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Herbal Assistance During the Winter Immune Season Dr. Wendy Warner, MD, ABIHM

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Herbal Assistance During the Winter Immune Season

Dr Wendy Warner MD ABIHM

Disclosure bull Scientific Advisory Board ndash Gaia Herbs

Planning Ahead bull Eating well now bull Getting the right amounttype of exercise bull Sleep how much how restful bull Shutting down the brain chatter bull Basic common sense hygiene etc bull Better gut health probiotics prebiotics

fermented foodsdrinks

Eating for Immune Boosting bull Increase Omega 3 fatty acids

ndash Reduces IL-1 and TNF alpha bull Decrease glycemic load

ndash Reduces IL-1 IL-6 and TNF alpha

Exercise bull Enough to lead to weight loss

ndash Reduces adipose tissue therefore lowers inflammation

bull Enough to lower cortisol ndash Can elevate both pro- and anti-inflammatory

cytokines

bull Beware overdoing exercise ndash Can put cortisol on overdrive which creates

inflammation increases adipose

Shutting Down the Brain Chatter bull Meditation has been shown to reduce IL-1 IL-

6 and TNF alpha

Shifting Emotions bull IgA levels affected for more than 6 hours by

only 5 minutes of strong emotion ndash 5 minutes of carelove improved IgA levels ndash 5 minutes of anger dropped IgA levels below

baseline for more than 6 hours

One Concept of Immune Function and its Organization

bull Surfacenonspecific Immune Response ndash Physical barrier breaks activates kinins

proinflammatory cytokines (IL-1 IL-6 TNF alpha IL-8) ndash Secretory system (phagocytes monocytes

neutrophils macrophages) bull InternalSpecific Immune Response

ndash Cell mediated (Th1 T helper T suppressor T cytotoxic lympokines) Cytokines produced

ndash Humoral (B cells Th2) antibodies produced bull Endocrine Immune Response bull Immune Reservoir

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Disclosure bull Scientific Advisory Board ndash Gaia Herbs

Planning Ahead bull Eating well now bull Getting the right amounttype of exercise bull Sleep how much how restful bull Shutting down the brain chatter bull Basic common sense hygiene etc bull Better gut health probiotics prebiotics

fermented foodsdrinks

Eating for Immune Boosting bull Increase Omega 3 fatty acids

ndash Reduces IL-1 and TNF alpha bull Decrease glycemic load

ndash Reduces IL-1 IL-6 and TNF alpha

Exercise bull Enough to lead to weight loss

ndash Reduces adipose tissue therefore lowers inflammation

bull Enough to lower cortisol ndash Can elevate both pro- and anti-inflammatory

cytokines

bull Beware overdoing exercise ndash Can put cortisol on overdrive which creates

inflammation increases adipose

Shutting Down the Brain Chatter bull Meditation has been shown to reduce IL-1 IL-

6 and TNF alpha

Shifting Emotions bull IgA levels affected for more than 6 hours by

only 5 minutes of strong emotion ndash 5 minutes of carelove improved IgA levels ndash 5 minutes of anger dropped IgA levels below

baseline for more than 6 hours

One Concept of Immune Function and its Organization

bull Surfacenonspecific Immune Response ndash Physical barrier breaks activates kinins

proinflammatory cytokines (IL-1 IL-6 TNF alpha IL-8) ndash Secretory system (phagocytes monocytes

neutrophils macrophages) bull InternalSpecific Immune Response

ndash Cell mediated (Th1 T helper T suppressor T cytotoxic lympokines) Cytokines produced

ndash Humoral (B cells Th2) antibodies produced bull Endocrine Immune Response bull Immune Reservoir

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Planning Ahead bull Eating well now bull Getting the right amounttype of exercise bull Sleep how much how restful bull Shutting down the brain chatter bull Basic common sense hygiene etc bull Better gut health probiotics prebiotics

fermented foodsdrinks

Eating for Immune Boosting bull Increase Omega 3 fatty acids

ndash Reduces IL-1 and TNF alpha bull Decrease glycemic load

ndash Reduces IL-1 IL-6 and TNF alpha

Exercise bull Enough to lead to weight loss

ndash Reduces adipose tissue therefore lowers inflammation

bull Enough to lower cortisol ndash Can elevate both pro- and anti-inflammatory

cytokines

bull Beware overdoing exercise ndash Can put cortisol on overdrive which creates

inflammation increases adipose

Shutting Down the Brain Chatter bull Meditation has been shown to reduce IL-1 IL-

