Hypertrophic & Restrictive Cardiomyopathy:

Genetics, Imaging and Emerging Treatments in Adult and Pediatric Patients

Wednesday, March 13, 2013New York City

Introduction This program will focus on the diagnosis of hypertrophic and restrictive cardiomy-opathies (e.g. HCM, sarcoidosis, infiltrative diseases including iron overload and amyloidosis, mitochondrial disorders) based on imaging and modern genetics and the management of these conditions including novel therapeutics, catheter and sur-gical based interventions including cardiac replacement therapy. Lectures will be given by internationally recognized experts who will address the current clinical practice, use of standard and emerging treatments, and evolution of the field.

Target AudienceThis activity is designed for both adult and pediatric cardiologists, interventional cardiologists, pediatricians, internists, cardiac nurses, physician assistants, physical therapists, and other medical professionals involved in the evaluation, diagnosis and/or management of patients with hypertrophic and restrictive cardiomyopathy.

Learning Objectives• Demonstrate an understanding of how to identify the phenotype of HCM and

phenocopies that mimic HCM

• Delineate methods to risk stratify patients with HCM for SCD and role of AICD for primary prevention

• Discuss and understand the surgical and interventional approaches to hypertrophic obstructive cardiomyopathy (HOCM)

• Identify benefits of cardiac transplantation in HCM and RCM and recognize the limitations of LVAD therapy in this population

• Delineate the mechanisms of specific disease modifying therapies for specific restrictive cardiomyopathies and their appropriate use

• Outline emerging risk factors for SCD in HCM

• Describe the clinical utility and interpretation of genetic testing for patients with HCM and RCM

AccreditationThe College of Physicians and Surgeons of Columbia University is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA Credit Designation StatementThe College of Physicians and Surgeons designates this live activity for a maximum of 6.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses and physician assistants are encouraged to check with their accrediting organization to ensure they accept AMA PRA Category 1 Credits™.

SupportWe expect support for this program through grants from pharmaceutical and medical device companies.

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Program Agenda

7:00am – 8:00am Registration and Continental Breakfast

8:00am – 8:10am Welcome and Introduction – Mathew S. Maurer, MD & Hiroo Takayama, MD, PhD

8:10am – 8:30am Hemodynamic and Invasive Evaluation of HCM – Martin B. Leon, MD

8:30am – 8:50am Medical Therapy: What Really Works for HCM – Melana Yuzefpolskaya, MD

8:50am – 9:10am Echocardiography for HCM/RCM – Linda D. Gillam, MD, MPH

9:10am – 9:30am Cardiac MRI for Distinguishing Etiologies and Following Patients – Jonathan W. Weinsaft, MD

9:30am – 10:20am Case Presentations Moderator: Mathew S. Maurer, MD Case Presenters: Farhana Latif, MD, Takashi Nishimura, MD & Melana Yuzefpolskaya, MD Panelists: Emile A. Bacha, MD, Perry M. Elliott, MD, FRCP, FESC, FACC, John Lynn Jefferies, MD, MPH, FACC, FAAP, Susheel K. Kodali, MD, Martin B. Leon, MD & Hiroo Takayama, MD, PhD

10:20am – 10:30am Q&A Session

10:30am – 10:50am Break and Vendor Exhibits

10:50am – 11:10am Risk Markers for SCD: Do They Really Help in Selecting Patients for Primary Prevention with AICDs? – Jonathan T. Lu, MD, PhD

11:10am – 11:30am The Role of Genetic Testing in HCM/RCM – John Lynn Jefferies, MD, MPH, FACC, FAAP

11:30am – 11:50am Cardiac Replacement Therapy for HCM/RCM – Donna M. Mancini, MD

11:50am – 12:10pm Pediatric HCM: How it’s Different and How it’s Not – Linda J. Addonizio, MD

12:10pm – 12:30pm Evaluation of Appropriate Recreational Activities for Children with HCM – Warren A. Zuckerman, MD

12:30pm – 12:50pm Q&A Session

12:50pm – 1:50pm Lunch and Vendor Exhibits

1:50pm – 2:10pm Medical Treatment of Infiltrative/Restrictive Cardiomyopathies – Perry M. Elliott, MD, FRCP, FESC, FACC

