0031-6997/79/2914-0617$02.00/OPHARMACOLOGICAL REVIEWS

Copyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics

Index

Pharmacological Reviews

Volume 30

1978

Vol. 30, No.4Printed in U.SA

Aaronson, P. See van Breemen et a!., 167Absorption, drug. See Drug absorptionAcetaminophen

-induced hepatotoxicity by phenacetin in the mouse,

inhibition of (table), 466

metabolism, pathways of (fig.), 464

metabolites, and liver necrosis, relationship betweenglutathione levels in liver and cobinding of

(table), 465Acetylcholine

as local hormone, 117cell-cell communication and, 117

determination of, 71

environmental messenger, 116formation of

by coupled synthesis, 74from coenzyme A and choline, 74

growth and, 118

in erythrocytes, 96

in spermatozoa, 99

maturation, development, and, 118

other choline esters and, 68

permeability and, 117placental, effect of drug abuse on intrauterine

growth, 113

roles of, in non-nervous tissues, 116

trophic factors and, 118

Acetyicholine noise, surface of an uninnervated my-

otube (fig.), 421

Acetylcholine power spectra, and synaptic currents,at neonatal and adult rat endplates (fig.),422

Acetylcholine receptor, 71acetylcholinesterase and, accumulation at newly

formed nerve-muscle synapses, 411

brain extract-induced increase in, in cultured my-otubes (fig.), 420

clusters of, 412

on uninnervated myotubes, 413; (fig.), 415distribution of, on an innervated muscle fiber (fig.),

414modification of, 420

synapse formation in vitro, 412Acetylcholine sensitivity, mean channel open time as

function of (fig.), 421Acetylcholinesterase

accumulation of, 423acetylcholine receptors and, accumulation of, at

newly formed nerve-muscle synapses, 411

activities of, in sperm from various segments ofepididymis, 99

curare-treated myotubee stained for (fig.), 425

in erythrocytes, substances that inactivate and theireffects on properties of erythrocyte8 (table),96

in platelets, 96

in sperm fractions, 100

release from platelets, 97Acetylcholinesterase stain and synaptic current decay,

correlation between (fig.), 424Acetyltransferase, choline. See Choline acetyltranafer-

ase

Adaptation and homeostasis, 352Adenine nucleotides, release from platelets, 97

Adenylate cyclase, hormonal modulation of, 405Adipocytes, alpha-adrenoceptors and ion permeability

regulation, 235Adrenergic inhibition and excitation and cardiac mem-

brane currents, 42a-Adrenoceptors and cardiac currents, 44/3-Adrenoceptors and cardiac membrane current sys-

tems, 45Adrenocorticotrophin, estimates of in vivo half-lives

in the rat, dog, sheep, pig, and man (table),260

Age-dependent changesin drug distribution, 447hepatic drug metabolism, 448hepatic microsomal drug-metabolizing system, 452

in hepatobiliary function, 454

noninicrosomal hepatic drug metabolism, 453

renal clearance of drugs, 448Age-related changeS

in drug disposition, 445

intestinal drug absorption, 446Amino acids of glycophorin A (fig.), 375Anaphylaxis with thromboxane A2, prostacyclin, and

prostaglandin endoperoxides, 317

Angiotensins I and II, vasoactive peptides, 253Anodonta cygnea cellensis, components of cholinergic

system in gills of, 79Antiarrhythmic drugs. See under Drugs

Antioxidants, antimutagenic effects of, 549

Antipyrine, genetic factors and variations in elimina-tion rates of (fig.), 559

Arachidonic acidmetabolic pathways of (fig.), 294

metabolism, 295

617

618 INDEX

Arrhythmias, cardiac. See Cardiac arrhythmias

Arrhythmogenesis

altered excitability and, 31

membrane factors in, 24

Ascorbic acid-induced sensitization of human fibroblasts to 4-

nitroquinoline 1-oxide (fig.), 495

mutagemc action and DNA-damaging capacity of

oxidation products of (table), 496

Ataxia telangiectasia, sister chromatid exchange for-

mation in, 526

Bacteria, components of cholinergic systems in, 75

Batzinger, Robert P. See Bueding et al., 547Becker, Bernard. See Newbeme et al., 335

Bennett, Hugh P. J., and Cohn McMartin. Peptide

hormones and their analogues: Distribution,

clearance from the circulation, and inactiva-

tion in vivo, 247

Bioassay of acetylcholine, 71

Bishydroxycoumarin, genetic factors and variations inelimination rates of (fig.), 559

Blohm, Thomas R. Drug-induced lysosomal lipidosis:Biochemical interpretations, 593

Blood cells, cholinergic systems in, 93

Bloom’s syndrome, sister chromatid exchange forma-

tion in, 526

Bolender, Robert P. Morphometric analysis in theassessment of the response of the liver to

drugs, 429

Bousquet, William F. See Newberne et al., 335

Bradykinin, vasoactive peptide, 253Bromobenzene metabolism, pathways of (fig.), 463

5-Bromo-2’-deoxyuridinemethodology for sister chromatid exchange, 501

staining protocols for detecting incorporation of,into metaphase chromosomes (table), 502

techniques, sister chromatid differentiation (fig.),502

Bueding, Ernest, Robert P. Batzinger, Young-NamCha, Paul Talalay, and Christopher J. Moli-neaux. Protection from mutagemc effects of

antischistosomal and other drugs, 547

Calcitonin, 266

arteriovenous differences in radioimmunoassayableconcentrations of, across organs in the dog

(table), 268decay of blood peptide concentrations in vitro and

in vivo, 266estimates of in viva half-lives in preparations in the

rat, dog, pig, and man (table), 267Calcium

role, in receptor regulation of membrane permeabil-ity, 209

sodium-, interactions. See Sodium-calcium interac-tions

Calcium current, agents which modify, 50

Calcium transport and sequestering systems, interre-

lation of, with respect to control of cytoplas-mic ionic calcium (fig.), 201

Calliphora salivary gland, 226Cancer impact of compound, total (table), 353

Carcinogen action

complex patterns of, 496

modulating effect of noncarcinogenic chemicalagents on, 494

CarcinogensDNA and, interactions, 493-DNA interactions, modulating factors, 494hepatic activation of (table), 483risk assessment and acceptable risk, 364

Carcinogenic/mutagenic impact, by chemicals (table),353

Carcinogenesis bioassays, maximum tolerated dose

(MTD), lessons learned from, 362Cardiac arrhythmias

ionic mechanisms in heart muscle in relation togenesis and pharmacological control of, 5

reentry and depressed conduction, 29; (fig.), 30

Cardiac membrane currents

a-adrenoceptors and, 44f1-adrenoceptors and, 45adrenergic inhibition and excitation and, 42; (fig.),

44

Cardiac muscle, acetylcholine action on, 84

Cardiovascular disease, serum dopamine fl-hydroxyl-

888 activity in, 157Cell-cell communication and acetylcholine, 117Cell membrane

hormone receptor interactions at, 393

organization of, development of a model, 394Cell nucleus in toxicological investigations (workshop

summary), 342

Cell surface, implications for toxicology (workshopsummary), 336

Cha, Young-Nam. See Bueding et al., 547Chediak-Higashi syndrome, 589

Chemical agentsnoncarcinogenic

inhibitory action of, on DNA repair, 495

modulating effect of, on carcinogen action, 494Chemical interference with mitochondrial function,

606

Chiorthion effect on metabolism of testosterone byliver microsomes (table), 460

Cholecystokinin, 265Choline acetyltransferases, 70

activities of, in sperm from various segments of

epididymis, 99

biosynthesis of acethycholine, 73

in spermatozoa, 99in sperm fractions, 100

Cholinergic systemcomponents of

in cultured cells and developing cell systems, 90in tissues with nervous and non-nervous compo-

nents, 83

in organisms and tissues without nerves, 75

INDEX

469

in tissues with remote involvement with nervoussystem, 80

in blood cells, 93in developing nerve structures, properties of first

and second phase (table), 92in non-nervous tissues, 65in placenta, 102

in plants, 115in spermatozoa, 98

Cholinesterase, 70assay of, 73

in spermatozoa, 99

Chromatin fiber, 470

folding of, in metaphase chromosomes, evidence forradial loops, 470

organization of, in radial loop model (fig.), 474

Chromosomal assays, mammalian cell models, 542Chromosome

-damaging metabolites, catalytic activity of Cu�

ions on thiol compounds in generating (ta-

ble), 496metaphase

folding of chromatin fiber in, evidence for radialloops, 470

histone-depleted (fig.), 471

surface topology of, electron micrograph (fig.), 473swollen with EDTA, cross section of chromatid of

(fig.), 472

Cilia, acetyicholine role in diary movement, 81

Circadian rhythm, serum dopamine /3-hydroxylase,

150

Clastogens, sister chromatid exchange induction by,

505

Cocaine, relationship between membrane “clamp” po-tential and rise of action potential (fig.), 38

Codeine and morphine, plasma concentrations afteroral aspirin-codeine phosphate combination

(fig.), 462

Copper, catalytic activity of, on thiol compounds ingenerating DNA- and chromosome-damag-ing metabolites (table), 496

Core battery

selection criteria, 544short-term tests (table), 545

Cornea

acetyicholine as sensory mediator, 86

acetyicholine in regulation of water and ion traits-port, 87

Cotten, Marion deV., tribute to, 3Coumarin anticoagulant drugs, pedigree of family in-

dicating incidence of resistance to (fig.), 558C-peptide, 272Cyclophosphamide, sister chromatid exchanges in

mouse liver cells by (fig.), 522

Cysteine

effect on covalent binding of acetaminophen to

mouse liver protein (table), 465effect on mutagemc action and DNA-damaging ca-

pacity of MNNG (table), 495Cytochrome P-450

619

catalytic activity of (table), 461physical properties of (table), 461

Cytoplasm, membrane systems of, implications for

toxicology (workshop summary), 339

DBH. See Dopamine $-hydroxylaseDeoxyribonucleic acid

-carcinogen interactions, modulating factors of, 494damage, assays for, 541

damage, repair, and synthesis, relationship of sisterchromatid exchange to, 524

-damaging metabolites, catalytic activity of Cu��ions on thiol compounds in generating (ta-

ble), 496effectiveness of covalent binding of various standard

substances to (table), 611elution during 5-bromo-2’-deoxyuridine dye-Giemsa

procedure (fig.), 503

fragmentation and repair assays, applications of (ta-ble), 498

fragmentation and repair of mammalian cells, mdi-cater for complex interactions between car-

cinogens and modulating factors, 493

organization levels of, in eucaryotic chromosomes,

repair

inhibitory action of noncarcinogemc chemical

agents on, 495

modulating effect of hyperthermia on, 497; (fig.),497

mechanisms, 493systems responding to alkylation (table), 353

sister chromatid interchange, evidence for, at DNA

level, 528; (fig.), 529synthesis, unscheduled, 543

Diabetes, serum dopamine 16-hydroxylase activity in,159

Diener, Robert M. See Newberne et al., 335Diethyl maleate, effect on covalent binding of acet-

aminophen to mouse liver protein (table), 465Diphenylhydantoin action on cardiac membrane, 40

