histo on your nerves
DESCRIPTION
Histo On Your Nerves. SSN Histology October 26th, 2004 Missy Walker, [email protected] So Young Kim, [email protected]. So what’s in a nerve?. Dendrite. Axon Terminal. Perikaryon. Nucleus of myelin-producing cells. Node of Ranvier. Axon. Myelin-Producing Cell. Axon Hillock. - PowerPoint PPT PresentationTRANSCRIPT
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Histo On Histo On Your NervesYour Nerves
SSN HistologySSN Histology
October 26th, 2004October 26th, 2004
Missy Walker, [email protected] Walker, [email protected]
So Young Kim, [email protected] Young Kim, [email protected]
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Node of Ranvier
Perikaryon
Myelin-Producing Cell
So what’s in a nerve? So what’s in a nerve?
Axon Hillock
Dendrite
Axon Terminal
Axon
Nucleus of myelin-producing cells
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Axon vs. DendriteAxon vs. Dendrite
Axon DendriteNONO Synthetic Synthetic Machinery! Machinery!
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Nervous System ClassificationsNervous System Classifications
Nervous System
CNS PNS
Spinal Cord Cerebellum Cerebral Cx ANS Somatic Enteric (Ganglia) (Peripheral Nerve)
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Spinal CordSpinal Cord
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Spinal Cord: White MatterSpinal Cord: White Matter
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Myelin Production in CNSMyelin Production in CNS
Oligodendrocytes
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Spinal Cord Gray MatterSpinal Cord Gray Matter
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Spinal CordSpinal Cord
Cajal’s Silver
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MeningesMeninges
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AstrocytesAstrocytes
No collagen in the CNS!!! No collagen in the CNS!!!
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BrainBrain
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CerebellumCerebellum
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CerebellumCerebellum
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Purkinje CellPurkinje Cell
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Cerebral CortexCerebral Cortex
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Cerebral CortexCerebral Cortex
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Cerebellum vs. Cerebral CxCerebellum vs. Cerebral Cx
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Cerebellum vs. Cerebral CortexCerebellum vs. Cerebral Cortex
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Pyramidal Cells vs. Spinal Cord Gray Pyramidal Cells vs. Spinal Cord Gray MatterMatter
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Peripheral Nervous System (PNS)Peripheral Nervous System (PNS) Nervous tissue outside of the brain and spinal cordNervous tissue outside of the brain and spinal cord
Somatic Nervous System
• Innervates skeletal muscle
• For conscious movement
• Cell bodies in CNS
Autonomic Nervous System
• Innervates smooth muscle and glands
• For organ function and regulation
• Cell bodies in CNS and PNS
Sympathetic & Parasympathetic
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ANS - GangliaANS - Ganglia
Sympathetic GANGLIA in thorax contain:
• neuronal cell bodies
• satellite cells (support cells of the neuron)
Synapses occur
• Presynaptic fibers myelinated
• Postsynaptic fibers unmyelinated
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Enteric NS - GangliaEnteric NS - Ganglia
Myenteric plexus in ENS
• Within Smooth Muscle of Gut
• NO Collagen (as in CNS)
• Glial cells (no Schwann cells)
• Nuclei are euchromatic
• Gut has “mind of its own”
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ENS Ganglion vs ANS Ganglion ENS Ganglion vs ANS Ganglion
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Cross section of nerveCross section of nerve
Organization by
Connective Tissues
• Endoneurium collagen fibers associated with individual neurons -Schwann cells within
• Perineurium layer(s) of connective tissue cells, create fascicles
• Epineurium dense cnxtive tissue binding fascicles into a bundle
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Peripheral nervePeripheral nerve
• Epineurium
• Perineurium
• Endoneurium
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Periph nerve Periph nerve - longitudinal section- longitudinal section
• Endoneurium• Perineurium• Epineurium
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Longitudinal Section – Cajal stainLongitudinal Section – Cajal stain
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Peripheral Nerve – High Power (Cajal)Peripheral Nerve – High Power (Cajal)
• Nodes of Ranvier• Neurilemma
(cytoplasm of Schwann cells)
• What’s the black?
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Peripheral Nerve – High Power (H&E)Peripheral Nerve – High Power (H&E)
What’s the purple? What’s the white?
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Cross Section – Peripheral NerveCross Section – Peripheral Nerve
• What’s the purple?
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Peripheral NervePeripheral Nerve
• Why is this a Nerve, not a Ganglion?
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Key Points for PNSKey Points for PNS• Ganglia
– Contain cell bodies for motor ANS
– Satellite cells are the supporting cell bodies (not glial, Schwann, or others of CNS)
• Peripheral Nerves
– Schwann cells make mylin sheath
– Node of Ranvier / saltatory conduction / Na channels
– Endoneurium around neurons, which form fascicles
– Perineurium around fascicles, which form bundles
– Epineurium around bundles
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Same or different?Same or different?
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Same or different?Same or different?
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What are these?What are these?
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Questions 1 & 2. . .
A
B
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Question 3. . . Question 3. . .
Figure A Figure B
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Question 4. . . Question 4. . .
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Question 5. . . Question 5. . .
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Question 6. . . Question 6. . .
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