Biodetectorsin Defence

Equipment & Accessories

(A Guide Book)

EditorBrij M Gandhi, M.Sc, Ph.D.

Associate EditorsKapil Gandhi, MDS, MBA

Nikhil Gandhi, M.Sc.

NeoBioMed ServicesWebsite: www.neobiomed.comE-mail: info@neobiomed.com; drbmgandhi@neobiomed.com 

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Biodetectorsin Defence

Equipment & Accessories

(A Guide Book)

EditorBrij M Gandhi, M.Sc, Ph.D.

Associate EditorsKapil Gandhi, MDS, MBA

Nikhil Gandhi, M.Sc.

NeoBioMed ServicesWebsite: www.neobiomed.comE-mail: info@neobiomed.comdrbmgandhi@neobiomed.com 

Bibliographic InformationBook Title : Biodetectors in Defence, Equipment and Accessories (A Guide Book)Editors : Brij M. Gandhi, M.Sc, Ph.DAssociate Editors : Kapil Gandhi, MDS, MBA, Nikhil Gandhi, M.ScPublished By : NeoBioMed ServicesCopyright : 2016

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of publisher (NeoBioMed Services), 100, Vasant Enclave, New Delhi – 110057, India

Copyright Holder : Dr. Brij Mohan GandhieBook ISBN : 978-93-5258-504-5DOI Number :Hardcover ISBN :Series ISSN :Edition Number : FirstNumber of Pages : XVI, 383

Biodetectors In DefenceBiodetectors In DefenceEquipment & Accessories

Defence industry is dedicated to providing solutions against biological agents or toxins, and current efforts focus intensively on development of knowledge, systems and technologies for collection, detection, identification and creating new means of protection against biological threats. Fully automated biodetectors have been devised for real-time sample collection, detection, and identification in the field while taking care to maintain the highest level of sensitivity. Biodetectors are available designed for fixed and 24/7 surveillance, outdoor and indoor, which use different principles and technologies for identification and quantification of the bioagents.

The present guide reports summarized information on commercially available collectors, portable detectors and computer-based laboratory systems using advanced technologies, instrumentation and diagnostic system for detection and identification of biological warfare agents in environment, water and food samples. Information is also provided to the source of these technologies and similar technologies and systems.

The guide book provides exhaustve list of over 1100 gadgets, instruments, devices and technologies available from leading global providers (links provided). The guide is useful for educating the general public, defence industry, homeland security agencies, local, state and national governments on biological and chemical defence matters regarding available equipment and technologies to combat WMDs, terrorism, and homeland security for safety of citizens and critical infrastructure and respond to incidents of CBRNe.

You may buy e-book or you may buy individual e-chapter at www.neobiomed.comThe Editors seek information from the vendors about any new advancement in their products.Sponsor with us for Advertisement / Picture/ Company / Product (s) for incorporation in the Printed

Format of the Guide Book, expected to be printed soon* Companies’ products listed** Sponsorship form

1 Introduction 2 Diseases and Causative Agents 3 Principles / Technologies 4 Bio-Air Samplers (Aerosol Particle Collectors) 5 Aerosol Concentrators 6 Sample Collectors 7 Biological Diagnostic Tests / Kits 8 Integrated Detection Systems 9 Monitoring / Surveilliance Device 10 Detecters & Technologies 10.1 Biosensors 10.2 Chemiluminescence 10.3 Colorimetry 10.4 Electronic Sensing Technology 10.5 Flame Spectrophotometry 10.6 Flow Cytometry 10.7 Fluorescent Technologies 10.8 Imaging Systems 10.9 Immunoassay 10.10 Ion Mobility Spectrophotometry 10.11 Gas Chromatography/Mass Spectrophotometry 10.12 Lab-on-Chip

10.13 Laboratories/ Workstations 10.14 Laser Systems 10.15 Lidar Technologies 10.16 Microarray Systems 10.17 Molecular Technologies 10.18 Nanoscience Technologies 10.19 Optical Analysis 10.20 PCR Based Assays 10.21 Radiological 10.22 Raman Spectroscopy 11 Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNe) 12 Food Pathogens Detection 13 Water Contamination Detection 14 Decontamination Materials 15 Decontamination Stations 16 Protective Equipment 17 Detection Equipment and Accessories 18 Communication Accessories 19 Training Testing Equipment 20 Companies & Profile 21 Index Products 22 Disclaimer

Chapter No. Subject Chapter No. Subject

Contact Details: Dr. Brij M. GandhiChief Executive Officer, NeoBioMed Services

Former Advisor, Department of BiotechnologyMinistry of Science and Technology, Government of India

Registered Office: 100, Vasant Enclave, New Delhi-110057, IndiaPhone: (O) +91-11-41735051, 41725051 (R) 26145037, Mobile: +91-9899722444, +91-9868158944

e-mail: info@neobiomed.com, drbmgandhi@neobiomed.com Web: www.neobiomed.com 

Editor:Brij M. Gandhi M.Sc., Ph.D.