6 and TNF alpha

Shifting Emotions bull IgA levels affected for more than 6 hours by

only 5 minutes of strong emotion ndash 5 minutes of carelove improved IgA levels ndash 5 minutes of anger dropped IgA levels below

baseline for more than 6 hours

One Concept of Immune Function and its Organization

bull Surfacenonspecific Immune Response ndash Physical barrier breaks activates kinins

proinflammatory cytokines (IL-1 IL-6 TNF alpha IL-8) ndash Secretory system (phagocytes monocytes

neutrophils macrophages) bull InternalSpecific Immune Response

ndash Cell mediated (Th1 T helper T suppressor T cytotoxic lympokines) Cytokines produced

ndash Humoral (B cells Th2) antibodies produced bull Endocrine Immune Response bull Immune Reservoir

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Eating for Immune Boosting bull Increase Omega 3 fatty acids

ndash Reduces IL-1 and TNF alpha bull Decrease glycemic load

ndash Reduces IL-1 IL-6 and TNF alpha

Exercise bull Enough to lead to weight loss

ndash Reduces adipose tissue therefore lowers inflammation

bull Enough to lower cortisol ndash Can elevate both pro- and anti-inflammatory

cytokines

bull Beware overdoing exercise ndash Can put cortisol on overdrive which creates

inflammation increases adipose

Shutting Down the Brain Chatter bull Meditation has been shown to reduce IL-1 IL-

6 and TNF alpha

Shifting Emotions bull IgA levels affected for more than 6 hours by

only 5 minutes of strong emotion ndash 5 minutes of carelove improved IgA levels ndash 5 minutes of anger dropped IgA levels below

baseline for more than 6 hours

One Concept of Immune Function and its Organization

bull Surfacenonspecific Immune Response ndash Physical barrier breaks activates kinins

proinflammatory cytokines (IL-1 IL-6 TNF alpha IL-8) ndash Secretory system (phagocytes monocytes

neutrophils macrophages) bull InternalSpecific Immune Response

ndash Cell mediated (Th1 T helper T suppressor T cytotoxic lympokines) Cytokines produced

ndash Humoral (B cells Th2) antibodies produced bull Endocrine Immune Response bull Immune Reservoir

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Exercise bull Enough to lead to weight loss

ndash Reduces adipose tissue therefore lowers inflammation

bull Enough to lower cortisol ndash Can elevate both pro- and anti-inflammatory

cytokines

bull Beware overdoing exercise ndash Can put cortisol on overdrive which creates

inflammation increases adipose

Shutting Down the Brain Chatter bull Meditation has been shown to reduce IL-1 IL-

6 and TNF alpha

Shifting Emotions bull IgA levels affected for more than 6 hours by

only 5 minutes of strong emotion ndash 5 minutes of carelove improved IgA levels ndash 5 minutes of anger dropped IgA levels below

baseline for more than 6 hours

One Concept of Immune Function and its Organization

bull Surfacenonspecific Immune Response ndash Physical barrier breaks activates kinins

proinflammatory cytokines (IL-1 IL-6 TNF alpha IL-8) ndash Secretory system (phagocytes monocytes

neutrophils macrophages) bull InternalSpecific Immune Response

ndash Cell mediated (Th1 T helper T suppressor T cytotoxic lympokines) Cytokines produced

ndash Humoral (B cells Th2) antibodies produced bull Endocrine Immune Response bull Immune Reservoir

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Shutting Down the Brain Chatter bull Meditation has been shown to reduce IL-1 IL-

6 and TNF alpha

Shifting Emotions bull IgA levels affected for more than 6 hours by

only 5 minutes of strong emotion ndash 5 minutes of carelove improved IgA levels ndash 5 minutes of anger dropped IgA levels below

baseline for more than 6 hours

One Concept of Immune Function and its Organization

bull Surfacenonspecific Immune Response ndash Physical barrier breaks activates kinins

proinflammatory cytokines (IL-1 IL-6 TNF alpha IL-8) ndash Secretory system (phagocytes monocytes

neutrophils macrophages) bull InternalSpecific Immune Response

ndash Cell mediated (Th1 T helper T suppressor T cytotoxic lympokines) Cytokines produced

ndash Humoral (B cells Th2) antibodies produced bull Endocrine Immune Response bull Immune Reservoir

