hpv and cervical cancer neuronal noise statistics applied to ......surgery for spinal tumours.-15...

Biomedicine. springer.com/NEWSonline

14

F. Borruto, University of Verona, Italy; M. De Ridder, Free University of Brussels, Belgium (Eds)

HPV and Cervical CancerAchievements in Prevention and Future Prospects

This book is meant to provide a complete over-view of the research of HPV and its connection to cervical cancer.

Features 7 Provides overview of HPV research from discovery to the present day 7 Examines the process of HPV infection to oncogenesis 7 Ex-plores the effects of HPV vaccination

Contents Preface.- The epidemiology of cervical cancer.- Human Papillomavirus And Cervical Cancer: Overview.- Prevention of HPV Associated Diseases in the United States.- Immunogenicity and efficacy of, and most effective and just imple-mentation strategies for human papillomavirus vaccines – an overview.- The Immunobiology Of Human Papillomavirus Associated Oncogenesis.- HPV and Therapeutic Vaccines: Where are we in 2010?.- Infection and cervical cancer: an old fact with a recent solution.- Colposcopic Appearance Of Hpv Infection.- Index.

Fields of interestCancer Research; Pharmacology/Toxicology

Target groupsResearch

Discount group P

Due February 2012

2012. X, 200 p. Hardcover7 approx. $189.00ISBN 978-1-4614-1987-7

9

T. J. Cleophas, A. H. Zwinderman, European Interuniversity College Pharmaceutical Medicine, Lyon, France

Statistics Applied to Clinical StudiesContents Preface. Foreword.-1 Hypotheses, data, strati-fication.-2 The analysis of efficacy data.-3 The analyis of safety data.-4 Log likelihood ratio tests for safety data analysis.-5 Equivalence testing.- 6 Statistical power and sample size.-7 Interim analyses.-8 Clinical trials are often false positive.-9 Multiple statistical inferences.-10 The interpretation of the p-values.-11 Research data closer to expectation than compatible with random sampling.-12 Statistical tables for testing data closer to expectation than compatible with random sampling.-13 Dispersion issues.-14 Linear regression, basic approach.-15 Linear regression for assessing precision, confounding, interaction, basic approach.-16 Curvilinear regression.-17 Logistic and cox regression, markow models, regression with laplace transformations.-18 Regression modeling for improved precision.-19 Post-hoc analysis in clinical trials, a case for logistic regression analysis.-20 Multistage regres-sion.-21 Categorical data.-22 Missing data.-23 Poisson regression for event analysis.-24 More on non linear relationships, splines.-25 Multivariate modeling.-26 Bhattacharya modeling.-27 Trend-testing.-28 Confounding.-29 Propensity score matching.-30 Interaction.-31 Time-dependent fac-tor analysis.-32 Meta-analysis, basic approach.-33 Meta-analysis, review and update ofmethodolo-gies.-34 Meta-regression.-35 Crossover studies with continuous variables.-36 Crossover studies with binary responses. [...]

Fields of interestBiomedicine general; Laboratory Medicine; Stati-stics, general


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5th ed. 2012. XXVI, 743 p. 178 illus., 44 in color. Hardcover7 approx. $239.00ISBN 978-94-007-2862-2

9

A. Destexhe, M. Rudolph-Lilith, CNRS, Gif sur Yvette, France

Neuronal NoiseNeuronal Noise combines experimental, theoreti-cal and computational results to show how noise is inherent to neuronal activity, and how noise can be important for neuronal computations.

Features 7 Neuronal Noise combines experimental, theoretical and computational results to show how noise is inherent to neuronal activity 7 The book covers many aspects of noise in neurons, with an emphasis on the largest source of noise: synaptic noise 7 Provides students and young researchers with an overview of the important methods and concepts that have emerged from research in this area 7 The book covers many aspects of noise in neurons, with an emphasis on the largest source of noise: synaptic noise 7 Provides students and young researchers with an overview of the im-portant methods and concepts that have emerged from research in this area 7 Provides students and young researchers with an overview of the im-portant methods and concepts that have emerged from research in this area

Contents 1 Introduction.- 2 Basics.- 3 Synaptic noise.- 4 Models of synaptic noise.- 5 Integrative properties in the presence of noise6 Recreating synaptic noise using dynamic-clamp.- 7 The mathematics of sy-naptic noise.- 8 Analyzing synaptic noise.- 9 Case studies.- 10 Conclusions and perspectives A Nu-merical integration of stochastic differential equa-tions.- B Distributed Generator Algorithm.- C The Fokker-Planck formalism.- D The RT-NEURON interface for dynamic-clamp.- References.- Index.

Fields of interestNeurosciences; Neurobiology


Discount group P

Due January 2012

2012. XVIII, 462 p. 203 illus., 1 in color. (Springer Series in Computational Neuroscience, Volume 8) Hardcover7 $209.00ISBN 978-0-387-79019-0

9

www.springer.com/978-1-4614-1987-7www.springer.com/978-94-007-2862-2www.springer.com/978-0-387-79019-0

News 11/2011 Biomedicine.

15

K. Groschner, Karl Frazens University, Graz, Austria; W. F. Graier, Medical University, Graz, Austria; C. Romanin, Linz, Austria (Eds)

Store-operated Ca2+ entry (SOCE) pathwaysEmerging signaling concepts in human (patho)physiology

Contents Preface (C. Romanin, W. F. Graier, K. Groschner).- SECTION 1: SOCE – Fundamental mechanistic concepts.- Introduction (J. W. Putney).- 1.1 The STIM-Orai pathway.- Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura).- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan).- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin).- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem).- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu).- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca).- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: Endogenous messen-gers and mediators (V. M. Bolotina).- SECTION 2: SOCE – Crosstalk between organelle and cellular compartments.- Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh).- 2.1 New aspects of the contribution of ER to SOCE regulation. [...]