Associate Editors:Kapil Gandhi, MDS, MBANikhil Gandhi, M.Sc.

(A Guide Book)

Hundreds of companies are dedicated to providing solutions for the military defence against chemical, biological, nuclear, radiological, and high-yield explosive (CBRNE) weapons of mass destruction (WMD).

Domestic preparedness against current and emerging threats of WMDs meets the requirements of the International Treaties for detection of Biological Warfare Agents (BWAs), Chemical Warfare Agents (CWAs), Toxic Industrial Chemicals (TICs), or in the monitoring of food, air, soil, and water.

Biological agents are covered under the Biological and Toxins Weapons Convention (BTWC) and are of major concern as many of them can be manufactured, transported, and dispensed with ease; and symptoms appear much later based on incubation time as many people could become sick or die if a biological attack were to occur in a major metropolitan area. Biological Warfare Agents (BWAs) include bacterial agents, viral agents, rickettsiae and biological toxins. Rapid detection thus enables faster, efficient and tailored response as it uses new approaches to differentiate between biological infections and natural contaminants.

Chemical warfare agents are considered as the Weapons of Mass Destruction because of the destructive effects of these chemicals, which are toxic enough to be used as chemical weapons or they may be used to manufacture such chemicals. Any toxic chemical, regardless of its origin, is considered a chemical weapon unless it is used for purposes that are not prohibited: it may include use of nonliving toxic products from living organisms such as botulinum toxin, ricin, and saxitoxin and are considered as chemical warfare agents under the Chemical Weapons Convention (CWC) and provisions.

When investigating a suspicious incidence in the environment, detection of biological and chemical agents for the early responders requires identifying threat agents for planning and implementing the response systems. A number of companies are developing advanced and portable detectors using advanced technologies, instrumentation and diagnostic system, that play an important role in the early detection and identification of the biological threat agent’s release offering the possibility of rapid, accurate, and sensitive biodetectors for use in battlefield or urban settings. Advanced detection systems provide early warning, identify populations at risk and contaminated areas and facilitate prompt treatment that integrates technology, operations, and policy and provides a framework for coordinated local, state, and federal emergency response to minimize mortality and morbidity.

The effective detection of biological agents in the environment requires (a) early alert of presence of bioagents about the potential danger (b) concentration of the bio-agents in liquefied, (c) detection, (d) identification of the bioagent using immunological techniques to determine the right countermeasures. In cases of aerosolized incidence, early warning (alerts), detection and identification of bioagents becomes necessary. For investigation into powder incident, a wide variety of sample collection products, field-deployable assays and detection systems are in use to determine if the substance contains biological material and warrants further investigation.

Fully automated biodetectors have been devised for real-time sample collection, detection, and identification in the field while taking care to maintain the highest level of sensitivity. Biodetectors are available designed for fixed and 24/7 surveillance, outdoor and indoor, which use different principles and technologies for identification and quantification of the bioagents.

The present guide reports information on compatible instruments, consumables, and computer-based laboratory systems available either exclusively for detection of biological warfare agents or has the dual application capabilities of detecting both the biological warfare agents and chemical warfare agents for applications in life

Executive SummaryExecutive Summary

science and analytical chemistry. Information is also provided to the source of these technologies and similar technologies and systems. We have not picked radiological and nuclear technologies or systems for the report.

Efforts have been made to summarize commercially available technologies that can be used by first responders, military, homeland security agencies and others to investigate an unusual event that has happened or is in progress in the environment by collecting, screening and identifying the biological materials from the field.

All efforts have been made to provide accurate information of technical specifications primarily based on vendor-provided information; however, where possible the summaries have been supplemented with additional information obtained from reports and websites. Efforts are also made to provide minimum information on the performance metrics in terms of quantity or concentration of organism detected. As far possible, reference to certification by International Organization for Standardization (ISO) has also been avoided so as to minimize the biased decisions.

