, atrioventricular

block (dogs), 871

-inducing agent, ionic currents, E4080(rabbits), 1396

Vol. 259

serotonin receptor blocking activities,YMO6O (rats), 815

Bradykinin

analogs and, lower esophageal sphincter(opossums), 265

arachidonic acid and, neuropeptide re-lease, capsaicin-sensitive sensorynerve fibers of heart (guinea pigs),759

hypotensive effects of lys-des-ar�-brady-kinin, metabolically protected ago-nists, B1 receptors for kinins (rab-bits), 997

mediation of pertussis toxin-insensitive

biphasic response, circular muscle,ileum (guinea pigs), 659

release of platelet-activating factor, pros-taglandin production, kidney (rats),590

Brainbinding of AF-DX 384, cloned and native

muscarinic receptors (rats), 601

cerebral cortical synaptosomes, tetra-phenylphosphonium accumulation,nicotine-induced changes in mem-

brane potential (rats), 1118

discrete regions, benzodiazepine recep-tors, cocaine (rats), 574

flerobuterol interactions, beta adrenocep-

tors (rats), 414

heterogeneity of NMDA receptor iono-phore complex (rats), 86

5-HT1�2 agonists, thoracic spinal cord(rats), 1335

inferior colliculus, GABA-mediated inhi-bition, potentiation by ethanol (rats),1288

inhibition of binding of PN200-i10 tomembranes, ascorbate, lipid peroxi-dation (rats), 337

membranes, specific binding sites, leuko-triene B4 (guinea pigs), 1035

pharmacological characterization, mm-

tonin-O-carboxymethyl-glyceryl-ty-rosinamide (rats, guinea pigs), 1360

Brater, D. C., see Rudy, A. C., 1133BRB-I-28, electrophysiological actions,

myocardial tissues (dogs), 558Breathing, requirements, excitatory amino

acids, ventrolateral medulla (cats),1388

Breese, G. R., see Simson, P. E., 1288

Bremazocine, inhibition of tail-flick re-sponse, epsilon and kappa opioid re-ceptors (mice), 330

Brodkin, J., see Nash, J. F., 820

Bronchoconstriction

C5a-induced, inhibition by H1 antagonist(guinea pigs), 1213

pharmacologic actions of Ro 24-5913 (hu-

mans, guinea pigs), 751pharmacology of Ro 24-4736 (guinea pigs,

dogs, humans), 78Bronchodilators, induction of nonspecific

desensitization, platelet-activatingfactor (guinea pigs), 1

Bronchus, capsaicin-sensitive and cholin-ergic nerves, functional interactions(guinea pigs), 104

Brooks, D. P., Edwards, R. M., Depalma, P.D., Fredrickson, T. A., Hieble, J. P.and Gellai, M. The water diureticeffect of the Alpha adrenoceptor ag-onist, AGN 190851, is species-de-pendent, 1277

1991 Index 1409

Broomfield, C. A., Maxwell, D. M., Solana,R. P., Castro, C. A., Finger, A. V. and

Lenz, D. E. Protection by butyryl-cholinesterase against organophos-

phorus poisoning in nonhuman pri-

mates, 633

Brush border membrane, mechanism ofvancomycin transport in kidney (rab-bits), 1283

Bryant, H. U., see Bendele, A. M., 169

Bucher, K. D., see Hem, D. W., 699Buciak, J. L., see Pardridge, W. M., 66

Bu#{241}ag,R. D., Krizsan-Agbas, D. and Itoh,H. Sympathetic activation by chronicinsulin treatment in conscious rats,

131

Buonamici, M., Mantegani, S., Cervini, M.

A., Maj, R., Rossi, A. C., Caccia, C.,Carfagna, N, Carminati, P. and Far-iello, R. G. FCE 23884, Substrate-

dependent interaction with the do-paminergic system. I. Preclinical be-havioral studies, 345

Buonamici, M., see Carfagna, N., 356

Burghardt, C., see Crowley, H. J., 78

Burks, T. F., see Weber, S. J., 1109Burton, E. G., see Perkins, W. E., 1004

Bush, L., see Hanson, G. R., 1197

Butler, B. T., see Linnik, M. D., 501

Butyrylcholinesterase, protection against

organophosphorus poisoning, non-

human primates, 633Bylund, D. B., see Blaxall, H. S., 323

Byorth, P. J., see Agrawal, D. K., 1

Cabrera, T. M., see Levy, A. D., 495

Caccia, C., see Buonamici, M., 345

Caccia, C., see Carfagna, N., 356

Caffeine, mechanism of positive inotropy,low concentrations, strophanthidin

(sheep), 182Calcitonin gene-related peptide, longitudi-

nal muscle and myenteric plexus,

ileum (guinea pigs), 947

Calciumcisapride action on muscarinic receptors,

contraction, gastric myocytes (guineapigs), 1294

currents and peptide release, neurohypo-physial terminals, inhibition byethanol (rats), 705

inhibition of NMDA responses, 1,10-

bis(guanidino)decane (rats), 626mechanism of positive inotropy, low con-

centrations, strophanthidin (sheep),

182

neuronal influx, block by TA3090 (rats),430

pertussis toxin-insensitive biphasic re-

sponse, bradykinin, circular muscleof ileum (guinea pigs), 659

specific inhibitor of protein kinase C,staurosporine, coronary arteries

(pig), 1019

stimulation of sodium transport, dura-mycin, colonic epithelia (humans),1050

Calcium channelactions of TA 3090, femoral and coronary

arteries (dogs), 639activation, nondihydropyridine FPL

64176 (rats), 982

bronchial smooth muscle membrane po-

tential, depolarizing agents (dogs),

110

desmethoxyverapamil binding, guanine

nucleotide-binding proteins, vascular

smooth muscle (rats), 164

hypoxic pulmonary vasoconstriction, van-adate (rats), 666

inhibition of binding to PN200-ll0 to

membranes, ascorbate, lipid peroxi-

dation (rats), 337

inhibition of thromboxane synthetase,

antihypertensive action, angiotensin-

converting enzyme (rats), 219

inhibitory action of peripheral-type ben-zodiazepines, dopamine release,

PC12 cells, 484Calcium channel blockers, intravenous

magnesium, ventricular arrhythmias,acute myocardial infarction (dogs),

939Calcium current, vasodilating actions of

E4080, smooth muscle cells, portal

vein (rabbits), 1396Calcium ionophore, release of platelet-acti-

vating factor, prostaglandin produc-

tion, kidney (rats), 590

Calixto, J. B. and Medeiros, Y. S. Charac-terization of bradykinin mediatingpertussis toxin-insensitive biphasic

response in circular muscle of the

isolated guinea pig ileum, 659

Campbell, S. M., see Marks, M. J., 392

Campisi, P., see Carmichael, F. J., 403Camus, P., Coudert, B., D’Athis, P.,

Foucher, P., Delchambre, J., Du-pront, A. and Jeannin, L. Pharma-cokinetics and metabolism of nilu-

tamide in the isolated rat lung, 1247

Candidiasis, pharmacokinetics of ‘8F-la-

beled fluconazole, positron emission

tomography (rats, rabbits), 1351

Cannon, J. G., see Park, K. H., 1221Capsaicin

intranasal, symptoms and mediator re-

lease (humans), 1323

-sensitive and cholinergic nerves, func-

tional interactions, bronchus (guinea

pigs), 104

-sensitive sensory nerve fibers of heart,

neuropeptide release, arachidonicacid and bradykinin (guinea pigs),

759

Carbamazepine, anticonvulsant activity, 5-aminocarbonyl-10,ll-dihydro-5H-di-

benz[a,d]cyclohepten -5,10-imine

(mice, rats), 30

Carcinogens, N-acetyltransferase isozymes,

tumor target organ cytosols (ham-

sters), 699

Cardiovascular system5-HT1�2 agonists, thoracic spinal cord

(rats), 1335

modification of function, central and pe-ripheral injections, 1-(2,5-dime-

thoxy-4-iodophenyl)-2-aminopro-

pane (rats), 1027

Cardoso, P. F. G., Spino, M., Mayer, E., Shi,S.-Q., Pop, R. D., Puskas, J., Perrier,D., Tong, J., Baines, A. D. and Pat-terson, G. A. Use of an isolated insitu canine lung perfusion model to

evaluate dopamine clearance by the

lung, 1271

Carfagna, N., Caccia, C., Mantegani, S., Ca-vanus, S., Fornaretto, M. G., Buon-

amici, M., Rossi, A. C., Roncucci, R.

and Fariello, R. G. FCE 23884, Sub-

strate-dependent interaction with

the dopaminergic system. II. Preclin-

ical biochemical studies, 356

Carfagna, N., see Buonamici, M., 345Carini, D. J., see Wong, P. C., 861Carmichael, F. J., Israel, Y., Crawford, M.,

Minhas, K., Saldivia, V., Sandrin, S.,Campisi, P. and Orrego, H. Centralnervous system effects of acetate:

Contribution to the central effects of

ethanol, 403Carminati, P., see Buonamici, M., 345

Carneiro, R. C . G., Cipolla-Neto, J. andMarkus, R. P. Diurnal variation ofthe rat vas deferens contraction in-

duced by stimulation of presynapticnicotinic receptors and pineal func-

tion, 614

Carrageenan, edema, anti-inflammatory ac-

tivity, pergolide (rats), 169

Carruba, M. 0., Nisoli, E., Garosi, V., Pizzi,M., Memo, M. and Spano, P. Char-acterization of monoaminergic recep-tors in hypothalamic nuclei mediat-

ing feeding behavior in rats, 124

Carter, D. E., see Maiorino, R. M., 808

Casler, J. J., see Perkins, W. E., 1004

Castro, C. A., see Broomfield, C. A., 633Catanese, C. A., see Aharony, D., 146

Catecholamines

activation of alpha-i adrenoceptors, dex-medetomidine (rats), 1147

adrenal release, membrane-mediated ef-

fects, steroid 17-a-estradiol (cats),

279morphine administration, liver metallo-

thionein, zinc metabolism (rats), 274

oxidation products of norepinephrine,binding, plasma proteins, 551

tachyphylaxia, beta adrenoceptors, adi-

pose tissue (humans), 317

Cathapermal, S., see Rego, A., 905Catravas, J. D., see Chen, X., 1301Caussade, F., see Dedieu-Chaufour, C., 190Cavanus, S., see Carfagna, N., 356

Cavero, I., see Auchampach, J. A., 961Cavero, I., see Borg, C., 526Cefoclizime, facilitated transport, central

nervous system (rats), 620

Cell cycle, inhibition of proliferation,

HA1077, bovine smooth muscle cells,738

Central nervous system

acetate effects, ethanol (rats, mice), 403facilitated transport of cefodizime (rats),

620

Cerebellum

endothelium-derived relaxing factor, ni-

triC oxide synthase, high and low oxy-gen tensions, 310

Pukinje neurons, sensitivity to neuro-

transmitters, genetically epileptic

rats, 1008

Cerebrospinal fluid

behavioral and neurochemical effects,

medetomidine (rats), 848

facilitated transport ofcefodizime, central

nervous system (rats), 620

Cervini, M. A., see Buonamici, M., 345

C-fiber

capsaicin-sensitive and cholinergic

nerves, functional interactions, bron-

chus (guinea pigs), 104

environmental tobacco smoke, intranasal

capsaicin, symptoms and mediatorrelease (humans), 1323

1410 Index

C-fiber reflex, dynorphin-induced depres-sion, dorsal root potential, spinal

cord (rats), 608

Chance, B., see Argov, Z., 458Chang, C. C., see Hong, S. J., 932Chang, F. W., see Hu, S. C., 1379Chapman, H., see Hieble, J. P., 643Chapnick, B. M., see Joshi, S. N., 71

Chard, P. S., see Bleakman, D., 430Charman, S. A., see Fitzgerald, G. A., 1043

Charman, W. N., see Fitzgerald, G. A., 1043

Charybdotoxiniberiotoxin and, spontaneous motility and

tonus, smooth muscle tissues (guinea

pigs), 439potassium channel blockers and cromak-

aiim, mechanical activity, detrusor

smooth muscle (guinea pigs), 1158

Chau, F., see Starec, M., 745Chauveau, J., see Boulenguez, P., 1360

Chelating agent, location ofpenetration andmetabolic barriers, levobunolol, cor-

neal epithelium (rabbits), 719

Chelating agnets, dithiol, determination andmetabolism (humans), 808

Chemiosmotic hypothesis, ionophore-in-

duced stimulation of renin secretion

(rabbits), 211

Chen, X., Orfanos, S. E., Ryan, J. W.,Chung, A. Y. K., Hess, D. C. andCatravas, J. D. Species variation inpulmonary endothelial aminopepti-

dase P activity, 1301

Ch#{233}ramy,A., see Desce, J. M., 692Cheymol, G., see Weissenburger, J., 871Ch#{233}zalviel,F., see Weissenburger, J., 871Chiba, K., see Echizen, H., 953Chiba, S., see Ren, L.-M., 38Chibana, T., see Noguchi, K., 732Children, stereoselective disposition and

metabolism, disopyramide, 953

Chiu, A. T., see Wong, P. C., 861Chloride, stimulation of sodium transport,

duramycin, colonic epithelia (hu-

mans), 1050

2-Chloroadenosine, role of endothelium, he-

patic vessels, vasoactive agents

(dogs), 71

Chloroethylclonidine, reduction of cardiac

outward currents, alpha-i adrenocep-tor stimulation (rats), 783

CHO cells, cloned and native muscarinicreceptors, binding of AF-DX 384(rats), 601

Choi, H. K., see Park, C. S., 211Cholinesterase, inhibition, chemical oxi-

dant, acetylcholine-induced contrac-tion in trachea (rats), 371

Chromaffin cells, adrenal catecholamine re-lease, membrane-mediated effects,steroid 17-a-estradiol (cats), 279

Chuang, D.-M., see Belcheva, M. M., 302Chung, A. Y. K., see Chen, X., 1301Chung, C. L., see Park, C. S., 211Ciechanowski, D., see Johnson, M. D., 255Cimetidine, oxygen-induced lung damage in

newborns (rats), 444

Cipolla-Neto, J., see Carneiro, R. C. G., 614Cisapride

benzamide-induced gastroprokinesis, se-rotonergic mechanisms (rats), 501

muscarinic receptors, contraction of gas-

tric myocytes (guinea pigs), 1294

Clarke, D. and Garg, L. C. Alpha-i adrener-

gic receptors in renal medullary col-

lecting duct cells, 1081

Clarkson, C. W., see Dise, T. L., 535Cline, W. H., see Luthin, D. R., 1174Cloarec, A., see Dedieu-Chaufour, C., 190Clonidine

antagonism of norepinephrine, mesen-

teric vascular bed (rats), 653

central and peripheral components, in-

duction, postural hypotension (rats),

1221

lack of spinal antianalgesic activity, dy-norphins (mice), 1073

Cocainebenzodiazepine receptors, discrete re-

gions, brain (rats), 574developmental shift from local to central

control, norepinephrine release, car-

diac-sympathetic axis (rats), 976

enhanced inhibitory modulation, cycloox-ygenase products, noradrenergic neu-

rotransmission (rats), 1174

imipramine as a discrimintaive stimulus

(pigeons), 1088

-induced elevation of plasma adrenocor-

ticotropin hormone, corticosterone,

serotonergic neurons (rats), 495sensitization to psychostimulants and

stress, pertussis toxin injection, AiOdopamine region (rats), 916

tracheal epithelial function and, neuro-transmitter receptors (swine), 241

treatment, immune status and survival,

Friend virus (mice), 745Cogan, M. G., Liu, F.-Y., Wong, P. C. and

Timmermans, P. B. M. W. M. Com-parison of inhibitory potency by non-peptide angiotensin II receptor an-tagonists PD123177 and DuP 753 On

proximal nephron and renal trans-port, 687

Collins, A. C., see Marks, M. J., 392Collins, K. A., see Tseng, L. F., 330Collins, P. W., see Perkins, W. E., 1004Colon

arylamine carcinogen N-acetyltransferase

isozymes, tumor target organ cytosols

(hamsters), 699epithelia, stimulation of sodium trans-

port, duramycin (humans), 1050Complements, C5a-induced bronchocon-

striction, inhibition by H1 antagonist

(guinea pigs), 1213

Cone, E. J., see Su, T.-P., 543

Cornea, epithelium, location of penetration

and metabolic barriers, levobunolol

(rabbits), 719

Correa-Sales, C., see Schwinn, D. A., 1147

Correia, J. A., see Fischman, A. J., 1351Corticosterone, cocaine-induced elevation,

plasma adrenocorticotropin hor-mone, serotonergic neurons (rats),

495

Coscia, C. J., see Belcheva, M. M., 302C#{243}te,D., see Levens, N. R., 219

Coudert, B., see Camus, P., 1247Coutant-Perronne, V., Mansour, H., Mar-

quetty, C., Rouveix, B. and Pocidalo,J.-J. Activities of lung NADPH-cy-tochrome C-reductase and of cyto-chrome P-450 peroxidase during theprotection of rat from hyperoxic in-jury by polyriboinosinic acid-polyri-bocytidilic acid, 1059

Craig, C. R., see Gould, E. M., 1008

Vol. 259

Crawford, M., see Carmichael, F. J., 403Cribb, A. E., Grant, D. M., Miller, M. A.

and Spielberg, S. P. Expression ofmonomorphic arylamine N-acetyl-transferase (NAT1) in human leu-kocytes, 1241

Criswell, H. E., see Simson, P. E., 1288

Cromakalimaction of potassium channel openers, sul-

fonylurea receptors (guinea pigs), 566

anti-ischemic actions of mechanisticallydiverse agents, potassium channelblockade (rats), 97

potassium channel blockers and, mechan-ical activity, detrusor smooth muscle

(guinea pigs), 1158Crowley, H. J., see O’Donnell, M., 751Crowley, H. J., Yaremko, B., Selig, W. M.,