Fields of interestMolecular Medicine; Cell Biology; Human Phy-siology


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2012. XII, 500 p. 56 illus., 32 in color. With online files/update. Hardcover7 $209.00ISBN 978-3-7091-0961-8

9

M. Hayat, Kean University, NJ, USA (Ed.)

Stem Cells and Cancer Stem Cells, Volume 4Therapeutic Applications in Disease and Injury

Contents I. Molecular genetic.-1 Neural stem/progeni-tor cell proliferation and differentiation: role of sonic hedgehog and wingless/int-1 proteins.-2 Sensitivity of hematopoietic and leukemic stem cells to hoxa gene levels.-3. Maintenance of neural stem cells in the brain: role of notch signaling.-4 Maintenance of hematopoiesis: role of early b cell factor 2 matthias kieslinger.-5 Differentia-tion of periodontal stem/progenitor cells: roles of tgf-β1.-6 Induced pluripotent stem cells from human extra-embryonic amnion cells: role of dna methylation in mainting stemness.-7 Smooth muscle cell differentiation from embryonic stem cells: role of hdac7 and pdgf-bb.-8 Adult neural stem cells; identity and regulation. II. Regenerative Medicine.-9 Tendon injury: role of differentiation of aduilt and embryonic derived stem cells.-10 The potential of stem cells and tissue engineered scaf-folds for repair of the central nervous system.-11 Improving the efficacy of diabetes mellitus treat-ment by combining cell replacement therapy with immune correction.-12 Induced pluripotent stem cell production and characterization: an overview of somatic cell reprogramming.-13 Proliferation of bone marrow-derived human mesenchymal stem cells: role of enamel matrix proteins.-14 Pluripo-tent cell-derived glial precursor cells for the deli-very of therapeutic proteins to the central nervous system.-15 Cellularized scaffolds: new clothes for cardiac regenerative medicine. [...]

Fields of interestCancer Research; Oncology; Stem Cells


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2012. XII, 366 p. 44 illus., 32 in color. (Stem Cells and Cancer Stem Cells, Volume 4) Hardcover7 $209.00ISBN 978-94-007-2827-1

9

M. Hayat, Kean University, NJ, USA (Ed.)

Tumors of the Central Nervous System, Volume 6Spinal Tumors (Part 1)

Contents 1 General introduction.-2 Pediatric mixed glio-neuronal tumors in the spinal cord.-3 Intradural spinal tumors: classification, symptoms, and radio-logical features.-4 Non-dysraphic intradural spinal cord lipoma: management guidelines.-5 Malignant astrocytomas of the spinal cord: clinicopathologic parameters.-6 Spinal epidural angiolipoma. I Di-agnosis.-7 Spinal cord tumor oligodendroglioma: diagnosis.-8 Primary spinal oligodendroglioma: diagnosis, outcome, and prognosis.-9 Pilomyxoid astrocytoma of the spinal cord with cerebrospinal fluid and peritoneal metastasis.-10 Intraspinal oncocytic adrenocortical adenoma: diagnosis.-11 Chordomas of the clivus and upper cervical spine. Imaging.-12 Spinal teratoid/ rhabdoid tumor: use of diffusion - weighted imaging for diagnosis.-13 Gangliogliomas of the spinal cord: neuroimaging correlations with pathology, controversies in pathological diagnosis, and prognosis. Therapy.-14 Surgery for spinal tumours.-15 Resection of spinal meningioma: postoperative focal hyperemia.-16 Spinal cord hemangioblastomas: surgical manage-ment.-17 Spinal radiosurgery: delayed radiation-induced myelopathy.-18 Metastatic spine disease: indications, timing, and outcomes for surgery and radiation therapy.-19 Sequence of surgery, radiotherapy, and stereotactic radiosurgery in the treatment of metastatic spine disease: effects on wound healing.-20 Treatment of spinal tumors with cyberknife stereotactic radiotherapy.-21 Re-current spinal cord cystic astrocytomas: treatment with rhenium-186 intracavitary radiation. [...]

Fields of interestCancer Research; Laboratory Medicine; Diag-nostic Radiology


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2012. XXXII, 204 p. 64 illus., 26 in color. (Tumors of the Central Nervous System, Volume 6) Hardcover7 $189.00ISBN 978-94-007-2865-3

9



16

M. v. Itzstein, Griffith University, QLD, Australia (Ed.)

Influenza Virus Sialidase – A Drug Discovery TargetInfluenza continues to be an ongoing problem de-spite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interac-tions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented.

Features 7 Covers all relevant aspects of anti-influenza virus drug discovery 7 Contributions by inter-national leading scientists 7 A valuable source of information for researchers, clinicians and the pharmaceutical industry

Contents Influenza Virus Virology.- Investigating the inter-action between influenza and sialic acid – making and breaking the link.- Enzymology of Influenza Virus Sialidase.- Influenza Virus Sialidase and Structure-Based Drug Design.- The Development of Carbohydrate-based Influenza Virus Sialidase Inhibitors.- The Development of Non-carbohyd-rate-based Influenza Virus Sialidase Inhibitors.- Clinical Experience with Influenza Virus Sialidase Inhibitors.- Resistance Development to Influenza Virus Sialidase Inhibitors.

