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Page 1 of 16 This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184 Copyright © 2015, SAPHIR Consortium Horizon 2020 Programme SFS-01b-2014 Tackling losses from terrestrial animal diseases Strengthening Animal Production and Health through the Immune Response Project ID: 633184 Deliverable number : D17.2 Deliverable title : Project website on-line EC version : V1 Due date of deliverable 31/03/2015 (M1) Actual submission date 02/07/2015 (M5)

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Page 1: Horizon 2020 Programme SFS-01b-2014 · Horizon 2020 Programme SFS-01b-2014 ... Project structure (sub page) ... New vaccine platforms: new generation of DNA vaccines and viral replicon

Page 1 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

Horizon 2020 Programme

SFS-01b-2014

Tackling losses from terrestrial animal diseases

Strengthening Animal Production and Health through the Immune Response

Project ID: 633184

Deliverable number : D17.2

Deliverable title : Project website on-line

EC version : V1

Due date of deliverable 31/03/2015 (M1)

Actual submission date 02/07/2015 (M5)

Page 2: Horizon 2020 Programme SFS-01b-2014 · Horizon 2020 Programme SFS-01b-2014 ... Project structure (sub page) ... New vaccine platforms: new generation of DNA vaccines and viral replicon

Page 2 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

DOCUMENT INFO

1. Author(s)

Organisation name lead contractor EFFAB

Author Organisation e-mail

Miriam van Straten EFFAB [email protected]

Eline Raedts EFFAB [email protected]

2. Revision history

Version Date Modified by Comments

1 Final version

3. Dissemination level

PU Public

CO Confidential, only for members of the consortium (excluding the Commission Services)

Page 3: Horizon 2020 Programme SFS-01b-2014 · Horizon 2020 Programme SFS-01b-2014 ... Project structure (sub page) ... New vaccine platforms: new generation of DNA vaccines and viral replicon

Page 3 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

EXECUTIVE SUMMARY

Background

The SAPHIR website is a dynamic medium which will be adapted during the

course of the project. News, events and project results will be added over

time. The website is an important first contact point of the project with the

target audiences. It should be informative, up-to-date, inspiring and inclusive,

and invite visitors to further engage with the project.

The project website is available on http://www.h2020-saphir.eu

The website is set up to cover the following content:

- Project aim, objectives, description and impact

- News items and press releases

- Agenda of important public events regarding the project

- Description and contact details about partners and collaborators in-

volved in the project

- Links to related national and EU projects

- Public project results

- Secure area for project partners and dedicated stakeholders

Objectives To communicate up-to-date information the project, the partners involved, the background of the project and on the project activities, the outcomes and the meaning of the outcomes.

Methods A website will be made using the web-hosting service ‘Weebly’, with an online website creator. Information will be gathered from all the other work-packages.

Page 4: Horizon 2020 Programme SFS-01b-2014 · Horizon 2020 Programme SFS-01b-2014 ... Project structure (sub page) ... New vaccine platforms: new generation of DNA vaccines and viral replicon

Page 4 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

Results

& implications

A SAPHIR dedicated website that will inform project members, stakeholders and the wider public about project activities. It will serve as an important first contact point for the targeted audience.

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Page 5 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

Table of contents

1. General outline of the website ....................................................................................................... 6

2. Details webpages ......................................................................................................................... 7

a. Home page: general project information .................................................................................... 7

b. Project ....................................................................................................................................... 9

c. News & Events ........................................................................................................................ 13

d. Partners .................................................................................................................................. 13

e. Links ........................................................................................................................................ 14

f. Knowledge .............................................................................................................................. 14

g. Secure area ............................................................................................................................. 15

3. Screenshots ................................................................................................................................ 15

Page 6: Horizon 2020 Programme SFS-01b-2014 · Horizon 2020 Programme SFS-01b-2014 ... Project structure (sub page) ... New vaccine platforms: new generation of DNA vaccines and viral replicon

Page 6 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

1. General outline of the website

Home

Project

o Objectives

o Ambition

o Impact

o Project structure

Pillar A

Pillar B

Pillar C

Pillar D

Pillar E

o Pathogens

News & Events

o News

o Events

o Position offers from SAPHIR partners

Partners

Links

Knowledge

o SAPHIR Q&A

o Results

o Integrated Health Strategies

o Wiki vaccines

Secure area

+ Search function

+ Link to intranet for project partners

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Page 7 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

