hpa axis support booklet -...

Functional & Integrative Medicine Ltd, 77 Austin St, PO Box 19033, Onekawa, Napier 4146 NZPh 0800 439 633 Fax 0800 439 630 [email protected] www.fxmed.co.nz

HPA Axis Support Booklet

Presented by:

Dr Kamal Karl MBBS, FRNZCGP, FACNEM, FNZCAM, FACCS

“HPA Axis Dysfunction in Chronic Disease Management” Webinar

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CONTENTS

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11

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Product

Improve Glycemic Control

Berberine-500

GlucoFunction

Medi Restore

UltraChrome-500

Decrease Inflammatory Signalling

Boswelya Plus

Curcutex

CytoQuel

ProOmega 2000

Increase Circadian Signaling

5HTP-CR

Ayu-Phos

CortisolCalm

L-Tyrosine

Magnesium Glycinate

Sleep & Relax

Balance Neurotransmitters/Neurosteroids

5HTP-CR

Double Strength Zinc Picolinate

L-5MTHF

L-Tyrosine

Magnesium Glycinate

MethylFortify

Page

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Product

Balance Cortisol Feedback Mechanisms

a-Drenal

Ashwagandha

Ayu-Phos

CortisolCalm

L-theanine

Adrenal Support - Protect Zone Reticularis

a-Drenal

Ashwagandha

C-RLA – Liposomal Vitamin C

CytoQuel

Nutrient Support for Adrenal Steroidogenesis

a-Drenal

C-RLA – Liposomal Vitamin C


Magnesium Glycinate

Niacinamide B3

Stress B – complex

Functional Testing

DUTCH Complete

DUTCH Plus

IMPROVE GLYCEMIC CONTROL

1.

Berberine-500 Berberine is an alkaloid present in a number of plants, includingBarberry,Treeturmeric,Oregongrape,Goldensealand Goldthread. Although most well-known for itsantimicrobialactivity(againstbacteria,viruses,protozoans,helminthes, fungi, and Chlamydia), this plant extract alsodemonstratesimportantbenefitsfor:

• Blood-sugarmanagementandinsulinsensitivity.• Cardiovascularsupportandhealthylipidlevels.• Gastrointestinal health – eradication of bacteria

overgrowth(hydrogenicbacteria).• Biofilmdisruptoractivity.• Weight management.• Oncologysupport, immunemodulation,andcognitive

support.

In a three-month clinical study, 116 subjects with type 2 diabetesanddyslipidemiareceivedeither1gberberinedaily or placebo. Statistically significant decreases wereseenintheberberinegroupinfastingandpost-prandialglucose levels,hemoglobinA1c(HbA1c),triglycerides,andtotal- and LDL-cholesterol.

GlucoFunction

A combination of key nutrients, antioxidants and herbalextracts designed to promote healthy glucose uptake and metabolism,microcirculationandpancreaticfunction.

• Chromium,MagnesiumandZinc–keynutrientsinvolvedinglucosetransport,utilizationandgluconeogenesis.

• Gymnema sylvestre – shown to promote healthyglucose uptake into the intestines, supports enzymeactivity for glucose utilization and promotes healthypancreaticbetacellfunction.

• Bitter melon – supports kidney health and bloodglucose metabolism.

• Cinnamon – promotes healthy glucose and lipid metabolismbysupportinghealthyreceptoractivity.

• VitaminCandAlphalipoicacid–antioxidantsupport,redbloodcellandvascularhealth.

• Chromium – shown to bemost effective in reducingdepressive symptoms for those individuals withpronounced carbohydrate craving and over-eatingfeatureswhicharepresentin‘atypicaldepression’.

Suggested Use: 1-2 capsules twice daily.

Clinical Research Paper available from ThorneResearch:A versatile Botanical Compound With Wide Clinical Application available.

Suggested Use: 3 capsules daily, in divideddoses,beforefood.

IMPROVE GLYCEMIC CONTROL

Medi Restore

ResearchNutrition’sMediRestoreisagreattasting,highlyconcentrated nutritional support formula. The formula iscomprisedoflowallergen,synergisticingredientstosupportnumerousbodyprocessesandsystemsincludingdigestion,detoxification, immune function, inflammatory balance,energyproductionandhealthyweightmanagement.

• Providesacompletesourceofprotein,100%certifiedorganic protein –28gramsofproteinperserve.

• Serves as a nutritious meal replacement providing atherapeuticandcomprehensivedoseofBvitaminsandtrace minerals.

