723

INDEX

Volume 21 5, October-December 1980

A-23l87, role in purine releasefrom vascular adrenergicnerves (rabbits), 685

Abe, H., see Yuasa, S., 254

Abu-Hamdan, D., see Migdal, S.D., 304

Acebutolol, effect on action po-tential in papillary muscles(guinea pigs), 507

Acetazolamideaction on fluid and 5,5-di-

methyl-2,4-oxazolidinedione

absorption by proximal tu-

bule (rats), 557

effect on choroid plexus epithe-hal cell sodium and potas-

sium (rats), 673

Acetyicholine

brain, effect on baroreceptor re-flexes (rats), 309

inhibition of cyclic AMP in em-bryonic ventricle (chick), 348

in perfused heart, uptake ofcholine after release of(chickens), 710

receptors, changes in vas def-erens after denervation

(guinea pigs), 716

Acetylcholinesterase, inhibition

by BW 284c51, pre- and post-synaptic neuromuscular ef-fects (rats), 53

l-a-Acetyldinormethadol, electro-encephalographic and behav-

ioral effects (rats), 382

1-o-Acetylmethadol (LAAM)

comparative cardiac actionswith morphine, meperidine,pentazocine, fentanyl andmethadone (cats), 259

electroencephalographic andbehavioral effects (rats), 382

radioimmunoassay of (dogs,

rabbits), 2051-a-Acetylnormethadol, electro-

encephalographic and behav-ioral effects (rats), 382

Acetylstrophanthidin-induced os-

cillatory afterpotentials inventricular tissues, effects of

transmembrane potential on(dogs), 332

Acidosis, effect on choroid plexus

epithelial cell sodium and po-

tassium (rats), 673Ackerman, N., Tomolonis, A.,

Miram, L, Kheifets, J., Mar-tinez, S. and Carter, A: Threeday pleural inflammation: Anew model to detect drug ef-

fects on macrophage accu-

mulation, 588Adenylate cyclase, role of hydro-

cortisone in potentiation of

(man), 469Adolphson, R. L., see Duncan, P.

G., 434Adrenergic activity, alpha, effects

on vasoconstriction by ad-renergic nerve stimulation(rabbits), 377

Adrenergic blockage, alpha, ef-

fect on norepinephrine gan-

glion depression (dogs), 522

Adrenergic blockers, beta, effectson action potential in papil-lary muscles (guinea pigs),

507

Adrenergic nerve ( see Nerve, ad-renergic)

Adrenergic receptors ( see also

Adrenoreceptors)alpha-2, involvement in regu-

lation of insulin release andblood glucose levels (rats),226

beta, cardio-selective stimula-tion with prenalterol (dogs),

266

beta- 1 and beta-2, interactionswith antagonist and agonistin jugular vein (rats), 325

Adrenoreceptors ( see also Adre-

nergic receptors)function of tracheal and paren-

chymal strips, effects of vac-cination with Haemophilus

influenzae (guinea pigs), 691

Adriamycin, toxicity, regulatory

role of glutathione andsulthydryl groups in (mice),450

Afterpotentials, oscillatory, in-duced by acetylstrophanthi-din in ventricular tissues, ef-fects on transmembrane po-

tential on (dogs), 332

Age, effects on oxazepam kinetics(man), 86

Airway musclecontraction/relaxation, role of

cyclic nucleotides (guineapigs), 434

response and sensitivity to ag-onists during ontogenesis

(guinea pigs), 426Alcohol dehydrogenase, liver, ef-

fects of castration and mor-phine (rats), 317

Alderdice, M. T. and Trommer,B. A.: Differential effects ofthe anticonvulsants pheno-barbital, ethosuximide and

carbamazepine on neuromus-cular transmission, 92

Allen, R. C., see Knodell, R. G.,619

Alpha-i, adrenergic receptors in

heart, characterization by us-

ing [3H]WB41O1 (rats), 176Aminosugar, effect on cardiac gly-

coside activity (dogs), 198

2-Aminotetralins, presynaptic ef-fects on striatal dopaminergic

neurons (rats), 486Amitriptyline, regulation of sero-

tonin2 receptors labeled with[‘H]spiroperidol by (rats),582

Amphetamine-haloperidol inter-actions on brain tyrosine hy-droxylase activity and dopa-mine metabolism (rats), 135

d-Amphetamine, effects on be-havior (rats), 9

Amsterdam, E. A., see Rendig, S.

V., 259

Analgesiamorphine, effects of na1 xone

(rats), 626

morphine, spinal and � .ipra-spinal sites of action t ats),

633

Anesthesia, spinal, effect on �ior-

epinephrine ganglion depres-

sion (dogs), 522

Anesthetics, general, inhibiton of

cardiovascular reflexes (cats),418

Anthopleurin-A-induced prolon-gation of action potential of

cardiac ventricular muscle(guinea pigs), 479

Antihypertensive effect, of pro-pranolol in central nervoussystem (rats), 221

Antinociceptive action

of morphine, sites in brain(rats), 626

of morphine, spinal and supra-spinal sites (rats), 633

Aorta, smooth muscle, norepi-nephrine actions on �Ca up-take and release in (rabbits),363

Arachidonic acid, metabolism inpulmonary artery (rabbit),240

Arginine vasopressm, and ana-

logs, effect on synthesis of

prostaglandin E� by renalmedullary cells (rat), 15

Artery

coronary, thrombosis, effects ofibuprofen (dog), 271

occlusion, cause of vasodilation,influence of histamine (dogs),533

Aryl hydrocarbon hydroxylase,activity in prostate glands, in-

duction by 2,3,7,8-tetrachlo-

rodibenzo-p-dioxin (rats), 601

Atria, isolated, responses to adre-

nergic nerve stimulation dur-ing chronic tricyclic antide-

pressants (rats), 143

Autonomic responses, of urinarybladder, effect of estrogen(rabbits), 614

Awad, S. A., see Twiddy, D. A. S.,500

Axelson, J. E., see Venkatara-manan, R., 231, 235

Azzaro, A. J., see Demarest, K. T.,461

Baba, N., see Unverferth, D. V,527

Baclofen, inhibition of cardiovas-cular reflexes (cats), 418

Ban, T., see Sada, H., 507

Baroreceptor control, of sympa-thetic tone in heart, devel-

opment (rats), 596Barr, J. G., Diz, D., Kauker, M. L.

and Nasjletti, A: Effect of theconverting enzyme inhibitorSQ-20881 on urinary excre-

tion of prostaglandin E2 inthe rat: Influence of pretreat-ment with deoxycorticoster-one, 172

Bartolome, J., Mills, E., Lou, C.and Slotkin, T. A.: Matura-

tion of sympathetic neuro-

transmission in the rat heart.V. Development of barore-ceptor control of sympathetictone, 596

Beck, T. R., Hassid, A. and Dunn,M. J.: The effect or arginine

vasopressin and its analogson the synthesis of prosta-glandin E2 by rat renal med-ullary interstitial cells in cul-

ture, 15

Behaviordrug self-administration, dou-

ble-blind choice comparisonof pentobarbital, diazepamand placebo (man), 649

effects of drugs (rats), 9

effects of narcotics (rats), 382

role of bupropion in blockade ofdopamine uptake (rats), 127

stereoselective stimulus effects

of morphine and cyclazocine

(monkey), 369Benet, L. Z., see Frey, F. J., 287Bentley, J. B., see Miller, M. S.,

292

Bentolila, J. J., see Wiggins, J. R.,569

Benzidine, metabolism, by pros-taglandin-mediated process

724 Index Vol. 215

in kidney (rabbits), 401

Benzolamide, effect on choroidplexus epithelial cell sodiumand potassium (rats), 673

Bernard, J. D., see Cicero, T. J.,

317

Bethanecol, after spinal cordtransection, response of blad-

der to (cats), 500Biegon, R. L., Epstein, P. M. and

Pappano, A. J.: Muscarinicantagonism of the effects ofa phosphodiesterase inhibi-tor (methylisobutyixanthine)in embryonic chick ventricle,

348

Bigelow, G. E., see Griffiths, R.R., 649

Bileexcretion and metabolism of

phenytoin in isolated per-fused liver, effect of estradiol-

17$ (rats), 71

excretion of morphine, in-hibited by dehydrocholate

(rat), 116

Bile duct, ligation, effects on pen-tobarbital and mependinepharmacokinetics (rats), 619

Bladderresponse to bethanecol after

spinal cord transection (cats),

500urinary, autonomic responses,

effect of estrogen (rabbits),614

urinary, interaction of calciumand microtubules in action ofcyclic AMP (toads), 254

Blood glucose, levels, involve-ment of alpha-2 adrenergicreceptors in regulation of(rats), 226

