A ABEL, P., 185-187, 476 ABERLE, D. F., 121 ABRAHAMOV, A., 116, 120,408 ACHESON, E. D., 30 ADAIR, F. L., 43 ADAM, A., 116, 120, 392,415,420 Adaptation, 4-7, 125

at cellular level, 261 Adenosine

effect on cell cultures, 195,196,202 effect on OMP-decarboxylase, 198,

199 ADINOLFI, M., 408 AEBI, H., 220 Agammaglobulinemia, 105, 265,463 AGER, J. A. M., 402 AGUS, S. G., 245, 246, 250 AKEROYD, J. H., 427 AKESON, A., 382 AKSOY, M., 368 AL-ASKARI, S., 247 ALBERS, H., 245 Albinism, 2,125 ALEDORT, L. M., 285 ALLEN, D. W., 301 ALLEN, F. H. JR., 405,427 ALLEN, J. C., 443-447, 463 ALLFREY, V. G., 209 ALLISON, A. C., 69, 71, 124, 137-149,

268, 321, 408, 409, 415, 419, 475, 478

Allotypes, 255 ALPSTAG, H., 463 ALTER, A. A., 228 ALVING, A. S., 391,394,419 AMES, B. N., 334,342,376,406 Amino acid analog,

to halt protein synthesis, 175-176 2-Amino purine, in cell cultures, 179,

182 AMIR, A., 115 Amish, 99-114

advantages for genetic studies, 99-101

description, history, 99 rare recessive genes, 101-112

AMMAN, J., 99 AMOS, D. B., 274,462 ANDERSON, E. P., 161 Andhra Pradesh people, 81-85 ANDRI~, R., 285 ANDREWS, J. D., 104 Anemia; s e e a l s o Blood disorders,

hemolytic, hemophilia B,thal- assemia

non-spherocytic, (PK deficient) hemolytic, 105,213-221,267

clinical description, 213 biochemistry and genetics, 213,

220 sex-linked hypochromic, 265 sickle-cell, 70, 71, 137-149, 261-

264, 266-267, 333, 335-338, 342-343, 358

and malaria, 138-140, 391, 408- 409

Index Anemia, sickle-cell (cont'd)

in Africa, 137 in Greece, 142,408 in New World Negroes, 140-141,

149 locus (Hb:0 mutation rate, 137

ANFINSON, C. B., 467 ANGELETTI, P. U., 214 ANGELOPOULOUS, B., 375 ANSON, M. L., 302 Antigens

Diego, 273-295 Gc, 435-442 Gm, 463-472 transplantation, 273-283

ANTONINI, E., 354,382 APELBAUM, A., 64, 66 ARENDS, T., 87, 90 ARFORS, K. E., 71,438 ARLINGHAUS, R., 339 ARNER, G. B. L., 48, 49 ARNESON, V. G., 158 Asians, S. E., 408,409 ASKEW, D., 105 ASKONAS, A., 408 Asphyxia, post natal, of infant, ef-

fect on fertility of mother, 27 ASTER, R. n., 292 Ataxia-telangiectasia, 105 ATWATER, J., 335, 359-360, 363, 402,

4O5 Australian aborigines, 124

Gm factors, 449 rare Gc genes, 436,437, 441

Autosomes, inactivation of, 226, 268 AWAD, E., 376 8-Azaguanine, to select enzyme de-

ficient cells, 161,162 8-Azahypoxanthine,to select enzyme

deficient cells, 151 AZEVEDO, E., 70, 71, 77, 424 AZEVEDO, J. B. C., 32, 72 AZZOPARDI, J. G., 207

B BACH, F., 260,454 BACHMANN, F., 335 BAGLIONI, C., 307, 313, 329,333-335,

347-357,364-365,367,387-389, 401,403,406,412-413,479

BAHN, A. K., 30 BAIN, J. A., 189,190 BAKER, C. M. A., 327 BAKER, L., 124 BALANKURA, K., 402 BALDINI, M., 405 Baldness, 61-64, 67-68 BALLAS, A., 140, 408 BALOG, J., 301 BALUDA, M. C., 262,263 BANKS, J., 393 BANNERMAN, R. M., 368,405,409 BARAK, E., 115, 116, 120 BARNES, A. E., 434 BARNICOT, N. A., 142,408 BARR, M. L., 48 BARRAI, I., 9-20, 76 BARSKI, G., 164, 223

481

BATES, R. W., 207 BAUER, E., 245 BAUMILLER, R. C., 270 BAUR, 399 BAYLEY, W. D., 106 BAYREUTHER, K., 185, 274,277 BEALE, G. H., 159 BEARN, A. G., 201,213,322,415,420,

435-442, 478 BEATTIE, K. M., 253 BEAVEN, G. H., 327-331,352,410 BECK, W. S., 235 BECKMAN, L., 71, 77,438 BECROFT, D. M.O., 190,191,209 BEDFORD, D., 178 BEIBOER, J. L., 316,401 BEIGUELMAN, B., 71 BELL, J., 106 BEMISS, S. M., 48, 72, 73 BENACERRAF, B. J., 444 Bence Jones proteins, 316-318, 443,

444,449,452 BENDER, H. S., 99 BENDER, M. A., 177, 178, 180-182 BENERECETTI, A. S., 223-231,382 BENESCH, R., 402 BENESCH, R. E., 402 BEN-JACOB, A., 116 BENNETT, T. P., 185,334 BENOIT, F. L., 375 BENZER, S., 334,354,421,460 BERMAN, L., 151 BERNINI, L., 271,334, 354, 373,408,

415 BERNINI, R. N., 143 BERNSTEIN, F., 49, 50,291 BETKE, K., 407 BEUTLER, E., 149, 211, 253, 261-271,

331, 371, 373, 391, 397, 415, 422,424, 425, 442, 476, 477

BHANCHIT, P., 408 BIANCO, I., 348,363 BIAS, W., 177, 179,182, 183 BICKERICH, R., 144 BIERMAN, J. M., 47, 48, 69 BIGALOW, B., 467 BIGLEY, R. H., 213-221 BIORK, G., 378 BIRDSELL, J. B., 86, 124 BISHOP, 144 BJERRUM, ft., 246 BLAISDELL, R., 458 BLOCH, N., 116, 120 Blood components ; s e e antibody, an-

tigen, erythrocyte, globulin, group-specific component, haptoglobin, hemoglobin, leu- kocyte, etc.

Blood disorders; s e e a l s o anemia agammaglobulinemia, 105,265,463 hereditary persistence of F, 268,

347,359,399 hypogammaglobulinemia, 461,463 leukemia myelogenous, 268

Blood factor, Gm, 70, 93,443-447 biological evidence for antigenic-

ity, 463-466

482 INDEX

Blood factor (cont'd) chemical basis of antigenicity,

466-470 early work with, 463

Blood factor Inv, 70,443-447 Blood groups, 70, 71, 88-89,115,143-

145 ABO, 61, 70, 88, 124,429,434,464,

475 and prezygotic selection, 53-57,

60, 71 and small pox, 71 in tissue culture, 178-179

distribution, Parma valley, 14-19 MN, 57, 58, 88 P, 58 Rh, 70, 88,427,428,464

genetic control, 428,434 records available, 24 sensitive titration, 428-434

BLUMBERG, B. S., 69, 74, 124, 137, 140,143,148,408,449

BOCK, DE C., 140 BODMER, J., 285-295 BODMER, W., 285-295, 413,434, 476 BOOK, J. A., 31, 72, 73,253 BOOKER, C. R., 400 BOONYAPRAKOB, V., 402 BOOTSMA, D., 173 BORSOOK, H., 335,344,350,352 BORSTEL, H., 285 BOSCH, J. VAN DEN, 265,267 BOSCH, L. J., 285 BOURGEOIS-PICHAT, J., 42, 45-47, 49 BOWDLER, A. J., 427,434 BOWLEY, C. G., 253 BOWMAN, B. H., 435-442 BOWMAN, H. S., 105, 220 BOWMAN, J. E., 420 BoY9, J. D., 327 BOYD, W. C., 87 BOYDEN, S. V., 144 BOYER, P. D., 216, 218 BOYER, S. H., 221,333-346, 348, 375-

385, 392-394, 403, 405, 415- 417, 419, 479

BRADLEY, T. B., JR., 403,405 BRADLEY, T. R., 161 BRAIN, M. C., 365 BRAND, N., 71 BRASS, W., 138, 140 BRAUN, E. H., 285 BRAUN, P. C., 144 BRAUNITZER, G., 347-349 B~AY, G. A., 337 Brazil, population studies,

69-79,415,423 BRECY, H., 285 BREHME, K. S., 2 BRETSCHER, M. S., 354 BREWEN, J. G., 177, 179-182,476 BREWER, G. J., 93,263,394 BRIDGFORTH, E. B., 424 BRIDGES, M. T., 333 BRIDGES, P. N., 2, 106,311 BRILES, W. E., 144 BRINSON, A. G., 394 BRITTINGHAM, T. E., 285

BROCKMAN, R. W., 151,161 BRONSENBRENNER, U., 121 BROOKS, L. E., 321 BROSSEAU, G., 399 BROTHWELL, D., 93 BROUNSTEIN, S. A., 213 BROWN, D. M., 380 BROWN, G., 94 BROWN, P., 123, 124 BRUES, A. M., 61 BRUNETTI, P., 220,369, 373 BUCHANAN, K. D., 407 BUCKWOLD, A. E., 285 BUDKE, L., 173 BUETTNER-JANUSCH, J., 299 BUETTNER-JANUSCH, V., 299 BUNIM, 94 BURCH, 94 BURCKETT, L., 402 BURK, D., 214 BURKA, E. R., 365,389,405,406 BURKE, J., 140 BURKHARDT, J., 213 BURNET, F. M., 273,279 BURNETT, C. H., 190, 191,200,206 BURT, B., 259 BUSCH, D., 220 BUTLER, E. A., 327 BYRNE, R., 229

