holliday model .. genetics chromosomal structural changes
TRANSCRIPT
HOLLIDAY MODEL
The Holliday model
Two homologous duplexes are aligned
Strand exchange leads to an intermediate with crossed strands
This branch can move: Branch migration
The branch is resolved by cleavage and sealingHeteroduplexes: minor base sequence differences b/w homologous chr.
A DNA double helix formed by annealing single strands from different sources; if there is a sequence difference between the strands, the heteroduplex may show single strand loops or bubbles (unpaired regions).
The cross-strand Holliday structure is an The cross-strand Holliday structure is an intermediate in recombination intermediate in recombination
The cross-strand Holliday structure is an The cross-strand Holliday structure is an intermediate in recombination intermediate in recombination