Histology for PathologyHepatobiliary System

(Accessory Digestive Organs)

Silver Daniel, MDAssistant Professor

Theresa Kristopaitis, MDAssociate Professor

Director of Mechanisms of Human Disease

Kelli A. Hutchens, MD, FCAPAssistant Professor

Assistant Director of Mechanisms of Human Disease

Loyola Stritch School of Medicine

Hepatobiliary Histology

• On a low power H&E stained section outline a liver lobule.• Explain the rationale of dividing the hepatic acinus into three zones. • Identify the components of the portal triad/tract: portal vein,

hepatic artery, bile duct.• Identify hepatic sinusoids and describe the endothelium that lines

the sinusoids.• Define “Kupffer cells” and their function.• List the structures that form the space of Disse.• Describe the path of blood flow as it is filtered through the liver.• Describe the location of bile canaliculi and their function. • Describe the path of bile flow from the liver to the gallbladder.• Identify the three layers of the gallbladder: mucosa, muscularis and

serosa/adventitia.

Image courtesy of Robbins and Cotran Pathologic Basis of Disease, 7th edition

Image courtesy of www.apsu.edu

Image courtesy of Nature Reviews Immunology , March 2006

Biliary TractFlow of bile from liver

Image courtesy of Robbins and Cotran Pathologic Basis of Disease, 7th edition