Fields of interestPharmacology/Toxicology; Infectious Diseases; Virology


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2012. IX, 178 p. 58 illus., 21 in color. (Milestones in Drug Therapy) Hardcover7 $189.00ISBN 978-3-7643-8926-0

9

Y. Karamanos, Université d‘Artois, Arras, France (Ed.)

Expression Profiling in NeuroscienceFeatures 7 Provides the most commonly used approaches to gene and protein expression profiling in the field of neuroscience 7 Examines the techniques in thorough detail in order to create lab-ready instruction 7 Features clear-cut advice and guidance from expert researchers in the field

Contents DNA Microarrays for Gene Expression Analysis in Brain Tissue and Cell Lines.- Gene Expression Profiling Using the Terminal Continuation (TC) RNA Amplification Method for Small Input Samp-les in Neuroscience.- Expression Profiling In Brain Disorders.- Endothelial Cell Heterogeneity of Blood-Brain Barrier Gene Expression: Analysis by LCM/qRT-PCR.- Gene Expression Profiling Using 3’ Digital Tag Approach.- Sharing Expression Profiling Data with Gemma.- Two-Dimensional Protein Analysis of Neural Stem Cells.- iTRAQ Proteomics Profiling of Regulatory Proteins During Oligodendrocyte Differentiation.- Protein Profiling of the Brain: Proteomics of Isolated Tis-sues and Cells.- The Proteome of Brain Capillary Endothelial Cells: Towards a Molecular Cha-racterization of an In Vitro Blood-Brain Barrier Model.- MALDI Imaging Technology Application in Neurosciences: From History to Perspectives.- Profiling of HIV Proteins in Cerebrospinal Fluid.- Proteomic Profiling of Cerebrospinal Fluid.- New Nanotechnology Applications in Single Cell Ana-lysis: Why and How.

Fields of interestNeurosciences; Proteomics

Target groupsProfessional/practitioner

Discount group P

Due January 2012

2012. XII, 308 p. 55 illus., 43 in color. (Neuromethods, Volume 64) Hardcover7 $119.00ISBN 978-1-61779-447-6

9

E. Kotb, Zagazig University, Egypt

Fibrinolytic Bacterial Enzymes with Thrombolytic ActivityStress, high blood pressure, smoking, polluti-on, fast foods, overweight, excessive travelling, surgery, less movement are common features in our modern life. These features are risky for blood clotting disorders. According to WHO, over 29% of the total mortalities worldwide are due to thrombosis. By the year, 2020 cardiovascular di-seases (CVDs) may cause an estimated 25 million deaths per year, thus antithrombotic therapy is of great interest. The available thrombolytic agents such as urokinase are highly expensive, antigenic, quite unspecific, pyretogenic and hemorrhagenic. Therefore, the production of fibrinolysing enzy-mes, which rapidly dissolute thrombi within the vascular tree, without the detriments by microor-ganisms, as described in this book, is the desirable aim of today’s research.

Features 7 Integrated practical and theoretical trends 7 Describes fibrinolytic microbial enzymes for clinical applications 7 Provides an outlook to future research

Fields of interestMedical Microbiology; Hematology; Cardiology


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2012. XI, 97 p. 15 illus., 6 in color. (SpringerBriefs in Microbiology) Softcover7 $49.95ISBN 978-3-642-24979-2

9



17

M. R. Kreutz, Leibniz Institute for Neurobiology, Magdeburg, Germany; C. Sala, Consiglio Nazionale delle Richerche, Milano, Italy (Eds)

Synaptic PlasticityDynamics, Development and Disease

Contents Preface Michael R. Kreutz, Carlo Sala.- Molecular organization of the pre- and postsynaptic scaffold: 1. Uli Thomas, Stephan Sigrist: Glutamate recep-tors in synaptic assembly and plasticity – case studies on fly NMJs.- 2. Chiara Verpelli, Michael J. Schmeisser, Carlo Sala, Tobias M. Boeckers: Scaffold proteins at the Postsynaptic Density.- 3. Laurent Fagni: Diversity of metabotropic glut-amate receptor interacting proteins and patho-physiological functions.- 4. Peter Penzes, Igor Rafalovich: Regulation of the actin cytoskeleton in dendritic spines.- 5. Olena Bukalo, Alexander Dityatev: Synaptic cell adhesion molecules.- Mo-lecular dynamics of the synapse: 6. Shigeo Okabe: Molecular dynamics of excitatory synapses.- 7. Renato Frischknecht, Eckart D. Gundelfinger: The brain‘s extracellular matrix and its role in synaptic plasticity.- 8. Robert van den Berg, Casper C. Hoo-genraad: Molecular motors in cargo trafficking and synapse assembly.- 9. Martin Heine: Surface traffic in synaptic membranes.- 10. Bong-Kiun Kaang, Jun-Hyeok Choi: Synaptic protein degra-dation in memory reorganization.- 11. Madhav Sukumaran, Andrew C. Penn, Ingo H. Greger: AMPA receptor assembly – atomic determinants and built-in modulators.- 12. Malgorzata Urbans-ka, Lukasz Swiech, Jacek Jaworski: Developmental plasticity of the dendritic compartment: focus on the cytoskeleton.- 13. Stefan Kindler, Hans-Jürgen Kreienkamp: Dendritic mRNA targeting and translation.- 14. Mirko Santello, Corrado Calì, Paola Bezzi: Gliotransmission and the Tripartite Synapse. [...]

