hospital infections infectious diseases department yeditepe university hospital meral sÖnmezoĞlu,...
TRANSCRIPT
HOSPITAL INFECTIONS
Infectious Diseases DepartmentYeditepe University Hospital
Meral SÖNMEZOĞLU, MD, Assoc Prof
• 1. Know the general terminology and definitions
• 2. Know epidemiology
• 3. Understand the importance of the hospital infections
• Explain the prevention
Learning objects
DEFINITION
• The term nosocomial infection or health-care associated infection is applied to “any clinical infection that was neither present nor was in its incubation period at the time of admission to the acute care setting”.
• Nosocomial infections may also make their appearance after discharge from the hospital, if the patient was in the incubation period at the time of discharge
Most Common Types of Nosocomial Infections
• Most Common Types of Nosocomial Infections:
1. Urinary tract infections.
2. Surgical wound infections.
3. Lower respiratory Tract infections (primarily
pneumonia).
4. Bloodstream infections (septicaemia)
Nabeel Al-Mawajdeh RN.MCS
Burden of Healthcare-Associated Infections in the United States, 2002
• 1.7 million infections in hospitals– Most (1.3 million) were outside of ICUs– 9.3 infections per 1,000 patient-days– 4.5 per 100 admissions
• 99,000 deaths associated with infections– 36,000 – pneumonia– 31,000 – bloodstream infections
Klevens, Edwards, Richards, et al. Pub Health Rep 2007;122:160-6
Calculation of estimates of healthcare-associated infections in U.S. hospitals among adults and children outside of
intensive care units, 2002
HRN = high risk newbornsWBN -= well-baby nurseriesICU = intensive care unitSSI = surgical site infectionsBSI – bloodstream infectionsUTI = urinary infectionsPNEU = pneumonia
SSI20%
BSI11%
UTI36%
PNEU11%
Other22%
133,368
424,060
263,810
129,519
274,098
-967
-21
-28,725
244,385
TOTAL
HRN
WBN
Non-newborn ICU
= SSI
Klevens, Edwards, Richards, et al. Pub Health Rep 2007;122:160-6
Estimated number of HAIs by site of infection
Major site of Infection Estimated Number of Infections Range of $ estimates based on 2007 CPI for Inpatient hospital services
Healthcare-Associated Infection (all HAI)
1,737,125 $20,549 - $25,903
Surgical Site Infection (SSI) 290,485 $11,087 - $29,443 Central Line Associated Bloodstream Infections (CLABSI)*
92,011 $ 6,461 - $25,849
Ventilator-associated Pneumonia (VAP)**
52,543 $14,806 - $27,520
Catheter associated Urinary tract Infection (CAUTI)***
449,334 $ 749 - $ 832
Clostridium difficile-associated disease (CDI)17
178,000 $ 5,682 - $ 8,090
Attributable Costs of Nosocomial Infections
Cost per Infection
Wound infections $3,000 - $27,000
Sternal wound infection $20,000 - $80,000
Catheter-associated BSI
$5,000 - $34,000
Pneumonia $10,000 - $29,000
Urinary tract infection $700
Nettleman M. In: Wenzel RP, ed. Prevention and Control of Nosocomial Infections, 4th ed. 2003:36.
SOURCES• Infectious agents from endogenous or exogenous
sources.
• Endogenous sources are body sites, such as the skin, nose, mouth, gastrointestinal (GI) tract, or vagina that are normally inhabited by microorganisms.
• Exogenous sources are those external to the patient, such as patient care personnel, visitors, patient care equipment, medical devices, or the health care environment
Modes of Transmission of Infections
1. Contact:
- Direct e.g., hands of hospital personnel.
- Indirect e.g., using contaminated objects.
2. Contaminated vehicles used in common for patients e.g., instruments, contaminated food, water, solutions, drugs or blood products.