2:10pm – 2:30pm Nuclear Cardiology’s Role in the Evaluation of Patients with HCM/RCM – Sabahat Bokhari, MD

2:30pm – 2:50pm Treatment of Cardiac Iron Overload: Emerging Therapies – Sujit Sheth, MD

2:50pm – 3:10pm Cardiac Amyloidosis: A Treatable Condition? – Mathew S. Maurer, MD

3:10pm – 3:30pm Mitochondrial Disorders in the Heart – Perry M. Elliott, MD, FRCP, FESC, FACC

3:30pm – 3:50pm HCMA: Where Did it Start and What are They Doing? – Lisa Salberg, CEO and Founder, HCMA

3:50pm – 4:10pm Q&A Session and Closing Remarks

Program Directors

Mathew S. Maurer, MD Associate Professor of Clinical Medicine Columbia University College of Physicians and Surgeons Co-Director, The HCM Program NewYork-Presbyterian Hospital/ Columbia University Medical Center

Hiroo Takayama, MD, PhD Assistant Professor of Surgery Division of Cardiothoracic Surgery Columbia University College of Physicians and Surgeons Director, Acute Circulatory Support Program Co-Director, The HCM Program NewYork-Presbyterian Hospital/ Columbia University Medical Center

Melana Yuzefpolskaya, MD Instructor of Clinical Medicine Department of Medicine, Division of Cardiology Columbia University College of Physicians and Surgeons NewYork-Presbyterian Hospital/ Columbia University Medical Center

Program Faculty

Linda J. Addonizio, MD Professor of Pediatrics Columbia University College of Physicians and Surgeons Director, Program for Pediatric Cardiomyopathy, Heart Failure and Transplantation NewYork-Presbyterian Morgan Stanley Children’s Hospital/Columbia University Medical Center

Emile A. Bacha, MD Professor of Surgery Columbia University College of Physicians and Surgeons Chief, Congenital and Pediatric Cardiac Surgery Chief, Division of Cardiothoracic Surgery NewYork-Presbyterian Morgan Stanley Children’s Hospital/Columbia University Medical Center

Sabahat Bokhari, MD Assistant Professor of Medicine Department of Medicine, Division of Cardiology Columbia University College of Physicians and Surgeons Director of Nuclear Cardiology NewYork-Presbyterian Hospital/ Columbia University Medical Center

Perry M. Elliott, MD, FRCP, FESC, FACC Professor of Cardiovascular Medicine Institute of Cardiovascular Science University College London

Linda D. Gillam, MD, MPH Dorothy and Lloyd Huck Chair Department of Cardiovascular Medicine Atlantic Health System (Morristown Medical Center)

John Lynn Jefferies, MD, MPH, FACC, FAAP Associate Professor, Pediatric Cardiology and Adult Cardiovascular Diseases Director, Cardiomyopathy, Advanced Heart Failure, and Ventricular Assist Device Programs Co-Director, Cardiovascular Genetics The Heart Institute Cincinnati Children’s Hospital

Susheel K. Kodali, MD Assistant Professor of Clinical Medicine Columbia University College of Physicians and Surgeons Director, Interventional Cardiology Fellowship Program Co-Director, Heart Valve Center NewYork-Presbyterian Hospital/ Columbia University Medical Center

Farhana Latif, MD Assistant Professor of Clinical Medicine Columbia University College of Physicians and Surgeons NewYork-Presbyterian Hospital/ Columbia University Medical Center

Faculty Listing

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Faculty Listing

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Martin B. Leon, MD Professor of Medicine Columbia University College of Physicians and Surgeons Director, Center for Interventional Vascular Therapy (CIVT) Director of the Cardiac Catheterization Laboratories NewYork-Presbyterian Hospital/ Columbia University Medical Center Founder and Chairman Emeritus Cardiovascular Research Foundation

Jonathan T. Lu, MD, PhD Assistant Professor of Medicine Division of Cardiology, Section of Electrophysiology Columbia University College of Physicians and Surgeons NewYork-Presbyterian Hospital/ Columbia University Medical Center