Janero, D. R., Burghardt, C., Welton,A. F. and O’Donnell, M. Pharmacol-ogy of a potent platelet-activatingfactor antagonist Ro 24-4736, 78

Cushing, D. J., see Sabouni, M. H., 508Cuthbert, A. W., see Roberts, M., 1050Cyclic AMP

cisapride action on muscarinic receptors,contraction, gastric myocytes (guineapigs), 1294

flerobuterol interactions, beta adrenocep-tors, brain (rats), 414

intracerebroventricular morphine release,

spinal cord, serotonergic mechanism(rats), 1013

water diuretic effect, alpha adrenoceptor

agonist AGN 190851 (rats, dogs,monkeys), 1277

Cyclic GMPendothelin, formation, endothelium-de-

rived relaxing factor-like substance(pigs), 1102

endothelium-derived relaxing factor, ni-tric oxide synthase, bovine cerebel-lum, 310

inhibition of NMDA responses, 1,10-bis(guanidino)decane (rats), 626

vascular nitric oxide-generating activities,organic nitrites and nitrates, 519

Cyclooxygenase, enhanced inhibitory mod-

ulation, noradrenergic neurotrans-mission, mesenteric vasculature(rats), 1174

Cyclosporin A, systemic vascular effects,normotensive rats, 905

Cyronak, M. J., see Mann, W. A., 1231Cytochrome P-450

activities oflung NADPH-cytochrome C-reductase, protection from hepaticinjury, polyriboinosinic acid-polyri-

bocytidilic acid (rats), 1059

oxygen-induced lung damage in newborns

(rats), 444

Cytochrome P45OIIC11, human hepatitisanti-liver kidney microsomes auto-antibodies, liver sections (rats), 1328

Cytochrome P450I1D6, influence of debri-soquine phenotype, quinidine, mexi-letine disposition (humans), 789

Cytochrome P45OIIE1, pyridine effects,liver (rabbits), 470

Cytokines, interleukin la and lfi, transportfrom blood to brain (humans, mice),988

Cytosols, tumor target organ, N-acetyl-transferase isozymes (hamsters), 699

Czartolomna, J., see Voelkel, N. F., 666

1991 Index 1411

Dage, R. C., see French, J. F., 260D’Almeida, M. S. and Lautt, W. W. Gluca-

gon, pharmacodynamics and modu-lation of sympathetic nerve and nor-

epinephrine-induced constrictor re-sponses in the superior mesentericartery of the cat, 118

Daly, J. W., see Nikodijevi#{233}, 0., 286d’Amore, A., Lorenzini, P. and Massotti, M.

Antinociceptive action of opiates andopioid peptides after unilateral mi-

croinjection into area tempestas in

rats, 1308

Damsma, G., Robertson, G. S., Tham, C.-S.and Fibiger, H. C. Dopaminergic reg-

ulation of striatal acetylcholine re-

lease: Importance of Dl and N-methyl-D-aspartate receptors, 1064

Daniel, E. E., see Janssen, L. J., 110Dansette, P. M., see Pons, C., 1328Dart, R. C., see Maiorino, R. M., 808DaSilva, A. M. T., see Abrahams, T. P., 1388

D’Athis P., see Camus, P., 1247Davis, F., see Lamb, R. J., 1165Davis, T. F., see Weber, S. J., 1109

Davy, J.-M., see Weissenburger, J., 871

Dayanithi, G., see Wang, X., 705Deblois, D., see Drapeau, G., 997Debrisoquine, phenotype, quinidine, mexi-

letine disposition (humans), 789

De Brum-Fernandes, A. J., Guillemette, G.,Borgeat, P. and Sirois, P. Specificbinding sites for leukotriene B4 inguinea pig brain membranes, 1035

de Costa, B. R., see Drower, E. J., 725Dedeo�lu, A. and Fisher, L. A. Central and

peripheral injections ofthe 5-HT2 ag-onist, 1-(2,5-diemthoxy-4-iodo-

phenyl)-2-aminopropane, modifycardiovascular function through dif-ferent mechanisms, 1027

Dedieu-Chaufour, C., Hertz, F., Caussade,F. and Cloarec, A. Pharmacological

profile of UP 5’45-52, an original an-tiulcer and antisecretory agent, 190

Degott, C., see Deschamps, D., 894Dehydroabietic acid, reduction of active p-

aminohippurate transport, passive

membrane permeability, renal mem-branes (rats), 156

Delaage, M., see Boulenguez, P., 1360Del Bianco, E., see Geppetti, P., 759Delchambre, J., see Camus, P., 1247Demarinis, R. M., see Hieble, J. P., 643Depalma, P. D., see Brooks, D. P., 1277de Pascual, R., see Lopez, M. G., 279Deprenyl, locomotor activity, dopaminergic

neurotransmission, nigral dopamineneurons (rats), 841

Desce, J. M., Godeheu, G., Galli, T., Artaud,F., Ch#{233}ramy, A. and Glowinski, J.Presynaptic facilitation of dopaminerelease through D,L-a-amino-3-hy-droxy-5-methyl-4-isoxazole propio-

nate receptors on synaptosomes fromthe rat striatum, 6, 92

Deschamps, D., Fisch, C., Fromenty, B.,Berson, A., Degott, C. and Pessayre,D. Inhibition by salicylic acid of theactivation and thus oxidation of longchain fatty acids. Possible role in thedevelopment of Reye’s syndrome, 894

Desforges, B., see Starec, M., 745Desipramine, imipramine as a discrimina-

tive stimulus (pigeons), 1088

Desmethoxyverapamil, binding to calcium

channels, guanine nucleotide-bindingproteins, vascular smooth muscle(rats), 164

Dexmedetomidine, activation of alpha-iadrenoceptors (rats), 1147

Diazepam, inhibitory action of peripheral-type benzodiazepines, dopamine re-lease, PC12 cells, 484

Dieter, J. P., see Lam, S. C. T., 1371Dihydrexidine, D, and D2 dopamine recep-

tors, spontaneous blink rate (mon-

keys), 595

Diltiazem, vascular actions ofTA 3090, fem-

oral and coronary arteries (dogs), 639i-(2,5-Dimethoxy-4-iodophenyl)-2-amino-

propane, central and peripheral in-jections, cardiovascular function

modification (rats), 1027

Discriminative stimulus

imipramine (pigeons), 1088

quipazine and l-5-hydroxytryptophan, se-

rotonin binding sites (pigeons), 772

Dise, T. L., Stolfi, A., Clarkson, C. W. and

Pickoff, A. S. Rate-dependent effectsof lidocaine on his-purkinje conduc-

tion in the intact neonatal heart-

characterization and amplification

by N-acetylprocainamide, 535

Disopyramide, stereoselective disposition

and metabolism, pediatric patients,953

Dithiol, chelating agents, determination and

metabolism (humans), 808Diuresis

renal effects and elimination, sulotroban

(dogs), 1231

water diuretic effect, alpha adrenoceptor

agonist AGN 190851 (rats, dogs,

monkeys), 1277

Dixon, K. F., see Mays, D. C., 1261

Dixon, W., see Lopez, M. G., 279Dizocilpine, anticonvulsant activity, 5-ami-

nocarbonyl-iO,i1-dihydro-5H-di-

benz[a,djcyclohepten -5,10-imine

(mice, rats), 30

DNA, complementary, ligand-binding prop-erties, tachykinin receptors (rats),968

Dodge, A. L., see Su, T.-P., 543

DO!, increased renin secretion and bloodpressure, 5-HT2 receptors (rats), 58

L-Dopa, D1 and D2 agonists and antagonists,

dyskinesia, i-methyl-4-phenyl-i,2,3,

6-tetrahydropyridine (monkeys), 409

DopamineAlO region, pertussis toxin, sensitization

to psychostimulants and stress (rats),916

benzodiazepine receptors, cocaine, dis-

crete regions of brain (rats), 574

clearance, lung perfusion model (dogs),1271

D1 and D2 agonists and antagonists, dys-kinesia produced by L-dopa, 1-methyl-4-phenyl-i,2,3,6-tetrahydro-

pyridine (monkeys), 409

deprenyl, locomotor activity, nigral do-pamine neurons (rats), 841

3,4-methylenedioxymethamphetamine-

induced release, microdialysis studies(rats), 820

neurotransmission, effect of metaphit,

striatal slices (rats), 1188

release, inhibitory action of peripheral-

type benzodiazepines, PC12 cells, 484release through D,L-a-amino-3-hydroxy-

5-methyl-4-isoxazole propionate re-ceptors, synaptosomes, striatum

(rats), 692

substrate-dependent interaction, FCE

23884 (mice, rats, dogs, marmosets,

monkeys), 345, 356

Dorn, G. W., II. Mechanism for homologousdownregulation of thromboxane A2

receptors in cultured human chronicmyelogenous leukemia (K562) cells,228

Dorsal root ganglion, modulation of GABAreceptor-channel complex, alcohols(rats), 235

Downing, G., see Thibeault, D. W., 444Drapeau, G., Deblois, D. and Marceau, F.

Hypotensive effects of Lys-des-Arg�-

bradykinin and metabolically pro-tected agonists of B1receptors for

kinins, 997

Drieman, J. C. and Thijssen, H. H. W. Renalselective N-acetyl-L--y-glutamyl pro-

drugs. II!. N-Acetyl-L--y-glutamyl-4’-aminowarfarin is not targeted to thekidney but is selectively excreted into

the bile, 766Drower, E. J., Stapelfeld, A., Rafferty, M.

F., de Costa, B. R., Rice, K. C. andHammond, D. L. Selective antago-nism by naltrindole of the antinoci-

ceptive effects of the Delta opioid ag-onist cyclic[D-penicillamine2-D-penicillaminet]enkephalin in the rat,

725Duckles, S. P., see Massamiri, T., 22

DuP 532, pharmacology (rats), 861DuP 753, PD123177 and, inhibitory po-

tency, proximal nephron and renaltransport (rats), 687

Dupront, A., see Camus, P., 1247

Dwyer, T. M., see Farley, J. M., 241Dynorphin

-induced depression of dorsal root poten-

tial, spinal cord (rats), 608

lack of spinal antianalgesic activity(mice), 1073

responses of extrapyramidal and limbic

neuropeptides, fenfluramine admin-

istration (rats), 1197

Dyskinesia, D1 and D2 agonists and antag-

onists, L-dopa, 1-methyl-4-phenyl-1,

2,3,6-tetrahydropyridine (monkeys),

409

Dzwonczyk, S., see Sargent, C. A., 97

E4080, vasodilating actions, ionic currents,

smooth muscle cells of portal vein(rabbits), 1396

Ebersole, B. J. and Molinoff, P. B. Inhibi-

tion of binding of [3H]PN200-110 tomembranes from rat brain and heart

by ascorbate is mediated by lipid per-

oxdiation, 337

Echizen, H., Takahashi, H., Nakamura, H.,Ochiai, K., Chiba, K., Koike, K.,Ogata, H. and Ishizaki, T. Stereose-lective disposition and metabolism ofdisopyramide in pediatric patients,

953

Edwards, M. L., see Reynolds, I. J., 626

Edwards, R., see Hieble, J. P., 643Edwards, R. M., see Brooks, D. P., 1277Ehrlich ascites tumor cells, nitrobenzyl-

1412 Index Vol. 259

thioguanosine, nucleoside transport

mechanisms, 799

Eichelbaum, M., see Turgeon, J., 789

Eikenburg, D. C. Age-related changes in

vascular sympathetic neurotransmis-sion in the rat kidney, 176

Elebring, T., see Engberg, G., 841Electroencephalography, delta wave activ-

ity, naloxone, dose-dependent in-

crease (rats), 464Electromechanical coupling, ion channels in

bronchi (dogs), 110Electrophysiology

actions of BRB-!-28, myocardial tissues(dogs), 558

dynorphin-induced depression, dorsal

root potential, spinal cord (rats), 608rate-dependent effects of lidocaine, His-

Purkinje conduction, neonatal heart(dogs), 543

sodium channel blockers, left atrium(guinea pigs), 884

Eleff, S., see Argov, Z., 458Elmaleh, D. R., see Fischman, A. J., 1351

Elsworth, J. D., Lawrence, M. S., Roth, R.

H., Taylor, J. R., Mailman, R. B.,

Nichols, D. E., Lewis, M. H. and Red-

mond, D. E., Jr. D1 and D2 Dopaminereceptors independently regulatespontaneous blink rate in the vervet

monkey, 595Endothelin, cyclic GMP levels, formation,

endothelium-derived relaxing factor-

like substance (pigs), 1102

Endothelin-3, effects on renal function(dogs), 1256

Endothelium

-dependent relaxation, serotonin, bovinecoronary artery, 1316

responses to hepatic vessels, vasoactive

agents (dogs), 71

selective transport of anti-transferrin re-

ceptor antibody, blood-brain barrier(mice, rats, humans, cattle), 66

Endothelium-derived relaxing factorinhibitor N#{176}-monomethyl L-arginine, ef-

fects of guanidino compounds (rats),

490NG�monomethyl�L�arginine�induced

pressor response, developmental andestablished stages, spontaneously hy-pertensive rats, 52

nitric oxide synthase, bovine cerebellum,high and low oxygen tensions, 310

ultraviolet irradiation of solutions, re-

sponses of aorta, nitric oxide and su-

peroxide (rabbits), 1140vascular actions of TA 3090 (dogs), 639

Endotoxin, hypotensive effects of lys-des-

arg�-bradykinin, metabolically pro-

tected agonists, B1 receptors for kin-ins (rabbits), 997

Energy metabolism, intra-arterial epineph-rine, exercising gastrocnemius mus-cle (rabbits), 458

Engberg, G., Elebring, T. and Nissbrandt,H. Deprenyl (selegiline), a selectiveMAO-B inhibitor with active metab-olites; effects on locomotor activity,

dopaminergic neurotransmisssion

and firing rate of nigral dopamine

neurons, 841Engel, F., see Weissenburger, J., 871

Engfeldt, P., see Arner, P., 317Enkephalin, leucine, metabolism and poor

membrane permeation, intestinal ab-sorption (rats), 139

[D-pen2,D-pen5]Enkephalin

distribution and analgesia (mice), 1109selective antagonism by naltrindole

(rats), 725Epilepsy

anticonvulsant activity, 5-aminocar-bonyl-10,11-dihydro-5H-dibenz[a,d]

cyclohepten -5,10-imine (mice, rats),30

sensitivity of cerebellar Purkinje neurons,neurotransmitters (rats), 1008

Epinephrine

intra-arterial, energy metabolism, exer-

cising gastrocnemius muscle (rab-

bits), 458

responses, desensitization by imidazoline,vas deferens (rats), 1182

Epitheliumacetylcholine-induced contraction, chem-

ical oxidant, trachea (rats), 371colonic, stimulation of sodium transport,

duramycin (humans), 1050cornea!, location of penetration and met-

abolic barriers, levobunolol (rabbits),719

inhibition of airway smooth muscle tone,

phorbol ester, trachea (guinea pigs),198

Ergoline, FCE 23884, substrate-dependentinteraction, dopaminergic system(mice, rats, dogs, marmosets, mon-keys), 345, 356

Ertzbischoff, 0., see Weissenburger, J., 871Esophagus, lower sphincter, bradykinin and

bradykinin analogs (opossums), 26517-a-Estradiol, adrenal catecholamine re-

lease, membrane-mediated effects

(cats), 279

Ethanolcentral nervous system effects, acetate

(rats, mice), 403-induced alterations of thermoregulation,

serotonergic involvement, long-sleep

and short-sleep mice, 833inhibition ofcalcium currents and peptide

release, neurohypophysial terminals

(rats), 705modulation of GABA receptor-channel

complex (rats), 235potentiation of GABA-mediated inhibi-

tion, inferior colliculus (rats), 1288

Eye

corneal epithelium, location of penetra-tion and metabolic barriers, levobu-

nolol (rabbits), 719spontaneous blink rate, D1 and D2 dopa-

mine receptors (monkeys), 595

Facci, L., see Skaper, S. D., 452Fanciullacci, M., see Geppetti, P., 759Fariello, R. G., see Buonamici, M., 345Fariello, R. G., see Carfagna, N., 356Farley, J. M., Adderholt, J. G. and Dwyer,

T. M. Cocaine and tracheal epithelialfunction: Effects on short circuit cur-rent and neurotransmitter receptors,241

Fatty acids, long chain, oxidation, inhibitionby salicylic acid (mice), 894

FCE 23884, substrate-dependent interac-

tion, dopaminergic system (mice,rats, dogs, marmosets, monkeys),345, 356

Fedele, E., see Bonanno, G., 1153

Feinberg, H., see Lam, S. C. T., 1371Feldman, P. L., see James, M. K., 712Fenfluramine, responses of extrapyramidal

and limbic neuropeptides (rats), 1197Fentanyl, opioid receptor activity, GI

870MB (guinea pigs, rats, mice), 712

Fibiger, H. C., see Damsma, G., 1064

Fibrin, platelet-rich clots, dissociation, plas-minogen activators and antiplateletagents (humans), 1371

Finger, A. V., see Broomfield, C. A., 633

Fisch, C., see Desehamps, D., 894

Fischman, A. J., Alpert, N. M., Livni, E.,Ray, S., Sinclair, I., Elmaleh, D. R.,

Weiss, S., Correia, J. A., Webb, D.,

Lisa, R, Straum, H. W. and Rubin,R. H. Pharmacokinetics of 18F-la-beled fluconazole in rabbits with can-didal infections studied with positronemission tomography, 1351

Fiset, C., see Turgeon, J., 789Fisher, L. A., see Dedec�lu, A., 1027Fitzgerald, G. A., Lupinetti, M., Charman,

S. A. and Charman, W. N. Presys-

temic acetylation of platelets by as-pirin: Reduction in rate ofdrug deliv-ery to improve biochemical selectiv-

ity for thromboxane A2, 1043

Flecainide, arrhythmogenic activities, atri-oventricular block (dogs), 871

Fleming, W. W., see Gould, E. M., 1008

Fleming, W. W., see Kong, J.-Q., 653Fleming, W. W., see Leedham, J. A., 295Fleming, W. W., see Taylor, D. A., 1084

Flerobuterol, interactions with beta ache-noceptors, brain (rats), 414

Fluconazole, pharmacokinetics of ‘8F-label-ing, candidal infections, positron

emission tomography (rats, rabbits),1351

Fluorine- 18 fluconazole, pharmacokinetics,candidal infections (rats, rabbits),

1351Foegh, M. L., see Rego, A., 905Folco, G. C., see Geppetti, P., 759Fontana, G., see Bonanno, G., 1153

Fornaretto, M. G., see Carfagna, N., 356

Forskolin, inhibition of adenylate cyclase,adenosine receptor-mediated relaxa-tion, coronary artery (pigs), 508

Foucart, S., see Bleakman, D., 430

Foucher, P., see Camus, P., 1247FPL 64176, new site for activation, cardiac

calcium channels (rats), 982Franklin, S. R., see Tang, A. H., 248

Fraser, D. G. and Regal, J. F. Recombinanthuman C5a-induced bronchocon-striction in the guinea pig Inhibitionby an H1 antagonist after depletionofcirculating granulocytes and plate-lets, 1213

Fredrickson, T. A., see Brooks, D. P., 1277French, J. F., Lambert, L. E. and Dage, R.