2. Details webpages

a. Home page: general project information

+ links to other SAPHIR webpages (news, events, etc))

"Strengthening Animal Production and Health through the Immune Response"

SAPHIR aims

The European research project SAPHIR aims to develop innovative, safe, affordable and effective

vaccine strategies effective against endemic pathogens responsible for high economic losses in live-

stock. By generating vaccine strategies for these pathogens in pigs, poultry and ruminants, SAPHIR

will aid in strengthening the profitability of food animal systems, improve animal welfare and reduce

xenobiotic usage in farming with a ‘One Health’ perspective

Targeted pathogens

SAPHIR has selected two representative pathogens of pigs (Porcine Reproductive and Respiratory

Syndrome Virus (PRRSV) and Mycoplasma hyopneumoniae), chickens (Eimeria and Clostridium

perfringens) and cattle (Bovine Respiratory Syncytial Virus (BRSV), Mycoplasma bovis) to develop

generic vaccine approaches applicable to other pathogens.

From research to practice

The SAPHIR dissemination and training programme includes creation of an integrated health man-

agement website, launch courses on Veterinary Vaccines and organization of workshops directed at

food animal system stakeholders. This will ensure optimal research translation of SAPHIR outputs to

market and field applications.

Interdisciplinary consortium

SAPHIR brings together interdisciplinary expertise from fourteen academic institutes including a Chi-

nese partner, five SMEs, one pharmaceutical company and a forum of animal breeders.

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This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

Contact us:

Isabelle Schwartz-Cornil, project coordinator

Institute National de la Recherche Agronomique

+33 13 46 526 43

[email protected]

Marie-Hélène Pinard, deputy coordinator

+33 13 46 521 84

Institute National de la Recherche Agronomique

[email protected]

Project information:

SAPHIR is a Horizon 2020 project running from 1 March 2015 to28 February 2019. This research re-

ceived funding from the European Union’s Horizon 2020 research and innovation programme under

agreement No 633184. The contribution of the European Commission is €9 million. The project re-

ceived €1.7 million from the swiss government.

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Page 9 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

b. Project

To show the potency of promising vaccines against frequently occurring pathogens (see table) and to

design innovative vaccine strategies, resulting in an increased viability, sustainability and profitability

of food animal production systems and an improved animal welfare.

Objectives (sub page)

Scientific objectives:

To unravel mechanisms of immune protection, induce rapid and long-lasting immunity, develop save

vaccines and predict epidemiological consequences of vaccination.

Technical objectives:

To generate models and assays for the development of vaccines, to investigate a variety of vaccines

and delivery systems and to bring promising vaccines to demonstration.

Socio-economic objectives:

To explore the economic impact of the SAPHIR diseases and to predict the socio-economic benefits of

using the designated vaccination strategies.

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Page 10 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

Ambition (sub page)

Tackle current vaccine weaknesses and provide effective vaccine-based strategies.

Five core elements to achieve this goal:

- Understanding the socio-economic drivers of vaccine use at field level

- Develop a generic approach that can be translated to a large array of pathogens

- Delivery of vaccines close to market positioning and vaccine strategies to be applied

- Optimize the route to market and vaccine use

- Gathering an outstanding multi-disciplinary network of experts

Impact (sub page)

By generation of innovative vaccine strategies SAPHIR will minimize public health risks by preventing

and controlling animal diseases and reducing the use of antibiotics in the ‘one health’ perspective. A

decrease in animal diseases and anti-microbial use will result in an improved animal welfare and

therefore will increase productivity, efficiency and profitability of animal agriculture.

By identification of markers that can be used for selective breeding, robust animals that are better

adapted to environmental changes and exhibit an optimal response to vaccination can be selected.

The SAPHIR project will formulate new efficiency traits for these breeding programmes.

Concerns about food safety and the use of GMO vaccines are high. Therefore, the SAPHIR project

will contribute to improve the livestock producers’ acceptance and use of vaccines.

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Page 11 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

Knowledge and technology that arise from the SAPHIR project will be exploited in the following mar-

kets:

- Veterinary vaccine market

- Animal diagnostic company market

- Livestock breeding and selection market

- Animal protein sector

Results of the SAPHIR project will be disseminated to reach these stakeholders and to promote vac-

cine developments by companies.

