Allele Gene frequencyB*51 0.108B*52 0.023B*53 0.046B*54 0B*55 0B*56 0B*57 0B*58 0.146B*59 0B*67 0B*73 0B*78 0B*81 0Cw*01 0.015Cw*02 0.008Cw*0302 0.121Cw*0303 0.015Cw*04 0.22Cw*05 0Cw*0602 0.061Cw*0701 0.152Cw*0702 0.045Cw*0703 0Cw*0704 0Cw*0801 0.015Cw*0802 0Cw*1202 0.03Cw*1203 0.045Cw*14 0.03Cw*15 0.189Cw*1601 0.008Cw*1602 0.008Cw*17 0.038DQB1*02 0.396DQB1*0301 0.075DQB1*0302 0.028DQB1*030302 0DQB1*0305 0.009DQB1*04 0.009DQB1*05 0.34DQB1*06 0.142DRB1*01 0.151DRB1*03 0.396DRB1*04 0.009DRB1*07 0.019DRB1*08 0.009DRB1*09 0DRB1*1001 0.019DRB1*11 0.122DRB1*12 0DRB1*13 0.028DRB1*1302 0DRB1*14 0.019DRB1*15 0.094DRB1*16 0.132

Haplotypes Frequency (%)A*11-B*35 7A*11-B*35-Cw*04 7.1A*11-B*35-DRB*01 3.8A*11-B*40 9.5A*11-B*40-Cw*04 3.1A*11-B*40-Cw*15 5.4A*11-B*40-DRB*16 3.8A*2601-B*08 5.4A*2601-B*08-Cw*0701 3A*2601-B*08-DRB*03 5.7A*3201-B*51 3.9A*3201-B*51-Cw*15 3.1A*3201-B*51-DRB*01 2.8A*33-B*51-DRB*03 2.2A*33-B*58 10.8A*33-B*58-Cw*03 11.1A*33-B*58-DRB*03 8.2B*08-Cw*0701 7.1B*35-Cw*04 10.3B*40-Cw*15 11.1B*51-Cw*15 5.5B*58-Cw*03 13.4DRB1*01-DQB1*05 11.2DRB1*03-DQB1*02 20.9DRB1*1001-DQB1*05 5.3DRB1*13-DQB1*06 11.2DRB1*15-DQB1*06 6.7DRB1*15-DQB1*0601 7.5

HLA-A, -B, -Cw, -DQB1 and

-DRB1 Allele Frequencies in a

Burusho Population from Pakistan

A. Mohyuddin*, S. Khaliq, Q. Ayuband S.Q. MehdiBiomedical and Genetic Engineering Laboratories,Islamabad, PakistanE-mail: *aishamoh@isb.comsats.net.pk

This population from northern Pakistan, Latitude 36–37NLongitude 73–75E consisted of 92 Caucasian individuals. Theindividuals were drawn from a rural environment where thegrandparents had also lived and alleles were determined usingsequence specific primers. The Burusho reside in the Hunza,Nagar and Yasin Valleys of the Karakoram Mountains innorthern Pakistan and they speak Burushaski which someconsider as one of the few remaining language isolates. TheBurusho claim to have possible origins from four generals inAlexander’s army. However, despite speaking an isolated lan-guage the Burusho genetically resemble their geographicalneighbours in Pakistan. The results have previously been pub-

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Human Immunology 65 (2004)0198-8859/04/$–see front matter© American Society for Histocompatibility and Immunogenetics, 2004

Published by Elsevier Inc.

lished in Tissue Antigens 59, 492–501, 2002 and TissueAntigens 61, 286–291, 2003. The following alleles could notbe distinguished A*0301/03N (frequency entered underA*0301) A*2402/09N/11N (entered under A*2402)Cw*0302/04 (entered under Cw*0302) Cw*0801/03 (enteredunder Cw*0801) DQB1*0301/04 (entered underDQB1*0301). Human Immunology 65, 1042–1044 (2004).© American Society for Histocompatibility and Immunoge-netics, 2004. Published by Elsevier Inc.

