INDEX OF ORGANIZING COMMITTEE, CHAIRMEN, SPEAKERS, SPECIAL DISCUSSANTS, AND PARTICIPANTS

ABBONDANDOLO, A., Istituto Nazionale per la Ricerca suI Cancro, Genova, Italy

ALLEN, JAMES, U.S. Environmental Protection Agency, Research Triangle Park, NC

ALVAREZ, MARVIN R., University of Southern Florida, Tampa, FL ANDERSON, ELIZABETH, U.S. Environmental Protection Agency, Washington, D.C. ASHLEY, TERRY, University of Tennessee, Knoxville, TN ATHWAL, RAGHBIR S., New Jersey Medical School, Newark, NJ AVIVI, LYDIA, Tel-Aviv University, Rehovot, Israel AZIZ, M. ASHRAF, Howard University College of Medicine, Washington, D.C.

BACKER, LORRAINE C., U.S. Environmental Protection Agency, Research Triangle Park, NC

BADER, PATRICIA I., Northeast Indiana Genetic Counseling Center, Parkview Memorial Hospital, Fort Wayne, IN

BARNHART, BENJAMIN J., Office of Health and Environmental Research, U.S. Department of Energy, Washington, D.C.

BARRETT, J. CARL, National Institute of Environmental Health Sciences, Research Triangle Park, NC

BECKETT, TERESA, The University of Calgary, Alberta Children's Hospital, Calgary, Alberta, Canada

BECKING, GEORGE C., World Health Organization at National Institute of Environmental Health Sciences, Research Triangle Park, NC

BELL, EDWIN L., Albright College, Reading, PA BELL, SANDRA, University of Tennessee, Knoxville, TN BERNSTEIN, RENEE, South African Institute for Medical Research,

Johannesburg, South Africa BIDDLE, FRED G., The University of Calgary, Alberta Children's Hospital,

Calgary, Alberta, Canada BLOOM, KERRY, University of North Carolina, Chapel Hill, NC BOND, D. JEFFREY, University of Edinburgh, Edinburgh, Scotland BOOTHROYD, E.R., McGill University, Montreal, Quebec, Canada BRANDRIFF, BRIGITTE F., Lawrence Livermore National Laboratory, Livermore,

CA BRINKLEY, B.R., University of Alabama at Birmingham, Birmingham, AL BUSS, EDWARD G. Pennsylvania State University, University Park, PA

CARERE, ANGELO, Istituto Superiore di Sanita, Rome, Italy CAVAGNARO, JOY, Hazleton Biotechnologies Corporation, Vienna, VA CHAMBERS, CAROLYN, University of Pennsylvania, Philadelphia, PA CHANDLEY, ANN C., Medical Research Council, Western General Hospital,

Edinburgh, Scotland CHERNOS, JUDY E., The University of Calgary, Alberta Children's Hospital,

Calgary, Alberta, Canada CHERRY, LORRAINE M., University of Texas, M.D. Anderson Hospital, Houston,

TX CHOY, WAI NANG, E.I. DuPont de Nemours & Co., Inc., Newark, DE

549

CHRISTIE, NELWYN T., University of Texas, M.D. Anderson Hospital, Houston, TX

CIMINO, MICHAEL, U.S. Environmental Protection Agency, Washington, D.C. CLEGG, ERIC, U.S. Environmental Protection Agency, Washington, D.C. CLIVE, DONALD, Burroughs Wellcome Company, Research Triangle Park, NC COMLEY, SARAH H., Washington, D.C. CONLEY, RONALD W., Administration on Developmental Disabilities, Department

of Health and Human Services, Washington, D.C. COOPER, JANE E., Pennsylvania State University, University Park, PA CORTINA, THOMAS, Hazleton Biotechnologies, Inc., Vienna, VA COSTA, MAX, Houston, TX CUMMINGS, MICHAEL R., University of Illinois at Chicago, Chicago, IL CZERSKI, PRZEMYSLAW, Washington, D.C.

DAGNA BRICARELLI, FRANCA, Centro Regionale Genetica Umana, Genova, Italy DAVIS, DAVID GALE, University of Alabama, Tuscaloosa, AL DAVISSON, MURIEL T., The Jackson Laboratory, Bar Harbor, ME DEARFIELD, KERRY, U.S. Environmental Protection Agency, Washington, D.C. DE BRABANDER, MARC, Janssen Pharmaceutical Research Laboratory, Beerse,

Belgium DE CARLI, LUIGI, University of Pavia, Pavia, Italy DEGRASSI, FRANCESCA, Centro Genetica Evoluzionistica/National Research

Council, Rome, Italy DELLARCO, VICKI L., U.S. Environmental Protection Agency, Washington, D.C. DE SERRES, CHRISTINE M., University of North Carolina, Chapel Hill, NC DE SERRES, FREDERICK, National Institute of Environmental Health Sciences,

Research Triangle Park, NC DEV, V.G., Vanderbilt University, Nashville, TN DEWEESE, GARY KENNETH, Duke University Medical Center, Durham, NC DIGGANS, GERARD R., Magee Womens Hospital, Pittsburgh, PA DIXON, MARTHA, York University, Downsview, Ontario, Canada DOERR, CAROLYN, Environmental Health Research and Testing, Raleigh, NC DOOLITTLE, DAVID J., Rohm and Haas Company, Spring House, PA DRESSER, MICHAEL E., Duke University Medical Center, Durham, NC DREWS, DIANNA, The University of Calgary, Alberta Children's Hospital,

Calgary, Alberta, Canada

EALES, BRENDA A., The University of Calgary, Alberta Children's Hospital, Calgary, Alberta, Canada

EBERT, JAMES, Carnegie Institution of Washington, D.C., Washington, D.C. EDEL, C.K., Queens College, Flushing, NY EDEL, M.D., Queens College, Flushing, NY EGOZCUE, J., Universitat Autbnoma de Barcelona, Barcelona, Spain ELDER, FREDERICK, The University of Texas Medical Branch, Galveston, TX ELLIS, J.F., Hamilton College, Clinton, NY EVANS, H.J., Western General Hospital, Edinburgh, Scotland

