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Page 2: Immune Checkpoint Inhibition Trials in MCC: Advanced ... · Presented By Selma Ugurel at 2018 ASCO Annual Meeting . ... Slides are the property the required reuse. Immune Checkpoint

Immune Checkpoint Inhibition Trials in MCC:<br />Advanced Metastatic Disease

Presented By Selma Ugurel at 2018 ASCO Annual Meeting

Page 3: Immune Checkpoint Inhibition Trials in MCC: Advanced ... · Presented By Selma Ugurel at 2018 ASCO Annual Meeting . ... Slides are the property the required reuse. Immune Checkpoint

Immune Checkpoint Inhibition Trials in MCC:<br />Advanced Metastatic Disease

Presented By Selma Ugurel at 2018 ASCO Annual Meeting

Page 4: Immune Checkpoint Inhibition Trials in MCC: Advanced ... · Presented By Selma Ugurel at 2018 ASCO Annual Meeting . ... Slides are the property the required reuse. Immune Checkpoint

Overall survival with pembrolizumab for MCC <br />

Presented By Paul Nghiem at 2018 ASCO Annual Meeting

Page 5: Immune Checkpoint Inhibition Trials in MCC: Advanced ... · Presented By Selma Ugurel at 2018 ASCO Annual Meeting . ... Slides are the property the required reuse. Immune Checkpoint

Anti-PD-1/PD-L1 in advanced MCC: <br />first-line or second-line (chemo-naïve or chemo-pretreated) ?

Presented By Selma Ugurel at 2018 ASCO Annual Meeting

Page 6: Immune Checkpoint Inhibition Trials in MCC: Advanced ... · Presented By Selma Ugurel at 2018 ASCO Annual Meeting . ... Slides are the property the required reuse. Immune Checkpoint

Anti-PD-1/PD-L1 in advanced MCC: <br />first-line or second-line (chemo-naïve or chemo-pretreated) ?

Presented By Selma Ugurel at 2018 ASCO Annual Meeting

Page 7: Immune Checkpoint Inhibition Trials in MCC: Advanced ... · Presented By Selma Ugurel at 2018 ASCO Annual Meeting . ... Slides are the property the required reuse. Immune Checkpoint

Durable response on anti-PD-1/PD-L1 ?

Presented By Selma Ugurel at 2018 ASCO Annual Meeting

Page 8: Immune Checkpoint Inhibition Trials in MCC: Advanced ... · Presented By Selma Ugurel at 2018 ASCO Annual Meeting . ... Slides are the property the required reuse. Immune Checkpoint

Which patterns of resistance do we see ?

Presented By Selma Ugurel at 2018 ASCO Annual Meeting

Page 9: Immune Checkpoint Inhibition Trials in MCC: Advanced ... · Presented By Selma Ugurel at 2018 ASCO Annual Meeting . ... Slides are the property the required reuse. Immune Checkpoint

Radiologic tumor response to pembrolizumab in patients<br />per viral status<br /><br /><br />

Presented By Paul Nghiem at 2018 ASCO Annual Meeting