• Supports healthy gut membrane integrity.• Providesasourceofprebioticfibreforhealthyintestinal

flora.• Supportshealthydetoxificationandliverfunction.• Contains botanicals Silymarin (Milk Thistle) –

detoxification,antioxidantandliversupport.• Matcha Green Tea powder and Pomegranante husk –

fordigestionandmicrobialbalance.• Ginger –supportsdigestionandbalancedinflammatory

response. • AdditionalaminoacidsGlutamine,GlycineandTaurine

forextrasupport.• Dairy/WheyandSoyfreeandVeganfriendly.

2.

UltraChrome 500

UltraChrome is Thorne Research’s patented chromiumproduct, consisting of chromium arginate and chromium4-oxopyridine, 2,6-dicarboxylate. Compared to otherchromium compounds, including picolinates, thiscombination of chromium chelates appears to have thehighestbioavailability.

• Showntoprovidehightissuelevelsofchromium.• Helpsmaintainhealthybloodsugarlevels.

Each Level Scoop (22.88g) Contains:

Oryza sativa (Rice) seed extract concentrate ........... 10,000 mg equiv. Oryza sativa dry seed ...................... 100,000 mgPisum sativum (Pea) seed extract concentrate ....... 3,320 mg equiv. to Pisum sativum dry seed ............... 28,220 mgL-Glutamine .................................................................... 1,500 mgL-Glycine ......................................................................... 1,500 mgLarix (Larch) Arabinogalactan ........................................ 1,000 mgTaurine .............................................................................. 350 mgAscorbic Acid (Vitamin C) ............................................ 250 mgPalm Tocotrienols Complex (Mixed Vitamin E) .......... 110 mg(from environmentally sustainable source)Choline Dihydrogen Citrate ............................................... 30 mgThiamine Hydrochloride ..................................................... 20 mg equiv. to Thiamine ............................................ 17.8 mgRiboflavin-5-Phosphate Sodium ........................................... 5 mg equiv. to Riboflavin .......................................... 3.93 mgNicotinamide ...................................................................... 50 mgCalcium Pantothenate ....................................................... 55 mg equiv. to Pantothenic Acid ................................. 50 mgPyridoxal-5-Phosphate ........................................................ 15 mg equiv. Pyridoxine ......................................... 10.26 mgCalcium L-5-methyltetrahydrofolate ............................ 220 mcg equiv. Levomefolic acid (L-5MTHF) ................ 200 mcgHydroxocobalamin ......................................................... 200 mcgBiotin ............................................................................... 50 mcgCholecalciferol (Vitamin D3) .......................... (400 IU) 10 mcgMagnesium Citrate ………………………………........…......….. 322 mg equiv. elemental Magnesium …….................……. 50 mg Calcified Lithothamnion Species (Red Algae) .............. 157 mg equiv. to elemental Calcium ................................ 50 mgZinc Citrate Dihydrate ..................................................... 46 mg equiv. elemental Zinc ......................................... 15 mgManganese Glycinate ................................................... 3,700 mcg equiv. elemental Manganese ....................... 1,000 mcgSelenomethionine ............................................................ 130 mcg equiv. elemental Selenium ................................. 50 mcgChromium Nicotinate ……………………………….........…..... 200 mcg equiv. elemental Chromium ……...…................... 25 mcgMolybdenum Trioxide ………………………...........………....… 75 mcg equiv. elemental Molybdenum .......................... 50 mcgPotassium Iodide .............................................................. 65 mcg equiv. elemental Iodine ...................................... 50 mcg Silybum marianum (Milk Thistle) extract (80% Silymarin) ... 150 mg equiv. Silybum marianum dry seed ............... 10,500 mgPunica granatum (Pomegranate Husk) extract ................. 200 mg equiv. Punica granatum dry peel ................... 4,000 mgCamellia sinesis leaf (Matcha Green Tea) powder ............ 250 mg equiv. Caffeine .................................................... 4.5 mgZingiber officinale (Ginger) root powder ........................ 135 mg

Excipients: Medium Chain Triglycerides, Hypromellose, Xanthan Gum, Xylitol, Monk Fruit Extract, Stevia, Natural Vanilla Flavour, Colloidal Anhydrous Silica.

Suggested Use: 1 capsule one to two timesdaily.

Suggested Use:Blend,shake,orbrisklymix1-2scoops with at least 200ml of water/coconutmilk per day.

DECREASE INFLAMMATORY SIGNALING

Boswelya Plus

BoswelyaPlus™containsastandardizedextractofBoswelliaserrata, which supports a healthy inflammatory responseandhealthybloodcirculation. • Zingiber officinale (Ginger), Withania somnifera, and

Curcuma longa have long been used in Ayurveda tohelpprovidesupportforjointandcartilagefunction.

• Curcumin – supports the maintenance of a healthyinflammatoryresponse.

• Glucosamine sulphate and chondroitin – nutritionalsupportforhealthyjoints.

• Bromelain – supportsahealthyinflammatoryresponse.