Fields of interestNeurosciences; Neurology; Neurobiology


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2012. Approx. 600 p. 120 illus., 20 in color. (Advances in Experimental Medicine and Biology, Volume 970) Hardcover7 $239.00ISBN 978-3-7091-0931-1

9

Z. D. Luo, University of California Irvine Medical Center, Orange, CA, USA (Ed.)

Pain ResearchMethods and Protocols

Contents Advancements in Pain Research.- Genomic Methods for Clinical and Translational Pain Research.- Two-Dimensional Gel Electropho-resis: Discovering Neuropathic Pain-Associated Synaptic Biomarkers in Spinal Cord Dorsal Horn.- Whole-Cell Patch-Clamp Recordings on Spinal Cord Slices.- Whole-Cell Recording in Isolated Primary Sensory Neurons.- Indwelling Supradu-ral Catheters for Induction of Facial Allodynia: Surgical Procedures, Application of Inflammatory Stimuli, and Behavioral Testing.- An Experimen-tal Model of Headache-Related Pain.- A Rodent Model of Trigeminal Neuralgia.- New Models of Experimental Parotitis and Parotid Gland Distension in Rats.- A Rat Pain Model of Facial Cancer.- Orofacial Pain Models and Behavior Assessment.- Unilateral T13 and L1 Dorsal Root Avulsion: Methods for a Novel Model of Central Neuropathic Pain.- A Lumbosacral Ventral Root Avulsion Injury and Repair Model for Studies of Neuropathic Pain in Rats.- A Rat Chronic Pain Model of Spinal Cord Contusion Injury.- The Spared Nerve Injury Model of Neuropathic Pain.- A New Rat Pain Model of Thrombus-Induced Ischemia.- Rat Models of Pancreatitis Pain.- The Monosodium Iodoacetate Model of Osteoarthritis Pain in The Rat.- K/BxN Serum Transfer Arthritis as a Model of Inflammatory Joint Pain.- A New Rat Model of Bone Cancer Pain.- Exposure of the Dorsal Root Ganglion to Pulsed Radiofrequency Current in a Neuropathic Pain Model of Periphe-ral Nerve Injury.

Fields of interestMolecular Medicine; Pain Medicine


Discount group P

Due January 2012

2nded. 2012. XIX, 306 p. 66 illus., 4 in color. (Methods in Molecular Biology, Volume 851) Hardcover7 approx. $119.00ISBN 978-1-61779-560-2

9

A. Morozov, National Institutes of Health, Bethesda, MD, USA (Ed.)

Controlled Genetic ManipulationsThe current demand for the development of techniques for controlled genetic manipulations is driven by the anatomical and physiological complexity of the brain and by the need for expe-rimental models that can address this complexity through selective manipulation of defined compo-nents of the system: specific neuronal populations or selected synapses.

Features 7 Provides both basic technical information and examples of creative implementation 7 Supplies readers with the details needed to bring these techniques to their own labs 7 Features key tips from the experts on how best to avoid common pitfalls

Contents Regulation of Cre Recombinase: Use of Ligand-Regulated and Dimerizable Cre for Transgenesis.- Genetic Manipulations Using Cre and Mutant loxP Sites.- Using Recombinant Adeno-Associated Viral Vectors for Gene Expression in the Brain.- Using Lentiviral Vectors as Delivery Vehicles for Gene Therapy.- Targeting Neurological Disease with siRNA.- In Utero Electroporation for Cellular Transgenesis in the Developing Mammalian Forebrain.- Single-Cell Electroporation of siRNA in Primary Neuronal Cultures.- Development and Application of Membrane-Tethered Toxins for Genetic Analyses of Neuronal Circuits.- Genetic Methods for Anatomical Analysis of Neuronal Circuits.- Functional Circuitry Analysis in Ro-dents Using Neurotoxins/Immunotoxins.- Analy-sis of Neuronal Circuits with Optogenetics.

Fields of interestNeurosciences; Human Genetics


Discount group P

Due January 2012

2012. XIII, 296 p. 47 illus., 27 in color. (Neuromethods, Volume 65) Hardcover7 $119.00ISBN 978-1-61779-532-9

9



18

J. Peccoud, Virginia Bioinformatics Institute, Blacksburg, VA, USA (Ed.)

Gene SynthesisMethods and Protocols

Contents Building Block Synthesis using the Polymerase Chain Assembly (PCA) Method.-Oligonucleotide Assembly in Yeast to Produce Synthetic DNA Fragments.-TopDown Real-Time Gene Synthesis.-De novo DNA Synthesis using Single-molecule PCR.-SLIC: A Method for Sequence and Ligation Independent Cloning.-Assembly of Standardized DNA Parts Using BioBrick Ends in E. coli.-Assembling DNA Fragments by USER Fusion.-Fusion PCR via Novel Overlap Sequences.-Using Recombineering to Generate Point Mutations: the Oligonucleotide-based “Hit &Fix” Method.-Using Recombineering to Generate Point Mutations: galK-Based Positive-Negative Selection Method.-Assembling Large DNA Segments in Yeast.-Recursive Construction of Perfect DNA Molecules and Libraries from Imperfect Oligonucleotides.-Cloning Whole Bacterial Genomes in Yeast.-Production of Infectious Poliovirus from Synthetic Viral Genomes.-In Silico Design of Functional DNA Constructs.-Using DNAWorks in Designing Oligonucleotides for PCR-Based Gene Synthesis.-De Novo Gene Synthesis Design Using TmPrime Software.-Design-A-Gene with GeneDesign.-Leading a Successful iGEM Team .-The Build-a-Genome Course.-DNA Synthesis Security.

