INDEX

Volume 264, January-March, 1993

A-75200, actions on norepinephrine uptakeand release, bovine adrenal chromaf-fin cells, 1206

Aagaard, P. J., see Mckinney, M, 74Aalkjaer, C., see Juul, B., 1234Abdel-Rahman, A. A., see El-Mas, M. M.,

1198Abecarnil, long-term treatment, no induc-

tion of diazepam-like dependence(mice), 1395

Abels, B. C., Branch, R. A. and Sabra, R.:Interaction between thromboxane A2and angiotensin II in postischemicrenal vasoconstriction in dogs, 1285

Ableitner, A., see Bals-Kubik, R., 489Acetohexamide reductase, hormonal regu-

lation, postnatal development andsex-related differences, liver and kid-ney (rats), 166

Acetylcholineneurally mediated action of leukotrienes,

ion transport, distal colon (guineapigs), 384

presynaptic cholinergic actions, DuP 996

(rats), 910striated dopaniine and, quinpirole, com-

parisons with B-HT 920 and SND919, 1344

tachykinins and, ascending enteric reflex

contraction, propagation of excita-tion (guinea pigs), 391

Acetylcholinesterasegastroprokinetic activity of nizatidine

(dogs, rats), 152

pyridostigmine and HI-6, comparison ofantidote protection, soman, 1085

Acidosis, glycolysis and glucose oxidation,fatty acids, aerobic reperfusion of is-chemic hearts (rats), 135

Acquired immunodeficiency syndrome, dis-tributional transport kinetics of zi-dovudine, plasma, brain extracellular

fluid/cerebrospinal fluid (rabbits),

899AD-5423, pharmacological profile (mice,

rats), 158

Adachi, T., see Fujita, S., 226Adenosine

endogenous, manipulation in prepiriformcortex, seizure susceptibility (rats),

1415

-stimulated contraction, lack of cyclo-ox-ygenase involvement, nonpregnant

myometrium (guinea pigs), 1033Adenosine triphosphate

contractile effects of nucleotides, trachea(guinea pigs), 210

modulation of low affinity binding sites,nucleotides and glibenclamide, brain(rata), 701

related nucleotides and, tone, mesenteric

resistance arteries (rats), 1234Adenylate cyclase

ethanol-induced desensitization, adeno-

1492

sine receptor, GTP-binding proteins,

977

methoxy-chroman derivatives, agonist

properties, central 5-HT1A receptors(rats), 863

Adenylyl cyclaseantisense oligodeoxynucleotide to mes-

senger RNAs, seven transmembrane

spanning regions, cerebellar granulecells (rats), 423

chronic etorphine-induced sensitization,buprenorphine prevention and rever-sal, neuroblastoma cells, 368

cyclic AMP accumulation, bicarbonate-induced sensitization, astrocytomacells (humans), 1211

Adler, M. W., see Bussiere, J. L., 591Adrenal chromaffin cells

actions of A-7500, norepinephrine uptakeand release (cattle), 1206

cholinergic agonist- and K�-induced cy-tosolic-free Ca’’ signals, effects ofcaffeine (pigs), 770

Adrenalectomy, kinetics of drug action in

disease states, phenobarbital andtheophylline, pain sensitivity (rats),859

Adrenal medulla, modulation of inhibition,bradykinin-induced plasma extrava-sation, intrathecal nicotine (rats),

839

Adrenoceptorsalpha, morphine-induced suppression,

splenocyte natural killer activity,1179

alpha-iacute and chronic hypertensive mech-

anism, ketanserin (rats), 129control of cataplexy, narcolepsy (dogs),

1079

alpha-2characterization of subtypes, brain (hu-

mans), 967

dexmedetomidine, ST-91 and cloni-dine, 327

discrimination and pharmacologicalcharacterization, I2-imidazoline sites(humans, rats),1187

inner medullary collecting duct cells,kidney (rabbits), 879

mu opioid, enteric nerves (guinea pigs),375

rauwolscine, contraction in mesentericartery (dogs), 201

beta-i and beta-2, coupling to cyclic AMPsystem, connecting tubules of neph-

ron (rabbits), 105

AF64A, lesions of striatum, ipsilateral no-tations, D2 dopamine agonists (mice),824

AF-DX 116, autoradiographic mapping, M3

muscarinic receptors, brain (rats),415

Agingr-aminobutyric acid-induced depression,

ethanol effects, cerebellar Purkinje

neurons(rats),951decreased sensitivity to cAMP, genera-

tion, memory splenic cytotoxic T-lymphocytes, 1381

Airway, bradykinin effects in tracheal epi-thelial cells, mediation through B2

kinin receptor, inhibition by Hoe 140(guinea pigs), 1124

Aita, H., see Ueki, S., 152Alaoui-Jamali, M. A., Schecter, R. L., Rus-

turn, Y. M., Centurioni, M. G., Leh-

nert, S. and Batist, G.: In vivo rever-sal of doxorubicin resistance by a new

tiapamil analog Roll-2933, 1299

Alcohol, exposure, two-step mechanism, cy-tochrome P450 CYP 2E1 induction

(rats), 944Aldosterone, hormonal and cardiovascular

effects, losartan (monkeys), 6Alfentanil

-induced antinociception, fl-funaltrexam-me and naloxonazine, muscle rigidity(rats),739

respiratory depressant effects, apparentpA2 analysis (monkeys), 145

Alkylating agents, multiple muscarinic re-ceptor subtypes, activation of phos-pholipase C, brain cortical mem-branes (rats), 521

Alzheimer’s disease, pharmacological char-acterization, hippocampal musca-rinic autoreceptor (rats), 74

Amenta, F., see Ricci, A., 431

Amico, M. C., see Valeri, P., 1028Amidines, bis(5-amidino-2-benzimidazo-

lyl)methane, reversible inhibitors,mast cell tryptases (dogs), 676

Amiloridebis(5-amidino-2-benzimidazo-

lyl)methane, reversible inhibitors,mast cell tryptases (dogs), 676

contractile effects of nucleotides, trachea(guineapigs),210

relaxant effects of nucleotides, trachea

(guinea pigs), 217synthesis of dopamine in kidney, role of

sodium (rats), 4062-Amino-4,5-(i,2-cyclohexyl)-7-phospho-

noheptanoic acid, discriminative

stimulus, pharmacological specificity(rats), 845

Amino acidsendogenous excitatory, outflow of dopa-

mine, nucleus accumbens (rats), 289excitatory, agonists, dipsogenic effects

(pigeons),918

Aminoalkylindole, binding in cerebellum

(rats), 1352-y-Aminobutyric acid, modulation of �S-

TBPS binding, bicuculline-producedregional differences, cerebellum andcortex (mice), 638

r-Aminobutyric acid, -induced depressions,

1993 Index 1493

ethanol effects, cerebellar Purkinjeneurons (rats), 951

Aminohydroxybutane bisphosphonate,clenbuterol and, prevention of bonechanges, retardation of muscle atro-phy (rats), 1071

Aminophylline, isozyme-selective phospho-diesterase inhibitors, pulmonary an-tiallergic and bronchodilator effects(guinea pigs), 609

4-Aminopyridine, block of transient out-ward K� current, ventricular myo-cytes (rats), 1450

5-Aminosalicylic acid, epidermal growthfactor, experimental colitis (rats),

984Amoroso, S., Sensi, S., Di Renzo, G. and

Annunziato, L.: Inhibition of theNa�-Ca� exchanger enhances an-

oxia and glucopenia-induced [3H] as-partate release in hippocampal slices,515

Amphetaminerole of forebrain, responsiveness of nigro-

striated dopamine neurons, dopamineagonists (rats), 616

sensitization, autoreceptor subsensitivity,enhanced dopamine release (rats),249

d-Amphetamine, triazolam discrimination,

selectivity and sensitivity, novel-re-sponse procedure (humans), 360

Amphotericin B, synthesis of dopamine in

kidney, role of sodium (rats), 406Analgesia, thermal antinociception, cloni-

dine, dexmedetomidine and xylazine(monkeys), 762

Anesthetics, trichloroethanol-potentiated

synaptic transmission, mediation byGABAA receptors, hippocampal neu-

rons, 1097Angiogenesis, inhibitor TNP-470, antitu-

mor effects, VX-2 carcinoma (rab-bits), 469

Angiotensin converting enzyme, neurogenicplasma extravasation, nasal mucosa,peptidase inhibitors (rats), 509

Angiotensin IIdistinct signal transduction pathways,

gastric smooth muscle (guinea pigs),958

hormonal and cardiovascular effects, lo-sartan (monkeys), 6

inhibitory effects of DuP 753 and EXP3174, hindquarters vascular bed(cats), 1104

renal microvascular actions of YM435(rats), 1154

thromboxane A2 and, postischemic renalvasoconstriction (dogs), 1285

Annunziato, L., see Amoroso, S., 515Anoxia, inhibition of Na�-Ca� exchanger,

glucopenia-induced aspartate release,

hippocampal slices (rats), 515Antibiotics, macrolide, potent inhibitory ef-

feet, mono-N-dealkylation metabo-lism of disopyramide (humans), 1425

Antibodies, D3 dopamine receptor, pharma-cologic properties, development ofantibodies (rats), 1002

Antibody response, gallium arsenide-in-duced suppression, reversal, mixeddisulfide metabolite of meso-2,3-di-mercaptosuccinic acid (mice), 695

Anticonvulsant agents, felbamate, neuro-

protectant action, strychnine-insen-

sitive glycine receptors, 1248

Antidepressant, -like effects of rolipram, be-havior, differential reinforcement oflow response rate (rats), 1168

Antimuscarinic agents, differential effects,intestinal motility (dogs), 789

Antinatriuresis, renal nerve stimulation-in-duced, suppression by TMB-8 (dogs),117

Antinociceptionalfentanil-induced, �3-funaltrexamine and

naloxonazine, muscle rigidity (rats),739

chronic spinal infusion, dexmedetomi-dine, ST-91 and clonidine, 327

thermal, clonidine, dexmedetomidine andxylazine (monkeys), 762

Antisense oligodeoxynucleotide, messenger

RNAs encoding receptors, seventransmembrane spanning regions,cerebellar granule cells (rats), 423

Antrum, motility, cisapride and 5-hydroxy-

tryptamine (dogs), 79Anxiety

benzodiazepine withdrawal, conflicting

evidence regarding efficacy, ondan-setron(rats), 622

long-term treatment with abecarnil, noinduction of diazepam-like depend-ence (mice), 1395

Ao, S., see Sogabe, K., 1040Aorta

baroreceptors, ethanol-induced impair-

ment, baroreflex control (rats), 1198metabolic activation of glyceryl trinitrate,

lack of involvement of cytochrome P-450 (rabbits), 1432

Apomorphine, impairment of latent learn-ing (mice), 122

Apoproteinchronic alcohol exposure, two-step mech-

anism, cytochrome P450 CYP 2E1induction (rats), 944

chronic intragastric ethanol infusion, ep-isodic ethanol excretion (rats), 938

Apseloff, G., Girten, B., Walker, M., She-

pard, D. R., Krecic, M. E., Stern, L.

S. and Gerber, N.: Aminohydroxy-

butane bisphosphonate and clenbu-terol prevent bone changes and re-tard muscle atrophy, respectively in

tail-suspended rats, 1071Arachidonic acid

release, Bi and B2 kinin receptors, supe-

nor mesenteric artery smooth musclecells (rabbits), 930

twitch tension, phrenic nerve-diaphragm(rats),1311

Archer, S., see Jiang, Q., 1021Arentzen, C., see Jia, H., 1275Arneklo-Nobin, B., see Bodelsson, M., 709Arneson-Rotert, L. J., see Toews, M. L.,

1211Arrigoni, J., see Nishino, S., 1079Arsenic, gallium arsenide-induced suppres-

sion of antibody response, reversal,

mixed disulfide metabolite of meso-2,3-dimercaptosuccinic acid (mice),695

Arterycoronary

cocaine sensitization, drug-inducedspasm (cattle), 1132

pharmacological analysis of vasodila-

tion, extracellular adenosine 3 ‘ ,5 ‘ -

cyclic monophosphate (dogs), 1253serotonin-induced contraction, ergo-

lines (pigs), 193thrombolysis, heparin/aspirin/Ro 43-

5054 (dogs), 501vasomotor responses, NG�monomethyl�

L-arginine and Nw nitro-L-argininemethyl ester, 265

mesenteric, induction of contraction by

rauwolscine, precontraction with

KC1 and endothelin-1 (dogs), 201mesenteric resistance, tone of, effects of

ATP and related nucleotides (rats),1234

neurokinin A derivatives, agonist and an-tagonist properties, C-terminal ami-

dation (guinea pigs, rabbits, hamster,rats), 17

superior mesenteric, Bi and B2 kinin ne-ceptors, smooth muscle cells (nab-

bits), 930tail, acute effects of nicotine, mesenteric

vasculature (rats), 1305

Arthritis

adrenal medullary modulation, bradyki-

nm-induced plasma extravasation,intrathecal nicotine (rats), 839

repression of drug-metabolizing enzymes,interleukin lfl (rats), 1012

Asano, Y., see Homma, S., 105Asante, N. K., see Winn, M. J., 265

Aspartatedistinct actions of endogenous excitatory

amino acids, outflow of dopamine,nucleus accumbens (rats), 289

glucopenia-induced release, inhibition ofNa�-Ca� exchanger, hippocampal

slices (rats), 515Aspirin, coronary artery reperfusion and

reocclusion, thrombolysis, tissue-type plasminogen activator (dogs),501

Asthma, pulmonary antiallergic and bron-chodilator effects, isozyme-selectivephosphodiesterase inhibitors (guineapigs), 609

Astrocytoma, bicarbonate-induced sensiti-zation, cyclic AMP accumulation(humans), 1211

Ataxia, behavior and pharmacokinetic

study, phenylcyclohexylethylamineand its metabolite (rats), 1401

Atrial cells, single, lidocaine block, sodiumchannels (humans), 1275

Atrial natriuretic factor, alteration of neu-rotransmission, guanylate cyclase-coupled receptors, vas deferens (nab-

bits), 1227

Atnopine, comparison of antidote protectionagainst soman, pyridostigmine, HI-6and acetylcholinesterase, 1085

Autonomic nervous system, ileum, nitric ox-ide synthase (dogs), 234

Autoradiographylocalization of dopamine D1 receptors,

kidney (humans), 431mapping of M3 muscarinic receptors,

brain (rats), 415

quinpirole binding, dopamine D2 and D3receptors, brain and pituitary gland(rats), 991

Autoreceptorshippocampal muscaninic, pharmacologi-

cal characterization (rats), 74

1494 Index Vol. 264

subsensitivity, enhanced dopamine re-lease, amphetamine sensitization(rats), 249

Bacci, E., see Caughey, G. H., 676Bacci, E., see Petersson, G., 509Backer, C., see Jia, H., 1275Baculovirus, D3 dopamine receptor, phar-

macologic properties, development ofantibodies (rats), 1002

Badger, T. M., Crouch, J., Irby, D. andShahare, M.: Episodic excretion ofethanol during chronic intragastricethanol infusion in the male rat: Con-

tinuous vs. cyclic ethanol and nu-trient infusions, 938

Badger, T. M., Ronis, M. J. J., Lumpkin, C.K., Shahare, M., Irby, D., Huang, J.,Mercado, C., Thomas, P., Ingelman-Sundberg, M. and Crouch, J.: Effectsof chronic ethanol on growth hor-mone secretion and hepatic cyto-chrome P450 isozymes of the rat, 438

Badger, T. M., see Ronis, M. J. J., 944Badillo, J. M., see Thomas G. R., 67Balasubramaniam, G., Lee, H. S. and Mah,

S. C.: Differences in the acute andchronic antihypertensive mechanism

of action of ketanserin spontaneouslyhypertensive rats, 129

Bals-Kubik, R., Ableitner, A., Herz, A. andShippenberg, T. S.: Neuroanatomicalsites mediating the motivational ef-fects of opioids as mapped by the

conditioned place preference para-digm in rats, 489

Baister, R. L., see Bobelis, D. J., 845Balster, R. L., see Evans, E. B., 726Barium chloride, interaction of sodium and

potassium channel blockers, papil-lary muscle (guinea pigs), 1056

Barnette, M. S., Manning, C. D., Price, W.J. and Barone, F. C.: Initial biochem-ical and functional characterizationof cyclic nucleotide phosphodiester-

ase isozymes in canine colonicsmooth muscle, 801

Baron, S. P. and Woods, J. H.: Dipsogeniceffects of excitatory amino acid ago-nists in pigeons, 918

Barone, F. C., see Barnette, M. S., 801Baroreceptors, aortic, ethanol-induced im-

pairment, baroreflex control of heartrate (rats), 1198

Baroreflex

acute and chronic hypertensive mecha-

nism, ketanserin (rats), 129control of heart rate, ethanol-induced im-

pairment, aortic baroreceptors (rats),1198

Barr, R. L., see Lopaschuk, G. D, 135Barturen, F., see Miralles, A., 1187Basbaum, A. I., see Miao, F. J.-P., 839

Bass, P., see Luck, M. S., 984Bathon, J. M., see Proud, D., 1124Batist, G., see Alaoui-Jamali, M. A., 1299Batt, A.-M., see Ferrari, L., 1012Bealer, S. L.: Histamine releases norepi-

nephrine in the paraventricular nu-cleus/anterior hypothalamus of theconscious rat, 734

Bednar, D. L., see Ferkany, J. W., 256Behavior

autoreceptor subsensitivity, enhanced do-pamine release, amphetamine sensi-tization (rats), 249

differential reinforcement of low responserate, antidepressant-like effects of ro-lipram (rats), 1168

dipsogenic effects, excitatory amino acidagonists (pigeons), 918

effects of 1-phenylbiguanide and m-chlo-rophenylbiguanide (rats), 1440

ipsilateral rotations, AF64A lesions ofstriatum, D2 dopamine agonists

(mice), 824learning and performance, acute effects,

triazolam and lorazepam (humans),1218

pharmacokinetic study and, phenylcy-clohexylethylamine and its metabo-lite(rats), 1401

triazolam discrimination, selectivity andsensitivity, novel-response procedure

(humans), 360Bell, W. E., see Bender, B. S., 1381

Bellan, J. A., see Osei, S. Y., 1104Belt, J. J., see Fedan, J. S., 210, 217Ben-An, Y., see Zini, S., 701

Bender, B. S., Bell, W. B., Taylor, S. andScarpace, P. J.: Decreased sensitivityto cAMP in the In vitro generation

of memory splenic cytotoxic T-lym-phocytes from aged mice: Role ofphosphodiesterase, 1381

Bengtsson, H. -I., see Lundin, S., 783

Bennett, W. F., see Thomas G. R., 67

Benowitz, N. L., see Miao, F. J.-P., 839

Benzodiazepinesacute effects of triazolam and lorazepam,

learning, performance and subjectratings (humans), 1218

chlordiazepoxide, block of two types ofcalcium channels, neuroblastomacells (mice), 22

long-term treatment with abecarnil, noinduction of diazepam-like depend-ence (mice), 1395

withdrawal, conflicting evidence regard-

ing efficacy, ondansetron (rats), 622

6,7-Benzomorphans, properties of epsilonopioid receptor, brain (rats, guineapigs, cows, pigs, chickens), 349

Bergsbaken, C. L., Sommers, S. L. and Law,P. Y.: Effect of forskolin and isobu-tylmethylxanthine on Delta-opioid

receptor activity in neuroblastoma x

glioma NG1O8-15 cells, 1474

Bertz, R. J., see Kroboth, P. D., 1047Bervoets, K., Rivet, J.-M. and Millan, M.

