Human Endocrine Physiology

February 13, 2014

Reprise: Hypothalamic-Pituitary SystemsThe Thyroid AxisThe Adrenal Axis

Thyroid Physiology

in Pregnancy

•Importance for fetal development•Changes in maternal thyroid stimulation•Iodine deficiency

Balance Between TSH and hCG in Pregnancy

Maternal iodine important

TSHT4

+

-

Glycoprotein family of hormones

(hCG)

(TSH receptor)(hCG receptor)

TSH

T4+-

hCG+

Maternal iodine important

Iodine

T4*,T3

***Only T4 crosses the BBB

DI

***