C. Nitric oxide synthase inhibiots in-hibit interleukin lfl-induced depres-sion of vascular smooth muscle , 260

French, T. A. and Weiner, N. Serotoninergicinvolvement in ethanol-induced al-tertions of thermoregulation in long-sleep and shrot-sleep mice, 833

Friden, P. M., see Pardridge, W. M., 66

Fridl, A., see Georg, A., 479Friedman, E., see Johnson, M. D., 255Friend virus, immune status and survival,

1991 Index 1413

opiate and cocaine treatment (mice),745

Fromenty, B., see Deschamps, D., 894Fujimori, K., see Ohara-!maizumi, M., 484Fujimoto, J. M., see Rady, J. J., 1073

Fujita, N., see Yamazaki, J., 52Fung, H.-L., see Kowaluk, E. A., 519Furchgott, R. F., see Matsunaga, K., 1140

Furukawa, T., see Katsuragi, T., 513

Furukawa, Y., see Ren, L.-M., 38

Gaddis, R. R., see Linnik, M. D., 501Gaginella, T. S., see Perkins, W. E., 1004Galli, T., see Desce, J. M., 692

Gao, X.-M., see Belcheva, M. M., 302Garcia, A. G., see Lopez, M. G., 279Garcia, M. L., see Suarez-Kurtz, G., 439Garg, L. C., see Clarke, D., 1081Garosi, V., see Carruba, M. 0., 124

Garvey, J. S., see Hidalgo, J., 274Gasiecki, A. F., see Perkins, W. E., 1004

Gastroprokinesis, benzamide-induced, se-

rotonergic mechanisms (rats), 501Gellai, M., see Brooks, D. P., 1277

Gemignani, A., see Bonanno, G., 1153Gene, -mediated pharmacodynamics, effect

of ketoconazole, methylprednisolone

pharmacokinetics (rats), 826Georg, A. and Friedl, A. Identification and

characteization of two Sigma-like

binding sites in the mouse neuro-

blastoma x rat glioma hybrid cell lineNG1O8-15, 479

Gepirone, imipramine as a discriminativestimulus (pigeons), 1088

Geppetti, P., Del Bianco, E., Tramontana,M., Vigano, T., Folco, G. C., Maggi,C. A., Manzini, S. and Fanciullacci,M. Arachidonic acid and bradykininshare a common pathway to releaseneuropeptide from capsaicin-sensi-tive sensory nerve fibers of the guineapig heart, 759

Gerber, N., see Mays, D. C., 1261

GI 870MB, opioid receptor activity (guineapigs, rats, mice), 712

Gibb, J. W., see Hanson, G. R., 1197

Gibson, V. A., see Miller, J. H., 601

Gigo, V., see Herbert, J. M., 44

Gigu#{232}re,R., see Turgeon, J., 789Gilbert, M., see Turgeon, J., 789Gillis, R. A., see Abrahams, T. P., 1388

Giralt, M., see Hidalgo, J., 274

Gleason, M. M. and Hieble, J. P. Ability ofSK&F 104078 to identify alpha-2adrenoceptor subtypes in NCB2O

cells and guinea pig lung, 1124Glibenclamide

action of potassium channel openers, sul-fonylurea receptors (guinea pigs), 566

reduction of infarct size by aprikalim, ab-sence of hemodynamic changes(dogs), 961

tolbutamide and, hyperpolarization of de-nervated skeletal muscle, lemakalim

(mice), 932vasorelaxation, nicorandil, potassium

channel opening (rats), 526Glioma, rat, mouse neuroblastoma hybrid

cell line, sigma-like bindig sites, 479Glomerular filtration rate, renal effects and

elimination, sulotroban (dogs), 1231

Glowinski, J., see Desce, J. M., 692

Glucagon, pharmacodynamics, sympatheticnerve and norepinephrine-induced

constrictor responses, superior mes-

enteric artery (cats), 118Glucocorticoids

methylprednisolone pharmacokinetics,effect of ketoconazole (rats), 826

morphine administration, liver metallo-

thionein, zinc metabolism (rats), 274

Glutamateheterogeneity of NMDA receptor iono-

phore complex, brain (rats), 86metabotropic excitatory amino acid re-

ceptor agonist, intrastriatal injection,contralateral turning (rats), 1366

sensitivity of cerebellar Purkinje neurons,

genetically epileptic rats, 1008

Glyburide, potassium channel blockers andcromakalim, mechanical activity, de-trusor smooth muscle (guinea pigs),

1158

Glycine, GABA-mediated inhibition, poten-tiation by ethanol, inferior colliculus(rats), 1288

Godeheu, G., see Desce, J. M., 692

Goeders, N. E. Cocaine differentially affectsbenzodiazepine receptors in discreteregions of the rat brain: Persistence

and potential mechanisms mediating

these effects, 574

Goldberg, S. R., see Lamb, R. J., 1165Goldstein, R. S., see Mann, W. A., 1231Gomez-Mancilla, B. and B#{233}dard,P. J. Effect

ofD1 and D2 agonists and antagonistson dyskinesia produced by L-DOPAin 1-methyl-4-phenyl-1,2,3,6-tetra-

hydropyridine-treated monkeys, 409

Gould, E. M., Craig, C. R., Fleming, W. W.

and Taylor, D. A. Sensitivity of cer-

ebellar Purkinje neurons to neuro-

transmitters in genetically epileptic

rats, 1008

Goyal, R. K., see Saha, J. K., 265

G proteinsdesmethoxyverapamil binding to calcium

channels, vascular smooth muscle

(rats), 164

ligand-binding properties, tachykinin re-

ceptors (rats), 968

reduced function in desensitized aorta

(rats), 255

up-regulation of sigma opioid receptors,

neuroblastoma hybrid cells, 302Grant, D. M., see Cribb, A. E., 1241Grant, T. L. and Zuzack, J. S. Effects of K�

channel blockers and cromakalim

(BRL 34915) on the mechanical ac-

tivity of guinea pig detrusor smooth

muscle, 1158

Granulocytes, depletion, C5a-induced bron-

choconstriction, inhibition by H1 an-

tagonist (guinea pigs), 1213Grasing, K. and Szeto, H. Naloxone causes

a dose-dependent increase in total

power and Delta wave activity in the

EEG of opioid-naive rats, 464Graybill, S. C., see Webb, R. L., 1203Grech-B#{233}langer, 0., see Turgeon, J., 789

Greene, D. L., see Weber, S. J., 1109

Gregeois, J., see Pons, C., 1328

Gross, G., see Wang, X.-L., 783Gross, G. J., see Auchampach, J. A., 961Grover, G. J., see Sargent, C. A., 97

GTP analogs, substance P binding, high-affinity NK-1 receptors, lung mem-

branes (guinea pigs), 146

Guanethidine, central and peripheral corn-

ponents, induction, postural hypo-

tension (rats), 1221

Guanidino compounds, endothelium-de-

rived relaxing factor, inhibitor NG�

monomethyl L-arginine (rats), 490Guanylate cyclase, formation of endothe-

hum-derived relaxing factor-like sub-

stance, endothelin, increased cyclic

GMP levels (pigs), 1102

Guillemette, G., see De Brum-Fernandes, A.J., 1035

Gund, T. M., see Su, T.-P., 543

HA1O77, inhibition of proliferation, bovine

vascular smooth muscle cells, 738

Ha, S. K., see Park, C. S., 211Hall, S. D., see Rudy, A. C., 1133

Haloperidol, sigma ligands, contractile re-

sponses (rats), 22

Hamdi, A., see Rice, P. J., 1182

Hammond, D. L., see Drower, E. J., 725

Hammond, J. R. Comparative pharmacol-ogy of the nitrobenzylthioguanosine-sensitive and -resistant nucleoside

transport mechanisms of Ehrlich as-

cites tumor cells, 799Hanano, M., see Matsushita, H., 620Hanson, G. R., Singh, N., Bush, L. and

Gibb, J. W. Response of extrapyra-midal and limbic neuropeptides to

fenfluramine administration: Corn-parison with methamphetamine,1197

Hardin, J. C., see Rice, P. J., 1182

Hart, S. D., see Wong, P. C., 861

Hasler, W. L., Heldsinger, A. and Owyang,

C. Cisapride acts of muscarinic (glan-dular M2) receptors to induce con-traction of isolated gastric myocytes:

Mediation via a calcium-phosphoi-nositide pathway, 1294

Hattori, R., see Shirotani, M., 738

Haughey, D. B. and Jusko, W. J. Effect ofketoconazole on methylprednisolonepharmacokinetics and receptor/gene-

mediated pharmacodynamics, 826

Heartarrhythmogenic activities, antiar-

rhythmic drugs, atrioventricular

block (dogs), 871beta-2 adrenoceptor stimulation, intracor-

onary procaterol, myocardial ische-mia (dogs), 732

calcium channel activation, nondihydro-

pyridine FPL 64176 (rats), 982

capsaicin-sensitive sensory nerve fibers,neuropeptide release, arachidonicacid and bradykinin (guinea pigs),

759cardiac outward current reduction, alpha-

1 adrenoceptor stimulation (rats),783

cardiac-sympathetic axis, developmental

shift, norepinephrine release and co-

caine (rats), 976cardiovascular effects of adenosine A2 ag-

onists, structurally distinct ligands

(rats), 1203

differential inhibition of neuropeptide Y,chronotropic and inotropic re-sponses, atrium (dogs), 38

inhibition of binding to PN200-1i0 to

membranes, ascorbate, lipid peroxi-dation (rats), 337

muscarinic stimulation, adenylate cyclase

activity, olfactory bulb (rats), 680

1414 Index Vol. 259

myocardial tissues, electrophysiological

actions, BRB-I-28 (dogs), 558

neonatal, rate-dependent effects, lido-caine (dogs), 535

vasorelaxation, nicorandil, potassiumchannel opening (rats), 526

Heart rate

development of tolerance to nicotine, gen-otype influences (mice), 392

modification of cardiovascular function,

1-(2,5-dimethoxy-4-iodophenyl)-2-

aminopropane (rats), 1027Hem, D. W., Rustan, T. D., Bucher, K. D.

and Miller, L. S. Polymorphic andmonomorphic expression of arylam-

me carcinogen N-acetyltransferase

isozymes in tumor target organ cyto-sols of Syrian hamsters congenic at

the polymorphic acetyltransteraseloucs, 699

Heldsinger, A., see Hasler, W. L., 1294Helke, C. J., Thor, K. B. and Phillips, E. T.

5-Hydroxytryptamine1c/2 agonists in

the thoracic spinal cord: Cardiovas-cular effects and binding sites in the

intermediolateral cell column, 1335

Henningfield, J. E., see Lamb, R. J., 1165

Hepatitis, anti-liver kidney microsomes

autoantibodies, liver sections (rats),

1328

Herbert, J. M., Bernat, A., Valette, G., Gigo,V., Lale, A., Laplace, M. C., Lespy,L., Savi, P., Maffrand, J. P. and LeFur, G. Biochemical and pharmaco-logical activities of SR 27417, ahighly potent, long-acting platelet-

activating factor receptor antagonist,44

Herblin, W. F., see Wong, P. C., 861Hersh, L. B., see Weber, S. J., 1109

Hertz, F., see Dedieu-Chaufour, C., 190

Hess, D. C., see Chen, X., 1301

Hidalgo, J., Giralt, M., Garvey, J. S. andArmario, A. Effect of morphine ad-ministration of rat liver metallothi-onein and zinc metabolism, 274

Hieble, J. P., see Brooks, D. P., 1277

Hieble, J. P., see Gleason, M. M., 1124Hieble, J. P., Sulpizio, A. C., Edwards, R.,

Chapman, H., Young, P., Roberts, S.P., Blackburn, T. P., Wood, M. D.,Shah, D. H., Demarinis, R. M. andRuffolo, R. R., Jr. Additional evi-dence for functional subclassificationof Alpha-2 adrenoceptors based on a

new selective antagonist, SK&F104856, 643

Hillard, C. J. and Pounds, J. J. [3H]Tetra-phenylphosphonium accumulation in

cerebral cortical sysanptosomes as ameasure of nicotine-induced changes

in membrane potential, 1118

Himes, C. S., see Tang, A. H., 248

Hippocampus, pyramidal neurons, activa-tion of NMDA receptors, death re-duction by monosialogangliosides(rats), 452

Histamine, C5a-induced bronchonconstric-tion, inhibition by H1 antagonist(guinea pigs), 1213

Hladky, S. B., see Roberts, M., 1050

Ho, P. M., see Tang, A. H., 248Hollingsworth, P. J., see Walker, E. A., 772Holtzman, S. G., see Paronis, C. A., 582Homberg, J. C., see Pons, C., 1328

Honda, K., see Miyata, K., 15, 815Honeyman, T. W., see Park, C. S., 211Hong, C. D., see Park, C. S., 211Hong, S. J. and Chang, C. C. Hyperpolari-

zation of denervated skeletal muscleby lemakalim and its antagonism byglybenclamide and tolbutamide, 932

Hornby, P. J., see Abrahams, T. P., 1388

Horwitz, S. B., see Ringel, I., 855Hruby, V. J., see Weber, S. J., 1109Hsu, W. M., see Hu, S. C., 1379Hu, S. C., Chang, F. W., Sung, Y. J., Hsu,

W. M. and Lee, E. H. Y. Neurotoxiceffects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the substantia

nigra and the locus ceruleus inBALB/c mice, 1379

Hussain, M. A., see Aungst, B. J., 139l-5-Hydroxytryptophan, quipazine and, dis-

criminative-stimulus effects, sero-tonin binding sites (pigeons), 772

Hypertension

cardiovascular effects of adenosine A2 ag-onists, ligands (rats), 1203

enhanced inhibitory modulation, cycloox-ygenase products, noradrenergic neu-

rotransmission (rats), 1174

inhibition of thromboxane synthetase,angiotensin-converting enzyme in-

hibitor (rats), 219NG�monomethyl�L�arginine.induced

pressor response, developmental andestablished stages, spontaneously hy-pertensive rats, 52

pharmacology of DuP 532 (rats), 861systemic vascular effects, cyclosporin A

treatment, normotensive rats, 905

Hypokalemia, arrhythmogenic activities,antiarrhythmic drugs, atrioventricu-

lar block (dogs), 871Hypotension

lys-des-ar�-bradykinin, metabolicallyprotected agonists, B1 receptors forkinins (rabbits), 997

postural, central and peripheral compo-nents, frequency selectivity (rats),1221

Hypothalamus, nuclei, monoaminergic re-

ceptors, feeding behavior (rats), 124Hypothermia, development of tolerance to

nicotine, genotype influences (mice),392

Hypoxia, endothelium-derived relaxing fac-

tor, nitric oxide synthase, bovine cer-

ebellum, 310

Iberiotoxin, charybdotoxin and, sponta-neous motility and tonus, smoothmuscle tissues (guinea pigs), 439

Ibuprofen

effects of endothelin-3, renal function(dogs), 1256

stereoselective metabolism (humans),

1133!ga, T., see Matsushita, H., 620!komi, F., Kawai, Y. and Ohhashi, T. Beta-

1 and Beta-2 adrenoceptors mediate

smooth muscle relaxation in bovineisolated mesenteric lymphatics, 365

Ileumaction of potassium channel openers, sul-

fonylurea receptors (guinea pigs), 566ATP-evoked ATP release system (guinea

pigs), 513benzamide-induced gastroprokinesis, se-

rotonergic mechanisms (rats), 501

calcitonin gene-related peptide, longitu-dinal muscle and myenteric plexus

(guinea pigs), 947circular muscle, bradykinin, pertussis

toxin-insensitive biphasic response(guinea pigs), 659

Imidazoline, desensitization of epinephrineresponses, vas deferens (rats), 1182

Imipramine, discriminative stimulus (pi-geons), 1088

Immunofluorescence, human hepatitis anti-

liver kidney microsomes, liver sec-tions (rats), 1328

Indomethacinenhanced inhibitory modulation, cycloox-

ygenase products, noradrenergic neu-rotransmission (rats), 1174

plasminogen activators and antiplatelet

agents, rapid dissociation, platelet-rich fibrin clots (humans), 1371

Ingi, T., Kitajima, Y., Minamitake, Y. andNakanishi, S. Characterization of li-gand-binding properties and selectiv-

ities of three rat tachykinin receptorsby transfection and functionalexpression of their cloned cDNAs inmammalian cells, 968