3. Airborne e.g., aerosol, droplets or dust.
Nabeel Al-Mawajdeh RN.MCS
Modes of Transmission of Infections (Cont’d)
4. Vector borne: e.g., mosquitoes.
5. Blood borne: inoculation injury or sexual transmission e.g., HBV, HIV.
Nabeel Al-Mawajdeh RN.MCS
Patients Most Likely to Develop Nosocomial Infections
1. Elderly patients.
2. Women in labor and delivery.
3. Premature infants and newborns.
4. Surgical and burn patients.
5. Diabetic and cancer patients.
6. Patients receiving treatment with steroids, anticancer drugs, antilymphocyte serum, and radiation.
Nabeel Al-Mawajdeh RN.MCS
Patients Most Likely to Develop Nosocomial Infections (Cont’d)
7. Immunosupressed patients (I. e., patients whose immune systems are not functioning properly)
8. Patients who are paralyzed or are undergoing renal dialysis or catheterization; quite often, these patient’s normal defence mechanisms are not functioning properly)
Nabeel Al-Mawajdeh RN.MCS
Major Factors Contributing to Nosocomial Infections
1. An ever- increasing number of drug-resistant pathogens.
2. Lack of awareness of routine infection control measures.
3. Neglect of aseptic techniques and safety precautions.
4. Lengthy complicated surgeries.
5. Overcrowding of hospitals.
Nabeel Al-Mawajdeh RN.MCS
Major Factors Contributing to Nosocomial Infections (Cont’d)
6. Shortage of hospital staff.
7. An increased number of Immunosupressed patients.
8. The overuse and improper use of indwelling medical devices.
Nabeel Al-Mawajdeh RN.MCS
Outline• Nosocomial Infections are a significant cause
of morbidity and mortality• There has been increased public interest in
nosocomial infections• Shifting paradigm
– Many infections are preventable
Shifting Vantage Points on Nosocomial Infections
Gerberding JL. Ann Intern Med 2002;137:665-670.
Many infections are inevitable, although
some can be prevented
Each infection is potentially
preventable unless proven otherwise
Epidemiology• 5-10% of patients admitted to acute care hospitals
acquire infections– 2 million patients/year– ¼ of nosocomial infections occur in ICUs– 90,000 deaths/year– Attributable annual cost: $4.5 – $5.7 billion
• Cost is largely borne by the healthcare facility not 3rd party payors
Weinstein RA. Emerg Infect Dis 1998;4:416-420.Jarvis WR. Emerg Infect Dis 2001;7:170-173.
Nosocomial Infections
• 70% are due to antibiotic-resistant organisms
• Invasive devices are more important than underlying diseases in determining susceptibility to nosocomial infection
Burke JP. New Engl J Med 2003;348:651-656.Safdar N et al. Current Infect Dis Reports 2001;3:487-495.
Major Sites of Nosocomial Infections
• Urinary tract infection
• Bloodstream infection
• Pneumonia (ventilator-associated)
• Surgical site infection
IMPORTANT SOURCES
(a) Contaminated air, water, food and medicaments
(b) Used equipments and instruments
(c) Soiled linen
(d) Hospital waste (Bio medical waste)
Surgical Site Infections
SSI level classification Incisional SSI - Superficial incisional = skin and
subcutaneous tissue - Deep incisional = involving deeper soft tissue Organ/Space SSI - Involve any part of the anatomy (organs
and spaces), other than the incision, opened or manipulated during operations
Definition of Surgical Site Infections
Superficial Incisional SSI
Infection occurs within 30 days after the operation and involves only skin or subcutaneous tissue of the incision
Mangram AJ et al. Infect Control Hosp Epidemiol. 1999;20:250-278.
Subcutaneous tissue
SkinSuperficial incisional SSI
Deep Incisional SSI
Infection occurs within 30 days after the operation if no implant is left in place or within 1 year if implant is in place and the infection appears to be related to the operation and the infection involves the deep soft tissue (e.g., fascia and muscle layers)
Deep soft tissue (fascia & muscle)
Deep incisional SSI
Superficial incisional SSI
Mangram AJ et al. Infect Control Hosp Epidemiol. 1999;20:250-278.
Organ/Space SSI
Infection occurs within 30 days after the operation if no implant is left in place or within 1 year if implant is in place and the infection appears to be related to the operation and the infection involves any part of the anatomy, other than the incision, which was opened or manipulated during the operation
Deep incisional SSI
Superficial incisional SSI
Organ/space SSIOrgan/space
Mangram AJ et al. Infect Control Hosp Epidemiol. 1999;20:250-278.