Dopamine $-hydroxylasebiochemical characteristics, 134

adrenal, 134serum, 135

circadian rhythm effects, 150

enzymatic activity, assay of, 136release of, from an adrenergic varicosity (fig.), 143

serum, 133

activity of, in man and experimental animals (ta-ble), 140

assay procedures for, 136; (fig.), 137, 139

drug and hormone effects on activity of, 150

effects of

growth and development on, 146inheritance on, 147; (fig.), 148

stress on, 151immunoassay of, 141in cardiovascular disease, 157in endocrine disease, 158

Dopamine $-hydroxylase-continued

in familial dysautonomia, 157in human disease, 154in hypertension, 154in manic depression, 158in neuroblastoma, 158in neurological disease, 157in renal disease, 156in schizophrenia, 158in torsion dystonia, 157normal values, 140

regulation of, 145

source and fate of, 143Doxorubicin, ventricular tissue of rat treated with

injections of (fig.) 608Droperidol, cardiac electrophysiological properties of,

38

Drug absorption, intestinal, age-related changes in,

446

Drug abuse, interference with placental acetylcholine,effect on intrauterine growth, 113

Drug and steroid hydroxylation, requirements for (ta-

ble), 460Drug distribution, age-dependent changes in, 447Drug disposition

age-related changes in, 445

in experimental animals, variables affecting (table),560

Drug-induced changes in phospholipid composition oftissues (table), 599

Drug-induced lysosomal lipidosia, biochemical inter-

pretations, 593Drug metabolism. See under Metabolism

Drug-metabolizing enzyme system, hepatic micro-somal, age-dependent changes in, 452

Drug-phospholipid complex formation, 596

Drug response

gene-environment interactions, role of, as determi-

nants of drug response, 560

individual factor in, 555antiarrhythmic

action mechanisms, 33chemical structures (fig.), 35classification of (table), 34

antischistosomal and other, protection from muta-

genie effects of, 547commonly used, pharmacogenetics field expanded

to include, 558coumarin anticoagulant, pedigree of family mdicat-

ing incidence of resistance to (fig.), 558effect on

ciliary movement of Mytilus edulis (table), 78serum dopamine fl-hydroxylase activity, 150

Hodgkin-Huxley theory, application to heart musclein relation to action of, 51

liver response tomodel for assessment of, 430; (fig.), 431, 432, 433morphometric analysis in assessment of, 429

mutagemc activation of, by enteric microorganisms,548

620 INDEX

production of abnormal response in pharmacoge-

netic conditions (table), 556renal clearance of, age-dependent changes, 448toxicology of, workshop on, 335

Electrophysiology, myocardial, 5Endocrine disease, serum dopa.mine f3-hydroxylase ac-

tivity in, 159Endoperoxide analogues, structure of (fig.), 303Endoperoxides, metabolism of, 319

Endorphins, opiate receptor agonists, 251

Enkephalins, opiate receptor agonists, 251

Enteric microorganisms, mutagemc activation of drugs

by, 548Environmental messenger, acetylcholine as, 116

Environment

mutagens and antiniutagens in, 359

mutagens from, source (table), 361Enzymatic catalytic site, distinction from ligand roe-

ognition site, 405

Enzyme, effect of infusion of, on glycogen concentra-

tion and recovery of infused enzyme in liverand muscle in glycogen storage disease Ha

(table), 578Enzyme deficiency diseases, relationship to lysosomal

lipidosis, 593Enzyme system, hepatic microsomal drug-metaboliz-

ing, age-dependent changes in, 452

Enzyme treatment, in five lysosomal disorders, 565Enzymes, inhibition of, in the biosynthetic pathway,

295

Epinephrine, effect of infusion of on glycogen concen-

tration in muscle and liver in glycogen storagedisease II (table), 577

Erythrocytes

acetylcholine in, 96acetylcholinesterase activity in, 93choline acetyltransferase in, 96musearinic receptors in, 96

Estrogen-receptor complexes, 479; (fig.), 480

RNA synthesis and, 485Estrogen-receptor interaction in target cells, 479Eukaryotic chromosomes, DNA organization levels in,

469Eukaryotic microorganisms, point mutation assays,

540

Exocrine glands

calcium and stimulus-permeability coupling mech-

anisms, 214ion movements, role in, 214

mammalian, receptor control ofpermeability in, 225Exocrine pancreas. See under Pancreas

Familial dysautonomia, serum dopamine $-hydroxyl-

ase activity in, 157

Fanconi’s anemia, sister chromatid exchange forma-tion in, 526

Fatty acidsunstable derivatives of, 315

in platelets, 316Fibroblasts, acetylcholine action in, 90Fischbach, Gerald D., Eric Frank, Thomas M. Jessell,

INDEX

Lee L. Rubin, and Stephen M. Schuetze.

Accumulation of acetylcholine receptors and

acetylcholinesterase at newly formed nerve-

muscle synapses, 411

Food, mutagens in (table), 361Food coloring, conversion of, by microflora (fig.), 360

Frank, Eric. See Fischbach et al., 411Frog esophagus, acetylcholine and ciliary movement

in, 81, 82Frog skin, cholinesterases in, 81

Gap junctionshigh resistance, 383

information passed through, 389

in mouse liver (fig.), 384, 385electron micrograph (fig.), 386isolated, high-resistance (fig.), 387

low resistance, 388Gap junction dynamics and intercellular commurnca-

tion, 383

Gas chromatography, acetylcholine, 71Gastrin, 263

estimates of in vivo half-lives in the cat, dog, andman (table), 264

Gastrointestinal epithelia, calcium and stimulus-permeability coupling, 234

Gastrointestinal hormones, 263

Gastrointestinal tract, prostacyclin in, 317Gene conversion, mitotic, assays for mitotic recombi-

nation and, 541

Gene-environment interactions, role, as determinants

of drug response, 560

Gene mutation assays

mammalian cell models, 542

point or, bacterial, 540

Genes directly affecting drug disposition, intraspeciesdifferences in frequency of, 555

Gestation period, placental acetyicholine and trans-

port across placenta as function of, 112, 113

Glucagon, 271

Glucose 6-phosphatase, relative specific activity of,with endoplasmic reticulum (fig.), 434

a-Glucosidase activity in mouse liver after injection of

perfiuorinated particles (fig.), 582

Glutathione levels in liver, relationship with covalent

binding of acetaminophen metabolites andliver necrosis (table), 465

Glutathione depression and hepatic molecular binding,

related to exposure to vinyl chloride (fig.),357

Glycogeneffect of

enzyme infusion on concentration and recoveryof, infused enzyme in liver and muscle of agirl with glycogen storage disease Ha (table),

578

epinephrine infusion on concentration of, in mus-cle and liver in glycogen storage disease II

(table), 577Glycogen degradation, cytoplasmic phosphorylase

pathway of, activated by epinephrine infusion

621

(fig.), 568

Glycogenesis type H, prototype of lysosomal disease,566

Glycogen storage disease

classification of (table), 567II

treatment, 575

haamniotic fluid cell of an 18-week-old fetus with

(fig.), 583

effect of enzyme infusion on glycogen concentra-

tion and recovery of infused enzyme in liver

and muscle of a girl with (table), 578liver biopsy specimen (fig.), 576

after enzyme infusion (fig.), 579

after epinephrine infusion (fig.), 577

after 3 weeks of enzyme infusion (fig.), 578before infusion of enzymes (fig.), 568, 569

liver specimen of 18-week-old fetus (fig.), 571

muscle biopsy specimen (fig.), 570

skin fibroblasts of, that have ingested gold parti-

des (fig.), 580

hlbheart autopsy specimen (fig.), 573, 574

muscle biopsy specimen (fig.), 572muscle biopsy specimen in 11-year-old boy with

no clinical signs of the disease (fig.), 575

Glycophorin A

amino acids of (fig.), 375

lipid layer of intact red cell membrane, 376

multimeric forms, 377

phosphorylated molecules of, 378

Glycophorins, 374

Glycoprotein hormones, 278

anterior pituitary, 276

Golberg, Leon. Toxicology: Has a new era dawned?351

Goodenough, Daniel A. Gap junction dynamics and

intercellular communication, 383

Granuloma pouch assay, 613

Gray, Jack E. See Newberne et al., 335Growth

acetylcholine and, 118

development and, effects on serum dopamine ,8-hy-droxylase, 146

intrauterine, retardation of, relationship to placental

acetylcholine and drugs of abuse, 113Growth control, receptor regulation and, 400

Growth hormone, 276

release inhibiting hormone or somatostatin, 258

Haemostasis, prostacyclin, and thromboxane A1-thrombosis, 313

Halothane metabolism, oxidative and reductive path-ways of, schematic representation (fig.), 358

Hauswirth, Otto, and Bramah N. Singh. Ionic mech-anisms in heart muscle in relation to thegenesis and the pharmacological control ofcardiac arrhythmias, 5

Heart. See aLso entries under Cardiac, Myocardial

Heart muscle

622 INDEX

Immunochemical approaches to receptor studies, 487Inflammation, thromboxane A2, prostacyclin, and

Heart muscle-continued

Hodgkin-Huxley theory application to, in relationto drug action, 51

ionic mechanisms in, in relation to genesis and phar-macological control of cardiac arrhythmiaa,

5

Hemopoietic stem cell, component of cholinergic sys-tem in, 92

Hepatic activation of carcinogens (table), 463

Hepatic drug metabolism. See under Metabolism

Hepatic microsomal drug-metabolizing enzyme sys-tem, age-dependent changes in, 452

Hepatic molecular binding and glutathione depression,

related to exposure to vinyl chloride (fig.),

357Hepatobiliary function, age-dependent changes in, 454Hepatocytes

hypothetical, containing a single spherical nucleus,changes occurring within (fig.), 435

stereological sorting of subpopulations of (fig.), 441

Hepatotoxicity, acetaminophen-induced, inhibition by

phenacetin in the mouse (table), 466Hexachiorophen and two stereoisomers, chemical

structures showing neurotoxicity (fig.), 607Hodgkin-Huxley concept, mechanisms of excitation,

10; (fig.), 11, 12, 14, 15, 17Hodgkin-Huxley model. modification of, 17; (fig.), 18,

19Hodgkin-Huxley theory, application to heart muscle

in relation to drug action, 51Hollenberg, Morley D. Hormone receptor interactions

at the cell membrane, 393

Homeostasisadaptation and, 352; (fig.), 354

vascular, prostacyclin release and role in, 310

Hormone

adenylate cyclase modulation by, 405

bound, intracellular localization of, 479effects on serum dopamine �8-hydroxy1ase activity,

150

hypothalamic, 256

local, acetylcholine as, 117

neurohypophyseal

analogues of, 255oxytocin and vasopressin, 254

pancreas, 271

parathyroid, 269

circulating forms of, 270

half-life in blood in vitro and in vivo, 269role of tissues in clearance and conversion of, 270

peptide

analogues and, distribution, clearance from cu-culation, and inactivation in viva, 247

anterior pituitary, 259assay, characterization and identification of, 249bioassay of, 249

biological experimental methods, 250chromatography, 249

comparison of metabolism of, 279concentrations in blood, role of tissues in decay

of, 264

identification of, 249

isotopically labelled, 249levels

blood, decay of, in vitro and in vivo, 255role of tissues in decay of, 255

low molecular weight, primary structures of (fig.),252

mechanisms of clearance and distribution, 280

metabolism. See under Metabolismpyrolysis products isolated from (fig.), 361radioimmunoassay of, 249vasoactive, 253

protein, of anterior pituitary, 276

receptor modulation by, 400

receptor regulation and tachyphylaxis, 401steroid, interaction of, with the nucleus, 477