C CABANNES, R., 142 CADOGAN, L., 133 CALLENDER, S. F., 407 CAMERON, B., 376 CAMERON, D. R., 51 CAMP, W. A., 382 CAMPANA, T., 349,355 CAMPBELL, B. K., 193, 209 CAMPOS, J. DE O., 218 CANN~ H. M., 282 CAPUTO, A., 354 CARBONE, P. P., 268 CARCASS L U., 399,409 CAREY, J. N., 105 CARFAGNA, M., 235 Caries, dental, 95 CARMICHAEL, E. A., 106 CARNEIRO, D., JR., 38 Caroline Islands, 124 CARR, D. H., 48 CARSON, P. E., 391,393,394,419 Cartilage-hair hypoplasia, 107-110 CARTWRIGHT, G. E., 405 CASSIDY, P., 407 CASTRO, R., 87 Catalog of rare recessives, 110-114 CATTANACH, B. M., 253,271 Caucasoids, 36, 69-79, 87, 99-114,

394, 408, 446, 449, 450, 467 CAULTON, J., 253 CAVALLI-SFORZA, L. L., 9-20, 32, 76,

90, 113, 475 Cell cultures, human, 151-159, 192,

193,195,203-205,476-477 A B O blood groups, 178-179 alkaline phosphatase markers,

224-231 amino-acid synthesis, 207

Cell cultures, human (cont'd) antibody production, 178-179 auto-induction, 204-205 DNA reactivity, 154-157 enzyme assays, 192 enzyme requirements and

ploidy", 207-208 fibroblast tissue, 267 G-6-PD mosaics, 263 karyotypes of, 224-231 mutagens, 152-154 mutation rate spontaneous, 151-

153 tumor cells, 179,207-208 uridine, abnormal synthesis,

189-212 Cell cultures, mammalian, 167-176

colcimide, 168-171 fluorophenylalanine, 75 life cycles, 170-171 mitomycin C, 179 mutant sensitive to inducer, 200-

202 purine and pyrimidine analogs,

179 streptonigrin, 174-175 thymidine, 171-173 X-rays, 173-174,178, 180

Cell cultures, mouse fibroblast, 161- 166

enzyme-deficient mutants, 161-164, 179

hybrid formation, 164-165 segregation, 165

CEPPELLINI, R., 189, 201, 399, 402, 404, 407, 409, 478, 479

CHANGEUX, J. P., 201 CHAPLIN, H., JR., 285 CHARACHE, S., 347, 399 CHATTERJEA, J. B., 408 CHERNOFF, A. I., 333, 361, 367-369,

407, 408 CHIARELLI, B., 224 CHIEFF[, G., 235 CHILDS, B., 189, 256, 266, 334, 415,

416 Chinese, 408,449,450 CHOREMIS, C., 399 Christmas disease ; see hemophilia B Chromosome breaks

mitomycin-C induced, 179-180 puromycin, 181-182 X-ray induced, 178, 180-181

Chromosomes, human in cell culture, 159 rearrangements and protein

structure, 309, 318 Chromosome X, inactivation, 253,

257-259, 424, 477 agammaglobulinemia, 265 anemia, sex-linked, 265 choroideremia, 265, 266 color-blindness, 265,266 cytological evidence, 261,421 ectodermal dysplasia, 263,265 function, 261-265,421-423 G-6-PD, 261-264,266 heteropycnosis, 270-271

INDEX 483

Chromosome X (cont'd) muscular dystrophy, 265 ocular albinism, 265 time of, 421-425

CHUNG, A. E., 391 CHUNG, C. S., 13, 55, 57-59 CHWATT, L. J. BRUCE, 138 CIECIURA, S. J., 161,178, 192,241 CINADER, B., 455 Cistron, defined, 460 CIVIDALLI, L., 120 CLAFLIN, A., 70 CLARKE, C. A., 71,143 CLEGG, M.D., 336 CLEGHORN, T. n., 312,324 CLEVE, H., 435-440 CLOSTRES, M., 133 CLOSTRES, P., 133 CLYDE, D. F., 138,139 COHEN, F., 142,403,405,406 COHEN, M. M., 174,183,476 COHEN, S., 443,452 COHEN, T., 115-120 COHN, M., 201 COHN, N. K., 151,155, 157 COLBERG, J. E., 453 COLBOURNE, M. J., 138, 139 Colcimide, 168-171 COLE, R. D., 297,301,302,307 COLEMAN, R. D., 300 COLLERVILLE, M. DE, 133 COLOMBO, B., 347-356 Color blindness, 89, 115, 265, 419-

420 COMINGS, 404 CONLEY, C. L., 268, 347, 399, 400,

403,407 CONNELL, G. E., 71, 309, 311, 321,

324, 435,437 CONNERS, J. J., 375 CONNOR, A., 70 Consanguineous marriage, 17-19,

81-85, 113, 475 among non-Ashkenazim Jews,

115-120 bridal age, 83-84 effect on fecundity, 115 effect on mortality, 48-49 genetic load, 31-40 illiteracy and, 84 marital distance and, 75-76 parent-offspring distance and,

75-76 population effective size, 17-19 pulmonary tuberculosis, 84 sterility, 85

CONTERIO, F., 14, 15, 19 COOMBS, R. R. A., 144, 178 COON, C., 86, 122, 127 COOPER, A. J., 74, 140 COPELAND, V., 161 CORDOVA, F. A., 403 CORNEFERT, F., 164,223 CORMICK, J., 297,301,304 COTTERMAN, C. W., 77,416,424 COUVE~, L. M. J., 93 Cox, R. P., 201, 207, 227, 229, 233-

251,476, 477

CRAIG, A. P., 174 CRAIG, L. C., 317,334, 355, 387 CRAWFORD, H., 70,213 CRAWFORD, I. P., 453 CRESTFIELD, A. M., 218, 297, 301,

3O2 CREW, F. A. E., 145 CRICK, F. H. C., 312 CRISTOFFANINI, A., 283 CRow, J., 5, 6, 7, 13, 16, 31, 32, 35-37,

41, 49, 52, 69, 72, 93 CR0WELL, B. B., 391,393,395 CROZE, M., 44 CRUVEILLER, J., 253 CRUXENT, J. M., 86 CUA, J. T., 387 CUDKOWITZ, G., 278 CURTAIN, C. C., 124,408,409 CUSHING, H., 106 Cytogenetics of human chromo-

somes, 177-178

D DACIE, J. V., 213 DAHLBERG, G., 17 DAMASHEK, W., 405 DANCE, N., 327-331,352 DANCIS, J., 189 DANEK, J. J., 471 DANIELLI, J. F., 234 DANON, D., 389 DARLINGTON, C. D., 132 DAUSSET, J., 285 DAVE, P. J., 140 DAVIDSON, J. D., 161,214 DAVIDSON, R. G., 189, 256, 263, 266,

334, 415 DAVIES, J., 187, 423 DAVIS, L., 105 Deafness, congenital, 105, 106 DEBELLIS, R. H., 388-389 DECARLI, L., 223-231, 234, 237, 476,

477 DECKER, J. L., 94 DEFORANAS, B., 399 DEGNAN, T. J., 70 DEGRUCHY, G. C., 213 Dehydrogenase, lactic, 70-71 DELAISSE, J., 139 DELIYANNIS, G., 140,408 DEMARS, R., 189,201,318,415 Demography, 41-50 DEMYER, M. K. H., 259 DENING, G. IV[., 123 DERN, R. J., 391 DESSAUER, H. C., 327 DEUTSCH, H. F., 468,469 DIAMOND, J. M., 347-349 DIAMOND, L. K., 105, 220, 367, 368,

401 DINTZIS, H. M., 334, 339, 347-349,

353,354 DIXON, G. H., 71, 309, 311,321, 324,

435, 437 DJORDJEVIC, B., 154, 155 DNA, mammalian

chemical reactivity, 154-157 incorporation of thymidine ana-

logs, 155

DNA, mammalian (cont'd) induced cross-linking of, 155

DOAN, C. A., 105 DOBKIN, K., 228 DOBZHANSKY, T., 1-7, 33, 51, 68, 121,

127,475, 480 DODD, V. A., 105 DORKEN, H., 407 DORMANDY, K. M., 402 Downs syndrome; s e e mongolism D0XIADES, T., 365,398,419 DOZY, A. M., 301,330 DRAY, S., 453,455,472 DRESCHER, H., 327 DREYFUS, B., 285 DREYFUS, J. C., 263 DRINKWATER, H., 106 DRONAMRAJU, K. R., 81-84,475 Drosophila, number of loci in, 2 DRYER, W. J., 467 DUBBS, D. R., 162 DUBE, S. C., 81 DUBISHI, S., 455 DUERST, M., 307 DULBECCO, R., 280 DUMONDE, D. C., 247 DUNN, L. C., 51,460 DUNSFORD, I., 253 Dwarfism

pituitary, 111 polygenic, 111,112

DWORKIN, D., 371,399 Dystrophy

childhood muscular, 379 congenital, 379 Duchenne-type muscular, 105,

265, 378 facioscapulohumerol, 379 limb-girdle, muscular, 105,379 myotonic, 379

E EAGLE, H., 191, 192, 201, 207, 208,

224, 236, 241-243, 246-248 EARLE, W. R., 242 EASLEY, C. W., 317 ECK, R. V., 309 Ectodermal dysplasia, 263, 265, 267,

270 EDELMAN, G. M., 443,449,453,467 EDINGTON, G. M., 138,139,140,141 EDWARDS, A. W. F., 9-20, 90, 146 EDWARDS, R. G., 144 EERNISSE, J. G., 285 EFRON, M. L., 333 EGELAND, J. A., 99-114 EHRENSTEIN, VON G., 185, 334, 336,

354 EILERS, A., 124 ELDRIDGE, R., 99-114 ELLIS, M. J., 401 ELLIS, N., 424 ELLIS, R. W. B., 104 Ellis-van Creveld syndrome, 101-