Cross Section of Abdominal Wall Depicting CDC SSI Classifications
Source of SSI Pathogens
• Endogenous flora of the patient
• Operating theater environment
• Hospital personnel (MDs/RNs/staff)
• Seeding of the operative site from distant
focus of infection (prosthetic device,
implants)
SSI Risk Factors
• Age
• Obesity
• Diabetes
• Malnutrition
• Prolonged preoperative stay
• Infection at remote site
• Systemic steroid use
• Nicotine use
• Hair removal/Shaving
• Duration of surgery
• Surgical technique
• Presence of drains
• Inappropriate use of antimicrobial prophylaxis
Microbiology of SSIs
Staphylococcusaureus17%
Coagulase neg.staphylococci
12%
Escherichiacoli10%
Enterococcusspp.8%
Pseudomonasaeruginosa
8%
Staphylococcusaureus20%
Coagulase neg.staphylococci
14%
Escherichiacoli8%
Enterococcusspp.12%
Pseudomonasaeruginosa
8%
1986-1989(N=16,727)
1990-1996(N=17,671)
National Nosocomial Infections Surveillance System (NNIS)
Classification Wound Class SSI Risk
Clean 0Lower
Higher
Clean-contaminated:GI/GU tracts entered in a controlled manner
1
Contaminated: open, fresh, traumatic wounds
infected urine, bile
gross spillage from GI tract
2
Dirty-infected:3
NNIS- SSI Surveillance 1992-2004
Cesarean Section
Risk Index Number of hospitals
Pooled mean ratePer 100 operations
Median- 50% percentile
0 130 2.71 2.17
1 117 4.14 3.19
2,3 51 7.53 5.38
Am J Infect Control 2004;32:470-85
Preventing Surgical Site Infections
Focus on modifiable risk factors
Sources of SSIs
• Endogenous: patient’s skin or mucosal flora– Increased risk with devitalized tissue, fluid
collection, edema, larger inocula• Exogenous
– Includes OR environment/instruments, OR air, personnel
• Hematogenous/lymphatic: seeding of surgical site from a distant focus of infection– May occur days to weeks following the procedure
• Most infections occur due to organisms implanted during the procedure
Downloaded from: Principles and Practice of Infectious Diseases
© 2004 Elsevier
Up to 20% of skin-associated bacteria in skin appendages (hair follicles, sebaceous glands) & are not eliminated by topical antisepsis. Transection of these skin structures by surgical incision may carry the patient's resident bacteria deep into the wound and set the stage for subsequent infection.
Risk Factors for SSI• Duration of pre-op hospitalization * increase in endogenous reservoir• Pre-op hair removal * esp if time before surgery > 12 hours * shaving>>clipping>depilatories• Duration of operation *increased bacterial contamination * tissue damage * suppression of host defenses * personnel fatigue
SCIP Performance Measures
Surgical infection prevention
• SSI rates• Appropriate prophylactic antibiotic chosen• Antibiotic given within 1 hour before incision• Discontinuation of antibiotic within 24 hours of surgery
• Glucose control• Proper hair removal• Normothermia in colorectal surgery patients
Downloaded from: Principles and Practice of Infectious Diseases
Infe
ctio
n R
ate
Process Indicators:
Duration of Antimicrobial Prophylaxis
Prophylactic antimicrobials should be discontinued within 24 hrs after the end of surgery
Bratzler DW et al. Clin Infect Dis 2004;38:1706-15.
Process Indicators:
Timing of First Antibiotic Dose
Infusion should begin within 60 minutes of the incision
Bratzler DW et al. Clin Infect Dis 2004;38:1706-15.
URINARY TRACT INFECTIONS
Importance of CAUTI
• Most common type of healthcare-associated infection
• > 30% of HAIs reported to NHSN • Estimated > 560,000 nosocomial UTIs
annually • Increased morbidity & mortality
43
Hidron AI et al. ICHE 2008;29:996-1011 Givens CD, Wenzel RP. J Urol 1980;124:646-8 Klevens RM et al. Pub Health Rep 2007;122:160-6 Green MS et al. J Infect Dis 1982;145:667-72 Weinstein MP et al. Clin Infect Dis 1997;24:584-602 Foxman B. Am J Med 2002;113:5S-13S Cope M et al. Clin Infect Dis 2009;48:1182-8 Saint S. Am J Infect Control 2000;28:68-75
Catheter-Urinary infection
• Health care-associated infections (HAIs) are one of the most common complications of hospital care.