J.: 5-HT1A receptors and the tail flickresponse. IV. Spinally localalized 5-HT1A receptors postsynaptic to sero-toninergic neurones mediate sponta-neous tail-flicks in the rat, 95

Beta blockers, coupling of beta-i and beta-2adrenoceptors, cyclic AMP system,connecting tubules of nephron (rab-bits), 105

B-HT 920, comparisons with quinpirole andSND 919, striatal dopamine and ace-tylcholine release, 1344

Bicarbonate, induction of sensitization,cyclic AMP accumulation, astrocy-toma cells (humans), 1211

Bickel, W. K., Oliveto, A. H., Kamien, J. B.,Higgins, S. T. and Hughes, J. R.: Anovel-response procedure enhancesthe selectivity and sensitivity of atniazolam discrimination in humans,360

Bickel, W. K., see Rush, C. R., 1218Bickford, P. C., see Lin, A. M.-Y., 951Bicuculline, -produced regional differences,

modulation of nS�ThPS binding byvarious agents, cerebellum and cortex(mice), 638

Bidlack, J. M., see Jiang, Q., 1021Bigelow, G. E., see Preston, K. L., 813

Bis(5-amidino-2-benzimidazolyl)methane,related amidines and, reversible in-hibitors, mast cell tryptases (dogs),676

Bladder, initiation of micturition reflex, pe-ripheral role, tachykinins (rats), 1327

Blood-brain barrier, brain extracellularfluid/cerebrospinal fluid, distribu-tional transport kinetics, zidovudine(rabbits), 899

Blood pressure

acute and chronic hypertensive mecha-

nism, ketanserin (rats), 129hormonal and cardiovascular effects, lo-

sartan (monkeys), 6moxonidine, selective ligand, 11-imidazo-

line sites (cattle), 172

BMS 180,291binding and function, platelets (humans),

1387

pharmacological profile (humans, rats,cattle, mice, pigs, guinea pigs), 570

BMY 7378, induction of hypothermia, 5-

HT1A receptor-mediated activity

(rats), 1364

Bobelis, D. J. and Balster, R. L.: Pharma-cological specificity of the discrimi-native stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phos-phonoheptanoic acid, a competitiveN-methyl-D-aspartate receptor an-tagonist, 845

Bodelsson, M., T#{246}rnebrandt, K. and Ar-neklo-Nobin, B.: Endothelial relax-ing 5-hydroxytryptamine receptors inthe rat jugular vein: Similarity with5-hydroxytryptamine1� receptor, 709

Bon, C., see Mounier, C., 1460Bone

calcemic hormone- and growth factor-based resorption, suramin as inhibi-ton (mice), 579

prevention of changes, aminohydroxybu-tane bisphosphonate and clenbuterol,tail-suspended rats, 1071

Borosky, S. A., see Ferkany, J. W., 256

Boundy, V. A., Luedtke, R. R., Gallitano, A.L., Smith, J. E., Filtz, T. M., Kallen,R. G. and Molinoff, P. B.: Expressionand characterization of the rat D3dopamine receptor: Pharmacologicproperties and development of anti-

bodies, 1002Bourguignon, J.-J., see Hechler, V., 1406Bowen, W. D., see Wild, K. D., 831

Bradley, M. E., Kuenzli, K. A. and Buxton,I. L. 0.: Adenosine-stimulated con-traction in nonpregnant guinea pig

myometrium does not involve cyclo-oxygenase, 1033

BradykininBi and B2 kinin receptors, superior mes-

enteric artery smooth muscle cells(rabbits), 930

-induced plasma extravasation, adrenalmedullary modulation, intrathecalnicotine (rats), 839

1993 Index 1495

mediation of effects through B2 kinin re-ceptor, inhibition by antagonist Hoe140 (guinea pigs), 1124

Brainalpha-2 adrenoceptor subtypes (humans),

967antidopaminergic and neuroleptic-like ac-

tivities, ‘y-hydroxybutyrate ligands,

1406autoradiographic mapping, M3 muscarinic

receptors (rats), 415cerebellum and cortex, bicuculline, �S-

TBPS binding (mice), 638

cortical slices, cholinergic modulation,NMDA-evoked norepinephrine re-lease (rats), 282

differential effects of alkylating agents,multiple muscarinic receptor sub-types (rats), 521

discrimination and pharmacological char-acterization, I2-imidazoline sites,

RX821002 (humans, rats), 1187extracellular fluid/cerebrospinal fluid,

distributional transport kinetics, zi-

dovudine (rabbits), 899

modulation of low affinity binding sites,nucleotides (rats), 701

neuroanatomical sites, motivational ef-fects of opioids, conditioned placepreference paradigm (rats), 489

paraventricular nucleus/anterior hypo-thalamus, histamine release, norepi-nephrine (rats), 734

prepiriform cortex, manipulation of en-dogenous adenosine, seizure suscep-

tibility (rats), 1415

properties of epsilon opioid receptor (rats,guinea pigs, cows, pigs, chickens), 349

protein kinase C subtypes, inhibition bylead (rats), 757

quinpirole binding, dopamine D2 and D3receptors (rats), 991

striatal dopamine and acetylcholine re-lease, effects of quinpirole, B-HT 920and SND 919, 1344

synaptosomes, nicotinic receptor func-tion, stimulation of rubidium efflux

(mice),542Brain stem, nucleus tractus solitarius, mod-

ulation of afferent transmission, se-

lective opioid agonists (rats), 795Branch, R. A., see Abels, B. C., 1285Brecht, K. M., see Maxwell, D. M., 1085Brechue, W. F. and Maren, T. H.: Carbonic

anhydrase inhibitory activity and

ocular pharmacology of organic sul-famates, 670

Breese, C. R., D’Costa, A., Ingram, R. L.,Lenham, J. and Sonntag, W. E.:Long-term suppression of insulin-

like growth factor-i in rats after inutero ethanol exposure: Relationship

to somatic growth, 448Breuer, A., see J#{228}rbe,T. U. C., 561Brewer, J. A., see Smolen, T. N., 854

Brien, J. F., see Liu, Z., 1432Broeders, A., see Lundin, S., 783Bronchoalveolar lavage fluid, antigen-me-

diated eosinophilia, IgG1 sensitiza-tion (guinea pigs), 922

Bronchus, neurokinin A derivatives, agonistand antagonist properties, C-termi-nal amidation (guinea pigs, rabbits,

hamster, rats), 17Brooderson, R. J., see Wolf, M. E., 249

Broomfield, J., see Proud, D., ii24Brown, D. R., see Hammerbeck, D. M., 384Brown, D. R., see Traynor, T. R., 61Browning, M. D., see Firestone, J. A., 1206Buckner, C. K., Fishleder, R. I., Conklin, R.,

Will, J. A., Doran, 0. and Graziano,

F. M.: Pharmacologic modulation ofthe influence of the epithelium onimmunologic- and nonimmunologic-induced histamine release and con-traction in guinea pig superfused tra-cheal strips,717

Budipine, neurotransmitter release, centralnervous system tissue (rabbits), 889

Buprenorphineintermittent administration, cocaine self-

administration (monkeys), 530prevention and reversal of expression,

chronic etorphine-induced sensitiza-tion, adenylyl cyclase in neuro-blastoma cells, 368

Burns, L. A., Butterworth, L. F. and Mun-son, A. E.: Reversal of gallium arsen-ide-induced suppression of the anti-body response by a mixed disulfidemetabolite of meso-2,3-dimercapto-succinic acid, 695

Bussiere, J. L., Adler, M. W., Rogers, T. J.and Eisenstein, T. K.: Cytokine re-versal of morphine-induced suppres-sion of the antibody response, 591

Butelman, E. R., France, C. P. and Woods,J. H.: Apparent pA2 analysis on therespiratory depressant effects of al-fentanil, etonitazene, ethylketocycla-zocin (EKC) and Mr2033 in rhesusmonkeys, 145

Butelman, E. R. and Woods, J. H.: Effectsof clonidine, dexmedetomidine and

xylazine on thermal antinociceptionin rhesus monkeys, 762

Butterworth, L. F., see Burns, L. A., 695tert-Butylhydroperoxide, -induced inhibi-

tion, lipid peroxidation, endothelialcell calcium signaling (calves), 1063

Buxton, I. L. 0., see Bradley, M. E., 1033Byssinosis, exposure to cotton dust, altera-

tion in modulatory role, respiratory

epithelium (guinea pigs), 683

Caffeine, cholinergic agonist- and K�-in-duced cytosolic-free Ca’’ signals, se-cretion, adrenal chromaffin cells(pigs),770

Calciumcoexistence of histamine H1 and H2 recep-

tors, signal transduction pathways,intestinal muscle cells (guinea pigs),

598dynamics, alterations by U46619, car-

diomyocytes (rats), 336hormone- and growth factor-based bone

resorption, suramin as inhibitor(mice), 579

K�-induced cytosolic-free signals, effects

of caffeine, adrenal chromaffin cells(pigs),770

signaling by endothelial cells, tert-butyl-hydroperoxide-induced inhibition,lipid peroxidation (calves), 1063

Calcium channel blockersenergy level and stimulated insulin secre-

tion, islets of Langerhans (rats), 35nimodipine, zidovudine kinetics (mon-

keys), 315

Calcium channels

block of two types, chlordiazepoxide,neuroblastoma cells (mice), 22

cocaine sensitization of coronary arterycontractions, mechanism, drug-in-duced spasm (cattle), 1132

inhibition of Na�-Ca� exchanger, anoxiaand glucopenia-induced aspartate re-lease, hippocampal slices (rats), 515

Canez, M. S., see King, T. S., 29

Cannabinoidsenantiomeric pairs, discriminative stim-

ulus effects, receptor binding (rats,

pigeons), 561natural and synthetic, aminoalkylindole

binding, cerebellum (rats), 1352

Canton, H., see Millan, M. J., 1364Captopril, peptidase inhibitors, neurogenic

plasma extravasation, nasal mucosa(rats), 509

Carbachol, activation of phospholipase C incortical slices, differential effects ofalkylating agents, muscarinic recep-

tor subtypes (rats), 521

Carbamate, comparison of antidote protec-tion against soman, pyridostigmine,

HI-6 and acetylcholinesterase, 1085Carbonic anhydrase, inhibitory activity,

ocular pharmacology, organic sulfa-

mates (rabbits), 670

Carcinoma, VX-2, antitumor effects ofTNP-470, microspheres and oil so-lution (rabbits), 469

Cardiomyocytes, calcium dynamics, altera-tionsby U46619 (rats),336

Cardiotoxicity, flecainide, modulation of so-dium channel blocking actions, ex-

tracellular sodium, 1160Cardiovascular system, pharmacological

profile of FR139317, ETA receptorantagonist (pigs), 1040

Carlisi, V. J., see Wild, K. D., 831Carr, D. J. J., Gebhardt, B. M. and Paul, D.:

Alpha adrenergic and Mu-2 opioidreceptors are involved in morphine-

induced suppression of splenocytenatural killer activity, 1179

Castle, N. A. and Slawsky, M. T.: Charac-terization of 4-aminopyridine blockof the transient outward K� currentin adult rat ventricular myocytes,1450

Cataplexy, control of, alpha-i receptor sub-type, narcolepsy (dogs), 1079

Catatonia, muscle rigidity, alfentanil-in-

duced antinociception, fl-funaltrex-amine and naloxonazine (rats), 739

Catechol compounds, pharmacological in-duction, physiologically active nervegrowth factor (rats), 321

Caudate nucleus, alpha-2 adrenoceptor sub-types (humans), 967

Caughey, G. H., Raymond, W. W., Bacci,E., Lombardy, R. J. and Tidwell, R.R.: Bis(5-amidino-2-benzimidazo-lyl)methane and related amidines arepotent, reversible inhibitors of mast

cell tryptases, 676Cederbaum, A. I., see Wu, D., 1468

Central nervous system

adrenal medullary modulation, bradyki-

nm-induced plasma extravasation,intrathecal nicotine (rats), 839

binding sites, cocaine-induced seizures,lethality, 1333

1496 Index Vol. 264

budipine effects, neurotransmitter release(rabbits), 889

Centurioni, M. G., see Alaoui-Jamali, M. A.,1299

Cerebellar granule cellsantisense oligodeoxynucleotide to mes-

senger RNAs, receptors with seventransmembrane spanning regions(rats), 423

muscarinic receptor-coupled phosphoino-sitide turnover, tetrahydroaminoac-ridine (rats), 463

Cerebellum

aminoalkylindole binding (rats), 1352

bicuculline-produced regional differences,

modulation of �S-TBPS binding,various agents (mice), 638

Cerebrospinal fluid, brain extracellularfluid, distributional transport kinet-ics, zidovudine (rabbits), 899

CGS 19755, excitatory amino acid agonists,dipsogenic effects (pigeons), 918

Chaki, K., see Ueki, S., 152Chen, H., Hamel, F. G., Siford, G. and Duck-

worth, W. C.: Alteration of rat he-patic insulin metabolism by glyburideand glipizide, 1293

Chen, J. B., Pillar, J. S., Shirley, J. T.,Showell, H. J., Watson, J. W. andCohan, V. L.: Antigen-mediated pul-monary eosinophilia in immunoglob-ulin G1-sensitized guinea pigs: Eosin-ophil peroxidase as a simple specificmarker for detecting eosinophils inbronchoalveolar lavage fluid, 922

Chen, L., see Yasumori, T., 89Chen, S. G., see Murakami, K., 757Chiamvimonvat, N., see Wang L., 1056Chiba, K., see Echizen, H., 1425Chiba, S., see Nakane, T., 1253Chinn, K.: Two delayed rectifiers in guinea

pig ventricular myocytes distin-guished by tail current kinetics, 553

Chiodo, L. A., see Pitts, D. K., 616Chlordiazepoxide, block of two types of cal-

cium channels, neuroblastoma cells

(mice), 22Chloride

electrolyte transport, inflammatory me-diators, distal colon epithelium(pigs), 61

neurally mediated action of leukotrienes,ion transport, distal colon (guineapigs), 384

Chloride channelscontractile effects of nucleotides, trachea

(guinea pigs), 210

relaxant effects of nucleotides, trachea(guinea pigs), 217

m-Chlorophenylbiguanide, 1-phenylbiguan-

ide and, behavioral effects (rats),1440

6-Chloropurine, detection and mechanismsof formation, S-(6-puri-nyl)glutathione, 6-mercaptopurine

(rats), 41

Cho, A. K., Hiramatsu, M., Schmitz, D. A.,Vargas, H. M. and Landaw, E. M.: Abehavioral and pharmacokineticstudy of the actions of phenylcycloh-exyldiethylamine and its active me-tabolite, phenylcyclohexylethylam-me, 1401

Cholecystokinin, FK506 characterization

and effects, exocytotic function, pan-creatic acini (rats), 873

Cholecystokinin-B, diphenylpyrazolidone,antagonists, midbrain dopamine neu-rons (rats), 480

Choline, presynaptic cholinergic actions,DuP 996 (rats), 910

Choroid plexus, chronic clozapine treat-

ment, decreased 5-HT1� receptordensity (rats), 1262

Chotinaruemol, S., see Miller, M. J. S., 11Chowdhury, P., see Doi, R., 873Christen, M. 0., see Ernsberger, P., 172Chuang, D.-M., see Sunaga, K., 463Cicero, T. J., Nock, B. and O’Connor, L.:

Naloxone does not reverse the inhib-itory effect of morphine on luteiniz-ing hormone secretion in prepubes-cent male rats, 47

Cicero, T. J., see Nock, B., 349Cimetidine, histamine release and contrac-

tion, influence ofepithelium, tracheal

strips (guinea pigs), 717Cisapride

gastroprokinetic activity of nizatidine(dogs, rats), 152

5-hydroxytryptamine and, motility in an-trum (dogs), 79

Clark, D. A., see Miller, M. J. S., 11Clarke, D. and Garg, L. C.: Alpha-2 adre-

nergic receptors in inner medullarycollecting duct cells of the rabbit kid-ney, 879

Clarke, D. E., see Waikar, M. V., 654Clenbuterol, aminohydroxybutane bisphos-

phonate and, prevention of bonechanges, retardation of muscle atro-

phy (rats), 1071Clineschmidt, B. V., see Pettibone, D. J.,

308

Clonidine

dexmedetomidine and ST-91, chronicspinal infusion, alpha-2 adrenoceptorsubtypes, 327

dexmedetomidine and xylazine, thermalantinociception (monkeys), 762

moxonidine, selective ligand, 11-imidazo-line sites (cattle), 172

Clozapine, decreased 5-HT1� receptor den-sity, comparison with haloperidol,choroid plexus (rats), 1262

Cocainechronic disruption of estrous cyclicity,

dose-dependent effects (rats), 29-induced seizures and lethality, central

nervous system binding sites, 1333self-administration, intermittent bupren-

orphine administration (monkeys),

530sensitization of coronary artery contrac-

tions, mechanism, drug-inducedspasm (cattle), 1132

tolerance and cross-tolerance (rats), 183Coffman, T. M., see Spurney, R. F., 584Cohan, V. L., see Chen, J. B., 922Cohen, M. L., see Cushing, D. J., 193Cohen, M. L., see Watts, S. W., 271

Colitis, experimental, epidermal growth fac-tor (rats), 984

Collins, A. C., see Marks, M. J., 542

Colombo, G., see Grant, K. A., 1241Colon

distal, neurally mediated action of leuko-trienes, ion transport (guinea pigs),384

distal epithelium, electrolyte transport,inflammatory mediators (pigs), 61

motility, cyclic nucleotide phosphodies-terase isozymes (dogs), 801

Colpaert, F. C., see Koek, W., 746Conklin, R., see Buckner, C. K., 717Connell, T. A., see Zhou, L.-W., 824

Cook, M. J., see Pettibone, D. J., 308Cortex, bicuculline-produced regional dif-

ferences, modulation of �S-TBPSbinding, various agents (mice), 638

Cosentino, M., see de Ponti, F., 789Cotton dust, alteration in modulatory role,

respiratory epithelium (guinea pigs),683

Couch, S. J., see DeGraff, G. L., 6Crema, A., see de Ponti, F., 789Crosland, R. D.: Effect of arachidonic acid

on twitch tension of the rat phrenicnerve-diaphragm, 1311

Cross, H. S., see Farsoudi, K. H., 579Crouch, J., see Badger, T. M., 438, 938Crouch, J., see Ronis, M. J. J., 944Cusack, B., see Di Paola, E. D., 1Cushing, D. J. and Cohen, M. L.: Serotonin-

induced contraction in porcine coro-nary artery: Use of ergolines to sup-port vascular 5-hydroxytryptamine2-

receptor heterogeneity, 193Cyclic adenosine monophosphate phospho-

diesterase, antidepressant-like ef-fects of rolipram, behavior, differen-tial reinforcement of low responserate (rats), 1168

Cyclic AMPaccumulation, bicarbonate-induced sen-

sitization, astrocytoma cells (hu-mans), 1211

coexistence of histamine H1 and H2 recep-tors, signal transduction pathways,intestinal muscle cells (guinea pigs),598

coupling of beta-i and beta-2 adrenocep-tors, connecting tubules, nephron(rabbits),105

decreased sensitivity, generation of mem-ory splenic CTL, aged mice, i381

extracellular, vasodilation, coronary ar-tery (dogs), 1253

inner medullary collecting duct cells, a!-pha-2 adrenergic receptors (rabbits),879

Cyclic GMP, autonomic nervous system, ni-tric oxide synthase, ileum (dogs), 234

Cyclo-oxygenase, lack of involvement, aden-osine-stimulated contraction, non-pregnant myometrium (guinea pigs),1033

Cytochrome P450chronic intragastric ethanol infusion, ep-

isodic ethanol excretion (rats), 93815 forms, regio- and stereoselective pro-

pranolol metabolism, liver (rats), 226

hepatic isozymes, chronic ethanol, growthhormone secretion (rats), 438

lack of involvement, metabolic activationof glyceryl trinitrate, aorta (rabbits),

1432repression of drug-metabolizing enzymes,

interleukin i�3, arthritis (rats), 1012stereoselective metabolism of mepheny-

tom, species differences (rats, rab-bits, dogs, monkeys, humans), 89

Cytochrome P450 2E1

1993 Index 1497

induction, alcohol exposure, two-stepmechanism (rats), 944

induction by pyrazole and 4-methylpyra-zole, liver, neonates (rats), 1468

Cytochrome P450 monooxygenase, distinctsignal transduction pathways, angio-tensin II, gastric smooth muscle(guinea pigs), 958

Cytokines, reversal of morphine-inducedsuppression, antibody response(mice), 591

Cytotoxic T-lymphocytes, memory splenic,decreased sensitivity to cAMP, agedmice, 1381

Czachura, J. F., see Rasmussen, K., 480

Dallman, M. F., see Miao, F. J.-P., 839Daly, D. A., see Youngren, K. D., 289

D’Ambra, T. E., see Kuster, J. E., 1352DAMGO, selective opioid agonists, modu-

lation of afferent transmission, nu-cleus tractus solitarius (rats), 795

Damon, T. H., see Ernsberger, P., 172D’Angelo, L., see de Ponti, F., 789Daniel, E. E., see Kostka, P., 234Daniel, E. E., see Shimamoto, Y., 201DAU 6285, pharmacological analyses at 5-

HI’4 receptor, tunica muscularis mu-cosae, ileum (rats, guinea pigs), 654

D’Costa, A., see Breese, C. R., 448Deadwyler, S. A., see Heyser, C. J., 294DeBernardis, J. F., see Firestone, J. A., 1206Defibrotide, stimulation of endogenous

prostacyclin, protection from is-

chemic injury, myocardium (pigs),397

DeGraff, G. L., Pals, D. T., Couch, S. J. andLawson, J. A.: Hormonal and cardi-ovascular effects of losartan (Du-P753), an angiotensin receptor an-tagonist, in nonhuman primates, 6

Dement, W. C., see Nishino, S., 1079O-Demethyl-encainide, interaction of so-

dium and potassium channel block-ers, papillary muscle (guinea pigs),1056

de Ponti, F., Einaudi, A., Cosentino, M.,

D’Angelo, L., Lecchini, S., Frigo, G.M. and Crema, A.: Differential effectsof antimuscarinic agents on intes-tinal motility in the conscious dog,789

De Ridder, W. J. E. and Schuurkes, J. A. J.:Cisapride and 5-hydroxytryptamineenhance motility in the canine an-trum via separate pathways, not in-volving 5-hydroxytryptamine recep-tors, 79