105, 111,113 EMERY, A. E., 265 EMPSON, J., 424 EMSON, H. E., 285

484 INDEX

ENGLE, R. L., 382 Enzymes, human

deficient mutants, 151-154, 161- 164, 179, 183

erythrocyte pyruvate-kinase (PK) deficient in anemias, 213

induction, 202-206, 208, 229, 230, 234-251

regulation, 206, 233-251 EPHRUSSI, B., 159,164, 165, 224,477 EPSTEIN, R. B., 334 ERICKSON, R. P., 462 ERIKSON, R. L., 155 ERLANDSON, M., 358,360 ERSLEV, A. J., 402 ESCOBAR, M. A., 394 Eskimos, 124 Ethnic mixture, 115, 120 Eugenics, 3, 7,480 EVELAND, W., 94 EVERETT, C., 404

F Factor XI deficiency; see plasma

thromboplastin antecedent FAHEY, J. L., 444, 445, 449, 460-462,

472 FAINER, D. C., 333,375-385 FAIRBANKS, V. F., 253,261,415 FALCONER, D. S., 33 FALLON, H. J., 190-191,200,206,214 FALLS, H. F., 265 FAN, D. P., 345 FARIAS, A. H., 94 FARON, L. C., 96 FARR, A. L., 193 FARR, R. S., 434 FEBVAY, M., 44 FELL, H. B., 234 FELLENBERG, R. VON, 220 FENNINGER, W., 387 FERGUSON, L. C., 144 Fertility

decrease in, 27 increase in, 26-27

FESSAS, P. H., 142, 143, 353, 365, 367, 399-403,407, 409,419

Fibroelastosis, 111 FIELD, J. W., 138 FINCH, C. A., 213,405 FINKEL, A., 61, 67, 68 FINNEY, D. J., 415 FIRSCHEIN, I. a., 140, 141,265,454 FISCHER, E., 350 FISHER, B., 358 FISHER, R. A., 1,122, 139 FITZGERALD, P. H., 454 FJELDE, A., 227 FLANAGAN, C. L., 391 FLATZ, G., 143,408,409 FLEISCHMAN, J. B., 443,451,467 FLING, M., 240 FLORA, R. M., 235 FLORY, L. L., 321 Fluorophenylalanine, effect on mam-

ma]jan cells, 175 FLYNN, F. V., 327 FOGHT, M., 327 FOLLETTE, J. H., 235

FONSECA, A., 285 FORD, E. B., 6 FORTELIUS, P., 234 Founder effect, 105, 113,121,436 Founder variance, 127 Fox, W., 327 FoY, H., 138, 139,140 FRACCAaO, M., 75 FRANGIONE, B., 463-472 FRANKEL-CONRAT, H., 470 FRANKLIN, E. C., 443, 444, 449, 461,

463-472 FRASER, G. R., 399-402,408-409,413 FRAYER, Z., 408 FRECHET, ~r 42 FREGIN, A., 253 FREI, E., III , 214 FREIER, S., 116, 120 FREIRE-MAIA, A., 32, 34, 36-38, 70,

76, 77, 424, 475 FREIRE-MAIA, N., 31-41, 73, 76 FRENCH, F. E., 47, 48, 70 FR•NSTER, J. H., 267 FREVD, P., 106 FRIEDLAND, S., 334 FRIEDMAN, J., 253 FRIEDMAN, S. M., 187 FROTA-PESSOA, 0., 76, 137 FRY, E. I., 94 FUDENBERG, B. R., 464, 471 FUDENBERG, H. H., 434, 442, 443,

449, 461, 463-472, 478, 480 FULLERTON, W. T., 137, 141 FULMER, H. S., 96 FUNDERBURK, S. S., 267 FURUSHO, T., 53

G GABRIO, B. W., 213, 214 GABUZDA, T. G., 400, 402, 407 GAFNI, D., 116, 408 GAJDUSEK, D. C., 121-135, 408, 475 GALINAT, W. C., 476 GALLANGO, M. L., 90 GALLY, J. A., 443, 453 GANDINI, E., 189 GARCIA, E., 87 GARDINER, J., 43, 44 GARDNER, F. H., 400, 407 GARLICK, J. P., 71, 138, 139 GARRICK, M. D., 333-346, 348, 376 GARRY, B., 124 GARTLER, S. M., 189, 253-260, 263,

267, 422, 476, 477 GAVIN, J., 415 GAYLE, R., 214 GEIGER, IV[., 105 GELLER, S., 235, 236 Gene

control, 213, 219, 220,329-330, 420 distribution, bimodal, 90 duplication; see trisomy, 309-311,

318 flow, 68-80, 85-98, 115-120,475-476 operator, 3, 208, 333,347, 407 penetrance, 108 regulator, 200, 201, 206, 208, 209,

212, 234, 346, 347, 406 structural

Gene (cont'd) for gamma-globulin, 317 for G-6-PD, 416, 420, 423 for hemoglobin, 309, 347

Genes sex-influenced, 108-110, 129-133,

145 sex-linked, 68, 253, 257-259, 265,

266, 391, 415-425, 477 Gene action, theory of; see also

control gene, operator gene, regulator gene, structural gene, 334-335, 339, 340, 344, 345, 415

in G-6-PD synthesis, 419-423 in hemoglobin synthesis, 347, 357,

363-365, 405-407 modulation, 342, 344, 346 structure-rate hypothesis, 333,

334, 340, 341, 373, 374, 406 Genetic code, universality of, 185-

187 bacteriophage in tobacco leaves,

185 E. coti phosphatase in S e r r a t i a ,

185 induced amino acid replacements,

185 in vitro synthesis of hemoglobin,

185 Nirenberg-Matthei technique, 185 polyoma growth in B. subt i l i s ,

185 vaccinia growth in B. subt i l i s ,

185-186 Genetic defects; see also agamma-

globulinemia, anemia, cho- roideremia, color blindness, ectodermal dysplasia, muscu- lar dystrophy, orotic aciduria

affecting proteins, 189 treatment for, 7

Genetic drift, 9-14, 75-77, 113, 121- 135, 436, 475

mathematical model, 10 sampling and selective, 10

Genetic load, 5-7, 31-41, 51-53, 418- 419, 423

and inbreeding, 31-40 and prezygotic selection, 51-53 and synergism, 32-33 drive element, 51 mutational and segregational, 41,

475 test for sublethal, 418, 423

Genetics, somatic cell, 273-283 GERALD, P. S., 304, 333,367, 368, 401 GERMAN, J. L. III , 261, 267, 268,

276, 318 GERSHON, D., 164 GERSHOWITZ, H., 87, 93 GIBBS, M. B., 427, 434 GIBLETT, E., 253,321-326,475,478 GIERER, A., 349 GILBERT, W., 187 GILLESPIE, J. E. O'N., 401 GILMOUR, D. G., 144 GIsH, D. T., 470

INDEX 485

GITZELMANN, R., 285 GLADSTONE, R. J., 327 GLASS, B., 65, 82, 122, 124, 158, 177-

183, 270, 473-480 GLASSE, R., 132 GLEN-BOTT, A. M., 312,324 Globulin, beta, mouse, 455-462 Globulin, gamma; s ee a l so agamma-

globulinemia, Gm factor, 70, 95, 260, 316-318, 443-447, 455-462

chemical analysis, 443-447, 466- 470

danger of administering, 471 localization of genetic factors,

443-447, 466-470 mouse, 455-462

antigenic specificity, 456 cross reactions, 458, 459 gene segregation, 457, 461 Ig alleles, 455-461 structure, 461

Globulin, multiple myeloma, 316 GLOVER, J. S., 455 GLUCK, •., 388 Glucose-6-phosphate dehydrogen-

ase (G-6-PD), 115, 261-264, 266-267, 271, 415-425, 475, 477

abnormal, 391-398, 415-423 distribution of deficient genes,

391, 416-420 exception to sex linkage, 416, 423 genetics, 416, 419-423 normal, 391, 392

Glutathione, reduction with G-6-PD, 262, 391

GLYNN, L. E., 144 Gm; see Blood factors Goiter and PTC-tasters, 71, 72 GOLD, E. R., 445, 447 GOLDBERG, S. R., 403 GOLDBLUM, R., 449 GOLDSCHMIDT, E., 115-121,475-476 GOLDSTEIN, J., 334 GOLDSTEIN, M. A., 408 GOLDSTEIN, N. P., 248 GOMPERTZ, B., 42, 47 Gonadal dysgenesis; s e e Turner's

syndrome GOOCH, P. C., 180, 181 GOODMAN, H. IV[., 349 GORER, P. A., 274, 276 GORINI, L., 187 GORMAN, J. G., 124, 143, 265, 271,

408 GOSLINGS, N. E. O., 143 GOUTTAS, A., 402 Goux, J. M., 41-50 GRAHAM, J. B., 190, 191, 200, 206 GRANICK, S., 233 GRATZER, W. B., 401 GRAYDON, J. J., 94, 124 Greeks, 393, 398, 408, 409 GREENWALT, T. J., 434 GREENWOOD, F. C., 455 GRESHAM, G. A., 144 GREY, G., 93

GREY, H. M., 443-447 GRIFFIN, J. B., 86 GRIFFIN, M., 235-237, 245-248, 250 GRIGNANI, F., 369 GRINSTEIN, M., 366, 368 Group-specific component (Gc), 435-

442 biochemistry, 437-441 function, 436, 437, 442 gene frequency, 435-437 genetic control, 435 rare types, 436, 437

GROSS, J. B., 248 GROSS, R. T., 213,266, 393 GRUBB, R., 443, 445, 446, 463, 469 GRUMBACH, IV[. •., 266 GRUNDBACHER, F. J., 425, 434 Guam, 133 GUARACIABA, M. A., 32 GUIART, J., 124, 125 GUIDOTTI, G., 301,302, 304, 305, 348,

355, 387, 406 GI)LLBRING, B., 144 GUREVITCH, J., 115 GUTTER, F. J., 451 Gypsies, 408

H HABEL, K., 279 HABER, G. V., 70 HACKEL, E., 285, 292 HADLOW, W. J., 132 HAGA, H., 55, 56, 60 HAGIWARA, A., 155 Hair, distribution in man, 61-68 HAJNAL, J., 18, 76 HAKALA, M. T., 163 HALDANE, J. B. S., 1, 31, 41, 121,