44
Importance
• Catheter-associated (CA) bacteriuria is the most common health care–associated infection worldwide and
• a result of the widespread use of urinary catheterization, much of which is inappropriate, in hospitals and longterm care facilities (LTCFs).
45
• The most effective way to reduce the incidence of CA-ASB and CA-UTI is to reduce the use of urinary catheterization by restricting its use to patients who have clear indications and by removing the catheter as soon as it is no longer needed
46
• Strategies to reduce the use of catheterization have been shown to be effective and are likely to have more impact on the incidence of CA-ASB and CA-UTI than any of the other strategies addressed in these guidelines
47
• CA-UTI in patients with indwelling urethral, indwelling suprapubic, or intermittent catheterization is defined by the presence of symptoms or signs compatible with UTI with no other identified source of infection along with 103 colony-forming units (cfu)/mL of 1 bacterial species in a single catheter urine specimen
48
Catheter-associated Urinary Tract Infection (CAUTI)
• Single most common healthcare-associated infection (HAI), accounting for 34% of all HAIs.
• Associated with significant morbidity and excess healthcare costs.
• Since 2008, CMS no longer reimburses for additional costs required to treat CAUTIs.
CDC Surveillance Definition of CAUTI
A urinary tract infection that occurs while a patient has an indwelling urinary catheter or within 48 hours of its removal. Source: Dennis G. Maki and Paul A. Tambyah.
Engineering Out the Risk of Infection with Urinary Catheters. Emerg Infect Dis, Vol. 7, No. 2, March-April 2001.
Evidence-Based GuidelinesSince 2008, multiple evidence-based guidelines for
CAUTI prevention have been published
1980 1990 2000 2010
CDC JBI
NHS
NHS SHEA APIC NHSN* CDC IDSA
CDC= US Centers for Disease ControlJBI=Joanna Briggs InstituteNHS=UK National Health ServiceSHEA=Society of Healthcare Epidemiologists of AmericaAPIC=Association of Professionals of Infection ControlNHSN=CDC’s National Healthcare Safety Network (*revised surveillance definition)IDSA=Infectious Diseases Society of America
Importance of CAUTI
• Estimated 13,000 attributable deaths annually
• Leading cause of secondary BSI with ~10% mortality
• Excess length of stay –2-4 days • Increased cost – $0.4-0.5 billion per year
nationally • Unnecessary antimicrobial use
52
Catheterization rate• 15-25% of hospitalized patients • 5-10% (75,000-150,000) NH residents • Often placed for inappropriate indications • Physicians frequently unaware • In a recent survey of U.S. hospitals:
– > 50% did not monitor which patients catheterized – 75% did not monitor duration and/or
discontinuation
Weinstein JW et al. ICHE 1999;20:543-8 Munasinghe RL et al. ICHE 2001;22:647-9 Warren JW et al. Arch Intern Med 1989;149:1535-7 Saint S et al. Am J Med 2000;109:476-80 Benoit SR et al. J Am Geriatr Soc 2008;56:2039-44 Jain P et al. Arch Intern Med 1995;155:1425-9 Rogers MA et al J Am Geriatr Soc 2008;56:854-61 Saint S. et al. Clin Infect Dis 2008;46:243-50
Pathogenesis
54
• Formation of biofilms by urinary pathogens common on the surfaces of catheters and collecting systems
• Bacteria within biofilms resistant to antimicrobials and host defenses
• Some novel strategies in CAUTI prevention have targeted biofilms
Scanning electron micrograph of S. aureus bacteria on the luminal surface of an indwelling catheter with interwoven complex matrix of extracellular polymeric substances known as a biofilm
Catheter-associated Urinary Tract Infection (CAUTI)
• Urinary catheters are often placed unnecessarily, in place without physician awareness and not removed promptly when no longer needed.
• Prolonged catheterization is the #1 risk for catheter-associated urinary tract infection.