Boerth, R. D., see Olson, R. D.,450

Bois, R. T., Hummel, R. G., Dett-barn, W. and Laskowski, M.B.: Presynaptic and postsyn-aptic neuromuscular effectsof a specific inhibitor of ace-

tylcholinesterase, 53

Bondy, B., see Fichtl, B., 248

Boyd, M. R., see Buckpitt, A. R.,

97

Bradycardia, reflex-induced, ef-fect of brain acetylcholine

(rats), 309Brain

acetylcholine, effect on barore-ceptor reflexes (rats), 309

dopamine-containing neurons,

type A monoamine oxidase

(rats), 461electrophysiological evidence

for presynaptic actions of

phencyclidine on noradrener-gic transmission in (rats),

606

neurotensin, increase elicited

by neuroleptics (rats), 413serotonin2 receptors labeled

with [3H]spiropendol by reg-ulation of amitriptyline(rats), 582

Brater, D. C., see Chennavasin,

P., 77

Braunwald, E., see Manders, W.T., 266

Brezenoff, H. E., see Caputi, A. P.,309

Brink, C., see Duncan, P. G., 434Brink, C., Duncan, P. G., Midzen-

ski, M. and Douglas, J. S.:Response and sensitivity offemale guinea-pig respiratorytissues to agonists duringontogenesis, 426

Brooks, D. A., see Knodell, R. G.,619

Brown, W. W., see Rapp, N. S.,

401

Buckpitt, A. R. and Boyd, M. R.:

The in vitro formation of glu-

tathione conjugates with themicrosomally activated pul-

monary bronchiolar alkylat-ing agent and cytotoxin, 4-iopmeanol, 97

Bupropion, behavioral and bio-chemical effects, role ofblockade of dopamine uptakein (rats), 127

Burks, T. F., see Weisbrodt, N.

W., 515

Bush, L. R., see Romson, J. L.,271

BW 284c51, inhibition of acetyl-cholinesterase, pre- and post-synaptic neuromuscular ef-fects (rats), 53

Caldwell, R. W., see Cook, L. S.,198

Calciumchannel blockade, phenytoin

inhibition of cyclic GMP ac-

cumulation in neuroblastomacells by (man), 575

fluxes in pancreatic islets, roleof K� conductance (rat), 213

interaction with microtubulesin action of cyclic AMP onurinary bladder (toads), 254

Calcium-45, uptake and release inaortic smooth muscle, nor-epinephrine actions on (rab-bits), 363

[‘251}Calmodulin binding, in stria-turn, effects of lanthanum

and trifluoperazine (rat), 28Captopril

effect on NaCl appetite (rats),

407

-induced renal vasodilatationafter nonhypotensive hernor-rhage (dogs), 104

Caputi, A. P., Rossi, F., Carney,

K. and Brezenoff, H. E.: Mod-ulatory effect of brain acetyl-choline on reflex-inducedbradycardia and tachycardia

in conscious rats, 309Carbamazepine, effects on neuro-

muscular transmission

(frogs), 92

Cardiac glycosideactivity, effect of aminosugar

(dogs), 198

positive inotropic effect, sodiumdependence of (cats), 569

Cardiovascular reflexes, inhibi-tion by baclofen and general

anesthetics (cats), 418

Carney, K., see Caputi, A. P., 309

Carpinelli, A., see Herchuelz, A.,

213

Carter, A., see Ackerman, N., 588Castration, effects on liver alcohol

dehydrogenase and metabo-

ham of ethanol (rats), 317

Catabolism, protein, in liver, ef-fect of mirex (rats), 82

Catecholaminergic, lesions, neo-natal central, effect on mat-uration of sympathetic neu-rotransmission in heart (rat),342

Cations, organic, transport in kid-

ney plasma membrane vesi-des (dogs), 191

Cellepithelial, choroid plexus, so-

dium and potassium, effect ofcarbonic anhydrase inhibi-

tors and acidosis (rats), 673neuroblastoma, phenytoin in-

hibition of cyclic GMP accu-mulation by calcium channel

blockade in (man), 575

Cephaloglycin, nephrotoxicity(rabbits), 186

Cephalosporins (see specific drug)

Cerebrospinal fluid, transport ofcholine, N’-methylnicotin-amide and hexamethoniumfrom (rabbits), 563

Chan, Y. L.: Different mecha-nisms of action of acetazol-amide and parthyroid hor-mone on proximal tubularabsorption of fluid and 5,5-di-methyl-2,4-oxazolidinedione,

557

Chan, Y. L.: The role of norepi-nephrine in the regulation offluid absorption in the rat

proximal tubule, 65Chau, T. T. and Harris, L. S.:

Comparative studies of thepharmacological effects of

the d- and I-isomers of co-deine, 668

Cheng, L., see Lipsky, J. J., 390Chennavasin, P., Seiwell, H. and

Brater, D. C.: Pharmacoki-netic-dynamic analysis of the

indomethacin-furosemide in-

teraction in man, 77Choline

transport from cerebrospinal

fluid (rabbits), 563uptake after release of acetyl-

choline in perfused heart(chickens), 710

Cholinesterase, serum, hydrolysisof heroin (diacetylmorphine)(man), 1

Choroid plexus, epithelial cell so-dium and potassium, effect ofcarbonic anhydrase inhibi-tors and acidosis (rats), 673

Cicero, T. J., Bernard, J. D. andNewman, K.: Effects of cas-tration and chronic morphineadministration on liver alco-hol dehydrogenase and themetabolism of ethanol in the

male Sprague-Dawley rat,

317

Cigarette smoke, effect on oxa.ze-

pam kinetics (man), 86Clearance

prednisolone, at steady state

(dogs), 287

renal, of digoxin (dogs), 681Cocaine, effects on cardiac re-

sponses to norepinephrine(dogs), 20

Coceani, F., see Lock, J. E., 156Codeine, d- and 1-, comparative

studies of pharmacological

effects (mice, cats), 668Cohen, M. L., Ruffolo, R R. Jr.

and Wiley, K. S.: Antagonist

dissociation constants andrelative agonist efficacies forcompounds interacting withbeta-i and beta-2 adrenergicreceptors in the rat jugular

vein, 325Cook, J. A., see Wise, W. C., 160Cook, S. L, Caldwell, R W. and

Nash, C. B.: Changes in car-

diac glycoside activity pro-

duced by aminosugar addi-tion, 198

Copeland, E. M., see Weisbrodt,N. W., 515

Cohen, R., see Kupersmith, J., 394Colchicine, action on urinary

bladder, role of calcium(toads), 254

Cook, M. A., see Okwuasba, F. K.,704

Cooper, B. R., Hester, T. J. andMaxwell, R. A.: Behavioraland biochemical effects of theantidepressant bupropion

(Weilburtin): Evidence forselective blockade of dopa-mine uptake in vivo, 127

Costa, E., see Govoni, S., 413

Crews, F. T. and Smith, C. B.:Potentiation of responses toadrenergic nerve stimulationin isolated rat atria duringchronic tricycic antidepres-sant administration, 143

Croskery, R., see Unverferth, D.V., 527

Cubeddu, L. X., see Hoffmann, I.S., 486

Cyclazocine, stereoselective stim-

ulus effects (monkey), 369Cyclic adenosine 3’ : 5’-monophos-

phate, in superior cervicalganglion (rats), 297

Cyclic AMPaction on urinary bladder, in-

teraction of calcium and mi-crotubules in (toads), 254

inhibition of accumulation byacetylcholine in embryonicventricle (chick), 348

response of lymphocytes, effectof hydrocortisone on (man),469

role in contraction/relaxationin airway muscle (guinea pig),434

Cyclic guanosine 3’:5’-monophos-phate, in superior cervicalganglion (rats), 297

Cyclic GMP

1980 Index 725

accumulation in neuroblastomacells, phenytoin inhibition bycalcium channel blockade(man), 575

role in contraction/relaxationin airway muscle (guinea pig),434

Cyclic nucleotides, role in con-traction/relaxation in airwaymuscle (guinea pig), 434

Daniel, A. and Honig, C. R.: Doeshistamine influence vasodi-lation caused by prolongedarterial occlusion or heavyexercise?, 533

Davis, B. B., see Rapp, N. S., 401Dedek, J., see Scatton, B., 494Dehydrocholate, inhibition of

morphine, biiary excretion

(rat), 116Demarest, K. T., Smith, D. J. and

Azzaro, A. J.: The presenceof the type A form of mono-amine oxidase within nigro-striated dopamine-containing

neurons, 461Denervation, changes in cholin-

ergic system in vas deferensafter (guinea pigs), 716

Deoxycorticosterone, pretreat-

ment, influence on effect of

SQ-20881 on urinary excre-tion ofprostaglandin B2 (rat),172

i-Desamino-8-D-arginine vase-

pressin, effect on synthesis ofprostaglandin E, by renalmedullary cells (rat), 15