Fields of interestHuman Genetics; Genetic Engineering


Discount group P

Due February 2012

2012. XV, 320 p. 77 illus., 42 in color. (Methods in Molecular Biology, Volume 852) Hardcover7 $139.00ISBN 978-1-61779-563-3

9

D. W. Pfaff, Rockefeller University, New York, NY, USA (Ed.)

Neuroscience in the 21st CenturyBasic and Clinical

Contents BASIC.- Biophysics.- Development.- Neuroanato-my, Cell, Biology.- Sensory Systems (neuroanato-my and physiology).- Motor Control (neuroanato-my and physiology).- Neurophysiology of specific CNS regions.- Neurochemistry, Neuropharmaco-logy.- Neuroendocrinology.- Regulation of natural behaviors.- Cognitive Neuroscience.- Computati-onal neuroscience.- CLINICAL.- Developmental disorders.- Pain.- Neuroimmune disorders.- Ad-dictive disorders.- Degenerative diseases.- Gender identity issues.- Psychiatric disorders.<

Fields of interestNeurosciences; Neurobiology; Neurology


Discount group P

Due August 2012

Print

2012. 1200 p. (In 2 volumes, not available separately) 7 $679.00ISBN 978-1-4614-1996-9

9 eReference

2012. 7 $679.00ISBN 978-1-4614-1997-6

9 Print + eReference

2012. 1200 p. (In 2 volumes, not available separately)7 $849.00ISBN 978-1-4614-1998-3

9

A. Prokop, Vanderbilt University, Nashville, TN, USA; S. Michelson, Genomic Health Inc, Redwood, CA, USA

Systems Biology in Biotech & PharmaA Changing Paradigm

Features 7 Numerous step-by-step tutorials help the reader to learn quickly 7 Outline of key tech-nologies and tools needed for the development of Systems Biology 7 Computational Systems Bio-logy in Health and Disease 7 The use of Systems Biology for identifying drug targets

Contents Abstract.- 1 Introduction: Discovery & Deve-lopment - New Facet Of Industry, New Tools And Lead Optimization: 1.1 Scope And Content Of This Review.- 2 Discovery: Use Of Systems Biology For Identifying Targets.- 3 Integrative Systems Biology I - Biochemistry: Phase I Lead Discovery & Molecular Interactions.- 4 Integ-rative Systems Biology Ii - Molecular Biology: Phase 2 Lead Discovery & In Silico Screening.- 5. Discovery: Computational Systems Biology (Csb) In Health & And Disease I.- 6 Development: In Vivo Pharmacology - Systems Biology In Health & Disease Ii.- 7 Development: Pharmacokinetics – Systems Biology In Health & Disease Iii.- 8 De-velopment: Multiscale Csb – Simulation Tools.- 9 Development: Drug Formulation & Delivery.- 10 Development: Preclinical Model Based Drug Development.- 11 Systems Biology: Impact On Pharma And Biotech.- 12 Acknowledgment.- 13 Bibliography.

Fields of interestBiomedicine general; Biotechnology; Applied Microbiology


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2012. XVI, 133 p. 16 illus. in color. (SpringerBriefs in Pharmaceutical Science & Drug Development, Volume) Softcover7 $49.95ISBN 978-94-007-2848-6

9

www.springer.com/978-1-61779-563-3www.springer.com/978-1-4614-1996-9www.springer.com/978-1-4614-1997-6www.springer.com/978-1-4614-1998-3www.springer.com/978-94-007-2848-6


19

F. Rahimi, Australian National University, Canberra, ACT, Australia; G. Bitan, University of California at Los Angeles, CA, USA (Eds)

Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative DiseasesContents 1. Overview of Fibrillar and Oligomeric Assem-blies of Amyloidogenic Proteins.- 2. Pathologic Lesions in Alzheimer disease and Other Neuro-degenerative Diseases—Cellular and Molecular Components.- 3. Preparation and Structural Cha-racterization of Pre-fibrillar Assemblies of Amylo-idogenic Proteins.- 4. Biological Targeting and Ac-tivity of Pre-fibrillar Aβ Assemblies.- 5. The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s disease.- 6. Oligomers of α-Synuclein in the Pathogenesis of Parkinson’s Disease.- 7. Cytotoxic Mechanisms of Islet Amyloid Polypepti-de in the Pathogenesis of Type-2 Diabetes Mellitus (T2DM).- 8. Protein Misfolding and Toxicity in Amyotrophic Lateral Sclerosis.- 9. Structural Studies of Prion Proteins and Prions.- 10. Role of Prion Protein Oligomers in the Pathogenesis of Transmissible Spongiform Encephalopathies.- 11. When More Is Not Better: Expanded Polyglutami-ne Domains in Neurodegenerative Disease.- 12. Protein Misfolding and Toxicity in Dialysis-Rela-ted Amyloidosis.- 13. Transthyretin Aggregation and Toxicity.- 14. Strategies for Inhibiting Protein Aggregation: Therapeutic Approaches to Protein-Aggregation Diseases.

Fields of interestBiomedicine general; Protein Science; Protein Structure


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2012. XVII, 593 p. 81 illus., 37 in color. Hardcover7 $209.00ISBN 978-94-007-2773-1

9

T. Rőszer, Spanish National Cardiovascular Research Center, Madrid, Spain

The Biology of Subcellular Nitric OxideThis book fills in a gap in the NO literature.