55
Complications of CAUTI’s:• Cystitis• Pyelonephritis• Prostititis• Endocarditis• Sepsis/Septic shock• Meningitis
(Lo, E; Nicolle, L; Classen, D; Arias, A M; Podrgorny, K; Deverick, J A; Burstin, H; Calfee, D; Coffin, S E; Dubberke, E R; Frasier, V; Gerding, D N; Griffin, F A; Gross, P; Kaye, K S; Klompas, M; Marschall, J; Mermel, L A; Pegues, D A; Perl, T M; Saint, S; Salgado, C D; Weinstein, R A; Deborah, S, 2008)
• Patient has at least 2 of the following signs or symptoms with no other recognized cause: fever (38.8C), urgency, frequency, dysuria, or suprapubic tenderness
• and at least 1 of the following
HAI-UTI
• positive dipstick for leukocyte esterase and/ or nitrate • pyuria (urine specimen with >10 white blood cell
[WBC]/mm or >3 WBC/highpower field of unspun urine)
• organisms seen on Gram’s stain of unspun urine • at least 2 urine cultures with repeated isolation of the
same uropathogen (gram negative bacteria or Staphylococcus saprophyticus) with >10 colonies/mL in non voided specimen.
HAI-UTI
Bacteria entry Urinary sampling from catheter
Nosocomial Bloodstream Infections
Nosocomial Bloodstream Infections, 1995-2002
Rank Pathogen Percent
1 Coagulase-negative Staph 31.3%
2 S. aureus 20.2%
3 Enterococci 9.4%
4 Candida spp 9.0%
5 E. coli 5.6%
6 Klebsiella spp 4.8%
7 Pseudomonas aeruginosa 4.3%
8 Enterobacter spp 3.9%
9 Serratia spp 1.7%
10 Acinetobacter spp 1.3%
N= 24,84752 BSI/10,000 admissions
Edmond M. SCOPE Project.
Nosocomial Bloodstream Infections, 1995-2002
Edmond M. SCOPE Project.
•Proportion of all BSI 0.9% (n=209)
•E.coli (33%)
•S.aureus (11.7%)
•Enterococci (11.7)
Obstetrics and Gynecology
In obstetrics, BSIs are uncommon. However, the principal pathogen is E.coli and not coagulase negative staphylococci.
The source is typically genitourinary
N= 24,84752 BSI/10,000 admissions
Nosocomial Bloodstream Infections
• 12-25% attributable mortality
• Risk for bloodstream infection:BSI per 1,000 catheter/days
Subclavian or internal jugular CVC 5-7
Hickman/Broviac (cuffed, tunneled) 1
PICC 0.2 - 2.2
Risk Factors for Nosocomial BSIs
• Heavy skin colonization at the insertion site
• Internal jugular or femoral vein sites
• Duration of placement
• Contamination of the catheter hub
Prevention of Nosocomial BSIs
• Coated catheters– In meta-analysis C/SS catheter decreases BSI
(OR 0.56, CI95 0.37-0.84)– M/R catheter may be more effective than C/SS– Disadvantages: potential for development of
resistance; cost (M/R > C/SS > uncoated)
• Use of heparin– Flushes or SC injections decreases catheter
thrombosis, catheter colonization & may decrease BSI
Prevention of Nosocomial BSIs
• Limit duration of use of intravascular catheters– No advantage to changing catheters routinely
• Change CVCs to PICCs when possible• Maximal barrier precautions for insertion
– Sterile gloves, gown, mask, cap, full-size drape– Moderately strong supporting evidence
• Chlorhexidine prep for catheter insertion
30%-40% of all Nosocomial Infections are Attributed to Cross Transmission- Implication For The Spread Drug Resistant Pathogens
Fig 1. Selected antimicrobial-resistant pathogens associated with nosocomial infections in ICU patients, comparison of resistance rates from January through December 2003 with 1998 through 2002, NNIS System.
Am J Infect Control 2004;32:470-85
NNIS: Selected antimicrobial resistant pathogens associated with HAIs
Health-Care Associated (Nosocomial) PneumoniaHealth-Care Associated
(Nosocomial) Pneumonia
Definition
Occurring at least 48 hours after admission and not incubating at the time of hospitalization
Introduction
• Nosocomial pneumonia is the 2nd most common hospital-acquired infections after UTI. Accounting for 31 % of all nosocomial infections
• Nosocomial pneumonia is the leading cause of death from hospital-acquired infections.