409, 418 HALEVI, H. S., 115 HALL, G. A. M., 106 HALONEN, P., 243 HAMILTON, H. B., 189,192 HAMILTON, H. E., 399, 403 HAMILTON, J. B., 61, 62 HAMILTON, P. B., 300 HAMILTON, W. J., 327 HAMPER, J., 415 Haptoglobin, human, 71, 309-314

polymorphism, 435 properties, function, biochemis-

try, 321 variant types, 321-326

HARBOE, M., 443, 444, 446, 449, 463, 468, 469

HARDESTY, B., 339,349 HARDING, H. R., 235 Hardy-Weinberg principle, 474-475 HARRIS, H., 61, 64, 71, 72, 137, 312,

323, 324, 406 HARRIS, J., 463 HARRIS, R., 71 HARRISON, G. A., 71, 122 HART, M. VAN DER, 285 HARTMAN, P., 334, 342, 406 HASHEM, N., 454 HASS, L. F., 216 HATHAWAY, P., 333-346, 348, 376 HAUSCHKA, T. S., 261, 274

HAUT, A., 405 HAWES, l~I. D., 144 HAWKINSON, 28 HAYFLICK, L., 192, 223, 255 HECHT, F., 113, 206, 271, 327-331 HEESTERMAN, J. E., 135 HEIDELBERGER, C., 155 HELINSKI, D. R., 164, 470 HELLEMAN, P., 401 HELLER, P., 268, 300, 834, 394 HELLING, J. W., 317 HELLSTROM, I., 279, 280 HELLSTROM, K. E., 273-278, 280-282 HELMBOLD, W., 71, 144 Hemoglobin; s ee a l so Anemia, G-6,

PD abnormal, 137, 298-306, 309, 313-

318, 333, 334, 357-375; s ee

a l so anemia, thalassemia H-chain disease, 469 structural basis, 307,313-316,

347-349 structure of human, 297-308, 313-

319 synthesis

by heterozygotes, 333-346 control, 347, 357-371, 387-390 control of assembly, 352-355 control, non-genic, 365-369 in vitro, 185

types C, 348, 358, 363 D, 359 G, 387-388 I, 388 J, 347, 360 L, 348 Lepore, 307, 313, 315, 367, 401-

404, 406 O, 335, 338, 339, 342, 343 prenatal, human, 327-331, 368,

387-388, 406, 407 prenatal, persistent, 206, 268,

330,347, 369,401,406 Pylos, 367

Hemolytic anemia, 105 Hemophilia B, 105 HENDRICKSE, J. P. de, 137 HENDRICKSON, E. M., 391, 392, 395,

396, 415-417, 419, 420 HENNESSEY, 1~. A., 214 HENNING, U., 185 HEREMANS, J. F., 449, 461, 470 HEREMANS, M.-TH., 449 HERMONI, D., 115 HERTIG, A. T., 47 HERTZ, R., 208 HERZ, F., 234, 235, 236, 245 HERZENBERG, L., 462 HERZENBERG, L. A., 159, 211, 260,

282, 283, 433, 455-462, 480 HEss, E. H., 121, 124 HicKs, P., 307 HIERNAUX, J., 140, 141 HIGA, A., 345 HILL, R. J., 301, 302, 304, 306, 348 HILL, R. L., 299, 300, 302, 363, 385 HILLER M. C., 285, 292

486 INDEX

HILSCHMANN, N., 317, 348 HILSE, K., 348 HIRAIZUMI, Y., 51-60, 145, 475 HIRANO, A., 133 HIRS, C. H. W., 297 HIRSCH, F., 61, 68 HIRSCHFELD, J., 435 HIRSCHHORN, K., 260, 265, 454 HITZIG, W. H., 285 HJERP, L., 243 HOECKER, G., 274,283 HOENE, R. E., 32, 72 HOFFMAN, H. A., 455 HOFSTRA, D., 458 HOLBR0W, E. J., 144 HOLLEY, R. W., 334, 421 HOLLINGSWORTH, D. R., 71 HOLMQUIST, W. R., 387 HOLTZMAN, N. A., 335, 338 HOLZMANN, A., 412 HORIUCHI, T., 229 HOROVITZ, A., 117, 120 HOROWITZ, N. H., 240 HORSFALL, W. R., 436 HORTON, B. F., 330, 333, 360, 403 Hosoi, Y., 94 HOSTETLER, J. A., 99-114 HOWELL, R. R., 189, 191-193, 195 HOWELL-EVANS, C. A., 71 HSU, T. C., 162 HUDGINS, P. C., 375 HUEHNS, E. R., 206, 208, 221, 327-

331, 352, 355, 369, 387, 402, 405, 471, 478

HUENNEKENS, F. M., 214 HUGHES, W. L., 317 HUGULEY, C. M., 189-191, 193, 199,

2O9 HUISMAN, T. H. J., 301, 330, 333,

360, 365, 366, 403,404, 405 HULSE, F., 112 HUMFHREYS, E. W., 372 HUNT, J. A., 297, 301, 333 HUNTER, W. M., 455 HURWITZ, D., 116, 120 HUSER, H. J., 105 HUTCHISON, A. M., 253 HUTCHISON, H. E., 407 Hutterites, 112 HUTTON, J. J., 339 HUTZLER, J., 189 HUXLEY, J., 3 Hybrid formation in mutant cell

lines, 164-165 Hyderabad, 81 Hydrometrocolpos, 110, 111 Hypo-gammaglobulinemia, 471

I ICKES, C. E., 391 IGNATOV, V. G., 400, 402 IIJIMA, T., 155 IMBELLONI, J., 86, 90 Immunization, maternal, by fetal

Gm antigen, 464 Immunoglobulins, 443,444; s e e a l s o

Globulins & Isoantigens genetic control of, 461 genetic nomenclature, 462

Immunoglobulin (cont'd) mouse, 455-462

INAGAKI, Y., 106 Inbreeding; s e e Consanguineous

marriage, 72-73 effect on malformation, 72, 73

population fitness, 51 stature, 112

inbred populations, 81-120, 128- 134

India, 81-85, 408 Indian American, 69-79, 85-96

Andean, 90, 375-376 bimodality of gene distribution, 90 Chippewa, rare Gc mutant, 436,

441 diseases, 95, 96 genetic variation, 87-90, 124 Gm factors among, 449-450 Guayaki, 133-134 Macushi, 90 Navahos, 96 origin & dispersion, 85, 86 possible links with Polynesians, 94 primitive groups, 91-92 Xavante, 91-95

Ingram, K., 165 Ingram, V. M., 297, 301, 302, 304,

306, 309, 333-335, 342, 347, 348, 354, 355, 357, 363, 364, 365, 366,367,401,406

Inosinic acid pyrophosphorylase (IMPPase)

function of, 151 human cell lines lacking, 151-152

IRIARTE, L. L. G., 133 ISDALE, I. C., 94 ISLAND, D. P., 208 Island model, 14 Isoalleles; s e e polygenes, 5 Isoantigens, 273-295

genetic determination, 275, 276 histocompatibility system, 273,

274, 280 host range, 274, 280 leukocyte, 285-295

genetics, 290-292 identification, 287-290 nomenclature, 293-294 losses in tumor cell popula-

tions, 274, 280 lymphoma, 282, 283 mouse, 455-462 mutants, origin of 275-277

Israel, population studies, 115-120 ITAN0, H. A., 333,334,358, 359,364,

373, 374, 406, 421 Iwo, J., 453 ITOH, S., 54, 55, 56 IUCHI, I., 300 IVERSON, M., 462 IYER, V. N., 155-157 IZUMIYAMA, H., 53

J JACKSON, C. E., 105 JACOB, F., 3, 200, 201,206, 208, 209,

229,234,333, 346,421 JACOBS, A. S., 403

JACOBSON, D. D., 216 JAHN, E. F., 124, 427 JANDL, J. H., 144 JANSEN, V., 189 Japan, Kii peninsula, 133 Japanese, 51-60, 449 JEFFREY, D., 125 JELINEK, A. J., 86 JENKIN, C. n., 144 JENSEN, E., 462 JENSEN, K. G., 285 Jews

Ashkenazim, 149, 408 Kurdish, 116-120 Non-Ashkenazim, 115-120, 393,

398, 408 blood groups, 115 color blindness, 115 G-6-PD deficiency, 115, 120 polymorphism, 115 thalassemia, 115, 117

JIM, R. T. S., 333 JOHNSON, A. B., 396 JOHNSON, I. S., 171 JOHNSTON, A. W., 106 JONASSOHN, K., 28 JONES, R. T., 213-221, 297-308, 327,

333, 336, 387, 478 JONSSON, B., 435 JONSSON, N., 280 JONXIS, J. H. P., 141,316,375,401 JOSEPHSON, A. M., 366, 367, 371,

372, 399 JUDD, B. H., 313 JUKES, T. H., 309 JUNQUEIRA, P. C., 69, 87, 92, 95, 127,

435

K KAARS-SIJPESTEYN, J. A., 316, 401,

409 KALCKAR, H. S., 183 KALISS, N., 273, 275 KALMUS, H., 71, 115, 266 KAPLAN, A. S., 156, 157 KAPLAN, E., 358, 363 KARAKLIS, A., 367, 401 KARVE, I., 81 KATHPALIA, P. M. L., 408 KATO, Y., 237 KATTAMIS, C., 399 KATZ, A. M., 467 KAY, H. E. M., 330 KEIGHLEY, G., 350 KEiL, J. V., 206, 327, 328 KEITER, F., 69, 87, 92, 95, 435 KELETI, L., 116 KELLERMEYER, R. W., 419 KELLEY, G. G., 161 KELUS, A., 455 KEMP, D. H., 70 KENNEDY, J. M., 24 KENNEY, F. T., 235 KERR, W. E., 32, 38 KEVY, S. V., 466 KIDSON, C., 124, 408 KILLMAN, S. A., 285 KIMURA, M., 5, 10, 13, 14, 16, 18,

31, 32, 51, 72, 74, 75

INDEX 487

KINLOCH, J. D., 407 KIRK, R. L., 124, 436, 437, 449 KIRKMAN, H. N., 391-398, 415-417,

419, 420, 478 KIT, S., 162, 163 KITCHIN, F. D., 71, 72, 435-442 KITER, F., 127 KITSOS, C., 399 KJELGAARD, N. 0., 364 KLEIN, E., 273-283, 476, 477, 478 KLEIN, G., 273, 274, 276, 277, 279,