Deskin, R., Mills, E., Whitmore,W. L., Seidler, F. J. and Slot-kin, T. A.: Maturation ofsympathetic neurotransmis-sion in the rat heart. VI. Theeffect of neonatal central ca-techolaminergic lesions, 342

Dettbarn, W. D., see Bois, R. T.,53

Dextran, segmented retrogradeintrabiliary injection in liver,transit patterns of (rats), 110

Diacetylmorphine (see Heroin)Diazepam, double-blind choice

comparison with pentobarbi-tal and placebo (man), 649

Dick, M. R., see Unverferth, D.V., 527

Digitalis, toxicity, role of mem-brane potential (dogs), 332

Digitoxin, positive inotropic ef-

fect, sodium dependence of(cats), 569

Digoxin

positive isotropic effect, sodiumdependence of (cats), 569

renal clearance (dogs), 681

5,5-Dimethyl-2,4-oxazolidine-dione, comparative action ofacetazolamide and parathy-roid hormone on proximal tu-

bular absorption of (rats),557

Diphenylhydantoin (see Pheny-tom)

Disposition

morphine, in liver, action of

SKF 525-A on, studied bysegmented retrograde intra-biiary injection (rat), 122

of enflurance, in obesity (man),292

of (-)- and (+)-propranolol(man, dog), 643

of tetrahydrocannabinol (man),

35Divoll, M., see Greenblatt, D. J.,

86

Diz,D.,seeBarr,J.G., 172Dobutamine, effect on myocardial

mitochondria (man), 527Dopamine

function in striatum, actions ofopiate receptor agonists/an-tagonists (rats), 697

-induced dilation of femoralvascular bed (dogs), 662

metabolism, brain, amphet-amine-haloperidol interac-tions on (rats), 135

metabolism, effects of yohim-bine (rats), 494

release and metabolism, in neo-striatum, presynaptic effects

of2-aminotetralins (rats), 486

uptake, role of bupropion inblockade of (rats), 127

Douglas, J. S., see Brink, C., 426Douglas, J. S., see Duncan, P. G.,

434

Downie, J. W., see Twiddy, D. A.S., 500

Drug binding, to muscle tissue(rabbits), 248

Dun, N. J. and Karczmar, A. G.:A comparative study of thepharmacological propertiesof the positive potential re-corded from the superior cer-vical ganglia of several spe-cies, 455

Duncan, P. G., see Brink, C., 426Duncan, P. G., Brink, C., Adolph-

son, R. L. and Douglas, J. S.:Cyclic nucleotides and con-traction/relaxation in airway

muscle: H and H2 agonistsand antagonists, 434

Dunn, M. J., see Beck, T. R., 15

Eckerson, H. W., see Lockridge,0., 1

Electroencephalogram, effects ofnarcotics (rats), 382

Electrophysiological effects

of phencyclidine on noradre-nergic transmission in cere-bellum (rats), 606

on ischemic, infarcted and nor-

mal tissue ofheart (dogs), 394Eller,T.,seeWise,W.C., 160Endocrine function, and growth,

effects of methylphemdate(rats), 545

Enflurane, disposition in obesity(man), 292

Epstein, P. M., see Biegon, R. L.,348

Erythritol, segmented retrogradeintrabiiary injection in liver,transit patterns of (rats), 110

Estradiol-i7/3, effect on metabo-ham and biiary excretion of

phenytoin in isolated per-fused liver (rats), 71

Estrogen, effect on autonomic re-sponses of urinary bladder(rabbits), 614

Ethanol, metabolism, effects ofcastration and morphine

(rats), 317

Ethosuximide, effects on neuro-

muscular transmission(frogs), 92

Etorphine, binding sites in retina(rats, cows, toads, skates), 60

Excretionbiiary, dehydrocholate inhibi-

tion of morphine (rat), 116

biiary, of phenytoin in isolatedperfused liver, effect of estra-diol-17f.� on metabolism and(rats), 71

urinary, of prostglandin E2, in-fluence of deoxycortiosteronepretreatment on effect of SQ-20881 (rat), 172

Exercise, heavy, cause of vasodi-

lation, influence of histamine(dogs), 533

Fentanyl, comparative cardiaccontractile actions with mor-phine, mependine, pentazo-cine, methadone and 1-a-ace-tylmethadol (LAAM) cats,

259Ferrier, G. R.: Effects of trans-

membrane potential on oscil-

latory afterpotentials in-duced by acetylstrophanthi-din in canine ventricular tis-

sues, 332

Fichtl, B., Bondy, B. and Kurz,H.: Binding of drugs to mus-cle tissue: Dependence ondrug concentration and lipidcontent of tissue, 248

Fluid, absorption in kidney, roleof norepinephrine and phen-oxybenzamine on regulation(rats), 65

Fravert, D., see Tune, B. M., 186

Freedman, R., see Marwaha, J.,606

Freeman, R. W., see Olson, R D.,450

Fregly, M. J.: Effect of the angio-tensin converting enzyme in-

hibitor, captopril, on NaCl

appetite of rats, 407Frey, B. M., see Frey, F. J., 287

Frey, F. J., Frey, B. M., Greither,A. and Benet, L. Z.: Prednis-olone clearance at steady

state in dogs, 287

Fujimoto, J. M., see Imamura, R.,110

Fujimoto, J. M., see Imamura, T.,

116

Fujimoto, J. M., see Imamura, T.,122

Furosemide-indomethacin interaction,

pharmacokinetic-dynamicanalysis (man), 77

pharmacokinetics and dynam-

ins, effect of indomethacin(man), 77

Gandolfi, J., see Miller, M. S., 292Ganglion

norepinephrine depression, ef-

fects of blocking agents(dogs), 522

superior cervical, comparativestudy of pharmacological

properties of positive poten-tial from (rabbits, cats,guinea pigs, rats), 455

superior cervical, cyclic nucleo-tide content of (rats), 297

Gentamicin, uptake by renalmembranes (rabbits), 390

German, D. C., see McMullen, B.

A., 150

Gibson, T. P. and Quintanilla, A.P.: The renal clearance of di-goxin is dependent upon theserum digoxin concentration,681

Glutathione

conjugation with 4-ipomeanol(rats), 97

regulatory role in toxicity ofAdriamycin (mice), 450

Gnegy, M. E., see Lou, Y., 28Goldberg, L. I., see Listinsky, J.

J., 662Govoni, S., Hong, J. S., Yang, H.-

Y. T. and Costa, E.: Increaseof neurotensin content elic-ited by neuroleptics in nu-cleus accumbens, 413

Greenaway-Coates, A., see Lock,J.E., 156

Greeley, G. H., Jr. and Kizer, J.S.: The effects of chronicmethylphemdate treatmenton growth and endocrinefunction in the developingrat, 545

Griffiths, R. R., Bigelow, G. E.,Liebson, I. and Kaliszak, J.E.: Drug preference in hu-mans: Double-blind choicecomparison of pentobarbital,diazepam and placebo, 649

Groth, H. D., see Howells, 60Greenberg, S.: Studies on the ef-

fect of chronic oral adminis-tration of minoxidil and hy-dralazine on vascular func-tion in spontaneously hyper-tensive rats, 279

Greenblatt, D. J., Divoll, M., Har-matz, J. S. and Shader, R. I.:Oxazepam kinetics: Effects ofage and sex, 86

Greither, A., see Frey, F. J., 287

Growth, and endocrine function,effects of methylphenidate

(rats), 545Guentert, T. W. and #{216}ie,S.: Effect

of plasma protein binding onquinidine kinetics in the rab-bit, 165

Haack, D. W., see Romson, J. L.,271

Haemophilus influenzae vacci-nation, effects on adrenocep-tor function of tracheal andparenchymal strips (guineapigs), 691

Haloperidol-amphetamine inter-

726 Index Vol. 215

actions on brain tyrosine hy-

droxylase activity and dopa-mine metabolism (rats), 135

Halushka, P. V., see Wise, W. C.,160

Hamilton, F., see Lock, J. E., 156

Harbison, R. D., see Olson, R. D.,

450

Hardwick, W. C., see McMillan,

W. T., 9Harmatz, J. S., see Greenblatt, D.

J., 86

Harris, L. S., see Chau, T. T., 669Hashiinoto, K., see Hashimoto,

K., 479

Hashimoto, K., Ochi, R., Hashi-

moto, K., Inui, J. and Miura,

Y.: The ionic mechanism of

prolongation of action poten-

tial duration of cardiac yen-tricular muscle by anthopleu-rin-A and its relationship to

the inotropic effect, 479Hassid, A., see Beck, T. R., 15Hats, F., Takeyasu, K., Mori-

kawa, Y., Lai, R.-T., Ishida,H. and Yoshida, H.: Specificchanges in the cholinergicsystem in guinea-pig vas def-

erens after denervation, 716Heart

action potential, effects of betaadrenergic blockers (guineapigs), 507

alpha- 1 adrenergic receptors in,

characterization by using

[3H]WB41O1 (rats), 176beta adrenergic stimulation

with prenalterol (dogs), 266contractile actions, comparison

of six narcotic analgesics

(cats), 259electrophysiologic effects of

manganese and verapamil onischemic, infarcted and nor-

mal tissue of (dogs), 394glycoside activity, effect of ami-

nosugar (dogs), 198maturation of sympathetic neu-

rotransmission (rats), 342,

596mitochondria, effect of dobu-

tamine (man), 527

perfused, uptake of cholineafter release of acetylcholinein (chickens), 710

responses to norepinephrine,

effects of cocaine and mets-nephrine (dogs), 20

ventricular muscle, anthopleu-rim-A-induced prolongation

of action potential of (guineapigs), 479

Hemodynamics, of kidney, effect

of phenytoin (dogs), 304Hemorrhage, nonhypotensive,

captopril-induced renal vase-

dilatation after (dogs), 104Henderson, G. L., see Rendig, S.

