idaho medicaid drug utilization review program · 2015-04-16 · urine drug screening ... this will...
TRANSCRIPT
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16 April 2015
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Follow-up to Previous Reviews
Review of any outcome studies for long term narcotic use in chronic non-malignant pain
Hospice
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Outcome Studies for Long-term Narcotic Use Chou R, Turner JA, Devine EB, Hansen RN, Sullivan SD, Blazina I, et al.
The Effectiveness and Risks of Long-term Opioid Therapy for Chronic Pain: A Systematic Review for a National Institutes of Health Pathways to Preventions Workshop
Annals of Internal Medicine Vol 162 No. 4 17 February 2015
Funded by AHRQ 3
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Purpose To evaluate evidence on the effectiveness and harms of
long-term (>3 months) opioid therapy for chronic pain in adults
Evidence was used to facilitate a National Institutes of Health Pathways to Prevention Workshop
Co-sponsored by
NIH Office of Disease Prevention
NIH Pain Consortium
National Institute on Drug Abuse
National Institute of Neurological Disorders and Stroke
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Data Analysis Effectiveness No study of opioid therapy versus no opioid therapy
evaluated long-term (> 1 year) outcomes related to
Pain
Function
Quality of Life
Opioid abuse
Addiction
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Data Analysis Harms Good and Fair Quality observational studies suggest
opioid therapy for chronic pain is associated with
Increased risk of overdose
Opioid abuse and dependence
Myocardial infarction
Increased use of medications to treat sexual dysfunction
For some harms higher doses are associated with increased risk
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Bottom Line Conclusions Evidence is insufficient to determine the effectiveness
of long-term opioid therapy for improving chronic pain and function
Evidence supports a dose-dependent risk for serious harms
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Risk Prediction Instruments for Predicting Misuse, Abuse or Addiction
Aberrant drug–related behaviors such as aberrant urine drug test results and medication agreement violations ranged from 6-37%
No study evaluated the effectiveness of risk mitigation strategies to reduce harms
Urine drug screening
Prescription drug monitoring program data
Abuse-deterrent formulations
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Rates of Opioid Abuse or Dependence
Morphine –equivalent Dose (MED)
Percentage Odds Ratio
1-36 mg/day 0.7% 14.9
> or = 120 mg/day 6.1% 122.5
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Factors Associated with Increase Risk for Misuse
History of substance use disorder
Younger age
Major depression
Use of psychotropic medications
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Review of any outcome studies for long term narcotic use in chronic non-malignant pain
Questions/Comments ???
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Hospice
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Hospice
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Hospice CMS Update – July 18, 2014
Hospice providers should provide all the medications that are reasonable and necessary for the palliation and management of a beneficiary’s terminal illness and related condition.
This will routinely include drugs in these four categories:
1) Analgesics
2) Antinauseants (antiemetics)
3) Laxatives
4) Antianxiety drugs (anxiolytics)
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Hospice Hospice Diagnoses
Effective October 1, 2014: hospice agencies can no longer use Debility or Adult Failure to Thrive as a hospice diagnosis.
Idaho Medicaid is seeing an increase in Malnutrition and Nutritional Marasmus listed as hospice diagnosis.
The Pharmacy Unit had a meeting with the Medical Care unit who coordinates hospice care to express concern over the use of these non-specific diagnoses for patients with multiple chronic disease states (e.g. congestive heart failure, diabetes, kidney failure).
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Hospice – Prior Authorization Requests for
Idaho Medicaid to Pay for Medications
Analysis of Requests Received Jan. – Dec. 2014
Requests received for 42 patients
164 total medication requests
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Hospice Patients no longer on
hospice, n=11, 26%
Patients currently on
hospice, n=31, 74%
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Hospice
Medication requests for patients no longer on
hospice, n=55, 34%
Medication requests for
patients currently on
hospice, n=109,
66%
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Hospice
Approved, n=45, 41%
Denied, n=64, 59%
109 Medication Requests for Patients currently on hospice
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Hospice
35
23
6
0
5
10
15
20
25
30
35
40
Insufficient documentation
Hospice should cover Medication should be discontinued
Denial Reasons (n=64)
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Hospice Examples of medications that hospice should cover
Pain medications
Nausea medications
Management of terminal illness
Examples of medications that should be discontinued
Metformin in patient with kidney failure
Calcium and iron supplements
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Hospice 1. Improve communication between Medical Care Unit
and Pharmacy Unit
- Pharmacy Unit needs to be notified when patients are NO LONGER on hospice.
- Appropriate hospice diagnoses
2. Pharmacy Unit will continue to provide feedback to hospice
- Required documentation
- Medication classes that hospice needs to cover
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Hospice Questions/Comments ???