Des-Ar�-bradykinin, Bi and B2 kinin re-ceptors, superior mesenteric arterysmooth muscle cells (rabbits), 930

Desipramine, impairment oflatent learning,dopaminergic agonists (mice), 122

De Souza, E. B., see Katz, J. L., 183DeSouza, E. B., see Levant, B., 991Dexmedetomidine

clonidine and xylazine, thermal antinoci-ception (monkeys), 762

ST-91 and clonidine, chronic spinal in-fusion, a4,ha-2 adrenoceptor sub-types, 327

Diabetes mellitus, pharmacokinetics, 70-kil-odalton fluorescein-dextran (rats),662

Diaphragm, phrenic nerve, effect of arachi-donic acid, twitch tension (rats), 1311

Diazepam

-like independence, lack of induction,long-term treatment with abecarnil

(mice), 1395modulation of �S-TBPS binding, bicu-

culline-produced regional differ-ences, cerebellum and cortex (mice),

638Diet

chronic alcohol exposure, two-step mech-anism, cytochrome P450 CYP 2E1induction (rats), 944

chronic intragastric ethanol infusion, ep-isodic ethanol excretion (rats), 938

Dihydropyridine, renal nerve stimulation-induced antinatriuresis, suppressionby TMB-8 (dogs), 117

1,25-Dihydroxyvitamin D3, calcemic hor-mone- and growth factor-based boneresorption, suramin as inhibitor(mice), 579

Diltiazem, energy level and stimulated in-

sulin secretion, islets of Langerhans(rats), 35

meso-2,3-Dimercaptosuccinic acid, mixeddisulfide metabolite, reversal, galliumarsenide-induced suppression of an-tibody response (mice), 695

Di Paola, E. D., Cusack, B., Yamada, M.

and Richelson, E.: Desensitizationand down-regulation of neurotensinreceptors in murine neuroblastomaclone N1E-115 by [D-Lys8] neuroten-sin(8-13), 1

Diphenylpyrazolidinone, cholecystokinin-Band -A antagonists, electrophysiolog-ical effects, midbrain dopamine neu-rons (rats), 480

Dipropyl-5-carboxamidotryptamine, tra-cheal contractile serotonergic recep-tor, 5-HT2 receptor (guinea pigs), 271

Di Renzo, G., see Amoroso, S., 515Discriminative stimulus

ethanol effects, training dose, substitu-tion of NMDA antagonists (rats),1241

fentanyl from saline, phencyclidine-typedrugs (rats), 746

pharmacological specificity, 2-amino-4,5-

(1,2-cyclohexyl)-7-phosphonohep-tanoic acid (rats), 845

receptor binding of enantiomeric pairs(rats, pigeons), 561

triazolam, selectivity and sensitivity,novel-response procedure (humans),

360Disopyramide, mono-N-dealkylation me-

tabolism, potent inhibitory effect,erythromycin and other macrolideantibiotics (humans), 1425

Dithiothreitol, neuronal nicotinic acetyl-choline receptors, redox effects, ner-eistoxin (chicks), 689

Diuresis, furosemide, renal dopamine syn-thesis (rats), 1377

Diuretics, IC! 206,970, renal site of action,micropuncture study (rats), 604

DNA, complementary, cloning and expres-sion, uridine diphosphate-glucurono-syltransferase glucuronidating car-boxylic acid-containing drugs (hu-mans), 475

Doan, T. N., see Elliott, S. J., 1063Doctor, B. P., see Maxwell, D. M., 1085Doi, R., Inoue, K., Chowdhury, P. and Ray-

ford, P. L.: Biochemical characteriza-tion of the effects of FK506 on signaltransduction in exocytotic functionof rat pancreatic acini, 873

Domino, E. F. and Sheng, J.: N-methyl-D-asparate receptor antagonist and do-pamine D1 and D2 agonist interac-tions in 1-methyl-4-phenyl-i,2,5,6-

tetrahydropyridine-induced hemi-parkinsonian monkeys, 221

Dopamine

acetylcholine release and, quinpirole,

comparisons with B-HT 920 andSND 919, 1344

agonistsimpairment of latent learning (mice),

122

role of forebrain, repeated ampheta-mine administration (rats), 616

agonist YM435, renal microvascular ac-tions(rats), 1154

antidopaminergic and neuroleptic-like ac-tivities, -y-hydroxybutyrate ligands,1406

budipine effects, neurotransmitter re-lease, central nervous system tissue(rabbits), 889

cocaine tolerance and cross-tolerance(rats), 183

D2 agonists, ipsilateral rotations, AF64Alesions of striatum (mice), 824

D1 and D2 agonist interactions, NMDAreceptor antagonist, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineinduction (monkeys), 221

enhanced release, autoreceptor subsensi-tivity, amphetamine sensitization(rats),249

midbrain neurons, electrophysiologicaleffects, diphenylpyrazolidinone cho-lecystokinin-B and -A antagonists(rats), 480

outflow in nucleus accumbens, distinctactions, endogenous excitatoryamino acids (rats), 289

renal synthesis, diuretic effect of furose-mide (rats), 1377

synthesis in kidney, role of sodium (rats),406

Doran, 0., see Buckner, C. K., 717Dorsal raphe nucleus, methoxy-chroman de-

rivatives, agonist properties, central5-HT1A receptors (rats), 863

Dosaka-Akita, K., Tortella, F. C., Holaday,J. W. and Long, J. B.: The kappaopioid agonist U-50,488H antago-nizesrespiratoryeffectsof mu opioid

receptor agonists in conscious rats,631

Douse, T. P., see Homma, S., 105Doxorubicin, reversal of resistance by Rol 1-

2933 (rats), 1299Drieze, J. M., see Mello, N. K., 530Duan, D., Fermini, B. and Nattel, S.: Potas-

sium channel blocking properties ofpropafenone in rabbit atrial myo-cytes, 1113

Duckles, S. P., see Li, Z., 1305Duckworth, W. C., see Chen, H., 1293Duff, H. J., see Wang L., 1056DuP 753, EXP 3174 and, inhibitory effects

on responses to angiotensin II, hind-

quarters vascular bed (cats), 1104DuP 996, presynaptic cholinergic actions

(rats), 910

1498 Index Vol. 264

E-3330, protective effect, galactosamine-in-duced hepatitis (rats), 496

E-403i, two delayed rectifiers, ventricularmyocytes, tail current kinetics(guinea pigs), 553

Eager, S., see Jia, H., 1275Echizen, H., Kawasaki, H., Chiba, K., Tani,

M. and Ishizaki, T.: A potent inhibi-tory effect oferythromycin and othermacrolide antibiotics on the mono-N-dealkylation metabolism of diso-pyramide with human liver micro-somes, 1425

Ehrhardt, J.-D., see Hechler, V., 1406Eicosanoid, glomerular thromboxane recep-

tors, lupus nephritis (mice), 584Einaudi, A., see de Ponti, F., 789Eisenstein, T. K., see Bussiere, J. L., 591Electrolytes, transport across distal colon

epithelium, inflammatory mediators(pigs), 61

Elfarra, A. A., see Hwang, I.-Y., 41Elliott, S. J., Doan, T. N. and Schilling, W.

P.: Role of lipid peroxidation in tert-butylhydroperoxide-induced inhibi-tion of endothelial cell calcium sig-naling, 1063

El-Mas, M. M. and Abdel-Rahman, A. A.:Direct evidence for selective involve-ment of aortic baroreceptors inethanol-induced impairment of bar-oreflex control of heart rate, 1198

Eltoprazine, induction of hypothermia, 5-HTIA receptor-mediated activity

(rats), 1364Emmett-Oglesby, M. W., see Prather, P. L.,

622Endo-6-methoxy-8-methyl-8-azabicy-

clo[3.2.i]oct-3-yl-2,3-dihydro-2 -oxo-1H-benimidazole-1-carboxylate hy-drochloride, see DAU 6285

�9-Endorphin

naloxone-resistant receptors, protein ki-nase C activation, U937 cells, 276

properties ofepsilon opioid receptor, brain(rats, guinea pigs, cows, pigs, chick-ens), 349

Endothelial cells, calcium signaling, lipidperoxidation, tert-butylhydroperox-ide-induced inhibition (calves), 1063

EndothelinETA receptor antagonist, pharmacological

profile, FR139317 (pigs), 1040renal microvascular actions of YM435

(rats), 1154Endothelin- 1, precontraction, contraction

with rauwolscine, mesenteric artery(dogs), 201

Endothelium, relaxation, 5-HT receptors,jugular vein (rats), 709

Enero, M. A., see Nowicki, S., 1377Eosinophilia, pulmonary, antigens, IgGi

sensitization (guinea pigs), 922

Epidermal growth factorbone resorption, suramin as inhibitor

(mice), 579distinct signal transduction pathways, an-

giotensin II, gastric smooth muscle(guinea pigs), 958

experimental colitis (rats), 984Epithelium

distal colon, electrolyte transport, inflam-matory mediators (pigs), 61

histamine release and contraction, phar-

macologic modulation, tracheal strips(guinea pigs), 717

relaxant effects of nucleotides, trachea(guinea pigs), 217

respiratoryalteration in modulatory role, exposure

to cotton dust (guinea pigs), 683

contractile effects, nucleotides (guineapigs), 210

Epstein, M., see Takenaka, T., 1154Ereci#{241}ska,M., see Ohta, M., 35Ergolines, serotonin-induced contraction of

coronary artery, vascular 5-HT2-re-ceptor heterogeneity (pigs), 193

Ernsberger, P., Damon, T. H., Graff, L. M.,Schafer, S. G. and Christen, M. 0.:Moxonidine, a centrally acting anti-hypertensive agent, is a selective ii-gand for 11-imidazoline sites, 172

Errett, C. J., see Thomas G. R., 67Erythromycin, other macrolide antibiotics

and, potent inhibitory effect, mono-N-dealkylation metabolism of diso-pyramide (humans), 1425

Escaf, S., see Ricci, A., 431Esophagus, tunica muscularis mucosae and

ileum, pharmacological analyses,DAU 6285 (rats, guinea pigs), 654

Estradiol benzoate, hormonal regulation of

acetohexamide reductase, postnataldevelopment, liver and kidney (rats),166

Estrous, cyclicity, chronic cocaine disrup-tion, dose-dependent effects (rats),29

Ethanolr-aminobutyric acid-induced depressions,

cerebellar Purkinje neurons (rats),951

chronic, growth hormone secretion, he-patic cytochrome P450 isozymes(rats), 438

discriminative stimulus effects, training

dose, substitution of NMDA antago-nists (rats), 1241

episodic excretion, chronic intragastricethanol infusion (rats), 938

-induced desensitization of adenylate cy-clam, adenosine receptor, GTP-bind-ing proteins, 977

-induced impairment of baroreflex con-trol, aortic baroreceptors, heart rate(rats), 1198

in utero exposure, long-term suppression,insulin-like growth factor-i (rats),448

i,1,1-trichloroethane-produced physicaldependence, effects of drugs and va-pors, withdrawal (mice), 726

Ethylketocyclazocineproperties ofepsilon opioid receptor, brain

(rats, guinea pigs, cows, pigs, chick-ens), 349

respiratory depressant effects, apparentpA2 analysis (monkeys), 145

Etonitazene, respiratory depressant effects,apparent pA2 analysis (monkeys),145

Etorphine, -induced sensitization of adeny-lyl cyclase, buprenorphine preven-tion and reversal, neuroblastomacells, 368

Evans, B. E., see Pettibone, D. J., 308Evans, E. B. and Balster, R. L.: Inhaled 1,

1,i-trichlorethane-produced physical

dependence in mice: Effects of drugsand vapors on withdrawal, 726

Ewing, J. F., see Maines, M. D., 457

EXP 3174, DuP 753 and, inhibitory effectson responses to angiotensin II, hind-quarters vascular bed (cats), 1104

Eye, ocular pharmacology of organic sulfa-mates, carbonic anhydrase inhibitoryactivity (rabbits), 670

Faili, A., see Mounier, C., 1460Fain, J. N., see Sall#{233}s,J., 521Farnham, D. A., see Marks, M. J., 542Farsoudi, K. H., Pietschmann, P., Cross, H.

S. and Peterlik, M.: Suramin is a

potent inhibitor of calcemic hor-mone- and growth factor-inducedbone resorption in vitro, 579

Fattaccini, C.-M., see Kidd, E. J., 863

Fatty acidseffect of arachidonic acid on twitch ten-

sion, phrenic nerve-diaphragm (rats),

1311

imbalance between glycolysis and glucoseoxidation, aerobic reperfusion, is-chemic heart (rats), 135

inhibition of brain protein kinase C sub-types, lead (rats), 757

Fedan, J. S., Belt, J. J., Yuan, L.-X. andFrazer, D. 0.: Contractile effects ofnucleotides in guinea pig isolated,perfused trachea: Involvement of res-piratory epithelium, prostanoids andNa� and C� channels, 210

Fedan, J. S., Belt, J. J., Yuan, L.-X. andFrazer, D. G.: Relaxant effects of nu-cleotides in guinea pig isolated, per-fused trachea: Lack of involvementof prostanoids, Cr channels andadenosine, 217

Fedan, J. S., see Smith, J. A., 683

Felbamate, anticonvulsant and neuropro-tectant action, strychnine-insensi-tive glycine receptors, 1248

Fener, P., see Ferrari, L., 1012Feng, G., see Murakami, K., 757

Fentanyl, discrimination from saline, phen-cyclidine-type drugs (rats), 746

Ferkany, J. W., Hamilton, G. S., Patch, H.J., Huang, Z., Borosky, S. A., Bednar,D. L., Jones, B. E., Zubrowski, H.,Willetts, J. and Karbon, E. W.: Phar-macological profile of NPC 17742[2R, 4R, 5S-(2-Amino-4,5-(1,2-Cy-clohexyl)-7-PhosphoneptanoicAcid)J, a potent, selective and com-petitive N-methyl-D-aspartate recep-ton antagonist, 256

Fermini, B., see Duan, D., 1113Fermini, B., see Ranger, S., 1160Fernandes, H., see Soares-[da]-Silva, P., 406Ferrari, L., Jouzeau, J. -Y., Gillet, P., Her-

ber, H., Fener, P., Batt, A. -M. andNetter, P.: Interleukin-lfl differen-tially represses drug-metabolizingenzymes in arthritic female rats, 1012

Fetal alcohol syndrome, in utero ethanolexposure, long-term suppression, in-sulin-like growth factor-i (rats), 448

Fibiger, H. C., see Robertson, G. S., 1344Fibrogen, optimized thrombolysis, tissue-

type plasminogen activator, embolicstroke (rabbits), 67

Filtz, T. M., see Boundy, V. A., 1002Firestone, J. A., Gerhardt, G. A., De-

Bernardis, J. F., McKelvy, J. F. and

1993 Index 1499

Browning, M. D.: Actions of A-75200,a novel catecholamine uptake inhib-itor, on norepinephrine uptake andrelease from bovine adrenal chromaf-fin cells, 1206

Fishleder, R. I., see Buckner, C. K., 717FK506, biochemical characterization, signal

transduction, exocytotic function ofpancreatic acini (rats), 873

Flecainide, modulation of sodium channelblocking actions, extracellular so-dium, 1160

Flumazenil, benzodiazepine withdrawal,conflicting evidence regarding effi-cacy, ondansetron (rats), 622

Flunarizine, energy level and stimulated in-sulin secretion, islets of Langerhans(rats), 35

Fluorescein-dextran, 70-kilodalton, phar-macokinetics, diabetes mellitus(rats), 662

Flynn, D. L., see Gullikson, G. W., 240Ford, A. P. D. W., see Waikar, M. V., 654Forebrain, responsiveness of nigrostriatal

dopamine neurons, dopamine ago-nists, repeated amphetamine admin-istration (rats), 616

Forsberg, E. J., see Xu, Y., 770Forskolin

inner medullary collecting duct cells, a!-pha-2 adrenergic receptors (rabbits),879

isobutylmethylxanthine and, delta opioidreceptor activity, NG1O8-i5 cells,1474

Forster, J., see Takenaka, T., 1154FR139317, pharmacological profile (pigs),

1040France, C. P., see Butelman, E. H., 145Franklin, P. H., see Zhang, G., 1415Frazer, D. G., see Fedan, J. S., 210, 217Fraser, D. G., see Smith, J. A., 683Freeman, A. S., see Pitts, D. K., 616Freidinger, R. M., see Pettibone, D. J., 308Frey, K. A., see Zubieta, J. K., 415

Frigo, G. M., see de Ponti, F., 789Fruhstorfer, B., see Nishino, S., 1079Fujita, S., Umeda, S., Funae, Y., Imaoka, S.,

Hiroko, A., Ishida, R., Adachi, T.,Masuda, M., Kazusaka, A. and Su-zuki, T.: Regio-and stereoselectivepropranolol metabolism by 15 formsof purified cytochromes P-450 fromrat liver, 226

Funae, Y., see Fujita, S., 226fl-Funaltrexamine, naloxonazine and, alfen-

tanil-induced antinociception, mus-cle rigidity (rats), 739

Furosemide, diuretic effect, renal dopaminesynthesis (rats), 1377

Furukawa, K., see Oka, M., 158Furukawa, S., see Kaechi, K., 321Furukawa, T., see Jia, H., 1275Furukawa, Y., see Kaechi, K., 321

Galactosamine, -induced hepatitis, protec-tive effect of E3330 (rats), 496

Galligan J. J.: Differential inhibition of cho-linergic and noncholinergic neuro-genic contractions by mu opioid anda�pha-2 adrenergic agonists in guineapig lleum, 375

Gallitano, A. L., see Boundy, V. A., 1002Gallium arsenide, -induced suppression of

antibody response, reversal, mixed

disulfide metabolite of meso-2,3-di-mercaptosuccinic acid (mice), 695

Gallo, J. M., Swagler, A. H., Mehta, M. andQian, M.: Pharmacokinetic evalua-

tion of drug interactions with anti-

human immunodeficiency virusdrugs. VI. Effect on the calciumchannel blocker nimodipine on zido-vudine kinetics in monkeys, 315

Garcia-Sevilla, J. A., see Miralles, A., 1187Garg, L. C., see Clarke, D., 879Gaskill, S., see King, T. S., 29

Gastric emptying, solid and liquid meals,gastrointestinal motility, SC-49518(dogs), 240

Gastrointestinal tractgastroprokinetic activity of nizatidine

(dogs, rats), 152ileum, autonomic nervous system, nitric

oxide synthase (dogs), 234motility in antrum, cisapride and 5-hy-

droxytryptamine (dogs), 79GBR 12909

cocaine tolerance and cross-tolerance(rats), 183

impairment of latent learning (mice), 122

Gebhardt, B. M., see Carr, D. J. J., 1179Gellai, M., see Nambi, P., 345

Gender differences, survival during hypoxia,cholinergic and anticholinergic drugeffects (mice), 1146

Genistein, distinct signal transduction path-ways, angiotensin II, gastric smoothmuscle (guinea pigs), 958

George, F. H., see Ritz, M. C., 1333

Gerber, N., see Apseloff G., 1071Gerhardt, G. A., see Firestone, J. A., 1206Gillet, P., see Ferrari, L., 1012

Giordano, A. L., see Nock, B., 349Girten, B., see Apseloff G., 1071Giuliani, S., see Lecci A., 1327Glaucoma, carbonic anhydrase inhibitory

activity, ocular pharmacology, or-ganic sulfamates (rabbits), 670

Glaum, S. H., see Rhim, H., 795

Glibenclamide, modulation of low affinitybinding sites, nucleotides, brain(rats), 701

Glipizide, glyburide and, alteration, hepaticinsulin metabolism (rats), 1293

Glomerular filtrate rate, postischemic renalvasoconstriction, interaction, throm-boxane A2 and angiotensin II (dogs),1285

Glucopenia, -induced aspartate release, in-hibition of Na�-Ca� exchanger, hip-pocampal slices (rats), 515

Glucoseenergy level and stimulated insulin secre-

tion, Ca� channel blockers, islets of

Langerhans (rats), 35oxidation and glycolysis, fatty acids, aero-

bic reperfusion of ischemic hearts(rats),135

Glutamate, distinct actions of endogenousexcitatory amino acids, outflow of do-pamine, nucleus accumbens (rats),289

-y-Glutamyltransferase, repression of drug-metabolizing enzymes, interleukin1/I, arthritis (rats), 1012

-y-Glutamyltranspeptidase, tubular secre-tion and reabsorption, mercury com-pounds, kidney (mice), 776

Glutathione, tubular secretion and reab-

sorption, mercury compounds, kid-ney (mice), 776

Glutathione S-transferase, detection andmechanisms of formation, S-(6-puri-nyl)glutathione and 6-mercaptopu-nine, 6-chloropurine (rats), 41

Glyburide, glipizide and, alteration, hepaticinsulin metabolism (rats), 1293

Glyceryl trinitrate, metabolic activation,lack of involvement of cytochnome P-450, aorta (rabbits), 1432