Hormone acceptors versus receptors, 398

Hormone action

ligand internalization and, 402

membrane fluidity and mobile receptor paradigm of,395

mobile receptor model of (fig.), 394

predictions based on mathematical analysis of,

395receptor aggregation and, 396

receptor cooperativity and, 404Hormone binding in target tissues, 478; (fig.), 478Hormone receptors

acceptors and, the problem of nonspecific binding,397

interactions at cell membrane, 393

regulation, 398

versus acceptors, 398

Hot spots, nerve-induced, 418; (fig.), 416Hottendorf, F. H. See Newberne et al., 335Hug, George. Pre- and postnatal pathology, enzyme

treatment, and unresolved issues in five ly-sosomal disorders, 565

Human chromosome fragility diseases, sister chroma-tid exchange formation in, 526

Human respiratory epithelium, acetylcholine and cull-sty activity in, 82

Hurler’s disease, 583

cerebral cortex specimen of 19-week-old fetus with(fig.), 588

liver specimen of 19-week-old fetus with (fig.), 587

skin fibroblasts of, that pinocytosed colloidal gold

(fig.), 586

Hycanthone, radioactivity in sperm ejaculated after

injection of (table), 6135-Hydroxytryptamine, release from platelets, 97

Hypertension, serum dopamine fl-hydroxylase activityin, 154

Hyperthermia, modulating effect of, on DNA repair,497; (fig.), 497

Hypothalamic hormones, 256

INDEX 623

prostaglandin endoperoxides in, 317Inheritance, effects of, on serum dopamine $-hydrox-

ylase, 147Insulin, 272

estimates of in vivo half-lives of, in pig, baboon, andman (table), 273

Intercellular communication and gap junction dynam-

ics, 383

Intestine

acetylcholine in, 83

drug absorption in, age-related changes, 446

Intracellular interaction mechanism, 482Ionic mechanisms, in heart muscle in relation to gen-

esis and pharmacological control of cardiacarrhythmias, 5

Jensen, Elwood V. Interaction of steroid hormoneswith the nucleus, 477

Jessell, Thomas M. See Fischbach et al., 411

Lacrimal glands, ion permeability control, 221Latt, Samuel A., Rhona R. Schreck, Kenneth S. Love-

day, and Charles F. Shuler. In vitro and invivo analysis of sister chromatid exchange,

501

Leucocytes, cholinergic system components in, 98Lidocaine action on cardiac membrane, 40

Ligand internalization and hormone action, 402Ligand recognition site, distinction from enzymatic

catalytic site, 405

Lipid matrix, amphipathic, 371

Liver. See also Hepatic

adaptive changes that permit maintenance of lowconcentration of the toxic agent in (rat) (fig.),

355

autopsy specimen after injection with perfluorinatedparticles and colloidal gold (fig.), 581

correlation between content of polychlorinated bi-phenyl and the mitochondrial #{246}-aminolevu-

linic acid synthetase activity (fig.), 356membrane permeability modulation by calcium and

cyclic AMP, 228morphological and biochemical data, relationship,

431response to drugs

model for assessment of, 430; (fig.), 431, 432, 433morphometric analysis in assessment of, 429

Liver cellmouse

sister chromatid exchange in (fig.), 521

sister chromatid exchange induction in, by cyclo-phosphamide (fig.), 522

Liver microsomal drug metabolism (table), 458Liver necrosis, glutathione levels in liver, covalent

binding and, relationships with (table), 465

Liver protein, effect of diethyl maleate or cysteine oncovalent binding of acetaminophen to

(mouse) (table), 465

Loutzenhiser, R. See van Breemen et al., 167

Loveday, Kenneth S. See Latt et al., 501

Luteinizing hormone/follicle-stimulating hormone-re-

leasing hormone or luliberin, 257

e8tlmates of in vivo half-lives in rat, dog, pig, andman (table), 257

Luteinizing hormone-releasing hormone

blood concentrations

decay of, in vitro and in viva, 257role of tissues in decay of, 258

Lymphocytes, cholinergic system components in, 97Lysinoalanine toxicity (fig.), 360

Lysosomal disease

glycogenesis type II, the prototype of, 566in toxicology (workshop summary), 347

Lysosomal disorders, pro- and postnatal pathology,enzyme treatment, and unresolved issues in,565

Lysosomal enzyme activities in “normal” cultured fi-broblasts (table), 579

Lysosomal lipidosis

drug-induced, biochemical interpretations, 593

relationship to enzyme deficiency diseases, 593Lysosomes

function and dysfunction of, 565function of, as intracellular disposal system (fig.),

566

in toxicology (workshop summary), 347membrane stabilization with, 597

Lysosomotropism, 598

Mammalian cells

DNA fragmentation and DNA repair of, indicatorfor complex interactions between carcinogens

and modulating factors, 493microbial and, application to assessment of muta-

genicity, 537models, 542

Manic depression, serum dopamine /3-hydroxylase ac-

tivity in, 158

Marchesi, Vincent T. Functional components of sur-face membranes: Potential targets for phar-

macological manipulation, 371

Maturation and development, acetylcholine and, 118Meiotic cells, sister chromatid differentiation in, 522

a-Melanocyte-stimulating hormone, (melanostatin)

256, 259

Membrane. See also Cardiac, Cell, and Surface mem-brane

Membrane permeability, role of calcium in receptor

regulation of, 209Membrane response to uniform current, 9Membrane systems of cytoplasm, implications for tox-

icology (workshop summary), 339

Metabolic activation procedures, 541Metabolic conjugation, time-scale in discovery of (ta-

ble), 352Metabolism

acetaminophen, pathways of (fig.), 464

arachidonic acid, 295; (fig.), 294bromobenzene, pathways of (fig.), 463

drug

624 INDEX

Metabolism-continued

in liver, age-dependent changes in, 448liver microsomal (table), 458

toxicological implications, 457nonmicrosomal hepatic, age-dependent changes

in, 453

endoperoxides, 319

halothane, oxidative and reductive pathways of,

schematic representation (fig.), 358

peptide hormone

arteriovenous differences in vivo, 250blood and plasma in vitro, 250blood or plasma kinetics in viva, 250clearance processes involved in (table), 283comparison of, 279distribution studies in vivo, 250

isolated perfused organs and tissues, 250

processes involved in, 248prostacydlin, 320

testosterone, by rat liver microsomes, chiorthioneffect on (table), 460

thromboxane A2, 320Metabolites, DNA- and chromosome-damaging cata-

lytic activity ofCu� ions on thiol compounds

in generating (table), 496Metachromatic leucodystrophy (MW), 588

3-Methylcholanthrene, effect on liver microsomal cy-

tochrome P-450 and benzo(a)pyrene hydrox-ylase activity (rat) (fig.), 459

Methylguanidine, nitrosation prevention by sodium

ascorbate (fig.), 494

Microbial cellassays, 537

mammalian and, application to assessment of mu-

tagenicity, 537

Mitochondria, effects ofthickening agents on oxidative

phosphorylation in (rat) (table), 609

Mitochondrial function, chemical interference with,606

Mitomycin C, sister chromatid exchanges in humanperipheral lymphocyte by (fig.), 506

Moncada, S., and J. R. Vane. Pharmacology and en-dogenous roles of prostaglandin endoperox-

ides, thromboxane A2, and prostacyclin, 293Morphine and codeine, plasma concentrations after

oral aspirin-codeine phosphate combination(fig.), 462

Morphometry and the future, 441Mucocutaneous membranes, cholinesterases in, 81Mucopolysaccharidosis type I (MPS I), Hurler’s die-

ease, 583

Mucosulfatidosis

cerebral cortex biopsy specimen in (fig.), 585liver biopsy specimen of (fig.), 584multiple sulfatase deficiency, 588

Multiple sulfatase deficiency. See MucosulfatidosisMuscle. See Cardiac, Heart, Skeletal, and Smooth

muscle.

Musculotendinous junctions, acetylcholinesteraseconcentration at, 80

Mutagenesis, implications for toxicology (workshop

summary), 344

Mutagemc activity, reduction of, by pretreatment with2,(3)tert-butyl-4-hydroxyanisole or coadmin-

istration of erythromycin (table), 550Mutagemc effects, protection from, of antischistoso-

mal and other drugs, 547Mutagenicity

application of microbial and mammalian cells toassessment of, 537

testing procedures (table), 538testing requirements (table), 544

Mutagensantimutagens and, environmental, 359

environmental, sources (table), 361infood(table),361

Mutations, preadaptive, affecting the disposition of

and response to foreign compounds, 555Myocardial electrophysiology, 5

Mytilus edulis

components of cholinergic systems in gill plates of,77

drug effects on ciliary movement of (table), 78

Neoplastic disease, serum dopamine fl-hydroxylase ac-

tivity in, 158Nerve-muscle synapses

acetylcholine receptors and acetylcholinesterase ac-

cumulation at, 411

functionally identified, electron micrograph (fig.),419

Nerve structures, developing, properties of first and

second phases of cholinergic system in (ta-ble), 92

Nerves

hot spot induction, 418; (fig.), 416motor, induction of new receptor clusters, 416organisms and tissues without, components of cho-

linergic systems in, 75Nervous tissues, non-

acetylcholine roles in, 116

cholinergic systems in, 65Neuroblastoma

cholinergic system component in, 92serum dopamine ,8-hydroxylase activity in, 158

Neuroblasts, development of cholinergic system in, 91Neurohypophysial hormone. See under HormoneNeurological disease, serum dopamine /1-hydroxylase

activity in, 157Neuromuscular junctions, adult, acetylcholine recep-

tors and acetylcholinesterase at, 411Neurotoxic activation (fig.), 359

Neurotoxicity of hexachiorophene and two stereoiso-

mers, chemical structures of (fig.), 607

Neutrophils, leukocyte function and receptor activa-tion, dependence upon calcium, 236

Newberne James W., Bernard Becker, William F.