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Ongoing Reviews Foster Children 2014
Hydrocodone compound products update
Buprenorphine
Hepatitis C
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2014 Update
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Use of Psychotropic Medications in Foster Children
Percentage of children (0-17 years old) prescribed psychotropic Medications in named State and year
Foster Children Nonfoster children Ratio of foster to nonfoster children
Florida 2008 22.0% 8.2% 2.7
Massachusetts 2008 39.1% 10.2% 3.8
Michigan 2008 21.0% 7.9% 2.7
Oregon 2008 19.7% 4.8% 4.1
Texas 2008 32.2% 7.1% 4.5
Idaho 2008 38.8% 14.8% 2.6
Idaho 2011 42.9% 14.8% 2.9
Idaho 2012 44.6 % 15.7 % 2.8
Idaho 2013 43.6% 15.8% 2.8
Idaho 2014 46.1% 16% 2.9
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Comparison of Idaho Medicaid to Five States in GAO Study
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Foster Children and Non-Foster Children Population Basis
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Year Total # of Foster Children
Total # of Non-Foster Children
2007 2,384 85,894
2008 2,516 86,419
2009 2,658 96,979
2010 2,718 103,199
2011 2,785 106,024
2012 2,631 104,553
2013 2,708 105,915
2014 2,707 110,337
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Percentage of Children Receiving Psychotropic Medications Over Time
2007 2008 2009 2010 2011 2012 2013 2014
Foster 34% 39% 39% 41% 43% 45% 44% 46%
Non-Foster 14.4% 14.8% 14.4% 14.3% 14.8% 15.7% 15.8% 16.0%
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
50%
Pe
rce
nta
ge
of
Ch
ild
ren
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Percent of Total Foster and Non-Foster Children Receiving Psychotropics by Class 2014
39%
6% 6%
25%
19%
10%
2% 2%
7% 4%
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
ADHD Antianxiety Mood Stabilizers Antidepressants Atypical Antipsychotics
% Foster % Non-Foster
Total Foster = 2707 Total Non-Foster = 110,337
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Total Claims and Cost Comparison Foster and Non-Foster Children Drug Class Foster
Children Claims
Non-Foster Children Claims
Foster Children
Cost
Non-Foster Children Cost
ADHD 10,394 88,052 $ 1,119,792 $ 10,968,106
Antianxiety 626 7,539 $ 10,208 $ 116,780
Mood Stabilizers 890 11,476 $ 30,236 $ 877,091
Antidepressants 5,066 47,913 $ 66,450 $ 698,506
Atypical Antipsychotics
4,361 29,192 $ 879,571 $ 6,762,859
Total 21,337 134,172 $ 2,106,259 $ 19,423,342
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Claims Comparison Foster Children and Non-Foster Children
3.84
0.23 0.33
1.87 1.61
7.88
0.8
0.07 0.1 0.43 0.26
1.67
0
1
2
3
4
5
6
7
8
9
ADHD Antianxiety Mood Stabilizers Antidepressants Atypical Antipsychotics
Total
Claims per Foster Child Claims per Non-Foster Child
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Cost Comparison Foster Children and Non-Foster Children
$414
$4 $11 $25
$325
$778
$99
$1 $8 $6 $61
$176
$-
$100
$200
$300
$400
$500
$600
$700
$800
$900
ADHD Antianxiety Mood Stabilizers Antidepressants Atypical Antipsychotics
Total
Cost per Foster Child Cost per Non-Foster Child
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Percent of Foster Children Receiving Psychotropics by Year
2011 2012 2013 2014
ADHD 48% 38% 39% 39%
Antidepressants 14% 24% 23% 25%
Mood Stabilizers 10% 6% 6% 6%
Atypical Antipsychotics 21% 21% 20% 19%
0%
10%
20%
30%
40%
50%
60%
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ADHD Drugs in Foster Children
6%
2%
34%
18%
24%
16%
8%
3%
40%
15%
23%
11%
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
0-6 M 0-6 F 7-12 M 7-12 F 13-17 M 13-17 F
Foster (total = 1050) Non-Foster (total = 11,154)
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Mood Stabilizers in Foster Children
3% 2%
22%
13%
35%
25%
7%
4%
21%
15%
25% 28%
0%
5%
10%
15%
20%
25%
30%
35%
40%
0-6 M 0-6 F 7-12 M 7-12 F 13-17 M 13-17 F
Foster (total = 151) Non-Foster (total= 1996)
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Antidepressants in Foster Children
2% 0%
19%
14%
30%
36%
2% 1%
20%
12%
26%
39%
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
0-6 M 0-6 F 7-12 M 7-12 F 13-17 M 13-17 F
Foster (total = 665) Non-Foster (total = 8186)
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Atypical Antipsychotics in Foster Children
5%
1%
28%
13%
33%
20%
7%
2%
30%
12%
29%
21%
0%
5%
10%
15%
20%
25%
30%
35%
0-6 M 0-6 F 7-12 M 7-12 F 13-17 M 13-17 F
Foster (total = 518) Non-Foster (total = 3995)
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Prescriber Type by Claims Volume Statewide
Child and Adolescent Psychiatrist
5%
Psychiatrist 21%
Behavioral/ Developmental
Pediatrician 3%
Pediatrician 14%
Family Medicine/General Practice/Internal
Medicine 13%
Nurse Practitioner 34%
Physician Assistant 9%
Other 1%
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Change in Prescriber Type 2013 and 2014
Prescriber Type 2013 2014
Child and Adolescent Psychiatrist 18% 5%
Psychiatrist 13% 21%
Behavioral/Developmental Pediatrician 5% 3%
Pediatrician 13% 14%
Family Medicine/General Practice/Internal Medicine 19% 13%
Nurse Practitioner 22% 34%
Physician Assistant 7% 9%
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Regional Prescriber Variation 2013: By Prescriber Type
0%
10%
20%
30%
40%
50%
60%
70%
80%
% Specialist % Generalist % Midlevel
Prescriber Type by Region By Percentage of Psychotropic Prescriptions for Foster Children 2014
Region 1
Region 2
Region 3
Region 4
Region 5
Region 6
Region 7
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Regional Prescriber Variation 2013: Prescriber Type By Region
17%
4%
33%
18%
45%
25%
69%
39%
48%
18%
24%
32%
52%
16%
44%
48% 49%
58%
23% 24%
15%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Region 1 Region 2 Region 3 Region 4 Region 5 Region 6 Region 7
% Specialist
% Generalist
% Midlevel
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Foster Children and Psychotropic Drugs
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Questions/Comments ???