Glycine, strychnine-insensitive receptors,anticonvulsant and neuroprotectantaction, felbamate, 1248

Glycolysis, glucose oxidation and, fattyacids, aerobic reperfusion of ischemichearts (rats), 135

Gobaille, S., see Hechler, V., 1406

Gobert, A., see Millan, M. J., 1364Goldenberg, H., see Webb, M. L., 1387Goldman, D. W., see Proud, D., 1124

Goldstein, B., see Gullikson, G. W., 240Gonadotropins, chronic cocaine disruption,

estrous cyclicity, dose-dependent ef-

fects (rats), 29Gonzales, R. A., Roper, L. C. and West-

brook, S. L: Cholinergic modulationof N-methyl-D-aspartate-evoked[3H]norepinephrine release from ratcortical slices, 282

Goso, C., see Patacchini, H., 17

Gozlan, H., see Kidd, E. J., 863GR 82,334, initiation of micturition reflex,

peripheral role, tachykinins (rats),1327

Grady, S. H., see Marks, M. J., 542Graff, L. M., see Ernsberger, P., 172

Grant, K. A. and Colombo, G.: Discrimina-tive stimulus effects ofethanol: effectof training dose on the substitutionof N-methyl-D-aspartate antago-nists, 1241

Gravity, tail-suspended rats, prevention ofbone changes, aminohydroxybutanebisphosphonate and clenbuterol,1071

Graziano, F. M., see Buckner, C. K., 717Grider, J. H., see Morini, G., 598Gniffiths, J. W., see Katz, J. L., 183Grigoriadis, D. E., see Levant, B., 991Growth hormone

secretion, chronic ethanol, hepatic cyto-chrome P450 isozymes (rats), 438

somatostatin receptor subtypes, anteriorpituitary cell line GH3 (rats), 110

GTP-binding proteins, ethanol-induced de-sensitization, adenylate cyclase, 977

Guanosine triphosphate, effects of ATP andrelated nucleotides, tone, mesentericresistance arteries (rats), 1234

Guanylate cyclase, -coupled receptors, al-tered neurotransmission, atrial natri-uretic factor (rabbits), 1227

Guardiola-Lemaitre, B., see Kidd, E. J., 863Guilleminault, C., see Nishino, S., 1079

Gullikson, G. W., Virina, M. A., Loeffler, R.F., Yang, D.-C., Goldstein, B., Wang,S.-X., Moummi, C., Flynn, D. L. andZabrowski, D. L.: SC-49518 enhancesgastric emptying of solid and liquidmeals and stimulates gastrointestinalmotility in dogs by a 5-hydroxytryptamine4 receptor mecha-nism, 240

Gummelt, D., see Tropea, M. M., 930

1500 Index Vol. 264

Hadv#{225}ry,P., see Roux, S. P., 501Haile, D., see Neely, C. F., 1315Haj-Dahmane, S., see Kidd, E. J., 863

Halaris, A. E., see Ordway, G. A., 967Haloperidol

chronic clozapine treatment, decreased 5-GT1� receptor density, choroid plexus(rats), 1262

pharmacological profile of AD-5423(mice, rats), 158

phencyclidine-type drugs, discriminationof fentanyl from saline (rats), 746

Haluska, G. J., see Pettibone, D. J., 308Hamel, F. G., see Chen, H., 1293Hamilton, G. S., see Ferkany, J. W., 256Hammerbeck, D. M. and Brown, D. R.:

Neurally mediated actions of leuko-trienes on ion transport in guinea pigdistal colon, 384

Hamon, M., see Kidd, E. J., 863Hampson, H. E., see Heyser, C. J., 294Hansson, K., see Lundin, S., 783Hanus, L., see J#{228}rbe,T. U. C., 561Harris, D. N., see Ogletree, M. L., 570Harris, D. N., see Webb, M. L., 1387Harrison, N. L., see Lovinger, D. M., 1097Hashimoto, Y., see Kaechi, K., 321Hatmi, M., see Mounier, C., 1460Hatzidimitriou, G., see Scanzello, C. H.,

1484

Hayashi, K., see Kaechi, K., 321Haycock, D. A., see Kuster, J. E., 1352Heart, ischemic, imbalance between glycol-

ysis and glucose oxidation, fatty acids(rats), 135

Heart rate, ethanol-induced impairment ofbaroreflex control, aortic barorecep-tors (rats), 1198

Heat shock proteins, induction of heme ox-ygenase-1 messenger RNA and pro-tein, ischemia/reperfusion, kidney(rats), 457

Hechler, V., Peter, P., Gobaille, S., Bour-guignon, J.-J., Schmitt, M., Ehr-hardt, J.-D., Mark, J. and Maitre, M.:-y-hydrooxybutyrate ligands possessantidopaminergic and neuroleptic-like activities, 1406

Hedberg, A., see Webb, M. L., 1387Hegde, S. S., see Waikar, M. V., 654Heinroth-Hoffmann, I., see Hoffmann, P.,

336Heme oxygenase-1, messenger RNA and

protein, induction by ischemia/reper-fusion, kidney (rats), 457

Hemiparkinsonism, i-methyl-4-phenyl-1,2,5,6-tetrahydropyridine induction,

NMDA receptor antagonist, dopa-mine D1 and D2 agonist interactions(monkeys), 221

Hemoproteins, lack of involvement of cyto-chrome P-450, metabolic activationof glyceryl trinitrate, aorta (rabbits),1432

Heparmn, coronary artery reperfusion andreocclusion, thrombolysis, tissue-type plasminogen activator (dogs),501

Hepatitis, galactosamine-induced, protec-tive effect of E3330 (rats), 496

Herber, H., see Ferrari, L., 1012Hers, A., see Bals-Kubik, H., 489Herzig, M. S., see Tropea, M. M., 930Heyser, C. J., Hampson, H. E. and Dead-

wyler, S. A.: Effects of delta-9-tetrah-

ydrocanninol on delayed match tosample performance in rats: Altera-tions in short-term memory associ-ated with changes in task specific

firing of hippocampal cells, 4, 29HI-6, pyridostigmine and acetylcholinester-

ase, comparison of antidote protec-tion, soman, 1085

Hietala, J., see Kuoppamki, M., 1262Higgins, G. A., Joharchi, N. and Sellers, E.

M.: Behavioral effects of the 5-hydroxytryptamine3 receptor ago-nists 1-phenylbiguanide and m-chlo-rophenylbiguanide in rats, 1440

Higgins, S. T., see Bickel, W. K., 360Higgins, S. T., see Rush, C. H., 1218Higuchi T., see Imamura, Y., 166Hiltunen, A. J., see J#{228}rbe,T. U. C., 561Hino, K., see Oka, M., 158Hippocampus

alpha-2 adrenoceptor subtypes (humans),967

delayed match to sample performance, #{244}-9-tetrahydrocannabinol (rats), 294

inhibition of Na�-Ca� exchanger, anoxia,glucopenia-induced aspartate release(rats), 515

muscarmic autoreceptor, pharmacologicalcharacterization (rats), 74

neurons, trichloroethanol-potentiatedsynaptic transmission, mediation byGABAA receptors, 1097

Hiroko, A., see Fujita, S., 226Hirota, K., see Nagakawa, J.-I., 496Hisa, H., see Ogasawara, A., 117Hishinuma, I., see Nagakawa, J.-I., 496Histamine

inflammatory mediators, electrolytetransport, distal colon epithelium(pigs), 61

norepinephrine release, paraventricularnucleus/anterior hypothalamus(rats), 734

release and contraction in tracheal strips,pharmacologic modulation, influenceon epithelium (guinea pigs), 717

Hoe 140, inhibition of B2 kinin receptormediation, bradykinin effects (guineapigs), 1124

Hoffman, A. and Levy, G.: Kinetics of drugaction in disease states. XLI. Effectof adrenalectomy on the hypnotic ac-tivity ofphenobarbital, the neurotox-icity of theophylline and pain sensi-tivity in rats, 859

Hoffman, B. B., see Thomas, J. M., 368Hoffmann, P., Heinroth-Hoffmann, I. and

Toraason, M.: Alterations by athromboxane A2 analog (U46619) of

calcium dynamics in isolated rat car-diomyocytes, 336

Hohlfeld, T., Strobach, H. and Schror, K.:Stimulation of endogenous prostacy-din protects the reperfused pig myo-cardium from ischemic injury, 397

Holaday, J. W., see Dosaka-Akita, K., 631Hollenberg, M. D., see Yang, S.-G., 958Holopainen, I. and Wojcik, W. J.: A specific

antisense oligodeoxynucleotide to

mRNAs encoding receptors withseven transmembrane spanning re-gions decreases muscarinic m2 and -y-aminobutyric acidB receptors in ratcerebellar granule cells, 423

Holzer, P., Schluet, W. and Maggi, C. A.:

Ascending enteric reflex contraction:Roles of acetylcholine and tachyki-

nins in relation to distension andpropagation of excitation, 391

Homma, S., Kusano, E., Takeda, S., Muray-ama, N., Asano, Y. and Douse, T. P.:Both beta-i and beta-2 adrenoceptorsare coupled to the cyclic AMP systemin connecting tubules of rabbit neph-ron, 105

Hooper, M. L., see Prather, P. L., 622Hori, Y., see Ueki, S., 152Howbert, J. J., see Rasmussen, K., 480Howell, R. E., Sickels, B. D. and Woeppel,

S. L.: Pulmonary antiallergic andbronchodilator effects of isozyme-se-lective phosphodiesterase inhibitorsin guinea pigs, 609

Hruby, V. J., see Wild, K. D., 831Huang, H.-Y., see Jackisch, H., 889Huang, J., see Badger, T. M., 438Huang, Z., see Ferkany, J. W., 256Hughes, J. H., see Bickel, W. K., 360Hughes, J. H., see Rush, C. H., 1218Human immunodeficiency virus, nimodi-

pine effect on zidovudine kinetics(monkeys), 315

Hwang, I.-Y. and Elfarra, A. A.: Detectionand mechanisms of formation of S-(6-Purinyl)glutathione and 6-mer-captopurine in rats given 6-chloro-purine, 41

Hydromorphone, pentazocine and, differ-ential naltrexone antagonism (hu-mans), 813

-y-Hydroxybutyrate, ligands, antidopami-nergic and neuroleptic-like activities,1406

5-Hydroxytryptamine, cisapride and, motil-ity in antrum (dogs), 79

Hypertensionacute and chronic mechanism, ketanserin

(rats), 129

renal site of action, ICI 206,970, micro-puncture study (rats), 604

Hypothalamus, anterior, histamine release,norepinephrine (rats), 734

Hypothermia, 5-HT1A receptor-mediatedactivity (rats), 1364

Hypoxia, survival during, cholinergic andanticholinergic drug effects, genderdifferences (mice), 1146

Ichihara, K., Nabeshima, T., Kameyama,T.: Dopaminergic agonists impair la-tent learning in mice: Possible mod-ulation by noradrenergic function,122

ICI 206,970, renal site of action, micropunc-ture study (rats), 604

Idazoxan, discrimination and pharmacolog-ical characterization, 12-imidazolinesites, brain (humans, rats), 1187

Igegami, H., see Kaechi, K., 321

Ileitis, chronic, amelioration, nitric oxidesynthase inhibition (rats), 11

Ileumautonomic nervous system, nitric oxide

synthase (dogs), 234cholinergic and noncholinergic neuro-

genic contractions, mu opioid and a!-

pha-2 adrenergic agonists (guineapigs), 375

neurokinin A derivatives, agonist and an-tagonist properties, C-terminal ami-

1993 Index 1501

dation (guinea pigs, rabbits, ham-sters, rats), 17

tunica muscularis mucosae and, pharma-cological analyses, DAU 6285 (rats,

guinea pigs), 654withdrawal responses, effects of NSAIDs,

brief exposure to morphine (guineapigs), 1028

Imamura, Y., Iwamoto, K., Yanachi, Y.,Higuchi, T. and Otagiri, M.: Postna-tal development, sex-related differ-ence and hormonal regulation of ace-

tohexamide reductase activities in ratliver and kidney, 166

Imaoka, S., see Fujita, S., 226Imidazoline, moxonidine, selective ligand

(cattle), 17212-Imidazoline, discrimination and pharma-

cological characterization, idazoxanand alpha-2 adrenoceptors,RX821002 in brain (humans, rats),1187

Immunoglobulin Gi, sensitization, antigen-mediated pulmonary eosinophilia(guinea pigs), 922

Immunosuppression, gallium arsenide-in-duced, reversal, mixed disulfide me-tabolite of meso-2,3-dimercaptosuc-cinic acid (mice), 695

Impicciatore, M., see Morini, G., 598Imura, N., see Tanaka-Kagawa, T., 776Ingelman-Sundberg, M., see Badger, T. M.,

438Ingelman-Sundberg, M., see Ronis, M. J. J.,

944Ingram, H. L., see Breese, C. H., 448Inositol phosphate, formation, Bi and B2

kinin receptors, superior mesentericartery smooth muscle cells (rabbits),930

Inoue, K., see Doi, H., 873Inoue, Y., see Kamei, S., 469Insulin

hepatic metabolism, glyburide and glipi-zide (rats), 1293

70-kilodalton fluorescein-dextran, phar-macokinetics, diabetes mellitus(rats), 662

secretion in islets of Langerhans, energylevel, effect of Ca’� channel blockers(rats), 35

Insulin-like growth factor-i, long-termsuppression, in utero ethanol expo-sure (rats), 448

Interleukin 1�3, repression of drug-metabo-lizing enzymes, arthritis (rats), 1012

Interleukins, morphine-induced suppres-sion, cytokine reversal, antibody re-sponse (mice), 591

Intestineamelioration ofchronic ileitis, nitric oxide

synthase inhibition (rats), iiascending enteric reflex contraction,

propagation of excitation, acetylcho-line and tachykinins (guinea pigs),391

motility, differential effects, antimuscar-inic agents (dogs), 789

muscle cells, histamine H1 and H2 recep-tors, signal transduction pathways(guinea pigs), 598

Inturrisi, C. E., see Tiseo, P. J., 1090Ion transport

jejunum, neuropeptide Y, peptide YY andsigma ligands (mice), 1268

neurally mediated actions of leukotrienes,distal colon (guinea pigs), 384

Ipsapirone, benzodiazepine withdrawal,conflicting evidence regarding effi-cacy, ondansetron (rats), 622

Irby, D., see Badger, T. M., 438, 938Irby, D., see Ronis, M. J. J., 944Ischemia

-induced acute renal failure, kidney en-dothelin receptors (rats), 345

induction of heme oxygenase-1 messengerRNA and protein, kidney (rats), 457

renal vasoconstriction, interaction,thromboxane A2 and angiotensin II(dogs), 1285

Ishida, H., see Fujita, S., 226Ishitani, H., see Sunaga, K., 463Ishizaki, T., see Echizen, H., 1425Isobutylmethylxanthine, forskolin and,

delta opioid receptor activity,NG1O8-i5 cells, 1474

Isoproterenol, r-aminobutyric acid-induceddepression, ethanol effects, cerebellarPurkinje neurons (rats), 951

Iwamoto, K., see Imamura, Y., 166

Jackisch, R., Huang, H. -Y., Reimann, W.and Limberger, N.: Effects of the an-tiparkinsonian drug budipine on neu-rotransmitter release in central nerv-ous system tissue in vitro, 889

Jaconetta, S. M., see Ordway, G. A., 967Jakubovic, A., see Robertson, G. S., 1344Jang, E., see Kostka, P., 234Jarbe, T. U. C., Hiltunen, A. J., Mathis, D.

A., Hanus, L., Breuer, A. and Mech-oulam, R.: Discriminative stimuluseffects and receptor binding of en-antiomeric pairs of cannabinoids inrats and pigeons; a comparison, 561

Javors, M. A., see King, T. S., 29Jejunum, ion transport, neuropeptide Y,

peptide YY and Sigma ligands (mice),1268

Jia, H., Furukawa, T., Singer, D. H., Sak-akibara, Y., Eager, S., Backer, C.,Arentzen, C. and Wasserstrom, J. A.:Characteristics of lidocaine block ofsodium channels in single humanatrial cells, 1275

Jiang, Q., Seyed-Mozaffari, A., Archer, S.and Bidlack, J. M.: Pharmacologicalstudy of i4fl-(thioglycolamido)-7,8-dihydro-N(cyclopropylmethyl)-nor-morph inone (N-CPM-TAMO), 1021

Jin, C., Miners, J. 0., Lillywhite, K. J. andMackenzie, P. I.: Complementary de-oxyribonucleic acid cloning andexpression of a human liver uridinediphosphate-glucuronsyltransferaseglucuronidating carboxylic acid-con-taming drugs, 475

Johnston, P. A. and Kau, S. T.: A micro-puncture study on the renal site ofaction of ICI 206,970, a unique eu-kalemic diuretic, 604

Jolas, T., see Kidd, E. J., 863Jonarchi, N., see Higgins, G. A., 1440Jones, B. E., see Ferkany, J. W., 256Jones, M. V., see Lovinger, D. M., 1097Jouzeau, J.-Y., see Ferrari, L., 1012Jugus, M., see Nambi, P., 345Junien, J. L., see Riviere, P. J. M., 1268Juul, B., Plesner, L. and Aalkjaer, C.: Ef-

fects of ATP and related nucleotides

on the tone of isolated rat mesentericresistance arteries, 1234

Kadowitz, P. J., see Osei, S. Y., 1104Kaechi, K., Furukawa, Y., Igegami, H., Nak-

amura, N., Omae, F., Hashimoto, Y.,Hayashi, K. and Furukawa, S.: Phar-macological induction of physiologi-cally active nerve growth factor in ratperipheral nervous system, 321

Kainate, excitatory amino acid agonists,dipsogenic effects (pigeons), 918

Kakkis, J. L., see Miller, M. J. S., iiKallen, H. G., see Boundy, V. A., 1002

Kalsner, S.: Cocaine sensitization of coro-nary artery contractions: Mechanismof drug-induced spasm, 1132

Kamei, S., Okada, H., Inoue, Y., Yoshioka,T., Ogawa, Y. and Toguchi, H.: An-titumor effects of angiogenesis inhib-itor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administra-tion of microspheres and oil solution,469

Kameyama, T., see Ichihara, K., 122

Kamien, J. B., see Bickel, W. K., 360Kamien, J. B., see Mello, N. K., 530Karasawa, T., see Oka, M., 158Karbon, E. W., see Ferkany, J. W., 256Katayama, K.-I., see Nagakawa, J.-I., 496Kato, H., see Yasumori, T., 89Katz, J. L., Griffiths, J. W., Sharpe, L. G.,

De Souza, E. B. and Witkin, J. M.:Cocaine tolerance and cross-toler-ance, 183

Katz, J. L., see Scanzello, C. H., 1484Kau, S. T., see Johnston, P. A., 604Kawasaki, H., see Echizen, H., 1425Kazusaka, A., see Fujita, S., 226Kelland, M. D., see Pitts, D. K., 616Ketanserin, acute and chronic hypertensive

mechanism (rats), 129a-Ketoisocaproate, energy level and stimu-

lated insulin secretion, Ca�� channelblockers, islets of Langerhans (rats),35

Khansa, M. H., see Wolf, M. E., 249Kidd, E. J., Haj-Dahmane, S., Jolas, T.,

Lanfumey, L., Fattaccini, C.-M.,Guardiola-Lemaitre, B., Gozlan, H.and Hamon, M.: New methoxy-chro-man derivatives, 4[N-(5-methoxy-chroman-3-yl)N-propylaminojbutyl-8-azaspiro-(4,5)- decane-7,9-dione[(±)-520244] and its enantiomers,

(+)-S 20499 and (-)-S 20500, withpotent agonist properties at central5-hydroxytryptamine1. receptors, 863

Kidneyautoradiographic localization, dopamine

D1 receptors (humans), 431connecting tubules of nephron, coupling

of beta-i and beta-2 adrenoceptors(rabbits), 105

dopamine synthesis, diuretic effect of fu-rosemide (rats), 1377

endothelin receptors, ischemia-inducedacute renal failure (rats), 345

heme oxygenase-i messenger RNA andprotein, induction by ischemia/reper-fusion (rats), 457

hormonal regulation of acetohexamide re-ductase, postnatal development, sex-related differences (rats), 166

inner medullary collecting duct cells, a!-

1502 Index Vol. 264

pha-2 adrenergic receptors (rabbits),879

micropuncture study, action of ICI 206,970 (rats), 604

microvascular actions of YM435 (rats),1154

postischemic vasoconstriction, interac-tion, thromboxane A2 and angioten-sin II (dogs), 1285

synthesis of dopamine, role of sodium(rats), 406

testosterone modulation of N-acetylation(mice), 854

tubular secretion and reabsorption, mer-cury compounds (mice), 776

King, T. S., Canez, M. S., Gaskill, S., Javors,M. A. and Schenken, H. S.: Chroniccocaine disruption of estrous cyclicityin the rat: Dose-dependent effects, 29

Kishel, M. T., see Pettibone, D. J., 308Koek, W., Colpaert, F. C. and Vignon, J.:

Effects of phencyclidine-type drugsin rats discriminating fentanyl from

saline: Pharmacological and behav-ioral characterization of intermediatelevels of drug lever selection, 746

Koob, G. F., see Negus, S. S., 739Kostka, P., Jang, E., Watson, E. G., Stewart,

J. L. and Daniel, E. E.: Nitric oxidesynthase in the autonomic nervoussystem of canine lleum, 234

Krecic, M. E., see Apseloff G., 1071Kroboth, P. D., Bertz, R. J. and Smith, H.