FARBER, ROSANN A., The University of Chicago, Chicago, IL FARLAND, WILLIAM, U.S. Environmental Protection Agency, Washington, D.C. FELDMAN, MOSHE, The Weizmann Institute of Science, Rehovot, Israel FIBISON, WENDY J., University of Pennsylvania, Philadelphia, PA FINLEY, WAYNE H., University of Alabama at Birmingham, Birmingham, AL FOGEL, SEYMOUR, University of California, Berkeley, CA FORD, JUDITH H., The Queen Elizabeth Hospital, Woodville, South Australia,

Australia FORSMAN, IRENE, Health Resources and Services Administration, Rockville, MD FOWLE, Jack, U.S. Environmental Protection Agency, Washington, D.C. FUSSELL, CATHARINE P., Pennsylvania State University--Ogontz, Abington, PA

GALLOWAY, SHEILA M., Merck Institute for Therapeutic Research, West Point, PA

550

GAULDEN, MARY ESTHER, University of Texas Health Sciences Center, Dallas, TX

GEARHART, JOHN D., Johns Hopkins University, Baltimore, MD GENEROSO, W.M., Oak Ridge National Laboratory, Oak Ridge, TN GIBSON, JAMES B., Duke University Medical Center, Durham, NC GILES, RICHARD E., Advanced Genetics Research Institute, Oakland, CA GOLDEN, W.L., Case Western Reserve University, Cleveland, OH GOLDSTEIN, BERNARD, U.S. Environmental Protection Agency, Washington, D.C. GOLLIN, SUSANNE M., University of Arkansas, Arkansas Children's Hospital,

Little Rock, AR GRANITE, MARY LOU OSTER, Johns Hopkins University, Baltimore, MD GREEN, M.M., University of California, Davis, CA GRELL, RHODA, Oak Ridge National Laboratory, Oak Ridge, TN GRIFFIN, MARGARET 0., Fordham University, Yonkers, NY GRIFFITHS, A.J.F., University of British Columbia, Vancouver, British

Columbia, Canada

HAGLUND, ULLA, AB Astra, Toxicology Laboratories, S6dertalje, Sweden HARM, SUE, Albert Einstein College of Medicine, New York, NY HANSMANN, INGO, Universitat GBttingen, G6ttingen, Federal Republic of

Germany HASSOLD, TERRY JON, University of Hawaii, Honolulu, HI HEARTLEIN, MICHAEL W., Harvard Medical School, The Children's Hospital,

Boston, MA HENRICH, RICHARD T., Dow Corning Corporation, Midland, MI HILL, RICHARD, U.S. Environmental Protection Agency, Washington, D.C. HOFFMANN, GEORGE, Holy Cross College, Worchester, MA HOLDEN, HENRY E., Pfizer Central Research, Groton, CT HOLLAENDER, ALEXANDER, Council for Research Planning in Biological Sci-

ences, Inc., Washington, D.C. HOOK, E.B., New York State Department of Health, Albany, NY HSU, T.C., University of Texas, M.D. Anderson Hospital, Houston, TX HUANG, ANN, U.S. Environmental Protection Agency, Washington, D.C. HUETHER, CARL A., University of Cincinnati, Cincinnati, OH HULTEN, MAJ, East Birmingham Hospital, Birmingham, United Kingdom

IMMKEN, LADONNA, University of Texas Medical School, Houston, TX IVETT, JAMES L., Litton Bionetics, Kensington, MD JABS, ETHYLIN, Johns Hopkins University, Baltimore, MD JACKSON-COOK, COLLEEN, Virginia Commonwealth University, Richmond, VA JACOBSON, CECIL B., Reproductive Genetics Center, Vienna, VA JENKINS, EDMUND C., Institute for Basic Research in D.D., Staten Island, NY JOHNSON, WALTER E., Case Western Reserve University, Cleveland, OH JUBERG, RICHARD C., Wright State University, Dayton, OH

KAFER, ETTA, McGill University, Montreal, Quebec, Canada KAO, YUAN S., Louisiana State University Medical Center, New Orleans, LA KAPPAS, ANDREAS, Nuclear Research Center "Democritus," Athens, Greece KERMAN, SHELLY L., American Medical Laboratories, Fairfax, VA KIMBERLING, WILLIAM J., Boys Town National Institute, Omaha, NE KIMMEL, CAROLE, U.S. Environmental Protection Agency, Washington, D.C. KIMMEL, GARY, U.S. Environmental Protection Agency, Washington, D.C. KLINE, JENNIE, New York State Psychiatric Institute, New York, NY KOZMA, CHAHIRA C., Georgetown University Hospital, Washington, D.C. KRAM, DAVID, U.S. Environmental Protection Agency, Washington, D.C. KUNY, GREGORY, Council for Research Planning in Biological Sciences, Inc.,

Washington, D.C. KUZAVA, JAN, Georgetown University Hospital, Washington, D.C.

LABIDI, FATMA, University of Connecticut School of Medicine, Farmington, CT

551

LASNE, CLAUDE, Institut de Recherches Scientifiques sur Ie Cancer, Ville-juif-Cedex, France

LAVAPPA, K.S., U.S. Food and Drug Administration, Washington, D.C. LEVITAN, MAX, Mt. Sinai School of Medicine, New York, NY LI, LUYUN, Hunan Medical College, Hunan, People's Republic of China LIANG, JAN, University of Texas, M.D. Anderson Hospital, Houston, TX LINNAINMAA, KAIJA, National Cancer Institute, Bethesda, MD LOVEDAY, KENNETH S., Bioassay Systems Corporation, Woburn, MA

MAGNI, G.E., Dipartimento di Biologia Sez. Genetica e Microbiologia, Milan, Italy