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April 2015
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Background
All new prescriptions for Hydrocodone combination products are Schedule II as of October 6, 2014
These drugs rank number 1 in utilization by volume for Idaho Medicaid
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DUR Board Questions How will this effect other Opioid initiatives?
> 1 long-acting
> 1 short-acting
> 300 mg daily morphine equivalents
What shift in other agent utilization will be seen?
Tramadol
Acetaminophen with Codeine
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8028
7012 6932
6277
7078 7058 7055
1750 1771 1678 1655 1771 1777 1823
504 699 611 558 637 677 618
0
1000
2000
3000
4000
5000
6000
7000
8000
9000
Sep-14 Oct-14 Nov-14 Dec-14 Jan-15 Feb-15 Mar-15
Hydrocodone Combination Products and Alternatives by Claim Count
Hydrocodone Combinations
Tramadol/Tramadol + APAP
APAP and Codeine
47
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$156,215
$137,568 $143,492
$130,098
$145,991 $147,988
$179,478
$22,363 $22,500 $21,586 $21,118.45 $22,500.36 $22,997.04 $23,169.74
$6,630 $9,140 $8,163 $7,391.53 $8,206.91 $8,604.35 $8,055.70
$-
$20,000
$40,000
$60,000
$80,000
$100,000
$120,000
$140,000
$160,000
$180,000
$200,000
Sep-14 Oct-14 Nov-14 Dec-14 Jan-15 Feb-15 Mar-15
Hydrocodone Combination Products and Alternatives by Expenditures
Hydrocodone Combinations
Tramadol/Tramadol + APAP
APAP and Codeine
48
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6425
5828 5737
5331
5947 5888 5965
1546 1540 1457 1453 1543 1538 1615
472 639 558 512 584 618 566
0
1000
2000
3000
4000
5000
6000
7000
Sep-14 Oct-14 Nov-14 Dec-14 Jan-15 Feb-15 Mar-15
Hydrocodone Combination Products and Alternatives by Unique Recipients
Hydrocodone Combinations
Tramadol/Tramadol + APAP
APAP and Codeine
49
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61.20
64.96
70.41 69.94 68.18
71.43 71.87
$19.27 $19.45 $20.55 $20.59
$16.16
$20.70
$25.35
12.96 13.95 14.21 14.29 13.90 14.23 13.83
0.00
10.00
20.00
30.00
40.00
50.00
60.00
70.00
80.00
Sep-14 Oct-14 Nov-14 Dec-14 Jan-15 Feb-15 Mar-15
Hydrocodone Combination Product Prescription Characteristics
Average Quantity per Claim
Average Payment per Claim
Average Days Supply per Claim
50
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Hydrocodone Compounds
51
Questions/Comments ???
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Buprenorphine DUR
52
PMP Interconnect Search
More states have been added to the list (must select each individual state to search) – up to thirteen now including Idaho (new one from last quarter in Yellow)
Colorado Mississippi
Illinois Nevada
Indiana New Mexico
Kansas North Dakota
Michigan Ohio
Minnesota Utah
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Buprenorphine DUR Identified all participants with at least one claim
paid for oral buprenorphine by Idaho Medicaid between 12/1/14 to 2/28/15. n=223
Ran Board of Pharmacy report for all of these participants to identify anyone who had received any other opioid with overlapping days of service and noted payment method (cash, Idaho Medicaid, other insurance).
53
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Buprenorphine DUR
When Idaho Medicaid identifies patients on oral buprenorphine, they are blocked from payment for any other opioid.