Features 7 Fills a gap in NO biology-related litera-ture 7 Topics discussed have general biological relevance Interdisciplinary summary on recent advance on NO cellular biology 7 Chapter summaries and illustrations help rapid understan-ding of complex interactions 7 Can be used as a reference in scientific papers 7 Can be used as a lecture book

Contents Foreword.- Preface.- Part I General Concepts.- Introduction Part II Nitric Oxide Synthesis in Prokaryote Cells.- 2 Nitric Oxide is a Bioproduct In Prokaryotes.- Part III Nitric Oxide Synthesis in Plant Organelles.- 3 Nitric Oxide Synthesis in the Chloroplast.- 4 NO Synthesis in Leaf Peroxisomes And Plant-Type Mitochondria.- Part IV At the Edge of the Plant and Animal Kingdom.- 5 NO Synthesis iIn Subcellular Compartments of Fungi.- Part V Nitric Oxide Synthesis in Animal Cells.- 6 Harboring of NOS to the Cell Membrane.- 7 The Golgi System Contributes to NO Homeostasis.- 8 Phagosomal And Lysosomal NO Synthesis.- 9 NO Synthesis and Cell Locomotion.- 10 Nitric Oxide Synthesis in the Mitochondria of Animal Cells.- 11 Peroxisomes: Where NOS Rests In Peace?.- 12 Subcellular Redistribution of NOS.- Appendix.- Abbreviations.- Glossary.- Image Information.- Subject Index.

Fields of interestBiomedicine general; Molecular Medicine; Cell Biology


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2012. I, 299 p. 63 illus., 14 in color. Hardcover7 $189.00ISBN 978-94-007-2818-9

9

P. Salvi, University of Nancy, France

Pulse WavesHemodynamic approach to explain blood pressure values

Recently, several studies have shown the crucial role of viscoelastic properties of the aorta and lar-ge arteries in determining blood pressure values. A good knowledge of cardiovascular pathophysio-logy and vascular hemodynamics is necessary to understand these phenomena. However, available texts on this topic are very complex and difficult for medical practitioners to understand. The aim of this book is to enable the reader to comprehend the relation between cardiovascular pathophysio-logy and vascular hemodynamics and to become familiar with the more recent guidelines. While very complex physical concepts are involved, care has been taken to ensure that the explanations are as straightforward as possible. Complex analyses are presented separately and can be skipped by the reader without impairment of understanding. It is envisaged that the knowledge imparted will prove invaluable in improving the approach to hyperten-sive patients.

Features 7 Straightforward presentation of very complex physical concepts 7 Many figures and user-friendly language, ensuring that the text is readily intelligible 7 Separate presentation of complex analyses in boxes, allowing them to be skipped without impairment of understanding

Contents Introduction.- Mean arterial pressure.- Pulse Pressure.- Central blood pressure.- Appendix.- References.

Fields of interestHuman Physiology; Cardiology


Discount group P

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2012. X, 100 p. 70 illus. Softcover7 approx. $69.95ISBN 978-88-470-2438-0

9



20

F. H. Sarkar, Wayne State University, Detroit, MI, USA (Ed.)

Nutraceuticals and CancerFeatures 7 Neutraceuticals and Cancer Therapy 7 Targe-ted and Adjuvant Therapy 7 Approach reducing systemic toxicity

Contents Preface.-1. Global Overview of the Role of Nutra-ceuticals in Cancer.-2. Cancer Stem Cells: Novel Target Using Dietary Components for Prevention and Treatment.-3. Polyphenols as Receptor Tyro-sine Kinase Inhibitors and Anti-Cancer Agents.-4. Role of Nutraceuticals on Nrf2 and Its Implication in Cancer Prevention.-5. Current Status and Fu-ture Prospects of Nutraceuticals in Prostate Can-cer.-6. Cellular, Molecular and Biological Insight Into Chemopreventive and Therapeutic Potential Of 3, 3’-Diindolylmethane (Dim).-7. Mechanism of Action of the Anti-Cancer Agent, Triptolide.-8. Nutraceuticals in Human Urinary Bladder Cancer Prevention andTreatment.-9. Exploiting resve-ratrol for the treatment of cancer.-10. Role of novel nutraceuticals garcinol, plumbagin and mangiferin in the prevention and therapy of human malig-nancies: mechanisms of anticancer activity.-11. Anthocyanins and Cancer Prevention.-12. Slow but Steady Progress in Cancer Chemoprevention with Phenethyl isothiocyanate: Fulfilled Promises and Translational Challenges.-13. Skin cancer chemoprevention: Current status and future po-tential.-14. Dietary Phytochemicals and Chemo-prevention of Solar Ultraviolet Radiation-Induced Skin Cancer.-15. The Role of Vitamin E Forms in Cancer Prevention and Therapy – Studies in Hu-man Intervention Trials and Animal Models.-16. Augmenting the efficacy of chemo- and radio-the-rapy by nutraceuticals: Evidence from pre-clinical and clinical trials. Index.

Fields of interestBiomedicine general; Cancer Research; Nutrition


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2012. VI, 398 p. 19 illus. in color. Hardcover7 $209.00ISBN 978-94-007-2629-1