Project structure (sub page)

Pillar A: Socio-economic context analysis of the SAPHIR diseases and their control measures.

WP1. Economic analysis of the SAPHIR diseases and their existing control measures, including vac-

cination.

WP2. Identification of the sociological pathways for SAPHIR diseases.

Pillar B: Development of pathogen-specific vaccine strategies.

WP3. Development of novel adaptable attenuated PRRSV marker vaccines.

WP4. Development of a M. hyopneumoniae attenuated vaccine and improvement of bacterin vaccine.

WP5. Eimeria: understanding protective immunity and development as vaccine vectors.

WP6. The use of Eimeria and Bacillus strains expressing C. perfringens antigens to prevent necrotic

enteritis in broilers.

WP7. Development of DIVA BRSV vaccines.

WP8. Development of a M. bovis subunit-vaccine using a reverse vaccinology approach.

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This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

Pillar C: Development of generic vaccine strategies.

WP9. Improving vaccine adjuvants by targeted stimulation of dendritic cells.

WP10. New vaccine platforms: new generation of DNA vaccines and viral replicon particles.

WP11. Optimizing mucosal and skin delivery.

WP12. Understanding and improvement of age-dependent vaccines response.

WP13. Individual variability of immunocompetence: search for markers predictive of vaccine respons-

es.

Pillar D: Strategies to translate SAPHIR research into the market and into the field.

WP14. From laboratory to the market (demonstration).

WP15. Socio-economic evaluation of the SAPHIR strategies.

WP16. Prediction of vaccine effectiveness in the field.

Pillar E / WP17: Outreach, dissemination and training.

Pillar F / WP18: Management.

Pathogens (sub page)

On this web page, more specific information can be presented on the pathogens that

are addressed by SAPHIR. Contents to be filled in later.

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This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

c. News & Events

News (sub page; including side bar with shortlist events)

- At May 11-13th 2015, the SAPHIR kick-off meeting took place in Jouy-en-Josas, France.

Delegates from the 22 different partners encaged in the SAPHIR project met each other and

discussed the various goals set for this project.

Events (sub page)

- Annual SAPHIR meetings

- Workshops

- Training

- Etc.

d. Partners

1. Institut National de la Recherche Agronomique

2. Cardiff University

3. Eidgenössisches Departement des Innern, Institut für Virologie

und Immunologie

4. European Forum of Farm Animal Breeders

5. Immunología y Genética Aplicada S.A. Ingenasa

6. INRA Transfer

7. Parco Tecnologico Padano

8. Shanghai Veterinary Research Institute

9. SporeGen

10. Stichting Dienst Landbouwkundig Onderzoek - Central Veteri-

nary Institute

11. Sveriges Lantbruksuniversitet

12. Warsaw University of Life Sciences

13. The Pirbright Institute

14. The Royal Veterinary College – University of London

15. Bern University

16. Lausanne University

17. Universiteit Gent

18. University Court of the University of Edinburgh

19. Vaccibody

20. Virbac

21. Xeolas Pharmaceuticals

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This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

e. Links PARAGONE

Feed-a-gene

Mycosynvac

PROHEALTH

STAR-IDAZ

RISKSUR

NEAT

DISCONTOOLS

PoRRSCON

PREDEMICS

Animal task force

ARIIS

NADIR

Transvac

RAPIDIA-FIELD

ASFORCE

Eurowestnile

One Health

f. Knowledge

SAPHIR Q&A (sub page)

On the SAPHIR Q&A page, some general question on subjects related to the pathogens and

vaccinations can be presented, aimed at the general public.

Results (sub page)

On this page, the public results from SAPHIR can be presented, like titles of publications and

communications.

Integrated Health Services

On this page, the Integrated Health Services website can be presented/ introduced, with a link

to the actual website once it is online.

Wiki vaccines

On this page the wiki-website resulting from the project can be presented, with a link to the ac-

tual website once it is online.

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This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium

g. Secure area

Contents to be decided later.

3. Screenshots Below some screenshots to present the look and lay-out of the SAPHIR website

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Page 16 of 16

This project has received funding from the European Union’s Horizon 2020 Programme for research, technological development and demonstration under the Grant Agreement n°633184

Copyright © 2015, SAPHIR Consortium