Inotropy, positive, low concentrations, stro-phanthidin (sheep), 182

Inoue, D., see Shirayama, T., 884Inoue, K., see Ohara-Imaizumi, M., 484Inoue, M., see Shirayama, T., 884Insulin, chronic treatment, sympathetic ac-

tivation (rats), 131Interleukin la, transport from blood to

brain (humans, mice), 988

Interleukin 1�-induced depression of vascular smooth

muscle, nitric oxide synthase inhibi-tors (rats), 260

transport from blood to brain (mice), 988Intestine

absorption, metabolism and poor mem-

brane permeation, leucine enkepha-lin (rats), 139

small, sulfonylurea receptors, action ofpotassium channel openers (guineapigs), 566

Ion currents, vasodilating actions of E4080,smooth muscle cells, portal vein (rab-bits), 1396

!onophore

-induced stimulation of renin secretion,chemiosmotic hypothesis (rabbits),211

NMDA receptor, heterogeneity, brain(rats), 86

Iqbal, A., see Rubanyi, G., 639Isaac, L., see Stewart, P., 608Ischemia

reduction ofdeath of hippocampalpyram-idal neurons, monosialogangliosides(rats), 452

reduction of infarct size by aprikalim, ab-sence of hemodynamic changes(dogs), 961

Ishii, K., Warner, T. D., Sheng, H. andMurad, F. Endothelin increasescyclic GMP levels in LLC-PK1 pro-cine kidney epithelial cells via for-mation of an endothelium-derived re-laxing factor-like substance, 1102

Ishizaki, T., see Echizen, H., 953Isobutyl nitrite, vascular nitric oxide-gen-

1991 Index 1415

erating activities, organic nitrites andnitrates, 519

Isoproterenol, chronic insulin treatment,

sympathetic activation (rats), 131Israel, Y., see Carmichael, F. J., 403Ito, H., see Miyata, K., 15, 815Itoh, H., see Bu#{241}ag,R. D., 131Ivins, K. J. and Molinoff, P. B. Desensiti-

zation and down-regulation of 5-HT2

receptors in P11 cells, 423Iwai, A., see Miyata, K., 15

Jackman, S., see Wonnacott, S., 387Jacobson, A. E., see Reith, M. E. A., 1188

Jacobson, K. A., see Nikokijevi#{233}, 0., 286James, M. K., Feldman, P. L., Schuster, S.

V., Bilotta, J. M., Brackeen, M. F.and Leighton, H. J. Opioid receptoractivity of GI 870MB, a novel ultra-short acting analgesic, in isolated tis-sues, 712

Janero, D. R., see Crowley, H. J., 78

Janssen, L. J. and Daniel, E. E. Depolarizingagents induce oscillations in canine

bronchial smooth muscle membrane

potential: Possible mechanisms, 110

Jaouen, M., see Pons, C., 1328Jeannin, L., see Camus, P., 1247Johns, R. A., see Rengasamy, A., 310Johnson, M. D., Wang, H.-Y., Ciechan-

owski, D. and Friedman, E. ReducedG protein function in desensitized rataorta, 255

Jones, P. H., see Perkins, W. E., 1004Jones, S. M., see Rogawski, M. A., 30Joshi, S. N., Lonigro, A. J., Secrest, R. J.

and Chapnick, B. M. Role of endo-thelium in responses of isolated he-

patic vessels to vasoactive agents, 71Jusko, W. J., see Haughey, D. B., 826

Kaczorowski, G. J., see Suarez-Kurtz, G.,439

Kageyama, M., Mori, T., Yanagisawa, T.and Taira, N. Is staurosporine a spe-cific inhibitor of protein kinase C in

intact porcine coronary arteries, 1019

Kagey-Sobotka, A., see Bascom, R., 1323Kajioka, S., see Kamouchi, M., 1396Kalivas, P. W., see Steketee, J. D., 916Kamato, T., see Miyata, K., 15, 815Kamouchi, M., Xiong, Z., Teramoto, N.,

Kajioka, S., Okabe, K. and Kitamura,K. Ionic currents involved in vasodi-lating actions of E4080, a newly syn-tesized bradycardia-inducing agent,in dispersed smooth muscle cells ofthe rabbit portal vein, 13, 96

Kao, J., see Mann, W. A., 1231Karasawa, Y., see Ren, L.-M., 38

Kastin, A. J., see Banks, W. A., 988Katsume, H., see Shirayama, T., 884Katsuragi, T., Tokunaga, T., Ogawa, S.,

Soejima, 0., Sato, C. and Furukawa,T. Existence ofATP-evoked ATP re-

lease system in smooth muscles, 513

Katsuyama, Y., see Miyata, K., 15, 815Katz, J. L., see Lamb, R. J., 1165Kawaguchi, Y., see Matsushita, H., 620Kawai, C., see Shirotani, M., 738Kawai, Y., see Ikomi, F., 365K562 cells, homologous downregulation,

thromboxane A2 receptors, 228Kerr, J. E., see Levy, A. D., 495Ketoconazole, methylprednisolone phar-

macokinetics, receptor/gene-me-

diated pharmacodynamics (rats), 826Kidney

N-acetyl-L--y-glutamyl prodrugs (rats),

766age-related changes, vascular sympathetic

neurotransmission (rats), 176

alpha-2C adrenoceptors, OK cell line, 323arylamine carcinogen N-acetyltransferase

isozymes, tumor target organ cytosols

(hamsters), 699detection of human hepatitis anti-liver

microsomes autoantibodies, liver sec-tions (rats), 1328

elimination of sulotroban (dogs), 1231

excretion, zidovudine, inhibition of glu-

curonidation (rats, humans), 1261function, effects of endothelin-3 (dogs),

1256

mechanism ofvancomycin transport (rab-

bits), 1283

medullary collecting duct cells, alpha-iadrenergic receptors (rabbits), 1081

proximal nephron and renal transport,inhibitory potency, PD123177 and

DUP 753 (rats), 687pulmonary endothelial aminopeptidase P

activity, species variation (cattle, hu-mans, rats, rabbits, cats, minipigs),

1301

release of platelet-activating factor, no

link to prostaglandin production

(rats), 590renal membranes, dehydroabietic acid, p-

aminohippurate transport (rats), 156

Kim, S. G., Philpot, R. M. and Novak, R. F.Pyridine effects on P450I!E1, IIBand IVB expression in rabbit liver:Characterization of high- and low-affinity pyridine N-oxygenases, 470

KininsB1 receptors, hypotensive effects, lys-des-

arg�-bradykinin (rabbits), 997

pertussis toxin-insensitive biphasic re-sponse, bradykinin, circular muscleof ileum (guinea pigs), 659

Kinter, L. B., see Mann, W. A., 1231Kisara, K., see Sakurada, T., 205

Kitajima, Y., see Ingi, T., 968Kitamura, K., see Kamouchi, M., 1396

Klauser, R. J., Raake, W., Meinetsberger,E. and Zeiller, P. Antithrombotic and

anticoagulant properties of synthetic

polyanions: Sulfated bis-aldonic acidamides, 8

Knight, P. M., see Rudy, A. C., 1133

Koike, K., see Echizen, H., 953Kong, J.-Q., Taylor, D. A. and Fleming, W.

W. Antagonism of norepinephrine byclonidine in the isolated rat mesen-

teric vascular bed, 653Kowaluk, E. A. and Fung, H.-L. Vascualr

nitric oxide-generating activities fororganic nitrites and organic nitrates

are distinct, 519Kramer, T. H., see Weber, S. J., 1109

Kriegholm, E., see Arner, P., 317Krizsan-Agbas, D., see Bu#{241}ag,R. D., 131Kroemer, H. K., see Turgeon, J., 789Ksander, G., see Levens, N. R., 219Kuwahara, M., see Rego, A., 905

Labetalol, morphine administration, liver

metallothionein, zinc metabolism

(rats), 274Lacerda, A. E., see Rampe, D., 982

fl-Lactam, facilitated transport of cefodi-zime, central nervous system (rats),620

Lactobionic acid amides, synthetic poly-

anions, antithrombotic and antico-

agulant properties (humans), 8

Lain#{234}e, P., see Weissenburger, J., 871

Lale, A., see Herbert, J. M., 44

Lam, S. C. T., Dieter, J. P., Strebel, L. C.,Taylor, T. M., Muscolino, G., Fein-

berg, H. and Le Breton, G. C. Rapiddissociation of platelet-rich fibrin

clots in vitro by a combination of

plasminagen activators and anti-platelet agents, 1371

Lamb, R. J., Preston, K. L., Schindler, C.W., Meisch, R. A., Davis, F., Katz, J.L., Henningfield, J. E. and Goldberg,

S. R. The reinforcing and subjectiveeffects of morphine in post-addicts:

A dose-response study, 1165

Lambert, L. E., see French, J. F., 260

Lanoir, J., see Boulenguez, P., 1360

Laplace, M. C., see Herbert, J. M., 44

Lautt, W. W., see D’Almeida, M. S., 118Lawrence, M. S., see Elsworth, J. D., 595Lazzara, R., see Patterson, E., 558Le Breton, G. C., see Lam, S. C. T., 1371Lechat, P., see Starec, M., 745

Lee, E. H. Y., see Hu, S. C., 1379Lee, V. H. L., see Ashton, P., 719Leedham, J. A., Bennett, L. E., Taylor, D.

A. and Fleming W. W. Involvementof Mu, Delta and Kappa receptors in

morphine-induced tolerance in theguinea pig myenteric plexus, 295

Leedham, J. A., see Taylor, D. A., 1084

Le Fur, G., see Herbert, J. M., 44

Leighton, H. J., see James, M. K., 712Lemakalim, hyperpolarization of denerv-

ated skeletal muscle, antagonism, gli-benclamide and tolbutamide (mice),932

Lemos, J. R., see Wang, X., 705Lenz, D. E., see Broomfield, C. A., 633

Leon, A., see Skaper, S. D., 452Lespy, L., see Herbert, J. M., 44

Leukocytes, monomorphic arylamine N-acetyltransferase expression (hu-

mans), 1241

Leukotriene B4, specific binding sites, brainmembranes (guinea pigs), 1035

Levens, N. R., C#{243}te,D. and Ksander, G.Inhibition of thromboxane synthe-

tase potentiates the antihypertensiveaction of an angiotensin-convertingenzyme inhibitor by a prostaglandin-dependent but kinin-independent

mechanism, 219

Levobunolol, location of penetration and

metabolic barriers, corneal epithe-hum (rabbits), 719

Levy, A. D., Li, Q., Kerr, J. E., Rittenhouse,P. A., Milonas, G., Cabrera, T. M.,Battaglia, G., Sanz, M. C. A. and Van

De Kar, L. D. Cocaine-induced ele-

vation of plasma adrenocorticotropinhormone and corticosterone is me-

diated by serotonergic neurons, 495Lewis, M. H., see Elsworth, J. D., 595

Li, Q., see Levy, A. D., 495Lidocaine

arrhythmogenic activities, atrioventricu-

lar block (dogs), 871

1416 Index Vol. 259

rate-dependent effects, His-Purkinje con-

duction, neonatal heart (dogs), 535

Ligands

-binding properties, tachykinin receptors(rats), 968

cardiovascular effects of adenosine A2 ag-

onists (rats), 1203

heterogeneity of NMDA receptor iono-

phore complex, brain (rats), 86

sigma compounds derived from phency-

clidine (guinea pigs), 543

sigma receptor, multiple mechanisms, tailartery contractile responses (rats), 22

Linnik, M. D., Butler, B. T., Gaddis, R. R.

and Ahmed, N. K. Analysis of sero-tonergic mechanisms underlying

benzamide-induced gastroprokinesis,

501Lipid peroxidation, inhibition of binding of

PN200-i 10 to membranes, ascorbate,

brain and heart (rats), 337Liss, R., see Fischman, A. J., 1351

Liu, F.-Y., see Cogan, M. G., 687

Liverarylamine carcinogen N-acetyltransferase

isozymes, tumor target organ cytosols

(hamsters), 699

hepatic vessels, role of endothelium, vas-oactive agents (dogs), 71

human hepatitis anti-liver kidney micro-

somes autoantibodies (rats), 1328

metallothionein, zinc metabolism, mor-

phine administration (rats), 274protection from hepatic injury, lung

NADPH-cytochrome C-reductase,

polyriboinosinic acid-polyribocyti-

dilic acid (rats), 1059

pyridine effects, P45011E1, IIB and IVB

(rabbits), 470

Livni, E., see Fischman, A. J., 1351LLC-PK1 cells, cyclic GMP levels, forma-

tion, endothelium-derived relaxing

factor-like substance (pigs), 1102

Locomotor activity

central nervous system effects, acetate,ethanol (rats, mice), 403

development oftolerance to nicotine, gen-

otype influences (mice), 392Locus ceruleus, substantia nigra and, neu-

rotoxic effects, 1-methyl-4-phenyl-i,2,3,6-tetrahydropyridine (mice), 1379

Long, J. P., see Park, K. H., 1221Lonigro, A. J., see Joshi, S. N., 71Lopez, M. G., Abad, F., Sancho, C., de Pas-

cual, R., Borges, R., Maroto, R.,

Dixon, W. and Garcia, A. G. Mem-brane-mediated effects of the steroid

i7-a-estradiol on adrenal cat-

echolamine release, 279

Lorenzini, P., see d’Amore, A., 1308Lung

endothelial aminopeptidase P activity,

species variation (cattle, humans,

rats, rabbits, cats, minipigs), 1301identification of alpha-2 adrenoceptor

subtypes, alpha-2 adrenoceptor sub-

types, NCB2O cells (guinea pigs),1124

membranes, substance P binding, high-affinity NK-i receptors (guinea pigs),

146

NADPH-cytochrome C-reductase, poly-

riboinosinic acid-polyribocytidilic

acid, protection from hepatic injury(rats), 1059

oxygen-induced damage in newborns

(rats), 444perfusion model, dopamine clearance

(dogs), 1271

pharmacokinetics and metabolism, nilu-

tamide (rats), 1247Lupinetti, M., see Fitzgerald, G. A., 1043Luthin, D. R. and Cline, W. H. Evidence for

enhanced inhibitory modulation bycyclooxygenase products of noradre-

nergic neurotransmission in the mes-enteric vasculature of young sponta-

neously hypertensive rats, 1174Lymphatics, mesenteric, beta adrenocep-

tors, smooth muscle relaxation, 365Lys-des-Ar�-bradykinin, hypotensive ef-

fects, metabolically protected ago-fists, B1 receptors and kinins (rab-

bits), 997

Lysergic acid diethylamide, discriminative-

stimulus effects, serotonin bindingsites, quipazine and l-5-hydroxytryp-tophan (pigeons), 772

Lysosomes, up-regulation of sigma opioidreceptors, neuroblastoma hybridcells, 302

MacDonald, E., Scheinin, M., Scheinin, H.and Virtanen, R. Comparison of thebehavioral and neurochemical effectsof the two optical enantiomers of

medetomidine, a selective Alpha-2-adrenoceptor agonist, 848

Macleod, R., see Nattel, S., 939Maffrand, J. P., see Herbert, J. M., 44

Maggi, C. A., see Geppetti, P., 759

Magnesium, intravenous, ventricular ar-

rhythmias, acute myocardial infarc-

tion (dogs), 939

Mailman, R. B., see Elsworth, J. D., 595

Maiorino, R. M., Dart, R. C., Carter, D. E.

and Aposhian, H. V. Determinationand metabolism of dithiol chelatingagents. XII. Metabolism and phar-macokinetics of sodium 2,3-dimer-captopropane-i-sulfonate in hu-mans, 808

Maj, R., see Buonamici, M., 345Makujina, S. R., see Sabouni, M. H., 508

Mammalian cells, ligand-binding proper-

ties, tachykinin receptors (rats), 968

Man In’T Veld, A. J., see Boomsma, F., 551Mann, W. A., Welzel, G. E., Goldstein, R.