9

B. Shapiro, The Pennsylvania State University, University Park, PA, USA; M. Hofreiter, University of York, UK (Eds)

Ancient DNAMethods and Protocols

Contents Setting Up An Ancient DNA Laboratory.-A Phenol-Chloroform Protocol for Extracting DNA from Ancient Samples.-DNA Extraction of Anci-ent Animal Hard Tissue Samples via Adsorption to Silica Particles.- Case Study: Recovery of ancient nuclear DNA from Toe Pads of the Extinct Passen-ger Pigeon.-Extraction of DNA from Paleofeces.-DNA Extraction from Keratin and Chitin.-Case Study: Ancient sloth DNA Recovered from Hairs Preserved in Paleofeces.-Ancient DNA Extraction from Soils and Sediments.-DNA Extraction from Fossil Eggshell.-Ancient DNA Extraction from Plants.-DNA Extraction from Formalin-fixed Material.-Case Study: Ancient DNA recovered from Pleistocene-age Remains of a Florida Armadillo.-Non-destructive DNA Extraction from Museum Specimens.-Case Study: Using a Non-destructive DNA Extraction Method to Generate mtDNA Sequences from Historical Chimpanzee Specimens .-PCR Amplification, Cloning and Sequencing of Ancient DNA.-Quantitative Real-time PCR in aDNA Research.-Multiplex PCR Amplification of Ancient DNA.-Preparation of Next-generation Sequencing Libraries from Da-maged DNA.-Generating Barcoded Libraries for Multiplex High-throughput Sequencing.-Case Stu-dy: Targeted high-throughput Sequencing of Mi-tochondrial Genomes from Extinct Cave Bears via Direct Multiplex PCR Sequencing (DMPS).-Target Enrichment via DNA Hybridization Capture.-Case Study: Enrichment of Ancient Mitochondrial DNA by Hybridization Capture.-Analysis of High-throughput Ancient DNA Sequencing Data. [...]

Fields of interestHuman Genetics


Discount group P

Due February 2012


9

S. D. Skaper, University of Padova, Italy (Ed.)

Neurotrophic FactorsMethods and Protocols

Contents The Neurotrophin Family of Neurotrophic Factors – An Overview.- Neuronal Growth-Promoting and Inhibiting Cues in Neuroprotection and Neu-rodegeneration.- Culture of Rat Cerebellar Granu-le Neurons and Application to Identify Neuropro-tective Agents.- Isolation and Culture of Neural Progenitor Cells from Rat Postnatal Cerebellum.- Culture of Rodent Cortical and Hippocampal Neurons.- Amyloid β-Peptide Neurotoxicity Assay Using Cultured Rat Cortical Neurons.- Culture of Neonatal Rodent Microglia, Astrocytes, and Oligodendrocytes from Cortex and Spinal Cord.- Central Nervous System Neuron-Glia Co-Culture Models.- Culture and Characterization of Rat Mesencephalic Dopaminergic Neurons.- Prepara-tion of Adult Spinal Cord Motor Neuron Cultures Under Serum-Free Conditions.- Rodent Retinal Ganglion Cell Cultures.- Culture of Purified Glial Cell Populations from Optic Nerve.- Isolation and Culture of Rat Cone Photoreceptor Cells.- Rat Retina Pigmented Epithelial Cells.- Mammalian Growth Cone Turning Assays Identify Distinct Cell Signalling Mechanisms that Underlie Axon Growth, Guidance and Regeneration.- Culture of Dissociated Sensory Neurons from Dorsal Root Ganglia of Postnatal and Adult Rats.- Culture and Proliferation of Highly Purified Adult Schwann Cells from Rat, Dog, and Man.- Use of PC12 Cells and Rat Superior Cervical Ganglion Sympathetic Neurons as Models for Neuroprotective Assays Relevant to Parkinson’s Disease.- Compartmen-ted Chambers for Studying Neurotrophic Factor Action.- Preparation and Culture of Adrenal Chromaffin Cells.- Indirect Immunofluorescence Staining of Cultured Neural Cells. [...]

Fields of interestNeurosciences; Neurobiology; Neurochemistry


Discount group P

Due January 2012


9



21

R. Srivastava, S. Shankar, University of Kansas Medical Center, Kansas City, KS, USA (Eds)

Stem Cells and Human DiseasesContents 1. Cancer Stem Cells: Biology, Perspectives and Therapeutic Implications.- 2. The Perspectives of Stem Cell-based Therapy in Neurological Disea-ses.- 3. Stem Cell-based Therapy for Lysosomal Storage Diseases.- 4. Drosophila germline stem cells.- 5. Mesenchymal Stem Cells in Hematopoi-etic Stem Cell Transplantation.- 6. Cancer Stem Cells in Solid Tumors, Markers and Therapy.- 7. Cancer Stem Cells: Paradigm Shifting or Perishing Concept.- 8. Genomics of Prostate Cancer.- 9. Ischemia, reactive radicals, redox signaling and hematopoietic stem cells.- 10. Cancer stem cell models and role in drug discovery.- 11. Origins of Metastasis-Initiating Cells.- 12. The Reduction of Callus Formation during Bone Regeneration by BMP-2 and Human Adipose Derived Stem Cells.- 13. Stem cells and leukemia.- 14. The role of adult bone marrow derived mesenchymal stem cells, growth factors and scaffolds in the repair of cartilage and bone.- 15. Worth the Weight: Adi-pose Stem Cells in Human Disease.- 16. Neural crest and Hirschsprung’s disease.- 17. Common denominators of self-renewal and malignancy IN neural stem cells and GLIOMA.- 18. Stem-like cells from brain tumours or vice versa?.- 19. Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics.- 20. Breast Cancer Stem Cells.- 21. Translin/TRAX deficiency affects mesenchymal differentiation programs and in-duces bone marrow failure.- 22. Cancer therapies and Stem cells.- 23. Cancer Stem Cells and Head and Neck Squamous Cell Carcinomas.- 24. The Biology of Lung Cancer Stem Cells. [...]