The aim of the report is only to provide useful information about available technologies to help end-users make informed decisions about biodetection technology procurement and use. The focus of this report is on available equipment and technologies for environmental alerts, sampling and detection, and safety of food and water from biological contaminants including information on decontaminants and protective equipment for first responders.

The purpose of this report is to provide information on types of detection technologies and not to compare the available technologies. The list is neither exhaustive and nor an endorsement of any technology described herein and similar technologies may be available from other companies. Reviewers may verify the authenticity of the details on websites.

The guide is meant for reference purposes for educating the general public, defence industry, homeland security agencies, local, state and national governments on biological and chemical defence matters regarding available equipment and technologies to combat WMDs, terrorism, and homeland security for safety of citizens and critical infrastructure and respond to incidents of CBRNe. The guide lists range of gadgets, instruments, devices and technologies available from leading global providers of instrumentation and technologies providing options best suited to these agencies to meet their requirements.

20/20 GeneSystems Inc, USA3M, USAAbbott Diagnostics, USAAbbott Ibis Biosciences, USAACE Glass Inc., USAAdaptive Methods, USAAdvanced Analytical Technologies,USAAdvanced Liquid Logic, Inc, USAAdVnt Biotechnologies, USAAerospace Corporation, USAAgilent Technologies, IndiaAir Techniques International, USAAirogistic, LLC, USAAkonni Biosystems Inc., USAAlexeter Technologies Inc., USAAlfred Kärcher GmbH, GermanyAllen-Vanguard Corporation, CanadaAlluviam LLC, USAAlpha Innotech, USAAmbri Pty. Ltd., AustraliaAmScope, USAANP Technologies®Inc., USAAnsell Occupational Healthcare, USA)Applied Biosystems Canada/Applied Nanotech, Inc, USAApplied Response Solutions, LLC, USAAqua MS, FranceAreté Associates, USAArgon Electronics, UKArmy Chemical Corp., USAArrayit Corporation, USAASD BioSystem, USAAurora Biomed, Canada/USAAxela Inc., USAAzbil BioVigilant Systems, Inc, USAB.A.S. Biological Alarm Systems, IsraelBAE Systems Inc., USABattelle, USABBI Detection Inc., UKBD Biosciences, USABeacon Analytical Systems, Inc., USABeckman Coulter, Inc, USABecton Dickinson Diagnostic Systems Bertin Technologies, FranceBiacore, Inc., USABio Rad Laboratories Inc., USABioControl Systems, Inc, USABioDetect, USA BioDetection Instruments, LLC, USABioDetection Systems b.v., NetherlandsBioDetectors Pty Ltd., AustraliaBiofire Defence, USABioFire Diagnostics Inc. USABioForce Nanosciences Inc., USABioGene Ltd, UKBiological Alarm System Ltd., IsraelBioMark, USABioMerieux Inc, USABioneer Inc, USABioquell Defence, Ireland/UKBio-Rad Laboratories Inc., USABioSentinel, USABiosite Inc, USA

BioTech International Inc., USABiotrace International, Ltd., UK/USABioVeris Corporation, USABIOVIGIL Healthcare Systems, USABiovigilant, USABiral Ltd., UKBlauer Manufacturing Co. Ltd., USABlock Engineering, USABLÜCHER GmbH ,Germany)Bridger Technologies, Inc., USABrinkmann Instruments Inc., USA, A company of Eppendorf, Germany)Bruhn NewTech, DenmarkBruker AXS, Inc., USABruker Corporation, USABruker Daltonics, Germany/UKBruker Detection Corp., USABuilding Protection Systems, Inc., USACalgon Carbon Corporation, USACaliper Life Sciences, USACamtech Diagnostics, SingaporeCanadian Ministry of DefenseCanon Chemical, Inc. under license from Research International Inc., USACapSenze, SwedenCaribbean Biotechnologies Inc, USACarl Zeiss Microscopy, GermanyCBD SBIR Program, USACBRNe Solution, USACDS Analytical Inc., USA)CEA, France Cellex, Inc. USACepheid GeneXpert Systems, USAChemering Detection Systems Inc., USAChemImage Corporation, USAChemring Detection Systems Inc., USACiencia Inc., USAClear Lake Medical Foundation , USAClimatronics Corporation, USACLONDIAG Chip Technologies, Germany now Alere Technologies GmbH, GermanyCOLE-PARMER, IndiaCombiMatrix Corporation, USAComputing Devices Canada, later General Dynamics Missions Systems,Constellation Technology Corpn, USACooperative Research, Development Coplay Scientific Limited, UKCorbett Life Science, USACorbett Research, AustraliaCristanini SPA, ItalyCustomArray, Inc, USADefiant Technologies Inc., USADiagnostic Biosensors, LLC, USADIOMED Def. Sys.Techs., TurkeyDionex Corporation, USADraeger Safety, Germany/USADuPont, USADycor Technologies Ltd, CanadaDycor Technologies, Ltd., Canada LTDEAI Corporation, USAEarly Warning, Inc., USA