• The incidence of nosocomial pneumonia is highest
in ICU.
Introduction
• The incidence of nosocomial pneumonia in ventilated patients was 10-fold higher than non-ventilated patients
• The reported crude mortality for HAP is 30% to greater than 70%.
--- Medical Clinics of North America Therapy of Nosocomial pneumonia 2001 vol.85 1583-94
PathogenesisPathogenesis
Pathogenesis
• For pneumonia to occur, at least one of the following three conditions must occur:
1. Significant impairment of host defenses
2. Introduction of a sufficient-size inoculum to overwhelm the host's lower respiratory tract defenses
3. The introduction of highly virulent organisms into the lower respiratory tract
• Most common is microaspiration of oropharyngeal secretions colonized with pathogenic bacteria.
Pathogenesis
--- The Prevention of Ventilator-Associated Pneumonia Vol.340 Feb 25, 1999 NEJM
Classification
• Early-onset nosocomial pneumonia: Occurs during the first 4 days Usually is due to S. pneumoniae, MSSA, H. Influenza,
or anaerobes.• Late-onset nosocomial pneumonia: More than 4 days More commonly by G(-) organisms, esp. P. aeruginosa, Acinetobacter, Enterobacteriaceae (klebsiella,
Enterobacter, Serratia) or MRSA.
Causative Agent
• Enteric G(-) bacilli are isolated most frequently particularly in patients with late-onset disease and in patients with serious underlying disease often already on broad-spectrum antibiotics.
• Prior use of broad-spectrum antibiotics and an immunocompromised state make resistant gram-negative organisms more likely.
Causative Agent
• P. aeruginosa and Acinetobacter are common causes of late-onset pneumonia, particularly in the ventilated patients.
Causative Agent
• S. aureus is isolated in about 20~40% of cases and is particularly common in :
1. Ventilated patients after head trauma, neurosurgery, and wound infection
2. In patients who had received prior antibiotics or Prolonged care in ICU
• MRSA is seen more commonly in patients Received corticosteroids Undergone mechanical ventilation >5 days Presented with chronic lung disease Had prior antibiotics therapy
Causative Agent• Anaerobes are common in patients predisposed to
aspiration
• VAP with anaerobes occurred more often with oropharyngeal intubation than nasopharyngeal intubation.
Causative Agent• Legionella pneumophilia occurs sporadically but may be
endemic in hospitals with contaminated water systems. The incidence is underestimated because the test to identify Legionella are not performed routinely.
• Because the incubation period of Legionella infection is 2 to 10 days. cases that occur more than 10 days after admission are considered to be nosocomial, and cases that develop between 4 and 10 days are considered as possible nosocomial.
• Patients who are immunocompromised, critically ill, or on steroids are at highest risk for infection.
Antimicrobial Resistant Pathogens of Ongoing Concern
• Vancomycin resistant enterocci– 12% increase in 2003 when compared to 1998-2002
• MRSA– 12% increase in 2003 when compared to 1998-2002– Increased reports of Community-Acquired MRSA
• Cephalosporin and Imipenem resistant gram negative rods– Klebsiella pneumonia– Pseudomonas aeruginosa
Am J Infect Control 2004;32:470-85
Transfer of VRE via HCW Hands
Duckro et al. Archive of Int Med. Vol.165,2005
16 transfers (10.6%) occurred in 151 opportunities.
•13 transfers occurred in rooms of unconscious patients who were unable to spontaneously touch their immediate environment
The inanimate environment is a reservoir of pathogens
~ Contaminated surfaces increase cross-transmission ~
Abstract: The Risk of Hand and Glove Contamination after Contact with a VRE (+) Patient Environment. Hayden M, ICAAC, 2001, Chicago, IL.