V., 259

Henry, D. P., see Lappe, R. W.,443

Herchuelz, A., Thonnart, N., Car-pinelli, A., Sener, A. and Ma-laisse, W. J.: Regulation ofcalcium fluxes in rat pan-

creatic islets: The role of K�conductance, 213

Heroin (diacetylmorphine), hy-drolysis by serum cholines-terase (man), 1

Hester, T. J., see Cooper, 127Hexamethonium, transport from

cerebrospinal fluid (rabbits),563

Hiller, J. M., see Howells, R. D.,60

Hilton, J. G.: Effects of alpha ad-renergic blockade, combinednicotinic and musarinic gan-

glion blockade and spinal an-esthesia upon norepineph-

rime depression of gangliontransmission in the dog, 522

Histamineeffect on response and sensitiv-

ity oflung during ontogenesis(guinea pigs), 426

influence on vasodilationcaused by arterial occlusionor heavy exercise (dogs), 533

role in centrally mediated ef-fects of ouabain (cats), 552

Ho, W. K. W., see Shibata, S., 357

Hoffer, B. J., see Marwaha, J.,606

Hoffmann, I. S. and Cubeddu, LX.: Presynaptic effects of 2-

aminotetralins on striatal do-paminergic neurons, 486

Holl, J. E., see Tackett, R. L.,552

Holohan, P. D. and Ross, C. P.:Mechanisms of organic cat-ion transport in kidneyplasma membrane vesicles: 1.

Countertransport studies,

191

Holtzman, S. G., see Teal, J. J.,369

Hong, J. S., see Govom, S., 413

Honig, C. R., see Daniel, A., 533Howells, R. D., Groth, J., Huller,

J. M. and Simon, E. J.: Opiatebinding sites in the retina:Properties and distribution,60

Hummel, R. G., see Bois, R. T., 53Hunt, C. A. and Jones, R. T.: Tol-

erance and disposition of te-trahydrocannabinol in man,

35

Hydralazine, effect on vascularfunction (rats), 279

Hydrocortisone, effect on cyclicAMP response of lympho-cytes, role in potentiation ofadenylate cyclase (man), 469

llfl-Hydroxydehydrogenase, sat-

uration, effect on predniso-lone clearance (dogs), 287

6-Hydroxydopamine, effect on at-pha-1 adrenergic receptors inheart (rats), 176

5-Hydroxytryptamine (see Sero-tonin)

Hypertension, effects of minoxidiland hydralazine (rats), 279

Ibuprofen

effects on coronary arterythrombosis and myocardial

ischemia (dog), 271

effect on survival from endo-toxic shock (rat), 160

Ileum, smooth muscle, presynap-tic inhibition by purine nu-cleotides, effect of meth-ylxanthines (guinea pigs),704

Imamura, R. and Fujimoto, J. M.:Site of action of dehydrocho-late in inhibiting the biiary

excretion of morphine in theisolated in situ perfused ratliver, 116

Imamura, T. and Fujimoto, J. M.:A new mode ofaction of SKF525-A on morphine disposi-tion studied by segmentedretrograde intrabiiary injec-

tion (SRI!) in the isolated insitu perfused rat liver, 122

Imamura, T. and Fujimoto: Tran-sit patterns of marker com-

pounds given by segmentedretrograde intrabiliary injec-tion (SRI!) in the isolated insitu perfused rat liver, 110

Inflammation, pleural, 3 day, newmodel of macrophage accu-mulation (rats), 588

Insulin, release, involvement ofalpha-2 adrenergic receptorsin regulation of (rats), 226

Inui, J., see Hashimoto, K., 4794-Ipomeanol, conjugation with

glutathione (rats), 97

Ishida, H., see Hats, F., 716

Ishida, U., see Shibata, S., 357

l-Isoproterenol, effect on response

and sensitivity oflung duringontogenesis (guinea pigs), 426

Johanson, C. E., see Smith, Q. R.,673

Jones, R. T., see Hunt, C. A., 35

KalisZak, J. E., see Griffiths, R.R, 649

Karaki, H. and Weiss, G. B.: Dis-

sociation of varied actions ofnorepinephrine on Ca uptakeand release at different sitesin rabbit aortic smooth mus-

cle, 363Karczmar, A. G., see Dun, N. J.,

455

Kato, R., see Nakadate, T., 226

Katsuragi. T. and Su C.: Purinerelease from vascular adre-nergic nerves by high potas-sium and a calcium iono-phore, A23187, 685

Kauker, M. L., see Barr, J. G., 172Khazan, N., see Lukas, S. E., 382Kheifets, J., see Ackerman, N.,

588Kidney

absorption of fluid and 5,5-di-methyl-2,4-oxazolidinedione,

comparative action of acet-azolamide and parathyroidhormone (rats), 557

clearance of digoxin (dogs), 681gentamicin uptake by (rabbits),

390hemodynamics and renin

release, effect of phenytoin(dogs), 304

medullary cells, effect of argi-nine vasopressin and analogson synthesis of prostaglandinE2 by (rat), 15

metabolism of benzidine byprostaglandin-mediated pro-cess in (rabbits), 401

nephrotoxicity of cephalospo-iins (rabbits), 186

plasma membrane vesicles, or-ganic cation transport in(dogs), 191

role of norepinephrine andphenoxybenzamine in regu-lation of fluid absorption in(rats), 65

tubular secretion of norepi-nephrine (rabbits), 443

urinary excretion of prostaglan-din E2, influence of deoxycor-ticosterone pretreatment oneffect of SQ-20881 (rat), 172

vasodilation induced by capto-

pril after nonhypotensive

hemorrhage (dogs), 104Kinetics (see also Pharmacoki-

netics)of oxazepam, effects of age and

sex (man), 86

quinidine, effect of plasma pro-tein binding (rabbits), 165

Kirz, H., see Fichtl, B., 248Kizer, J. S., see Greeley, G. H.,

545

Knodell, R G., Brooks, D. A., Al-len, H. C. and Kyner, W. T.:Alterations in tentobarbital

and meperidine pharmacoki-netics induced by bile ductligation in the rat, 619

K#{246}592, (+)- and (-)-, effect onaction potential in papillarymuscles (guinea pigs), 507

Kohli, J. D., see Listinaky, J. J.,662

Kolibash, A. J., see Unverferth,

D. V., 527Kuczenski, R.: Amphetamine-

haloperidol interactions onstriatal and misolimbic tyro-sine hydroxylase activity and

dopamine metabolism, 135Kupersmith, J. and Cohen, R:

Differing electrophysiologiceffects of slow response in-hibiting agents manganese

and verapamil on ischemic,infarcted and normal tissuein situ, 394

Kyner, W. T., see Knodell, R G.,619

La Du, B. N., see Lockridge, 0., 1

Lai, R.-T., see Hats, F., 716Laliey, P. M.: Inhibition of de-

presser cardiovascular re-

flexes by a derivative of y-aminobutyric acid (GABA)and by general anestheticswith suspected GABA-mi-

metic effects, 418Lanman, R C. and Schanker, L

S.: Transport of choline outof the cranial cerebrospinal

1980 Index 727

fluid spaces of the rabbit,563

Lanthanum, effects on [‘251]cal-modulin binding in striatum

(rat), 28

Lappe, R. W., Henry, D. P. andWillis, L. R.: Mechanism ofrenal tubular secretion ofnorepinephrine in the rabbit,443

Laskowski, M. B., see Bois, 53Lou, C., see Bartolome, J., 596Lau, Y. and Gnegy, M.: Effects of

lanthanum and trifluopera-zine on 125! calmodulin bind-ing to rat striated particulates,

28

Lee, I. P. and Suzuki: Induction ofaryl hydrocarbon hydroxy-lase activity in the rat pros-tate glands by 2,3,7,8-tetra-chlorodibenzo-p-dioxin, 601