B.: Acute tolerance to triazolam dur-ing continuous and step infusions:Estimation of the effect offset rateconstant, 1047

Ku, D. D., see Winn, M. J., 265Kucharczyk, N., see McCabe, H. T., 1248Kuemmerle, J. F., see Morini, G., 598Kuenzli, K. A., see Bradley, M. E., 1033Kuhn, H., see Roux, S. P., 501Kuoppam#{228}ki, M., Sepp#{228}la,T., Syv#{228}lahti,E.

and Hietala, J.: Chronic clozapinetreatment decreases 5-hydroxytryptamine1c receptor den-sity in the rat choroid plexus: Com-parison with haloperidol, 1262

Kurumiya, S., see Oka, M., 158Kusano, E., see Homma, S., 105Kuster, J. E., Stevenson, J. I., Ward, S. J.,

D’Ambra, T. E. and Haycock, D. A.:

Aminoalkylindole binding in rat cer-ebellum: Selective displacement bynatural and synthetic cannabinoids,1352

Kwan, C.-Y., see Shimamoto, Y. :201

L 659,877, initiation of micturition reflex,peripheral role, tachykinins (rats),1327

Lai, H., see Prather, P. L., 622Landaw, E. M., see Cho, A. K., 1401Lane, J. D., see Prather, P. L., 622Lane, W. V., see Xie, Y., 689Lanfumey, L., see Kidd, E. J., 863Laniyonu, A., see Yang, S.-G., 958

Law, P. Y., see Bergsbaken, C. L., 1474Lawson, J. A., see DeGraff, G. L., 6Lead, inhibition of brain protein kinase C

subtypes (rats), 757Learning

latent, impairment by dopaminergic ago-nists (mice), 122

performance and subject ratings, acute

effects, triazolam and lorazepam (hu-mans), 1218

Lecchini, S., see de Ponti, F., 789Lecci, A., Giuliani, S., Patacchini, H. and

Maggi, C. A.: Evidence against a pe-ripheral role of tachykinins in theinitiation of micturition reflex inrats, 1327

Lee, H. S., see Balasubramaniam, G., 129Leeb-Lundberg, L. M. F., see Tropea, M.

M., 930Lehnert, S., see Alaoui-Jamali, M. A., 1299leMarouille-Girardon, S., see Millan, M. J.,

1364Lenham, J., see Breese, C. H., 448Leukocytes, amelioration of chronic ileitis,

nitric oxide synthase inhibition(rats), ii

Leukotrienesinflammatory mediators, electrolyte

transport, distal colon epithelium(pigs),61

neurally mediated actions, ion transport,distal colon (guinea pigs), 384

Levant, B., Grigoriadis, D. E. and DeSouza,E. B.: [3H]Quinpirole binding to pu-tative D2 and D3 dopamine receptorsin rat brain and pituitary gland: Aquantitative autoradiographic study,991

Levin, G., see Nowicki, S., 1377Levine, J. D., see Miao, F. J.-P., 839Levitin, M., see Lovinger, D. M., 1097Levy, G., see Hoffman, A., 859Li, Z. and Duckles, S. P.: Acute effects of

nicotine on rat mesenteric vascula-

ture and tail artery, 1305

Lidocaine, block of sodium channels, singleatrial cells (humans), 1275

Liewer, S. A., see Toews, M. L., 1211Ligands

-y-hydroxybutyrate, antidopaminergic

and neuroleptic-like activities, 1406sigma, neuropeptide Y and peptide YY,

ion transport in jejunum (mice), 1268Liljequist, S. and Tabakoff, B.: Bicuculline-

produced regional differences in themodulation of �S-TBPS binding byGABA, pentobarbital, and diazepamin mouse cerebellum and cortex, 638

Lillywhite, K. J., see Jin, C., 475Limberger, N., see Jackisch, H., 889Lin, A. M.-Y., Bickford, P. C. and Palmer,

M. H.: The effects of ethanol on r-

aminobutyric acid-induced depres-sions of cerebellar Purkinje neurons:Influence of beta adrenergic receptoraction in young and aged Fischer 344rats, 951

Lipid peroxidation, tert-butylhydroperox-ide-induced inhibition, endothelialcell calcium signaling (calves), 1063

Lipopolysaccharide, protective effect ofE3330, galactosamine-induced hepa-titis (rats), 496

5-Lipoxygenase, influence of epithelium,histamine release and contraction,tracheal strips (guinea pigs), 717

Lis, E. V., see Pettibone, D. J. , 308Liu, E. C. K., see Webb, M. L., 1387Liu, Z., Brien, J. F., Marks, G. S., Mc-

Laughlin, B. E. and Nakatsu, K.:Lack of evidence for the involvementof cytochrome P-450 or other hemo-proteins in metabolic activation of

glyceryl trinitrate in rabbit aorta,1432

Liveralteration of insulin metabolism, glybur-

ide and glipizide (rats), 1293cytochrome P450 isozymes, chronic

ethanol, growth hormone secretion(rats),438

hormonal regulation of acetohexamide re-ductase, postnatal development, sex-related differences (rats), 166

induction of cytochrome P450 2E1, pyra-zole and 4-methylpyrazole, neonates(rats),1468

regio- and stereoselective propranolol me-tabolism, 15 forms of cytochromesP450 (rats), 226

UDP-glucuronosyltransferase glucuroni-dating carboxylic acid-containing

drugs, complementary DNA cloningand expression (humans), 475

Liver microsomes, mono-N-dealkylationmetabolism of disopyramide, potentinhibitory effect, erythromycin andother macrolide antibiotics (hu-mans), 1425

Locus coeruleus, a!pha-2 adrenoceptor sub-types (humans), 967

Loeffler, H. F., see Gullikson, G. W., 240Lombardy, H. J., see Caughey, G. H., 676Long, J. B., see Dosaka-Akita, K., 631Lopaschuk, G. D., Wambolt, R B. and Barr,

H. L.: An imbalance between glycol-

ysis and glucose oxidation is a possi-ble explanation for the detrimentaleffects of high levels of fatty acidsduring aerobic reperfusion of is-chemic hearts, 135

Lorazepam, triazolam and, acute effects,learning and performance (humans),1218

Loring, H. H., see Xie, Y., 689Losartan, hormonal and cardiovascular ef-

fects (monkeys), 6Lovinger, D. M., Zimmerman, S. A., Levitin,

M., Jones, M. V. and Harrison, N. L.:Trichloroethanol potentiates synap-tic transmission mediated by -y-ami-

nobutyric acidA receptors in hippo-campal neurons, 1097

Lowensohn, H. I., see Pettibone, D.J., 308Luck, M. S. and Bass, P.: Effect of epider-

mal growth factor on experimentalcolitis in the rat, 984

Luedtke, H. H., see Boundy, V. A., 1002Lukas, S. E., see Mello, N. K., 530Lumpkin, C. K., see Badger, T. M., 438Lumpkin, C. K., see Ronis, M. J. J., 944Lundin, S., Broeders, A., Ohlin, M., Hans-

son, K., Bengtsson, H.-I., Trojnar, J.and Melin, P.: Pharmacokinetic andpharmacologic properties of antiuter-otonic oxytocin analogs in the rat,783

Lungantiallergic and bronchodilator effects,

isozyme-selective phosphodiesteraseinhibitors (guinea pigs), 609

eosinophilia, antigens, IgG1 sensitization(guinea pigs), 922

vascular bed, tone-dependent responses ofserotonin, different 5-HT receptors(cats), 1315

Lupus nephritis, glomerular thromboxanereceptors (mice), 584

1993 Index 1503

Luteinizing hormone, secretion in prepu-bescence, failure to reverse inhibitoryeffect of morphine, naloxone (rats),47

LY274614, attenuation and reversal, mor-phine tolerance (rats), 1090

Lytle, D. A., see Prather, P. L., 622

Mackenzie, P. I., see Jin, C., 475Macrolides, erythromycin and others, po-

tent inhibitory effect, mono-N-deal-kylation metabolism of disopyramide(humans), 1425

Macromolecules, 70-kilodalton fluorescein-dextran, pharmacokinetics, diabetes

mellitus (rats), 662Macrophages, morphine-induced suppres-

sion, cytokine reversal, antibody re-sponse (mice), 591

Maggi, C. A., see Holzer, P., 391Maggi, C. A., see Lecci A., 1327Maggi, C. A., see Patacchini, H., 17Mah, S. C., see Balasubramaniam, G., 129Manes, M. D., Mayer, H. D., Ewing, J. F.

and McCoubrey, W. K., Jr.: Induc-tion of kidney heme oxygenase-1(HSP32) mRNA and protein by is-chemia/reperfusion: Possible role ofheme as both promotor oftissue dam-age and regulator of HSP32, 457

Maitre, M., see Hechler, V., 1406Maixner, W., see Suarez-Roca, H., 648Makhlouf, G. M., see Morini, G., 598Manning, C. D., see Barnette, M. S., 801Maren, T. H., see Brechue, W. F., 670Mark, J., see Hechler, V., 1406Marks, G. S., see Liu, Z., 1432Marks, M. J., Farnham, D. A., Grady, S. H.

and Collins, A. C.: Nicotinic receptorfunction determined by stimulationof rubidium efflux from mouse brainsynaptosomes, 542

Martello, A. L., see Scanzello, C. H., 1484Martin, I., see Miralles, A., 1187Mast cells, tryptases, reversible inhibitors,

bis(5-amidino-2-benzimidazo-lyl)methane and related amidines(dogs), 676

Masuda, M., see Fujita, S., 226Mathis, D. A., see J#{228}rbe,T. U. C., 561Matot, I., see Neely, C. F., 1315Maxwell, D. M., Brecht, K. M., Doctor, B.

P. and Wolfe, A. D.: Comparison ofantidote protection against soman bypyridostigmine, Hl-6 and acetylcho-linesterase, 1085

Mayer, H. D., see Manes, M. D., 457McCabe, R T., Wasterlain, C. G., Kuchar-

czyk, N., Sofia, H. D. and Vogel, J.R.: Evidence for anticonvulsant andneuroprotectant action of felbamatemediated by strychnine-insensitiveglycine receptors, 1248

McCoubrey, W. K., Jr., see Manes, M. D.,457

McDonald, D. M., see Petersson, G., 509McKelvy, J. F., see Firestone, J. A., 1206Mckinney, M., Miller, J. H. and Aagaard,

P. J.: Pharmacological characteriza-tion of the rat hippocampal musca-rinic autoreceptor, 74

McLaughlin, B. E., see Liu, Z., 1432MDL 72832, MDL 73005 EF and, induction

ofhypothermia, 5-HT1A receptor-me-diated activity (rats), 1364

Mechoulam, H., see J#{225}rbe,T. U. C., 561

Meclofenamate, adenosine-stimulated con-traction, lack of cyclo-oxygenase in-volvement, nonpregnant myomet-rium (guinea pigs), 1033

Meglasson, M. D., see Ohta, M., 35Mehta, M., see Gallo, J. M., 315Mehvar, H. and Reynolds, J. M.: Pharma-

cokinetics of 70-kilodalton fluores-cein-dextran in experimental diabe-tes mellitus, 662

Melin, P., see Lundin, S., 783Mello, N. K., Kamien, J. B., Lukas, S. E.,

Mendelson, J. H., Drieze, J. M. andSholar, J. W.: Effects of intermittentbuprenorphine administration on co-caine self-administration by rhesusmonkeys, 530

Memory, short-term, delayed match to sam-ple performance, 6-9-tetrahydrocan-nabinol (rats), 294

Mendelson, J. H., see Mello, N. K., 530Mephenytoin, stereoselective metabolism of

cytochrome P450, species differences(rats, rabbits, dogs, monkeys, hu-mans), 89

Mercado, C., see Badger, T. M., 438Mercado, C., see Ronis, M. J. J., 9446-Mercaptopurine, S-(6-puri-

nyl)glutathione and, mechanisms of

formation, 6-chloropurine (rats), 41Mercury compounds, metallothionein and,

tubular secretion and reabsorption,kidney (mice), 776

Methacholinealteration in modulatory role, respiratory

epithelium, exposure to cotton dust(guinea pigs), 683

contractile effects of nucleotides, trachea(guinea pigs), 210

relaxant effects of nucleotides, trachea(guinea pigs), 217

Methamphetamine, impairment of latentlearning (mice), 122

Methoxy-chroman derivatives, agonistproperties, central 5-HT1A receptors(rats), 863

N-Methyl-D-aspartate

antagonists, discriminative stimulus ef-fects, ethanol (rats), 1241

-evoked release from cortical slices, cho-linergic modulation (rats), 282

excitatory amino acid agonists, dipsogeniceffects (pigeons), 918

receptor antagonist, dopamine D1 and D2agonist interactions, i-methyl-4-phenyl-1,2,5,6-tetrahydropyridineinduction (monkeys), 221

Methyl chloroform, 1,1,1-trichloroethane-produced physical dependence, ef-fects of drugs and vapors, withdrawal(mice), 726

3,4-Methylenedioxymethamphetamine, in-jury, serotonergic recovery (rats),1484

1-Methyl-4-phenyl-1,2,5,6-tetrahydropyri-

dine, induction, NMDA receptor an-tagonist, dopamine D1 and D2 agonistinteractions (monkeys), 221

4-Methylpyrazole, pyrazole and, inductionof liver cytochrome P450 2E1, neo-nates (rats), 1468

5-Methyltryptamine, tracheal contractileserotonergic receptor, 5-HT2 receptor(guinea pigs), 271

Methysergide, rauwolscine, contraction in

mesenteric artery, precontractionwith KC1 and endothelin-1 (dogs),201

Mexiletine, interaction of sodium and po-tassium channel blockers, papillarymuscle (guinea pigs), 1056

Miao, F. J.-P., Dallman, M. F., Benowitz,N. L., Basbaum, A. I. and Levine, J.D.: Adrenal medullary modulation ofthe inhibition of bradykinin-inducedplasma extravasation by intrathecalnicotine, 839

Microvasculature, renal, actions of YM435(rats), 1154

Micturition reflex, initiation of, peripheralrole, tachykinins (rats), 1327

Midazolam, i,1,i-trichloroethane-producedphysical dependence, effects of drugsand vapors, withdrawal (mice), 726

Mignot, B., see Nishino, S., 1079Migrating myoelectric complex, intestinal

motility, differential effects, anti-muscarinic agents (dogs), 789

Millan, M. J., Rivet, J.-M., Canton, H.,leMarouille-Girardon, S. and Gobert,A.: Induction of hypothermia as amodel of 5-hydroxytryptaminelA re-ceptor-mediated activity in the rat: Apharmacological characterization ofthe actions of novel agonists and an-tagonists,1364

Millan, M. J., see Bervoets, K., 95Miller, J. H., see Mckinney, M., 74Miller, M. J. S., Sadowska-Krowicka, H.,

Chotinaruemol, S., Kakkis, J. L. andClark, D. A.: Amelioration of chronicIleitis by nitric oxide synthase inhi-bition, ii

Miller, H. J., see Rhim, H., 795

Miners, J. 0., see Jin, C., 475Minkes, H. K., see Osei, S. Y., 1104

Miralles, A., Olmos, G., Sastre, M., Barth-ren, F., Martin I. and Garcia-Sevilla,J. A.: Discrimination and pharmaco-logical characterization of 12-imida-zoline sites with [3Hlldazoxan andalpha-2 adrenoceptors with [3H]RX821002 (2-methoxy idazoxan) inthe human and rat brains, 1187

Miramatsu, M., see Cho, A. K., 1401Misra, H. N., see Ogletree, M. L., 570Misra, H. N., see Webb, M. L., 1387Miyamoto, K., see Nagakawa, J.-I., 496Miyamoto, Y., Portoghese, P. 5. and Take-

mori, A. E.: Involvement of Delta2opioid receptors in the developmentof morphine dependence in mice,1141

MK8O1attenuation and reversal of morphine tol-

erance, LY274614 (rats), 1090

1-methyl-4-phenyl-1,2,5,6-tetrahydropyr-idine induction, NMDA receptor an-tagonist, dopamine D1 and D2 agonistinteractions (monkeys), 221

Moghaddam, B., see Youngren, K. D., 289Molinoff, P. B., see Boundy, V. A., 1002NG�Monomethyl�L�arginine, Nw nitro L-ar-

ginine methyl ester and, vasomotorresponses, coronary arterial rings(dogs), 265

Monshizadegan, H., see Webb, M. L., 1387Moore, B. W., see Nock, B., 349Morini, G., Kuemmerle, J. F., Impicciatore,

M., Grider, J. H. and Makhlouf, G.

1504 Index Vol. 264

M.: Coexistence of histamine H1 andH2 receptors coupled to distinct sig-nal transduction pathways in isolatedintestinal muscle cells, 598

Morita, H., see Ueki, S., 152Morphine

attenuation and reversal of tolerance,LY274614 (rats), 1090

brief exposure, withdrawal responses inileum, effects of NSAIDs (guineapigs), 1028

development of dependence, involvement,delta-2 opioid receptors (mice), 1141

failure to reverse inhibitory effect, nalox-one, luteinizing hormone secretion inprepubescence (rats), 47

-induced suppressioncytokine reversal, antibody response

(mice), 591splenocyte natural killer activity, aipha

adrenergic and mu-2 opioid recep-tors, 1179

U-50,488H and, activation ofkappa opioidreceptors, substance P release (rats),648

Morrone, L. A., see Valeri, P., 1028Mosberg, H. I., see Wild, K. D., 831Moummi, C., see Gullikson, G. W., 240Mounier, C., Hatmi, M., Faili, A., Bon, C.

and Vargaftig, B. B.: Competitive in-hibition of phospholipase A2 activityby the platelet-activating factor an-tagonist Ho 19-3704 and evidence fora novel suppressive effect on plateletactivation, 1460

Moxonidine, selective ligand for 11-imida-zoline sites (cattle), 172

Mr2033, respiratory depressant effects, ap-parent pA2 analysis (monkeys), 145

Mucosa, nasal, neurogenic plasma extrava-sation, peptidase inhibitors (rats),509

Munson, A. E., see Burns, L. A., 695Murakami, K., Feng, G. and Chen, S. G.:

Inhibition of brain protein kinase Csubtypes by lead, 757

Murayama, N., see Homma, S., 105Murray, T. F., see Zhang, G., 1415Muscle

papillary, interaction, sodium and potas-sium channel blockers (guinea pigs),1056

retardation of atrophy, aminohydroxybu-tane bisphosphonate and clenbuterol,tail-suspended rats, 1071

rigidity, alfentanil-induced antinocicep-tion, fl-funaltrexamine and naloxon-azine (rats), 739

Muscle, smoothantiuterotonic oxytocin analogs, phar-

macokinetic and pharmacologicproperties (rats), 783

colonic, cyclic nucleotide phosphodiester-ase isozymes (dogs), 801

gastric, distinct signal transduction path-ways, angiotensin II (guinea pigs),958

intestine, histamine H1 and H2 receptors,signal transduction pathways (guineapigs), 598

mesenteric vasculature, acute effects ofnicotine, tail artery (rats), 1305

superior mesenteric artery, Bi and B2kinin receptors (rabbits), 930

vascular, serotonin-induced contraction,coronary artery (pigs), 193

Myeloperoxidase, epidermal growth factor,experimental colitis (rats), 984

Myocardial ischemia, protection from in-jury, stimulation of endogenous pros-tacyclin (pigs), 397

Myocytesatrial, potassium channel blocking prop-

erties, propafenone (rabbits), 1113cardiac, alterations of calcium dynamics,

U46619 (rats), 336ventricular

4-aminopyridine block, transient out-ward K� current (rats), 1450

two delayed rectifiers, tail current ki-netics (guinea pigs), 553

Myometrium, nonpregnant, adenosine-stimulated contraction, lack of cyclo-oxygenase involvement (guinea pigs),1033

Nabeshima, T., see Ichihara, K., 122Na�-Ca�� exchanger, inhibition enhances

anoxia and glucopenia-induced as-partate release, hippocampal slices(rats), 515

Nadel, J. A., see Petersson, G., 509

Nagakawa, J.-I., Hirota, K., Hishinuma, I.,Miyamoto, K., Sonoda, J., Yaman-aka, T., Katayama, K-I. and Ya-matsu, I.: Protective effect of E3330,a novel quinone derivative, in galac-tosamine-induced hepatitis in rats,496

Naganuma, A., see Tanaka-Kagawa, T., 776Nagata, K., see Yasumori, T., 89Nakamura, N., see Kaechi, K., 321Nakane, T. and Chiba, S.: Pharmacological

analysis of vasodilation induced byextracellular adenosine 3 ‘ ,5 ‘ -cyclicmonophosphate in the isolated andperfused canine coronary artery,1253