280 KLEINMAN, H., 436 KLENOW, H., 171 KLINENBERG, 191, 193, 195 KLUCKHOHN, C., 82 KNIGHT, C. A., 470 KNOPF, P. M., 334, 339, 349 KNOX, W. E., 235 KOBAYASHI, T., 53 KOCH, B., 402 KOCHHAR, B. R., 408 KOCHWA, S., 427-434 KODANI, M., 177, 179 KOLER, R. D., 213-221,299, 307, 336,

365, 402, 476, 477 KOLODNY, a., 454 KONDI, A., 138, 140 KONIGSBERG, U. R., 226 KONIGSBERG, W., 301,302, 304, 348,

355, 387 KORBER, E., 327 KOSSlKOV, K. V., 311 KOSSMAN, R. J., 375-385, 479 KOTITE, L., 376 KRAUS, A. P., 304, 306, 358, 368, 402,

403 KRAUS, B. S., 124 KREVANS, J. R., 333,347,402 KRIEGER, H., 32, 36, 38, 73, 77, 416,

424 KRILL, A., 265 KRIMBAS, C., 3,140,408 KROOTH, R. S., 183, 189-212, 476, 477 KRUSEN, D. E., 101 KUNKEL, H. G., 217, 443-447, 449,

463, 468, 472, 479 K~JNZER, W., 327 KURABAYASHI, M., 60 KURLAND, L. T., 133 Kuru, 128-133, 475 KURYU, Y., 382

L LABOR, A., 370 LAING, W. N., 138 LALEZARI, P., 285 LAMBOTTE-LEGRAND, C., 140 LAMBOTTE-LEGRAND, J., 140 LANE, J. J., 94 LANGDON, R. G., 391 LANGER, L. 0., JR., ii0 LANSET, S., 443 LARSON, L., 424 LASH, J. W., 233 LATTE, B., 408, 415 LAUGHLIN, W. S., 86 LAUGHNAN, J. R., 317 LAURELL, A. B., 443, 463

LAW, L. W., 161 LAWLER, S., 452, 467 LAWRENCE, H. S., 247 LAWRENCE, J. S., 235 LAYRISSE, M., 87, 90 LAYRISSE, Z., 87, 90 LEBOUVIER, G., 238 LEE, G. R., 405 LEE, R. C., 404 LEE, T.-C., 408 LEEUWEN, A. VAN, 285, 291 LEFEBVRE, J., 110 LEHMANN, H., 140, 141, 333, 335,

402, 407 LEHTOVAARA, R., 146 LEIF, 369 LEJEUNE, J., 146 LENNANE, G. A., 94 LENOIR, J., 443, 463 Leprosy, 125 LERoY, G. V., 391 Lethal equivalents, 41-50 Lethon, numerical estimate, 36 Leukemia, 125 Leukocyte

agglutination assay, 285-286 isoantigens in man, 285-295, 478

LA gene frequencies, 291 pyruvate kinase, 213-220

Leukoencephalopathy, metachromatic, 106

LEVADIOTTI, M., 140 LEVENE, C., 120 LEVENE, H., 3, 5, 7 LEVENE, O., 115 LEVERE, R. D., 268, 334, 335, 344 LEVIN, B. R., 86 LEVIN, W. C., 404 LEVINE, L., 208 LEVINS, 5 LEVY, M., 250 LEVINE, J., 334 LEVINTHAL, C., 345 LEVINTOW, L., 201 LEVITZ, M., 189 LEWIS, E. B., 309, 460 LEWONTIN, R. C., 5 LI, C. C., 1, 7, 41,419 LIACHOWITZ, C., 141 LICHTMAN, H. C., 268, 334, 335, 344 LIDDLE, G. W., 208 LIEBERMAN, R., 455 LIEBOLD, B., 348 LIE HONG, G., 402 LIE-INJO, L. E., 401, 402 LILIENFELD, F. A., 60 LIN, E. C. C., 235 LINDAHL, P. E., 145 LINDEMAN, R. D., 95 LINDER, D., 253-260 LINDLEY, H., 301 LINDSLEY, D. L., 51 LINGREL, J. B., 335, 344 LINHARD, J., 141 LIPMAN, L. N., 451 LIPMANN, F., 185, 349 LIPSETT, M. B., 208 LINKER, R., 299, 333

LITTAU, V. C., 209 LITTLEFIELD, J. W., 159, 161-166,

211, 231, 476, 477 LIVENGOOD, D., 171 LIVINGSTONE, F. B., 71,140, 141,142 LOCK, S. P., 402 Locus, 460 LOEHR, G. W., 369 LOGHEM, J. J. VAN, JR., 285 LOHR, G. W., 220 LONG, W., 392 LONGLEY, A. A., 51 LORKIEWICZ, Z., 154, 155 LOTZ, M., 190, 191 LOUKOPOULOS, D., 353, 399, 400 LOWE, C. R., 145 LOWENSTEIN, J., 467 LOWRY, O. H., 193 LUCCI, R., 348 LUDWIG, 5 LUNDEN, L. G., 71 LUYKEN, R., 135 LUZZATTO, L., 389-390 LYCETTE, R. R., 453 LYON, M. F., 253, 261, 265, 270, 271,

421 M

MCCALLA, K., 297 McCONNELL, R. B., 71 McCORMICK, W. F., 372 McCULLOCH, E. A., 278 McCURDY, P. R., 360, 391-398, 404 McDONALD, J. C., 143, 144 MCFALL, E., 203 McFARLAND, W., 407 McGINLEY, J. M., 363 McGINNISS, M. H., 466 McGuCKIN, W. F., 248 MCINT0SH, W., 68 McKEOWN, T., 145 McKusIcK, V. A., 99-114, 124, 266,

415, 420, 475, 476 MCLAREN, A., 146 MACLEOD, C. M., 201, 207, 227, 233-

251,476, 477 MACNEISH, R. S., 476 McQUILLEN, K., 364 Macroglobulins, WaldenstrSm, 443 MAGASANIK, B., 203 MAINARDI, M., 32 MAIO, J. J., 223-231, 234, 237 MAKEHAM, W. M., 42, 43 M~.KEL.~, O., 146 MAKINO, S., 261 MALAMOS, B., 400, 408 Malaria, falciparum, 137-149,391,

4O9 G-6-PD, and, 409 sickle trait, and, 138, 139, 409 thalassemia, and, 409

Malaysians, 408 MALCHER, G., 91 MALI~COT, G., 75 MALING, D. B., 164 MALLETT, B. J., 407 Man, genetic defects, 2

genetic diversity, 3 genetic fitness of, 3

488 INDEX

MANDY, 469 MANGE, A. P., 112 MANGELSDORF, P. C., 476 MANN, J. D., 265 MANNIK, M., 443, 444, 449, 468 MANWELL, C., 327 MARAMOROSCH, K., 186 MARANJIAN, G., 140 MARCALLO, F. A., 32, 35, 37, 38 MARCO, C. DE, 382 MA-~CUS, P. I., 161, 241 MARDER, J. V., 285 MARGOLIASH, E., 309 MARGOLIS, E., 115 MARKERT, C. L., 70 MARKS, P. A., 266, 365, 388, 389,

393, 394, 396, 405,406 MAROTEAUX, P., 110 MARQUIS, J. R., 95 M.~RTENSSON, L., 268,445,449,463

469 MARTI, H. R., 401, 407 MARTIN, C. M., 144 MARTIN, G. M., 240, 253 MARTIN, H., 412 MARTIN, P. H., 105 MARTIN, R. G., 376, 407 MASON, R. J., 86 MASOUREDIS, S. P., 427-428,433-434 MASRI, M. S., 371, 399 MASSIM0, 348 MASTERSON, J. G., 253 MASTROKALOS, M., 419 MATHER, K., 1 MATHEW, N. T., 67 MATIOLI, G., 357, 369

' MATOTH, Y., 116, 120 MATSUDA, G., 299,327, 347, 348, 387 MATSUMOTO, H., 449 MATSUNAGA, E., 53-59, 145 MATTHEI, J. H., 185 MAXWELL, E. S., 185 MAYBERRY, R. H., 95 MAYBURY-LEwIS, D., 69, 87, 92, 95,

127, 435 MAYR, E., 121 MAZIA, D., 242, 248 MEDAWAR, P. B., 3 MEERA KHAN, P., 81 Melanesians, 124 MELICK, R., 61 MELLIN, G. W., 47 MELNYK0VYCH, G., 207, 235 MELTZER, M., 443, 449, 463-472 MENDEL, G., 1, 2 MEMORIA, J. M. P., 72 MERCIER, L.-A., 106 MERMOD, 323 MERRILL, M. H., 186 MERRITT, A. D. 259-260, 271 MERZ, T., 177, 179, 180, 182, 183 Methemoglobin, reduction with

G-6-PD, 262 METTLER, L. E., 177 METZ, C. W., 364 MEYER, K., 120 MI, M. P., 72, 77, 424 Michaelis-Menton relation, 475

MICKLEM, H. S., 462 Micronesians, 124, 133,449 MIESCHER, P., 463 MIGLIORINI, E., 220 MIKKELSEN, W., 94 MIKULSKA, Z. B., 274 MILLER, D. R., 121 MILLER, H. M., 31 MILLER, J. A., 152 MILLER, R., 349 MILLETTE, R. L., 335,344 MINET, P. L., 28 MINNICH, V., 402,408 MIRSKY, A. E., 7, 209,302 MISHELL, n., 460-462 MITAL, M. S., 140 MITCHELL, H. K., 137 MITCHELL, J. S., 152 MITCHISON, N. A., 273 Mitomycins, 476

to break human chromosomes, 179-180, 183

reactivity with mammalian DNA, 155

MIWA, S., 105,213 MIYAJI, T., 300 MIYOSHI, K., 375,382 MOAV, R., 51 Model for population structure, con-

tinuous, 4 MODICA, H., 140 MOIVRE, A. DE, 42 M6LLER, E., 274, 275,277,281 MOLLER, G., 275,279, 281 MOLLICA, F., 404 MOLLISON, P. L., 408 Mongolism, 111,113 Mongoloid birth, effect on fertility,