Leier, C. V., see Unverferth, D. V.,

527

Levin, R. M., Shofer, F. S. andWein, A. J.: Estrogen-in-duced alterations in the au-tonomic responses of the rab-bit urinary bladder, 614

Levy, M. N., see Masuda, Y., 20Lichtenstein, L. M., see Marone,

G., 469

Liebson, I., see Griffiths, R. R.,649

Lietman, P. 5., see Lipsky, J. J.,390

Lindmar, R., Loffelholz, K.,Weide, W. and Witzke, J.:Neuronal uptake of cholinefollowing release of acetyl-choline in the perfused heart,710

Lipsky, J. J., Cheng, L., Sacktor,B. and Lietman, P. 5.: Gen-tamicin uptake by renal tu-bale brush border membranevesicles, 390

Listinsky, J. J., Kohli, J. D. andGoldberg, L. I.: Consistentunmasking of dopamine-in-duced dilation of the caninefemoral vascular bed, 662

Liver

action of SKF 525-A on mor-phine disposition in, studiedby segmented retrograde in-trabiiary injection (rat), 122

isolated perfused, effect of es-tradiol-171.? on metabolism

and biiary excretion ofphenytoin in (rats), 71

microsomes, formation of glu-

tathione and 4-ipomeanolconjugates (rats), 97

site of action in inhibiting bii-

ary excretion of morphine(rat), 116

transit patterns of marker corn-pounds given by segmentedretrograde intrabiliary injec-tion (rats), 110

Lock, J. E., Coceani, F., Hamilton,F., Greenaway-Coates, A.and Olley, P. M.: The pul-monary vascular effects ofthree prostaglandin 12 ana-

logs in conscious newbornlambs, 156

Lockridge, 0., Mottershaw-Jack-son, N., Eckerson, H. W. and

La Du, B. N.: Hydrolysis ofdiacetylmorphine (heroin) byhuman serum cholinesterase,

Loffelholz, K., see Lindmar, R.,710

Lucchesi, B. R., see Romson, J.

L., 271

Lukas, S. E., Moreton, J. E. andKhazan, N.: Comparative

study of the electroencepha-

lographic and behavioral ef-fects of l-a-acetylmethadol(LAAM), two of its metabo-

lites and morphine and meth-

adone in the rat, 382

Lungartery, prostacyclin and throm-

boxane A2 synthesis by (rab-bits), 240

microsomes, formation of glu-

tathione and 4-ipomeanolconjugates (rats), 97

parenchymal strips, effects of

vaccination with Haemophi.lus influenzae on adrenocep-tor function of (guinea pigs),

691response and scnsitivity to ag-

onists during ontogenesis(guinea pigs), 426

vascular effects of prostaglan-din 12 analogs (lambs), 156

Lymphocytes, effect of hydrocor-

tisone on cyclic AMP re-sponse of (man), 469

MacDonald, J. S., see Olson, R.D., 450

Macrophage accumulation, 3 daypleural inflammation as newmodel of (rats), 588

Magorien, R. D., see Unverferth,

D. V., 527Malaisse, W. J., see 213

Manganese, electrophysiologic ef-

fect on ischemic, infarcted

and normal tissue of heart(dogs), 394

Mannitol, segmented retrogradeintrabiliary injection in liver,

transit patterns of (rats), 110

Manders, W. T., Vatner, S. F. andBraunwald, E.: Cardioselec-tive beta adrenergic stimula-tion with prenalterol in theconscious dog, 266

Marone, G., Lichtenstein, L. M.and Plaut, M.: Hydrocorti-sone and human lympho-cytes: Increases in cyclic

adenosine 3’:S’-monophos-phate and potentiation of

adenylate cyclase-activatingagents, 469

Martinez, S., see Ackerman, N.,

588Marwaha, J., Palmer, M. R.,

Woodward, D. J., Hoffer, B.

J. and Freedman, R.: Electro-physiological evidence forpresynaptic actions of phen-

cyclidine on noradrenergictransmission in rat cerebel-lum, 606

Mason, D. T., see Rendig, S. V.,

259

Masuda, Y. Matsuda, V. and

Levy, M. N.: The effects ofcocaine and metanephrine onthe cardiac responses to nor-

epinephrine infusions, 20Matsuda, Y., see Masuda, Y., 20

Maxwell, R. A., see Cooper, 127

McGillard, K. L. and Olsen, G. D.:Stereospecific radioimmu-

noassay of l-a-acetylmetha-

dol (LAAM), 205McDonald, F. D., see Migdal, S.

D., 304

McGivney, W. T., see McMillan,D. E., 9

McMillan, E. D., McGivney, W.T. and Hardwick, W. C.: Ef-fects of drugs on behavior in

rats maintained on morphine,methadone or pentobarbital,9

McMillen, B. A., German, D. C.,

Sanghera, M. K., Warnack,

W. and Shore, P. A.: Pimo-zide: Delayed onset of action

at rat striatal pre- and post-

synaptic dopamine receptors,

150

Meacham, J. A., see Unverferth,

D. V., 527

Membrane repolarization time, inisolated Purkinje fibers, pro-pranolol effects on (dogs), 539

Meperidine

comparative cardiac contractileactions with morphine, pen-

tazocine, fentanyl, metha-

done and l-a-acetylmethadol(LAAM) (cats), 259

pharmacokinetics, effects ofbile duct ligation (rats), 619

Metabolismand biiary excretion of pheny-

tom in isolated perfused liver,

effect of estradiol-17/3 (rats),

71

arachidonic acid, in pulmonaryartery (rabbit), 240

dopamine, brain, amphet-amine-haloperitol interac-

tions on (rats), 135

dopamine, effects of yohimbine

(rats), 494dopamine, in neostriatum, pre-

synaptic effects of 2-amino-

tetralins (rats), 486of benzidine by prostaglandin-

mediated process in kidney(rabbits), 401

of ethanol, effects of castration

and morphine (rats), 317

of tetrahydrocannabinol (man),35

protein, in liver, effect of mirex(rats), 82

Metanephrine, effects on cardiacresponses to norepinephrine

(dogs), 20

Methadonecomparative cardiac contractile

actions with morphine, me-

peridine, pentazocine, fen-tanyl and 1-a-acetylmethadol

(LAAM) (cats), 259effects on behavior (rats), 9effects on respiration and yen-

tilation (goats), 45electroencephalographic and

behavioral effects (rats),3.82

Methionine enkephalin, binding

sites in retina (rats, cows,

toads, skates), 60

Methylisobutyixanthine, effect in

embryonic ventricle, musca-

rinic antagonism of (chick),

348

N ‘-methylnicotinamide, trans-

port from cerebrospinal fluid

(rabbits), 563

Methylphenidate, effects on

growth and endocrine func-tion (rats), 545

Methylxanthines, effect on pre-

synaptic inhibition of ileum

smooth muscle induced by

purine nucleotides (guineapigs), 704

Microtubules, interaction with

calcium in action of cyclic

AMP on urinary bladder(toads), 254

Midzenski, M., see Brink, C., 426Migdal, S. D., Slick, G. L., Abu-

Hamdan, D. and McDonald,F. D.: Phenvtoin, renal func-tion and renin release, 304

Miki, S., see Yuasa, S., 254

Miller, M. S., Gandolfi, J.,Vaughan, R. W. and Bentley,J. B.: Disposition of enflur-ance in obese patients, 292

Mills, E., see Bartolome, 596Mills, E., see Deskin, R., 342

Minoxidil, effect on vascular func-tion (rats), 279

Miram, L, see Ackerman, N., 588

Mirex, effect on protein metabo-lism and catabolism in liver

(rats), 82

Mitochondria, myocardial, effectof dobutamine (man), 527

Miura, Y., see Hashimoto, K., 479

Moncada, S., see Salzman, P. M.,248

Monoamine oxidase, type A, do-pamine-containing neuronsin brain (rats), 461

Montgomery, C., see Vore, M., 71Moreton, J. E., see Lukas, S. E.,

382

Morikawa, Y., see Hats, F., 716

Morphineanalgesia, effects of naloxone

(rats), 626biiary excretion, inhibited by

dehydrocholate (rat), 116

comparison of cardiac contrac-

tile actions with other nar-cotic analgesics and i-a-ace-

tylmethadol (LAAM) (cats),259

disposition in liver, action of

SKF 525-A, studied by seg-mented retrograde intrabili-ary injection (rat), 122

effects on antinociceptine ac-

728 Index Vol. 215

tion at spinal and supraspinal

sites (rats), 633

effects on behavior (rats), 9

effects on liver alcohol dehydro-genase and metabolism ofethanol (rats), 317

electroencephalographic and

behavioral effects (rats), 382stereoselective stimulus effects

(monkey), 369tolerance to effects on intestinal

motility (dogs), 515

Mottershaw-Jackson, N., see

Lockridge, 0., 1

Muraki, T., see Nakadate, T., 226Muscarinic blockade, effect on

norepinephrine ganglion de-

pression (dogs), 522

Muscleairway, contraction/relaxation,

role of cyclic nucleotides(guinea pigs), 434

airway, response and sensitivity

to agonists during ontogen-esis (guinea pigs), 426

cardiac ventricular, anthopleu-rim-A-induced prolongationof action potential of (guinea