S., Sozio, R. S., Cyronak, M. J., Kao,J. and Kinter, L. B. Characterization

of the renal effects and renal elimi-

nation of sulotroban in the dog, 1231Manome, Y., see Sakurada, T., 205Mansour, H., see Coutant-Perronne, V.,

1059

Mansuy, D., see Pons, C., 1328Mantegani, S., see Buonamici, M., 345Mantegani, S., see Carfagna, N., 356

Manzini, S., see Geppetti, P., 759Marceau, F., see Drapeau, G., 997Marks, M. J., Campbell, S. M., Romm, E.

and Collins, A. C. Genotype influ-ences the development of tolerance

to nicotine in the mouse, 392

Markus, R. P., see Carneiro, R. C. G., 614Maroto, R., see Lopez, M. G., 279Marquetty, C., see Coutant-Perronne, V.,

1059

Martin, P., see Zini, R., 414Maruyama, M., see Auchampach, J. A., 961Massamiri, T. and Duckles, S. P. Sigma

receptor ligands inhibit rat tail artery

contractile responses by multiplemechanisms, 22

Massotti, M., see d’Amore, A., 1308Mast cells, environmental tobacco smoke,

intranasal capsaicin, symptoms and

mediator release (humans), 1323Matsunaga, K. and Furchgott, R. F. Re-

sponses of rabbit aorta to nitric oxideand superoxide generated by ultravi-olet irradiation of solutions contain-ing inorganic nitrite, 1140

Matsushita, H., Suzuki, H., Sugiyama, Y.,Sawada, Y., Iga, T., Kawaguchi, Y.and Hanano, M. Facilitated trans-port ofcefodizime into the rat centralnervous system, 620

Maxwell, D. M., see Broomfield, C. A., 633Mayer, E., see Cardoso, P. F. G., 1271Mays, D. C., Dixon, K. F., Balboa, A., Paw-

luk, L. J., Bauer, M. R., Nawoot, S.and Gerber, N. A nonprimate animalmodel applicable to zidovudine phar.macokinetics in humans: Inhibitionof glucuronidation and renal excre-tion of zidovudine pharmacokineticsin humans: Inhibition of glucuroni-dation and renal excretion of zido-vudine by probenecid in rats, 1261

Maze, M., see Schwinn, D. A., 1147McHale, R. J., see Belcheva, M. M., 302McKinney, M., see Miller, J. H., 601Medeiros, Y. S., see Calixto, J. B., 659Medetomidine, behavioral and neurochem-

ical effects (rats), 848Meinetsberger, E., see Klauser, R. J., 8Meisch, R. A., see Lamb, R. J., 1165

Melatonin, diurnal variation of vas deferens

contraction, presynpatic nicotinic re-ceptors (rats), 614

Membrane potential, nicotine-inducedchanges, tetraphenylphosphoniumaccumulation, cerebral cortical syn-aptosomes (rats), 1118

Memo, M., see Carruba, M. 0., 124Mercury, chelating agents, sodium 2,3-di-

mercaptopropane-1-sulfonate phar-macokinetics (humans), 808

Mesentery, vaseulature, enhanced inhibi-

tory modulation, cycbooxygenaseproducts (rats), 1174

Mestre, M., see Borg, C., 526Metallothionein, liver, zinc metabolism,

morphine administration (rats), 274Metaphit, dopaminergic neurotransmission,

striatal slices (rats), 1188

Methamphetamine, responses of extrapyr-

amidal and limbic neuropeptides,fenfluramine administration (rats),

1197

N-Methyl-D-aspartate, inhibition of re-sponses, 1,10-bis(guanidino)decane(rats), 626

3-Methylcholanthrene, oxygen-inducedlung damage in newborns (rats), 444

3,4-Methylenedioxymethamphetamine, -in-duced dopamine release, microdi-alysis studies (rats), 820

(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro- 1H-benzimidazolhy-

drochloride, see YMO6O

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyri-

dine

D1 and D2 agonists and antagonists, dys-

kinesia, L-dopa (monkeys), 409

1991 Index 1417

neurotoxic effects, substantia nigra, locusceruleus (mice), 1379

Methylprednisolone, pharmacokinetics, ef-fect of ketoconazole, receptor/gene-

mediated pharmacodynamics (rats),

8265-Methylurapidil, reduction of cardiac out-

ward currents, alpha- 1 adrenoceptor

stimulation (rats), 783

Methylxanthine, treatment of smooth mus-

cle cells, modulation, adenylate cy-clase responsiveness, 925

Metoclopramide, benzamide-induced gas-troprokinesis, serotonergic mecha-

nisms (rats), 501Metoprolol, beta adrenoceptors, smooth

muscle relaxation, bovine mesentericlymphatics, 365

Mexiletine, disposition, influence of debri-

soquine phenotype, quinidine (hu-

mans), 789

Microtubule, -taxol interactions, effect of

alkaline pH, 855Milburn, M. R., see Purdy, R. E., 1316

Miller, J. H., Gibson, V. A. and McKinney,

M. Binding of [3H]AF-DX 384 tocloned and native muscarinic recep-

tors, 601

Miller, L. S., see Hem, D. W., 699

Miller, M. A., see Cribb, A. E., 1241

Miller, R. J., see Bleakman, D., 430Milonas, G., see Levy, A. D., 495Minamitake, Y., see Ingi, T., 968

Minhas, K., see Carmichael, F. J., 403Miosis, reinforcing and subjective effects of

morphine, post-addicts, 1165

Mironneau, C., see Rakotoarisoa, L., 164Mironneau, J., see Rakotoarisoa, L., 164

Miura, K., see Yamashita, Y., 1256Miyata, K., Kamato, T., Nishida, A., Ito,

H., Katsuyama, Y., Iwai, A., Yuki,

H., Yamano, M., Tsutsumi, R., Ohta,M., Takeda, M. and Honda, K. Phar-macologic profile of (R)-5-[(1-methyl-3indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-ben zimidazol Hydro-

chloride (YMO6O), a potent and se-

lective 5-hydroxytryptamine3 recep-

tor antagonist and its enantiomer inthe isolated tissue, 15

Miyata, K., Kamato, T., Yamano, M., Nish-ida, A., Ito, H., Katsuyama, Y., Yuki,

H., Tsutsumi, R., Ohta, M., Takeda,

M. and Honda, K. Serotonin (5-HT)3

receptor blocking activities ofYMO6O, a novel 4,5,6,7-tetrahydro-benzimidazole derivative, and its en-antiomer in anesthetized rats, 815

MK-801

anticonvulsant activity, 5-aminocar-

bonyl-10,11-dihydro-5H-dibenz[a,d}

cyclohepten -5,10-imine (mice, rats),30

heterogeneity of NMDA receptor iono-phore complex, brain (rats), 86

Moerike, K., see Turgeon, J., 789

Molinoff, P. B., see Collins, K. A., 337

Molinoff, P. B., see Ivins, K. J., 423Mondot, S., see Borg, C., 526Monn, J. A., see Rogawski, M. A., 30Monn, J. A., see Sacaan, A. I., 1366

Monoclonal antibodies, selective transport

of anti-transferrin receptor antibody,blood brain barrier (mice, rats, hu-

mans, cattle), 66

NG�Monomethyl L-arginine

effects of guanidino compounds (rats),

490

-induced pressor response, developmental

and established stages, sponta-

neously hypertensive rats, 52

Mono-N-dealkyldisopyramide, stereoselec-

tive disposition and metabolism, di-sopyramide, pediatric patients, 953

Monosialogangliosides, reduction of deathof hippocampal pyramidal neurons,

activation NMDA receptors (rats),

452Morel, A., see Boulenguez, P., 1360

Mori, T., see Kageyama, M., 1019Morin, D., see Zini, R., 414Moromizato, H., see Noguchi, K., 732

Morphinecontinuous naloxone infusion, increased

analgesic potency, mu agonists (rats),

582immune status and survival, Friend virus

(mice), 745

-induced tolerance in myenteric plexus,

mu/delta/kappa receptors (guineapigs), 295

intracerebroventricular release, adeno-

sine and adenosine 3’,S’-cyclic mon-

ophosphate, spinal cord (rats), 1013

lack of spinal antianalgesic activity, dy-

norphins (mice), 1073

liver metallothionein and zinc metabo-

lism (rats), 274

reinforcing and subjective effects, post-

addicts, 1165

Morrison, K. J. and Vanhoutte, P. M. In-

hibition of airway smooth muscle

tone by a phorbol ester in the guinea

pgi trachea: Role of epithelium and

receptor reserve of the contractile

agent, 198

Mott#{233}, G., see Weissenburger, J., 871

Mucus, production, pharmacological profile,

UP 5145-52 (rats), 190Murad, F., see Ishii, K., 1102

Murakami, M., see Ren, L.-M., 38

Murphy, T. J., see Blaxall, H. S., 323Muscle

gastrocnemius, intra-arterial epinephrine,

energy metabolism (rabbits), 458

longitudinalcalcitonin gene-related peptide, ileum

(guinea pigs), 947

morphine tolerance, GABA and myen-

teric plexus preparation (guinea

pigs), 1094

Muscle, skeletal, denervated, hyperpolari-zation by lemakalim, antagonism by

glibenclamide and tolbutamide(mice), 932

Muscle, smooth

airway, inhibition by phorbol ester, tra-

chea (guinea pigs), 198antagonism of norepinephrine, clonidine,

mesenteric vascular bed (rats), 653

ATP-evoked ATP release system (guinea

pigs), 513bronchial, membrane potential, depolar-

izing agents (dogs), 110

coronary artery, adenosine receptor-me-diated relaxation, inhibition of aden-

ylate cyclase (pigs), 508

detrusor, mechanical activity, potassium

channel blockers and cromakalim(guinea pigs), 1158

gastric myocytes, cisapride action, mus-

carinic receptors (guinea pigs), 1294

methylxanthine treatment, modulation,adenylate cyclase responsiveness, 925

portal vein, ionic currents, vasodilating

actions of E4080 (rabbits), 1396

relaxation, beta adrenoceptors, bovine

mesenteric lymphatics, 365

specific inhibitor of protein kinase C,

staurosporine, coronary arteries

(pig), 1019

spontaneous motility and tonus, charyb-

dotoxin and iberiotoxin, smooth

muscle tissues (guinea pigs), 439

vascular

actions of TA 3090, femoral and coro-

nary arteries (dogs), 639

guanine nucleotide-binding proteins,

desmethoxyverapamil binding (rats),

164inhibition ofproliferation, HA1077, 738

interleukin 1�3-induced depression, ni-

tric oxide synthase inhibitors (rats),

260Muscolino, G., see Lam, S. C. T., 1371

Mustafa, S. J., see Sabouni, M. H., 508

Myenteric plexuscalcitonin gene-related peptide, ileum

(guinea pigs), 947morphine-induced tolerance, mu/delta/

kappa receptors (guinea pigs), 295morphine-tolerant longitudinal muscle,

GABA effects (guinea pigs), 1094

Myers, A. C. and Undem, B. J. Functional

interactions between capsaicin-sen-

sitive and cholinergic nerves in the

guinea pig bronchus, 104

Myocardial infarction

acute, intravenous magnesium, ventricu-lar arrhythmias (dogs), 939

reduction of size, aprikalim, absence of

hemodynamic changes (dogs), 961

Myocardial ischemiaanti-ischemic actions of mechanistically

diverse agents, potassium channel

blockade (rats), 97intracoronary procaterol, beta-2 adreno-

ceptor stimulation (dogs), 732

Myocytes, gastric, contraction, cisapride ac-

tion on muscarinic receptors (guinea

pigs), 1294

NADPH-cytochrome C-reductase, lung, p0-

lyriboinosinic acid-polyribocytidilic

acid, protection from hepatic injury

(rats), 1059

Nagao, T., see Yamazaki, J., 52

Nakagawa, M., see Shirayama, T., 884

Nakahiro, M., Arakawa, 0. and Narahashi,

T. Modulation of -y-aminobutyric

acid receptor-channel complex by al-cohols, 235

Nakamura, H., see Echizen, H., 953

Nakanishi, S., see Ingi, T., 968

Nakazawa, H., see Ohrui, T., 371

Nakazawa, K., see Ohara-Imaizumi, M., 484

Naloxonecontinuous infusion, increased analgesic

potency, mu agonists (rats), 582dose-dependent increase in total power,

delta wave activity in EEG (rats), 464Naltrexone, up-regulation of sigma opioid

receptors, neuroblastoma hybridcells, 302

Naltrindole, selective antagonism, cyclic[D-

1418 Index Vol. 259

penicillamine2-D-penicillamine5] en-

kephalin (rats), 725

Narahashi, T., see Nakahiro, M., 235Narita, M., see Ren, L.-M., 38

Nash, J. F. and Brodkin, J. Microdialysis

studies on 3,4-methylenedioxyme-

thamphetamine-induced dopamine

release: Effect of dopamine uptake

inhibitors, 820

Nattel, S., Turmel, N., Macleod, R. andSolymoss, B. C. Actions of intrave-

nous magnesium on ventricular ar-

rythmias caused by acute myocardial

infarction, 939

Nawoot, S., see Mays, D. C., 1261

Neonate, heart, rate-dependent effects, li-

docaine (dogs), 535Nerve

cholinergic, capsaicin sensitivity, bron-

chus (guinea pigs), 104

sympathetic

activation, chronic insulin treatment

(rats), 131

constrictor responses, glucagon phar-macodynamics (cats), 118

Nerve terminals, cerebrocortex, GABAB re-

ceptors, inhibition of somatostatin

release (rats), 1153Neuroblastoma

identification of alpha-2 adrenoceptors

subtypes, SK&F 104078 and SK&F

104856, NCB2O cells and guinea pig

lung, 1124

mouse, rat glioma hybrid cell line, sigma-like binding sites, 479

Neuroblastoma hybrid cells, up-regulation,

sigma opioid receptors, 302Neurohypophysial terminals, inhibition of

calcium currents and peptide release,

ethanol (rats), 705

Neurokinin, substance P binding, high-af-

finity NK-i receptors, lung mem-

branes (guinea pigs), 146

Neurokinin A, capsaicin-sensitive and cho-

linergic nerves, functional interac-

tions, bronchus (guinea pigs), 104

Neurons

nigral, dopaminergic neurotransmission,

deprenyl (rats), 841

serotonergic, cocaine-induced elevation,

plasma adrenocorticotropin hormone

(rats), 495

Neuropeptides

extrapyramidal and limbic, fenfluramine

administration (rats), 1197

release from capsaicin-sensitive sensory

nerve fibers, arachidonic acid and

bradykinin, heart (guinea pigs), 759

Neuropeptide Y, differential inhibition,

chronotropic and inotropic re-

sponses, sympathetic and parasym-

pathetic stimulation (dogs), 38

Neurotransmission

cholinergic, action of potassium channel

openers, sulfonylurea receptors

(guinea pigs), 566

cocaine and tracheal epithelial function

(swine), 241

noradrenergic, enhanced inhibitory mod-

ulation, cyclooxygenase products(rats), 1174

vascular sympathetic, age-related

changes, norepinephrine (rats), 176

Neurotransmitters, sensitivity of cerebellar

Purkinje neurons, genetically epilep-

tic rats, 1008

NG1O8-15, sigma-like binding sites, 479Nichols, D. E., see Elsworth, J. D., 595

Nicorandil, potassium channel opening,

guanylate cyclase stimulation, vaso-

relaxation (rats), 526Nicotine

development of tolerance, genotype influ-

ences (mice), 392-induced changes in membrane potential,

tetraphenylphosphonium accumula-

tion, cerebral cortical synaptosomes(rats), 1118

Nies, A. S., Tunney, A., Barden, A., Sturm,

M. and Vandongen, R. Release ofplatelet activating factor by the iso-lated kidney is not linked to the pro-duction of prostaglandins, 590

Nifedipine, hypoxic pulmonary vasocon-

striction, vanadate (rats), 666Nikodijevi#{234}, 0., Sarges, R., Daly, J. W. and

Jacobson, K. A. Behavioral effects ofA1- and A2-selective adenosine ago-nists and antagonists: Evidence for

synergism and antagonism, 286

Nilutamide, pharmacokinetics and metabo-

lism in lung (rats), 1247Nioka, S., see Argov, Z., 458Nishida, A., see Miyata, K., 15, 815Nisoli, E., see Carruba, M. 0., 124Nissbrandt, H., see Engberg, G., 841

Nitrates, organic, distinction from organic

nitrites, nitric oxide-generating ac-tivities, 519

Nitric oxide

effects of endothelin-3, renal function

(dogs), 1256effects of guanidino compounds, N’-mon-

omethyl L-arginine (rats), 490

formation of endothelium-derived relax-

ing factor-like substance, endothelin,increased cyclic GMP levels (pigs),

1102

-generating activities, organic nitrites, or-

ganic nitrates, 519NG�monomethyl�L�arginine�induced

pressor response, developmental and

established stages, spontaneously hy-pertensive rats, 52

responses of aorta, ultraviolet irradiationof solutions (rabbits), 1140

Nitric oxide synthase

endothelium-derived relaxing factor, bo-vine cerebellum, high and low oxygen

tensions, 310

inhibitors, interleukin 1�3-induced depres-

sion, vascular smooth muscle (rats),

260

Nitrobenzylthioguanosine, -sensitive and -

resistant nucleoside transport, Ehr-lich ascites tumor cells, 799

Nitroglycerin, vasorelaxation, nicorandil,

potassium channel opening (rats),

526Noguchi, K., Ojiri, Y., Chibana, T., Morom-

izato, H. and Sakanashi, M. Cardiaceffects of Beta-2 adrenoceptor stim-

ulation with intracoronary procaterolin the absence and presence of re-

gional myocardial ischemia in dogs,732

Noradrenaline, differential inhibition ofneuropeptide Y, chronotropic and in-otropic responses, atrium (dogs), 38

Nordmann, J. J., see Wang, X., 705Norepinephrine

age-related changes, vascular sympathetic

neurotransmission, kidney (rats), 176antagonism by clonidine, mesenteric vas-

cular bed (rats), 653enhanced inhibitory modulation, cycboox-

ygenase products, noradrenergic neu-rotransmission (rats), 1174

-induced constrictor responses, glucagonpharmacodynamics (cats), 118

mechanism of positive inotropy, low con-

centrations, strophanthidin (sheep),

182

oxidation products, binding to plasma

proteins, 551

reduced G protein function, desensitizedaorta (rats), 255

release and cocaine effects, developmental

shift from local to central control,cardiac-sympathetic axis (rats), 976

sensitivity of cerebellar Purkinje neurons,genetically epileptic rats, 1008

Novak, R. F., see Kim, S. G., 470Nuclear magnetic resonance, intra-arterial

epinephrine, energy metabolism, ex-ercising gastrocnemius muscle (rab-

bits), 458

Nucleoside, transport, nitrobenzylthiogu-anosine, Ehrlich ascites tumor cells,799

Nucleotides, functional studies in subman-dibular duct cell line, salivary glandreceptor subtype, 1344