Bousquet, Robert M. Diener, Jack E. Gray,

G. H. Hottendorf, Emil A. Pfitzer, Gregory S.Probst, Virgil B. Robinson, Richard L Steel-

INDEX

man, and Robert J. van Ryzin. Summary of

the workshop on cellular and molecular tox-icology, 335

Non-nervous tissues. See Nervous tissues, non-Nuclear interaction, nature of, 483

Nucleosome, 469

Nucleus, steroid hormone interaction with, 477

Opiate receptor agonists, enkephalins and endorphins,251

Oxidative phosphorylation, effects of thickening

agents on, in rat mitochondria (table), 609

Oxytocin, 254

Pacemaker potential, mechanism of, 20; (fig.), 21

Pancreas

exocrine cells of, changes in surface area (fig.), 437

exocrine, role for calcium in modulating ion perme-

abilities in, 223

hormones of, 271

Parathyroid hormone. See under Hormone

Peptide, C-, 272

Peptide hormone. See under HormonePeptide hormone metabolism. See under MetabolismPermeability and acetylcholine, 117Permeability coupling, stimulus-. See Stimulus-perme-

ability coupling

Permeability, membrane. See Membrane permeabilityPfitzer, Emil A. See Newberne et al., 335Pharmacogenetics

expansion of field to include commonly used drugs

and more subjects, 558pedigree of family indicating incidence of resistance

to coumarin anticoagulant drugs (fig.), 558with putative aberrant enzyme, mode of inheritance,

frequency, and drugs that can elicit the signsand symptoms of the disorder (table), 556

Phenacetin, inhibition ofacetaminophen-induced hep-

atotoxicity by (mouse) (table), 466Phenobarbital

effect on

liver microsomal cytochrome P.450, ethylmor-phine N-demethylase activity, and antipyrine

(rat) (fig.), 459

surface area of the endoplasmic reticulum andoxidative demethylase (fig.), 439, 440

Phospholipid composition of tissues, drug-inducedchanges in (table), 599

Phospholipid-drug complex formation, 596

Physical and chemical agents, homeostatic mecha-nisms of a multicellular organism and its

adaptive responses to (fig.), 354

Pituitary, anterior, protein and glycoprotein hormonesof, 276

Placenta

cholinergic system in, 80

cow, acetyicholine-like activity in, 114human

acetylcholine, 103

and transport of chemicals across placenta as

625

function of gestation, 112, 113

effects on blood vessels, 109receptor in, 109

synthesis in, precursors for, 108uptake by fragments of, 108

biogenic amines and other endogenous sub-stances, effect on perfusion pressure of (ta-ble), 110

choline acetyltransferases in, 103

cholinesterases in, 103drug interference with placental acetylcholine, ef-

fect on intrauterine fetal growth, 113monkey, choline acetyltransferase activity, 113mouse, choline acetyltransferase activity, 115

rabbit, acetylcholine-like substances in, 114rat, choline acetyltransferase activity, 115

species variation in cholinergic systems of, 115Placental lactogen, 277

Plants, cholinergic system in, 115

Plasma metabolism, tissue homogenates or slices, 250Platelet aggregation, prostaglandin endoperoxides and

thromboxane A2 in, 302

Plateletsacetylcholine and acetylcholine receptor in, 97acetylcholinesterase in, 96choline acetyltransferase activity in, 975-hydroxytryptamine, adenine nucleotides and ace-

tylcholinesterase release from, 97unstable derivatives of fatty acids in, 316

Point mutation assayseukaryotic microorganisms, 540

gene or, bacterial, 540mammalian cell models, 542

Polychiorinated biphenyl, liver content of, correlationwith 6-aminolevulinic acid synthetase activ-ity (fig.), 356

Postnatal pathology in five lysosomal disorders, 565Potassium currents, compounds influencing, 47; (fig.),

48

Prenatal pathology in five lysosomal disorders, 565Procainamide, antiarrhythmic and arrhythmogenic

properties of, 39, 40Probst, Gregory S. See Newberne et al., 335Proinsulin, 272

estimates of half-lives of, in the pig, baboon, andman (table), 273

Prolactin, 277

Prostacyclin, 306

metabolism of, 320

prostaglandin endoperoxides, thromboxane A2 and,pharmacology and endogenous roles of, 293

therapeutic potential of, 315thromboxane A2-thrombosis, hemostasis and, 313release and role in vascular homeostasis, 310thromboxane A2, imbalance in other pathological

states, 320synthetase, 296

tissues described in (table), 298Prostaglandin endoperoxides

rabbit aorta contracting substance and, 296

626 INDEX

Prostaglandin endoperoxides-continued

thromboxane A2 and, in platelet aggregation, 302

prostacyclin and, pharmacology and endogenous

roles of, 293Protein hormones of the anterior pituitary, 276Protein

mouse liver, effect of diethyl maleate or cysteine oncovalent binding ofacetaminophen to (table),465

“functional,” isolation and characterization of, 379membrane, properties of, 373

pyrolysis products isolated from (fig.), 361

Protozoa, components of cholinergic systems in, 76Psychiatric disease, serum dopamine /3-hydroxylase

activity in, 158Purkinje fiber, action potential (fig.), 23

Putney, James W., Jr. Stimulus-permeability coupling:

Role of calcium in the receptor regulation ofmembrane permeability, 209

Pyridine nucleotide, reduced form of, electron traits-

port to drug substrate (fig.), 458

Pyrolysis products from proteins, peptides and their

amino acids (fig.), 361

Quinidine, cardiac electrophysiological effects of, 39

Ray, Verne A. Application of microbial and mamma-

lian cells to the assessment of mutagemcity,

537Receptor. See also Acetylcholine, Hormone, Estrogen,

and Salivary glandactivation, 481

adenylate cyclase coupling, 406

studies, immunochemical approaches to, 487translocation, 480

mechanism, evidence for (table), 481Red blood cell

calcium and regulation of membrane permeabilityto K, 211

components of cholinergic system in, 79membrane, lipid bilayer, glycophorin A and, 376

Renal clearance of drugs, age-dependent changes in,448

Renal disease, serum dopamine fl-hydroxylase activity

in, 156Repolarization, underlying mechanisms, 22; (fig.), 23Reproductive system, prostacyclin in, 317Ribonucleic acid synthesis, estrogen-receptor corn-

plexes and, 485Robinson, Virgil B. See Newberne et al., 335Rubin, Lee L. See Fischbach et al., 411

Sadavongvivad, C. See Sastry and Sadavongvivad, 65Salarnanders, acetylcholine and limb regeneration in,

88

Salivary glandscalcium channel, nature of, 218calliphora, ion transport and water movement, con-

trol by membrane receptors, 226other ionic fluxes, 220

receptors; Ca and K flux, 214; (fig.), 216

stimulus-permeability coupling mechanisms, modelfor study, 214

San, R. H. C. See Stich et al., 493

Sarcolemma, cholinesterases in, 80, 81Sarcoplasm, cholinesterases in, 80,81Sastry, B. V. Rama, and C. Sadavongvivad. Choliner-

gic systems in non-nervous tissues, 65Schizophrenia, serum dopamine f3-hydroxylase activ-

ity in, 158

Schmucker, Douglas L. Age-related changes in drugdisposition, 445

Schreck, Rhona R. See Latt et al., 501Secretin, 265Shuetze, Stephen M. See Fischbach et al., 411Shuler, Charles F. See Latt et al., 501Singh, Bramah N. See Hauswirth and Singh, 5Sister chromatid differentiation

5-bromo-2’-deoxyuridine-dye techniques (fig.), 502

induction of, in Chinese hamster ovary chromo-

somes (fig.), 504

in meiotic cells, 522Sister chromatid exchange

agents capable of inducing, strongly positive (table),507

agents exhibiting mixed or weak induction behavior

(table), 516agents found not to induce (table), 519

analysis of, 501basic information, 505biological significance of formation of, 525

5-bromo-2’-deoxyuridine dye methodology for, 501extension of studies of, from in vitro to in vivo

systems, 505

formation of, in human chromosome fragility dis-eases, 526

human lymphocytes (fig.), 504

induction ofby clastogens, 505in human peripheral lymphocyte by mitomycin C

(fig.), 506

in mouse liver cells by cyclophosphamide (fig.),522

induction tests, interpretation of, 523in mouse liver cell (fig.), 521

mechanism of formation of, 528

relationship ofinduction of, to DNA damage, repair,and synthesis, 524

Sister chromatid interchange, evidence for, at the

DNA level, 528; (fig.), 529

Skeletal muscle, components of cholinergic systems in,80

Smooth muscleacetylcholine action in, 83

alimentary tractouabain and zero potassium, inhibition of sodium,

potassium adenosine triphosphatase, 188potassium elevation, effects of, 183

sodium substitution experiments, 175mammalian, sodium-calcium interactions in, 167

mechanisms and coupling factors in membranepermeability, 231

INDEX 627

ureter

Na,K pump blockade, effects of, 199

sodium substitution, effects, 197

uterine

Na,K ATPase inhibition, effects of, 196sodium substitution, 194

vascular

effects of sodium substitution, 170

sodium, potassium, and adenosine triphosphataseinhibition, 173

Sodium-calcium interactions

in mammalian smooth muscle, 167molecular mechanisms, 167; (fig.), 168specific cellular sites for, 170

Sodium current, fast, compounds influencing, 37Sodium gradient and muscle tension, theoretical rela-

tionship between (fig.), 202Somatostatin, 258

Somatotrophin, 276

Sperm

from various segments of epididymis, choline ace-tyltransferase and acetylcholinesterase activ-ities in, 99

human, effect of cholinergic and cholinergic block-ing drugs on motility of, 101

sea urchin, effects of cholinergic and cholinergicblocking agents on motility of sperm from,

100; (table), 101Spermatozoa

cholinergic system in, 79,80,98

sterility and, 102Sperm fractions, choline acetyltransferase and acetyl-

cholinesterase in, 100

Sperm motility, effects of cholinergic and cholinergicblocking agents on, 100

Spider, acetylcholine in silk glands of, 87Spleen, acetylcholine and propionylcholine in, 84

Steelman, Richard L. See Newberne et a!., 335Sterility, spermatozoal cholinergic system and, 102Steroid and drug hydroxylation, requirements for (ta-

ble), 460Stich, H. F., R F. Whiting, L Wei, and R H. C. San.

DNA fragmentation and DNA repair of

mammalian cells as an indicator for the corn-plex interactions between carcinogens and

modulating factors, 493Stimulus-permeability coupling, role of calcium in re-

ceptor regulation of membrane permeability,

209

Stress, effects on serum dopamine /3-hydroxylase ac-

tivity, 151Surface membranes, functional components of, targets

for pharmacological manipulation, 371

Symposium, workshop on cellular and molecular tox-icology, 335

Synaptic current

acetylcholine power spectra and, at neonatal andadult rat endplates (fig.), 422

decay, variation in rate of (fig.), 424

Tachyphylaxis and receptor regulation, 401

Target cells, estrogen-receptor interaction in, 479

Target tissues, hormone binding in, 478; (fig.), 478

Testosterone, chlorthion effect on metabolism of, byrat liver microsomes (table), 460

Tetrodotoxin, influence on fast sodium current, 37Thickening agents, effects of, on oxidative phoapho-

rylation in rat mitochondria (table), 609Thiol compounds, catalytic activity of Cu� ions on,

in generating DNA- and chromosome-dam-aging metabolites (table), 496

Thromboxane synthetase, 296Thromboxane A2, 301

metabolism of, 320prostacydlin and, imbalance in other pathological

states, 320prostaglandin endoperoxides and, in platelet aggre-

gation, 302

prostaglandin endoperoxides, prostacydlin and,

pharmacology and endogenous roles of, 293-thrombosis, prostacydlin, and hemostasis, 313

synthetase, tissues described in (table), 2973H-Thymidine, radioactivity in rabbit sperm after in-

jection of (fig.), 613

Thyroid and parathyroid, calcium regulating hor-

mones of, 266

Thyroid disease, serum doparnine$-hydroxylase activ-ity in, 159

Thyroliberin, 256

Thyrotropin-releasing hormone or thyroliberin, 256

Tissues

nonexcitable, calcium and receptor-mediated con-trol of ion permeability, 233

non-nervous, cholinergic systems in, 65

remote involvement with nervous system, compo-nents of cholinergic systems in, 80

Torsion dystonia, serum dopamine �8-hydrozylase ac-tivity in, 157

Toxic agents

in rat liver, adaptive changes that permit mainte-

nance of low concentration of (fig.), 355time scale in discovery of metabolic conjugation

(table), 352Toxicant, interrelationships between sequence of bio-

chemical changes caused by, and associatedpathological events (fig.), 357

Toxicity effect on homeostasis, 352Toxicological investigations, cell nucleus and related

factors�in (workshop summary), 342Toxicological testing, scientific approaches to, 606

Toxicologyapplication of basic concepts to research in, 605

summary of workshop on, 347basic science in, request for more, 605cellular and molecular

summary of workshop on, 335

workshop on, 335

implications for

membrane systems of cytoplasm (workshop sum-

mary), 339

mutagenesis (workshop summary), 344on the cell surface (workshop summary), 336

�‘�±(“�1 Library

.- � . : � � :OSPITAL

628 INDEX

Toxicology-continued

lysosornal diseases in (workshop summary), 347

lysosomes in (workshop summary), 347

new era, 351

summary of workshop on, 335

pharrnacokinetic and metabolic considerations, 611pharmacological approach to, 610

Trachea, acetylcholine and cilia movement in (rabbit),82

Trophic factors and acetylcholine, 118

van Breemen, C., P. Aaronson, and R. Loutzenhieer.