54
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Buprenorphine DUR
200
26
201
27
210
23
223
20
222
36
211
31
212
20
223
31
0
50
100
150
200
250
Total number of participants on oral buprenorphine
Participants who paid cash for an opioid while on oral
buprenorphine
2/1/2013 - 4/30/2013
6/1/2013 - 8/31/2013
9/1/2013 - 11/30/2013
12/1-2013 - 2/28/2014
3/1/2014 - 5/31/2014
6/1/2014 - 8/31/2014
9/1/2014 - 11/30/2014
12/1/2014 - 2/28/2015
55
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Buprenorphine DUR
17
10
6
2 2 1 1
Other Opioids Dec 2014 – Feb 2015
hydrocodone
oxycodone
tramadol
hydromorphone
codeine
fentanyl patch
methadone
56
17
11
1
7
1 1 1 1
Other Opioids Jun – Aug 2014
hydrocodone
oxycodone
fentanyl patch
tramadol
hydromorphone
methadone
morphine
codeine
12
7
1
3
1 1 1
Other Opioids Sep – Nov 2014
hydrocodone
oxycodone
fentanyl patch
tramadol
methadone
morphine
codeine
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Buprenorphine DUR
Called Suboxone Prescribers
Was prescriber aware of other opioids paid for with cash?
What was the consequence to the patient?
57
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Buprenorphine DUR
23
4 4
0
5
10
15
20
25
MD Aware MD Not Aware No Call Back
# o
f p
ati
en
ts
Contacted Prescribers of Patients Who Paid Cash for Other Opioids
58
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Buprenorphine DUR
59
4
9
5
5
MD Aware
Contacted us ahead of time
Aware and counseled patient
Aware - pt having surgery/kidney stones/car accident
Aware and already discharged patient from Suboxone program
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Buprenorphine DUR
60
Feedback from prescribers
Prescribers are appreciative of the information provided
All prescribers are using the Idaho Board of Pharmacy PMP report
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Buprenorphine DUR
61
Questions/Comments ???
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Christopher Johnson PharmD
Pharmacy Service Specialist
62
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Hepatitis-C Update Review of Jan-Mar 2014 Hepatitis-C treatment requests.
New FDA approved agents:
Harvoni (10/10/2014)
Combination of Ledipasvir (NS5A inhibitor) and Sofosbuvir (Nucleotide analog NS5B polymerase inhibitor)
Viekira Pak (12/19/2014)
Combination of Ombitasvir (NS5A inhibitor), paritaprevir (HCV NS3/4A protease inhibitor), ritonavir (protease inhibitor), and dasabuvir (non-nucleoside NS5B polymerase inhibitor)
63
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64
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65
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66
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67
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68
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Hepatitis-C Update Updated therapeutic criteria and prior Authorization form for newer agents.
• General guidelines for approval as a group instead of individual agents.
Questions/Comments?
69
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Current Interventions/Outcomes Studies Foster children high utilizers
Ziprasidone multiple dosage strengths
Synagis
Continuous oral plus injectable AAP
DUR Annual Report – Other state highlights/comparison
ADURS Annual Meeting
70
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Calendar Year 2014
71
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72
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Foster Children on Psychotropic Drugs 2014
Total Foster Children on
Psychotropic Drugs
High Utilizers * Percent High
Utilizers
Total Foster Children meeting criteria
2172 65 3%
Psychotropic Drug Claims
21,780 3,942 18%
Claims/Child 10 50 – 87 N/A
Total Cost Foster Children
$2,129,568 $ 432,935 20%
Cost/Child $ 989 (range $2-$25,467)
$ 6,660 (range $330 - $25,467)
N/A
* > 50 psychotropic drug claims during calendar year 2014 73
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Age and Gender Characteristics for High Utilizers 2014
1 0
20
11
22
11
0
5
10
15
20
25
0-6 Male 0-6 Female 7-12 Male 7-12 Female 13-17 Male 13-17 Female
74
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Comparison 2013 and 2014 2013 2014
High Utilizers 68 65
Percent High Utilizers 6% 3%
Psychotropic Drug Claims 7381 3942
Percent of Total Drug Claims 21% 18%
Claims per child 50-97 50-87
Average Cost per high utilizer child $ 6100 $ 6600
Range of Cost $ 71- $ 22,513 $ 330- $ 25,467
% 0-6 years old male 3% 2%
% 0-6 years old female 0 0
% 7-12 years old male 25% 31%
% 7-12 years old female 13% 17%
% 13-17 years old male 44% 34%
% 13-17 years old female 15% 17%
75
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Comparison Individuals 2013 and 2014
Characteristic Number of Children
Children who had > 50 psychotropic claims in both 2013 and 2014
30
Children with > 50 psychotropic claims in 2014, but not in 2013
• Increase ranged from 3-53 more claims in 2014 • 3 were new to Medicaid in 2014
34
Children with > 50 claims in 2013, but < 50 in 2014 • Some no longer on Medicaid
37
76
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Children with > 50 Psychotropic claims in both 2013 and 2014
Characteristic Number Range
Decrease in total claims 16 1-40 less
Increase in total claims 13 2-21 more
No change 1
77
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78
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Patient 001 16 year old male
Psychiatric Diagnoses 313.9: Unspecified emotional disturbance of childhood
296.33: Recurrent Major Depressive Disorder
311: Depressive disorder
V62.84: Suicidal Ideation
Other Diagnoses 278.00: Obesity
401.9: Hypertension
277.7: Dysmetabolic Syndrome
493.90: Asthma, Unspecified
79
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Patient 001
Number of claims 2013: 87
