hp labs escondido, ca methanol and ethanol analysis/ j. picker the ultimate gourmet martini
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HP Labs Escondido, CA
Methanol and Ethanol Analysis/
J. Picker
The Ultimate Gourmet Martini
HP Labs Escondido, CA
Objective Analyze methanol and ethanol
at 100-1000 ug/L or lower Use standard or modified EPA
Methods Provide adequate Turnaround
and pricing to meet client needs
Make a profit
HP Labs Escondido, CA
Warning Methanol is “wood alcohol”
minimum lethal dose 1g/kg but toxic effects as low as 10g.
toxicity is due to metabolic production of formic acid
Ethanol is less toxic
HP Labs Escondido, CA
Problems Very Poor purging efficiency (i.e.,
NO 5030/5035) Allowed Prep. Techniques
5031 Azeotropic distillation 5032 Vacuum distillation 5021 Equilibrium Headspace =nd 5041 VOST train = nd Direct Inject
HP Labs Escondido, CA
Problems II Low sensitivity on FID and
MS Interferences by HCs and
other compounds on FID
HP Labs Escondido, CA
HP Labs’ Solution Direct Aqueous injection/EPA
Method 8260B GC Column and conditions to
separate MeOH, EtOH from water Stable Labeled isotope internal
standards (CD3OH,CD3CH2OH) Modified with Selected Ion
Monitoring Mass Spectrometry (SIM)
HP Labs Escondido, CA
HP Labs Escondido, CA
HP Labs Escondido, CA
HP Labs Escondido, CA
HP Labs Escondido, CA
Sample Preparation: water Sample Size 1 mL Add Labeled IS Solution Inject
HP Labs Escondido, CA
Sample Preparation: Soil Ultrasonic extraction (EPA 3550)
10 g/10 mL Remove 1mL Add IS Inject
HP Labs Escondido, CA
Detection Limits Water and Soil
MDLs < 100 ug/L (ug/kg) EQLs 250 ug/L (ug/kg)
HP Labs Escondido, CA
What This Means
Methanol and Ethanol on site or off site
Rapid turnaround All levels of QC Price as low as fixed base