X represents a positive Enterococcus culture
The pathogens are ubiquitous
The inanimate environment is a reservoir of pathogens
Recovery of MRSA, VRE, C.diff CNS and GNR
Devine et al. Journal of Hospital Infection. 2001;43;72-75
Lemmen et al Journal of Hospital Infection. 2004; 56:191-197
Trick et al. Arch Phy Med Rehabil Vol 83, July 2002
Walther et al. Biol Review, 2004:849-869
The inanimate environment is a reservoir of pathogens
Recovery of MRSA, VRE, CNS. C.diff and GNR
Devine et al. Journal of Hospital Infection. 2001;43;72-75
Lemmen et al Journal of Hospital Infection. 2004; 56:191-197
Trick et al. Arch Phy Med Rehabil Vol 83, July 2002
Walther et al. Biol Review, 2004:849-869
The inanimate environment is a reservoir of pathogens
Recovery of MRSA, VRE, CNS. C.diff and GNR
Devine et al. Journal of Hospital Infection. 2001;43;72-75
Lemmen et al Journal of Hospital Infection. 2004; 56:191-197
Trick et al. Arch Phy Med Rehabil Vol 83, July 2002
Walther et al. Biol Review, 2004:849-869
Alcohol based hand hygiene solutionsQuick Easy to use
Very effective antisepsis due to bactericidal properties of alcohol
Hand Hygiene
• Single most important method to limit cross transmission of nosocomial pathogens
• Multiple opportunities exist for HCW hand contamination– Direct patient care
– Inanimate environment
• Alcohol based hand sanitizers are ubiquitous– USE THEM BEFORE AND AFTER PATIENT
CARE ACTIVITIES
Contact Precautions for drug resistant pathogens.
Gowns and gloves must be worn upon entry into the patient’s room
Biofilms
• Biofilms are microbial communities (cities) living attached to a solid support eg catheters/ other medical devices
• Biofilms are involved in up to 60% of nosocomial infections
• Antibiotics are less effective at killing bacteria when part of a biofilm
Transmission
1. Contact – most common• Direct (physical contact)
• Indirect (via contaminated objects)
2. Airborne Transmission• Droplet respiratory secretions on surfaces
• Inhalation of infectious particles
3. Blood-borne transmission
4. Food-borne
Role of infection control teams
• Education and training
• Development and dissemination of infection control policy
• Monitoring and audit of hygiene
• Clinical audit
Isolation & barrier precautions
Decontamination of equipment
Prudent use of antibiotics
Hand washing
Decontamination of environment
Surveillance
• Continuous monitoring of the frequency and distribution of infectious diseases
• Determines the most important causes of infectious diseases and identifies at risk groups
Uses of surveillance
• Used to identify new “problems”
• Used to identify where resources are most needed
• Used to determine the burden of disease
• Used for strategic planning and policies
• Use surveillance for measuring outcomes of intervention strategies
INFECTIOUS AGENTBacteria - Fungi -Viruses Rickettsiae – Protozoal
Prions – Protozoa Helminths
RESERVOIRSPeople
EquipmentEnvironment
Water
SUSCEPTIBLE HOSTImmunosuppression
Diabetes – Surgery – BurnsCardiopulmonary -
Neonates
PORTAL OF ENTRY
Mucous membrane GI / urinary / Respiratory track
Broken skin
PORTAL OF EXITExcretions - Secretions
Skin - Droplets
MEANS OF TRANSMISSION
Direct Contact Fomites
- Injection / Ingestion - Airborne aerosol
MEANS OF TRANSMISSION
Direct Contact Fomites
- Injection / Ingestion - Airborne aerosol
HEALTH CARE WORKERS
Air flow control
Food handling
Isolation
Trash & waste
disposal
Control of excretions
and secretions
Hand-hygiene
Disinfection/sterilization
Environmental sanitation
Employee health Care
Rapid accurate identification of
organismTreatment of underlying disease
Recognition of high risk patients
Aseptic Technique
Catheter Care
Wound Care
Hand-hygiene
Sterilization
Aşağıdaki ameliyat tiplerinin hangisinde cerrahi alan enfeksiyonu en fazla görülür?
A) Kolesistektomi
B) Tiroidektomi
C) Memeden kitle eksizyonu
D) Kolon rezeksiyonu
E) İnguinal herni ameliyatı
TUS 2010
Aşağıdaki ameliyat tiplerinin hangisinde cerrahi alan enfeksiyonu en fazla görülür?
A) Kolesistektomi
B) Tiroidektomi
C) Memeden kitle eksizyonu
D) Kolon rezeksiyonu
E) İnguinal herni ameliyatı