Sodium-calcium interactions in mammaliansmooth muscle, 167

Vane, J. R. See Moncada and Vane, 293van Ryzin, Robert J. See Newberne et aL, 335

Vasopressin, 254

Vesell, Elliot S. Intraspecies differences in frequency

of genes directly affecting drug disposition:

The individual factor in drug response, 555Vinyl chloride, hepatic macromolecular binding and

glutathione depression related to exposure to

(fig.), 357Voltage clamp versus standard electrophysiological

techniques, 37; (fig.), 37,38Wei, L. See Stich et al., 493Weinshilboum, Richard M. Serum dopamine �-hy-

droxylase, 133

Welch, Richard M. Toxicological implications of drug

metabolism, 457Whiting, R. F. See Stich et al., 493Workshop on cellular and molecular toxicology, 335

Zbinden, Gerhard. Application of basic concepts toresearch in toxicology, 605

Zonula occludens in mouse liver (fig.), 384, 385

629

0031-6997/79/3004-0629$02.O0/OPHARMACOLOGICAL REVIEWSCopyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics

Author Index

Pharmacological Reviews

Volumes 1-30

1949-1978

Vol. 30, No.4Printed in USA.

Abraham, E. P. The cephalosporins, 14, 473Adler, T. K. See Way and Adler, 12, 383

Aggeler, Paul M. See O’Reilly and Aggeler, 22, 35Ahiquist, R. P. The receptors for epinephrine and

norepinephrine, a discussion, 11, 441

Akera, Tai, and Brody, Theodore M. The role of

Na�,K�-ATPase in the inotropic action of digitalis,29, 187

Albert, Adrien, Ionization, pH, and biological activity,4, 136

Allen, David G. See Blinks et al., 28, 1Allen, Julius C. See Schwartz et al., 27, 3Ambache, N. Choline esters as local hormones, 6, 113

, The use and limitations of atropine for phar-

macological studies on autonomic effectors, 7, 467Anderson, Hamilton R., and Hansen, Eder L. The

chemotherapy of amebiasis, 2, 399

Andersson, Bengt, and Larsson, Stig. Physiological

and pharmacological aspects of the control of hun-ger and thirst, 13, 1

Angeletti, Piero U. See Levi-Mont.alcini and Angeletti,18, 619

Archer, J. A. See Gorden et al., 25, 179Ari#{235}ns, E. J., van Rossum, J. M., and Simonis, A. M.

Affinity, intrinsic activity, and drug interactions, 9,218

Armentrout, Steven A. See Beard et al., 21, 213Armstrong, Marvin D., and McMillan, Armand. Stud-

ies on the formation of 3-methoxy-4-hydroxy-D-

mandelic acid, a urinary metabolite of norepineph-

line and epinephrine, 11, 394Ashmore, James. See Mayhew et al., 21, 183Atack, C. V. See Carlsson et al., 24, 371Aviado, Domingo M. The pharmacology of the pul-

monary circulation, 12, 159Axelrod, Julius. The metabolism of catecholamines in

viva and in vitro, 11, 402-, Methylation reactions in the formation and me-

tabolism of catecholamines and other biogenic

amines, 18, 95

, Dopamine-$-hydroxylase: regulation of its syn-thesis and release from nerve terminals, 24, 233

, See Glowinski and Axelrod, 18, 775, See Lemberger et al., 23, 371

Bacq, Z. M. Metabolism of adrenaline, 1, 1-, Summary ofdiscussion and commentary, 18, 313Baer, John E. See Beyer and Baer, 13, 417Baird, Joyce D. See Duncan and Baird, 12,91

Baker, J. B. E. The effects of drugs on the foetus, 12,37

Baliga, B. S. See Wurtman et aL, 24, 411Banks, P., and Blaschko, H. Chromaffin tissue, 18, 453Barnes, J. M., and Denz, F. A. Experimental methods

used in determining chronic toxicity, 6, 191

-, and Stoner, H. B. The toxicology of tin com-

pounds, 11, 211

Batzinger, Robert P. See Bueding et al, 30, 547Beard, N. Shelley, Jr., Armentrout, Steven A., and

Weisberger, Austin S. Inhibition ofmaminalian pro-tein synthesis by antibiotics, 21, 213

Becker, Bernard. See Newberne et al., 30, 335Beecher, Henry K. The measurement of pain, 9, 59Beets, M. G. J. The molecular parameters of olfactory

response, 22, 1Bein, H. J. The pharmacology of Rauwolfia, 8, 435Bell, Christopher. Autonomic nervous control of re-

production: circulatory and other factors. 24, 657Belleau, B. Steric effects in catecholamine interactions

with enzymes and receptors, 18, 131Bennett, Ivan L., Jr., and Cluff, Leighton E. Bacterial

pyrogens, 9, 427Berger, F. M. Spinal cord depressant drugs, 1, 243Bergstrom, Suite, Carbon, Lars A., and Weeks, James

R. The prostaglandins: a family ofbiologically activelipids, 20, 1

Berkowitz, Barry. See Spector et al., 24, 191, See Spector et al., 25, 281

Berliner, David L., and Dougherty, Thomas F. Hepaticand extrahepatic regulation of corticosteroids, 13,

329Berliner, Robert W., and Orloff, Jack. Carbonic an-

hydrase inhibitors, 8, 137

Bertaccini, Giulio. Active polypeptides of nonmam-malian orgin, 28, 127

Bertler, A., Falck, B., Owman, Ch., and Rosengrenn,E. The localization of monoaminergic blood-brainbarrier mechanisms, 18, 369

Bertler, Ake, and Rosengren, Evald. Possible role ofbrain dopamine, 18, 769

Beutler, Ernest. Drug-induced hemolytic anemia, 21,73

Beyer, Karl H. Functional characteristics of renaltransport mechanisms, 2, 227

, and Baer, John E. Physiological basis for theaction of newer diuretic agents, 13, 517

Bickel, M. H. The pharmacology and biochemistry of

N-oxides, 21, 325

630 AUTHOR INDEX, VOLUMES 1-30

Bigelow, G., Griffiths, R., and Liebson, I. Experimental

human drug self-administration: methodology and

application to the study of sedative abuse, 27, 523

Bishop, Charles, and Talbott, John H. Uric acid: itsrole in biological processes and the influence uponit of physiological, pathological, and pharmacologi-cal agents, 5, 231

Bizzi, A. See Garattini and Bizzi, 18,243Bjur, R. See Weiner et al., 24, 203Blaschko, H. Amine oxidase and amine metabolism,

4, 415

-, Metabolism of epinephrine and norepinephrine,6, 23

, The development of current concepts of cate-cholamine formations, 11, 307

, Chairman. First Session, Section I: Enzymology,

18, 39-84; Introductory remarks, 39-, See Banks and Blaschko, 18,453Blinks, John R., and Koch-Weser, J. Physical factors

in the analysis of the actions of drugs on myocardial

contractility, 15, 531

, Prendergast, Franklyn G., and Allen, David G.

Photoproteins as biological calcium indicators,

28, 1

, See Koch-Weser and Blinks, 15,601Blohm, Thomas R Drug-induced lysosomal lipidosis:

biochemical interpretations, 30, 593

Bloom, Floyd E., Wedner, H. James, and Parker,Charles W. The use of antibodies to study cell

structure and metabolism, 25, 343Bobbin, Richard P. See Guth et al., 28, 95Bodansky, Oscar. Methemoglobinemia and methe-

moglobin-producing compounds, 3, 144Bohr, David F. Electrolytes and smooth muscle con-

traction, 16, 85

Bolender, Robert P. Morphometric analysis in theassessment of the response of the liver to drugs, 30,429

Borison, Herbert L., and Wang, S. C. Physiology andpharmacology of vomiting, 5, 193

Boullin, D. J. See Costa et al., 18, 577Bousquet, William F. See Newberne et al., 30, 335

Bowman, Robert L. Fluorescence and its measure-ment, 11, 256

Bowman, W. C., and Nott, M. W. Actions of sympa-thomimetic amines and their antagonists on skeletalmuscle, 21, 27

Boyd, Eldon M. Expectorants and respiratory tractfluid, 6, 521

Boyland, E. Mutagens, 6,345Brady, J. V. See Griffith et aL, 27,357Brand, J. J., and Perry, W. L M. Drugs used in motion

sickness. A critical review of the methods available

for the study of drugs of potential value in itstreatment and of the information which has beenderived by these methods, 18, 895

Braun-Menendez, E. Pharmacology of ream and hy-pertensin, 8, 25

Braunwald, Eugene. See Chidsey and Braunwald, 18,685

, See Higgins et al., 25, 119Brawley, Peter, and Duffield, James C. The pharma-

cology of hallucinogens, 24, 31Brendel, K. See Breeder et al., 21, 105Bresnick, Edward. Report on the discussion of the

Third Session, 25, 315Bressler, R., Corredor, C., and Brendel, K. Hypoglycin

and hypoglycin-like compounds, 21, 105Brestkin, A. P. See Kabachnik et aL, 22, 355

Brink, Frank. The role of calcium ions in neural pro-cesses, 6, 243

Brodie, Bernard B., Davies, J. I., Hynie, S., Krishna,G., and Weiss, B. Interrelationships of catechol-amines with other endocrine systems, 18, 273

-, Spector, Sydney, and Shore, Parkhurst A. Inter-action ofdrugs with norepinephrine in the brain, 11,548

-, See Costa et al., 18, 577Brody, Theodore M. The uncoupling of oxidative

phosphorylation as a mechanism of drug action, 7,335

-, Summary ofdiscussion and commentary, 18, 253

, See Akera and Brody, 29, 187Brownlee, George. The wider aspects of the chemo-

therapy of tuberculosis, 5, 421

Br#{252}cke, F. Dicholinesters ofa,�,-dicarboxylic acids and

related substances, 8, 265Bucher, K. Pathophysiology and pharmacology of

cough, 10, 43

Buchthal, Fritz. The effect of acetylcholine-like sub-stances on sensory receptors, 6, 97

Bueding, Ernest. Summary ofdiscussion and commen-tary, 18, 211

-, Batzinger, Robert P., Cha, Young-Nam, Talalay,Paul, and Molineaux, Christopher J. Protectionfrom mutagenic effects of antischistosomal and

other drugs, 30, 547�, and Swartzwelder, Clyde. Anthelmintics, 9, 329-, See Saz and Bueding, 18, 871Buffoni, F. Histaminase and related amine oxidases,

18, 163

Bunker, John P., Chairman, and Vandam, Leroy D.,

Co-chairman. Effects of anesthesia on metabolismand cellular functions: a workshop held under theCommittee on Anesthesia of the National Academy

of Sciences-National Research Council, 17, 183Burgen, A. S. V. Central and sensory transmission, 6,

95

Burn, J. H. Acetylcholine as a local hormone for ciliarymovement and the heart. 6, 107

-, Chairman. Section V: Adrenergic transmission,

18, 459-540; Introductory remarks, 459Burnstock, G. Evolution of the autonomic innervation

of visceral and cardiovascular systems in verte-

brates, 21, 248, Purinergic nerves, 24, 509

-, and Holinan, Mollie E. Junction potentials atadrenergic synapses, 18, 481

Bush, I. E. Chemical and biological factors in theactivity of adrenocortical steroids, 14, 317

AUTHOR INDEX, VOLUMES 1-30 631

Bushby, S. H. M. The chemotherapy ofleprosy, 10, 1Butcher, R. W. Cyclic 3’,S’-AMP and the lipolytic

effects of hormones on adipose tissue, 18, 237Butler, Thomas C. Theories of general anesthesia, 2,

121Butler, Vincent P., Jr. The immunological assay of

drugs, 29, 103-, Watson, John F., Schmidt, Donald H., Gardner,

Jerry D., Mandel, William J., and Skelton, C. Lynn.