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Shifting Emotions bull IgA levels affected for more than 6 hours by

only 5 minutes of strong emotion ndash 5 minutes of carelove improved IgA levels ndash 5 minutes of anger dropped IgA levels below

baseline for more than 6 hours

One Concept of Immune Function and its Organization

bull Surfacenonspecific Immune Response ndash Physical barrier breaks activates kinins

proinflammatory cytokines (IL-1 IL-6 TNF alpha IL-8) ndash Secretory system (phagocytes monocytes

neutrophils macrophages) bull InternalSpecific Immune Response

ndash Cell mediated (Th1 T helper T suppressor T cytotoxic lympokines) Cytokines produced

ndash Humoral (B cells Th2) antibodies produced bull Endocrine Immune Response bull Immune Reservoir

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

One Concept of Immune Function and its Organization

bull Surfacenonspecific Immune Response ndash Physical barrier breaks activates kinins

proinflammatory cytokines (IL-1 IL-6 TNF alpha IL-8) ndash Secretory system (phagocytes monocytes

neutrophils macrophages) bull InternalSpecific Immune Response

ndash Cell mediated (Th1 T helper T suppressor T cytotoxic lympokines) Cytokines produced

ndash Humoral (B cells Th2) antibodies produced bull Endocrine Immune Response bull Immune Reservoir

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Surface Nonspecific bull Echinacea bull Yarrow bull Demulcents

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Internal Specific bull Cell mediated

ndash Ganoderma (Reishi ) ndash Lonicera (Honeysuckle) ndash Garlic

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Internal Specific bull Humoral

ndash Stimulate activity bull Echinacea bull Elderberry

ndash Reduce excess activity bull Scutellaria bull Turmeric bull Bupleurum bull Immune amphoterics

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Endocrine Immune Response bull HPA axis has direct effect on immune system

ndash Adaptogens ndash Nervines

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Immune Reservoir bull Doesnrsquot exist per se bull Overall ability to mount immune response bull Immune potentiators

ndash Ganoderma ndash Grifola ndash Astragalus ndash Chaga

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Others bull Immune Amphoterics

ndash Normalize immune response

bull Alteratives ndash Increase resistance by improving eliminatory

function and circulation

bull Lymphatic Tonics ndash Improve lymphatic circulation and drainage

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Echinacea bull Nonspecific and humoral

immunity bull Use early in acute infection bull Not for daily use bull Best for respiratory illnesses to

reduce duration and severity of symptoms

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Mechanism of Action Echinacea bull Stimulates production of IL-6 TNF IL-12 and

NO from macrophages in vitro bull Initiates a signaling cascade within

macrophages through both TLR4-dependent and -independent mechanisms involving ERK p38 and JNK and ultimately the activation of NF-kappaB

bull Sullivan AM1 Laba JG Moore JA Lee TDImmunopharmacol Immunotoxicol 200830(3)553-74

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Dosing Echinacea bull Tincturemdash(1225) 40-60 drops every 2-3

hours bull Dry herb and root 2-3 gram daily bull Liquid Extract of root 12 3-10 mls daily bull Echinacea purpurea juice of fresh plant 6-9mls

daily

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Honeysuckle (Lonicera japonica) bull Internal specific immunity bull In TCM clears blood heat (infections)

including high fevers from strep throat pneumonia sinusitis bronchitis

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Mechanism of Action Honeysuckle bull In combination with forsythia appears to

activate host defense system as well as directly inhibit virus proliferation

ndash Integr Biol (Camb) 2013 Feb 5(2)351-71

bull Might increase neutrophil activity and increase phagocytosis

ndash Natural medicines database

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Dosing Honeysuckle bull Tincturemdash(14) 30-40 drops qid

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Forsythia (Forsythia suspensa) bull Antibacterial bull Antiviral bull Anti-inflammatory bull Antioxidant bull Immunoregulatory bull In Chinese medicine removes toxic heat

(infections) in the blood and respiratory systems

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Mechanism of Action Forsythia bull In Influenza colds viral pneumonia

bronchitis sinusitismdashappears to be antiviral bull Used in China with licorice houttuynia and

honeysuckle to treat SARS

bull J Ethnopharmacol 2006 Sep 19107(2)205-10 bull J Med Plants Res 20104(14)1455-8

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Dosing Forsythia bull Tincturemdash(14 or 15) 15-30 drops tid bull Tea (decoction)mdash12 dried seedpods 8

ounces water decoct 10 min then steep 15-20 min Up to 2 cups daily

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Andrographis (Andrographis paniculata)

bull Internalhumoral stimulatory action bull Antiviral bull Antibacterial bull Good for influenza