3.

Curcutex

Curcutex delivers a highly absorbable form of curcumin,using soy-free proprietary Meriva® phytosome complextechnology.

• Curcumin – shown to significantly reduce oxidation,inflammationandpain,offeringthepotentialtosupportabroadrangeofhealthconditions.

• Anti-inflammatory properties – supporting gut, skinand brain.

• Antioxidant properties – supporting vascular andmitochondria.

• May assist muscle recovery, reduce joint pain andstiffness.

Suggested Use: 1 caplet twice to three timesdaily.

Suggested Use: 1-6 capsules daily.

DECREASE INFLAMMATORY SIGNALING

4.

CytoQuel

CytoQuel™ has been developed to promote healthycytokineactivity.Offersyourpatientsaneffectivenewtoolinthequestforhealthyinflammationlevels.

• N-Acetyl-L-Cysteine (NAC) – promotes healthy NF-KBeta,IL-6,IL-8levels.

• BlackTeaExtract –polyphenol EGCGexert their anti-inflammatoryeffectsthroughtheinhibitionoftheNF-Kß signaling pathway, which decreases expression ofseveralinflammatoryproteins.

• CurcuWINTurmericExtract–46%betterabsorbedthanstandard curcumin.

• DeltaGold Tocotrienols – contains pure delta and gamma tocotrienols.

• Resveratrol–naturalTrans-resveratrolinhibitsavarietyofpro-inflammatorycompounds.

ProOmega 2000

Oneofourmostconcentratedformulas,highlevelsofEPAand DHA for those needing intensive support. Researchshows that EPA promotes cardiovascular health, jointmobility, proper immune function, and gastrointestinalhealth. EPA has also been shown to support a healthy mood.

• Deliciousnaturallemonflavour.• HighlyconcentratedEPAandDHAformula.• Promotescardiovascularhealth.• Promotesbrain,eye,andneurologicalhealth.• Supportsgastrointestinalhealth.• Helpsoptimizeimmunefunction.• Triglyceride form for better absorption of essential

omega-3s.• Contains Essential Fatty Acids (EFA) to help with

inflammatorysignaling.

Suggested Use:1capsuledailywithamealforthefirstweek,and3capsulesdailywithamealin week two and beyond.

Suggested Use: 2 capsules once to twice daily withfood.

INCREASE CIRCADIAN SIGNALING

5-HTP CR 100mg

5-hydroxytryptophan (5-HTP) is a precursor to serotonin.Supplementingwith5-HTPbypassesthesomewhatlimitedconversion of tryptophan to 5-HTP. Oral 5-HTP is well-absorbedintheintestinewithouttheneedforatransporter;otheraminoacidsdonotcompetewithitforabsorption.

• Supportshealthybiosynthesisofserotonin.• Supportshealthymoodandpositiveoutlook.• Promotesanormalappetiteandarestfulsleeppattern.• 5-HTP CR – controlled released tablet designed to

naturallyincreasethebody’slevelofserotoninquicklyandsteadilyovera12-hourperiod.

5.

Ayu-Phos

AyuPhos™ is soy-free and is naturally derived fromsunflowers. Phosphatidylserine is a natural phospholipidessentialforpropercellfunctionandsignalingandisfoundinparticularlyhighlevelsinthebrain.

• An important cell membrane phospholipid.• Promotescognitivefunction,ahealthystressresponse

and sleep. • Supportsmentalacuity,memoryandhealth.• Promotesemotionalwell-being.• Helpsmodulatecortisollevelsduringstress.• Improvescelltocellcommunicationinthebrain.• Improves cell metabloism (glucose utilisation) and

enhancedneurotransmitterformation.• Enhancesrecoveryfromstrenuousexercise.• Boundtoioniccalciumandmagnesiumwhichimprove

theabsorptionandutilizationofphosphatidylserineinthe body.

Suggested Use: 1 capsule once to twice daily.

Suggested Use: 1-3 tablets daily, individualdoses,beforemeals.

Magnesium Glycinate

Magnesiumactivatestheenzymesnecessaryforanumberof physiological functions, including neuromuscularcontractions, cardiac function, and the regulation of theacid-alkaline balance in the body.

• Magnesiumisanutritionalcofactorforserotonin.• ThisvitalmineralalsohelpsutilizeB-complexvitamins,

vitaminC,andvitaminE.• Magnesium also plays important roles in muscle

function,moodandcalming,andcranialvesselcomfort.• Magnesium helps activate neurotransmitters that are

responsibleforcalmingthebodyandthemind.• May help prepare your body andmind for sleep, by

calmingthenervoussystem.• Italsoregulatesthehormonemelatonin,whichguides

sleep-wake cycles in your body.