Nakatsu, K., see Liu, Z., 1432Naloxonazine, $-funaltrexamine and, alfen-

tanil-induced antinociception, mus-cle rigidity (rats), 739

Naloxonedevelopment of morphine dependence, in-

volvement, delta-2 opioid receptors(mice), 1141

failure to reverse inhibitory effect of mor-phine, luteinizing hormone secretion,prepubescence (rats), 47

-resistant receptors for fl-endorphin, pro-tein kinase C activation, U937 cells,276

Naltrexone, differential antagonism, hydro-morphone and pentazocine effects(humans), 813

Naltriben, development of morphine de-pendence, involvement, delta-2opioid receptors (mice), 1141

Nambi, P., Pullen, M., Jugus, M. and Gellai,M.: Rat kidney endothelin receptorsin ischemia-induced acute renal fail-ure, 345

Narahashi, T., see Heuveny, E., 22Narcolepsy, control of cataplexy, aipha-i

receptor subtype (dogs), 1079Nassar, H., see Wolf, M. E., 249Nattel, S., see Duan, D., 1113Nattel,S.,seeRanger,S., 1160Natural killer cells, splenocyte activity,

morphine-induced suppression, alpha

adrenergic and mu-2 opioid recep-tors, 1179

Neely, C. F., Haile, D. and Matot, I.: Tone-dependent responses of 5-hydroxy-tryptamine in the feline pulmonaryvascular bed are mediated by two dif-ferent 5-hydroxytryptamine recep-tors, 1315

Negus, S. S., Pasternak, G. W., Koob, G. F.and Weinger, M. B.: Antagonist ef-fects of fl-funaltrexamine and nalox-onazine on alfentanil-induced antin-ociception and muscle rigidity in therat, 739

Nelson, D., see Ohta, M., 35Nelson, J., see Ohta, M., 35Neostigmine, survival during hypoxia, gen-

der differences (mice), 1146Nephron, connecting tubules, coupling of

beta-i and beta-2 adrenoceptors,cyclic AMP system (rabbits), 105

Nereistoxin, redox effects, neuronal nico-tinic acetylcholine receptors, retina(chicks), 689

Nervecholinergic and noncholinergic, mu and

alpha-2 receptors (guinea pigs), 375phrenic, diaphragm, effect of arachidonic

acid on twitch tension (rats), 1311renal, antinatriuresis, suppression by

TMB-8 (dogs), 117Nerve growth factor, physiologically active,

pharmacological induction, periph-eral nervous system (rats), 321

Netter, P., see Ferrari, L., 1012Neuroblastoma, desensitization and down-

regulation, neurotensin(8-13), neu-rotensin receptors (mice), 1

Neuroblastoma cellsblock of two types of calcium channels,

chlordiazepoxide (mice), 22chronic etorphine-induced sensitization,

adenylyl cyclase, buprenorphine pre-vention and reversal, 368

Neurokinin, peripheral role of tachykinins,initiation, micturition reflex (rats),

1327Neurokinin A

derivatives and agonist and antagonistproperties, biological activity, C-ter-minal amidation (guinea pigs, rab-bits, hamsters, rats), 17

tachykinins and acetylcholine, ascendingenteric reflex contraction (guineapigs),391

Neurones, serotonergic, 5-HT1A receptors,tail-flick response (rats), 95

Neuronscerebellar Purkinje, ethanol effects, r-

aminobutyric acid-induced depres-sion (rats), 951

dopamine, electrophysiological effects, di-phenylpyrazolidinone cholecystoki-nm-B and -A antagonists (rats), 480

hippocampal, trichloroethanol-poten-tiated synaptic transmission, media-tion by GABAA receptors, 1097

nigrostriatal, role of forebrain, repeatedamphetamine administration (rats),616

pharmacological induction, physiologi-cally active nerve growth factor(rats), 321

serotonergic recovery, 3,4-methylene-

1993 Index 1505

(rats),1484Neuropeptide Y, peptide YY and sigma li-

gands, ion transport, jejunum (mice),

1268Neurotensin, desensitization and down-reg-

ulation, neurotensin receptors, N1E-115 cells (mice), 1

Neurotoxicity, theophylline, adrenalectomy,kinetics of drug action in diseasestates (rats), 859

Neurotransmissionatrial natriuretic factor, guanylate cy-

clase-coupled receptors, vas deferens(rabbits), 1227

norepinephrine uptake and release, ac-tions of A-7500, bovine adrenal chro-maffin cells, 1206

NeurotransmitterNMDA-evoked norepinephrine release,

cholinergic modulation, corticalslices (rats), 282

release, budipine effects, central nervoussystem tissue (rabbits), 889

Neutrophils, stimulation of endogenousprostacyclin, protection from injury,myocardium (pigs), 397

NG1O8-i5 cells, delta opioid receptor activ-ity, forskolin and isobutylmethylxan-thine, 1474

Nicotineacute effects, mesenteric vasculature, tail

artery (rats), 1305intrathecal, adrenal medullary modula-

tion, bradykinin-induced plasma ex-travasation (rats), 839

Nifedipinecocaine sensitization of coronary artery

contractions, mechanism, drug-in-duced spasm (cattle), 1132

energy level and stimulated insulin secre-

tion, islets of Langerhans (rats), 35renal nerve stimulation-induced antina-

triuresis, suppression by TMB-8(dogs), 117

Nimodipine, zidovudine kinetics (monkeys),315

Nirei, H., see Sogabe, K., 1040Nishino, S., Fruhstorfer B., Arrigoni, J.,

Guilleminault, C., Dement, W. C. andMignot, E.: Further characterizationof alpha-i receptor subtype involvedin the control of cataplexy in caninenarcolepsy, 1079

Nitric oxide synthaseautonomic nervous system of ileum

(dogs), 234

inhibition, amelioration, chronic ileitis(rats), 11

Nw Nitro L-arginine methyl ester, NG�mon�omethyl-L-arginine and, vasomotorresponses, coronary arterial rings(dogs), 265

Nizatidine, gastroprokinetic activity (dogs,rats), 152

Nock, B., Giordano, A. L., Moore, B. W.and Cicero, T. J.: Properties of theputative epsilon opiod receptor: Iden-tification in rat, guinea pig, cow, pigand chicken brain, 349

Nock, B., see Cicero, T. J., 47Noda, Y., see Oka, M., 158Nomifensine, impairment of latent learning

(mice), 122

Nomoto, A., see Sogabe, K., 1040

injury Noradrenalinebudipine effects, neurotransmitter re-

lease, central nervous system tissue(rabbits), 889

inhibition of release from stomach, cho-linergic M2 muscarinic receptors(rats), 54

Norepinephrineneurally mediated action of leukotrienes,

ion transport, distal colon (guinea

pigs), 384

NMDA-evoked release, cholinergic mod-ulation, cortical slices (rats), 282

release in paraventricular nucleus/ante-nor hypothalamus, histamine (rats),734

uptake and release, actions of A-75200,bovine adrenal chromaffin cells, 1206

Notsu, V., see Sogabe, K., 1040Novy, M. J., see Pettibone, D. J., 308Nowicki, S., Levin, G. and Enero, M. A.:

Involvement of renal dopamine syn-thesis in the diuretic effect of furo-semide in normohydrated rats, 1377

NPC 17742, pharmacological profile (rats,mice, gerbils), 256

NSAIDs, withdrawal responses in ileum,brief exposure to morphine (guineapigs), 1028

Nucleosides, nimodipine effect, zidovudinekinetics (monkeys), 315

Nucleotidesadenosine triphosphate and, tone, mes-

enteric resistance arteries (rats),1234

contractile effects, trachea (guinea pigs),210

modulation of low affinity binding sites,glibenclamide, brain (rats), 701

relaxant effects, trachea (guinea pigs), 217Nucleotides, cyclic, phosphodiesterase iso-

zymes, colonic smooth muscle (dogs),801

Nucleus accumbensautoreceptor subsensitivity, enhanced do-

pamine release, amphetamine sensi-tization (rats), 249

outflow of dopamine, distinct actions, en-dogenous excitatory amino acids(rats), 289

Nucleus tractus solitarius, modulation of af-ferent transmission, selective opioidagonists (rats), 795

Ochi, Y., see Oka, M., 158

O’Connor, L., see Cicero, T. J, 47O’Donnell, J. M.: Antidepressant-like ef-

fects of rolipram and other inhibitorsof cyclic adenosine monophosphatephosphodiesterase on behavior main-tamed by differential reinforcementof low response rate, 1168

Ogasawara, A., Hisa, H. and Satoh, S.: Anintracellular calcium release inhibi-tor TMB-8 suppresses renal nervestimulation-induced antinatriuresisin dogs, 117

Ogawa, Y., see Kamei, S., 469Ogletree, M. L., Harris, D. N., Schumacher,

W. A., Webb, M. L. and Misra, H. N.:Pharmacological profile of BMS 180,

291: A potent, long-acting, orally ac-tive thromboxane A2/prostaglandinendoperoxide receptor antagonist,570

O’Grady, S. M., see Traynor, T. H., 61

8-OH-DPAT5-HT1A receptors and tail-flick response

(rats), 95induction of hypothermia, 5-HT,A recep-

tor-mediated activity (rats), 1364

Ohlin, M., see Lundin, S., 783

Ohta, M., Nelson, J., Nelson, D., Meglasson,M. D. and Ereci#{241}ska, M.: Effect ofCa� channel blockers on energy leveland stimulated insulin secretion inisolated rat islets of langerhans, 35

Oka, M., Noda, Y., Ochi, Y., Furukawa, K.,Une, T., Kurumiya, S., Hino, K. andKarasawa, T.: Pharmacological pro-file ofAD-5423, a novel antipsychoticwith both potent dopamine-D2 andsenotonin-S2 antagonist properties,

158

Okada, H., see Kamei, S., 469Oliveto, A. H., see Bickel, W. K., 360Olmos, G., see Miralles, A., 1187Omae, F., see Kaechi, K., 321Ondansetron, conflicting evidence regarding

efficacy, benzodiazepine withdrawal(rats),622

Ono, T., see Sogabe, K., 1040Onorato, J. J., see Spurney, H. F., 584

Opiates, failure to reverse inhibitory effectof morphine, naloxone, luteinizinghormone secretion in prepubescence(rats), 47

Opioidsagonists, modulation of afferent transmis-

sion, nucleus tractus solitarius (rats),795

differential naltrexone antagonism, hy-dromorphone and pentazocine effects(humans), 813

intermittent buprenorphine administra-tion, cocaine self-administration(monkeys), 530

morphine-induced suppression, cytokinereversal, antibody response (mice),591

motivational sites, neuroanatomical sites,conditioned place preference para-

digm (rats), 489

mu and a!pha-2 receptors, enteric nerves(guinea pigs), 375

properties of epsilon opioid receptor, brain(rats, guinea pigs, cows, pigs, chick-ens), 349

respiratory depressant effects, apparentpA2 analysis (monkeys), 145

Ordway, G. A., Jaconetta, S. M. and Halanis,

A. E.: Characterization of subtypes ofalpha-2 adrenoceptors in the humanbrain, 967

Organophosphorus compounds, comparisonof antidote protection against soman,pyridostigmine, HI-6 and acetylcho-

linesterase, 1085

Osei, S. Y., Minkes, H. K., Bellan, J. A. andKadowitz, P. J.: Analysis of the in-hibitory effects of DuP 753 and EXP3174 on responses to angiotensin IIin the feline hindquarters vascularbed, 1104

Osumi, Y., see Yokotani, K., 54Otagiri, M., see Imamura, Y., 166Ouabain, synthesis of dopamine in kidney,

role of sodium (rats), 406Ovalbumin, histamine release and contrac-

tion, influence ofepithelium, trachealstrips (guinea pigs), 717

1506 Index Vol. 264

Ovulation, chronic cocaine disruption, es-trous cyclicity, dose-dependent ef-fects (rats), 29

Oxime, comparison of antidote protectionagainst soman, pyridostigmine, HI-6and acetylcholinesterase, 1085

Oxytocin, orally active nonpeptidyl, antag-onist (rats), 308

Oxytocin analogs, antiuterotonic, pharma-cokinetic and pharmacologic proper-ties (rats), 783

Pain5-HT1A receptors and tail-flick response

(rats), 95sensitivity, adrenalectomy, kinetics of

drug action in disease states (rats),

859

Palmer, M. H., see Lin, A. M.-Y., 951Pals, D. T., see DeGraff, G. L., 6Pancreas

acini, exocytotic function, FK506 char-acterization and effects (rats), 873

islets of Langerhans, Ca� channel block-ers, energy level and stimulated in-sulin secretion (rats), 35

Parathyroid hormone, calcemic hormone-and growth factor-based bone resorp-tion, suramin as inhibitor (mice), 579

Parkinson’s disease1-methyl-4-phenyl-1,2,5,6-tetrahydropyr-

idine induction, NMDA receptor an-tagonist, dopamine D1 and D2 agonistinteractions (monkeys), 221

neurotransmitter release, budipine ef-fects, central nervous system tissue

(rabbits), 889Pascaud, X., see Hiviere, P. J. M., 1268Pasternak, G. W., see Negus, S. S., 739Patacchini, H., Quartara, L., Rovero, P.,

Goso, C. and Maggi, C. A.: Role of c-terminal amidation on the biologicalactivity of neurokinin a derivativeswith agonist and antagonist proper-ties,, 17

Patacchini, H., see Lecci A., 1327Patch, H. J., see Ferkany, J. W., 256Patch-clamp

block of two types of calcium channels,chlordiazepoxide, neuroblastomacells (mice), 22

two delayed rectifiers, ventricular myo-cytes, tail current kinetics (guineapigs), 553

Paul, D., see Carr, D. J. J., 1179Pentamidine, bis(5-amidino-2-benzimida-

zolyl)methane, reversible inhibitors,mast cell tryptases (dogs), 676

Pentazocine, hydromorphone and, differ-ential naltrexone antagonism (hu-mans), 813

Pentobarbital, modulation of �S-TBPSbinding, bicuculline-produced re-gional differences, cerebellum andcortex (mice), 638

Pentylenetetrazole, benzodiazepine with-drawal, conflicting evidence regard-ing efficacy, ondansetron (rats), 622

Peptidase, inhibitors, neurogenic plasma ex-travasation, nasal mucosa (rats), 509

Peptide YY, neuropeptide Y and sigma li-gands, ion transport, jejunum (mice),1268

Peptidoleukotrienes, histamine release andcontraction, influence of epithelium,tracheal strips (guinea pigs), 717

Peripheral nervous system, pharmacologicalinduction, physiologically activenerve growth factor (rats), 321

Pertussis toxin, inhibition of noradrenalinerelease from stomach, cholinergic M2muscarinic receptors (rats), 54

Pestana, M., see Soares-[da]-Silva, P., 406Peter, P., see Hechler, V., 1406Peterlik, M., see Farsoudi, K. H., 579Petersson, G., Bacci, E., McDonald, D. M.

and Nadel, J. A.: Neurogenic plasmaextravasation in the rat nasal mucosais potentiated by peptidase inhibi-tors, 509

Pettibone, D. J., Clineschmidt, B. V.,Kishel, M. T., Lis, E. V. Reiss, D. H.,Woyden, C. J., Evans, B. E., Freidin-ger, H. M., Veber, D. F., Cook, M. J.,Haluska, G. J., Novy, M. J. and Low-ensohn, H. I.: Identification of an or-ally active, nonpeptidyl oxytocin an-tagonist, 308

Phencyclidineattenuation and reversal of morphine tol-

erance, LY274614 (rats), 1090-type drugs, discrimination of fentanyl

from saline (rats), 746Phencyclidine hydrochloride, discrimina-

tive stimulus effects ofethanol, train-

ing dose, NMDA antagonists (rats),

1241Phenobarbital, kinetics of drug action in

disease states, adrenalectomy, painsensitivity (rats), 859

i-Phenylbiguanide, m-chlorophenylbiguan-ide and, behavioral effects (rats),1440

Phenylcyclohexyldiethylamine, phenylcy-clohexylethylamine and, behavioraland pharmacokinetic study (rats),1401

Phorbol myristate acetate, activation of pro-tein kinase C, down-regulation ofnaloxone-resistant receptors, (3-en-dorphin, 276

Phosphodiesterasedecreased sensitivity to cAMP, genera-

tion, memory splenic cytotoxic T-lymphocytes, 1381

isozymes, cyclic nucleotides, colonicsmooth muscle (dogs), 801

isozyme-selective inhibitors, pulmonaryantiallergic and bronchodilator ef-fects (guinea pigs), 609

Phosphoinositide, turnover, muscarinic re-ceptor, tetrahydroaminoacridine(rats), 463

Phospholipase A2competitive inhibition by Ho 19-3704,

suppressive effect, platelet activation(rabbits),1460

distinct signal transduction pathways, an-giotensin II, gastric smooth muscle(guinea pigs), 958

Phospholipase C, activation by carbachol incortical slices, differential effects ofalkylating agents, muscarinic recep-

ton subtypes (rats), 521

Phosphoramidon, peptidase inhibitors, neu-rogenic plasma extravasation, nasalmucosa (rats), 509

Physostigmine, survival during hypoxia,gender differences (mice), 1146

Pietschmann, P., see Farsoudi, K. H., 579Pillar, J. S., see Chen, J. B., 922

Pilocarpine, survival during hypoxia, genderdifferences (mice), 1146

Pirenzepine, autoradiographic mapping, M3muscarinic receptors, brain (rats),

415Pisetsky, D. S., see Spurney, H. F., 584Pitts, D. K., Kelland, M. D., Freeman, A. S.

and Chiodo, L. A.: Repeated amphet-amine administration: Hole of fore-brain in reduced responsiveness ofnigrostriatal dopamine neurons todopamine agonists, 616

Pituitarycell line GH3, somatostatin receptor sub-

types (rats), 110quinpirole binding, dopamine D2 and D3

receptors (rats), 991Plasma, distributional transport kinetics of

zidovudine, brain extracellular fluid,cerebrospinal fluid (rabbits), 899

Plasminogen activatortissue-type

optimized thrombolysis, cerebral clots(rabbits),67

thrombolysis, heparin/aspirin/Ro 43-5054 (dogs), 501

Plateletsbinding and function of BMS 180,291

(humans), 1387stimulation of endogenous prostacyclin,

protection from ischemic injury,myocardium (pigs), 397

suppressive effect on activation, Ho 19-3704, competitive inhibition of phos-pholipase A2 activity (rabbits), 1460

Plesnen, L., see Juul, B., 1234Porreca, F., see Riviere, P. J. M., 1268Porreca, F., see Wild, K. D., 831

Portoghese, P. S., see Miyamoto, Y., 1141Portoghese, P. S., see Wild, K. D., 831Potassium

-induced cytosolic-free Ca�� signals, ef-fects of caffeine, adrenal chromaffincells (pigs), 770

modulation of afferent transmission, se-lective opioid agonists, nucleus trac-tus solitarius (rats), 795

Potassium channel blockerproperties of propafenone, atrial myo-

cytes (rabbits), 1113sodium channel blockers and, interaction,

papillary muscle (guinea pigs), 1056Potassium channels, modulation of low af-

finity binding sites, nucleotides andglibenclamide, brain (rats), 701

Potassium chloride, precontraction, con-traction with rauwolscine, mesen-teric artery (dogs), 201

Potassium current

transient outward, 4-aminopyridineblock, ventricular myocytes (rats),1450

two delayed rectifiers, ventricular myo-cytes, tail current kinetics (guineapigs), 553

Pnather, P. L., Rezazadeh, S. M., Lane, J.D., Rowan, G. A., Hooper, M. L.,Lytle, D. A., Emmett-Oglesby, M. W.and Lai, H.: Conflicting evidence re-garding the efficacy of ondansetron

in benzodiazepine withdrawal, 622Prednisolone, epidermal growth factor, ex-

perimental colitis (rats), 984Pregnancy, orally active nonpeptidyl oxy-

tocin antagonist (rats), 308

1993 Index 1507

Prepiriform cortex, manipulation of endog-enous adenosine, seizure susceptibil-ity (rats), 1415

Preston, K. L. and Bigelow, G. E.: Differ-ential naltrexone antagonism of hy-dromorphone and pentazocine effectsin human volunteers, 813

Price, W. J., see Barnette, M. S., 801Probenecid, distributional transport kinet-

ics, zidovudine, brain extracellularfluid/cerebrospinal fluid (rabbits),899

Prolactin, chronic cocaine disruption, es-trous cyclicity, dose-dependent ef-fects (rats), 29

Propafenone, potassium channel blockingproperties, atrial myocytes (rabbits),1113

Propranolol, regio- and stereoselective me-tabolism, 15 forms of purified cyto-chromes P450, liver (rats), 226

Prostacyclin, endogenous, protection fromischemic injury, myocardium (pigs),397

Prostaglandin E1, effects of NSAIDs, with-drawal responses in ileum, brief ex-posure to morphine (guinea pigs),1028