Reversal of the pharmacological and toxic effects of

cardiac glycosides by specific antibodies, 25, 239

Cafruny, Edward J. The site and mechanism of actionof mercurial diuretics, 20, 89

Calabresi, Paul. Report on the discussion ofthe Fourth

Session, 25, 359Campbell, T. Cohn, and Hayes, Johnnie R. Role of

nutrition in the drug-metabolizing enzyme system,26, 171

Canaan, Lars A. Blood and tissue changes induced bynorepinephrine-stimulated mobilization offree fatty

acid, 18, 241

-‘ See Bergstrom et al., 20, 1Carbon, Loren D. The role of catecholamines in cold

adaptation, 18, 291Carlsson, Arvid. Detection and assay of dopamine, 11,

300

-, The occurrence, distribution, and physiological

role of catecholamines in the nervous system, 11,

490

-, Pharmacological depletion of catecholamine

stores, 18, 541

-, Kehr, W., Lindqvist, M., Magnusson, T. and

Atack, C. V. Regulation of monoamine metabolismin the central nervous system, 24, 371

Can, Edward A. Drug allergy, 6, 365

Case, Rosemary. Obituary, 18,6Catania, A. C. Drug effects and concurrent perfor-

mances, 27, 385Cha, Young-Nam. See Bueding et al., 30, 547Chenoweth, Maynard B. Monofluoroacetic acid and

related compounds, 1, 383-, Chelation as a mechanism of pharmacological

action, 8, 57, and McCarty, L. P. On the mechanisms of the

pharmacophoric effect of halogenation, 15, 673Chidsey, Charles A., and Braunwald, Eugene. Sym-

pathetic activity and neurotransmitter depletion in

congestive heart failure, 18, 685China, Herman I., and Smith, Paul K. Motion sick-

ness, 7, 33Christenson, James G. See Dairman et al., 24,266Clark, J. M., and Lambertsen, C. J. Pulmonary oxygen

toxicity: a review, 23, 39Clark, W. G. Studies on inhibition of L-dopa decarboz-

ylase in vitro and in vivo, 11, 330

Clarkson, T. W. See Passow et al., 13, 185Cloutier, G. See Weiner et al., 24, 203

Cluff, Leighton E. See Bennett and Cluff, 9, 427Code, Charles F. The inhibition of gastric secretion: a

review, 3, 59Cohen, Gerald. Techniques to improve the specificity

of the trihydroxyindole procedure, 11, 269Cole, Jonathan 0. See Kierman and Cole, 17, 101

Conney, A. H. Pharmacological implications of micro-somal enzyme induction, 19, 317

Cooper, Theodore. Surgical sympathectomy and ad-renergic function, 18, 611

Con, Carl, Chairman. Carbohydrate Metabolism, See-tion II: Metabolic Effects of Catecholamines, 18,

145-213

, See Helmreich and Cori, 18, 189Corredor, C. See Bressler et aL, 21, 105

Costa, E., Boullin, D. J., Hammer, W., Vogel, W., andBrodie, B. B. Interactions of drugs with adrenergicneurons, 18, 577

-, Green, A. R, Koslow, S. H., LeFevre, H. F.,

Revuelta, A. V., and Wang, C. Dopamine and nor-epinephrmne in noradrenergic axons: a study in vivo

oftheir precursor product relationship by mass frag-

mentography and radiochemistry, 24, 167Crout, J. Richard. Some spectrophotofluorimetric ob-

servations on blood and urine catecholamine assays,11, 296

, Pheochromocytoma, 18,651Curtis, D. R The pharmacology of central and periph-

eral inhibition, 15, 333, and Watkins, J. C. The pharmacology of amino

acids related to gamma-aminobutyric acid, 17, 347

Cuthbert, A. W. Membrane lipids and drug action, 19,

59

Dahlstr#{246}m, Annica. See Hillarp et al., 18, 727Dairman, Wallace, Christenson, James G., and Uden-

friend, Sidney. Changes in tyrosine hydroxylase anddopa decarboxylase induced by pharmacological

agents, 24, 266Dale, Sir Henry H. The beginnings and the prospects

of neurohumoral transmission, 6, 7Dalgaard-Mikkelsen, Sv., and Poulsen, Emil. Toxicol-

ogy of herbicides, 14, 225Daly, M. de Burgh. Acetylcholine and transmission at

chemoreceptors, 6, 79Dam, Henrik. Influence of antioxidants and redox

substances on signs of vitamin E deficiency, 9, 1Daniels-Severs, Anne E. See Severs and Daniels-Sev-

era, 25, 415

Danowski, T. S., and Elkinton, J. R. Exchanges of

potassium related to organs and systems, 3, 42Darken, Marjorie A. Puromycin inhibition of protein

synthesis, 16, 223Davies, B. N., and Withrington, P. G. The actions of

drugs on the smooth muscle of the capsule andblood vessels of the spleen, 25, 373

Davies, J. I. See Brodie et al., 18, 273Davis, Jean P. See Toman and Davis, 1, 425Dawes, G. S. Experimental cardiac arrhythmias and

quinidine-like drugs, 4,43de Champlain, Jacques. Report on the discussion of

the Fourth Session, 24, 431

632 AUTHOR INDEX, VOLUMES 1-30

DeLange, Robert J. See Krebs et al., 18, 163Delmonte, Lilian, and Jukes, Thomas H. Folic acid

antagonists in cancer chemotherapy, 14, 91De Matteis, F. Disturbances of liver porphyrin metab-

olism caused by drugs, 19, 523Dengler, Hans J. See Titus and Dengler, 18, 525

De Robertis, Eduardo. Adrenergic endings and vesi-des isolated from brain, 18, 413

de Wied, D. Chiorpromazine and endocrine function,19, 251

Dews, P. B. Introduction: Schedule-induced polydipsiaand oral intake of drugs, 27, 447

, Are the techniques and results of studies of self-administration of drugs useful in other areas of

psychobiology, 27, 545Diener, Robert M. See Newberne et al., 30, 335

Doak, George 0. See Eagle and Doak, 3, 107Domino, Edward F., Hardman, Harold F., and Seevers,

Maurice H. Central nervous system actions of somesynthetic tetrahydrocannabinol derivatives, 23, 317

, See Hardman et al., 23, 295Dontas, A. S. See Hoobler and Dontas, 5, 135Dorfman, Albert. Metabolism of the mucopolysaccha-

rides of connective tissue, 7, 1

Dornhorst, A. C. Adrenergic blockade in cardiovascu-lar disease, 18, 701

Dougherty, Thomas F. See Berliner and Dougherty,

13, 329

Douglas, W. W. Is there chemical transmission at

chemoreceptors?, 6, 81

, The mechanism of release of catecholaminesfrom the adrenal medulla, 18, 471

Downs, D. A., and Woods, J. H. Naloxone as a negativereinforcer in rhesus monkeys: effects of dose, sched-

ule, and narcotic regimen, 27, 397Drill, Victor A. Hepatotoxic agents: mechanism of

action and dietary interrelationship, 4, 1Duncan, Leslie J. P., and Baird, Joyce D. Compounds

administered orally in the treatment of diabetesmellitus, 12, 91

Duffield, James C. See Brawley and Duffield 24, 31Dustin, P., Jr. New aspects of the pharmacology of

antimitotic agents, 15, 449

Dyrenfurth, I. See Vande Wiele and Dyrenfurth, 25,

189

Eagle, Harry, and Doak, George 0. The biologicalactivity of arsenosobenzenes in relation to their

structure, 3, 107Edvinsson, Lars, and MacKenzie, Eric T. Amine mech-

anisms in the cerebral circulation, 28, 275

Ehrenpreis, Seymour, Fleisch, Jerome H., and Mittag,

Thomas W. Approaches to the molecular nature ofpharmacological receptors, 21, 131

Eldjarn, Lorentz. See Pihi and Eldjarn, 10, 437Elion, G. B. See Hitchings and Elion, 15, 365

Elkinton, J. R. See Danowski and Elkinton, 3, 42Ellis, Sydney. The metabolic effects of epinephrine

and related amines, 8, 485

, Relation of biochemical effects of epinephrine to

its muscular effects, 11, 469Elmadjian, Fred. Excretion and metabolism of epi-

nephrmne, 11, 409

Emmelin, N. Supersensitivity following “pharmaco-

logical denervation,” 13, 17Engbaeck, Lisa. The pharmacological actions of mag-

nesium ions with particular reference to the neuro-

muscular and the cardiovascular system, 4, 396

Er#{228}nk#{246},Olavi. Demonstration of catecholamines andcholinesterases in the same section, 18, 353

Erlanger, Bernard F. Principles and methods for the

preparation of drug protein conjugates for immu-nological studies, 25, 271

Erspamer, V. Pharmacology of indoleakylamines, 6,

425

Exton, J. H., and Park, C. H. The stimulation of

gluconeogenesis from lactate by epinephrine, glu-

cagon, and cyclic 3’,5’-adenylate in the perfused ratliver, 18, 181

Fain, John N. Biochemical aspects of drug and hor-

mone action on adipose tissue, 25, 67Fairhurst, Alan S. See Jenden and Fairhurst, 21, 1Falck, B. See Bertler et al., 18, 369

Falk, J. L., and Samson, H. H. Schedule-induced phys-ical dependence on ethanol, 27, 449

F#{228}nge,H. Pharmacology ofpoikilothermic vertebratesand invertebrates, 14, 281

