Improving an ecosystem at KI to support

Innovation

We are here for you!

We believe in innovation,

but do we understand its nature?

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2Discovery:

Finding out something not yet known

Invention:

Creating or designing something not existing before

Translation:

Processing discoveries and/or invention into innovation

Innovation:

Making changes with societal impact based on discoveries and/or invention

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3/24/2017

Alexander Flemming - a discoverer who

missed the chance to become an innovator

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* Dufour, A., Carroll, S.B. (2013), ‘Great myths die hard’, Nature, October 2013, 502.

Karolinska Institutet’s vision is to

significantly contribute to the

improvement of human health(Strategy 2018)

The goal for our research is to achieve scientific

breakthroughs that change the view of human health

and disease, as well as of normal vital processes

Research results should lead to innovations and

practical applications that can be implemented

within the health service sector

Why innovation output is good and needed

• The vision & mission of KI – To improve health

• Universities are obliged by law

• Investment of society in education & research is expected to yield

novel products and services improving life quality

• Funding bodies demand more & more an innovation engagement of

their recipients

• Attractiveness and ranking of Universities are increasingly linked to

innovation output too

• Increased knowledge does not per se lead to use

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Utilization Need/

Demand

Societal

impact

Research

&

Education

Strategic key pillars to unlock innovation at KI

OWNERSHIP

Place ownership & entrepreneurship

in the centre of the Knowledge Triangle

NEED

Recognize the needs of

customers and patients

PLACE

Create eco-systems where

research, education and

business partners meet

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Research

InnovationEducation

The Knowledge Triangle

KI Strategic Innovation Agenda (KSIA)Dec 10th, 2014

The business plan to unlock innovation output

Implement an innovation governance structure

Re-assign and integrate KI’s innovation support functions

Foster novel and manage existing partnerships with industry

Support start-ups and links to SMEs

Communicate the KI innovation into the organization and to the outside world

Extend innovation & entrepreneurship education programs to all students, post-

docs and staff

Align KI innovation support functions with those at Karolinska Hospital and the

local health authority (SLL)

Provide funding & investment for proof-of-concepts

Define and deliver on Key Performance Indicators (KPIs)

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Governance:

KI’s Innovation Council -

Interconnecting Innovation players

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Internal members

Alexander von Gabain (Chair)

Richard Cowburn – Innovation Office

Anders Gustafsson – Dean of research

Carl-Johan Sundberg – Professor, Head of UBE

Carol Tischelman – Professor in innovative care, LIME

Lars Klareskog – Senior professor, Dept. MedS

Benedek Bozoky – Chairman, PhD Student assoc.

Katja Petzold – Junior faculty representative

Magnus Persson – Chair of board, KI Innovations AB

Lilian Wikström – CEO KI Innovation AB

External

Maria Lönn – Strategic Innovation Expert, SLL

Jakob Hellman – Head of Innovation dept, SLL

Anders Ekblom – Chair of board, KS

Björn Odlander – Founding partner of HealthCap

Adjuncts

Linnar Viik – Estonian IT college, ITC Strategy Advisor

Staffan Lindstrand – HealthCap

Johan Christenson – HealthCap

Jan-Olov Höög – EIT Health, KI

Agneta Stålhandske – Head of Research support, KI

Innovation Council

Education

Research

KI VCSLL IndustryKS

Vice-Chancellor

One portal to find what you need

KI Science Park

lab- & office space

Unit for

Bioentrepreneurship

Education & research

Innovation Office

Free advice,

IP advice

KI Innovations AB

Business development

Incubator

Grants

Office

Karolinska Institutet Karolinska Institutet Holding AB

Legal

Office

Career

service

Partnerships create an ecosystem and

empowerment of innovation

Examples:

• Umbrella deal with Johnson & Johnson to identify projects, to

seed finance PoCs and to finance start ups

• The Scandinavian hub of “EIT Health” on “Healthy life and

active ageing” established 2015

• SciLife Lab – A national resource within molecular

biosciences with focus on health and environmental research

• ICMC – A joint research centre on cardiovascular and

metabolic disease established in partnership with

AstraZeneca and implemented 2014

• 4D, SFOs, SWE-Tox and others…

• Academic Partnerships with Max Planck Institute, Mayo

Clinics etc.