Allele Gene frequencyA*01 0.054A*0101 0.054A*0102 0A*02 0.125A*0201 0.054A*0202 0A*0203 0A*0204 0A*0205 0A*0206 0.06A*0207 0A*0208 0A*0209 0A*0210 0A*0211 0.011A*0212 0A*0213 0A*0214 0A*0215N 0A*0216 0A*0217 0A*0218 0A*0219 0A*0220 0A*0221 0A*0222 0A*0224 0A*0225 0A*0226 0A*0236 0A*03 0.13A*0301 0.13A*0302 0A*11 0.125A*1101 0.125A*1102 0A*1103 0A*1104 0A*23 0A*2301 0A*24 0.136A*2402 0.125A*24020102L 0A*2403 0.011A*2404 0A*2405 0A*2406 0A*2408 0A*2410 0

Allele Gene frequencyA*2413 0A*2414 0A*25 0A*2501 0A*2502 0A*26 0.098A*2601 0.098A*2602 0A*2605 0A*2606 0A*2607 0A*2608 0A*2609 0A*29 0.005A*2901 0.005A*2902 0A*30 0.016A*3001 0.005A*3002 0.011A*3003 0A*3004 0A*31 0.022A*310102 0.022A*32 0.027A*3201 0.027A*3202 0A*33 0.179A*3301 0A*3303 0.179A*34 0A*3401 0A*3402 0A*36 0A*3601 0A*43 0A*4301 0A*66 0A*6601 0A*6602 0A*6603 0A*6801 0.082A*680101 0A*680102 0.082A*6802 0A*6803 0A*6804 0A*6805 0A*69 0A*6901 0A*80 0A*8001 0

B*07 0.051B*0703 0B*08 0.153B*13 0.015B*14 0

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Allele Gene frequencyB*1401 0B*1402 0B*15 0.071B*18 0B*27 0.02B*35 0.204B*37 0.015B*38 0.005B*39 0.005B*40 0.01B*41 0.041B*42 0B*44 0.046B*45 0B*46 0B*47 0.005B*48 0.01B*4801 0.01B*4802 0B*49 0.01B*50 0.005B*51 0.179B*52 0.071B*53 0B*54 0B*55 0.01B*56 0B*57 0.015B*58 0.046B*67 0B*73 0B*78 0.005B*81 0

Cw*01 0.036Cw*02 0.036Cw*03 0.061Cw*04 0.133Cw*05 0.031Cw*06 0.051Cw*0602 0.051Cw*07 0.311Cw*0701 0.056Cw*0702 0.255Cw*0703 0Cw*0704 0Cw*0801 0.01Cw*0802 0Cw*12 0.209Cw*1202 0.102Cw*1203 0.107Cw*14 0.02Cw*15 0.046Cw*16 0.02Cw*1601 0Cw*1602 0.02Cw*17 0.036

Allele Gene frequency

DQB1*02 0.242DQB1*03 0.161DQB1*0301 0.048DQB1*0302 0.086DQB1*030302 0.011DQB1*0305 0.016DQB1*04 0.048DQB1*05 0.22DQB1*06 0.328

DRB1*01 0.118DRB1*03 0.237DRB1*04 0.048DRB1*07 0.032DRB1*08 0.07DRB1*09 0DRB1*10 0.065DRB1*1001 0.065DRB1*11 0.075DRB1*12 0DRB1*13 0.14DRB1*1302 0DRB1*14 0.043DRB1*15 0.172DRB1*16 0

Haplotype Frequency (%)A*02-B*41 4.1A*02-B*41-Cw*17 3.6A*03-B*35-DRB*01 3.8A*11-B*35 5.2A*11-B*35-Cw*04 3.6A*24-B*35 7.8A*24-B*35-DRB*15 5.5A*24-B*35-Cw*1203 6.6A*2601-B*08 5.2A*2601-B*08-DRB*03 4.7A*2601-B*08-Cw*0702 6A*33-B*08 5.9A*33-B*08-DRB*03 6.7A*33-B*08-Cw*0702 5.2A*33-B*58 4.6A*33-B*58-DRB*03 3.2A*33-B*58-Cw*03 4.6B*07-Cw*0702 5.1B*08-Cw*0702 14.8B*35-Cw*04 10.2B*35-Cw*1203 9.7B*52-Cw*12 5.6DRB1*01-DQB1*05 11.3DRB1*03-DQB1*02 21DRB1*1001-DQB1*05 5.4DRB1*13-DQB1*06 11.3DRB1*15-DQB1*06 6.8DRB1*15-DQB1*0601 7.5

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