HuBio 546 GI/Liver Gross Lab Page 1

Gastric Cancer

A. Benign gastric ulcer.

B. Malignant gastric ulcer.

Note: the benign and malignant ulcers on slides A & B are remarkably similar, both showing small,

circumscribed ulcers with radiating folds and no mass lesions. These are so-called "benign" features

that prove the important point that gross features are not diagnostic in gastric ulcers. Biopsy with

histologic examination is mandatory.

HuBio 546 GI/Liver Gross Lab Page 2

Gastric Cancer

C. Leather bottle stomach of linitis plastica-type gastric adenocarcinoma.

D. Gross cross section of linitis plastica gastric adenocarcinoma showing wall thickening and diffuse

gross infiltration by tumor into all layers of the gastric wall, including the mucosa, submucosa,

muscularis propria (white streaks) and subserosa.

HuBio 546 GI/Liver Gross Lab Page 3

Gastric Cancer

E. Mass lesion/polypoid and ulcerated gastric adenocarcinoma, seen in this en face mucosal or

surface view.

F. Gross cross section of the mass lesion/polypoid and ulcerated gastric adenocarcinoma seen in

slide E above. Note the transmural invasion of the tumor--important for staging.