ECA Robotics, FranceECA-SSI Simulator Systems Intl, USA Echo Technologies, Inc., USAEdgewood Chem. Bio. Centre ,USAELBW Technology SA, SwitzerlandElectronic Sensor Technology Inc., USAEM Science, NJ, USAem.tronic, SloveniaEmergent Biosolutions Inc., USAEnvironics Oy, FinlandEnvironics, FinlandEnvironmental Technologies Group.USEPE, AustraliaEpisensor, USAEpistem, UKesearch International, USA)Evogen, Inc., USAFAS Military Analysis Network, USAField Forensics, Inc., USAFLIR Systems Inc., USAFocus Diagnostics, Inc, USAForteBio, USAGeneFluidics, USAGeneral Dynamics, CanadaGeneReach, USAGenMark Diagnostics, USAGenomic Solutions, USAGenPrime Inc., USAGen-Probe Inc., USA and Hologic Incorporated, USAGentel Biosciences, USAGlobal Security Solutions, CanadaGlobal Security, AustriaGo!Foton, USAGroton Biosystems LLC, USAGuild Associates, Inc., USA GX Microscopes, UK Hach Company, USAHai Kang Life Corporation (L) HK Hai Kang Life Corporation Limited, UKHamilton Sundstrand Corporation, USAHandyLab Inc, USAHangzhou Bioer Technology Co., ChinaHazCat Systems, USAHazTech Systems Inc., USAHDT Global, USAHomeland Security, USAHORIBA Scientific, USAIatroQuest Corporation, CanadaICx Biosystems, USAICx Technologies, USAIdaho Technology Inc., USAILC Dover LP, USAIllumina Inc, USAImmediate Response Technologies, USAINFICON, SwitzerlandInnovaPrep LLC, USAInnovative Biosensors, Inc., USAIntegenX Inc., USAIntegrated Nano Technologies, USAIntelagard, Inc, USAInvitrogen Federal Systems, USAInvitrogen, USA

Companies’ Products Listed

Companies’ Products Listed

Ion Torrent Systems, Inc, USAIQuum, Inc. USAIsogen Life Sciences, CanadaITT Corporation, USAIVEA Solutions, FranceIzon Science Limited, New ZealandJ. Blaschke Wehrtechnik GmbH, AustriaJeol Ltd, JapanJMAR Technologies Inc, USAJohns Hopkins University Applied Physics Laboratory, USAKaercher Futuretech, GermanyKappler Inc., USAKD Analytical, USAKoch Filter Corporation, USALakeland Industries Inc., USA)Lauer Manufacturing Co. Inc., USALAURUS Systems, Inc., USALawrence Livermore National Lab, USALeica Microsystems, USALGC Forensic Science, UKLGI Consulting, FranceLife Safety Systems, Inc., USALife Sciences Advanced Technology US Life Technologies, USALockheed Martin, USALuminex Corporation, USALuminUltra Technologies, CanadaLuna Innovations USALuxfer Magtech Inc., USALynntech, Inc. USAMacherey-Nagel, GermanyMagna BioSciences LLC, USAMarshall SV, UKMassTech Inc., USAMBio Diagnostics, Inc. USAMBV AG, SwitzerlandMD Microscopes International, USAMediwell Enterprise Pte. Ltd., SingaporeMedtox Diagnostics, Inc, USAMenon International Inc., USAMesa Tech International Inc. USAMeso Scale Defence LLC, USAMeso Scale Diagnostics, LLC., USA)MesoSystems Technology, Inc., USAMesosystems, USAMet One Instruments, USAMicroFluidic Systems, USAMicronics, Inc., USAMicroscopes International, USAMIDI, Inc, USAMidwest Research Inst. Global, USAMIT Lincoln Laboratory, USAMJ Research, Incorporated, USAMolecular Devices Corporation, USAMorphix Technologies, USAMorpho Detection, USAMSA Safety Inc., USAM-Vac Systems, Inc USANano Science Instruments, USANanogen, Inc, USANanoscience Instruments, USA