MAILHES, JOHN B., Louisiana State University Medical Center, Shreveport, LA MAJESKA, JENNESS, Stauffer Chemical Company, Farmington, CT MAPP, PAULETTE, Fordham University, Yonkers, NY MARTIN, RENEE H., Alberta Children's Hospital, Calgary, Alberta, Canada MASON, JAMES M., National Institute of Environmental Health Sciences,

Research Triangle Park, NC MAUER, IRVING, U.S. Environmental Protection Agency, Washington, D.C. MAVOURNIN, KATHLEEN H., Environmental Mutagen, Carcinogen, and Teratogen

Information Program, Oak Ridge National Laboratory, Oak Ridge, TN MAYER, VERNON, Food and Drug Administration, Washington, D.C. MCDONOUGH, PAUL G., Medical College of Georgia, Augusta, GA MCINTOSH, J. RICHARD, University of Colorado, Boulder, CO MIGEON, BARBARA R., Johns Hopkins University, Baltimore, MD MILLER, ROBERT B., American Medical Laboratories, Inc., Fairfax, VA MOENS, PETER B., York University, Downsview, Ontario, Canada MOORE, JAY W., John F. Kennedy Institute, Johns Hopkins University,

Baltimore, MD MOORE, MARTHA, U.S. Environmental Protection Agency, Research Triangle

Park, NC MORELAND, F.M., Food and Drug Administration, Washington, D.C. MORISHlMA, AKlRA, Columbia University Babies Hospital, New York, NY MOSES, MONTROSE J., Duke University Medical Center, Durham, NC MUDRICK, MICHAEL A., Georgetown University Hospital, Washington, D.C. MYHR, BRIAN C., Litton Bionetics, Inc., Kensington, MD

NASH, HESED PADILLA, H & W Cytogenetic Services, Inc., Sterling, VA NASH, WILLIAM G., H & W Cytogenetic Services, Inc., Sterling, VA NICKI.AS, BRUCE, Duke University, Durham, NC NITISS, JOHN L., National Institute of Environmental Health Sciences,

Research Triangle Park, NC NITOWSKY, HAROLD M., Albert Einstein College of Medicine, New York, NY

OLSON, SUSAN BENNETT, Oregon Health Sciences University, Portland, OR ONFELT, AGNETA, University of Stockholm, Stockholm, Sweden OSHlMURA, MITSUO, National Institute of Environmental Health Sciences,

Research Triangle Park, NC OSTROWSKY, JULIE, Office of Technology Assessment, U.S. Congress,

Washington, D.C. OVERTON, LAURIE K., SRI International, Menlo Park, CA

PAl, G.S., Medical University of South Carolina, Charleston, SC PALITTI, FABRIZIO, Centro di Genetica Evoluzionistica del CNR,

UniversitA di Roma, Roma, Italy PARKER, DAVID L., Georgetown University Hospital, Washington, D.C. PATIL, SHIVANAND R., University of Iowa Hospitals and Clinics,

Iowa City, IA PETERS, G.B., Queen Elizabeth Hospital, Woodville, South Australia,

Australia PHELAN, M.C., Greenwood Genetic Center, Greenwood, SC PHELPS, WARNER, CIBA-GEIGY Corporation, Greensboro, NC

552

POTLORI, VENKATESWARA RAO, Mount Sinai Medical Center, New York, NY PUESCHEL, SEIGFRIED M., Rhode Island Hospital, Brown University, Provi­

dence, RI

REICHMANN, AMELIA, University of South Alabama, Mobile, AL RESNICK, MICHAEL, National Institute of Environmental Health Sciences,

Research Triangle Park, NC RICHARDSON, CHRISTOPHER R., Central Toxicology Lab, Cheshire, United

Kingdom RISLEY, MICHAEL S., Cornell University Medical College, New York, NY ROBINSON, ARTHUR, National Jewish Hospital and Research Center, Denver, CO ROBINSON, L. PAT, Georgetown University Hospital, Washington, D.C. ROCHON, MARCEL, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke,

Quebec, Canada RODERICK, THOMAS H., The Jackson Laboratory, Bar Harbor, ME ROSENTHAL, SHEILA, U.S. Environmental Protection Agency, Washington, D.C. RUDD, NOREEN, University of Calgary, Alberta Children's Hospital, Calgary,

Alberta, Canada RUSSELL, LIANE B., Oak Ridge National Laboratory, Oak Ridge, TN

SAKAI, CAROL, U.S. Environmental Protection Agency, Washington, D.C. SANDHU, S.S., U.S. Environmental Protection Agency, Research Triangle Park,

NC SAN SEBASTIAN, JUAN R., Pharmakon Research International, Inc., Waverly, PA SATYA-PRAKASH, K.L., The University of Texas, M.D. Anderson Hospital,

Houston, TX SCOTT, BARRY, Lone Oak Labs, Smithville, TX SEARLE, ANTONY G., Medical Research Council Radiobiology Unit, Oxon,

England SEGUIN-SPILLMAN, Lana, National Cancer Institute, Bethesda, MD SELEVAN, SHERRY, U.S. Environmental Protection Agency, Washington, D.C. SHARMA, RAJENDAR K., American Cyanamid Company, Princeton, NJ SHELBY, MICHAEL, National Toxicology Program, Research Triangle Park, NC SHEU, CHINGJU W., Food and Drug Administration, Washington, D.C. SICKEL, RUTH, Georgetown University Hospital, Washington, D.C. SIMI, SILVANA, Istituto di Mutagenesi e Differenziamento, Pisa, Italy SLINKER, BARBARA S., Centers for Disease Control, Atlanta, GA SMITH, DAVID A., University of California, San Diego, La Jolla, CA SONAWANE, BOB, U.S. Environmental Protection Agency, Washington, D.C. SORG, RUTH, Pharmakon Research International, Inc., Waverly, PA SPINNER, NANCY, Children's Hospital of Philadelphia, Philadelphia, PA STALCUP, TERESA A., Alfred I. DuPont Institute, Wilmington, DE STERN, HERBERT, University of California, San Diego, La Jolla, CA STETTEN, GAIL, Johns Hopkins University, Baltimore, MD STYLES, SALMA, Victoria General Hospital, Victoria, British Columbia,