Nye, H. E., Seidler, F. J. and Slotkin, T. A.Developmental shift from local to

central control of norepinephrine re-

lease in the cardiac-sympathetic axis:Effects of cocaine and related drugs,

976

Obama, T., see Ohara-Imaizumi, M., 484Ochiai, K., see Echizen, H., 953O’Donnell, M., Crowley, H. J., Yaremko, B.,

O’Neill, N. and Welton, A. F. Phar-macologic actions of Ro 24-5913, anovel antagonist of leukotriene D4,751

O’Donnell, M., see Crowley, H. J., 78Ogata, H., see Echizen, H., 953Ogawa, S., see Katsuragi, T., 513Ogita, K., see Yoneda, Y., 86Ohara-Imaizumi, M., Nakazawa, K., Ob-

ama, T., Fujimori, K., Takanaka, A.and Inoue, K. Inhibitory action ofperipheral-type benzodiazepines on

dopamine release from PC!2 pheo-chromocytoma cells, 484

Ohba, M., see Sakurada, T., 205Ohhashi, T., see Ikomi, F., 365Ohkawara, Y., see Ohrui, T., 371

Ohrui, T., Sekizawa, K., Yamauchi, K.,Ohkawara, Y., Nakazawa, H., Ai-kawa, T., Sasaki, H. and Takishima,T. Chemical oxidant potentiates elec-trically and acetylcholine-inducedcontraction in rat trachea: Possible

involvement of cholinesterase inhi-bition, 371

Ohta, M., see Miyata, K., 15, 815Oikari, A., see Pritchard, J. B., 156Ojiri, Y., see Noguchi, K., 732

Okabe, K., see Kamouchi, M., 1396Okumura, M., see Yamashita, Y., 1256Olfactory bulb, muscarinic stimulation,

1991 Index 1419

adenylate cyclase activity (rats), 673,680

Olianas, M. C. and Onali, P. Muscarinic

stimulation of adenylate cyclase ac-tivity ofrat olfactory bulb. I. Analysisof agonist sensitivity, 673

Olianas, M. C. and Onali, P. Muscarinicstimulation of adenlylate cyclase ac-tivity of rat olfactory bulb. II. Char-acterization of the antagonist sensi-tivity and comparison with musca-

rinic inhibitions of the enzyme instriatum and heart, 680

Onali, P., see Olianas, M. C., 673, 680

O’Neill, N., see O’Donnell, M., 751Opiates

opioid peptides and, antinociceptive ac-tion, area tempestas (rats), 1308

reinforcing and subjective effects of mor-

phine, post-addicts, 1165Opioids, distribution and analgesia, [3H][D-

Pen2,D-Pen5]enkephalin (mice), 1109

Orfanos, S. E., see Chen, X., 1301Organophosphorus, poisoning, protection

by butyrylcholinesterase, nonhuman

primates, 633Orrego, H., see Carmichael, F. J., 403Ortiz, L., see Banks, W. A., 988

Owyang, C., see Hasler, W. L., 1294

Oxygenhigh and low tensions, endothelium-de-

rived relaxing factor/nitric oxide syn-thase, 310

-induced lung damage, newborns (rats),

444

Oxymetazoline, imidazoline desensitization,epinephrine responses, vas deferens

(rats), 1182

Page, S. 0., see Schwinn, D. A., 1147

Pardridge, W. M., Buciak, J. L. and Friden,

P. M. Selective transport of an anti-transferrin receptor antibody

through the blood-brain barrier in

vivo, 66

Parish, D. W., see Su, T.-P., 543

Park, C. S., Honeyman, T. W., Ha, S. K.,Choi, H. K., Chung, C. L. and Hong,

C. D. Mechanisms of ionophore-in-duced stimulation of renin secretion

with special regerence to a chemios-

motic hypothesis, 211Park, K. H., Long, J. P. and Cannon, J. G.

Evaluation ofthe central and periph-

eral components for induction of pos-

tural hypotension by guanethidine,clonidine, dopamine2 receptor ago-

fists and 5-hydroxytryptamine1A re-

ceptor agonists, 1, 221Parkinson, A., see Thibeault, D. W., 444Parkinson’s disease, deprenyl, locomotor ac-

tivity, dopaminergic neurotransmis-

sion (rats), 841

Paronis, C. A. and Holtzman, S. G. In-creased analgesic potency of Mu ag-

onists after continuous naloxone in-

fusion in rats, 582

Patterson, E., Scherlag, B. J., Berlin, K. D.and Lazzara, R. Electrophysiological

actions of BRB-I-28 in canine myo-cardial tissues, 558

Patterson, G. A., see Cardoso, P. F. G., 1271Pawluk, L. J., see Mays, D. C., 1261

PC12 cells, inhibitory action of peripheral-type benzodiazepines, dopamine re-

lease, 484

P11 cells, desensitization and down-regula-tion, 5-HT2 receptors, 423

PD123177, DUP 753 and, inhibitory po-

tency, proximal nephron and renaltransport (rats), 687

Penin, E., see Weissenburger, J., 871Pentazocine, immune status and survival,

opiate and cocaine treatment, Friendvirus (mice), 745

Peptide, release, inhibition by ethanol, neu-

rohypophysial terminals (rats), 705

Pergolide, anti-inflammatory activity (rats),169

Perkins, W. E., Burton, E. G., Tsai, B. S.,

Collins, P. W., Casler, J. J., Gasiecki,

A. F., Bauer, R. F., Jones, P. H. andGaginella, T. S. SC-46275: A potent,

long-acting gastric antisecretory

prostaglandin with low oral bioavail-

ability in the dog, 1004

Perrier, D., see Cardoso, P. F. G., 1271

Pertussis toxin

injection into AlO dopamine region, sen-sitization, psychostimulants andstress (rats), 916

-insensitive biphasic response, bradyki-fin, circular muscle of ileum (guinea

pigs), 659

Pessayre, D., see Deschamps, D., 894

pH, alkaline, taxol-microtubule interac-tions, 855

Phencyclidine, sigma compounds, PRE-084

(guinea pigs), 543Phillips, E. T., see Helke, C. J., 1335

Philpot, R. M., see Kim, S. G., 470Phorbol 12,13-dibutyrate, specific inhibitor

of protein kinase C, staurosporine,

coronary arteries (pig), 1019Phorbol ester, inhibition of airway smooth

muscle tone, trachea (guinea pigs),

198

Phorbol myristate acetate, hypoxic pulmo-

nary vasoconstriction, vanadate

(rats), 666

Phosphoinositide hydrolysisactivation of alpha- 1 adrenoceptors, dex-

medetomidine (rats), 1147

desensitization and down-regulation, 5-HT2 receptors, P11 cells, 423

metabotropic excitatory amino acid re-

ceptor agonist, intrastriatal injection,

contralateral turning (rats), 1366Pickles, R. J., see Roberts, M., 1050Pickoff, A. S., see Dise, T. L., 535Pineal gland, diurnal variation of vas def-

erens contraction, presynpatic nico-

tinic receptors (rats), 614

Pizzi, M., see Carruba, M. 0., 124

Plasma, protein binding, oxidation prod-

ucts, norepinephrine, 551

Plasminogen activators, antiplatelet agents

and, rapid dissociation, platelet-rich

fibrin clots (humans), 1371

Platelet-activating factorinduction of nonspecific desensitization,

bronchodilators (guinea pigs), 1

pharmacology of Ro 24-4736 (guinea pigs,

dogs, humans), 78receptor antagonist SR 27417 (rabbits,

humans), 44

release by kidney, no link to prostaglan-

din production (rats), 590

Plateletsdepletion, C5a-induced bronchoconstric-

tion, inhibition by H1 antagonist

(guinea pigs), 1213

homologous downregulation, thrombox-ane A2 receptors, K562 cells, 228

presystemic acetylation, aspirin (hu-

mans), 1043

-rich fibrin clots, dissociation, plasmino-gen activators and antiplatelet agents

(humans), 1371

Plotkin, S. R., see Banks, W. A., 988

PN200-110, inhibition of binding to mem-

branes, brain and heart, ascorbateand lipid peroxidation (rats), 337

Pocidalo, J.-J., see Coutant-Perronne, V.,1059

Pocidalo, J.-J., see Starec, M., 745Poirier, J. M., see Weissenburger, J., 871

Polyanions, synthetic, antithrombotic andanticoagulant properties (humans), 8

Polymorphism, arylamine carcinogen N-acetyltransferase isozymes, tumor

target organ cytosols (hamsters), 699

Polyriboinosinic acid, -polyribocytidilic

acid, lung NADPH-cytochrome C-re-

ductase, protection from hepatic in-

jury (rats), 1059

Pons, C., Dansette, P. M., Amar, C., Jaouen,M., Wolf, C. R., Gregeois, J., Horn-

berg, J. C. and Mansuy, D. Detectionof human hepatitis anti-liver kideny

microsomes (LKM2) autoantibodieson rat liver sections is predominantly

due to reactivity with rat liver P-450

liCli, 1328

Pop, R. D., see Cardoso, P. F. G., 1271

Portal vein, smooth muscle cells, ionic cur-

rents, vasodilating actions of E4080(rabbits), 1396

Positron emission tomography, pharmaco-

kinetics of ‘8F-labeled fluconazole,

candidal infections (rats, rabbits),

1351

Potassium channelblockade, anti-ischemic actions, mechan-

istically diverse agents (rats), 97

blockers and cromakalim, mechanical ac-tivity, detrusor smooth muscle

(guinea pigs), 1158

bronchial smooth muscle membrane po-tential, depolarizing agents (dogs),110

hyperpolarization of denervated skeletal

muscle, lemakalim, antagonism by

glibenclamide and tolbutamide(mice), 932

openersaprikalim, reduction of infarct size

(dogs), 961

nicorandil, vasorelaxation (rats), 526sulfonylurea receptors, small intestine

(guinea pigs), 566Pounds, J. J., see Hillard, C. J., 1118Prazosin

alpha- 1 adrenergic receptors, renal med-

ullary collecting duct cells (rabbits),

1081behavioral and neurochemical effects,

medetomidine (rats), 848

PRE-084, sigma compounds derived fromphencyclidine (guinea pigs), 543

Preservative, location of penetration and

metabolic barriers, levobunolol, cor-neal epithelium (rabbits), 719

Preston, K. L., see Lamb, R. J., 1165

Pritchard, J. B., Walden, R. and Oikari, A.

1420 Index Vol. 259

Dehydroabietic acid, a major anionic

contaminant of pulp mill effluent, re-

duces both active p-aminohippurate

transport and passive membrane

permeability in isolated renal mem-branes, 156

Probenecid, nonprimate animal model, zi-

dovudine pharmacokinetics in hu-

mans, 1261

Procaterol, intracoronary, beta-2 adreno-

ceptor stimulation, myocardial ische-

mia (dogs), 732

Propranolol, arrhythmogenic activities,atrioventricular block (dogs), 871

Prostaglandinenhanced inhibitory modulation, cycloox-

ygenase products, noradrenergic neu-

rotransmission (rats), 1174

hypotensive effects of lys-des-arg9-brady-

kinin, metabolically protected ago-

nists, B1 receptors for kinins (rab-

bits), 997

inhibition of thromboxane synthetase,

antihypertensive action, angiotensin-

converting enzyme (rats), 219pertussis toxin-insensitive biphasic re-

sponse, bradykinin, circular muscleof ileum (guinea pigs), 659

production, release of platelet-activatingfactor, kidney (rats), 590

SC-46275, low oral bioavailability (dogs),

1004

Prostaglandin E1 , plasminogen activatorsand antiplatelet agents, rapid disso-ciation, platelet-rich fibrin clots (hu-

mans), 1371

Protein kinase Chypoxic pulmonary vasoconstriction, van-

adate (rats), 666inhibition of airway smooth muscle tone,

phorbol ester, trachea (guinea pigs),

198specific inhibitor, staurosporine, coronary

arteries (pig), 1019Proteins, plasma, binding, oxidation prod-

ucts of norepinephrine, 551

Proud, D., see Bascom, R., 1323

Psychostimulants, stress and, sensitization,

pertussis toxin injection in AlO do-pamine region (rats), 916

Puech, A. J., see Zini, R., 414

Purdy, R. E. and Milburn, M. R. Evidenceagainst serotonin-induced endothe-

hum-dependent relaxation in bovinecoronary artery, 1316

Purkinje fibersmechanism of positive inotropy, low con-

centrations, strophanthidin (sheep),

182

neurons, sensitivity to neurotransimtters,

genetically epileptic rats, 1008Puskas, J., see Cardoso, P. F. G., 1271Pyridine, effects on P45011E1, IIB and IVB

expression, liver (rabbits), 470Pyrilamine, C5a-induced bronchoconstric-

tion, inhibition by H1 antagonist

(guinea pigs), 1213

Quinidine

arrhythmogenic activities, atrioventricu-

lar block (dogs), 871influence of debrisoquine phenotype,

mexiletine disposition (humans), 789

Quinpirole, monoaminergic receptors, hy-

pothalamic nuclei, feeding behavior

(rats), 124

Quipazine, l-5-hydroxytryptophan and, dis-criminative-stimulus effects, sero-

tonin binding sites (pigeons), 772

Raake, W., see Klauser, R. J., 8Radiolabeling, pharmacokientics of ‘8F-la-

beled fluconazole, candidal infections(rats, rabbits), 1351

Rady, J. J., Fujimoto, J. M. and Tseng, L.F. Dynorphins other than dynorphin

A(1-17) lack spinal antianalgesic ac-tivity but do act on dynorphin A(1-

17) receptors, 1073

Rafferty, M. F., see Drower, E. J., 725Raiteri, M., see Bonanno, G., 1153Rakotoarisoa, L., Mironneau, C., Sayet, I.

and Mironneau, J. Guanine nucleo-tide-binding proteins modulate des-

methoxyverapamil binding to cal-

cium channels in vascular smooth

muscle, 164Rampe, D. and Lacerda, A. E. A new site

for the activation of cardiac calciumchannels defined by the nondihydro-pyridine FPL 641176, 982

Ramwell, P. W., see Rego, A., 905Ramwell, P. W., see Thomas, G., 490Rapoport, H., see Swanson, K. L., 377Rapoport, H., see Wonnacott, S., 387

Rauwolscinealpha-2C adrenoceptors, opossum kidney,

OK cell line, 323identification of alpha-2 adrenoceptor

subtypes, SK&F 104078 and SK&F104856, NCB2O cells and guinea pig

lung, 1124Ravens, U., see Wang, X.-L., 783Ray, C., see Blaxall, H. S., 323Ray, S., see Fischman, A. J., 1351

Receptorsadenosine

methylxanthine treatment, smooth

muscle cells, 925

relaxation in coronary artery, inhibi-tion of adenylate cyclase (pigs), 508

D,L-a-aminO-3-hydrOxy-5-methyl-4-isOX-

azole propionate, presynaptic facili-tation, dopamine release (rats), 692

angiotensin!!

PD123177 and DuP 753, proximalnephron and renal transport (rats),687

pharmacology of DuP 532 (rats), 861anti-transferrin, selective transport

through blood-brain barrier (mice,

rats, humans, cattle), 66B1, kinins, hypotensive effects of lys-des-

arg�-bradykinin (rabbits), 997

benzodiazepine, cocaine, discrete regionsof brain (rats), 574

dopamine, pergolide, anti-inflammatoryactivity (rats), 169

dopamine Dl, regulation, striatal acetyl-

choline release (rats), 1064dopamine D2, induction, postural hypo-

tension (rats), 1221

dopamine D1 and D2dyskinesia, L-dopa (monkeys), 409spontaneous blink rate (monkeys), 595

