patients were required to have exercise-limiting angina with 2 1mm horizontal or downsloping ST depression on exercise treadmill testing. Exercise testing was performed during both peak (four hours after the intake of the drug) and trough (12 hours after the intake) of plasma ranolazine concentration and at the end of each treatment phase, in order to assess the clinical response and to establish a dose- response relationship. Chaitman et al. pointed out that ranolazine 500mg, lOOOmg and 1500mg twice daily significantly (P