Number of claims 2014: 87
Change in Claims: 0
Current Active claims/month: 3 -4
Currently receiving weekly mental health services
Monitoring labs completed: thyroid, CBC, comprehensive metabolic
80
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Current Medications (001)
Medication Daily Dose
Guanfacine 3mg
Methyphenidate 27 mg
Oxcarbazepine 1200 mg
Hydroxyzine 50 mg
Montelukast 10 mg
Fluticasone 50 mcg
Ranitidine 300 mg
ProAir 90 mcg
Metformin 1000 mg
81
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Prescribers (001) 5
3 family practice for non-mental health drugs
2 nurse practitioners for mental health drugs
82
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Patient 002 10 year old male
Psychiatric Diagnosis
None listed
Other Diagnosis 278.00: Obesity
83
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Patient 002
Number of claims 2013: 76
Number of claims 2014: 78
Change in Claims: +2
Current Active claims/month: 9 (2 for dose splitting)
No mental health services or labs in last 6 months
84
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Current Medications (002)
Medication Daily Dose
Trazodone 150 mg
Divalproex ER 750 mg
Quetiapine 75 mg
Olanzapine 15 mg
Clonidine 0.3 mg
Adderall 30 mg
Methylphenidate 55mg
85
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Prescribers (002) 4
all nurse practitioners for mental health drugs
86
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Patient 003 13 year old male
Psychiatric Diagnoses
314.01: ADHD
296.90: Episodic mood disorder
299.90: Pervasive Developmental disorder, unspecified
Other Diagnosis
783.41: Failure to thrive
87
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Patient 003 Number of claims 2013: 74
Number of claims 2014: 81
Change in Claims: +7
Current Active claims/month: 6
No mental health services
Monitoring labs completed: thyroid, CBC, comprehensive metabolic, lipid panel
88
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Current Medications (003)
Medication Daily Dose
Clonazepam 4 mg
Clonidine 0.15 mg
Adderall 10 mg
Adderall XR 30 mg
Abilify 30 mg
Citalopram 20 mg
89
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Prescribers (003) 2
Both pediatricians
90
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Patient 004 7 year old male
Psychiatric Diagnoses 313.9: Unspecified emotional disturbance of childhood
314.01: ADHD
301.3: Explosive Personality (borderline personality disorder)
299.80: Pervasive developmental disorder
296.90: Episodic mood disorder
Other Diagnosis
- none
91
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Patient 004
Number of claims 2013: 92
Number of claims 2014: 83
Change in Claims: -9
Current Active claims/month: 5
Currently receiving weekly mental health services
Monitoring labs completed: thyroid, CBC, comprehensive metabolic
92
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Current Medications (004) Medication Daily Dose
Chlorpromazine 150 mg
Quetiapine 25 mg
Intuniv 4 mg
Focalin XR 15 mg
Trazodone 100 mg
On 10/3 was given concurrent prescriptions for Abilify, olanzapine and quetiapine.
93
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Prescribers (004) 2
Both physician assistants
94
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Patient 005 14 year old male
Psychiatric Diagnoses 299.00: Autistic disorder
314.01: ADHD
309.81: Post-traumatic stress disorder
299.80: Other specified pervasive developmental disorders
312.30: Impulse control disorder
Other Diagnosis 307.42: Persistent insomnia
95
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Patient 005
Number of claims 2013: 70
Number of claims 2014: 84
Change in Claims: + 14
Current Active claims/month: 4-5
Currently receiving weekly mental health services
Monitoring labs completed: none
96
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Current Medications (005)
Medication Daily Dose
Citalopram 60 mg (40 + 20 mg)
Abilify 15 mg
Guanfacine 3 mg
Vyvanse 50 mg
Prazosin 2 mg
Hydroxyzine 50 mg
Ranitidine 300 mg
Cetirizine 10 mg
Montelukast 10 mg
Pantoprazole 40 mg
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Prescribers (005)
2
1 nurse practitioner
1 physician assistant
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Foster children high utilizers
Questions/Comments ???
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Multiple Dosage Forms of Ziprasidone Prescribed Concomitantly
100
Usual maximum FDA approved daily dose for ziprasidone (Geodon) is 160mg.
Capsules available in the following strengths:
20mg
40mg
60mg
80mg
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Multiple Dosage Forms of Ziprasidone Prescribed Concomitantly
101
Baseline
Paid claims for oral ziprasidone between 9/1/2014 and 11/30/2014 were evaluated.
85 patients identified with two or more fills for two or more capsule strengths
66 (78%) on ≤ 160mg daily
19 (22%) on > 160mg daily
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Multiple Dosage Forms of Ziprasidone Prescribed Concomitantly
102
Paragraph in letter: The usual maximum recommended daily dosage for ziprasidone is
160mg (80mg twice daily). The DUR board is reviewing Idaho Medicaid participants who are receiving more than 160mg/day of ziprasidone using multiple capsule strengths. As of 3/1/15, multiple strengths of ziprasidone capsules will no longer pay at the pharmacy without prior authorization. During a recent review it was noted that your patient, $MEMBER NAME, has been receiving more than 160 mg/day of ziprasidone using multiple capsule strengths. If you feel that it is clinically justified for your patient to remain on multiple strengths of ziprasidone capsules, please submit a quantity override prior authorization request for review by the department. A copy of
this form is enclosed for your convenience.