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© Marcus Erixson

Focus of Industry Partnerships

Build excellence in Research,

Education and Innovation

Create opportunities by providing:

• Knowledge sharing

• Access to unique expertise and

competences

• Education and training of personnel

• Resources – Finances and Infrastracture

Attract global expertise and investments in

other branches

• E.g. in MedTech, IT, eHealth etc

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Seed money for fresh ideas, discoveries &

inventions

Currently:

VINNOVA (VFT and more)

by Johnson & Johnson Innovations

by EIT Health

EVP (Early verification)

In the future:

by a proof-of concept fund planned to be

set-up by KI Holding AB and Karolinska Development?

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Not only products!

Development/improvement of method

Implementation of results in health care

Social innovation

We help converting research findings

into innovations for multiple purposes

2017-03-24

Industry

Collaboration

Collaboration with

Universities,

public bodies etc

Implementation

in healthcare

Increased

funding

Start-ups

Out-licensing

INPUT:People

Ideas

Questions

Funding

Innovation

Support

In-house expertise

External consultants

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Academic researcher – your rights

Professors privilege (Lärarundantaget)

What does it mean?

How does it work in other countries and what do we have to think about

in collaborations and agreements?

… and obligations

The first steps

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Innovation Office gives advice and support regarding important details

to think about when combining academic research and utilization:

• General innovation support guidance

• IP, protection types, patent, licensing

• Regulations

• Negotiations and agreements in industry

collaboration

• Improve packaging of your idea – pitch training

§

Sharpen your grant applications

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Together with Grants Office we

can help you sharpen the impact

section in order to increase the

chances for funding

(Ex: Horizon 2020, SSF)

Funding verification at KI

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Announced at the website and in Grants Office Newsletter

Early verification, EVP (Ministry of education & research): 100–300 000 SEK

Verification Funding, VFT (VINNOVA) and ALMI: Up to 300 000 SEK

Innovation funding – external

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Calls by pharma industry/university collaborations: both money and

access to chemical compounds and other tools

SSF: 3% is set aside for “nyttiggörande”

Swelife – specific calls. Maximum 1 MSEK/project 1 year.

Pharmaceutical, med tech, diagnostics, improvement of routines or

procedures in health care, home care, outpatient care and dental care.

VINNOVA: A number of programs available.

EIT Health – Healthy living and active ageing, up to 1 MSEK EUR/year.

Next call winter 2017. Maximum 25% financing

KI EIT Health Innovation & Education

Projects (2016)

Two Innovation projects with KI coordinating PIs

MULTI-MODE – Miia Kivipelto, NVS

MiniQ – Kristina Johnell, NVS

Education activities

EIT Health Starter Lab - Hanna Jansson, UBE

MOOCs:

e-Health

Behavioral Medicine

Next call for proposals is now open: Dead-line April 12, 2017 https://internwebben.ki.se/en/eit-health-innovation-promote-healthy-living-and-active-ageing

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Collaborate with industry

Find the right business to collaborate with: a Big Pharma, SME, start-up

Support and advice during negotiation and agreement finalizing.

Establish strategic partnerships between industry and academia.

Access to professional networks

Funding of projects

Industry PhDs

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A novel partnership with industry

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Broad and non-exclusive framework agreement

J&J are embedded at KI campus and directly accessible

Areas of interest: Pharmaceuticals: diabetes and metabolics, immunology,

infectious diseases and vaccines, neuroscience and oncology, Consumer

healths, Diagnostics, devices and med tech

Accelerate translational

research and early-stage

business development

Long-term

Build networks, support educational

and outreach activities

Invest in specific assets

Commercialize Scientific Research?

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Start a company:

Business development

Support with the commercialization process

Help with company creation

Office- and lab space at KI Science Park

Administration

Work with an existing company: Develop business offer

Identify customer

Pitch

Negotiate

Legal work

Inventions from researchers at

Biomedicum – Is this the KI hot-spot?

More than 200 persons involved in ideas in various areas: Pharmaceuticals

Diagnostics

Medtech

Research tools

E-health applications

Several companies formed: Biolipox

Sprint Bioscience

Biolamina

Clanotech

Pelago Bioscience

Aerocrine

Neuronova

Salipro Biotech

NovaSAID

ZuLa Diagnostics

Glionova

…….