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Mechanism of Action Andrographis

bull Anti-inflammatory bull Immunostimulant bull Antipyretic

bull E Ernst Planta Med 2004 70 294-298

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Dosing Andrographis bull Tincturemdash(14) 20-40 drops qid bull Adult 2-3 grams daily 4-6mls 12 extract bull Acute infection use 6 grams daily or up to 12mls

daily bull Combine with warming herbs such as ginger

cinnamon and astragalus bull Children 5-1 gram daily 5 ndash 2 mls extract bull Acute infection use 2 grams daily and 4 mls 12

extract

bull Warning very bitter

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Black Elderberry (Sambucus nigra) bull Antiviral bull Increases inflammatory and anti-inflammatory

cytokines bull Significant studies show faster recovery from

influenza bull Syrups most common

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Mechanism of Action Elderberry bull Blocks viral attachment to host cell bull Increases inflammatory cytokines

ndash IL-1 IL-6 IL-8 TNF alpha

bull Increases anti-inflammatory cytokines ndash IL-10

bull Eur Cytokine Netw 2001 Apr-June12(2) 290-6

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Dosing Elderberry bull Tincture (1115) 60-90 qid bull Also historically used in syrups jams cordials and

wines bull Elderberry fruit syrups- standardized to 30-38

percent elderberry bull Powdered extracts- 500 mg (capsule) 2-3 times

daily for 3-4 days bull Liquid form dosed at one tablespoonful (15 mL)

three times daily bull Acute viral infections- treat at least three days

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Turmeric (Curcuma longa) bull Many many modes of action bull Internalhumoral activity bull Decreases excess humoral activity bull Anti-inflammatory antioxidant antibacterial

antitumor

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Mechanisms of Action Turmeric bull Inhibits neutrophil function bull Inhibits lymphocyte activity bull Inhibits NF-kB bull (and others)

bull Mol Nutr Food Res 2013 57 1529-42 bull Adv Pharmacol Sci 7pp

dxdoiorg1011552013805756

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Dosing Turmeric bull Tincturemdash(12) 40-60 drops qid bull General use 15 - 75 mg of Curcumin daily in 3-4

divided doses bull As a tea 1-15g of dried root may be steeped in

150 mL of water for 15 minutes taken 2-3x daily bull Antioxidant two 500 mg oral doses daily use for

three months

bull Absorption enhanced by addition of black pepper

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Reishi (Ganoderma lucidum) bull Adaptogenic bull Immune potentiator bull Anti-inflammatory bull Antioxidant bull ldquoImmune amphotericrdquo bull Good for allergies

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Mechanism of Action Reishi bull Stabilizes mast cells reduces histamine

response bull Improves innate regulatory capacity bull Stimulates TNF alpha IL-1 IL-6 Th1 T

lymphocytes bull Nervine

bull Nutr Cancer 200553(1)11-7

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Dosing Reishi bull Tincturemdash(15) 80-100 drops 4-6x daily bull Decoctionmdash1-2 oz dried mushroom to 32 oz

water Decoct 2-4 hrs Up to 4 cups daily bull 30mlsday15 liquid extract bull 6-12 g dry powder bull 5-1gday concentrated extract

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Astragalus (Astragalus membranaceus) bull Immune potentiator

immune amphoteric bull Immunosuppressive for

cancer bull Used for immune excess as

well (allergies) bull In Chinese medicine

enhances the wei qi which suppresses sweating and helps fight external infections of the lungs

bull Prevents but doesnrsquot really treat acute viralbacterial infections

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Mechanism of Action Astragalus bull Potentiates IL-2 and monocyte activity bull Enhance NK cell activity bull Modulates TNF alpha

bull Clin Nephrol 1999 Nov52(5)333-4 bull J Clin Lab Immunol 198826183-7 bull American Herbal Pharmacopoeia 199911-25

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Dosing Astragalus bull Tincture-- (15) 40-80 drops tid bull Decoction-- 2 tbl dried root to 12 oz water Up

to 3 cups per day bull 10-30 grams dry root bull 5-10 mls day of 13 liquid extract bull Or cook with it (soup)

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Adaptogens and Nervines bull Ashwaganda bull Holy Basil bull Rhodiola bull Ginsengs bull Lemon Balm bull Milky Oats

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Immune Potentiators bull Reishi bull Maitake bull Licorice bull Eleutherococcus bull Cordyceps

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Alteratives bull Hoxsey (as published in 1956)

ndash Barberry buckthorn bark burdock root cascara sagrada licorice root poke root prickly ash red clover blossoms and stillingia root in a water base with potassium iodide

bull Scudders ndash Corydalis alder bark mayapple fig wort yellow

dock

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Lymphatic Tonics bull Red clover bull Cleavers bull Poke bull Burdock bull Fig wort bull Violet