pigs), 479

papillary, effects of beta adre-nergic blockers on action po-tential in (guinea pigs), 507

smooth, aortic, norepinephrine

actions on �Ca uptake andrelease in (rabbits), 363

smooth, arterial and vascular,effects of minoxidil and hy-dralazine (rats), 279

smooth, ileum, presynaptic in-

hibition by purine nucleo-tides, effect of methylxan-thines (guinea pigs), 704

tissue, drug binding to (rabbits),248

Myocardial ischemia, effects ofibuprofen (dog), 271

Myocardium, mitochondria, ef-fects of dobutamine (man),

527

Nakadate, T., Nakaki, T., Muraki,T. and Kato, R.: Adrenergicregulation of blood glucoselevels: Possbile involvement

of postsynaptic alpha-2 typeadrenergic receptors regulat-ing insulin release, 226

Nakaki, T., see Nakadate, T., 226Naloxone

binding sites in retina (rats,cows, toads, skates), 60

effects on morphine analgesia(rats), 626

Narcotics (see also specific drug)

Narcotic analgesics (see specificdrug)

Nash, C. B., see Cook, L. S., 198

Nasjletti, A., see Barr, J. G., 172

Neal, R C. and Olsen, G. D.: Theeffects of methadone on res-piration and ventilation inPygmy goats, 45

Nephrotoxicity of cephalosporins(rabbits), 186

Nerveadrenergic stimulation, in iso-

lated atria during chronic tri-cyclic antidepressants (rats),143

adrenergic, vascular, purinerelease by potassium and A-23187 (rabbits), 685

Nerve stimulation, adrenergic, ef-

fects of alpha sympathomi-

metic amines on vasocon-striction by (rabbits), 377

Nervous system, central and anti-

hypertensive effect of pro-pranolol (rats), 221

Neuroleptics, increase of neuro-tenain in brain elicited by(rats), 413

Neuromuscular junction

effects of phenobarbital, etho-suximide and carbamazepine(frogs), 92

pre- and postsynaptic effects ofinhibition of acetycho-linesterase by BW 284c51 at(rats), 53

Neuronsdopamine-containing, brain,

type A monoamine oxidase in(rats), 461

striatal, dopamine-containing,

presynaptic effects of 2-ami-

not.etralins (rats), 486Neurotensin, brain, increase elic-

ited by neuroleptics (rats),413

Neurotransmission, sympathetic,maturation in heart (rats),

342, 596Newman, K., see Cicero, T. J., 317

Nicotinic blockade, effect on nor-epinephrine ganglion depres-sion (dogs), 522

Nijkamp, F. P., see Schreurs, A.J.M.,691

Norepinephrine

actions on �Ca uptake andrelease in aortic smooth mus-cle (rabbits), 363

effects of cocaine and meta-nephrine on cardiac re-sponses to (dogs), 20

ganglion depression, effects ofblocking agents (dogs), 522

renal tubular secretion of (rab-bits), 443

role in regulation of fluid ab-sorption in kidney (rats), 65

Nucleotides, purine, effect ofmethylxanthines on presyn-aptic inhibition of ileumsmooth muscle induced by(guinea pigs), 704

Oates, J. A., see Olson, R D., 450

Obesity, disposition of enfluranein (man), 292

Ochi, R., see Hashimoto, K., 479#{248}ie,S., see Guentert, T. W., 165Okwuasaba, F. K. and Cook, M.

A.: The effect of theophyllineand other methylxanthineson presynaptic inhibition ofthe longitudinal smooth mus-cle of the guinea-pig ileuminduced by purine nucleo-tides, 704

Olley, P. M., see Lock, J. E., 156

Olsen, G. D., see McGillard, K. L.,205

Olsen, G. D., see Neal, R. C., 45

Olson, R. D., MacDonald, J. S.,vanBoxtel, C. J., Boerth, R.C., Harbison, It D., Slonim,A. E., Freeman, R. W. andOates, J. A.: Regulatory roleof glutathione and soluble

sulfhydryl groups in the tox-

icity of Adriamycin, 450

Ontogenesis, response and sensi-tivity of lung to agonist dur-ing (guinea pigs), 426

Opiates (see also specific name)

binding sites in retina (rats,cows, toads, skates), 60

receptor, striatum, agonist/an-tagonist actions on dopami-nergic function (rats), 697

Opioid, receptors, role in stimuluseffects of morphine and cy-clazocine (squirrel), 369

Orita, Y., see Yuasa, S., 254

Ouabaincentrally mediated effects, role

of histamine (cats), 552positive isotropic effect, sodium

dependence of (cats), 569Oxazepam, kinetics, effects of age

and sex (man), 86Oxprenolol, effect on action po-

tential in papillary muscles

(guinea pigs), 507

Oxtytocin, effect on synthesis of

prostaglandin E� by renalmedullary cells (rat), 15

Palmer, M. R., see Marwaha, J.,606

Pancreas islets, role of K� con-ductance in calcium fluxes in(rat), 213

Pappano, A. J., see Biegon, R. L.,348

Parathyroid hormone, action onfluid and 5,5-disnethyl-2,4-ox-azolidinedione absorption byproximal tubule (rats), 557

Patterson, B. A., see Quenzer, L.F., 297

Pentazocine, comparative cardiaccontractile actions with mor-phine, meperidine, fentanyl,methadone and l-a-acetyl-methadol (LAAM) (cats), 259

Pentobarbitaldouble-blind choice comparison

with diazepam and placebo(man), 649

effects on behavior (rats), 9pharmacokinetics, effects of

bile duct ligation (rats), 619Peroutka, S. J. and Snyder, S. H.:

Regulation of serotonin2 (5-HT2) receptors labeled with�1H]spiroperidol by chronictreatment with the antide-pressant amitriptyline, 582

Pharmacokinetics (see also kinet-ins)

dose-dependent, of tocainide

(rats), 231-dynamic analysis of indometh-

acin-furosemide interaction(man), 77

of pentobarbit.aI and meperi-dine, effects of bile duct Iiga-tion (rats), 619

of tocainide, effect of phenobar-bital and SKF 525A (rats),

235Pharmacological effects, compar-

ative studies of d- and l-co-deine (mice, cats), 668

Phencycidine, electrophysiologi-

cal evidence for presynapticaction on noradrenergictransmission in cerebellum

(rats), 606Phenobarbital

effects on neuromuscular tram-mission (frogs), 92

effect on tocainide pharmaco-kinetics (rats), 235

Phenoxybenzamine, role in regu-

lation of fluid absorption inkidney (rats), 65

Phenytoin

inhibition of cyclic GMP accu-mulation in neuroblastomacells by calcium channelblockade (man), 575

metabolism and biiary excre-tion in isolated perfused liver,effect of estradiol-17/1 (rats),71

renal function and resin release(dogs), 304

Pimozide, action at striatal pre-and postsynaptic dopaminereceptors (rats), 150

Pindolol, effect on action poten-tial in papillary muscles(guinea pigs), 507

Placebo, double-blind choicecomparison with pentobarbi-

tal and diazepam (man), 649Plasma

membrane vesicles, kidney, or-ganic cation transport in(dogs), 191

protein binding, effect on quin-

idine kinetics (rabbits), 165Platelets-prostaglandin endo-

peroxide analogs mixture,

possible generation of vase-contracting substance (man,

rabbits, cows), 357Plaut, M., see Marone, G., 469Potassium

in choroid plexus epithelial cell,effect of carbonic anhydrase

inhibitors and acidosis (rats),673

ion, conductance, role in cal-cium fluxes in pancreas islets(rats), 213

role in purmne release from vas-cular adrenergic nerves (rab-bits), 685

Potential (see specific name)

action, in papillary muscles, ef-fects of beta adrenergic

blockers on (guinea pigs), 507

action, of cardiac ventricularmuscle, anthopleurin-A-in-

duced prolongation (guineapigs), 479

positive, from superior cervicalganglion, comparative studyof pharmacological proper-