Prostaglandin endoperoxide, receptor an-tagonist BMS 180,291, pharmacolog-ical profile (humans, rats, cattle,mice, pigs, guinea pigs), 570

Prostaglandinscontractile effects of nucleotides, trachea

(guinea pigs), 210inflammatory mediators, electrolyte

transport, distal colon epithelium(pigs), 61

Prostanoidscontractile effects of nucleotides, trachea

(guinea pigs), 210neurally mediated action of leukotrienes,

ion transport, distal colon (guineapigs), 384

relaxant effects of nucleotides, trachea(guinea pigs), 217

Protein kinase Cactivation, down-regulation of naloxone-

resistant receptors, (3-endorphin, 276subtypes, inhibition by lead, brain (rats),

757

Proud, D., Reynolds, C. J., Broomfield, J.,Goldman, D. W. and Bathon, J. M.:Bradykinin effects in guinea pig tra-cheat epithelial cells are mediatedthrough a B2 kinin receptor and canbe inhibited by the selective antago-nist Hoe 140, 1124

Puberty, luteinizing hormone secretion, fail-ure to reverse inhibitory effect ofmorphine, naloxone (rats), 47

Pullen, M., see Nambi, P., 345S-(6-Purinyl)glutathione, 6-mercaptopu-

rine and, mechanisms of formation,6-chloropurine (rats), 41

Pyrazole, 4-methylpyrazole and, inductionof liver cytochrome P450 2E1, neo-nates (rats), 1468

Pyridostigmine, HI-6 and acetylcholinester-ase, comparison of antidote protec-tion, soman, 1085

Pyrilamine, histamine release and contrac-tion, influence ofepithelium, trachealstrips (guinea pigs), 717

Qian, M., see Gallo, J. M., 315

Quartara, L., see Patacchini, R., 17Quinpirole

binding to D2 and D3 dopamine receptors,brain and pituitary gland, autoradi-ography (rats), 991

comparisons with B-HT 920 and SND919, striatal dopamine and acetylcho-line release, 1344

Rabin, H. A.: Ethanol-induced desenitiza-tion of adenylate cyclase: Role of theadenosine receptor and GTP-bindingproteins, 977

Ranger, S., Sheldon, H., Fermini, B. andNattel, S.: Modulation of felcainide’scardiac sodium channel blocking ac-tions by extracellular sodium: A pos-sible cellular mechanism for the ac-

tion of sodium salts in flecainide car-diotoxicity, 1160

Rao, H. K., see Riviere, P. J. M., 1268Rasmussen, K., Czachura, J. F., Stockton,

M. E. and Howbert, J. J.: Electro-physiological effects of diphenylpyr-azolidinone cholecystokinin-B andcholecystokinin-A antagonists onmidbrain dopamine neurons, 480

Rauwolscine, contraction in mesenteric ar-tery, precontraction with KC1 andendothelin-i (dogs), 201

Hayford, P. L., see Doi, H., 873Raymond, W. W., see Caughey, G. H., 676Raynor, K. and Reisine, T.: Subtypes of

somatostatin receptors are expressedin the anterior pituitary cell GH3, 110

Receptorsbinding, enantiomenic pairs of cannabi-

noids, discriminative stimulus effects(rats, pigeons), 561

B2 kinin, bradykinin effects, inhibition byHoe 140 (guinea pigs), 1124

cannabinoid, aminoalkylindole binding,

cerebellum (rats), 1352cholinergic M2 muscarinic, inhibition of

noradrenaline release, stomach(rats), 54

dopamine, role of forebrain, repeated am-phetamine administration (rats), 616

dopamine D1, autoradiographic localiza-tion, kidney (humans), 431

dopamine D2, ipsilateral rotations, AF64Alesions of striatum (mice), 824

dopamine D3, pharmacologic properties,development of antibodies (rats),1002

dopamine D2 and D3, quinpirole binding,brain and pituitary gland (rats), 991

endothelin, ischemia-induced acute renalfailure (rats), 345

FK5OG characterization and effects, exo-cytotic function, pancreatic acini

(rats), 873

GABAA, trichloroethanol-potentiatedsynaptic transmission, hippocampalneurons, 1097

GABAB and muscarinic m3, seven trans-membrane spanning regions, anti-sense oligodeoxynucleotide to mes-senger HNAs (rats), 423

glycine, anticonvulsant and neuroprotec-tant action, felbamate, 1248

glycoprotein antagonist, thrombolysis,coronary artery reperfusion and reoc-clusion (dogs), 501

guanylate cyclase-coupled, altered neuro-

transmission, atnial natniuretic factor

(rabbits),1227

H2 antagonist, gastroprokinetic activity,nizatidine (dogs, rats), 152

histamine H1 and H2, signal transductionpathways, intestinal muscle cells(guinea pigs), 598

5-HTcisapride and 5-hydroxytryptamine,

motility in antrum (dogs), 79endothelial relaxing, jugular vein (rats),

709

pharmacological profile of AD-5423(mice, rats), 158

rauwolscine, contraction in mesentenic

artery (dogs), 201tone-dependent responses of serotonin,

vascular bed (cats), 13155-HT2

acute and chronic hypertensive mech-anism, ketansenin (rats), 129

tracheal contractile receptor (guineapigs), 271

5-HT3, agonists 1-phenylbiguanide andm-chlorophenylbiguanide, behav-ioral effects (rats), 1440

5-HT4

gastric emptying, SC-49518 (dogs), 240pharmacological analyses, DAU 6285

(rats, guinea pigs), 6545-HT1A

agonist properties, methoxy-chromanderivatives (rats), 863

induction of hypothermia (rats), 1364

tail-flick response and (rats), 955-HT1�, chronic clozapine treatment, cho-

roidplexus (rats), 1262kinin Bi and B2, superior mesenteric an-

tery smooth muscle cells (rabbits),930

N-methyl-D-aspartateantagonist, NPC 17742 (rats, mice, ger-

bils), 256antagonist LY274614, attenuation and

reversal of morphine tolerance (rats),1090

discriminative stimulus, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonohep-

tanoic acid (rats), 845muscarinic

antimuscarinic agents, intestinal motil-ity (dogs), 789

differential effects of alkylating agents,brain cortical membranes (rats), 521

phosphoinositide turnover, tetrahy-droaminoacridine (rats), 463

muscarinic M3, autoradiographic map-ping, brain (rats), 415

neurotensin, desensitization and down-regulation, N1E-1i5 cells (mice), 1

nicotinic, stimulation of rubidium efflux,

brain synaptosomes (mice), 542nicotinic acetylcholine, redox effects, ner-

eistoxin (chicks), 689opioid, neuroanatomical sites, condi-

tioned place preference paradigm(rats), 489

opioiddeltaforskolin and isobutylmethylxanthine,

NG1O8-15 cells,1474single functional subtype, vas deferens

(mice), 831

opioid delta-2, development of morphinedependence (mice), 1141

1508 Index Vol. 264

opioid epsilon, properties, brain (rats,guinea pigs, cows, pigs, chickens), 349

opioid kappaactivation by U-50,488H, release of

substance P from trigeminal nucleusslices (rats), 648

pharmacological study, 14(3-(thioglyco-lamido)-7,8-dihydro-N(cyclopropylmethyl)-normorph in-one (mice), 1021

opioid mu-2 and alpha adrenergic, mor-phine-induced suppression, spleno-cyte natural killer activity, 1179

opioid mu and kappa, agonists, antago-nism of respiratory effects by U-SO,488H (rats), 631

opioid sigma and muscarinic, centralnervous system binding sites, co-caine-induced seizures and lethality,

1333somatostatin, subtypes, anterior pituitary

cell line GH3 (rats), 110thromboxane

antagonist BMS 180,291, binding andfunction in platelets (humans), 1387

glomerulus, lupus nephritis (mice), 584

Refino, C. J., see Thomas G. H., 67Reimann, W., see Jackisch, H., 889Reisine, T., see Raynor, K., 110Reiss, D. H., see Pettibone, D. J., 308Renin, hormonal and cardiovascular effects,

losartan (monkeys), 6Reserpine, pharmacological analyses of

DAU 6285, tunica muscularis mu-

cosae, ileum (rats, guinea pigs), 654Respiration

antagonist of respiratory effects, U-SO,488H, mu opioid receptor agonists(rats), 631

thermal antinociception, clonidine, dex-medetomidine and xylazine (mon-keys), 762

Respiratory depression, apparent pA2 analy-sis, alfentanil and etonitazene,ethylketocyclazocine and Mr2033(monkeys), 145

Retina, neuronal nicotinic acetylcholine re-ceptors, redox effects, nereistoxin(chicks), 689

Reuveny, E., Twombly, D. A. and Nara-hashi, T.: Chlordiazepoxide block oftwo types of calcium channels inneuroblastoma cells, 22

Reynolds, C. J., see Proud, D., 1124Reynolds, J. M., see Mehvar, H., 662Rezazadeh, S. M., see Prather, P. L., 622Rhim, H., Glaum, S. H. and Miller, H. J.:

Selective opioid agonists modulateafferent transmission in the rat nu-cleus tractus solitarius, 795

Ricaurte, G. A., see Scanzello, C. H., 1484Ricci, A., Escaf, S., Vega, J. A. and Amenta,

F.: Autoradiographic localization ofdopamine D1 receptors in the humankidney , 431

Richelson, E., see Di Paola, E. D., 1Hiker, W. K., see Saiyed, M., 1146Ritz, M. C. and George, F. H.: Cocaine-

induced seizures and lethality appearto be associated with distinct centralnervous system binding sites, 1333

Rivet, J.-M., see Bervoets, K., 95Rivet, J.-M., see Millan, M. J., 1364Riviere, P. J. M., Rao, H. K., Pascaud, X.,

Junien, J. L. and Porreca, F.: Effects

of neuropeptide Y, peptide YY andsigma ligands on ion transport inmouse jejunum, 1268

HNA, messengerantisense oligodeoxynucleotide, receptors

with seven transmembrane spanningregions, cerebellar granule cells(rats), 423

chronic intragastric ethanol infusion, ep-isodic ethanol excretion (rats), 938

Ho 11-2933, reversal of doxorubicin resist-ance (rats), 1299

Ho 19-3704, competitive inhibition of phos-pholipase A2, suppressive effect,platelet activation (rabbits), 1460

Ho 43-5054, coronary artery reperfusion andreocclusion, thrombolysis, tissue-

type plasminogen activator (dogs),501

Robertson, G. S., Tham, C.-S., Wilson, C.,Jakubovic, A. and Fibiger, H. C.: Invivo comparisons of the effects ofquinpirole and the putative presyn-aptic dopaminergic agonists B-HT920 and SND 919 on striatal dopa-

mine and acetylcholine release, 1344Rogers, T. J., see Bussiere, J. L., 591Rolipram

antidepressant-like effects, behavior, dif-ferential reinforcement of low re-sponse rate (rats), 1168

isozyme-selective phosphodiesterase in-hibitors, pulmonary antiallergic andbronchodilator effects (guinea pigs),609

Romanelli, L., see Valeri, P., 1028Ronis, M. J. J., Crouch, J., Mercado, C.,

Irby, D., Valentine, C. H., Lumpkin,C. K., Ingelman-Sundberg, M. andBadger, T. M.: Cytochrome P450CYP 2E1 induction during chronicalcohol exposure occurs by a two-stepmechanism associated with blood al-

cohol concentrations in rats, 944Ronis, M. J. J., see Badger, T. M., 438Roper, L. C., see Gonzales, H. A., 282Roux, S. P., Tschopp, T. B., Kuhn, H.,

Steiner, B. and Hadv#{227}ry,P.: Effectsof heparin, aspirin and a syntheticplatelet glycoprotein llb-llla receptorantagonist (Ho 43-5054) on coronaryartery reperfusion and reocclusionafter thrombolysis with tissue-typeplasminogen activator in the dog, 501

Rovero, P., see Patacchini, H., 17Howan, G. A., see Prather, P. L., 622Rubidium, stimulation of efflux, nicotinic

receptor function, brain synapto-somes (mice), 542

Ruiz, P., see Spurney, H. F., 584Hush, C. H., Higgins, S. T., Bickel, W. K.

and Hughes, J. H.: Acute effects oftriazolam and lorazepam on humanlearning, performance and subjectratings, 1218

Hustum, Y. M., see Alaoui-Jamali, M. A.,1299

RX821002, discrimination and pharmaco-logical characterization, I2-imidazo-line sites, brain (humans, rats), 1187

Hyanodine, cholinergic agonist- and K�-in-duced cytosolic-free Ca�� signals, ef-fects of caffeine, adrenal chromaffincells (pigs), 770

S 14671, induction of hypothermia, S-HT1A

receptor-mediated activity (rats),1364

Sabra, H., see Abets, B. C., 1285Sadowska-Krowicka, H., see Miller, M. J.

S., 11Saifeddine, M., see Yang, S.-G., 958Saiyed, M. and Hiker, W. K.: Cholinergic

and anticholinergic drug effects onsurvival during hypoxia: Significantgender differences, 1146

Sakakibara, Y., see Jia, H., 1275Sall#{233}s,J., Wallace, M. A. and Fain, J. N.:

Differential effects of alkylatingagents on the multiple muscarinic re-ceptor subtypes linked to activationof phospholipase C by carbachol inrat brain cortical membranes, 521

Sarcoplasmic reticulum, alterations of cal-cium dynamics, U46619, cardiomy-

ocytes (rats), 336Sastre, M., see Miralles, A., 1187Satoh, S., see Ogasawara, A., 117Sawchuk, H. J., see Wong, S. L., 899SC-49518, gastric emptying of solid and liq-

uid meals, motility, 5-HT4 receptormechanism (dogs), 240

Scanzello, C. H., Hatzidimitriou, G., Mar-tello, A. L., Katz, J. L. and Ricaurte,G. A.: Serotonergic recovery after (±)-3,4-methylenedioxymethamphe-tamine injury: Observations in rats,1484

Scarpace, P. J., see Bender, B. S., 1381Schafer, S. G., see Ernsberger, P., 172Schecter, H. L., see Alaoui-Jamali, M. A.,

1299Schenken, H. S., see King, T. S., 29Schilling, W. P., see Elliott, S. J., 1063Schizophrenia, electrophysiological effects,

diphenylpyrazolidinone cholecysto-

kinin-B and -A antagonists (rats),480

Schluet, W., see Holzer, P., 391Schmitt, M., see Hechler, V., 1406Schmitz, D. A., see Cho, A. K., 1401Schneider, H. H., see Steppuhn, K. G., 1395Schror, K., see Hohlfeld, T., 397Schumacher, W. A., see Ogletree, M. L., 570Schuurkes, J. A. J., see De Ridder, W. J. E.,

79Seiki, M., see Ueki, S., 152Seizure, susceptibility, manipulation of en-

dogenous adenosine, prepiriform cor-tex (rats), 1415

Seizures, cocaine-induced, lethality, centralnervous system binding sites, 1333

Sellers, E. M., see Higgins, G. A., 1440Sensi, S., see Amoroso, S., 515Seppal#{225},T., see Kuoppamki, M., 1262Serotonin

endothelial relaxing 5-HT receptors, jug-ular vein (rats), 709

-induced contraction in coronary artery,ergolines, vascular 5-HT2-receptorheterogeneity (pigs), 193

pharmacological analyses of DAU 6285,tunica muscularis mucosae, ileum(rats, guinea pigs), 654

recovery after 3,4-methylenedioxyme-thamphetamine injury (rats), 1484

tone-dependent responses, different 5-HT receptors, pulmonary vascularbed (cats), 1315

Sex differences, hormonal regulation ofacetohexamide reductase, postnatal

1993 Index 1509

development, liver and kidney (rats),166

Seyed-Mozaffari A., see Jiang, Q., 1021Shahabi, N. A. and Sharp, B. M.: Activation

of protein kinase C rapidly down-regulates naloxone-resistant recep-tors for f3-endorphin on U937 cells,,276

Shahare, M., see Badger, T. M., 438, 938Sharp, B. M., see Shahabi, N. A., 276Sharpe, L. G., see Katz, J. L., 183Sheldon, H., see Hanger, S., 1160Sheng, J., see Domino, E. F., 221Shepard, D. H., see Apseloff G., 1071Shimamoto, H., see Shimamoto, Y., 201Shimamoto, Y., Shimamoto, H., Kwan, C.-

Y. and Daniel, E. E.: Rauwolscineinduces contraction in the dog mes-enteric artery precontracted withKCI and endothelin-1: Mediation via5-hydroxytryptamine1-like receptors,201

Shippenberg, T. S., see Bals-Kubik, H., 489Shirley, J. T., see Chen, J. B., 922Sholar, J. W., see Mello, N. K., 530Shoubo, M., see Sogabe, K., 1040Showell, H. J., see Chen, J. B., 922Sickels, B. D., see Howell, H. E., 609Siford, G., see Chen, H., 1293Signal transduction

angiotensin II, gastric smooth muscle(guinea pigs), 958

biochemical characterization of FK506,

exocytotic function, pancreatic acini(rats), 873

coexistence of histamine H1 and H2 recep-tors, intestinal muscle cells (guinea

pigs), 598Singer, D. H., see Jia, H., 1275Slawsky, M. T., see Castle, N. A., 1450Smith, J. A., Fraser, D. G. and Fedan, J. S.:

Alteration in the modulatory role ofrespiratory epithelium after exposureof guinea pigs to respirable cottondust, 683

Smith, J. E., see Boundy, V. A., 1002Smith, H. B., see Kroboth, P. D., 1047Smolen, T. N., Brewer, J. A. and Weber, W.

W.: Testosterone modulation of N-acetylation in mouse kidney, 854

SND 919, comparisons with BHT 920 andquinpirole, striatal dopamine andacetylcholine release, 1344

Soares-[da]-Silva, P., Fernandes, H. andPestana, M.: Studies on the role ofsodium on the synthesis of dopaminein the rat kidney, 406

Sodiumextracellular, modulation, flecainide’s

cardiac sodium channel blocking ac-tions, 1160

renal nerve stimulation-induced antina-triuresis, suppression by TMB-8(dogs), 117

synthesis of dopamine in kidney (rats),406

Sodium channel blockers, potassium chan-nel blockers and, interaction, papil-lary muscle (guinea pigs), 1056

Sodium channelsblock by lidocaine, single atrial cells (hu-

mans), 1275contractile effects of nucleotides, trachea

(guinea pigs), 210inhibition of Na�-Ca� exchanger, anoxia

and glucopenia-induced aspartate re-lease, hippocampal slices (rats), 515

modulation of flecainide blocking actions,

extracellular sodium, 1160Sofia, R D., see McCabe, R T., 1248Sogabe, K., Nirei, H., Shoubo, M., Nomoto,

A., Ao, S., Notsu, Y. and Ono, T.:Pharmacological profile ofFH139317, a novel, potent endothelinETA receptor antagonist, 1040

Soman, comparison of antidote protection,pyridostigmine, HI-6 and acetylcho-linesterase, 1085

Sommers, S. L., see Bergsbaken, C. L., 1474Sonntag, W. E., see Breese, C. H., 448Sonoda, J., see Nagakawa, J.-I., 496Spasm, drug-induced, cocaine sensitization,

coronary artery contractions (cattle),1132

Species differences, stereoselective metabo-lism of mephenytoin, cytochromeP450 (rats, rabbits, dogs, monkeys,humans), 89

Spinal cordchronic spinal infusion, dexmedetomi-

dine, ST-91 and clonidine, 3275-HT1A receptors, tail-flick response

(rats), 95Splenocytes, natural killer activity, mor-

phine-induced suppression, alpha ad-renergic and mu-2 opioid receptors,1179

Spurney, H. F., Onorato, J. J., Huiz, P.,Pisetsky, D. S. and Coffman, T. M.:Characterization of glomerularthromboxane receptors in murine lu-pus nephritis, 584

ST-91, dexmedetomidine and clonidine,chronic spinal infusion, aipha-2 adre-noceptor subtypes, 327

Steiner, B., see Roux, S. P., 501Stephens, D. N., see Steppuhn, K. G., 1395Steppuhn, K. G., Schneider, H. H., Turski,

L. and Stephens, D. N.: Long-termtreatment with abecarnil does not in-duce diazepam-like dependence inmice, 1395

Stern, L. S., see Apseloff G., 1071Stevenson, J. I., see Kuster, J. E., 1352Stewart, J. L., see Kostka, P., 234Stockton, M. E., see Rasmussen, K., 480Striatum

AF64A lesions, ipsilateral rotations to D2dopamine agonists (mice), 824

central nervous system tissue, neuro-transmitter release, budipine effects(rabbits), 889

Strobach, H., see Hohifeld, T., 397Stroke, embolic, optimized thrombolysis,

tissue-type plasminogen activator(rabbits), 67

Strychnine, -insensitive glycine receptors,anticonvulsant and neuroprotectantaction, felbamate, 1248

Suarez-Hoca, H. and Maixner, W.: Activa-tion of kappa opioid receptors byU50488H and morphine enhancesthe release of substance P from rattrigeminal nucleus slices, 648