Canada SYKES, ROBERT C., Baylor College of Medicine, Houston, TX

TANAKA, N., National Institute of Environmental Health Sciences, Research Triangle Park, NC

TANZARELLA, CATERINA, UniversitA di Roma, Roma, Italy TEPLITZ, RAYMOND L., City of Hope National Medical Center, Duarte, CA TESHlMA, IKUKO, Hospital for Sick Children, Toronto, Ontario, Canada THANGAVELU, MAYA, Memorial University, St. John's, Newfoundland, Canada THOMAS, MARYBETH, Bioassay Systems Corporation, Woburn, MA THOMPSON, E.D., Proctor and Gamble, Cincinnati, OH TICE, RAYMOND R., Brookhaven National Laboratory, Upton, NY TOUSSON, ALBERT, Baylor College of Medicine, Houston, TX TRASLER, TESSA, Montreal Children's Hospital, Montreal, Quebec, Canada TRUSLER, SUZANNE, Centers for Disease Control, Atlanta, GA

553

TSONGAS, THEODORA, Occupational Safety and Health Administration, Washington, D.C.

TUCKER, PRISCILLA K., Texas A&M University, College Station, TX TYRKUS, MICHAEL, Wayne State University, Detroit, MI

UCHIDA, IRENE A., McMaster University, Hamilton, Ontario, Canada ULLMAN, DEMETRA V., E.I. DuPont de Nemours & Co., Inc., Newark, DE

VALCOVIC, LARRY, U.S. Environmental Protection Agency, Washington, D.C. VALENCIA, RUBY, University of Wisconsin, Madison. WI VARTANIAN, MARGARET V., Los Angeles. CA VEKEMANS, M.J.J., Montreal Children's Hospital, Montreal, Quebec, Canada VOYTEK, PETER E., U.S. Environmental Protection Agency, Washington, D.C.

WAGGONER, DIANE D., Oregon Health Sciences University, Portland, OR WANG-WUU, SHENG, Institute of Zoology, Academia Sinica, Taipei, Peoples'

Republic of China WARBURTON, DOROTHY, Columbia University, New York, NY WATERS, MICHAEL D., U.S. Environmental Protection Agency, Research Triangle

Park, NC WENGER, SHARON L., Children's Hospital of Pittsburgh, Pittsburgh, PA WESTBROOK-COLLINS, BARBARA, Environmental Health Research and Testing,

Inc., Research Triangle Park, NC WHEELER, DONALD A., Edinboro University of Pennsylvania, Edinboro, PA WHITTAKER, STEPHAN G., University of California, Berkeley, CA WILEY, JOHN E., East Carolina University, Greenville, NC WILMER, JIM, Chemical Industry Institute of Toxicology, Research Triangle

Park, NC WILSON, CLAIRE M., Council for Research Planning in Biological Sciences,

Inc., Washington, D.C. WILTSE, JEANETTE A., U.S. Environmental Protection Agency, Washington, D.C. wORGLER, F.E., University of Zurich, Schwerzenbach, Switzerland WURSTER-HILL, DORIS H., Dartmouth Medical School, Hanover, NH WYDNER, K., Rutgers Medical School, New Brunswick, NJ WYROBEK, ANDREW J., Lawrence Livermore National Laboratory, Livermore, CA

XIA, JIAHUI, Hunan Medical College, Hunan, People's Republic of China

YAMAMOTO, JUDITH, Alberta Children's Hospital, Calgary, Alberta. Canada

ZIMMER, DAVID M., The Upjohn Company, Kalamazoo, MI ZIMMERING, STANLEY, Brown University, Providence, RI ZIMMERMANN, FRITZ, Genetik, Technische Hochschule, Darmastadt, Federal

Republic of Germany ZUNICH, JANICE, West Virginia University Medical Center, Morgantown, WV

554

INDEX

Abnormal disomic ova, 127 Abnormalities of speech, 21 Abnormal mitoses, 165, 283 Abortions, 41

trisomic abortions, 159 trisomic abortuses, 179

Achiasmic Dipteran males, 397 Acrocentric chromosomes, 95, 112

heteromorphisms of, 141 in humans, 139

Acrocentric trisomies, 139 Actinomycin D, 466, 498 Acyclicity, 426 Adenyl cyclase, 499 Affinity-purified antibodies, 339 Aging, 291, 378, 439

age effect, 542 component of, 439 in mouse, 411 physiological, 411

Alcoholism, 36 Alkylating agents, 492 Alpha-I-antitrypsin Alzheimer disease, 3-Amino-S-triazole, Amitrole, 472

genotype, 180 472

145

Amniocentesis, 9, 35, 63, 133, 182 Amphotericin B, 499, 500 Anesthetics, 494 Aneuploidy, 439

age effect, 542 autosomal, 516 cellular origin of, 540 chemically induced, 445 diazepam-induced, 498 environmental causes of, 150 human aspects, 540 meiotic, 541 prone individuals, 133 spontaneous, 513

Aneuploidy Data Review Committee, 445

Aniridia, II, 168 Anorexia nervosa, 180 Antibiotics, 153 Antibodies,

affinity-purified, 339 monoclonal, 339

Anticancer drugs, 494 Antikinetochores,

antibody, 339 antiserum, 247 serum, 284

Antineoplastic agents, 497 Antineoplastic alkaloid, 462 Antipyretics, 153 Antithyroid antibodies, 144 Antitubulin, 250 Antivimentin antibody, 340 Anucleate sperm, 17 Aprotic polar solvents, 438 Arrested mitotic spindles, 527 Asbestos, 528 Aspergillus, 448, 456, 459, 481,