INCREASE CIRCADIAN SIGNALING

Sleep & Relax

Sleep&Relaxformula–ablendoforganicherbstraditionallyrecognized to support tranquil sleep, promotes a healthysleep cycle by calming tension and helping the mind unwind.

• Valerian–helpsimprovequalityofsleep,andreducesthetimeittakestofallasleep.Valeriandoesnotcausesomnolenceinthemorningoraffectdreamrecall.

• Passionflower – a knownnervine relaxant. Passiflorahasbeendemonstratedtocauseallostericmodulationof GABA-A receptor complex via interaction at thebenzodiazepinesite.

• Lemonbalm,Californiapoppy,LavenderandMarjoram–aproprietaryblendofcalming,restorativeherbs.

• Botanicalsofferawell-tolerated,lowtoxicityoptionforimprovingsleepquality.

• Aidsrelaxationandcalmsnervousagitation.• Promotesrelaxingandrestorativesleep.

6.

Suggested Use: 1–4capsulesdaily, individeddoses,withmeals.

Suggested Use: 2-3 capsules one to two hours beforebed.

L-Tyrosine

L-tyrosine is an amino acid precursor for synthesis of theneurotransmitters norepinephrine and dopamine. Thisimproved rate of neurotransmitter synthesis, stimulatesthecentralnervoussystem.L-tyrosineappearstofunctionasanadaptogenbyrelievingphysical symptomsofstress,suchasmoodswings.ChronicallystressedindividualsmaynotefficientlyconvertphenylalaninetoL-tyrosine,makingsupplementationwithL-tyrosinedesirable.

• Essential for neurotransmitter and thyroid hormonesynthesis. Supports the thyroid gland.

• Stimulatesgrowthhormoneandisinvolvedinadrenalandpituitaryfunction.

• A powerful antioxidant, scavenging and neutralizingfreeradicalsandinhibitingfatoxidation.

• Promotes a positive mental state and healthy stressmanagement.

Suggested Use: 1capsulethreetimesdaily.

25mg

7.

BALANCE NEUROTRANSMITTERS/NEUROSTEROIDS


Zinc is essential for growth, immune system function,testosteronemetabolism,asacofactorfortheantioxidantenzymesuperoxidedismutase,andformanyotherfunctionsinthebody.Zincisinvolvedinthefunctioningofover200enzymes and plays a key role in genetic expression, celldivision, and growth. Zinc deficiency has been associatedwith adverse impacts on a number of structures andfunctionsofthebody.

• Zinc deficiency is common in those who suffer fromPyrolledisorder(Pyroluria)duetoHPLbindingtozinc,renderingitunavailablefornormalfunctions.

• Essentialforgrowthandimmunefunction.• Promotesreproductivehealth.• Picolinicacidfacilitatestheabsorptionofminerals,Zinc

Picolinate is absorbed to a higher degree than other zincsupplements.

5-HTP CR 100mg

5-hydroxytryptophan (5-HTP) is a precursor to serotonin.Supplementingwith5-HTPbypassesthesomewhatlimitedconversion of tryptophan to 5-HTP. Oral 5-HTP is well-absorbedintheintestinewithouttheneedforatransporter;otheraminoacidsdonotcompetewithitforabsorption.

• Supportshealthybiosynthesisofserotonin.• Supportshealthymoodandpositiveoutlook.• Promotesanormalappetiteandarestfulsleeppattern.• 5-HTP CR – controlled released tablet designed to

naturallyincreasethebody’slevelofserotoninquicklyandsteadilyovera12-hourperiod.

Suggested Use: 1 capsule once daily.

Suggested Use: 1-3 tablets daily, individualdoses,beforemeals.

L-5MTHF

Research Nutrition’s L-5MTHF is a pure and highlybioavailable form of folate. Directly facilitating methylgroupdonation in thebody, L-5MTHF supportsnumerousmetabolic processes for optimum healing, development,detoxification,mentalhealthandwellbeing.

• Providesamethylatedandmetabolicallyactiveformoffolate.

• Bypasses the biochemical steps normally required by otherfolates.Demonstratesgreatermetabolicactivitythan folic acid as a source of folate, with reducedpotentialforsideeffects.

• Contributestothenormalgrowthofthefoetusduringpregnancy.

• May support normal stress and cognitive functionthroughhealthyneurotransmitterproduction.

• Supportshealthyredbloodcellformation.• Plays an important role in supporting healthy

methylation.• Supports healthy homocysteine levels, cardiovascular

andvascularendothelialfunction.

Suggested Use: 1 capsule daily.

BALANCE NEUROTRANSMITTERS/NEUROSTEROIDS

8.

Methyl Fortify

Invaluablefordeliveringhighlyfocusedclinicalmethylationsupport,andtheoptimisationofcardiovascular,neurologicalanddetoxificationfunction.