Fastier, F. N. Structure-activity relationships of aim-dine derivatives, 14, 37

Featherstone, H. M., and Muehlbaecher, C. A. The

current role of inert gases in the search for anesthe-

sia mechanisms, 15, 97Feldberg, W. S. Central and sensory transmission, 6,

85Feldberg, W., Chairman. Section VIII: Adrenergic

Mechanisms in the Nervous System, 18, 713-803Introductory remarks, 713

Fischbach, Gerald D., Frank, Eric, Jessell, ThomasM., Rubin, Lee L., and Schuetze, Stephen M. Ac-cumulation of acetyicholine receptors and acetyl-

cholinesterase at newly formed nerve-muscle syn-

apses, 30, 411Fisher, James W. Erythropoietin: pharmacology, bio-

genesis, and control of production, 24, 459Fleisch, Jerome, H. See Ehrenpreis et al., 21, 131Flesch, P. Inhibition of keratinizing structures by sys-

temic drugs, 15, 653Flower, Roderick J. Drugs which inhibit prostaglandin

biosynthesis, 26, 33

Flynn, Edward J. See Spector et al., 25, 281Forney, Robert B. Toxicology of marihuana, 23, 279

Fox, B. N., and Fox, Margaret. Biochemical aspects ofthe actions of drugs on spermatogenesis, 19, 21

Fox, Margaret. See Fox, B. N., and Fox, Margaret, 19,21

Frank, Eric. See Fischbach et al., 30, 411Franklin, Edward C. Report on the discussion of the

Second Session, 25, 269

Fraser, H. F. See Isbell and Fraser, 2, 355

AUTHOR INDEX, VOLUMES 1-30 633

Freedman, Daniel X. See Giarman and Freedman, 17,

1

French, J. E. See Robinson and French, 12, 241Freyburger, Walter A. See Moe and Freyburger, 2, 61Friedenwald, Jonas S. Histochemistry-a review, 7,83

Friedman, Stanley. See Kaufman and Friedman, 17,71

Furchgott, Robert F. The pharmacology of vascularsmooth muscle, 7, 183

-, The receptors for epinephrine and norepineph-

rime (adrenergic receptors), 11, 429

-, Summary ofdiscussion and commentary, 18,641Fuxe, Kjell. See Goldstein et a!., 24, 293

-, See Hillarp et al., 18, 727

Gaddum, Sir John H. Bioassays and mathematics, 5,87

-, Theories of drug antagonism, 9, 211-, Bioassay procedures, 11, 241

, Obituary, 18, 5Gale, E. F. Mechanisms of antibiotic action, 15, 481Garattini, S., and Bizzi, A. Effect of drugs on mobili-

zation of free fatty acid, 18, 243

Gardner, Jerry D. See Butler et al., 25, 239Gavin, J. R., III. See Gorden et al., 25, 179Gerard, R. W. Closing remarks to symposium on neu-

rohumoral transmission, 6, 123Germuth, Frederick G., Jr. The role of adrenocortical

steroids in infection, immunity, and hypersensitiv-ity, 8, 1

Giarman, Nicholas J., and Freedman, Daniel X. Bio-chemical aspects of the actions of psychotomimetic

drugs, 17, 1

Gibbins, R. J� See Kalant et al., 23, 135

Gill, C. A. See Holz and Gill, 27, 437

Gillespie, J. S. Summary of discussion and commen-

tary, 18, 537Gilman, Alfred, and Koelle, G. B. Anticholinesterase

drugs, 1, 166

Ginsborg, B. L. Ion movements in junctional traits-mission, 19, 289

Gitlow, S. E. Summary ofdiscussion and commentary,18, 707

Glaval, E. See Nikodijevi#{233} et a!., 18, 705Glick, Seymour M. Report on the discussion of the

First Session, 25, 209Glowmski, J., and Axelrod, J. Effects of drugs on the

disposition of H3-norepinephrmne in the rat brain,

18, 775

Glowinski, Jacques, and Baldessarini, Ross J. Metab-

olism of norepinephrine in the central nervous sys-

tern, 18, 1201

Glynn, I. M. The action of cardiac glycosides on ionmovements, 16, 381

Godovikov, N. N. See Kabachnik et al., 22, 355

Goffart, M. The action of l-noradrenaline and adre-nochrome on unfatigued mammalian muscle, 6, 33

Golberg, Leon. Keynote Address. Toxicology: Has anew era dawned?, 30, 351

Goldberg, Leon I. Cardiovascular and renal actions of

dopamine: potential clinical applications, 24, 1

Goldberg, S. R. Stimuli associated with drug injectionsas events that control behavior, 27, 325

, and Kelleher, R. T. Introduction: schedules oftermination of drug injections, 27, 395

, See Kelleher and Goldberg, 27, 291, 341

Goldfien, Alan. Effects of glucose deprivation on the

sympathetic outflow to the adrenal medulla and

adipose tissue, 18, 303

Goldstein, Avram. Interactions of drugs and plasma

proteins, 1, 102

Goldstein, M. Inhibition of norepinephrine biosyn-thesis at the dopamine-$-hydroxylation stage, 18,

77, Fuxe, K., and H#{246}kfelt, T. Characterization and

tissue localization ofcatecholamine synthesizing en-

zymes, 24, 293

Goodall, McC. Metabolic products of adrenaline andnoradrenaline in human urine, 11, 416

Goodenough, Daniel A. Gap junction dynamics andintercellular communication, 30, 383

Gorden, P., Gavin, J. R., ifi, Kahn, C. R., Archer, J.A., Lesniak, M., Hendricks, C., Neville, D. M., Jr.,and Roth, J. Application of radioreceptor assay to

circulating insulin, growth hormone, and to theirtissue receptors in animals and man, 25, 179

Gorkin, V. Z. Monoamine oxidases, 18, 115Goz, Barry. The effects of incorporation of 5-haloge-

nated deoxyuridines into the DNA of eukaryotic

cells, 29, 249

Graessle, Otto E. See Molitor and Graessle, 2, 1Grant, W. Morton. Physiological and pharmacological

influences upon intraocular pressure, 7, 143Gray, Jack E. See Newberne et al., 30, 335

Green, A. R. See Costa et al., 24, 167Griffith, R. R., Wurster, R. M., and Brady, J. V.

Discrete-trial choice procedure: effects of naloxoneand methadone on choice between food and heroin,27, 357

Griffiths, R. See Bigelow et al., 27, 523Grub, Mary A. Electron microscopy of sympathetic

tissues, 18, 387Guldberg, Hans C., and Marsden, Charles A. Catechol-

0-methyl transferase. Pharmacological aspects and

physiological role, 27, 135

Gunnison, Janet B. See Jawetz and Gunnison, 5, 175Guth, Paul S., Norris, Charles H., and Bobbin, Richard

P. The pharmacology of transmission in the periph-

eral auditory system, 28, 95

Gyermek, Laszlo. 5-Hydroxytryptamine antagonists,

13, 399

Haag, H. B. See Silvette et al., 14, 137Haber, Edgar, Chairman. Cardiovascular Applica-

tions, The role of antibodies and physiological re-

ceptors in cardiovascular diagnosis, therapy, andresearch, 25, 215

-, See Smith, T. W., and Haber, 25, 219Haddy, Francis J. See Visscher et aL, 8, 389

Hagen, P. The storage and release of catecholamines,

634 AUTHOR INDEX, VOLUMES 1-30

11, 361

Haggendal, Jan. Newer developments in catechol-

amine assay, 18, 325

Hahn, F. Analeptics, 12, 447

Hajdu, Stephen, and Leonard, Edward. The cellularbasis of cardiac glycoside action, 11, 173

Hammer, W. See Costa et al., 18, 577Hansen, Eder L. See Anderson and Hansen, 2, 399Hardman, Harold F., Domino, Edward F., and Seevers,

Maurice H. General pharmacological actions of

some synthetic tetrahydrocannabinol derivatives,23, 295

-, See Domino et al., 23, 317Hartman, Boyd K., and Udenfriend, Sidney. The ap-

plication of immunological techniques to the studyof enzymes regulating catecholamine synthesis and

degradation, 24, 311Harris, Louis S. General and behavioral pharmacol-

ogy, 23, 285

Hasselbach, Wilhelm, and Weber, Annemarie. Models

for the study of the contraction of muscle and of cell

protoplasm, 7, 97Haugaard, Niels, and Hess, Marilyn E. Actions of

autonomic drugs on phosphorylase activity andfunction, 17, 27

-, and Hess, Marilyn E. The influence of catechol-amines on heart function and phosphorylase activ-

ity, 18, 197

-, Kukovetz, Walther R., and Hess, Marilyn E. The

effect ofsympathomimetic amines on phosphorylaseactivity of the isolated rat heart, 11, 466

Hawking, Frank. The chemotherapy of filarial infec-

tions, 7, 279Hawkins, Rosemary D. The metabolism of ethanol

and its metabolic effects, 24, 67Hayaishi, Osamu. Enzymic studies on the mechanism

of double hydroxylation, 18, 71Hayes, Johnnie R. See Campbell and Hayes, 26, 171

Hebb, Catherine 0. Acetylcholine metabolism of ner-vous tissue, 6, 39

Heinle, Robert W. See Welch and Heinle, 3, 345Hellon, R. F. Monoamines, pyrogens, and cations:

their action on central control of body temperature,

26, 289

Helmreich, Ernst, and Cori, Carl F. The activation ofglycolysis in frog sartorius muscle by epinephrine,18, 189

Hendricks, C. See Gorden et al., 25, 179

Hertz, Leif. Drug-induced alterations of ion distribu-tion at the cellular level of the central nervous

system, 29, 35Hess, Marilyn E. See Haug#{225}ard and Hess, 17,27

-‘ See Haugaard and Hess, 18, 197, See Haugaard et al., 11, 466

Heymans, C. Action of drugs on carotid body andsinus, 7, 119

Higgins, Charles B., Vatner, Stephen F., and Braun-wald, Eugene. Parasympathetic control ofthe heart,

25, 119

Hillarp, Nils-Ake. Obituary, 18, 5

-, Fuxe, Kjell, and Dahlstrdm, Annica. Demonstra-

tion and mapping of central neurons containing

dopamine, noradrenaline, and 5-hydroxytryptamineand their reactions to psychopharmaca, 18, 727

Himms-Hagen, Jean. Sympathetic regulation of me-

tabolism, 19, 367

Hitchings, G. H., and Elion, G. B. Chemical suppres-sion of the immune response, 15, 365

Hoff, E. C. See Silvette et al., 14, 137Hoffmeister, F., and Wuttke, W. Psychotropic drugs

as negative reinforcers, 27, 419

H#{246}kfelt, T. See Goldstein et al., 24, 293Hollenberg, Morley D. Hormone receptor interactions

at the cell membrane, 30, 393Hollister, Leo E. Actions of various marihuana deriv-

atives in man, 23, 349

Holman, Mollie E. See Burnstock and Holman, 18,481

Holmstedt, Ba. The action of anticholinesterases on

spinal reflexes following intraarterial injection, 6,49

, Pharmacology of organophosphorus cholinester-

ass inhibitors, 11, 567Holtz, Peter. Role of L-dopa decarboxylase in the

biosynthesis of catecholamines in nervous tissue andthe adrenal medulla, 11, 317

, Chairman. Second Session, Section I: Enzymol-ogy, 18, 85-144; Introductory remarks, 85

-, and Palm, Dieter. Pharmacological aspects of

vitamin B�, 16, 113

Holz, W. C., and Gill, C. A. Drug injections as negativereinforcers, 27, 437

Hoobler, S. W., and Dontas, A. S. Drug treatment of

hypertension, 5, 135Hornykiewicz, Oleh. Dopamine (3-hydroxytyramine)

and brain function, 18, 925Horowicz, Paul. The effects of anions on excitable

cells, 16, 193

Hottendorf, G. H. See Newberne et al., 30, 335

Hug, George. Pro- and postnatal pathology, enzymetreatment, and unresolved issues in five lysosomaldisorders, 30, 565