GABA, channel complex, modulation byalcohols (rats), 235

GABAB, inhibition of somatostatin re-lease, cerebrocortex nerve terminals

(rats), 11535-HT2

desensitization and down-regulation,P11 cells, 423

i-(2,5-dimethoxy-4-iodophenyl)-2-

aminopropane, modification of car-diovascular function (rats), 1027

increased renin secretion and bloodpressure, DOl (rats), 58

5-HT3, blocking activities of YMO6O(rats), 815

5-HT1A, induction, postural hypotension

(rats), 1221

5-HT1�2, agonists, thoracic spinal cord(rats), 1335

5-HT1B and 5-HTLD, pharmacological

characterization, serotonin-O-car-boxymethyl-glyceryl-tyrosinamide

(rats, guinea pigs), 1360leukotriene B4, specific binding sites,

brain membranes (guinea pigs), 1035leukotriene D4, pharmacologic actions, Ro

24-5913 (humans, guinea pigs), 751metabotropic excitatory amino acid, in-

trastriatal injection, contralateralturning (rats), 1366

N-methyl-D-aspartatedeath of hippocampal pyramidal neu-

rons, reduction by monosialoganglio-sides (rats), 452

excitatory amino acids, breathing re-quirements in ventrolateral medulla

(cats), 1388

inhibition of responses, 1,10-

bis(guanidino)decane (rats), 626ionophore complex, brain (rats), 86regulation, striatal acetylcholine re-

lease (rats), 1064

methylprenisolone, effect of ketocona-zole, gene-mediated pharmacody-namics (rats), 826

monoaminergic, hypothalamic nuclei,feeding behavior (rats), 124

muscarinicadenylate cyclase activity, olfactory

bulb (rats), 673, 680

binding of AF-DX 384 (rats), 601

cisapride, contraction of gastric myo-

cytes (guinea pigs), 1294

neurokinin 1, substance P analogs, spinalcord (mice), 205

neurotransmitter, cocaine, tracheal epi-

thelial function (swine), 241

nicotinic, diurnal variation of vas defer-ens contraction, pineal function

(rats), 614

nicotinic acetylcholine, anatoxin analogs,377, 387

NK-1, substance P binding, lung mem-branes (guinea pigs), 146

opioid

activity in isolated tissues (guinea pigs,rats, mice), 712

antinociceptive action, area tempestas

(rats), 1308opioid delta, selective antagonism by nal-

trindole (rats), 725opioid epsilon and kappa, inhibition of

tail-flick response, bremazocine(mice), 330

opioid mu/delta/kappa, morphine-in-duced tolerance, myenteric plexus(guinea pigs), 295

opioid sigmacompounds derived from phencyclidine

(guinea pigs), 543hybrid cell line NG1O8-15, 479

1991 Index 1421

ligands that inhibit artery contractileresponses (rats), 22

up-regulation, neuroblastoma hybrid

cells, 302

platelet-activating factor

antagonist, SR 27417 (rabbits, hu-

mans), 44

pharmacology, Ro 24-4736 (guinea pigs,

dogs, humans), 78

reserve, inhibition of airway smooth mus-

cle tone, phorbol ester (guinea pigs),

198

salivary gland, subtype, nucleotides, 1344

sulfonylurea, action of potassium channel

openers, small intestine (guinea

pigs), 566

tachykinin, ligand-binding properties,

cloned cDNAs in mammalian cells

(rats), 968

thromboxane A2, homologous downregu-lation, K562 cells, 228

Reddy, N., see Thibeault, D. W., 444

Redmond, D. E., Jr., see Elsworth, J. D., 595

Regal, J. F., see Fraser, D. G., 1213

Rego, A., Vargas, R., Cathapermal, S., Ku-

wahara, M., Foegh, M. L. and Ram-well, P. W. Systemic vascular effectsof cyclosporin A treatment in nor-

motensive rats, 905

Reith, M. E. A., Jacobson, A. E., Rice, K.C., Benuck, M. and Zimanyi, I. Effect

of metaphit on dopaminergic neuro-

transmission in rat striatal slices: In-

volvement of the dopamine trans-

porter and voltage-dependent sodiumchannel, 1188

Ren, L.-M., Furukawa, Y., Karasawa, Y.,

Murakami, M., Takei, M., Narita, M.

and Chiba, S. Differential inhibitionof neuropeptide Y on the chrono-

tropic and inotropic responses tosympathetic and parasympatheticstimulation in the isolated, perfuse

dog atrium, 38

Rengasamy, A. and Johns, R. A. Character-ization of endothelium-derived relax-ing factor/nitric oxide synthase from

bovine cerebellum and mechanism ofmodulation by high and low oxygentensions, 310

Renin

cardiovascular effects of adenosine A2 ag-

onists, ligands (rats), 1203

increased secretion and blood pressure,

DO!, 5-HT2 receptors (rats), 58

inhibition of thromboxane synthetase,

antihypertensive action, angiotensin-converting enzyme (rats), 219

secretion, ionophore-induced stimulation,

chemiosmotic hypothesis (rabbits),

211

Renin-angiotensin system, pharmacology ofDuP 532 (rats), 861

Resin acids, dehydroabietic acid, p-amino-

hippurate transport, renal mem-

branes (rats), 156

Reye’s syndrome, inhibition by salicylicacid, oxidation, long chain fatty acids(mice), 894

Reynolds, I. J., Baron, B. M. and Edwards,M. L. 1,10-bis(Guanidino)decane in-

hibits N-methyl-D-aspartate re-

sponses in vitro and in vivo, 626Rhinitis, environmental tobacco smoke,

intranasal capsaicin, symptoms and

mediator release (humans), 1323

Rice, K. C., see Drower, E. J., 725Rice, K. C., see Reith, M. E. A., 1188

Rice, K. C., see Rogawski, M. A., 30

Rice, P. J., Hardin, J. C., Hamdi, A. andAbraham, S. T. Imidazoline desensi-tization of epinephrine responses inrat vas deferens, 1182

Rimcazole, sigma ligands, contractile re-

sponses (rats), 22

Ringel, I. and Horwitz, S. B. Effect of alka-

line pH on taxol-microtubule inter-

actions, 855

Ritanserin, increased renin secretion andblood pressure, DO!, 5-HT2 receptors(rats), 58

Rittenhouse, P. A., Bakkum, E. A. and Van

De Kar, L. D. Evidence that the se-rotonin agonist, DOI, increases reninsecretion and blood pressure through

both central and peripheral 5-HT2receptors, 58

Rittenhouse, P. A., see Levy, A. D., 495

Ro 09-0198, stimulation of sodium trans-port, duramycin, colonic epithelia

(humans), 1050

Ro 24-4736, pharmacology (guinea pigs,dogs, humans), 78

Ro 24-5913, pharmacologic actions (hu-mans, guinea pigs), 751

Roberts, M., Hladky, S. B., Pickles, R. J.

and Cuthbert, A. W. Stimulation of

sodium transport by duramycin in

cultured human colonic epithelia,

1050

Roberts, S. P., see Hieble, J. P., 643

Robertson, G. S., see Damsma, G., 1064

Rogawski, M. A., Yamaguchi, S-I., Jones,S. M., Rice, K. C., Thurkauf, A. and

Monn, J. A. Anticonvulsant activity

of the low-affinity uncompetitive N-

methyl-D-aspartate antagonist (±)-5-

aminocarbonyl-10,i i-dihydro-5H-di-

benzo[a,d]cyclohepten-5,10-imine(ADCI): Comparison with the struc-

tural analogs dizocilpine (MK-801)

and carbamazepine, 30

Romm, E., see Marks, M. J., 392Roncucci, R., see Carfagna, N., 356Rossi, A. C., see Buonamici, M., 345

Rossi, A. C., see Carfagna, N., 356

Roth, R. H., see Elsworth, J. D., 595

Rouleau, J. R., see Turgeon, J., 789Rouveix, B., see Coutant-Perronne, V., 1059

Rouveix, B., see Starec, M., 745

RP 52891, see Aprikalim

Ru 486, morphine administration, liver me-tallothionein, zinc metabolism (rats),

274

Rubanyi, G., Iqbal, A., Schwartz, A. and

Vanhoutte, P. M. Vascular actions ofTA3090, a novel analog of diltiazem:

Interaction with endothelium-de-

pendent relaxation in canine femoraland coronary arteries, 639

Rubin, R. H., see Fischman, A. J., 1351

Rudy, A. C., Knight, P. M., Brater, D. C.and Hall, S. D. Stereoselective me-

tabolism of ibuprofen in human: Ad-

ministration of R-, S- and racemic

ibuprofen, 1133Ruffolo, R. R., Jr., see Hieble, J. P., 643

Rustan, T. D., see Hem, D. W., 699Ryan, J. W., see Chen, X., 1301

Sabouni, M. H., Cushing, D. J., Makujina,

S. R. and Mustafa, S. J. Inhibition ofadenylate cyclase attenuates adeno-

sine receptor-mediated relaxation in

coronary artery, 508Sacaan, A. I., Monn, J. A. and Schoepp, D.

D. Intrastriatal injection of a selec-

tive metabotropic excitatory amino

acid receptor agonist induces contra-

lateral turning in the rat, 1366Saha, J. K., Sengupta, J. N. and Goyal, R.

K. Effects of bradykinin and brady-

kinin analogs on the opossum lower

esophageal sphincter: Characteriza-

tion of an inhibitory bradykinin re-

ceptor, 265

Sakanashi, M., see Noguchi, K., 732Sakurada, S., see Sakurada, T., 205Sakurada, T., Yamada, T., Tan-No, K.,

Manome, Y., Sakurada, S., Kisara,

K. and Ohba, M. Differential effects

of substance P analogs on neurokinin

1 receptor agonists in the mouse

spinal cord, 205

Saldivia, V., see Carmichael, F. J., 403Salicylic acid, inhibition of activation, oxi-

dation of long chain fatty acids,

Reye’s syndrome (mice), 894

Salivary gland, functional studies in sub-

mandibular duct cell line, subtype,

nucleotides, 1344

Sancho, C., see Lopez, M. G., 279Sandrin, S., see Carmichael, F. J., 403

Sanz, M. C. A., see Levy, A. D., 495

Sarcoplasmic reticulum, bronchial smooth

muscle membrane potential, depolar-

izing agents (dogs), 110

Sargent, C. A., Smith, M. A., Dzwonczyk,

S., Sleph, P. G. and Grover, G. J.

Effect of potassium chnnel blockade

on the anti-ischemic actions of me-

chanistically diverse agents, 97

Sarges, R., see Nikodijevi#{233}, 0., 286

Sasaki, H., see Ohrui, T., 371

Sato, C., see Katsuragi, T., 513

Savi, P., see Herbert, J. M., 44

Sawada, Y., see Matsushita, H., 620

Sawynok, J., see Sweeney, M. I., 1013

Sayet, I., see Rakotoarisoa, L., 164

SC-46275, low oral bioavailability (dogs),

1004

Schalekamp, M. A. D. H., see Boomsma, F.,

551

Scheinin, H., see MacDonald, E., 848Scheinin, M., see MacDonald, E., 848

Scherlag, B. J., see Patterson, E., 558Schindler, C. W., see Lamb, R. J., 1165

Schoepp, D. D., see Sacaan, A. I., 1366

Schuster, S. V., see James, M. K., 712

Schwartz, A., see Rubanyi, G., 639

Schwinn, D. A., Correa-Sales, C., Page, S.0. and Maze, M. Functional effects

of activation of alpha-i adrenocep-

tors by dexmedetomidine: In vivo and

in vitro studies, 1147

Secrest, R. J., see Joshi, S. N., 71

Segu, L., see Boulenguez, P., 1360

Seidler, F. J., see Nye, H. E., 976

Seizures

anticonvulsant activity, 5-aminocar-

bonyl-10,11-dihydro-5H-dibenz[a,d]cyclohepten -5, 10-imine (mice, rats),

30

GABA-mediated inhibition in inferior

1422 Index Vol. 259

colliculus, potentiation by ethanol

(rats), 1288

Sekizawa, K., see Ohrui, T., 371Selegiline, locomotor activity, dopaminergic

neurotransmission, firing rate of ni-

gral dopamine neurons (rats), 841

Selig, W. M., see Crowley, H. J., 78

Sengupta, J. N., see Saha, J. K., 265

Serotoninagonist DO!, increased renin secretion

and blood pressure, 5-HT2 receptors(rats), 58

binding sites, discriminative-stimulus ef-

fects, quipazine and l-5-hydroxytryp-

tophan (pigeons), 772

cocaine-induced elevation, plasma adren-ocorticotropin hormone, corticoster-

one (rats), 495

ethanol-induced alterations, thermoregu-

lation, long-sleep and short-sleep

mice, 833

imipramine as a discrimnative stimulus(pigeons), 1088

-induced endothelium-dependent relaxa-tion, bovine coronary artery, 1316

intracerebroventricular morphine release,adenosine and adenosine 3’,5’-cyclic

monophosphate, spinal cord (rats),

1013

mechanisms underlying benzamide-in-duced gastroprokinesis (rats), 501

modification of cardiovascular function,1-(2,5-dimethoxy-4-iodophenyl)-2-

aminopropane (rats), 1027responses of extrapyramidal and limbic

neuropeptides, fenfluramine admin-

istration (rats), 1197Serotonin-O-carboxymethyl-glycyl-tyrosi-

namide, pharmacological character-ization (rats, guinea pigs), 1360

Shah, D. H., see Hieble, J. P., 643

Sharma, S. D., see Weber, S. J., 1109Sheng, H., see !shii, K., 1102

Shi, S.-Q., see Cardoso, P. F. G., 1271Shirayama, T., !noue, D., !noue, M., Tat-

sumi, T., Yamahara, Y., Asayama, J.,

Katsume, H. and Nakagawa, M.Electrophysiological effects of so-

dium channel blockers on guinea pig

left atrium, 884Shirotani, M., Yui, Y., Hattori, R. and Ka-

wai, C. A new type of vasodilator,HA1077, an isoquinoline derivative,

inhibits proliferation of bovine vas-

cular smooth muscle cells in culture,

738

Shukla, K., see Su, T.-P., 543

Simson, P. E., Criswell, H. E. and Breese,G. R. Ethanol potentiates -y-amino-butyric acid-mediated inhibition in

the inferior colliculus: Evidence for

local ethanol/’y-aminobuytyric acid

interactions, 1288

Sinclair, I., see Fischman, A. J., 1351

Sinet, M., see Starec, M., 745

Singh, N., see Hanson, G. R., 1197

Sirois, P., see De Brum-Fernandes, A. J.,1035

Skaper, S. D., Leon, A. and Facci, L. Deathof cultured hippocampal pyramidal

neurons induced by pathological ac-

tivation of N-methyl-D-aspartate re-ceptors is reduced by monosialogan-

gliosides, 452

SKF 10047, sigma-like binding sites, hybrid

cells line NG1O8-15, 479

SK&F 104078, SK&F 104856 and, alpha-2adrenoceptor subtypes, NCB2O cells

and guinea pig lung, 1124

SK&F 104856, functional subclassification,

alpha-2 adrenoceptors (dogs, rabbits,humans, guinea pigs), 643

Sleep, ethanol-induced alterations of ther-moregulation, serotonergic invovle-

ment (mice), 833Sleph, P. G., see Sargent, C. A., 97Slotkin, T. A., see Nye, H. E., 976

Smith, C. B., see Walker, E. A., 772

Smith, M. A., see Sargent, C. A., 97Smith, R. D., see Wong, P. C., 861Sodium, transport, duramycin, colonic epi-

thelia (humans), 1050Sodium 2,3-dimercaptopropane-1-sulfo-

nate, determination and metabolism(humans), 808

Sodium butyrate, up-regulation of sigmaopioid receptors, neuroblastoma hy-

brid cells, 302Sodium channel

blockers, electrophysiological effects,atrium (guinea pigs), 884

dopaminergic neurotransmission, effectof metaphit, striatal slices (rats),

1188

Soejima, 0., see Katsuragi, T., 513Sokol, P. P. Mechanism of vancomycin

transport in the kidney: Studies inrabbit renal brush border and baso-lateral membrane vesicles, 1283

Solana, R. P., see Broomfield, C. A., 633

Solymoss, B. C., see Nattel, S., 939

Somatostatin, inhibition of release, GABABreceptors, cerebrocortex nerve tar-minals (rats), 1153

Sonderfan, A. J., see Thibeault, D. W., 444Sotalol, arrhythmogenic activities, atrioven-

tricular block (dogs), 871Sozio, R. S., see Mann, W. A., 1231Spaethe, S. M., see Bendele, A. M., 169Spano, P., see Carruba, M. 0., 124

Sphincter, lower esophageal, bradykininand bradykinin analogs (opossums),265

Spielberg, S. P., see Cribb, A. E., 1241Spinal cord

dynorphin-induced depression, dorsalroot potential (rats), 608

intracerebroventricular morphine release,adenosine and adenosine 3’,S’-cyclicmonophosphate (rats), 1013

selective antagonism by naltrindole,

cydlic[D-penicillamine2-D-

penicillamine5j enkephalin (rats),

725substance P analogs, neurokinin 1 recep-

tor agonists (mice), 205

thoracic, 5-HT1c2 agonists (rats), 1335Spino, M., see Cardoso, P. F. G., 1271SR 27417, biochemical and pharmacological

activities (rabbits, humans), 44Stapelfeld, A., see Drower, E. J., 725Starec, M., Rouveix, B., Sinet, M., Chau, F.,

Desforges, B., Pocidalo, J.-J. and Le-chat, P. Immune status and survivalof opiate- and cocaine-treated miceinfected with friend virus, 745

Staurosporine

hypoxic pulmonary vasoconstriction, van-adate (rats), 666

specific inhibitor ofprotein kinase C, cor-onary arteries (pig), 1019

Steatosis, inhibition by salicylic acid, oxi-

dation, long chain fatty acids (mice),894

Steketee, J. D. and Kalivas, P. W. Sensiti-zation to psychostimulants and stressafter injection of pertussi toxin intothe AlO dopamine region, 916

Stewart, P. and Isaac, L. Dynorphin-in-duced depression of the dorsal rootpotential in rat spinal cord: A possi-

ble mechanism forpotentiation of theC-fiber reflex, 608

Stiles, G. L., see Stille, C. J., 925Stille, C. J. and Stiles, G. L. Methylxanthine

treatment of smoothmuscle cells dif-ferentially modulates adenylate cy-clase responsiveness, 925

Stolfi, A., see Dise, T. L., 535Stomach, cisapride action on muscarinic re-

ceptors, contraction, gastric myo-cytes (guinea pigs), 1294

Strauss, H. W., see Fischman, A. J., 1351Strebel, L. C., see Lam, S. C. T., 1371

Streptokinase, plasminogen activators andantiplatelet agents, rapid dissocia-

tion, platelet-rich fibrin clots (hu-mans), 1371

Stress

morphine administration, liver metallo-thionein, zinc metabolism (rats), 274

psychostimulants and, pertussis toxin in-

jection, AlO dopamine region (rats),916

Striatumacetylcholine release, dopaminergic regu-

lation, Dl and NMDA receptors(rats), 1064

dopaminergic neurotransmission, effectof metaphit (rats), 1188

3,4-methylenedioxymethamphetamine,

induced dopamine release, microdi-alysis studies (rats), 820

muscarinic stimulation, adenylate cyclase

activity, olfactory bulb (rats), 680responses of extrapyramidal and limbic

neuropeptides, fenfluramine adinin-istration (rats), 1197

synaptosomes, dopamine release, D,L-a-

amino-3-hydroxy-5-methyl-4-isoxa-zole propionate receptors (rats), 692

Strophanthidin, low concentrations, mech-anism, positive inotropy (sheep), 182

Sturm, M., see Nies, A. S., 590

Su, T.-P., Wu, X.-Z., Cone, E. J., Shukla,K., Gund, T. M., Dodge, A. L. andParish, D. W. Sigma compounds de-rived from phencyclidine: Identifica-tion of PRE-084, a new, selective