• ProvidestheexternallymethylatedformsoffolateandvitaminB12.

• Activated forms of vitamin B2 and B6 provide crucialco-factorsupportforthepropermetabolismoffolate,B12andmethylation.

• ProvidesatherapeuticdoseofcholineforsupportofthealternateBHMThomocysteinemethylationpathway.

• May help to support the maintenance of healthyhomocysteinelevelsviaremethylationofhomocysteineback to methionine.

Magnesium Glycinate

Highly bioavailable magnesium chelate for sensitiveindividuals. Magnesium activates the enzymes necessaryfor a number of physiological functions, includingneuromuscular contractions, cardiac function, and theregulationoftheacid-alkalinebalanceinthebody.

• Magnesiumisanutritionalcofactorforneurotransmitterserotonins. Helps activate neurotransmitters that areresponsibleforcalmingthebodyandthemind.

• The body uses Magnesium for of 300 enzymaticreactions.

• ThisvitalmineralalsohelpsutilizeB-complexvitamins,vitaminC,andvitaminE.

• Magnesium also plays important roles in muscle function,moodandcalming,andcranialvesselcomfort.


Suggested Use: 1 capsule daily.

Suggested Use: 1capsulethreetimesdaily.

L-Tyrosine

L-tyrosine is an amino acid precursor for synthesis of theneurotransmitters norepinephrine and dopamine. Thisimproved rate of neurotransmitter synthesis, stimulatesthecentralnervoussystem.L-tyrosineappearstofunctionasanadaptogenbyrelievingphysical symptomsofstress,suchasmoodswings.ChronicallystressedindividualsmaynotefficientlyconvertphenylalaninetoL-tyrosine,makingsupplementationwithL-tyrosinedesirable.

• Essential for neurotransmitter and thyroid hormonesynthesis. Supports the thyroid gland.

• Stimulatesgrowthhormoneandisinvolvedinadrenalandpituitaryfunction.

• A powerful antioxidant, scavenging and neutralizingfreeradicalsandinhibitingfatoxidation.

• Promotes a positive mental state and healthy stressmanagement.

BALANCE CORTISOL FEEDBACK MECHANISMS

9.

Ashwagandha

Ashwagandha, also known as Indian ginseng, and a dailyrasayana is one of the most highly regarded and widelyusedAyurvedicherbs. It acts as an adaptogen to supporttheimmunesystem,nourishingandstrengtheningtheinnerreserveofthehumanbody.

Suggested Use: 1capsuletwicetothreetimesdaily.

Suggested Use: 1 capsule once to twice daily.

• The key constituents of Ashwagandha, withanoloids,plan an important role in its ability to promote physical andmentalhealth,i.e.occasionalstress,cognitiveandbrain function, immune system support and healthymetabolism.

• The withanolides serve as important hormoneprecursors that convert into human physiologichormones as needed by the body that act as a natural anti-inflammatory.

• Helpsrestorevitalitytothosesufferingfromoverworkornervousexhaustion,oracute/chronicstress.

• Promotes physical and mental health. • Anti-stressandsupportivetotheadrenalglands.• Supportstheactivityoflymphocytesandmacrophages

andmaypromotethyroidfunctionhealth.

Ayu-Phos

AyuPhos™ is soy-free and is naturally derived fromsunflowers. Phosphatidylserine is a natural phospholipidessentialforpropercellfunctionandsignalingandisfoundinparticularlyhighlevelsinthebrain.

• An important cell membrane phospholipid.• Promotescognitivefunction,ahealthystressresponse

and sleep. • Supportsmentalacuity,memoryandhealth.• Promotesemotionalwell-being.• Helpsmodulatecortisollevelsduringstress.• Improvescelltocellcommunicationinthebrain.• Improves cell metabloism (glucose utilisation) and

enhancedneurotransmitterformation.• It is also helpful during recovery from strenuous

exercise. • This flower-powered brain food is bound to ionic

calciumandmagnesiumwhichimprovetheabsorptionandutilizationofphosphatidylserineinthebody.

10.

BALANCE CORTISOL FEEDBACK MECHANISMS

Cortisol Calm

Cortisol Calm is a blend of herbal extracts and vitamin Ddesignedtomaintainhealthycortisollevelsandtosupportrelaxation,restfulsleepandpositivemoodduringtimesofstress.

• In a recent study, Sensoril® Ashwagandha extractpromoted relaxation and maintained healthycortisol and C-reactive protein levels. Subjects in thisrandomized, double blind, placebo-controlled studyreportedsupportforhealthysleep,positivemoodandcognitivefunction.Theeffectsweremostpronouncedforsubjectstaking500mgperdaycomparedtolesserdoses.