Substance Pactivation of kappa opioid receptors, U-

50,488H and morphine, trigeminalnucleus slices (rats), 648

ascending enteric reflex contraction,propagation of excitation, acetylcho-

line and tachykinins (guinea pigs),391

Sulfamates, organic, ocular pharmacology,carbonic anhydrase inhibitory activ-ity (rabbits), 670

Sulfonylureaglyburide and glipizide, alteration, hepatic

insulin metabolism (rats), 1293modulation of low affinity binding sites,

nucleotides and glibenclamide, brain(rats), 701

Sultana, M., see Wild, K. D., 831Sunaga, K., Chuang, D.-M. and Ishitani, H.:

Tetrahydroaminoacridine is neuro-trophic and promotes the expressionof muscarmnic receptor-coupled phos-phoinositide turnover in differentiat-ing cerebellar granule cells, 463

Superoxide dismutase, effect of arachidonicacid on twitch tension, phrenicnerve-diaphragm (rats), 1311

Suramin, inhibitor, calcemic hormone- andgrowth factor-based bone resorption(mice), 579

Suzuki, T., see Fujita, S., 226Swagler, A. H., see Gallo, J. M., 315Sympathetic nervous system, inhibition of

noradrenaline release from stomach,cholinergic M2 muscarinic receptors(rats), 54

Synapse, potentiation of transmission bytrichloroethanol, mediation by GA-BAA receptors, hippocampal neurons,1097

Synaptosomesbrain, nicotinic receptor function, stimu-

lation of rubidium efflux (mice), 542presynaptic cholinergic actions, DuP 996

(rats), 910Syv#{228}lahti,E., see Kuoppamki, M., 1262

Tabakoff, B., see Liljequist, S., 638Tachykinins

acetylcholine and, ascending enteric re-flex contraction, propagation of ex-citation (guinea pigs), 391

neurokinin A derivatives, agonist and an-

tagonist properties, C-terminal ami-dation (guinea pigs, rabbits, ham-sters, rats), 17

peripheral role, initiation of micturitionreflex (rats), 1327

Tagashira, E., see Ueki, S., 152Takano, Y. and Yaksh, T. L.: Chronic spinal

infusion of dexmedetomidine, ST-91and clonidine: Spinal a�pha� adreno-ceptor subtypes and intrinsic activ-ity, 327

Takeda, S., see Homma, S., 105Takemori, A. E., see Miyamoto, Y., 1141Takemori, A. E., see Wild, K. D., 831Takenaka, T., Forster, H. and Epstein, M.:

Characterization of the renal micro-vascular actions of a new dopami-nergic (DA1) agonist, YM435, 1154

Tanaka-Kagawa, T., Naganuma, A. andImura, N.: Tubular secretion andreabsorption of mercury compunds inmouse kidney, 776

Tandospirone, induction of hypothermia, 5-HT1A i�eptormediated activity(rats), 1364

Tani, M., see Echizen, H., 1425Taylor, S., see Bender, B. S., 1381Tertatolol, induction of hypothermia,

1510 Index Vol. 264

5-HT1A receptor-mediated activity

(rats), 1364Testosterone, modulation of N-acetylation,

kidney (mice), 854Testosterone propionate, hormonal regula-

tion of acetohexamide reductase,postnatal development, liver and kid-ney (rats), 166

Tetrahydroaminoacridine, muscarinic re-ceptor-coupled phosphoinositideturnover, differentiating cerebellargranule cells (rats), 463

Tetrahydrocannabinoid, enantiomeric pairsof cannabinoids, discriminative stim-ulus effects, receptor binding (rats,pigeons), 561

#{244}-9-Tetrahydrocannabinol, delayed matchto sample performance, short-termmemory (rats), 294

Tham, C-S., see Robertson, G. S., 1344Thapsigargin, cholinergic agonist- and K�-

induced cytosolic-free Ca� signals,

effects of caffeine, adrenal chromaf-fin cells (pigs), 770

Theophyllineisozyme-selective phosphodiesterase in-

hibitors, pulmonary antiallergic andbronchodilator effects (guinea pigs),609

kinetics of drug action in disease states,adrenalectomy, pain sensitivity(rats), 859

Thibodeaux, H., see Thomas, G. H., 6714fi-(Thioglycolamido)-7,8-dihydro-

N(cyclopropylmethyl)-normorph in-one, pharmacological study (mice),1021

Thioperamide, histamine release and con-traction, influence of epithelium, tra-cheat strips (guinea pigs), 717

Thomas, G. H., Thibodeaux, H., Bennett,W. F., Refino, C. J., Badillo, J. M.,Errett, C. J. and Zivan, J. A.: Opti-mized thrombolysis of cerebral clotswith tissue-type plasminogen activa-tor in a rabbit model of embolicstroke, 67

Thomas, J. M. and Hoffman, B. B.: Bupren-orphine prevents and reverses theexpression of chronic etorphine-in-duced sensitization of adenylyl cy-clam in SK-N-SH human neuro-blastoma cells, 368

Thomas, P., see Badger, T. M., 438

Thrombin, calcemic hormone- and growthfactor-based bone resorption, sura-mm as inhibitor (mice), 579

Thrombolysiscoronary artery reperfusion and reocclu-

sion, heparin/aspirin/Ro 43-5054,tissue-type plasminogen activator(dogs), 501

optimized, cerebral blots, tissue-type plas-minogen activator (rabbits), 67

Thromboxane, glomerular receptors, lupusnephritis (mice), 584

Thromboxane A2angiotensin II and, postischemic renal

vasoconstriction (dogs), 1285

-prostaglandin endoperoxide receptor an-tagonist, pharmacological profile,BMS 180,291 (humans, rats, cattle,mice, pigs, guinea pigs), 570

receptor antagonist BMS 180,291, bind-ing and function, platelets (humans),

1387

Thromboxane A2 analog, U46619, altera-tions of calcium dynamics, cardiom-yocytes (rats), 336

Tiapamil, analog Ho 11-2933, reversal ofdoxorubicin resistance (rats), 1299

Tidwill, H. H., see Caughey, G. H., 676Tiseo, P. J. and Inturrisi, C. E.: Attenuation

and reversal of morphine toleranceby the competitive N-methyl-D-as-partate receptor antagonist,LY274614, 1090

TMB-8, suppression of renal nerve stimu-lation, induced antinatriuresis(dogs), 117

TNP-470, antitumor effects, microspheresand oil solution, VX-2 carcinoma(rabbits), 469

Toews, M. L., Arneson-Rotert, L. J. andLiewer, S. A.: Bicarbonate inducessensitization of cyclic AMP accumu-lation by intact 1321N1 human astro-cytoma cells, 1211

Toguchi, H., see Kamei, S., 469Tolerance, estimation of effect offset rate

constant, acute tolerance to triazo-lam (humans), 1047

Toraason, M., see Hoffmann, P., 336T#{246}rnebrandt, K., see Bodelsson, M., 709Tortella, F. C., see Dosaka-Akita, K., 631Trachea

contractile effects of nucleotides (guineapigs), 210

contractile receptor, 5-HT2 receptor(guinea pigs), 271

histamine release and contraction, phar-macologic modulation, influence onepithelium (guinea pigs), 717

relaxant effects of nucleotides (guineapigs), 217

respiratory epithelium, alteration in mod-ulatory role, exposure to cotton dust(guinea pigs), 683

Tracheal epithelial cells, bradykinin effects,mediation through B2 kinin receptor,inhibition by Hoe 140 (guinea pigs),1124

Trachte, G. J.,: Atrial natriuretic factor at-ters neurotransmission independ-ently of guanylate cyclase-coupled re-ceptors in the rabbit vas deferens,1227

Traynor, T. H., Brown, D. H. and O’GradyS. M.: Effects of inflammatory me-diators on electrolyte transportacross the porcine distal colon epi-thelium, 61

Triazolamacute tolerance, estimation, effect offset

rate constant (humans), 1047discrimination, selectivity and sensitivity,

novel-response procedure (humans),360

lorazepam and, acute effects, learning andperformance (humans), 1218

1,1,1-Trichloroethane, -produced physicaldependence, effects of drugs and va-pors, withdrawal (mice), 726

Trichloroethanol, potentiation of synaptictransmission, mediation by GABAAreceptors, hippocampal neurons,1097

Trigeminal nucleus caudalis, activation ofkappa opioid receptors, U-50,488Hand morphine (rats), 648

Tninitrobenzenesulfonic acid, epidermalgrowth factor, experimental colitis(rats), 984

Trojnar, J., see Lundin, S., 783Tropea, M. M., Gummelt, D., Herzig, M. S.

and Leeb-Lundberg, L. M. F.: Bi andB2 kinin receptors on cultured rabbit

superior mesenteric artery smoothmuscle cells: Receptor-specific stim-ulation of inositol phosphate forma-tion and arachidonic acid release bydes-Arg�-bradykinin and bradykinin,930

Tropisetron, pharmacological analyses ofDAU 6285, tunica muscularis mu-cosae, ileum (rats, guinea pigs), 654

Tryptases, mast cell, reversible inhibitors,bis(5-amidino-2-benzimidazo-

lyl)methane and related amidines(dogs), 676

Tschopp, T. B., see Roux, S. P., 501d-Tubocurarine, histamine release and con-

traction, influence of epithelium, tra-cheat strips (guinea pigs), 717

Tumor necrosis factor-a, protective effectof E3330, galactosamine-inducedhepatitis (rats), 496

Turski, L., see Steppuhn, K. G., 1395Twombly, D. A., see Heuveny, E., 22Tyrosine kinase, distinct signal transduc-

tion pathways, angiotensin II, gastricsmooth muscle (guinea pigs), 958

U46619, alterations of calcium dynamics,cardiomyocytes (rats), 336

U-5O,488Hactivation of kappa opioid receptors, re-

lease of substance P, trigeminal nu-cleus slices (rats), 648

antagonism of respiratory effects, muopioid receptor agonists (rats), 631

U937 cells, down-regulation of naloxone-resistant receptors, protein kinase Cactivation, (3-endorphin, 276

UDP-glucuronosyltransferase

glucuronidating carboxylic acid-contain-ing drugs, complementary DNA don-ing and expression (humans), 475

repression of drug-metabolizing enzymes,interleukin 1(3, arthritis (rats), 1012

Ueki, S., Seiki, M., Yoneta, T., Aita, H.,Chaki, K., Hori, Y., Morita, H., Ta-gashira, E. and Itoh, Z.: Gastropro-kinetic activity of nizatidine, a newH2-receptor antagonist, and its pos-sible mechanism of action in dogs andrats, 152

Umeda, S., see Fujita, S., 226

Une, T., see Oka, M., 158

Uridine triphosphate, contractile effects ofnucleotides, trachea (guinea pigs),210

Uterusantiuterotonic oxytocin analogs, phar-

macokinetic and pharmacologicproperties (rats), 783

nonpregnant myometrium, adenosine-stimulated contraction, lack of cyclo-oxygenase involvement (guinea pigs),1033

orally active nonpeptidyl oxytocin antag-onist (rats),308

Valentine, C. H., see Honis, M. J. J., 944Valeri, P., Morrone, L. A., Homanelli, L.

1993 Index 1511

and Amico, M. C.: Effect of nonste-roidal anti-inflammatory drugs onwithdrawal responses in guinea pigileum after a brief exposure to mor-phine, 1028

van Belle, K., see Wong, S. L., 899Vargaftig, B. B., see Mounier, C., 1460Vargas, H. M., see Cho, A. K., 1401Vascular bed

hindquarters, inhibitory effects of DuP753 and EXP 3174, angiotensin II(cats),1104

pulmonary, tone-dependent responses ofserotonin, different 5-HT receptors(cats),1315

Vasculature, mesenteric, acute effects ofnicotine, tail artery (rats), 1305

Vas deferensaltered neurotransmission, guanytate cy-

clase-coupled receptors, atrial natri-uretic factor (rabbits), 1227

single functional opioid delta receptorsubtype (mice), 831

Vasoactive intestinal peptide, bis(5-ami-dino-2-benzimidazolyl)methane, re-versible inhibitors, mast cell tryp-

tases (dogs), 676Vasoconstriction, postischemic renal, inter-

action, thromboxane A2 and angio-tensin II (dogs), 1285

Vasodilation, induction by extracellularadenosine 3 ‘ ,5 ‘ -cyclic monophos-phate, pharmacological analysis, cor-onary artery (dogs), 1253

Vasodilators, renal microvascular actions ofYM435 (rats), 1154

Vasopressinantiuterotonic oxytocin analogs, phar-

macokinetic and pharmacologicproperties (rats), 783

orally active nonpeptidyl oxytocin antag-onist (rats), 308

Vega, J. A., see Hicci, A., 431Vein

jugular, endothelial relaxing 5-HT recep-tors (rats), 709

neurokinin A derivatives, agonist and an-tagonist properties, C-terminal ami-dation (guinea pigs, rabbits, hamster,rats), 17

Verapamil, energy level and stimulated in-sulin secretion, islets of Langerhans(rats), 35

Verber, D. F., see Pettibone, D. J., 308Vickroy, T. W.: Presynaptic cholinergic ac-

tions by the putative cognitive en-hancing agent DuP 996, 910

Vignon, J., see Koek, W., 746Virina, M. A., see Gullikson, G. W., 240Vogel, J. H., see McCabe, H. T., 1248

Waikar, M. V., Hegde, S. S., Ford, A. P. D.W. and Clarke, D. E.: Pharmacologi-cal analyses of endo-6-methoxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylate hydrochloride (DAU6285) at the 5-hydroxytryptamine4

receptor in the tunica muscularis mu-cosae of rat and ileum of guinea pig:The role of endogenous 5-hydroxy-tryptamine, 654

Walker, M., see Apseloff G., 1071Wallace, M. A., see Sall#{233}s,J., 521Wambolt, H. B., see Lopaschuk, G. D., 135Wang, L., Chiamvimonvat, N. and Duff, H.

J.: Interaction between selected so-

dium and potassium channel blockersin guinea pig papillary muscle, 1056

Wang, S.-X., see Gullikson, G. W., 240

Ward, S. J., see Kuster, J. E., 1352Wassterstrom, J. A., see Jia, H., 1275Wasterlain, C. G., see McCabe, H. T., 1248Watson, E. G., see Kostka, P., 234Watson, J. W., see Chen, J. B., 922Watts, S. W. and Cohen, M. L.: Further

evidence that the guinea pig trachealcontractile serotonergic receptor is a5-hydroxytryptamine 2 receptor: Useof 5-methyltryptamine and dipropyl-5-carboxamidotryptamine , 271

Webb, M. L., Liu, E. C. K., Monshizadegan,H., Hedberg, A., Misra, H. N., Gol-denberg, H. and Harris, D. N.: Bind-ing and function of a potent newthromboxane receptor antagonist,BMS 180,291, in human platelets,

1387Webb, M. L., see Ogletree, M. L., 570Weber, W. W., see Smolen, T. N., 854Weinger, M. B., see Negus, S. S., 739Weiss, B., see Zhou, L.-W., 824Westbrook, S. L., see Gonzales, H. A, 282White, F. J., see Wolf, M. E., 249Wild, K. D., Carlisi, V. J., Mosberg, H. I.,

Bowen, W. D., Portoghese, P. S., Sul-tana, M., Takemori, A. E., Hruby, V.J. and Porreca, F.: Evidence for asingle functional opioid delta recep-

ton subtype in the mouse isolated vasdeferens, 831

Will, J. A., see Buckner, C. K., 717Willetts, J., see Ferkany, J. W., 256Wilson, C., see Robertson, G. S., 1344WIN 55212-2, binding in cerebellum (rats),

1352Winn, M. J., Asante, N. K. and Ku, D. D.:

Vasomotor responses of canine coro-nary arterial rings to NG-monome-

thyl-L-arginine and Nw nitro L-argi-

nine methyl ester, 265Witkin, J. M., see Katz, J. L., 183Woeppel, S. L., see Howell, H. E., 609Wojcik, W. J., see Holopainen, I., 423Wolf, M. E., White, F. J., Nassar, H., Brood-

erson, H. J. and Khansa, M. H.: Dif-ferential development of autorecep-tor subsensitivity and enhanced do-pamine release during amphetaminesensitization, 249

Wolfe, A. D., see Maxwell, D. M., 1085Wong, S. L., van Belle, K. and Sawchuk, H.

J.: Distributional transport kineticsof zidovudine between plasma andbrain extracellular fluid/cerebrospi-

nat fluid in the rabbit: Investigation

of the inhibitory effect of probenecidutilizing microdialysis, 899

Woods, J. H., see Baron, S. P., 918Woods, J. H., see Butelman, E. H., 145, 762Woyden, C. J., see Pettibone, D. J., 308Wu, D. and Cederbaum, A. I.: Induction of

liver cytochrome P45O2E1 by pyra-zole and 4-methylpyrazole in neona-tat rats, 1468

WY 48,723, WY 50,324 and WY 100,324,induction of hypothermia, 5-HT1A re-ceptor-mediated activity (rats), 1364

Xie, Y., Lane, W. V. and Loring, H. H.:Nereistoxin: A naturally occurringtoxin with redox effects on neuronalnicotinic acetylcholine receptors inchick retina, 689

Xu, Y. and Forsberg, E. J.: Effects of caf-feine on cholinergic agonist- and K�-induced cytosolic-free Ca�� signalsand secretion in porcine adrenalchromaffin cells, 770

Xylazine, clonidine nad dexmedetomidine,thermal antinociception (monkeys),

762

Yaksh, T. L., see Takano, Y., 327Yamada, M., see Di Paola, E. D., 1Yamanaka, T., see Nagakawa, J.-I., 496Yamatsu, I., see Nagakawa, J.-I., 496

Yamazoe, Y., see Yasumoni, T., 89Yanachi, Y., see Imamura, Y., 166Yang, D.-C., see Gullikson, G. W., 240Yang, S.-G., Saifeddine, M., Laniyonu, A.

and Hollenberg, M. D.: Distinct sig-nal transduction pathways for angio-tensin-Il in guinea pig gastric smoothmuscle: Differential blockade by in-

domethacin and tyrosine kinase in-

hibitors, 958Yasumoni, T., Chen, L., Nagata, K., Yama-

zoe, Y. and Kato, H.: Species differ-ences in stereoselective metabolismof mephenytoin by cytochrome P450(CYP2C and CYP3A), 89

Yokotani, K. and Osumi, Y.: Cholinergic M2muscarinic receptor-mediated inhi-

bition of endogenous noradrenalinerelease from the isolated vascularityperfused rat stomach, 54

Yoneta, T., see Ueki, S., 152Yoshioka, T., see Kamei, S., 469Youngren, K. D., Daly, D. A. and Moghad-

dam, B.: Distinct actions of endoge-nous excitatory amino acids on theoutflow of dopamine in the nucleus

accumbens, 289

Yuan, L.-X., see Fedan, J. S., 210, 217

Zabrowski, D. L., see Gullikson, G. W., 240Zalospirone, induction of hypothermia, 5-

HT1A receptor-mediated activity

(rats),1364Zhang, G., Franklin, P. H. and Murray, T.

F.: Manipulation of endogenousadenosine in the rat prepiriform cor-tex modulates seizure susceptibility,1415

Zhang, 5.-P., see Zhou, L.-W., 824Zhou, L.-W., Zhang, 5.-P., Connell, T. A.

and Weiss, B.: AF64A lesions ofmouse striatum result in ipsilateralrotations to D2 dopamine agonistsbut contralateral rotations to mus-carinic cholinergic agonists, 824

Zidovudinedistributional transport kinetics, plasma

and brain extracellular fluid/cerebro-spinal fluid (rabbits), 899

kinetics, nimodipine effects (monkeys),315

Zimmerman, S. A., see Lovinger, D. M., 1097Zini, H., see Zini, S., 701Zini, S., Zini, H. and Ben-An, Y.: Nucleo-

tides modulate the low affinity bind-ing sites for [3H] glibenclamide in therat brain, 701

Zivan, J. A., see Thomas, G. H., 67Zubieta, J. K. and Frey, K. A.: Autoradi-

ographic mapping of M3 muscarinicreceptors in the rat brain, 415

Zubrowski, H., see Ferkany, J. W., 256

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University School of Medicine is seeking tenure-

track members at the ASSISTANT PROFESSORLEVEL. Applicants should have a Ph.D. and/orM.D. degree, postdoctoral experience, anddemonstrated excellence in research. He/she

will be expected to develop a funded researchprogram in molecular pharmacology, interact

with other faculty members, and contribute to

teaching medical, dental and graduate stu-dents. Applicants should submit curriculumvitae, a brief statement of proposed research,

and names and addresses of three references

to: Search Committee, Department ofPharmacology, Temple University School ofMedicine, 3420 North Broad Street,Philadelphia, PA 19140. The deadline forapplications is July, 1, 1993. Temple University

is an Equal Opportunity/Affirmative Action

Employer. Applications from women andminorities are encouraged.

Choose

______TEMPLE

NOTICE TO CONTRIBUTORS

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