497 !. nidulans, 421, 515

Asteral fibers, 298 Asters, 209, 280 Asynapsis, 77 Asynaptic axes, 379 ATP,

-dependent processes, 545 -independent processes, 545

Atrazine, 494 Atretic follicles, 420 AT-rich stretches of DNA, 439 Autoantibodies, kinetochore-

specific, 250 Autoimmunity, 12

in mouse, 340 Autosomes,

aneuploidy, 516 recombination, 438 trisomies, 8, 103, 389

5-Azacytidine, 525 Azathioprine, 448

Balance theory for tumorigenicity, 529

Banding techniques, 25, 165 C-banding, 76, 105, 380 G-banding, 76 Q-band ing, 76, 105 R-banding, 76

Bar eye, 354 Behavioral abnormalities, 20, 21

555

355 Belshazar (BEL), Benomyl, 4, 438, 448, 449, 459,

500 492, 496, Benzene, 1 Benzimidazol-derivative, Benzo(a)pyrene, 473 Bipolar spindle, 190 Bleomycin, 166, 474 Bombyx, oocytes, 345 Breast cancer, 166 Burkitt lymphoma, 171

421

Caenorhabditis elegans, 313 Caffeine, 475, 543 Calcium regulatory proteins, 495 Calmodulin, 303, 435, 495, 499 Carbamates, benomyl, 448 Cell fusion, 8 Cell transformation, 524, 527, 528 (CEN11)L sequences, 233 (cen11)1 spo13-1, 237 (CEN11)L transcript, 234 (CEN11)L transcriptional unit, 239 Centrioles, 281 Centromeres, 183, 231, 245, 279,

495, 497, 527 DNA, 297, 495

sequences, 492 dysfunction, 293 heterochromatin, 238 region, 93

Ceresan, 391 c(3)G, 436 Chemotherapy, 93 Chiasma, 398

frequen~ies, 122 interference, 397, 403 pattern, 87 regulation, h397

Chinchilla (c~) pink-eyed (E) offspring, 367

Chloral hydrate, 448, 465, 492, 500

Chloramphenicol, 423 Chlorpromazine, 499 Cholesterol, 423 Chondrodysplasia-punctata, 11 Chromatin, 434

despiralization, 93 -like fibrils, 247 of S-phase cells, 234 strand, 93

Chromosomes, 21, 145 aberrations, 501 abnormalities, 7, 91

de novo, 103, 106 meiotic, 91 postzygotic, 8 prezygotic, 8 zygotic, 8

anomalies, 175

556

Chromosomes, continued, banding techniques, 165, 541 breakage, 445 congression, 214 deletions, 96 displacement, 291 distribution, 183 exchanges, 96 fragments, 96 gaps, 96 giemsa-banded, 291 heteromorphisms, 103, 105 malsegregation, 377, 433 mis-segregation, 494 polymorphisms, 140 recombination, 397 segments, 403 segregation, 434 single-X, 103 syndromes, 19

Chronic myeloid leukemia, 165, 171 Cigarette smoking, 155, 411, 543 Ciliogenesis, Colcemid-induced, 256 Cleavage furrow, 276 Cloned mobile elements, 353 Coffee drinking, 153 Colcemid, 245, 247, 282, 284, 301,

448, 462, 492, 527 Colchicine, 179, 251, 280, 291,

301, 417, 421, 438, 448, 461, 492, 500, 513

Colchicum, 280 Cold treatment, 209 Color mutant, in Drosophila,

zeste (z), 356 Consanguinity, -143 Contraceptive spermicides, 155 Crane flies, 205 CREST antiserum, 250 Criminals,

psychopaths, 22, 29 with behavioral problems, 22

Crossing-over, 337 intrachromosomal, 353, 355, 357 unequal, 354

c-Telophase, 280 Cyclophosphamide, 348, 391, 448,

449, 476, 492, SIS, 546 Cytogenetic abnormalities, 17, 165 Cytogenetic techniques, 111 Cytosine arabinoside, 499, 500 Cytoskeletal intermediate filaments,

340

Dehistonization, with heparin, 250 Deletion-duplication tumors, 170 Deoxycholate, 309 Deoxynucleotide triphosphates, Depression, 38 Dermatoglyphic analysis, 141 Dermoid cysts, 17

308

Detergent, nonionic, 309 NP40 plus cholate, 250

Diakinesis/first metaphase, 75, 83, 379, 418

Diatoms, 203 Surirella, 215

Diazepam, 281, 282, 448, 494, 500, 518

as inducer of aneuploidy, 498 Dictyostelium, 198, 212

D. discoideum, 197 Diethylstilbestrol (DES), 243,

245, 252, 262, 282, 435, 448, 494, 497, 498, 500, 525, 544

blockage induced by, 253 related compounds, 525 transformation induced by, 526

DiGeorge anomalad, II, 12 Dimethyl sulfoxide (DMSO), 284,

438, 470, 519 Diminished mental capacity, 37 Diplotene, 339, 378, 389 Diplotene/diakinesis, 337 Diplo-X ova, 436 Disomic gametes, 384 Disomy, 168 Distamycin A/DAPI fluorescence, 76 Distributive pairing, 325, 327 Distributive Pairing Model, 317 Distributive pool, 380 Dithioerythreitol, 496 DJungarian hamster, 417, 418

Phodopus sungorus, 418 DNA, 434, 435

AT-rich stretches of, 439 polymorphisms, on chromosome 21,

145 repair, 435 replication, 319 synthesis, 234

Dominant-lethal experiments, 380 Dominant mutant, 354 Double mutants,

(cenll) 1 spo13-1, 237 Down syndrome, 7, 19, 96, 118,

166, 540 Drosophila, 3, 436, 448, 456, 482,

499, 516 Q. melanogaster, 353

Ear impairment, 37 Economic burdens. 35. 61 Economic costs, 61 Effective doses, 456

highest ineffective dose tested (HIDT) , 456

lowest effective dose tested (LEDT), 456

Endocrine control, 418 Endonuclease polymorphisms, 531 Endoreduplication, 298

partial, 299 Environmental causes of aneuploidy,

150 Environmental exposures, 153 Environmental risk factors, 127,

133, 543 Escherichia coli, 357 Estradiol, 426, 525 17S-Estradiol, 525, 527, 529 Estrogen excretion, Estrogens, 525, 544 Estrus, 378