• Rhodiola and Magnolia – supports healthy adrenal cortisolactivityandofferssupportforstress,moodandemotionalwell-being.

• L-Theanine – supports normal brain alpha-waveactivity,helpingcalmthesympatheticnervoussystemforarelaxingeffect.

• Vitamin D – recent research suggests that maintaining healthy vitamin D levels supports normal cortisolproductionwithinabdominaladipocytes.

L-Theanine

L-Theanine is a naturally occurring, amino acid found ingreen tea leaves. L-Theanine has shown to reduce stressby promoting relaxation without drowsiness, easingnervousness due to overwork and fatigue, and reducingnervousirritability.

• Supportsnervoussystemhealthandfunction.• May reduce systolic and diastolic blood pressure.• Supportsantioxidantanddetoxificationmechanisms.• Increases levels of dopamine and improves mental

awareness.• IncreasesGABAandreducesrestlessness,insomniaand

otherdisruptedconditions.• L-Theanine – supports normal brain alpha-wave

activity,helpingcalmthesympatheticnervoussystemforarelaxingeffect.

• L-theanine also appears to support neurological health by exerting a positive and significant impactonneurotrophicfactorsinthebrainandassistingcell-signalingactivity.

• Research suggests that L-theaninepositively supportsoverall nervous system health and activity due to itspositive effects on serotonin, dopamine, and GABAlevels, as well as its modulation of excitatory andinhibitory neurotransmission.

Suggested Use: 1 capsule in the morning and eveningwithmeals.

Suggested Use: 1-2 capsules twice daily.

ADRENAL SUPPORT - PROTECT ZONE RETICULARIS

11.

a-Drenal

Provides comprehensive support from stress inducedsymptoms, supportsadrenal functionandpromotescalm,balanced physical and mental energy.

• Comprehensive formulation of organic adrenal tissueand adaptogenic herbs.

• Helps maintain and normalize healthy cortisol andbloodsugarlevels.

• Supportshealthyadrenalfunction.• The adrenal cortex is responsible for synthesis of

corticosteroids therefore adrenal extracts play a rolein supporting normal adrenal function and healthycortisollevels.Thishelpsmaintainnormalimmuneandstressresponsesandmanyothervitalprocessesinthebody.

• Beta-Sitosterol – a plant sterol, known to aid theimmune system by maintaining a healthy balance between Th-1 and Th-2 white blood cells. It also helps tomodulatethestressresponsebysupportingnormalcortisolandDHEAlevels.

Suggested Use: 2 capsules twice daily.

CytoQuel

CytoQuel™ has been developed to promote healthycytokineactivity.Offersyourpatientsaneffectivenewtoolinthequestforhealthyinflammationlevels.

• N-Acetyl-L-Cysteine (NAC) – promotes healthy NF-KBeta,IL-6,IL-8levels.

• BlackTeaExtract –polyphenol EGCGexert their anti-inflammatoryeffectsthroughtheinhibitionoftheNF-Kß signaling pathway, which decreases expression ofseveralinflammatoryproteins.

• CurcuWINTurmericExtract–46%betterabsorbedthanstandard curcumin.

• DeltaGold Tocotrienols – contains pure delta and gamma tocotrienols.

• Resveratrol–naturalTrans-resveratrolinhibitsavarietyofpro-inflammatorycompounds.

Suggested Use: 1 capsule daily with a meal for thefirstweek,and3capsulesdailywithameal in week two and beyond. They may be taken at the same meal or spread amongst your meals.ForbestresultstakeawayfromVitaminE(tocopherol).

C-RLA

C-RLA™ offers a safe, efficacious delivery system of highdoseVitaminCandR-LipoicAcidinoneformulation.

• Eachservingcontains1500mgofVitaminCand70mgof R-Lipoic Acid in a natural (GMO-free) liposomalpreparation.

• Lipoic acid helps protect against oxidative stressgeneratedbyhighglucoselevels.

• The pure R-Lipoic Acid in C-RLA™ supports a healthy inflammatory response and is a potent free-radicalscavenger. Suggested Use:10ml (twoteaspoons)onceor

twiceperday,awayfromfood.

12.

NUTRIENT SUPPORT FOR ADRENAL STEROIDOGENESIS

Suggested Use: 2 capsules twice daily.

a-Drenal

Provides comprehensive support from stress inducedsymptoms, supportsadrenal functionandpromotescalm,balanced physical and mental energy.

• Comprehensive formulation of organic adrenal tissueand adaptogenic herbs.

• Helps maintain and normalize healthy cortisol andbloodsugarlevels.