27 MONOD, J., 3, 200, 201,206, 208, 209,

229,234, 333,346,421 MONTGOMERY, T. L., 402 Mooo, F., 234, 235,237 MOORE, C. V., 402 MOORE, M. M., 403,405 MOORE, R. A., 138 MOORE, S., 218,297-299, 301,302 MOORHEAD, P. S., 192,223,255 MOOR-JANK0WSKI, J. K., 105,455 MORGAN, L. I., 96 MORISHIMA, A., 261,267 MORONI, A., 18, 19, 76 MORRILL, R. L., 75 MORRIS, A. J., 353 Mortality, 41-50

biometric analysis, 45-47 consanguineous marriage and, 48-

49 endogenous and exogenous, 45 genetic component, 47 high, 69 prenatal, perinatal infant, 43-49

MORTON, D., 213 MORTON, J. I., 468 MORTON, N. E., 1, 13, 17, 31-39, 40,

41, 49, 53, 55, 57-59, 69-79, 144,415,424,436,475, 476

Mosaics, human, 251-271,330

MOSSMAN, H. W., 327 MOTULSKY, A. G., 201,206, 213,265,

270, 271, 327-331, 357, 365, 397-413, 415,419, 477

MOURANT, A. E., 19, 60, 71, 94, 115, 140

Mouse fibroblasts in cell cultures, 161-166

MUGARD, H., 239 MUIRHEAD, H~ 327, 329 MULDER, D. W., 133 MULHOLLAND, J., 235 MULLER, C. J., 316,401 MULLER, H. J., 3, 5, 31, 32, 35-37, 41,

49, 69, 72,311 MtJLLER, R., 348 MUNSON, P. L., 208 MURAYAMA, M., 333 Mutagen, 2, 168-171, 174-175, 178-

183 human cells, effect on, 152-154,

159 Mutation, as a cause of diversity, 4 Mutational load ; s e e genetic load, 41 Myeloma, 443-447 MYHRE, B. A., 434 Myoglobin human, 333,375-385

minor components, 375, 378-84 Myoglobinuria, 375, 379,380,382

N NADAS, A. S., 375 NAIMAN, J. L., 391-398 NAKAJIMA, H., 311 NAKAJIMA, O., 311 NAKAZIMA, K., 59 NA-NAKORN, S., 402 NANCE, W. E., 70, 71, 77, 137, 311,

312, 315, 321, 323-326, 364, 406, 407, 409, 415-425, 475, 477, 478

NATHAN, D. G., 220,400,407 NAUGHTON, M. A., 333,347-349, 354,

375 NECHTMAN, C. M., 330 NEEB, H., 316,401 NEEL, J. V., 32, 69, 72, 74, 84, 85-98,

112, 127, 140-142, 146, 201, 291, 329, 347, 358, 360, 365, 368, 403, 404, 406, 407, 435, 436, 475, 476

Negroes, 36, 69-71, 87, 137-149, 322, 324, 335, 387, 388, 393, 394, 402, 403, 405, 408, 423, 435, 446, 449, 450, 472

NENCI, G., 220 NENNA, A., 285 NERRYMAN, C., 444 NEWCOMBE, H. B., 21-30, 32, 78-79,

112, 113,475 New Guinea, 124, 128, 133, 408, 409,

441 NEWHALL, S. M., 404 New Hebrides, 124 NEWMAN, M. T., 90 NEWTON, 111 NEY, R. L., 208

INDEX 489

NICHOL, C. A., 235 NICHOLS, E., 330 NICHOLSON, W. E., 208 NIJENHUIS, L. E., 87 NIRENBERG, M. W., 185 NISONOFF, A., 451 NISWANDER, J., 92, 95 NITOWSKY, H. M., 189, 226, 234, 235,

236,245,256,334,415 NOGI, K., 133 NOLL, H. M., 349 NOVICK, A., 229 NOVITSKY, E., 51, 53, 145 NowIcKI, L., 412 NOYES, W. D., 401 NUSSBAUM, M., 285 NUSSENZWEIG, V., 444 NUZZO, F., 223-231

O O'BRIEN, T. F., 144 OCHOA, S., 187 Ocular albinism, 265,267 ODELL, W. D., 207 OHNO, S., 253,261,267, 271 OKHURA, K., 146 OLD, L. J., 279,462 OLESON, E. B., 141 OLESON, K., 142 OLINS, D. E., 443,453 OLIVER, M., 120 OLOUCH, T., 138 OOMEN, H. A. P. C., 132 OPARA-KUBINSKA, Z., 154 OPITY, J., 270 Orotic aciduria, 189,477 Orotidine-5'-monophosphate

decarboxylase, 190-200 pyrophosphorylase, 190, 191

OSGOOD, E. E., 307 OSHIMA, Y., 382 OSKI, F. A., 105,220 OSSERMAN, E. F., 467,469 Osteogenesis imperfecta congenita,

106 OSTERLAND, C. K., 443,444, 449, 468 OTTELIN, A. M., 408 OUCHTERLONY, 0., 455,459 Overdominance, 4 OYAMA, V. I., 192,207, 246

P PAIN, R. H., 467 PALMER, C. G., 171,267 PAN, J., 209 PAPERMASTER, B., 282, 462 Paraguay, 133-134 PARDEE, A. B., 235, 245 PARK, W. W., 145,267 PARKER, W. C., 201, 213, 322, 415,

420, 436,438 PARKER-WILLIAMS, J., 141 PARKES, A. S., 145 PARKINSON, A. D., 125 P)a~OK, J. G., 140 PARRY, 132 PATPONGPANIJ, N., 408 PAUL, J., 163 PAULING, L., 364,406 PAYNE, R., 285-295

PAYNE, R. A., 333,360 PEARMAIN, G., 453 PEARSON, C. M., 265 PEARSON, H. A., 292,401-405,407 PEARSON, K., 42 PEDREIRA, C., 87 PEIXOTO, L., 87 PENROSE, L., 32, 113 PENTSCHEW, A., 130 PEPLER, W. J., 234 PERKOFF, G. T., 375,380,382,384 PERRIN, D., 201 PERUTZ, M. F., 327, 329 PETERSEN, D., 170, 171 PETERSON, E. A., 451 PETERSON, H. L., 317 PETTENKOFER, H. J., 71,144 Phenotypes, rare recessive, 110,113 Phenylketonuria, 105 PHILLIPS, L. I., 190,191 Phosphatase, alkaline, activity

correlation with karyotype, 226-228

hormonal induction, 234-237 inhibition, 245-248 repression, 240-248 substrate induction, 237-239

conditioned medium, 240 prednisolone, 248 self-induction, 239,240

phosphatase, alkaline, leukocyte, 268

Phosphatase, serum alkaline, 71 PHYHTELA, M., 243 PICKARD, B. M., 392-394 PIEKARSKI, L. J., 162 PIEZ, K. A., 201,207,243,246,248 PIK, C., 407 PINKERTON, P. H., 407 PIOMELLI, S., 408 PISANI, J. F., 32 PISCIOTTA, A. V., 333 PITZUS, F., 409 Plasma thromboplastin deficiency,

106 Plasma uric acid, 94, 95 Pleiotropy, 61-68,475

G-6-PD deficiency and body height, 418,419,423

POLIVANOV, S., 4 POLMAR, S., 449,451,452, 453 Polygenes, 2, 5, 68, 72-79,111-112 Polymorphism

factors influencing, 61 group-specific component, 435-437 haptoglobin, 435 hemoglobin, 137-150,475,476 in man, 61-68, 418, 419, 423, 435,

475, 478 Jews, non-Ashkenazim, 115 selection, 69,137, 149 thalassemia, 407-409 transient, 6 zygotic selection, 59,145, 146

Polynesians, 124 PONTECORVO, G., 201, 207, 223, 229,

233,237,239,240,276 POPP, R. A., 278

Population fitness, 52 size, 5, 17 structure, 14, 74-77,476 studies, 475

computer programs for, 27-29 Gc frequencies, 435-437 haptoglobin frequencies, 435 sickle trait, 137-149 thalassemia, 407-409

Populations association of genetic traits in,

137-149, 286,287 civilized, 121 genetic diversity, 4 Gm factor, 445, 446 haptoglobin types in, 322-326 inbred, 81-84, 93, 108-113, 115-

120, 128-134 mortality, 41-50, 69 polymorphism in, 137-149 selection in cell, 253-260 selection in human, 137-149

PORTER, I. H., 392-394,415,420 PORTER, R. R., 443,451,452,467 POST, R. H., 149 POTTER, E. L:, 43 POULIK, M. D., 327,392,443,467 POURFAR, M., 228 PRANKERD, T. A. J., 213,382 PREHN, R. W., 279 PRESS, E. M., 443 PRESTIDGE, L. S., 236 PRIOR, A. M., 58 PROCOPIO, F., 105,220 PROKOFJEVA-BELGOVSKAJA, A. A.,

311 Proteins

human, 478-480; s e e a l s o Pence- Jones, group-specific compo- nent, haptoglobin, hemoglo- bin, myoglobin

myeloma, 443,445-447,469,472 urinary, 469

Protonopia ; s e e color blindness PRUNIER, J. H., 439 PTCN goiter, 71, 72 PUCK, T. T., 161, 167-176, 178, 183,

192, 223, 241, 242, 476, 477 PUNT, K., 361,365,401,405 Puromycin, 181,476 PUTNAM, F. W., 317, 444 PUXEDDU, A., 220 Pyruvate kinase, 213-221

ATP production, 213 chemical structure, 220 exception to separate control, 220 genotype related to RBC, 213,214 RBC and WBC compared, 214-219