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Multiple Dosage Forms of Ziprasidone Prescribed Concomitantly
103
DUR letter sent to prescribers of 19 patients on 1/14/2015.
As of 3/23/2015
9 - No response, still on same dose
2 - No response, but dose decreased to ≤ 160mg daily
3 - No response, but drug discontinued
4 - Quantity override request received
1 - Patient no longer eligible for Medicaid
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Multiple Dosage Forms of Ziprasidone Prescribed Concomitantly
104
Paid claims for oral ziprasidone between 1/1/15 and 3/8/15 were evaluated.
65 patients identified with two or more fills for two or more capsule strengths
48 on ≤ 160mg daily
17 on > 160mg daily
Nine repeat patients from 9/1/14 – 11/30/14
Eight new patients identified
Second round of DUR letters sent on 3/25/2015
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Multiple Dosage Forms of Ziprasidone Prescribed Concomitantly
105
6
4
1
6
0
1
2
3
4
5
6
7
180mg 200mg 220mg 240mg
Daily dose > 160mg, n=17 1/1/15 – 3/8/15
Patients
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Multiple Dosage Forms of Ziprasidone Prescribed Concomitantly
106
Plan:
Sent out two batches of DUR letters to prescribers of patients who were receiving > 160mg daily.
Magellan has created a new initiative to make therapeutic duplication for multiple capsule strengths of ziprasidone a “hard stop” edit. Same as was done for olanzapine on 6/17/2014.
Hard Stop for multiple dosages of ziprasidone was initiated on 4/1/2015.
Proactively entered duplicate therapy prior authorization for patients on ≤ 160mg daily
Feedback to date:
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Multiple Dosage Forms of Ziprasidone Prescribed Concomitantly
107
Questions/Comments ???
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Synagis
131
81
As of 4-7-2015, 212 prior authorization requests have been processed
Approved
Denied
108
Only 12 requests denied because of new 2014 AAP criteria
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Synagis
109
Idaho Medicaid is authorizing Synagis from Dec 1, 2014 to April 30, 2015 if patients meet criteria for a maximum of five doses.
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Synagis Questions/Comments ???
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Christopher Johnson PharmD
Pharmacy Service Specialist
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Long Acting Injectable Antipsychotics (LAIA)
Idaho Medicaid is observing treatment of LAIA with oral long acting antipsychotics.
Evaluate the impact of this practice.
Guidelines are limited with LAIA recommendations
Commonly used in patients with non-compliance, frequent relapses or who pose a risk to others.
Recommendations to consider LAIA to any patient for whom maintenance antipsychotic treatment is indicated (BMC Psychiatry 2013, 13:340)
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Aripiprazole (Abilify®, Abilify Discmelt ®, Abilify Maintena®) FDA approved indications:
Autistic disorder - Psychomotor agitation.
Bipolar disorder - Psychomotor agitation.
Bipolar I disorder, Adjunctive therapy with lithium or valproate.
Bipolar I disorder, Monotherapy, manic or mixed episodes.
Gilles de la Tourette's syndrome.
Major depressive disorder, Adjunctive treatment in patients receiving antidepressants.
Psychomotor agitation – Schizophrenia.
Schizophrenia.
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Risperidone (RisperDal®, Risperdal® Consta ®) FDA approved indications:
Bipolar I disorder
Schizophrenia
Autistic disorder
Risperdal® Consta ® is approved for the treatment of schizophrenia or as monotherapy or as adjunctive therapy to lithium or valproate for the maintenance treatment of Bipolar I disorder.
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Paliperidone (Invega®, Invega® Sustenna ®)
FDA approved indications:
Schizoaffective disorder
Schizophrenia
Invega ® Sustenna ® is approved for the treatment of schizophrenia or schizoaffective disorder as monotherapy and as an adjunct to mood stabilizers or antidepressants.
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Injectable Atypical Antipsychotics
Use with oral paliperidone (Invega®) or with risperidone (RisperDAL®)
Concomitant use of Invega® Sustenna® with oral paliperidone or oral or injectable risperidone has not been studied. Since paliperidone is the major active metabolite of risperidone, consideration should be given to the additive paliperidone exposure if any of these medications are coadministered with Invega® Sustenna®.
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Continuous Oral Plus Injectable Atypical Antipsychotics Data suggest crossover use of oral and injectable
agents
Starting on oral agents and transitioning to injectable or vice versa.
Concurrent use of oral long acting atypical
antipsychotics and long acting injections is limited.
No guidelines for the concurrent use of oral and injectable use of the same agents.
Questions/Comments?