Fields of interestBiomedicine general; Literacy; Medicine/Public Health, general


Discount group P

Available

2012. DCCXIII, 13 p. 64 illus., 52 in color. Hardcover7 $279.00ISBN 978-94-007-2800-4

9

H. M. Staines, S. Krishna, University of London, UK (Eds)

Treatment and Prevention of MalariaAntimalarial Drug Chemistry, Action and Use

Features 7 Gives a comprehensive account of the recent advances in anti-malaria drugs 7 Chapters contributed by expert authors 7 Describes new ideas and directions for study

Contents Antimalarial drugs and the control and eliminati-on of malaria.- 4-Aminoquinolines: chloroquine, amodiaquine and next generation analogues.- Cinchona alkaloids: quinine and quinidine.- 8-Aminoquinolines: primaquine and tafenoqui-ne.- Other 4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine, lumefantrine, halofantrine, piperaquine and pyronaridine.- An-tifolates: pyrimethamine, proguanil, sulphadoxine and dapsone.- Naphthoquinones: atovaquone, and other antimalarials targeting mitochondrial func-tions.- Non-antifolate antibiotics: clindamycin, doxycycline, azithromycin and fosmidomycin.- Artemisinins: artemisinin, dihydroartemisinin, artemether, arteether and artesunate.- Second generation peroxides: the OZs and artemiso-ne.- Combination therapy in light of emerging artemisinin resistance.- New medicines to combat malaria: an overview of the global pipeline of therapeutics.- Molecular markers of Plasmodium resistance to antimalarials.- Prevention of mala-ria.- Malaria diagnostics: lighting the path.

Fields of interestPharmacology/Toxicology; Infectious Diseases; Parasitology


Discount group P

Available

2011. XX, 260 p. 57 illus., 15 in color. (Milestones in Drug Therapy) Hardcover7 $189.00ISBN 978-3-0346-0479-6

9

L. W. Tari, Trius Therapeutics, San Diego, CA, USA (Ed.)

Structure-Based Drug DiscoveryThe last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential.

Features 7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents The Utility of Structural Biology in Drug Discove-ry.- Genetic Construct Design and Recombinant Protein Expression for Structural Biology.- Puri-fication of Proteins for Crystallographic Applica-tions.- Protein Crystallization for Structure-Based Drug Design.- X-Ray Sources and High-Throughput Data Collection Methods.- The Use of Molecular Graphics in Structure-Based Drug De-sign.- Crystallographic Fragment Screening.- The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase.- Leve-raging Structural Information for the Discovery of New Drugs: Computational Methods.- Chemical Informatics – Using Molecular Shape Descriptors in Structure-Based Drug Design.- Accounting for Solvent in Structure-Based Drug Design.- Struc-ture-Based Drug Design on Membrane Protein Targets: Human Integral Membrane Protein 5-Lipoxygenase-Activating Protein.- Application of SBDD to the Discovery of New Antibacterial Drugs.- Leveraging SBDD in Protein Therapeutic Development: Antibody Engineering.- A Medi-cinal Chemistry Perspective on Structure-Based Drug Design and Development.

Fields of interestPharmacology/Toxicology; Medicinal Chemistry


Discount group P

Due January 2012

2012. X, 454 p. 129 illus., 17 in color. (Methods in Molecular Biology, Volume 841) Hardcover7 $139.00ISBN 978-1-61779-519-0

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22

A. Thiel, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany (Ed.)

ImmunosenescenceAs individuals age, their ability to respond to and clear pathogens and to control unwanted immune reactions declines, leading to a greater incidence of certain infectious diseases, autoim-munity and general immune dysfunctions. Most remarkably, the efficacy of vaccines is frequently decreased in elderly persons. Therefore, age-as-sociated dysfunctions of the humoral and cellular immune responses have a strong clinical impact. Improving our understanding of the aged immune system is crucial in developing effective preven-tion and treatment programs that will facilitate healthy aging and improve the quality of life of the elderly population.

Features 7 Describes molecular aspects of the aging immune system 7 Discusses new therapeutic approaches 7 Written by internationally reputed scientists

Contents Regulation of Adaptive Immunity in the Elder-ly.- Does Innate Immunity Get Old?.- Thy(-Im)Munosenescence: The Ageing of the Thymus and Its Impact on the Immune System.- Characte-ristics of B Cells and B Cell Responses in Aged Individuals.- Mechanisms of Immune Protection to Pneumococcal Infection in the Young and the Elderly.- CMV Subversion of the Immune System in Later Life.- Aging and Autoimmunity.- Vacci-nation in the Elderly.- Immunosenescence and the 3r’s; Restoration, Replacement and Reprogram-ming.- Novel Strategies of Improved Vaccines for Elderly: The Example of Influenza.

Fields of interestBiomedicine general; Immunology; Molecular Medicine


Discount group P

Available

2012. XX, 225 p. 4 illus., 3 in color. (Birkhäuser Advances in Infectious Diseases) Hardcover7 $189.00ISBN 978-3-0346-0218-1

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H. G. Vogel, J. Maas, Aventis Pharma, Frankfurt, Germany; F. J. Hock, Dieburg, Germany; D. Mayer, Idstein, Germany (Eds)

Drug Discovery and Evaluation: Safety and Pharmacokinetic AssaysFeatures 7 A landmark in the continuously changing world of drugs 7 Essential reading for scientists and managers in the pharmaceutical industry in-volved in drug finding, drug development and de-cision making in the development process 7 Of use for government institutions and committees working on official guidelines for drug evaluation worldwide

Contents From the contents: General Introduction: Safety Pharmacology.- Safety Pharmacokinetics.- Safety Toxicology.

Fields of interestPharmacology/Toxicology


Discount group P

Available

Print

2nd Edition. 2012. 1000 p. (In 2 volumes, not available separately) 7 approx. $679.00ISBN 978-3-642-25239-6

9 eReference

2nd Edition. 2012. 7 approx. $679.00ISBN 978-3-642-25240-2

9 Print + eReference

2nd Edition. 2012. 1000 p. (In 2 volumes, not available separately) 7 approx. $849.00ISBN 978-3-642-25241-9

9
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