Pyruvate kinase deficient hemolytic anemia; s e e anemia

Q QUATTRIN, 348 QUELCE-SALGADO, A., 32, 36

R RACE, R. R., 253,286,292,415,455 Racial mixture, 73, 74 RADDING, C. M., 209

490 INDEX

Radiation induction of mutation, 2

RAFTERY, M. A., 297, 301,302 RAGNI, G., 151, 155, 157,161 RAMIREZ, J. R., 327 RAMOT, B., 116, 375,402,408 RANDALL, R. J., 193 RANDALL', R. V., 248 RANNEY, H. M., 402,403 RAPER, A. B., 138, 139,140,359 RAPPAPORT, S., 120 RASMUSSON, M., 435 RATNOEF, O. D., 105 Records available of

abnormalities, 24 blood groups, 24 childhood death, 22-29 crime, 24 deaths, 23 handicapped children, 22-29 livebirths, 22-29 marriages, 22-29 multiple births, 22-29 parents, 22-29 physiques of fathers, 24 school performance, 24 stillbirths, 22-29

REED, T. E., 53, 60, 68, 143, 145,265, 271

REINSKOU, T., 439 Rzis, R. H., 32, 72 REISMAN, L. E., 253 Renal tubular defect, 106 RENKONEN, K. O., 146 Rennell Islands, 124 RENWICK, J., 236,276 REYNAFARJE, B., 375 REYNARD, A. M., 213,216 REYNOLDS, W. E., 94 RHOADES, M. M., 51 RHYNAS, P. O. W., 27, 28 RICH, A., 334,339,349,352 RICHARDSON, S. N., 347, 399 RICHTER, G. W., 233 RICHTERICH, R., 220 Rickets, 266 RIEDER, R. F., 335,338 RIESENBERG, S., 123,124 RIFKIND, R. A., 389 RIGAS, D. A., 213-221,336,365,402 RIGGS, A., 327 RILEY, H. D., 394,395 RIVAT, L., 70, 86, 443, 445, 450, 463,

470 RIVERS, S. L., 189 RIVLIN, R. S., 208 RNA

mutations at level of, 158, 159 synthesis and inactive

X-chromosome, 266 ROBERTS, D. F., 122 ROBERTS, E., 263 ROBERTS, J. A. FRASER, 111,143 ROBERTS, R. W., 96 ROBINSON, A., 175, 178,192 RORINSOI% A. R., 142,400,403 ROBINSON, D. D., 141 ROBSON, E. B., 312, 323, 324

ROCHE, J., 358,360 ROCHLIN, D. G., 106 ROLFS, M. R., 285 ROMER, 1VL A., 407 ROMIG, R., 185 RONDLE, C. J. M., 71 RONEN, A., 115, 118 RONEN, I., 115,118 ROOD, J. J. VAN, 285, 286, 288, 291,

293, 478 ROOSA, R. A., 161 ROPARTZ, C., 70, 443, 445, 450, 463,

470 ROSE, B. S., 94 ROSEBROUGH, N. J., 193 ROSEN, F., 235 ROSENBERG, J. C., 179 ROSENBERG, S. A., 177, 179 ROSENBLAT, A., 96 ROSENFIELD, R. E., 70, 77, 424, 427-

434, 478 ROSENTHAL, I. M., 393,394 ROSEVEAR, J. W., 248 ROSIN, S., 105 ROSLANSKY, J. D., 327 Ross, J. D., 217 RossI, 105 RossI, E., 263 ROSSI-FANELLI, A., 354,382 ROTHMAN, F., 229 ROUILLARD, L. M., 178 ROUSE, I., 86 ROUSSEAU, P. Y., 70, 445, 450,470 ROWLEY, 399 ROWLEY, D., 144 ROYER, P., 110 RUANGURT, U., 108 RUBENSTEIN, H. M., 403 RUBIN, H., 280 RUCKNAGEL, D. L., 140,333,360,402,

403 RUDLOFF, V., 348 RUINARD, J., 135 RUNDLES, R. W., 265 RUSHTON, W. A. H., 266 RUSSELL, A. V., 285 RUSSELL, L. B., 253,266, 462 RUSSELL, W. L., 181 Russo, G., 404 RYAN, F. J., 223

S SACHS, L., 164 SACKS, M. S., 124 SAGER, R., 185 SAIJO, K., 382 ST. HELEN, D., 307 ST. RAYMOND, M. L., 404 SAKSELA, E., 234 SALITERNIK, R., 120 SALMON, CH., 253, 285 SALZANO, F. M., 32, 69, 85-98, 127,

435, 476 Samoa, 125 SANDANHA, P. H., 70 SANDER, E. M., 185 SANDERS, P., 170, 171 SANDLER, I., 51 SANDLER, L., 51, 52

SANGER, R., 253, 265, 266, 286, 292, 455

SANGHVI, L. D., 7, 41, 68, 81 SANSONE, G., 263 SANTESSON, B., 253 SARIN, E., 234 SARKAR, P. F., 165 SARKAR, P. S., 163,164 SARLES, H., 404 SAVART, P., 110 SCARO, J. L., 335, 344 SCHAAD, J. D. G., 365,405 SCHACHT, L. E., 436 SCHADE, A. L., 144 SCHADE, R., 217 SCHAFFNER, A., 245 SCHARIKOVA, A., 245 SCHECHTER, A. N,, 185 SCHEIDEGGER, J. J., 455 SCHELL, S. B., 363 SCHETTINI, F., 392-394 SCHLESSINGER, D., 389 SCHMIDT, R., 120 SCHMIDT, P. J., 466 SCHNEEBERGER, IV~., 105 SCHNEIDER, D. M., 134 SCHNEIDER, R. G., 333,404 SCHNEIDERMANN, L. J., 382 SCHNEK, A. G., 302, 336 SCHOFIELD, F. D., 125 SHREFFLER, D., 462 SCHRIER, S., 419 SCHROEDER, E. A., 213 SCHROEDER, W. A., 297-302, 304,305,

327, 336,387 SCHULL, W. J., 32, 38, 72, 73, 84, 86,

146, 291 SCHULZE, J., 415,420 SCHWARTZ, H. C., 363,404 SCHWARTZ, I. R., 363,402 SCHWARTZ, K., 130 SCHWARTZENBACH, G., 246 SCHWEET, R., 339, 349 Sclerosis, amyotrophic lateral, 133 SCOGGINS, R. B., 189 SCOTT, a. 1~., 217 Scrapie in sheep, 132 SCUDO, F., 15 SEBAQ, J., 133 SEEGMILLER, 191 Segregation-distorter (SD), 51 Segregation of mutants in cell lines,

165 Segregational load, 475;

s e e Genetic load SEITELBERGER, F., 130 Selection

blood groups, 71,143-145 diversifying, 4, 6,475 directional, 6 heterotic, 4 sex ratio, 145 small pox, 71

Selection, cell, 151,161-163, 261,267 in G-6-PD deficient and normal,

254-259 in mosaics, 59, 60,253-260 in tumor, 256, 257, 276-83

INDEX 491

Selection, cell (cont'd) prezygotic, 51-60

blood groups (ABO, MN, P), 53-58

drive, 51 genetic load, 51-53 polymorphism, 50, 59

postzygotic, 51 SELWYN, J. G., 213 SEMPLE, N. M., 94 SETLOW, R., 154 SHAHANI, S., 144 SHAPmO, S., 47 SHARMA, R. S., 140 SHARON, N., 349 SHAW, M. W., 174, 193 SHEBA, CH., 116, 120, 149, 402, 415 SHEETS, R. F., 399 SHELTON, J. B., 301,304 SHELTON, J. R., 301,304 SHEPARD, M. K., 347, 399 SHEPPARD, P. M., 71 SHIBATA, S., 300 SHIELDS, G. S., 360 SHIMIZU, N., 208 SHOOTER, E. M., 369, 387, 401 SHOPE, R., 94 SHREFFLER, 93 SHUKLA, R. N., 140 SHULMAN, N. R., 285,292 SIDEL, V. W., 220 SIEVERS, M. L., 95 SIGNER, E. R., 185 SILBER, R., 427,428,434 SILLEN, R. G., 246 SILVESTRONI, E., 348, 359,363 SIMMONS, R. T., 94,123,124 SIMOES, I. A., 32 SIMON, E., 250 SIMON, E. R., 393,394 SIMPSON, P. J., 171 SINGER, K., 358, 360-361, 363, 368,

371,374-375,387,399,403-404 SINGER, L., 371,399,403 SINGER, S. J., 364 SINISCALCO, !~I., 323, 399, 408, 409,

415, 420 SJbGREN, H. 0., 273,279,280, 281 SLATIS, H. M., 31, 32, 61-68, 72, 73,

79,149,475,476 SLIZYNSKA, H., 310 SLOBODY, L., 106 SLUMP, P., 132 Smallpox, 71 SMELLIE, R. M. S., 163 SMITH, C. A. B., 418 SMITH, C. H., 99 SMITH, E. L., 309 SMITH, G. M., 402 SMITH, L. H., 190, 191,193,199, 200,

206,209 SMITH, M. J., 151,155 SMITH, S. M., 420 SMITHIES, 0., 70, 71, 77, 157, 309-

319, 321, 324-326, 355, 380, 384, 387, 406, 424, 435, 437, 438, 479

SNELL, G. D., 273,274, 277, 283,455

SOBER, H. A., 451 SONNEBORN, T. M., 7, 159 SPACKMAN, D. H., 297-299,302 SPADA, U., 408 SPASSKY, B., 3, 33 SPIESS, E. B., 3 SPILLER, W. G., 106 SOFFRITTI, E., 348 SOLANKI, B. R., 140 SOLOMON, J. M., 427 SORIEUL, S., 164,223,224 SORRENTI, A. M., 140 SORSBY, A., 265 SOUTHAM, A. L., 144 SPAET, T. H., 285 Spain, 133 SPARKES, R. S., 267 Spastic paraplegia, 106 SPEYER, J. F., 185 SPOON, W., 132 SPRINGER, G. F., 71 SPUHLER, J. N., 82, 121 SRINGAM, S., 409 STACEY, S. M., 253 STAEHELIN, T., 349 STALKER, H. D., 51 STAMATOYANNOPOULOS, G., 142, 143,