Sigma ligand, 543Suarez-Kurtz, G., Garcia, M. L. and Kac-

zorowski, G. J. Effects of charybdo-toxin and iberiotoxin on the sponta-neous motility and tonus of differentguinea pig smooth muscle tissues, 439

Submandibular duct cells, functional stud-

ies, receptor subtype, nucleotides,

1344

Substance Panalogs, neurokinin 1 receptor agonists,

spinal cord (mice), 205binding to high-affinity NK-i receptors,

lung membranes (guinea pigs), 146capsaicin-sensitive and cholinergic

1991 Index 1423

nerves, functional interactions, bron-chus (guinea pigs), 104

responses of extrapyramidal and limbicneuropeptides, fenfluramine admin-

istration (rats), 1197

Substantia nigradeprenyl, locomotor activity, dopami-

nergic neurotransmission (rats), 841locus ceruleus and, neurotoxic effects, 1-

methyl-4-phenyl-i,2,3,6-tetrahydro-

pyridine (mice), 1379

Sudden death, actions of intravenous mag-nesium, ventricular arrhythmias,acute myocardial infarction (dogs),939

Sufentanil, opioid receptor activity, GI

87084B (guinea pigs, rats, mice), 712

Sugiyama, Y., see Matsushita, H., 620Sulfhydryl, modifying agents, substance P

binding, lung membranes (guinea

pigs), 146Sulpizio, A. C., see Hieble, J. P., 643

Sultroban, renal effects and elimination(dogs), 1231

Sun, Y.-D. and Benishin, C. G. Effects ofcalcitonin gene-related peptide on

longitudinal muscle and myentericplexus of guinea pig ileum, 947

Sung, Y. J., see Hu, S. C., 1379Superoxide, responses of aorta, ultraviolet

irradiation of solutions (rabbits),1140

Suzuki, H., see Matsushita, H., 620Swanson, K. L., Aronstam, R. S., Wonna-

cott, S., Rapoport, H. and Albuquer-que, E. X. Nicotinic pharmacology ofanatoxin analogs. I. Side chain struc-ture-activity relationships at periph-

eral agonist and noncompetitive an-tagonist sites, 377

Swanson, K. L., see Wonnacott, S., 387Sweeney, M. I., White, T. D. and Sawynok,

J. Intracerebroventricular morphinereleases adenosine and adenosine 3’,5’-cyclic monophosphate from thespinal cord via a serotonergic mech-anism, 1013

Sympathetic nervous system, age-related

changes, neurotransmission, kidney

(rats), 176Synaptosomes

cerebral cortical, tetraphenylphosphon-ium accumulation, nicotine-induced

changes in membrane potential

(rats), 1118cerebrocortex nerve terminals, GABAB

receptors, inhibition of somatostatinrelease (rats), 1153

striatum, dopamine release, D,L-a-amino-3-hydroxy-5-methyl-4-isoxazole pro-

pionate receptors (rats), 692Szeto, H., see Grasing, K., 464

TA3090block of neuronal Ca� influx (rats), 430vascular actions, femoral and coronary

arteries (dogs), 639

Tachykinin

receptors, ligand-binding properties(rats), 968

substance P binding, high-affinity NK-1

receptors, lung membranes (guineapigs), 146

Tachyphylaxia, catecholarnine, beta adre-noceptors, adipose tissue (humans),317

Taira, N., see Kageyama, M., 1019

Takahashi, H., see Echizen, H., 953

Takanaka, A., see Ohara-!maizumi, M., 484Takeda, M., see Miyata, K., 15, 815Takei, M., see Ren, L.-M., 38Takishima, T., see Ohrui, T., 371Tang, A. H., Franklin, S. R., Himes, C. S.

and Ho, P. M. Behavioral effects ofU-78875, a quinoxalinone anxiolytic

with potent benzodiazepine antago-

nist activity, 248

Tan-No, K., see Sakurada, T., 205

Tatsumi, T., see Shirayama, T., 884Taxol, -microtubule interactions, effect of

alkaline pH, 855Taylor, D. A., Leedham, J. A., Bennett, L.

E. and Fleming, W. W. Effects of

GABA in the morphine-tolerant lon-

gitudinal muscle, myenteric plexuspreparation of the guinea pig, 1084

Taylor, D. A., see Gould, E. M., 1008

Taylor, D. A., see Kong, J.-Q., 653Taylor, D. A., see Leedham, J. A., 295

Taylor, J. R., see Elsworth, J. D., 595

Taylor, T. M., see Lam, S. C. T., 1371

Teramoto, N., see Kamouchi, M., 1396

Tetraphenylphosphonium, accumulation,

cerebral cortical synaptosomes, nic-otine-induced changes in membranepotential (rats), 1118

Tham, C.-S., see Damsma, G., 1064

Theophylline, A1- and A2-selective adeno-

sine agonists and antagonists, behav-

ioral effects (mice), 286

Thermoregulation, ethanol-induced altera-tions, serotonergic involvement,

long-sleep and short-sleep mice, 833Thibeault, D. W., Downing, G., Reddy, N.,

Sonderfan, A. J. and Parkinson, A.

Oxygen-induced lung damage in new-

born rats, potentiated by 3-methyl-

cholanthrene, a P-450 induceer, andlack ofprotection by cemetidine, a P-450 inhibitor, 444

Thijssen, H. H. W., see Drieman, J. C., 766Thomas, G. and Ramwell, P. W. Effects of

guanidino compounds on the endo-

thelium-derived relaxing factor in-

hibitor NG�monomethyl L-arginine,

490

Thor, K. B., see Helke, C. J., 1335

Thromboembolism, properties of syntheticpolyanions (humans), 8

Thromboxane, renal effects and elimina-tion, sulotroban (dogs), 1231

Thromboxane A2, presystemic acetylationof platelets, aspirin (humans), 1043

Thromboxane synthetase, inhibition andpotentiation of antihypertensive ac-tion, angiotensin-converting enzyme

inhibitor (rats), 219Thurkauf, A., see Rogawski, M. A., 30Tillement, J. P., see Zini, R., 414Timmermans, P. B. M. W. M., see Cogan,

M.G., 687

Timmermans, P. B. M. W. M., see Wong,

P. C., 861

Tobacco smoke, environmental, intranasalcapsaicin, symptoms and mediator

release (humans), 1323

Tokunaga, T., see Katsuragi, T., 513Tolbutamide, glibenclamide and, hyperpo-

larization of denervated skeletalmuscle, lemakalim (mice), 932

Tong, J., see Cardoso, P. F. G., 1271

Tonus, spontaneous motility and, charyb-dotoxin and iberiotoxin, smoothmuscle tissues (guinea pigs), 439

Tosyl-L-arginine methyl ester, environmen-

tal tobacco smoke, intranasal capsai-cm, symptoms and mediator release(humans), 1323

Townley, R. G., see Agrawal, D. K., 1

Trachea, acetylcholine-induced contraction,chemical oxidant, cholinesterase in-hibition (rats), 371

Tramontana, M., see Geppetti, P., 759

Transthyretin, oxidation products of nor-

epinephrine, binding, plasma pro-

teins, 551Treistman, S. N., see Wang, X., 705Tryptophan hydroxylase, ethanol-induced

alterations of thermoregulation, se-

rotonergic involvement, long-sleepand short-sleep mice, 833

Tsai, B. S., see Perkins, W. E., 1004

Tseng, L. F., see Rady, J. J., 1073

Tseng, L. F. and Collins, K. A. Involvementof Epsilon and Kappa opioid recep-

tors in inhibition of the tail-flick re-

sponse induced by bremazocine in the

mouse, 330

Tsutsumi, R., see Miyata, K., 15, 815

Tubulin, taxol-microtubule interactions, ef-fect of alkaline pH, 855

Tunney, A., see Nies, A. S., 590Turgeon, J., Fiset, C., Gigu#{232}re,R., Gilbert,

M., Moerike, K., Rouleau, J. R.,Kroemer, H. K., Eichelbaum, M.,

Grech-B#{233}langer, 0. and B�langer, P.M. Influence of debrisoquine pheno-type and of quinidine on mexiletinedisposition in man, 789

Turmel, N., see Nattel, S., 939Turner, J. T., see Yu, H., 1344Tyrosine aminotransferase, receptor/gene-

mediated pharmacodynamics, effectof ketoconazole, methylprednisolone

pharmacokinetics (rats), 826

U-78875, behavioral effects (rats), 248

Ultraviolet irradiation, responses of aorta,

nitric oxide and superoxide (rabbits),1140

Undem, B. J., see Myers, A. C., 104UP 5145-52, pharmacological profile, origi-

nal antiulcer and antisecretory agent

(rats), 190

Uridine, nitrobenzylthioguanosine-sensitive

and -resistant nucleoside transport,Ehrlich ascites tumor cells, 799

Valette, G., see Herbert, J. M., 44Valinomycin, ionophore-induce stimula-

tion, renin secretion, chemiosmotic

hypothesis (rabbits), 211Vanadate, hypoxic pulmonary vasoconstric-

tion (rats), 666Vancomycin, mechanism of transport, kid-

ney (rabbits), 1283Van De Kar, L. D., see Levy, A. D., 495Van De Kar, L. D., see Rittenhouse, P. A.,

58

Vandongen, R., see Nies, A. S., 590

Vanhoutte, P. M., see Morrison, K. J., 198

Vanhoutte, P. M., see Rubanyi, G., 639Vargas, R., see Rego, A., 905

Vas deferens

ATP-evoked ATP release system (guinea

pigs), 513contraction, diurnal variation, presyn-

1424 Index Vol. 259

aptic nicotinic receptors and pineal

function (rats), 614

imidazoline desensitization, epinephrineresponses (rats), 1182

opioid receptor activity, GI 87084B(guinea pigs, rats, mice), 712

Vasoactive agents, role of endothelium, he-

patic vessels (dogs), 71Vasoconstriction, hypoxic pulmonary, van-

adate (rats), 666Vasodilation

E4080, ionic currents, smooth muscle

cells of portal vein (rabbits), 1396

enhanced inhibitory modulation, cycloox-ygenase products, noradrenergic neu-

rotransmission (rats), 1174

Vasopressin

calcium currents and peptide release, in-

hibition by ethanol, neurohypophy-

sial terminals (rats), 705

modification of cardiovascular function,i-(2,5-dimethoxy-4-iodophenyl)-2-

aminopropane (rats), 1027

water diuretic effect, alpha adrenoceptor

agonist AGN 190851 (rats, dogs,

monkeys), 1277

Vasorelaxation, nicorandil, potassium chan-

nel opening, guanylate cyclase stim-

ulation (rats), 526Vassalle, M., see Aceto, E., 182

Vein, functional subclassification, alpha-2adrenoceptors (dogs, rabbits, hu-

mans, guinea pigs), 643

Ventrolateral medulla, excitatory aminoacids, requirements for breathing(cats), 1388

Vigano, T., see Geppetti, P., 759

Virtanen, R., see MacDonald, E., 848Voelkel, N. F. and Czartolomna, J. Vana-

date potentiates hypoxic pulmonary

vasoconstriction, 666

Walden, R., see Pritchard, J. B., 156

Walker, E. A., Yamamoto, T., Holling-

sworth, P. J., Smith, C. B. and

Woods, J. H. Discriminative-stimu-lus effects of quipazine and I-5-hy-droxytryptophan in relation to sero-

tonin binding sites in the pigeon, 772

Walton, D. P., see Abrahams, T. P., 1388

Wang, H.-Y., see Johnson, M. D., 255

Wang, W., see Ashton, P., 719

Wang, X., Dayanithi, G., Lemos, J. R.,

Nordmann, J. J. and Treistman, S.N. Calcium currents and peptide re-lease from neurohypophysial termi-nals are inhibited by ethanol, 705

Wang, X.-L., Wettwer, E., Gross, G. andRavens, U. Reduction of cardiac out-ward currents by Alpha-i adrenocep-

tor stimulation: A subtype-specificeffect?, 783

Warfarin, renal selective N-acetyl-L-y-glu-tamyl prodrugs (rats), 766

Warner, T. D., see Ishii, K., 1102Water, diuretic effect, alpha adrenoceptor

agonist AGN 190851 (rats, dogs,

monkeys), 1277

Webb, D., see Fischman, A. J., 1351

Webb, R. L., Barclay, B. W. and Graybill,S. C. Cardiovascular effects of aden-

osine A2 agonists in the consciousspontaneously hypertensive rat: A

comparative study of three structur-ally distinct ligands, 1203

Weber, S. J., Greene, D. L., Sharma, S. D.,Yamamura, H. I., Kramer, T. H.,Burks, T. F., Hruby, V. J., Hersh, L.

B. and Davis, T. F. Distribution andanalgesia of [3H][D-Pen2,D-Pen5]en-

kephalin and two halogenated ana-

logs after intravenous administra-

tion, 1109Weiner, N., see French, T. A., 833

Weiss, S., see Fischman, A. J., 1351

Weissenburger, J., Davy, J.-M., Ch#{233}zalviel,

F., Ertzbischoff, 0., Poirier, J. M.,

Engel, F., Lain#{233}e, P., Penin, E.,

Mott#{233},G. and Cheymol, G. Arrhyth-mogenic activities of antiarrhythmic

drugs in conscious hypokalemic dogs

with atrioventricular block: Compar-

ison between quinidine, lidocaine,

flecainide, propranolol and sotalol,871

Welton, A. F., see Crowley, H. J., 78

Welton, A. F., see O’Donnell, M., 751Welzel, G. E., see Mann, W. A., 1231Wettwer, E., see Wang, X.-L., 783

Wexler, R. R., see Wong, P. C., 861

White, T. D., see Sweeney, M. I., 1013

Wolf, C. R., see Pons, C., 1328Wong, P. C., Hart, S. D., Chiu, A. T., Her-

blin, W. F., Carini, D. J., Smith, R.

D., Wexler, R. R. and Timmermans,P. B. M. W. M. Pharmacology of DuP532, a selective and noncompetitiveAT1 receptor antagonist, 861

Wong, P. C., see Cogan, M. G., 687Wonnacott, S., Jackman, S., Swanson, K.

L., Rapoport, H. and Albuquerque, E.x. Nicotinic pharmacology of ana-

toxin analogs. II. Side chain struc-ture-activity relationships at neu-ronal nicotinic ligand binding sites,387

Wonnacott, S., see Swanson, K. L., 377

Wood, M. D., see Hieble, J. P., 643

Woodhouse, D. P., see Aharony, D., 146Woods, J. H., see Walker, E. A., 772

Wu, X.-Z., see Su, T.-P., 543

Xanthines, A1- and A2-selective adenosine

agonists and antagonists, behavioral

effects (mice), 286Xiong, Z., see Kamouchi, M., 1396

Yamada, T., see Sakurada, T., 205Yamaguchi, S.-!., see Rogawski, M. A., 30Yamahara, Y., see Shirayama, T., 884

Yamamoto, K., see Yamashita, Y., 1256Yamamoto, T., see Walker, E. A., 772Yamamura, H. I., see Weber, S. J., 1109

Yamano, M., see Miyata, K., 15, 815Yamashita, Y., Yukimura, T., Miura, K.,

Okumura, M. and Yamamoto, K. Ef-fects of endothelin-3 on renal func-

tions, 1256Yamauchi, K., see Ohrui, T., 371Yamazaki, J., Fujita, N. and Nagao, T. No.

Monomethyl-D-arginine-induced

pressor response at developmentaland established stages in sponta-neously hypertensive rats, 52

Yanagisawa, T., see Kageyama, M., 1019Yaremko, B., see Crowley, H. J., 78Yaremko, B., see O’Donnell, M., 751YMO6O

pharmacologic profile (guinea pigs, dogs,rabbits, rats), 15

serotonin receptor blocking activities(rats), 815

Yohimbine, alpha-2C adrenoceptors, opos-

sum kidney, OK cell line, 323Yoneda, Y. and Ogita, K. Heterogeneity of

the N-methyl-D-aspartate receptorionophore complex in rat brain, asrevealed by ligand binding tech-niques, 86

Young, P., see Hieble, J. P., 643Yu, H. and Turner, J. T. Functional studies

in the human submandibular ductcell line, HSG-PA, suggest a secondsalivary gland receptor subtype fornucleotides, 1344

Yui, Y., see Shirotani, M., 738Yuki, H., see Miyata, K., 15, 815Yukimura, T., see Yamashita, Y., 1256

Zeiller, P., see Klauser, R. J., 8Zhang, L. and Barrett, J. E. Imipramine as

a discriminative stimulus, 1088Zidovudine, nonprimate animal model,

pharmacokinetics in humans, 1261Zimanyi, I., see Reith, M. E. A., 1188

Zini, R., Morin, D., Martin, P., Puech, A. J.and Tillement, J. P. Interactions offlerobuterol, and antidepressant drugcandidate, with Beta adrenoceptors

in the rat brain, 414

Zini, S., Ben-An, Y. and Ashford, M. L. J.

Characterization of sulfonylurea re-

ceptors and the action of potassium

channel openers on cholinergic neu-rotransmission in guinea pig isolated

small intestine, 566Zuzack, J. S., see Grant, T. L., 1158

NOTICE TO CONTRIBUTORS

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each volume, or copies may be obtained from the editor. Beginning October 1 , 1991,

all new manuscripts and correspondence concerning them should be sent to the

incoming editor:

Dr. John A. Harvey

The Journal of Pharmacology & Experimental Therapeutics

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