518

cycle patterns, 411 Ethanol, 471 Ethidium bromide, 498, 500 Ethionine, 525 Ethnic origins, 543 Ethyl acetate, 438 Ethylene glycol, 519 Ethyl methanesulfonate (EMS),

3, 391, 438, 440, 448. 492 Eukaryotic spindle, 231 Euploid abortions, 152 Excision-defective mutant, 436 Extra chromosome 21, 75 Extra kinetochores, 190 Eye impairment, 37

Females, infertility in, 26 -like development, 166 meiosis, 76

Fenarimol, 500 Fetal deaths, 13, 377 Fetal ovaries, 76 Fluorescence redistribution after

photobleaching (FRAP), 211 kinetics of, 211

5-Fluorodeoxyuridine, 477 Formaldehyde, 302 Fragile-X(q27), 12, 21

syndrome, 21 Frameshift mutations, 525 Fungi, 452

Physarum polycephalum, 496 Fungicides, 494

Gametes, disomic, 384 nullisomic, 384

Gene mutations, 445, 501. 544 Genetic interference, 397 Genetic toxicology, 445 Genitourinary abnormalities, 168 Gerbil fibroma cells, 340 Germarial cyst, 318 Germarium, 318

557

Germinal-vesicle breakdown, 421 Germline nondisjunction tests,

378 Giesma-banded chromosomes, 291 Golden hamster eggs, 92 Gonadoblastoma, 166 Gonadotrophin-induced diploidy, 423 Gonadotrophins, 417, 418, 422

human chorionic, 418 Gout, 179 Grasshopper,

Chloealtis, 398, 399 ~. conspersa, 397

embryos, 283 neuroblast, 302 spermatocytes, 191

Griseofulvin, 448, 464, 492, 494, 496, 500

Gynecomastia, 27

Haemanthus, 199, 205, 221 Hantzschia, 205 Heart,

defects, 18 congenital, 18, 29

impairment, 37 Heat shocks, 435 Hemiovariectomized mice, 518 Heritable-translocation test, 383 Heterochromatin, 251

regions of, 93 Heteromorphisms, 26

of acrocentric chromosomes, 141 bivalents, 387 in chromosome banding, 541

Heterosynaptic phase, 345 HLA antigens, 144

shared parental, 144 Homologous synapsis, 314, 337,

344, 403, 405 Hordium, 462 Hormones, 160

fluctuation of, 518 3progesterone, 160

[H]-Thymidine, 307, 319, 341 pulse chase labeling experiments,

340 Human disorders,

autosomal, 417 gonosomal, 417

Human sperm, 91 Hydroxyurea, 344 Hymenopteran males, 397 Hypergonadotrophism,

follicular maturation, 429 hypogonadism, 26, 27 treatment, 424

Hyperhaploidy, 85, 379, 424 Hyperploidy, 412, 451 Hypohaploidy, 379 Hypoploidy, 291, 451

558

Hypospadius, 27 Hypothalamic-pituitary-gonadal axis,

427 Hypoxanthine phosphoribosyl trans­

ferase (HPRT), 524

Immunocytochemical staining, 247 Immunofluorescence, 247 Immunoperoxidase, 247 Indian muntjac cells, 284 Infertility, 540 Instability of spindle microtubules,

297 Intrachromosomal crossing-over,

353, 355, 357, 358 Intrafollicular preovulatory over­

ripeness, 413 Inversions,

heterozygote, 344 paracentric, 96 pericentric, 96 polymorphism, 326

Ionizing radiation, 392

JA2, 269

Karyotypic progression, 529 Kinases, 174 Kinetochores, 199, 243, 245, 273,

279, 377, 391, 495, 497 microtubules, 184 -specific autoantibodies, 250

Kinetochore-to-pole fibers, 298 Klinefelter syndrome, 27, 67, 166,

507, 540

Langer-Giedion syndrome, 11 Lax synapsis, 401, 406 Leptotene, 76, 338, 389 Leptotene-protein, 308, 309 Leptotene/zygotene, 348 Leukemia, 2 Lily, 343

Lilium, 305, 306 Limb abnormalities, 12 Lipid peroxidation, 303 Liveborns suddenly dying, 18 Long Y chromosome, 26 Loss,

anatomical, 37 mental, 37 psychological, 37

Love Canal study, 180 L-Protein, 308, 309 Lymphocytes,

cultures of, 143 in humans, 293

Lymphomas, 172

Macaques, 17 Maize, 353

Mass-screening programs, 508, 513 Maternal age, 117, 133, 392

dependence, 118 independence, 118

Maternal irradiation, 154 Mating hormone a-factor, 235 Medicago sativa~ 464, 480 Megalo testes, 11 mei-9, 436 Meiosis, 397

aneuploidy, 541 chromosome nondisjunction, 355 failure, 8 investigations, 75 maternal meiosis I, 107 mutants, 435 prophase, 339

Melanomas, 171, 172 Mendelian segregation, 233, 355 Meningioma, 171 Menopause, 411 Menstrual weeks, 13, 16 Mental illness, 35 Mental retardation, 20, 35, 168

institutions, 22 mental-penal institutions, 22

6-Mercaptopurine, 383 Mercuric chloride, 500 Messenger RNA, 234, 495 Metacentric chromosomes, 420, 424 Metaphase foci, 197 Metaphase plate, 417 Metaphase spindle, 197 Methyl 2-benzimidazolecarbamate

(MBC) , 4, 417, 448, 492, 496, 519

Methyl methanesulfonate (MMS), 389, 391, 448, 478, 492

Methyl-N-nitronitrosoguanidine (MNNG) , 492

Miconazole, 500 Microsporocytes, 306 Microtubules, 183, 207, 280

associated proteins (MAPs), 269 blockers of, 528 dynamics of, 210, 270 inhibitors of, 424 organization of, 526 polarity, 218