• Supportshealthyadrenalfunction.• The adrenal cortex is responsible for synthesis of

corticosteroids therefore adrenal extracts play a rolein supporting normal adrenal function and healthycortisollevels.Thishelpsmaintainnormalimmuneandstressresponsesandmanyothervitalprocessesinthebody.

• Beta-Sitosterol – a plant sterol, known to aid theimmune system by maintaining a healthy balance between Th-1 and Th-2 white blood cells. It also helps tomodulatethestressresponsebysupportingnormalcortisolandDHEAlevels.

Stress B-complex

A vitamin B-complex with extra B5 for adrenal supportandstressmanagement.StressB-ComplexcontainsactiveB-vitamin forms for enhanced absorption. Healthy HPAaxis play an important role inmanaging stress effectively.Pantothenic acid (vitamin B5) is part of the B-vitamincomplex and is essential for healthy adrenal and immunefunction. In particular, pantothenic acid serves as thestartingmaterialforthesynthesisofcoenzymeA,whichisimportant formetabolismof fatsandsynthesisofadrenalhormones.Pantothenicacidplaysakeyroleintheformationof acetylcholine, which is needed in the transmission ofnerveimpulses.

• Stress B-Complex consists of a group of eight water-soluble compounds.

• Although each B vitamin is chemically distinct, theyregularly work together in various biochemicalfunctions throughout the body – including cellularenergy production, healthy red-blood-cell formation,andhealthyneurologicalfunction.

• Most B vitamins, with the exception of vitamin B12,are not stored in the body; consequently, theymustbe acquired daily from the diet in order tomaintainoptimalhealth.

Suggested Use: 1 capsule one to three timesdaily.

13.


C-RLA

C-RLA™ offers a safe, efficacious delivery system of highdoseVitaminCandR-LipoicAcidinoneformulation.

• Eachservingcontains1500mgofVitaminCand70mgof R-Lipoic Acid in a natural (GMO-free) liposomalpreparation.

• Lipoic acid helps protect against oxidative stressgeneratedbyhighglucoselevels.

• The pure R-Lipoic Acid in C-RLA™ supports a healthy inflammatory response and is a potent free-radicalscavenger.

25mg

Suggested Use:10ml (twoteaspoons)onceortwiceperday,awayfromfood.


Zinc is essential for growth, immune system function,testosteronemetabolism,asacofactorfortheantioxidantenzymesuperoxidedismutase,andformanyotherfunctionsinthebody.Zincisinvolvedinthefunctioningofover200enzymes and plays a key role in genetic expression, celldivision, and growth. Zinc deficiency has been associatedwith adverse impacts on a number of structures andfunctionsofthebody.

• Zinc deficiency is common in those who suffer fromPyrolle disorder (Pyroluria) due to HPL binding tozinc, rendering it unavailable for normal functions.Supplementing with Zinc Picolinate may reducePyrolle levelsandseverityof thesignsandsymptomsexperienced.

• Essentialforgrowthandimmunefunction.• Promotesreproductivehealth.• Picolinicacidfacilitatestheabsorptionofminerals,Zinc

Picolinate is absorbed to a higher degree than is other zincsupplements.

• Contains25mgofzincpercapsule.

Suggested Use: 1 capsule once daily.

14.


Niacinamide B3

Research Nutrition’s Niacinamide B3 is a pure andhypoallergenicsourceofnon-flushingvitaminB3.Supportingcellular mitochondrial energy production and anti-aging,detoxification,skinprotection,andcalmingofneurologicalover-excitation(includingfromover-methylation).

• Nicotinamide improves choline retention and mayassist intheconsumptionofexcesscirculatingmethylgroups.

• Thisoptimisationofnicotinamideand choline/methylgroup availability is important for brain function andthepreventionofdegenerativeneurologicalconditions.

• EssentialtotheformationofNADandNADP,involvedinover400enzymereactionsinthebody.

• Assists the metabolism of carbohydrates, fats, andproteins.

• Mayhelpcalmthenervoussystem.• May assist in the detoxification of alcohol and the

recyclingofglutathione.• Enhancesmitochondrialquality,functionandlifespan.

Magnesium Glycinate

Highly bioavailable magnesium chelate for sensitiveindividuals. Magnesium activates the enzymes necessaryfor a number of physiological functions, includingneuromuscular contractions, cardiac function, and theregulationoftheacid-alkalinebalanceinthebody.

• Magnesiumisanutritionalcofactorforneurotransmitterserotonins.

• The body uses Magnesium for of 300 enzymaticreactions.

• ThisvitalmineralalsohelpsutilizeB-complexvitamins,vitaminC,andvitaminE.

• Magnesium also plays important roles in muscle function,moodandcalming,andcranialvesselcomfort.

• Nutrient Utilization; Bone Health and CardiovascularSupport.