Donna M. Mancini, MD Professor of Medicine Sudhir Choudhrie Professor of Cardiology Columbia University College of Physicians and Surgeons Medical Director, Center for Advanced Cardiac Care NewYork-Presbyterian Hospital/ Columbia University Medical Center

Takashi Nishimura, MD Clinical Fellow Department of Surgery Columbia University College of Physicians and Surgeons NewYork-Presbyterian Hospital/ Columbia University Medical Center

Lisa Salberg CEO and Founder The Hypertrophic Cardiomyopathy Association

Sujit Sheth, MD Associate Professor of Pediatrics Weill Cornell Medical College Chief, Division of Pediatric Hematology and Oncology NewYork-Presbyterian Hospital/ Weill Cornell Medical Center

Jonathan W. Weinsaft, MD Associate Professor of Medicine Weill Cornell Medical College Director, Cardiac MRI Program NewYork-Presbyterian Hospital/ Weill Cornell Medical Center

Warren A. Zuckerman, MD Assistant Professor of Clinical Pediatrics Program for Pediatric Cardiomyopathy, Heart Failure and Transplantation Columbia University College of Physicians and Surgeons NewYork-Presbyterian Morgan Stanley Children’s Hospital/Columbia University Medical Center

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Contact InformationColumbia University Medical Center Department of Surgery, External Affairs 400 Kelby Street, 11th Floor Fort Lee, NJ 07024

Program Administrator

Deborah Schwarz, RPA, CIBE Executive Director and Chief Communications Officer Columbia University Medical Center Department of Surgery, External Affairs

Program Coordinator Stephanie Scheeler, CMP Special Events Coordinator Columbia University Medical Center Department of Surgery, External Affairs Phone: 201.346.7003 Fax: 201.346.7011 E-mail: sas2258@columbia.edu

Registration FeesPhysicians requesting CME credit – $105 Physicians not requesting CME credit – $75

Non-physicians, nurses, and other clinical staff requesting CME credit – $80 Non-physicians, nurses, and other clinical staff not requesting CME credit – $50

Residents and fellows (no CME credit will be awarded) – $25

Fees include program lectures, course materials, and meals. A confirmation e-mail will be sent upon receipt of registration and payment.

Payment MethodOnline: To make a credit card payment, please register online at: www.ColumbiaSurgeryCME.org and select this course. For security purposes, credit card payments cannot be accepted in the mail or by phone. American Express, Discover, MasterCard, and Visa are accepted.

By Mail: Please complete the attached registration form and mail together with full payment to:

Columbia University Medical Center Department of Surgery, External Affairs 400 Kelby Street, 11th Floor Fort Lee, NJ 07024 ATTN: HCM/RCM Course

Enclose a check or money order made payable to Columbia University Department of Surgery. Checks must be drawn in U.S. dollars on a U.S. bank.

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Program LocationColumbia University Medical Center Bard Hall 50 Haven Avenue New York, NY 10032

Local Area HotelsFor a listing of local area hotels, please visit: www.ColumbiaSurgeryCME.org and select this course.

Parking Parking is available at the NewYork-Presbyterian Hospital/Columbia University Medical Center parking lot, located on the southwest corner of Fort Washington Avenue and West 165th Street. Parking is not included in the registration fee for this course.

SubwayTake the 1, A, C lines to 168 Street- Washington Heights/Broadway.

Registration Please register me for the continuing medical education program entitled:

Hypertrophic & Restrictive Cardiomyopathy: Genetics, Imaging and Emerging Treatments in Adult and Pediatric Patients

Wednesday, March 13, 2013

m Physicians requesting CME credit – $105 m Physicians not requesting CME credit – $75 m Non-physicians, nurses, and other clinical staff requesting CME credit – $80 m Non-physicians, nurses, and other clinical staff not requesting CME credit – $50 m Residents and fellows (no CME credit will be awarded) – $25

Space is limited, early registration is highly encouraged.

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Please Note: Registration is limited and will be handled on a first-come, first-served basis. Telephone registrations and/or cancellations are not accepted. Refund of registration fee, less a $25 administrative charge, will be made if written notice of cancellation is received by Wednesday, February 27, 2013. No refunds can be made thereafter.

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