Critical ingredients

• Inventions based on excellent science

• Team, tools and processes

• External network of experts, entrepreneurs and collaborators

• Finaniciers and customers

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KI Innovations 2016-12-31 in a nutshell

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78

12

15X

47 000 000

63150

>500

Company deliver to SLL

SMS Livräddare Skandinavien ABCrowed-sourced CPR volunteers recruited with a cell phone app

IDF in

TeamLeif Svensson, Mårten Rosenqvist, Jacob Hollenberg, David Fredman, Mattias Ringh, Per Nordberg, Andreas Carlsson, Hjärstoppscentrum Södersjukhuset, Department of Medicine Solna and Department of Clinical Sciences Danderyd HospitalOwe SvenssonCoach @ KI Innovations: Patrik Blomquist

Q2 2014 2015 2016

Business model

Legal support

Discussion w SLL Innovation

Company foundedSMS enters

DRIVE+

Inventory of assets

Business development

Term sheet with TrygFonden in Denmark

Company deliver to VGR

Vinnova 300 000

2017

David employed

Contact with Hjärt-Lungfonden

Discussion w HSF

Moves into KISP UMS invest 1

MSEK

Brand name protected

Attgeno“Supernitro” - a novel vasodilator for life-threatening pulmonary hypertension

TeamPer Agvald, MD, PhD, Christofer Adding MD, PhD, Lars E Gustafsson MD, PhD, Dag Linnarsson, MD, PhDTeam co-champion: Charlotte Edenius, MD, PhDCoaches @ KI Innovations: Christian Krog-Jensen, Patrik Blomquist

2004 2016

First contact KI Innovation –KD not interested

Second contact w KI Innovations

Swelife SME funding

Chemical plan SPPD

2017

Obtained Novo exploratory funding

Team coach Charlotte Edenius “hired” – BD support

Awarded the KI Innovation Drive+

Company formation

Congenital HeartDisease (CHD)

ARDS, Pulmonary emboliPost major surgery

2010

First patent filed

2005

Visited NLS Days

Tox plan

Meeting investors

SEB Investment forum

KI-innovation Contest förstapris2005

Ulrika NorinCommercialising a novel target for the treatment ofAutoimmune disorders

First contact

TeamUlrika Norin, PhD student, MBBRikard Holmdahl, Group Leader, MBBCoaches @ KI Innovations: Christian Krog-Jensen, Mark Farmery

2012 2013 2014 2015

Initial activities “light touch” → plans for target validation and commercialization: screening assay,

screening, patent / freedom to operate searches

Commercial potential

obvious butkey data not

in place

2016

Accepted into START

Contact re-established when key data in place: In vivo PoC KO mice,

identification of tool compounds, assay development and structural studies

Project enters DRIVE, relationship more structured, validation activities increased

and business and partnering strategy executed

2017

Discussing with potential investors and finalising risk shared deal to

develop novel compounds

Normal rats

Deficient rats

Normal mice

Deficient

mice

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If you want to learn more

University courses and programs in entrepreneurship

o KI offers various courses for PhD students including company internship

o Teacher training courses

o Master level courses

EIT Health courses

InnovatiOnsdag / Inspiration lectures ”My Story”

Contact us for lectures and workshops focused on

IP, collaborations etc. for smaller groups!

Workshop!

A follow-up session to involve you

When? April 4, 11-13

Where? At KI Campus Solna, BZ building

About what?

Pitch training – Test and sharpen the presentation of your idea

to different audiences

Bench to Bedside – The steps

Look out for registration info!

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Biomedicum + Innovation Support 4U

Future preliminary plans for closer interaction and physical space

”Innovation Corner” + KI Library and more?

A space for:

Lectures

Helpdesk

Exhibitions

Coffee

Workshop

Etc …

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Case presentations

Pedro Réu, CMB

Mats Wahlgren, MTC

Modus Therapeutics

Agneta Richter Dahlfors, Neuro

Swedish Medical Nanoscience Center

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Thank you for listening!

E-mail us!

innovationsupport@ki.se

Read more:

ki.se/collaboration/innovation

Pedro Réu

PhD Student Frisén lab

Inventor

Winner of Mentor4Research 2015

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