Microtubule organizing centers (MTOCs) , 245

Microtus oeconomus, 380 Miller-Dieker syndrome, 11 Mitochondria, 423, 424 Mitomycin C, 243, 244, 250, 346 Mitosis,

aneuploids, 448 aneuploidy, 143 arrest of, 280 inhibition of, 527 inhibitors, 251

Mitosis, continued, inhibitors, continued,

diethylstilbestrol, 252 mitomycin C, 251

motors, 190 nondisjunction, 179 poisons, 279 recombination, 168 spindle, 197, 527

Mock-albino, 366 Molecular composition, 245 Molecular techniques, 111

cloning, 353 Moles, hydatidiform, 17 Monobrachial homology, 365, 373,

378 Monoclonal antibodies, 269, 339 Monopolar spindle, 190 Monosomy, 8, 103, 107, 168, 378

embryos, 409 X, 123, 133, ISO, 542 zygotes, 518

Morphological transformation, 524, 525

Mosaicism, trisomy, 108, 182 mosaic 45,X, 8

Mouse, 95, Ill, 343, 411 CBA, 410, 425 hemiovariectomization, 518 NMRI/Han, 417, 418" 422, 425 oocytes, 498 tobacco mouse, 366

Mus poschiavinus, 384 Mutant genes, 237

spo13-1, 237 Mutants,

in Drosophila, c(3)G, 436 forked bristles (!), mei-9, 436

358

white eye color (w), 358 yellow body color-(y), 358

in yeast, rad50, 436 rad52 , 437 spoll, 436

+ + Na /K ATPase gene, 524 Neoplastic transformation,

525, 528 asbestos-induced, 528

Neuroblastomas, 171

433,

Neurospora, 448, 456, 461, 482 Nocodazole, 209, 302, 438, 496 Noncomplementation phenomena, 363,

364 Nondisjunction, 98, 122, 291, 297,

391, 417, 439, 529 chromosomes, 291 events, 75, 363

559

Nondisjunction, continued, induced, 377 meiotic, 8, 433 mitotic, 9, 12 paternal, 110

Nonhomologous synapsis, 344 Nuclear membrane, 276 Nuclease digestion, 245 Nucleases, 284 Nucleolus, 302 Nucleolus organizers, 122, 420 Nucleolus-organizing regions

(NORs) , 139, 543 Nude mice, 524 Nullisomic gametes, 384 Nullisomy, 95, 168 Numerical sex-chromosome anomaly

(NSA) , 388

Ochromonas, Oedogonium, Oncogenes,

203, 205 199, 206, 215

433, 523 ras, 523 c-Has ras, 169

p-Has ras, 169 v-Ha-ras plus v-myc, 532

putative,- 169 Oocytes, 92, 318

of Bombyx, 345 in humans, 440 in mouse, 498 preleptotene, 391 preovulatory, 159, 391

Oral contraceptives, ISS, 543 Orcein, 180 Organic mercury compounds, 497 Organic solvents, 494 Osteosarcomas, 167 Ouabain-resistant cells, 524 Ovarian failure, 26 Ovarian steroids, 426 Ovulated oocytes, 418, 425

Pachytene, analysis, DNA, 305

318, 339, 348 77

Parthenogenesis, 8 development, 17 insects, 397 yeast, 397

Patau syndrome, 67, 540 Paternal age, 117, 121, 124 Pediatric cardiologists, 18 Peptidyl transferase, 423 Pericentromeric regions, 107 Perichromatin, 302 Perifertilization period, 153 Perinatal deaths, 18 Peripheral lymphocytes, 12 Pesticides, 4, 494

benomyl, 448

560

p-Fluorophenylalanine, 448, 452, 469, 497

Phenotypes, in Drosophila, forked bristles, 358 not yellow, 358 red-eyed, 358 white-eyed, 358

Philadelphia chromosome, 171 in chronic myeloid leukemia, 165

Phosphorylation, 174 Physarum polycephalum, 496 Plants, 445

Medicago sativa, 464, 480 Plasmid molecules, 233 Polarized kinetochore position, 190 Polarized motors, 183 Pole-directed forces, 214 Polymorphisms, 541 Polyoma DNA, 532 Polypeptides, 243 Polytene chromosome cytology, 354,

356 Polytene salivary gland chromosomes,

353 p-onc Genes, 174 Postmeiotic germ cells, 378 Postmidterm (fetal) death, 377, 381 Postzygotic chromosomal aberrations,

12 Prader-Willi syndrome, II, 12 Precocious centromere division, 378 Preimplantation mouse embryos, 381 Prekinetochores, 250 Preleptotene, 391 Premeiotic S-phase, 306, 341, 348 Prenatal cytogenetic diagnosis, 544 Preneoplasia, 531 Preneoplastic populations, 524 Preovulatory oocytes, 159 Prezygotic origin, 8 Primary amenorrhea, 26 Progesterone, 160, 426 Prometaphase-like spindle, 302 Prometaphase shortening of the

spindle, 275 Pronuclear chromosomes at first

cleavage, 377, 380 Protein kinases, 495 Proto-oncogenes, 523 Pseudohermaphrodites, 12, 27 Pseudothalidomide syndrome, 12 Psn-protein, 315 PsnRNA, 315 Puberty,

absent, 27 delayed, 27

Puccinia, 205 Pyrimidine dimers, 438, 439

Q-Band polymorphism, 75 Quinacrine mustard fluorescence, 76

rad50, 436 rad52, 437 Radioimmunoassay, 426 Radiotherapy, 93, 97, 543 Rat kangaroo cells, 251 Rearrangements, 445

de novo, 9 parental, 142

Reciprocal recombination, 405 Recombination, 320 Red blood cells, Xg antigens of,

541 Reduced repair capabilities, 439 Reductional segregation of homolo­

gous centromeres, 397 Reduction in motor control, 37 Reorientation, 185, 188

preferential, 186 Repositories, 510 Rescue by fusion, 516 Reticuloendothelial neoplasms,