1980 Index 729

ties of (rabbits, cats, guinea

pigs, rats), 455

transmembrane, effects on os-

dillatory afterpotentials in-duced by acetylstrophanthi-

din in ventricular tissues

(dogs), 332

Prednisolone, clearance at steady

state (dogs), 287

Prenalterol, cardio-selective beta

adrenergic stimulation with

(dogs), 266

Propranololantihypertensive effect in cen-

tral nervous system (rats),

221

effects on membrane repolari-

zation time in isolated Pur-

kinje fibers (dogs), 539

(-)- and (+)-, stereospecific as-

say (man, dog), 643

Prostacyclin, synthesis by pul-

monary artery (rabbits), 240

Prostate glands, induction of aryl

hydrocarbon hydroxylase ac-

tivity by 2, 3, 7, 8-tetrachlo-

rodibenzo-p-dioxin in (rats),

601

Prostaglandin

E2, synthesis by renal medul-

lary cells, effect of arginine

vasopressin and analogs (rat),

15

-mediated process in kidney,

metabolism of benzidine by

(rabbits), 401

E2, urinary excretion, influence

of deoxycorticosterone pre-

treatment on effect of SQ-

20881 (rat), 172

12 analogs, pulmonary vascular

effects of (lambs), 156Prostaglandin endoperoxide ana-

logs-platalets mixture, possi-

ble generation of vasocon-tracting substance (man, rab-

bits, cows), 357

Protein, metabolism and catabo-

lism in liver, effect of mirex

(rats), 82

Pruett, J. K., Walle, T. and Walle,U. K.: Propranolol effects on

membrane repolarization

time in isolated canine Pur-

kinje fibers: Threshold tissue

content and the influence of

exposure time, 539

Punne release, from vascular ad-

renergic nerves by potassium

and A-23187 (rabbits), 685Purkinje fibers, isolated, propran-

olol effects on membrane re-

polarization time in (dogs),

539

Quenzer, L. F., Patterson, B. A.and Volle, R. L.: The cyclicnucleotide content of the rat

superior cervical ganglion,

297

Quinidine, kinetics, effect ofplasma protein binding (rab-

bits), 165

Quintanilla, A. P., see Gibson, T.

P., 681

Raaijrnakers, J. A. M., see

Schreurs, A. J. M., 691Rackham, A., see Wood, P. L., 697

Radioimmunoassay, of a-1-acetyl-methadol (LAAM) (dogs,

rabbits), 205

Rapp, N. S., Zenser, T. V., Brown,

W. W. and Davis, B. B.: Me-

tabolism of benzidine by a

prostaglandin-mediated pro-

cess in renal inner medullary

slices, 401

Receptors

acetylcholine, changes in vas

deferens after denervation

(guinea pigs), 716adrenergic (see Adrenergic re-

ceptors)

dopamine, striatal pre- and

postsynaptic, action of pimo-

zide (rats), 150histamine, in airway muscle

(guinea pigs), 434

opiate, agonist/antagonist ac-

tions on dopaminergic func-

tion in (rats), 697opioid, role in stimulus effects

of morphine and cyclazocine

(squirrel), 369

serotonin2, labeled with [�H]-

spiroperidol, regulation by

amitriptyline (rats), 582

Reigelman, S., see Silber, B., 643

Rendig, S. V., Amsterdam, E. A.,

Henderson, G. L., and Ma-

son, D. T.: Comparative car-diac contractile actions of six

narcotic analgesics: Mor-

phine, meperidine, pentazo-

cine, fentanyl, methadone

and 1-a-acetylmethadol

(LAAM), 259Renin, release from kidney, effect

of phenytoin (dogs), 304

Respiration, effects of methadone

(goats), 45

Retina, opiate binding sites in

(rats, cows, toads, skates), 60

Richard, J. W., see Wood, P. L.,

697

Robinson, K. M. and Yarbrough,J. D.: Liver protein synthesis

and catabolism in mirex-pre-

treated rats with enlarging

livers, 82

Roeski, R. W., see Yamada, S.,176

Romson, J. L., Bush, L. P., Haack,D. W. and Lucchesi, B. R.:The beneficial effects of oralibuprofen on coronary artery

thrombosis and myocardial

ischemia in the conscious

dog, 271

Ross, C. R., see Holohan, P. D.,

191

Rossi, R., see Caputi, A. P., 309

Rudy, T. A., see Yeung, J. C., 626,

633Ruffolo, R. R., Jr., see Cohen, M.

L., 325

Sacktor, B., see Lipsky, J. J., 390

Sada, H. and Ban T.: Effects ofacebutolol and other struc-

turally related beta adrener-

gic blockers on transmem-

brane action potential in

guinea-pig papillary muscles,

507Salbutamol, effect on response

and sensitivity of lung during

ontogenesis (guinea pigs), 426

Salmon, J. A., see Salzman, P. M.,248

Salzamn, P. M., Salmon, J. A.,

and Moncada, S.: Prostacy-

din and thromboxane A2 syn-

thesis by rabbit pulmonary

artery, 240

Sanghera, M. K., see McMillen,

BA., 150

Scatton, B., Zivkovic, B. and De-

dik, J.: Antidopaminergic

properties of yohimbine, 494

Schanker, L. S., see Lanman, R.C., 563

Schreurs, A. J. M., Terpstra, G.

K., Raaijmakers, J. A. M. and

Nijkamp, F. P.: Effects of

vaccination with Haemophi-

lus influenzae on adrenocep-

tor function of tracheal and

parenchymal strips, 691

Segmented retrograde intrabili-

ary injection

in liver, transit patterns of

marker compounds given by

(rats), 110

to study dehydrocholate inhi-

bition of morphine, biiary

excretion (rat), 116

to study SKF 525-A action on

morphine disposition in liver

(rat), 122

Seidler, F. J., see Deskin, R., 342

Seiwell, R., see Chennavasin, P.,

77

Sener, A., see Herchuelz, A., 213

Serotonin2 receptors labeled with

[�HJspiroperidol, effect of

amitriptyline on regulation of

(rats), 582Sex, effect on oxazepam kinetics

(man), 86

Shader, R. I., see Greenblatt, D.

J., 86

Shibata, S., Ho, W. K. W. and

Ishida, U.: Possible genera-

tion of potent vasocontract-

ing substance from prosta-

glandin endoperoxide ana-

logs, human platelets mix-

ture, 357

Shock, endotoxic, effect of ibupro-

fen on survival from (rat), 160Shofer, F. S., see Levin, R. M.,

614

Shore, P. A., see McMullen, B. A.,150

Silber, B. and Riegelman, S.: Ster-eospecific assay for (-)- and(+)-propranolol in humanand dog plasma, 643

Simon, E. J., see Howells, R. D.,60

SKF 525-A

action on morphine disposition

in liver, studied by retrograde

intrabiiary injection (rat),

122

effect on tocainide pharmaco-

kinetics (rats), 235

Slick, G. L., see Migdal, S. D., 304

Slonim, A. E., see Olson, R. D.,

450

Slotkin, T. A., see Bartolome,

596

Slotkin, T. A., see Deskin, R., 342

Small intestine, tolerance to ef-

fects of morphine (dogs), 515Smith, C. B., see Crews, F. T., 143

Smith, D. J., see Demarest, K. T.,

461

Smith, Q. R. and Johanson, C. E.:Effect of carbonic anhydrase

inhibitors and acidosis on

choroid plexus epithelial cellsodium and potassium, 673

Smits, J. F., van Essen, H. and

Struyker-Boudier, A. J.: Is

the antihypertensive effect of

propranolol caused by an ac-tion within the central nerv-

ous system?, 221

Smooth muscle (see Muscle,

smooth)

Snyder, S. H., see Peroutka, S. J.,

582Sodium

dependence of positive mo-tropic effect of cardiac glyco-sides (cats), 569

in choroid plexus epithelial cell,effect of carbonic anhydrase

inhibitors and acidosis (rats),673

Sodium chloride appetite, effectof captopnil (rats), 407

Spinal cord, transection, response

of bladder to bethanechol

after (cats), 500Spinal-supraspinal interaction, ef-

fects of morphine (rats), 633

[3H]Spiroperidol, on regulationby amitriptyline of serotonin2

receptors labeled with (rats),582

SQ-20881, effect on urinary excre-tion of prostaglandin E2, in-

fluence of deoxycorticoster-

one pretreatment (rat), 172

Stereospecific assay, af (-)- and

(+)-propranolol (man, dog),643

Stimulation

adrenergic nerve, in isolated

atria during chronic tricyclic

antidepressants (rats), 143

cardio-selective beta adrenergic

with prenalterol (dogs), 266

Stotland, M., see Wood, P. L.,697

Striatum

amphetamine-haloperidol in-

teractions on (rats), 135

dopaminergic function, actions

of opiate receptor agonists/antagonists (rats), 697

effects of lanthanum and tri-

fuoperazine on {1251]calmo-dulin binding in (rat), 28

pre- and postsynaptic dopa-mine receptors, action of pi-miozide (rats), 150

Struyker-Boudier, A. J., see

Smits, J. F., 221

Study, R. E.: Phenytoin inhibition

730 Index Vol. 215

of cyclic guanosine 3’:5’-

monophosphate (cGMP ac-

cumulation in neuroblastomacells by calcium channelblockade, 575

Su, C.: Potentiative effects of al-

pha agonistic sympathome-metic amines on vasocon-

striction by adrenergic nerve

stimulation, 377

Su, C., see Katsuragi, T., 685Sucrose, segmented retrograde in-

trabiiary infection in liver,

transit patterns of (rats), 110

Sulfhydryl groups, regulatory role

in toxicity of Adriamycin

(mice), 450

Suzuki, K., see Lee, I. P., 601

Svirbely, J. R., see Unverferth, D.