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Federal Fiscal Year 2013
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Background Each State Medicaid Program is required to submit an
annual report on the operation of its Medication DUR Program
Prescribing patterns
Cost Savings generated from DUR
Program operations
Adoption of new innovative DUR practices
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General Information Physician administered drugs : 10 states have
redesigned their MMIS systems to incorporate Physician Administered Drugs into their DUR criteria (prospective and retrospective)
DUR activities saved an average of 18% on drug cost savings/cost avoidance compared to the total drug spend
Range is 0-73%
Idaho is 14%
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Medication Therapy Management CMS Approval
Colorado
Florida
Iowa
Minnesota
Missouri
Oregon
Wisconsin
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Fraud, Waste and Abuse Detection
Identification of Fraud and Abuse –documented process
Beneficiary – all states but South Dakota
Prescriber Fraud – 38 states
Pharmacy Fraud – 34 states
Actions taken
Denying claims
Alerting Integrity or Compliance Unit to investigate
Referring to licensing Board or another governmental agency such as Attorney General, OIG, DEA
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Lock-in Criteria
49 states have Lock-in programs
Criteria
Number of controlled substances 41
Different prescribers of CS 47
Multiple pharmacies 47
Number days’ supply of CS 21
Exclusivity of short-acting opioids 11
Multiple ER visits 33
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Prescription Monitoring Programs
PDMP in all but one state (Missouri)
27 states have ability to query the database
Only 7 states require prescribers to access the patient history of the database prior to prescribing controlled substances
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Morphine Equivalent Daily Dose (MEDD) 9 states have set limits
including WA, OR, WY at 120
8 states have an algorithm in their POS system that alerts the pharmacy provider that the morphine equivalent daily dose prescribed has been exceeded
11 states give providers information on how to calculate the MEDD
3 states require that Pain Management providers be certified
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Psychotropic Drugs Second Generation Antipsychotics
KY: all require a diagnosis MO: Clinical consultant review for < 5 years SC: < 6 years requires psyche assessment, informed consent WI: Child and adolescent psychiatrists review and adjudicate
PAs
WA: Psychotropics not meeting thresholds (ex. 5 or more polypharmacy) require consult with contract Pediatric Mental Health experts
WY: Patient that exceed limits (too young, high dose, therapeutic duplication, > than 5 psychotropics ) are referred to Seattle Children’s Hospital for second opinion review
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Stimulants Stimulants in Adults
Not paid for in California
Delaware – must fail 2 long-acting before can get a short-acting
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Innovative Practices
Controlled substances
Mailing to Top Prescribers of Controlled Substances: CT
Biweekly High Dose Narcotic/Therapeutic Case Management Workgroup for complex narcotic cases: MA
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Innovative Practices
Children on Psychotropics
Dashboard: OR
Consult required: VA, VT
Atypical Antipsychotic Metabolic Monitoring: MD
Peer Review Program for mental health drugs: MD
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Innovative Practices
Statin Medication Therapy Management: ME
Provider Outreach/Academic Detailing: MA, MI
Online Provider Education Modules: TX
Live Provider Education: IL, MI
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Innovative Practices
Hemophilia Management: IL, MI, WA
Pharmacy Case Management: MT
Benzodiazepine restrictions: DE
Informed Consent on high risk or high dollar medications: DE
Prior authorization on drug shortages: IL
Prohibit Automatic Refills: IL
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(American Drug Utilization Review Society)
February 26-28, 2015
39 states sent representatives to this meeting.
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ADURS Annual Meeting Two speakers on hepatitis C
1. MD from Delaware
Background on disease state
Potential therapeutic targets in the HCV replication cycle
Review of current therapeutic treatment guidelines
His personal “possibly reasonable criteria for approval”
Included NOT treating patients unless they are drug abuse/alcohol abuse free for one year
Not treating patients with life expectancy less than one year
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ADURS Annual Meeting Two speakers on hepatitis C
2. PharmD from Massachusetts Medicaid
Reviewed first 500 patients with HCV who received treatment with the new agents
Clinical pharmacy service involvement
Review genotype and liver disease stage for appropriateness of therapy chosen
Check that approved patients actually filled their prescriptions
Require follow-up SVR at 12 weeks
Concerning that 31 of 380 patients who have completed therapy still have detectable viral load AFTER treatment has been completed
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ADURS Annual Meeting Delaware’s Limits on High Dose Immediate Release
Oxycodone
Instituted March 1, 2012
Oxycodone 30mg IR: 60 units per YEAR
Oxycodone 20mg IR: 120 units per YEAR
Oxycodone 15mg IR: 240 units per YEAR
Huge increase in number of prescriptions for short acting opioids
By Q3 2014 92% of all short acting opioids were for ≤ 60 pills/fill
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ADURS Annual Meeting National Association of Medicaid Directors
Pharmacy workgroup launched in 2013
Goal is to improve communication between CMS and state pharmacy administrators
Monitor legislation in Senate and Congress
Using Pharmacy Quality Measures in Medicaid DUR Programs
Measurement ALONE is not enough, must be part of quality improvement initiatives
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ADURS Annual Meeting CMS: A Federal Update of DUR in Medicaid
Discussed annual state DUR program survey