367, 399-401,403,407,409 STANLEY, L. L., 228 STANLEY, W. M., 470 STANWORTH, D. R., 443,449,467 STAUFFER, R., 449 STEFFEN, J., 167, 169, 174 STEIN, W. H., 218, 297-299, 301,302 STEINBERG, A., 70, 124, 322, 424, 443,

446, 447, 449-454, 455, 461, 470, 472, 479

STEINER, M., 405 STENT, G. S., 315,346,406,407,421 Stepping-stone model for population

structure, 14 STERN, C., 64 STEUERMANN, N., 94 STEVENS, B. L., 401 STEVENS, L. C., 273,277 STEVENS, W. L., 181 STEWARD, J. H., 91, 96 STEWART, T. D., 86 STIEHM, E. R., 463-472 STIJNS, J., 137 Stillbirth, 43

fertility increase following, 26, 27 records available of, 22-29

STIMPFLING, ,1. H., 274, 278,283,455 STOKER, M., 279 STONE, W. H., 253 STOSS, B., 71 STRANSKY, E., 408 STRASSLE, R., 463 Streptonigrin, and mammalian

cells, 174, 175 STRETTON, A. O. W., 301, 302, 304,

306, 347, 363, 365, 401, 406 STULBERG, C. S., 151 STURGEON, PH., 358, 360, 361, 368,

4O5 STURTEVANT, A. H., 51,311 STUTTS, P., 161

SUGIURA, Y., 106 SUINGDAMRONG, A., 402 SUKUMARAN, P. K., 140 SULLIVAN, M., 190,191,193,199 SUNDARAGIATI, B., 143,410 SUNDELL, G., 145 SUTTER, J., 41-50, 72, 73,475 SUTTON, H. E., 142, 322, 325, 346,

425, 447 SUVATEE, V., 402 SWANSON, C. P,, 180 SWENSON, R. T., 333 SWISHER, S. N., 427 SYDENSTRYCKER, V. P., 359-361,363 Symphalangism, 106 SZABO, M. A., 116 SZEINBERG, A., 116, 120,392,393 SZENTIVANYI, A., 458 SZER, 187 SZYBALSKA, E. H., 151,152, 155-157,

159, 161,163 SZYBALSKI, W., 151-159, 161, 163,

164,211,476 SZYMANSKI, I. 0., 427-434

T TABAH, L., 42, 44, 49 TAFT, H. P., 61 TAKATSUKI, K., 467,469 TAKEDA, I., 300. TAKEMURA, T., 311 TALMAGE, D. W., 391,458 TAMURA, A., 300 TANAKA, K. R., 105, 146, 213, 214,

269 TARLOV, A. R., 394,419 TASHJIAN, A. H., 208 TASHIAN, 93 TAUSSIG, F. J., 48 TASSOPOULOS, N., 398 TAVENDALE, O. G., 26 TAYLOR, E., 163 TAYLOR, G. L., 58 TAYLOR, J. H., 261,267, 319 TEN BROEK, C., 186 TERASIMA, T., 171,173 TERRY, W. D., 444,445 Thais, 408, 409 Thalassemia, 115, 117, 314, 315, 347,

359-363,365-374,389,399-414 alpha and beta, 399-402 and G-6-PD deficiency, 408-409 definition of, 399 distribution, geographical, 407-

409 genetics of, 402-404 interaction with HbS and HbC,

401 F-thalassemia, 404, 405, 407 mechanism of heme synthesis, 405

THEIL, G. B., 375 THEODOR, E., 116 THEORELL, H., 382 THOMAS, J. D., 105 THOMAS, L., 247 THOMPSON, G. R., 138, 139 THOMPSON, J. S., 253 THOMPSON, P., 213-221 THOMPSON, R. B., 330

492 INDEX

THORPE, N. O., 468,469 Thymidine

and growth of mammalian cells, 171-173

Thymidine analogs reactivity with DNA, 155

TICK, S. C., 311 TIDWELL, T., 33 TIERNEY, J. H., 234,239,253 TIETZE, C., 145 TIMMS, G., 138 TINDALE, N. B., 124 TIPPETT, P., 415 TOCANTINS, L. M., 363,402 TODD, C. W., 461 TOLMACH, L. J., 171,173 TOMPKINS, G. M., 195,209 Tongariki, 124 T~NZ, O., 263 TORRES, J., 133 TORRIANI, A., 240 Transformation antigens, 273-283 Transformations, genetic

induced in cell lines, 152-154 spontaneous in cell lines,

151-153 TRAUTNER, T. A., 185 TRIER, J. S., 214 TRIPP, J., 462 TRIPP, M., 285-295 Trisomy, 21,330

D-, 206,330,331 E-, 330 effect of, 206

TROBAUGH, F. E., 394 TROTTER, W. R., 71 TRUJILLO, J., 267 TRVOG, G., 105 TSEVRENIS, H., 402 TSUGITA, A., 185,470 Tuberculosis, 84, 95 TUCHINDA, S., 402,403, 405,406,408 TURNER, J. H., 267 Turner's syndrome, 111-113 TURPIN, R., 146, 253 Twins, 253 TYLER, F. H., 380

U UCHIDA, I., 415 UEMURA, M., 94 UMANSKY, I., 323 Uridine biosynthesis, 189-212

and chromosome dose, 207 UV light

effect on mammalian DNA, 154, 155

V VALAES, T., 398,419 VALENTINE, W. N., 105, 213, 214,

219, 220, 235 VANBELLINGHEN, P., 213-221 VANDEPITTE, J., 137, 139,140 VAN RYSEWIJK, M. G. n., 143 VAREENIL, C., 408 Variability

prezygotic selection, 51-60 VAUGHN, J. H., 463 V~LEZ, C., 106

VELLA, F., 365,402 VENCOWSKI, R., 38 VENTRUTO, 348 VERLOOP, M. C., 401 VIETTI, T., 394 VINCENT, P., 43 VOGEL, F., 71,144, 209 VOGT, M., 280 Vos, G. H., 449 Vos, O., 173 Voss, R., 120

W WAARDENBURG, P. J., 265,267 WADMAN, S. K., 375 WAELSCH, SALOME G., 159 WAGNER, R. P., 137 Wahlund's principle, 76-77 WAJNTAL, A., 137 WALD, N., 267 WALDSCHMIDT-LEITZ, E., 245 WALFORD, R. L., 285 WALKER, N. F., 321 WALL, 105 WALLACE, B., 3 WALLER, H. D., 220,369 WALTERS, J. H., 138 WALTERSDORPH, A. M., 214 WARNER, J. R., 334, 339, 349-350,

353 WARNER, N. L., 462 WARREN, A. K., 171 WARTSKI, S., 116 WASHBURN, S. L., 121 WASI, P., 402 WELLS, W. H. C., 402 WATANABE, Y., 240 WATSON, E. M., 245 WATSON, J. D., 312 WATSON-WILLIAMS, G. J., 137, 140,

141,392,403 WATTEN, R. H., 375 WAXMAN, S. H., 253 WAYMOUTH, C., 237, 240-244,248 WEATHERALL, D. J., 137, 141, 347,

387-388, 399, 401, 403, 405, 4O8

WECKSTROM, P., 243 WEIGLE, J., 285-295 WEILBACHER, R. G., 392,394,415 WEILER, R. J., 458 WEIL-MALHERBE, H., 217 WEINBERG, A. S., 183, 189, 191,192 WEINSTEIN, E. D., 92, 94 WEINSTEIN, I. B., 185,187 WEINSTEIN, I. M., 391 WEISBLUM, B., 334,354,421 WEISS, G., 299,300 WEISS, G. H., 14, 75 WEISSMAN, S. M., 163 WEHKY, N., 327 WELLS, I. C., 364 WENT, L. N., 141 WESTRING, D., 394 WETTSTEIN, F. O., 349 WHEELER, J. T., 333,347,402 WHITE, C. B., 124 WHITE, J. C., 401 WHITEHOUSE, H. L. K., 312, 316

WHITMORE, S. J., 165 WHORTON, C. M., 375,382 WIERNER, A. S., 71 WILBERT, J., 87, 90 WILLIAMS, E. D., 207 WILLIAMS, H. L., 245 WILLIS, R. A., 234 WILSON, C., 201,206 WILSON, J. A., 70, 443, 446, 449,

450,454,470 WINTERHALTER, K. H., 355,405 WINTROBE, M. M., 358,405 WISI-IART, P. J., 87 WISSLER, F. C., 451 WITTMANN, H. G., 185 WOERNLEY, D. L., 451 WOLF, C. DE, 140 WOLFF, J. A., 400,402 WOODS, P. S., 317 WOOLF, B., 138, 139 WORKMAN, P. L., 74, 140 WORKMAN, W. G., 466 WORMINGTON, H. M., 86 WORNER, W., 412 WORTIS, H. H., 455,462 WRIGHT, C.-S., 105 WRIGHT, S., 1, 6, 14, 15, 39, 49, 50,

74, 76, 91,121,122,311 WUNDERLICH, J., 455,460 WYCKOFF, M. M., 451 WYMAN, J., 354

X XEFTERI, E., 402 XEROS, N., 171 X rays

chromosome breakage, 178, 180- 182

growth of mammalian cells, 173, 174

mammalian DNA, 154-155 mutation of human cells, 179

Y YAKULIS, V. J., 334 YAMAOKA, K., 311 YANOFSKY, C., 164, 185,313,470 YASUDA, N., 75-77, 424 YEE, W., 424 YEH, M., 253,415 YERUSHALMY, J., 43, 44, 69 YOUNG, W. J., 177, 182,470

Z ZANNOS, L., 368 ZANNOS-MARIOLEA, 399 LET, G., 19 ZELENY, C., 311 LEMAN, 259 ZIGAS, V., 124 ZILLIACUS, H., 408 ZINDER, N. D., 443,453 ZINKHAM, W. H., 335,338 ZIwo, R., 354 ZLOTNIKOFF, W., 270,477 ZONTA, L., 19 ZUCKERKANDL , E., 330, 347, 357-

374,388,406, 407, 461,479 ZUCKERMAN, A. J., 143,144 ZUELZER, W. W., 141, 142, 253, 360,

400, 403