V., 527

Tachycardia, reflex-induced, ef-

fect of brain acetylcholine

(rats), 309

Tackett, R. L. and Holl, J. E.:

Histaminergic mechanisms

involved in the centrally me-diated effects of ouabain, 552

Takamitsu, Y., see Yuasa, S., 254

Takeyasu, K., see Hats, F., 716Teal, J. J. and Holtzman, S. G.:

Stereoselectivity of the stim-

ulus effects of morphine andcyclazocine in the squirrel

monkey, 369

Terpstra, G. K., see Schreurs, A.J. M., 691

Testosterone, role in regulation of

liver alcohol dehydrogenase

and metabolism of ethanol

(rats), 317

2,3, 7,8 - Tetrachlorodibenzo -p-dioxin, induction of aryl hy-drocarbon hydroxylase activ-

ity in prostate glands by(rats), 601

Tetraethylammonium, effect on

calcium fluxes in pancreatic

islets (rat), 213

Tetrahydrocannabinol, toleranceand disposition of (man), 35

Theophylline, effect on presyn-aptic inhibition of ileum

smooth muscle induced by

purse nucleotides (guineapigs), 704

Thonnart, N., see Herchuelz, A.,213

Thor, P. J., see Weisbrodt, N. W.,

515Thrombosis, coronary artery, ef-

fects of ibuprofen (dog), 271

Thromboxane A2, synthesis bypulmonary artery (rabbits),240

Tissues, ventricular, effects of

transmembrane potential onoscillatory afterpotentials in-

duced by acetyistrophanthi-

din in (dogs), 332Tocainide

dose-dependent pharmacoki-

netics (rats), 231

pharmacokinetics, effect of

phenobarbital and SKF 525A(rats), 235

Tolerance, to tetrahydrocannabi-nol (man), 35

Tomolonis, A., see Ackerman, N.,588

Toxicity

digitalis, role of membrane po-

tential (dogs), 332of Adriamycin, regulatory role

of glutathione and sulfhydryl

groups in (mice), 450

Trachea, effects of vaccinationwith Haemophiius influ-

enzae on adrenoceptor func-tion (guinea pigs), 691

Transmission

neuromuscular, effects of phe-

nobarbital, ethosuximide andcarbamazepine (frogs), 92

noradrenergic, in cerebellum,

electrophysiological evidence

for presynaptic actions of

phencyclidine on (rats), 606Tricyclic antidepressant, chronic,

adrenergic nerve stimulationin isolated atna during (rats),143

Trifluoperazine, effects on [‘9]-

calmodulin binding in stria-turn (rat), 28

Trommer, B. A., see Alderdice, M.

T., 92Tune, B. M. and Fravert, D.:

Cephalosporin nephrotoxic-

ity. Transport, cytotoxicity

and mitochondrial toxicity of

cephaloglycin, 186Twiddy, D. A. S., Downie, J. W.

and Awad, S. A.: Response ofthe bladder to bethanecholafter acute spinal cord tran-

section in cats, 500

Tyrosine hydroxylase activity,

brain, amphetamine-haloper-idol interactions on (rats),

135

Unverferth, D. V., Leier, C. V.,

Magorien, R. D., Croskery,R., Svirbely, J. R., Kolibash,A. J., Dick, M. R., Meacham,J. A. and Baba, N.: Improve-ment of human myocardial

mitochondria after dobutam-me: A quantitative ultra-structural study, 527

Vaccination, Haemophilus influ.enzae, effects on adrenocep-tor function of tracheal andparenchymal strips (guineapigs), 691

vanBoxtel, C. J., see Olson, R. D.,450

van Essen, H., see Smith, J. F., 221

Vascular bed, femoral, dopamine-induced dilation (dogs), 662

Vas deferens, changes in cholin-

ergic system after denerva-

tion (guinea pigs), 716Vasoconstriction, by adrenergic

nerve stimulation, effects ofalpha sympathomimetic

amines (rabbits), 377Vasocontracting substance, pos-

sible generation from prosta-glandin-platelets mixture(man, rabbits, cows), 357

Vasodilation

by arterial occlusion or heavyexercise, influence of hista-mine (dogs), 533femoral vascular bed, dopa-mine-induced (dogs), 662

Vasodilatation, renal, after non-hypotensive hemorrhage,

captopnil-induced (dogs), 104

Vatner, S. F., see Manders, W. T.,266

Vaughan, R. W., see Miller, M. S.,292

Vein, jugular, antagonist and ago-nist interactions with beta-iand beta-2 adrenergic recep-tors in (rats), 325

Venkataramanan, R. and Axel-

son, J. E.: Dose-dependentpharmacokinetics of tocain-ide in the rat, 231

Venkataramanan, R. and Axel-

son, J. E.: The effect of phe-nobarbital and SKF 525A ontocainide pharmacokineticsin the rat, 235

Ventilation, effects of methadone(goats), 45

Ventricle, embryonic, muscarinicantagonism of effectsof methylisobutylxanthine(chick), 348

Verapamil, electrophysiologic ef-fect on ischemic, infarctedand normal tissue of heart

(dogs), 394

Voile, R. L., see Quenzer, L. F.,297

Vore, M. and Montgomery, C.:The effect of estradiol-17$treatment on the metabolismand biiary excretion ofphenytoin in the isolated per-

fused rat liver in vivo, 71

Waile, T., see Pruett, J. K., 539Walle, U. K., see Pruett, J. K., 539Warnack, W., see McMillen, B.

A., 150

Watanabe, T., see Yuasa, S., 254

[3H]WB41O1, use for characteri-

zation of alpha-i adrenergicreceptors in heart (rats), 176

Weide, W., see Lindmar, R., 710

Wein, A. J., see Levin, R M., 614Weisbrodt, N. W., Thor, P. J.,

Copeland, E. M. and Burks,T. F.: Tolerance to the effectsofmorphine on intestinal mo-

tiity of unanesthetized dogs,

515Weiss, G. B., see Karaki, H., 363

Whitmore, W. L., see Deskin, R.,

342

Wiggins, J. R. and Bentohila, J. J.:Sodium dependence of thepositive inotropic effect ofcardiac glycosides, 569

Wiley, K. S., see Cohen, M. L.,325

Willis, L R., see Lappe, R. W.,

443Wise, W. C., Cook, J. A., Eiler, T.

and Halushka, P. V.: Ibupro-fen improves survival fromendotoxic shock in the rat,160

Witzke, J., see Lindmar, R, 710Wong, P. C. and Zimmerman, B.

G.: Mechanism of captopril-induced renal vasodilatationin anesthetized dogs afternonhypotensive hemorrhage,104

Wood, P. L, Stotland, M., Rich-ard, J. W. and Rackham, A.:Actions of mu, kappa, sigma,delta and agonist/antagonistopiates on striatal dopami-nergic function, 697

Woodward, D. J., see Marwaha,J., 606

Yamada, S., Yamamura, I. andRoeski, W. P.: Characteriza-tion of alpha-i adrenergic re-ceptors in the heart using[3H]WB41O1: Effect of 6-hy-droxydopamine treatment,176

Yamamura, H. I., see Yamada, S.,176

Yang, H.-Y. T., see Govoni, S.,

413Yarbrough J. D., see Robinson, K.

M., 82Yeung, J. C. and Rudy, T. A.:

Sites of antinociceptive ac-tion of systemically injectedmorphine: Involvement of su-

praspinal loci as revealed byintracerebroventricular in-jection of naloxone, 626

Yeung, J. C. and Rudy, T. A.:Multiplicative interaction be-tween narcotic agonisms ex-pressed at spinal and supra-spinal sites of antinociceptiveaction as revealed by concur-rent intrathecal and intra-cerebroventricular infections

of morphine, 633Yohimbine, antidopaminergic

properties (rats), 494

Yoshida, H., see Hats, F., 716

Yuasa, S., Takamitsu, Y., Mild, S.,

Orita, Y., Abe, H. and Watan-abe, T.: Interaction of cal-cium and microtubules in theaction of cyclic AMP on thetoad urinary bladder, 254

Zenser, T. V., see Rapp, N. S., 401

Zimmerman, B. G., see Wong, P.C., 104