• Supports metabolism of carbohydrates, amino acidsandfats;alsoforenergyproduction,andtheutilizationofcalcium,phosphorus,sodium,andpotassium.

• Supports sleep.


Suggested Use: 1-4 capsules daily.

FUNCTIONAL TESTING

DUTCH Complete

Thisadvancedhormonetestingwasdevelopedtosurpassindustrystandardsforavailabletestingoptions.DUTCHtestingoffersthemostextensiveprofileofsexandadrenalsteroidhormones,alongwiththeirall-importantmetabolites.Thedaily(diurnal)patternoffreecortisol,alongwithmelatoninisincluded.Thisuniquecombinationofclinicalinformationisnotavailablebyanyothertestingmethod.

Thisadvancedhormonetestingwasdevelopedtosurpassindustrystandardsforavailabletestingoptions.DUTCHtestingoffersthemostextensiveprofileofsexandadrenalsteroidhormones,alongwiththeirall-important metabolites.

EFFECTIVE HRT MONITORING

DUTCHtestingwasspecificallymadetobeoptimallyeffectiveformostformsofhormonereplacementtherapy.Uniquemethodsareusedforimprovedmonitoringoforalprogesteroneandvaginalhormones.

THE EASIEST COLLECTION

Patientscollectjustfourorfivedriedurinesamplesovera24-hourperiod.Driedspecimensamplesareconvenienttocollect,easytoshipandstableforseveralweeks.

CLINICAL VALIDATIONAllPrecisionAnalyticaltestingmethodsgothrougharigorousandongoingvalidationprocesstoverifyaccuracy,precision,recovery,linearity,etc.inthepursuitofthe most accurate and precise techniques availableforhormonetesting.

15.

The DUTCH Plus™ Report includes:

DUTCH Complete (MetabolitesofEstrogens,Androgens,Progesterone,Cortisol,Melatoninand8-OHdG).PLUSCortisol Awakening Response (CAR)-showsincrementalcortisollevelsuponwaking,whichprovidesvaluableinformationonHPAAxisfunction.

What is the Cortisol Awakening Response and how do we test for it?• Uponwaking,cortisollevelsnaturallybegintoriseby50%.30minutesafterwaking,cortisollevelswillstillshowthis

sharpincrease.By60minutesafterwaking,cortisollevelshavepeakedandbegintodecline.• Measuringthisriseandfallofcortisollevelsatwakingcanbeusedasa“ministresstest”.• ResearchshowsthatthesizeofthisincreasecorrelateswithHPAAxisfunction,evenifthesamplemeasurementsare

all within range. • TheassessmentofthisendocrineresponseisabletouncoversubtlechangesinHPAAxisactivity,whichisassociated

withvarioushealthconditionsandriskfactors.• Aquicksaturationofsalivaswabsuponwaking,andat30and60minutesafterwaking,providewhatisrequiredto

assessapatient’sCortisolAwakeningResponse.

A low Cortisol Awakening Response • ThiscanbearesultofanunderactiveHPAAxis,excessivepsychologicalburnout,seasonalaffectivedisorder(SAD),

sleepapneaorpoorsleepingeneral,PTSD,chronicfatigueand/orchronicpain.• AdecreasedCARhasalsobeenassociatedwithsystemichypertension,functionalGIdiseases,postpartum

depression,andautoimmunediseases.

An elevated Cortisol Awakening Response• Thiscanbearesultofanover-reactiveHPAAxis,ongoingjobrelatedstress(anticipatorystressfortheday),glycemic

dysregulation,pain(i.e.wakingwithpainfuljointsormigraine),andgeneraldepression(notSAD).• Arecentstudyshowedthatneitherthewakingnorpost-wakingcortisolresultscorrelatedtoMajorDepressive

Disorder,buttheCARcalculation(thechangebetweenthefirsttwosamples)did.• Thismeasurementoftheresponsetowakinghasindependentclinicalvalueshowingdysfunctionthatmaybehidden

bycurrenttestingoptions.

What’s Included in the DUTCH Plus™? • TheDUTCHPlus™usesfourdriedurinesamplesandfivesalivasamples.• Thesesamplesarecollectedoverthecourseofoneday,fromwakingtobedtime.

FUNCTIONAL TESTING

16.

Functional & Integrative Medicine Ltd, 77 Austin St, PO Box 19033, Onekawa, Napier 4146, NZPh 0800 439 633 Fax 0800 439 630 [email protected] www.fxmed.co.nz

PleasecallourTechnicalSupportTeamon0800439633ifyouhavefurtherquestionsoremail [email protected]

Australian customerspleasecontactoursistercompanyResearchNutritionforfurtherinformationontestingor

ResearchNutritionproductsmentionedinthisbooklet.Phone:1800110158orEmail:[email protected]

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