166, 171 Retinoblastomas, 11, 166, 531

sporadic cases of, 167 Risk factors,

for trisomy, 133 genetic, 139

Robertsonian heterozygotes, 373 Robertsonian tester stocks, 390 Roberts syndrome, 12

Saccharomyces, 198, 448, 456, 459, 480

S. cerevisiae, 231, 313, 433 ScIara, 299 Scleroderma CREST, 250

antiserum, 243, 251 autoantibodies, 262

Scleroderma patient, 284, 339 Sea urchin eggs, 165, 209 Seminoma of the testis, 97 Sera of CREST (scleroderma)

patients, 339 Sex chromosomes, 103, 377

abnormalities of, 20, 25 nondisjunction, 388

Sexual development, 540 Sexual differentiation, 22 Sexual dimorphism, 326 Sickle cell disease, 67 Simazine, 479 Sister chromatids, 191, 435

exchange, 346 rates, 12

Slime mold, 197 Dictyostel1um, 197, 198, 212

Social costs, 40, 45, 52, 65 Sodium celanate, 303 Sordaria, 313, 519

S. brevicollis, 514, 515 Spermatids, 378

Spermatogenesis, 75 Spermatogonia, 82 Spermatozoa, 378 Sperm chromosomal abnormalities,

94 Sperm chromosome identification, 93 S-Phase cells,

chromatin of, 234 premeiotic, 306

Spindle, 513 action, 216 apparatus, 279, 280, 391 defects, 412 fibers, 377 formation, 209 inhibitors, 421, 429

methyl benzimidazolecarbamate, 421

as labile collection of fibers, 189

microtubule instability, 297 poles, 197 prometaphase shortening of, 275 structure, 197, 203

spolO, 239 spoIl, 436 spo13-1, 237 Spontaneous abortions, 94, 103,

109, 133, 138, 409 trisomic, 136

Spontaneous aneuploidy, 513 Spore tetrads, 235 Sporulation, 234 Steroids, 417 Stillbirths, 13, 17, 18

macerated, 18 Structural polarity, 201 Structural rearrangement, 7 Structure activity relationships, Submetacentric chromosomes, 420,

424 ~(Hw), 355 Supernumerary sex bodies, 379 Suppressor mutation, 355 Surface-spreading, 76, 338 Surirella, 215 Synapsis, 320, 329

adjustment, 346 anomalies, 412 associated proteins, 305 extension, 401 homologous, 337, 344, 403, 405 mechanisms of, 397 morphology, 337 nonhomologous, 344

Synaptonemal complex, 337, 397, 398, 435, 436

Syphilis, 65 Syrian hamster, 525

embryo cell transformation, 523

561

T(5;8)a, 364 Taxol, 282, 494, 497, 500 Tea, 153 Telophase, 280 Teratomas, 17 Tertiary trisomy, 377 Testis,

biopsies, 23, 76, 82 radiation, 97 specific B-tubulin, 437

Testosterone, 426 Tetrachloroethylene, 465 Tetrahymena, 205 Tetraploidy, 7, 8, 133, 150, 280 TG-resistant cells, 524 Theca cells, 419 6-Thioguanine, 524 TlKAUT-normal T6 fibroblast

hybrids, 531 Topoisomerase activity, 310 Toxicity,

developmental, 2 reproductive, 2

Toxicology, 437 Transformation by oncogenic

viruses, 166 Translocation Down syndrome, Translocation heterozygotes, Translocation intercrosses, Translocations, 96, 451

reciprocal, 3, 364

119 96

364

Robertsonian, 96, 124, 364, 370, 378, 384, 517

T(5;8)a, 364 Transmembrane signals, 499 Transmissible gametic aneuploidy,

363 Transmissible gene mutations, 544 Triaziquone, 467, 483 Trichloroacetaldehyde, 465 Trichloroethylene, 465 Triethylenemelamine (TEM), 389 Trifluralin, 492, 494, 500 Triploidy, 7, 8, 150 Trisomies, 8, 103, 109, 133, 134,

139, 168, 377, 542 trisomy I, 95 trisomy 8, 172, 173 trisomy 11, 528 trisomy 13, 18, 19 trisomy 16, 108 trisomy 18, 18, 19 trisomy 21, 75, 133, 149

phenotype of, 117 autosomal, 389 conceptuses, 427 offspring, 87 tertiary, 377

Trypsin, 284 Tubulin, 207, 280, 434

562

Tubulin, continued, binding compounds, 514 fluorescent, 211 FRAP, 211 messenger RNA, 495 polymerization, 413, 496

Tumors of the breast, cervix, colon, and ovary, 171

Turner syndrome, 12, 27, 103, 111, 180, 411, 507, 540

Ultrabar, 354 Unemployment, cyclical, 43 Unequal crossing-over, 354 Unilateral orchidectomy, 97 Unilateral ovariectomy (uni-ovx),

410, 411

Valium, 281, 282, 494, 500, 518 v-Ha-!!! plus v-myc DNAs, 532 Vimentin, 340 Vinblastine, 281, 282, 448, 463,

492, 494, 497, 502 Vinblastine sulfate, 463 Vinca alkaloids, 281, 497 Vincristine, 281, 497 Vincristine sulfate, 527 Vitamin E, 303 v-onc Genes, 174

White-eye (w) locus, 354, 358 Wild-type X-chromosome, 358 Wilms tumor, II, 166, 168

X-chromosomal monosomy, 542 X chromosome ratio, 96 Xg antigens of red blood cells,

541 Xg blood group, 103, 104 X-ray-induced recombination, 437 X-rays, 166

experiments, 386 XX moles, 8 XX (teratoma), 8

Y chromosome ratio, 96 Yeast, 436

excision-defective mutant, 436 Saccharomyces cerevisiae, 231,

313, 433

Zona pellucida-free hamster eggs, 92

Zygotene, 76, 318, 339 DNA, 305

Zygotes, 95, 363 monosomic, 518