Hull, R See Hurst and Hull, 8,199Hunt, Carlton C., and Kuffler, Stephen W. Pharma-

cology of the neuromuscular junction, 2, 96Hunter, F. Edmund, Jr., and Lowry, Oliver H. The

effects of drugs on enzyme systems, 8, 89Hurst, E. Weston, and Hull, R. The chemotherapy of

virus diseases, with brief consideration of the influ-

ence of dietary, hormonal, and other factors in virusinfection, 8, 199

Hynie, S. See Brodie et al., 18, 273

Iglauer, C., Liewellyn, M. E., and Woods, J. H. Currentschedules of cocaine injection in rhesus monkeys:

dose variation under independent and non-indepen-dent variable-interval procedures, 27, 367

Ingram, G. I. C. Anticoagulant therapy, 13, 279Isbell, Harris, Chairman. Marihuana and Its Surro-

gates, Session II, 23, 337-380Clinical pharmacology of marihuana, 337

AUTHOR INDEX, VOLUMES 1-30 635

-, and Fraser, H. F. Addiction to analgesics andbarbiturates, 2, 355

Jackson, H. Antifertility substances, 11, 135Jacobowitz, David W. See Kostrzewa and Jacobowitz,

26, 199

Jacobsen, Erik. The metabolism of ethyl alcohol, 4,107

Jawetz, Ernest, and Gunnison, Janet B. Antibioticsynergism and antagonism: an assessment of theproblem, 5, 175

Jenden, Donald J., and Fairhurst, Alan S. The phar-macology of ryanodine, 21, 1

Jensen, Elwood V. Interaction of steroid hormoneswith the nucleus, 30, 477

Jessell, Thomas M. See Fischbach et al., 30, 411Johanson, C. E. Pharmacological and environmental

variables affecting drug preference in rhesus mon-

keys, 27, 343

Johanseon, B#{246}rje.See Meliander and Johansson, 20,117

Johns, Anthony. See Paton et al., 29, 67Jones, Reese T. Marihuana-induced “high”: influence

of expectation, setting, and previous drug experi-ence, 23, 359

Jukes, Thomas H., and Williams, William L. Nutri-tional effects of antibiotics, 5,381

-‘ See Delmonte and Jukes, 14, 91

Kabachnik, M. I., Brestkin, A. P., Godovikov, N. N.,Michelson, M. J., Rozengart, E. V., and Rozengart,

V. I. Hydrophobic areas on the active surface ofcholinesterases, 22, 355

Kahn, C. R. See Gorden et al., 25, 179Kalant, H., LeBlanc, A. E., and Gibbins, R J. Toler-

ance to, and dependence on some non-opiate psy-chotropic drugs, 23, 135

Kao, C. Y. Tetrodotoxin, saxitoxin, and their signifi-

cance in the study of excitation phenomena, 18,997Kappas, A., and Palmer, R. H. Selected aspects of

steroid pharmacology, 15, 123Karlson, Peter. See Sekeris and Karlson, 18, 89

K#{227}ser,Hans. Catecholamine-producing neural tumorsother than pheochromocytoma, 18, 659

Kaufman, Seymour. Coenzymes and hydroxylases:ascorbate and dopamine-fl-hydroxylase; tetrahy-dropteridines and phenylalanine and tyrosine hy-droxylases, 18, 61

-, and Friedman, Stanley. Dopamine-/1-hydroxyl-ass, 17, 71

Kehr, W. See Carlsson et al., 24, 371Kelleher, R. T. Characteristics of behavior controlled

by scheduled injections of drugs, 27,307

-‘ and Goldberg, S. R. General introduction: controlof drug-taking behavior by schedules of reinforce-

ment, 27, 291

-‘ and Goldberg, S. R. Introduction: Complexschedules of drug injection, 27, 341

-, See Goldberg and Kelleher, 27, 395Kemp, Robert G. See Krebs et al., 18, 163

Kety, Seymour S. The theory and applications of the

exchange of inert gas at the lungs and tissues, 3, 1

-, Central actions of catecholamines, a discussion,11, 565

-, Catecholamines in neuropsychiatric states, 18,787

-, Chairman. First Session, Increased Synthesis ofCatecholamines without Changes in Enzyme Levels,24, 167-224

Khromov-Borisov, N. V., and Michelson, M. J. Themutual disposition of cholinoreceptors of locomotor

muscles, and the changes in their disposition in the

course of evolution, 18, 1051

Kiese, Manfred. The biochemical production of fern-hemoglobin-forming derivatives from aromatic

amines, and mechanisms of ferrihemoglobin forms-tion, 18, 1091

Killam, Eva King. Drug action on the brain-stemreticular formation, 14, 175

Kimura, Kazuo K. See Randall and Kimura, 7, 365Kiplinger, Glenn F., and Manno, Joseph E. Dose-re-

spouse relationships to cannabis in human subjects,23, 339

Kirshner, Norman. Biosynthesis of adrenaline andnoradrenaline, 11, 350

-, Summary of discussion and commentary, 18, 83-, and Viveros, 0. H. The secretory cycle in the

adrenal medulla, 24, 385Kizer, John S., Youngbbood, William W., and Nemer-

off, Charles B. Neurotoxic amino acids and struc-turally related analogs, 29, 301

Klaus, Wolfgang. See Lee and Klaus, 23, 193Klerman, Gerald L, and Cole, Jonathan 0. Clinical

pharmacology of imipramine and related antide-

pressant compounds, 17, 101Koch-Weser, J., and Blinks, J. R. The influence of the

interval between beats on myocardial contractility,

15, 601

, See Blinks and Koch-Weser, 15,531Koelle, George B. The localization of specific cholin-

esterase in the retina, 6, 47-, Possible mechanisms for the termination of the

physiological actions of cateeholamines, 11, 381-, Summary of discussion and commentary, 18,359

-, See Gilman and Koelle, 1,166Kopin, Irwin J. Storage and metabolism of catechol-

amines: the role of monoamine oxidase, 16, 179-, Biochemical aspects ofrelease of norepinephrine

and other amines from sympathetic nerve endings,18, 513

-, and Silberstein, Stephen D. Axons of sympa-thetic neurons: transport of enzymes in viva andproperties of axonal sprouts in vitro, 24, 245

-‘ See Lemberger et al., 23, 371Koslow, S. H. See Costa et al., 24, 167Kosterlitz, H. W., and Lees, G. M. Pharmacological

analysis of intrinsic intestinal reflexes, 16,301Kostrzewa, Richard M., and Jacobowitz, David W.

Pharmacological actions of6-hydroxydopamine, 26,199

636 AUTHOR INDEX, VOLUMES 1-30

Krasnegor, N. A. Introduction: behavioral factors in

human drug abuse, 27,499Krebs, Edwin G., DeLange, Robert L, Kemp, Robert

G., and Riley, W. Dixon. Activation ofskeletal mus-cle phosphorylase, 18, 163

Krishna, G. See Brodie et al., 18, 273Krsti#{233},M. See Varagl#{233} and Krsti#{233},18,799Kuffler, Stephen W. See Hurtt and Kuffler, 2,96Kukovetz, Walther R. See Haugaard et al., 11,466

Laemmli, U. K. Levels of organization of the DNA in

eucaryotic chromosomes, 30, 469Lambertsen, C. J. See Clark and Lambertsen, 23,39

Lande, Saul, and Lerner, Aaron B. The biochemistryof melanotropic agents, 19, 1

Lands, A. M. The pharmacological activity of epineph-rune and related dihydroxyphenylalkylamines, 1, 279

Larson, P. 5. See Silvette et al., 14, 137

Larsson, Stig. See Andersson and Larsson, 13, 1Lasagna, Louis. The clinical evaluation of morphine

and its substitutes as analgesics, 16, 47Laties, Victor G. See Weiss and Laties, 14, 1

Latt, Samuel A., Schreck, Rhona R., Loveday, Ken-neth S., and Shuler, Charles F. In vitro and in vivo

analysis of sister chromatid exchange, 30, 501Lurell, C.-B. Plasma iron and the transport of iron in

the organism, 4, 371Leander, J. D., and McMillan, D. E. Schedule-induced

narcotic ingestion, 27, 475

LeBlanc, A. E. See Kalant et al., 23, 135Lee, Kwang S., and Klaus, Wolfgang. The subcellular

basis for the mechanism of inotropic action of car-

disc glycosides, 23, 193Leeper, Lemuel C. Catecholamine formation in intact

tissues, 11, 358

Lees, G. M. See Kosterlitz and Lees, 16,301

LeFevre, H. F. See Costa et aL, 24, 167LeFevre, Paul G. Sugar transport in the red blood cell:

structure-activity relationships in substrates and an-

tagonists, 13, 39

Letkowitz, Robert J. Isolated beta-adrenergic binding

sites: a potential assay vehicle for catecholamines,25, 259

Lemberger, Louis, Axelrod, Julius, and Kopin, IrwinJ. Metabolism and disposition of �9-tetrahydrocan-nabinol in man, 23, 371

Leonard, Edward. See Hajdu and Leonard, 11, 173Lerner, Aaron B. See Lande and Lerner, 19, 1Lesniak, M. See Gorden et al., 25, 179Levi-Montalcini, Rita, and Angeletti, Piero U. Immu-

nosympathectomy, 18, 619

Levine, Lawrence. Antibodies to pharmacologicallyactive molecules: specificities and some applicationsof antiprostaglandins, 25,293

Lieberman, Seymour, and Teich, Sylvia. Recent trends

in the biochemistry of the steroid hormones, 5, 285Liebson, I. See Bigelow et aL, 27, 523

Lilienthal, Joseph L., Jr. Carbon monoxide, 2, 324Liljestrand, G. Transmission at chemoreceptors, 6,73

Lindenbaum, John. Bioavailability of digoxin tablets,

25, 229

Lindenmayer, George E. See Schwartz et al., 27, 3Lindqvist, M. See Carlsson et al., 24, 371

Llewellyn, M. E. See Iglauer et aL, 27, 367Loewe, S. Antagonism and antagonists, 9, 237Loewi, Otto. Introduction to symposium on neurohu-

moral transmission, 6, 3Longo, V. G. Behavioral and electroencephalographic

effects of atropine and related compounds, 18, 965Loveday, Kenneth S. See Latt et aL, 30, 501

Lowry, Oliver H. See Hunter and Lowry, 8,89Lundholm, Lennart, Chairman. Physiological Interre-

lationships, Section II: Metabolic Effects of Cate-cholamines, 18, 255-314; Introductory remarks, 255

MacKenzie, Eric T. See Edvinsson and MacKenzie,28, 275

Magnusson, T. See Carlsson et al., 24, 371Makinodan, T., Santos, G. W., and Quinn, R. P. Irs-

munosuppressive drugs, 22, 189

Maloof, F., and Soodak, M. Intermediary metabolismof thyroid tissue and the action of drugs, 15, 43

Mandel, H. George. The physiological disposition of

some anticancer agents, 11, 743

Mandel, William J. See Butler et al., 25, 239Manger, William Muir. Suitability of the ethyl