Nanosphere, Inc. USANanosurf, SwitzerlandNaval Research Laboratory, USANBC-Sys, FranceNeon Engineering Corporation, USANetBio, Inc, USANew Horizons Diagnostic Corp., USANexter Group, France/GermanyNextteq LLC, USANikon Instruments Inc, USANT-MDT, RussiaOak Ridge National Laboratory, USAOlympus Corporation, JapanOlympus Life Science, USAOmni Site BioDiagnostics, Inc, USAOptiMetrics Inc., USAOsho Defence, IndiaPacific Advanced Technology, USAPacific Northwest National Lab., USAPall Corporation, USAPark Systems, Korea/USAParticle Measuring Systems, USAPartner Airogistic LLC, USAParvus Corpn.now Curtiss-Wright, USAPathogenica Inc., USAPathSensors, Inc., USA)Physical Sciences Inc., USAPositive ID TM Corporation, USAPower Engg. and Manufacturing, USAPrecision System Science Inc., USAPrinceton Gamma Tech Instruments, US Proengin, FrancePrognosys LLC, USAPromega Corporation, USAPursuit Dynamics PLC, UKQIAGEN Technical Service, USAQIAGEN, Inc, Netherlands/USAQ-linea AB, SwedenQTL Biosystems, USAQuant Technologies, USAQuantum Design Corporation, USAQuickSilver Analyst, USARapid Diagnostek, Inc. USARaptor Detection Technologies, USAR-Biopharm, Inc, USARemploy Frontline, UKResearch International, UK/USAResonant Sensors Incorporated, USARespirator ZRT, HungaryResponse Biomedical Corpn., CanadaRheonix, Inc, USARichardson Technologies Inc.,USARigaku Corporation, JapanRigaku Corporation, USARoche Applied Science, USARoche Molecular Systems Inc., USARoche NimbleGen, Inc. USARomer Labs, Inc, USASAIC, USA and Ibis Biosciences, USASandia National Laboratories, USASapidyne Instruments Inc, USASavannah River Technology Center, US

Sceptor Industries, Inc., USASceptor, USAScience & Engineering Services, USAScott Safety, UKSensidyne, USASentel Corporation, USA)Shimadzu Corporation, JapanShimadzu Scientific Instruments, USASiemens Healthcare Diagnostics, USASiemens Healthcare Global, GermanySilver Lake Research Corporation, USASKC Inc., USA)Smiths Detections Inc., UK/USASnowy Range Instruments, USASolutions 3M, USASouthern Scientific Ltd., UKSpectrex Inc., USASRC Acumen, LLC, USASRC Inc., USASRI International, USASteris Corporation, USAStratagene Inc, USASunghan Corporation Co., Ltd, ChinaSwift Optical Instruments, USASword Diagnostic, USAT2 Biosystems, USATecan Trading AG, SwitzerlandTechnologies Inc., USATecora, FranceTECRA International Pty Ltd, AustraliaTessArae, LLC, USATexas A&M University, USATex-Shield, Inc., USAThales Defence & Security, USAThales Group, France/UKThermo Electron Corporation, USAThermo Fisher Scientific Inc, USAThermo Hybaid, UKThermoBioStar, USAThird Wave Technologies Inc., USATIRF Labs, Inc., USATIRF Technologies, USATradesways Limited, USATransgenomic, USATriadic Scientific LLC, USATSI Incorporated., USATVI Corporation, USAUniversal Detection Technology, USAUS Army Edgewood Chemical Biological Centre, USAUSMC, USAVarian Instruments, USAVeredus Laboratories P. Ltd., SingaporeVeritide Ltd., New ZealandVijay Sabre Safety Pvt. Ltd, IndiaVirus Detection Systems Corpn, USAVWR International, USAWitec, GermanyWyatt-Lorenz, USAZaromb Research Corporation, USAZeptosens AG, Switzerland

Companies’ Products Listed

Companies’ Products Listed

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