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ADURS Annual Meeting New Drugs 2015
Antibiotics: Dalvance, Sivextro, Orbactiv, Zerbaxa
Hepatitis C: Sovaldi, Harvoni, Viekira PAK
Allergies: Grastek, Ragwitek
CV: Zontivity
Sedatives: Belsomra
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ADURS Annual Meeting New Drugs 2015
Respiratory: Striverdi
Diabetes: Jardiance, Tanzeum, Trulicity, Afrezza
Constipation: Movantik
Anticoagulant: Savaysa
Nail fungus: Jublia
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ADURS Annual Meeting Pipeline Preview 2015
Oncology drugs approximately 1/3 of drugs in pipeline
Narcotics: abuse deterring agents are a high priority
Multiple sclerosis
Diabetes
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ADURS Annual Meeting Risk and Benefit of Concomitant Benzodiazepines and
Opiates
Speaker from University of Mass Medical School/Clinical Pharmacy Services
In patients who abuse opioids, 75% are also on benzodiazepines
Often started as prescriptions from two separate prescribers
Greater respiratory depression and increased euphoria when on both benzodiazepines and opiates
Usually wean off benzodiazepines first
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ADURS Annual Meeting Psychotropic Medication Monitoring Program for
Children in Texas Foster Care
Court authorizes DFPS or an individual to consent to medical care
If DFPS is authorized, a specific individual must be designated
May be live-in caregiver, emergency shelter staff, cottage parents in children’s home
Medical consenter must complete online training on informed consent
Medical consenter must participate in each medical appointment of child
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ADURS Annual Meeting Psychotropic Medication Monitoring Program for
Children in Texas Foster Care
Children taking psych meds must be seen by prescriber every 90 days (minimum)
Mandatory review (peer-to-peer) with child psychiatrist if:
Four or more psychotropic medications prescribed concomitantly
Two or more stimulants or antidepressants or antipsychotics
Exceed maximum FDA approved dosing
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ADURS Annual Meeting Questions/Comments ???
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Proposed Studies for Next Quarter: Narcotics > 1 LAO
Antipsychotics in children and ER visits
Narcotics: short-acting > long-acting
Buprenorphine plus benzodiazepines
Atypical Antipsychotics without metabolic testing
Abilify multiple dosage strengths
Atypical Antipsychotics in children ≤ 6 years of age
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Narcotics > 1 LAO
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Antipsychotics in children and ER visits
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Request to consider DUR of prevalence of adverse effects associated with antipsychotics in Medicaid Pediatric population.
Hampton LM, Daubresse M, Chang H, Alexander G, Budnitz DS. Emergency Department Visits by Children and Adolescents for Antipsychotic Drug Adverse Events. JAMA Psychiatry. January 14,2015.(E1-E3)
Please refer to Research Letter in the Packet
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Data Collection Methods
(NEISS-CADES) National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance system (2009-2011) for emergency room visits for adverse events in adolescents.
National Ambulatory Medical Care and National Hospital Ambulatory Medical Care Surveys (2009-2010) for outpatient prescriptions visits
Results reported about 6.6% of emergency room visits are related to atypical antipsychotics in children.
Unable to determine chronic disorders (metabolic side effects) with data.
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Idaho Medicaid reviewed the study to determine if a similar report could be obtained in the Idaho Medicaid pediatric population.
Limitations with data source collection
Available: Drug data and demographics
Problematic: Availability of collection of adverse events related to drug use.
Question/Comments?
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Narcotics: short-acting > long-acting
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Buprenorphine plus benzodiazepines Per Suboxone package insert: Suboxone sublingual film
should be prescribed with caution to patients taking benzodiazepines or other drugs that act on the CNS, regardless of whether these drugs are taken on the advice of a physician or are being abuse/misused.
How many oral buprenorphine patients are on concomitant benzodiazepines or controlled sedatives?
Are these concomitant medications prescribed by the buprenorphine prescriber?
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Atypical Antipsychotics without metabolic testing
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Abilify multiple dosage strengths
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Atypical Antipsychotics in children ≤ 6 years of age
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Prospective DUR Report History Errors:
• DD – drug-to-drug
• PG – drug to pregnancy
• TD – therapeutic duplication
• ER – early refill
• MC – drug-to-disease
Non-History Errors:
• PA – drug-to-age
• HD – high dose
• LD – low dose
• SX – drug-to-gender
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Prospective DUR Report Idaho Medicaid Program
ProDUR Message Report
March 2015
ProDUR ProDUR Message Message
Message Severity Count Amount
Drug To Drug 1 2,019 $616,589.22
2 17,070 $5,729,811.60
3 83,743 $17,016,279.58
9 8 $134.76
Drug To Gender 1 199 $31,266.48
2 2,084 $245,318.67
Drug To Known Disease 1 76,219 $11,160,515.45
2 263,457 $62,624,551.13
3 338,409 $76,792,225.01
Drug To Pregnancy 1 11 $44.00
2 9 $149.01
A 8 $98.05
B 58 $11,317.81
C 132 $14,170.94
D 13 $116.13
X 13 $441.45
Duplicate Therapy 0 131,074 $49,716,856.25
Min Max 0 33,546 $7,326,514.04
Too Soon Clinical 0 23,816 $8,002,753.47
ALL 971,888 $239,289,153.05
Total Number of Claims with Messages 237,585
Average ProDUR Message Per Claim 4.09
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DUR Spring Newsletter Clinical Alerts and Quarterly Trends
Brainstorm for new topics
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DUR Board Meeting April 16, 2015
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