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Getting These Herbs to Patients bull Consider dispensing these herbs in clinic versus

referring patients to retail Why ndash Consumers have no good mechanism to validate

quality of brandsproducts you are the filter ndash Once you send patients to ldquofend for themselvesrdquo you

do not know if they ever bought the product or worse if they bought a lower quality product

bull Alternative approach is to utilize a patient direct shipping option

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

All Botanicals are Not Created Equal bull 5 Pillars of Quality Botanicals ndash varies by

manufacturer ndash Design Evidence-based formulation amp appropriate dosage

form ndash Authenticity Ingredient identity is always verified using

validated methods ndash Potency Ingredient amp finished product potency is verified

using validated methods ndash Purity Proven freedom from biological amp chemical

contaminants ndash Validation Evidence of safety and efficacy for intended

use

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Questions to Ask Manufacturers 1 Do you buy your herbal raw materials directly from the grower

or from an intermediary supplier 2 Do you grow any of your own botanicals 3 How do you validate herbal raw material genus and species 4 Are your herbal ingredients organic Are they ecologically wild

harvested 5 What solvents do you use to extract your herbs 6 Are you Prop 65 compliant 7 Can you provide test results for your products showing results

of heavy metal tests testing for pesticides and other contaminants

8 How do you validate potency Can you provide results of potency testing

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Botanical Medicine Resources bull Links for study and institutions

ndash American Botanical Council httpabcherbalgramorg ndash American Herbal Products Association

httpwwwahpaorg ndash Natural Medicines (formerly Natural Standard)

httpsnaturalmedicinestherapeuticresearchcom ndash Henriettersquos Herbal Homepage

httpwwwhenriettesherbalcom ndash Herb Research Foundation

httpwwwherbsorgherbnews ndash Dr Dukes Database (Phytochemical Database)

httpwwwars-gringovduke ndash Gaia Herbs Professional Solutions

wwwgaiaprofessionalcom

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Botanical Medicine Resources bull Herb books

ndash Principles and Practice of Phytotherapy- Modern Herbal

Medicine Simon Mills and Kerry Bone ndash Healing with Whole Foods- Oriental Traditions and Modern

Tradition Paul Pitchford ndash Medical Herbalism and The New Holisitc Herbal David Hoffman ndash Womenrsquos Encyclopedia of Natural Medicine Dr Tori Hudson ndash Encyclopedia of Natural Healing for Children and Infants Dr

Mary Bove ndash Adaptogens in Medical Herbalism Donald Yance ndash Botanical Medicines for Womenrsquos Health Dr Aviva Romm ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona

Low Dog

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Botanical Medicine Resources bull Herb books (continued)

ndash National Geographicrsquos Guide to Medicinal Herbs Dr Tieraona Low Dog

ndash Integrative Womenrsquos Health Low Dog and Maizes ndash Botanical Safety Handbook AHPA ndash Textbook of Natural Medicine Pizzorno and

Murray ndash Herbal Medicines in Pregnancy and Lactation

Mills Dugoua Perri Koren

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Botanical Medicine Resources bull Publications

ndash Herbal Gram ndash American Botanical Council ndash Townsend Letter ndash Integrative Medicine A Clinicianrsquos Journal ndash Journal of Alternative and Complementary

Medicine

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You

Thank You

  • Herbal Assistance During the Winter Immune Season
  • Disclosure
  • Planning Ahead
  • Eating for Immune Boosting
  • Exercise
  • Shutting Down the Brain Chatter
  • Shifting Emotions
  • One Concept of Immune Function and its Organization
  • Surface Nonspecific
  • Internal Specific
  • Internal Specific
  • Endocrine Immune Response
  • Immune Reservoir
  • Others
  • Echinacea
  • Mechanism of Action Echinacea
  • Dosing Echinacea
  • Honeysuckle (Lonicera japonica)
  • Mechanism of Action Honeysuckle
  • Dosing Honeysuckle
  • Forsythia (Forsythia suspensa)
  • Mechanism of Action Forsythia
  • Dosing Forsythia
  • Andrographis (Andrographis paniculata)
  • Mechanism of Action Andrographis
  • Dosing Andrographis
  • Black Elderberry (Sambucus nigra)
  • Mechanism of Action Elderberry
  • Dosing Elderberry
  • Turmeric (Curcuma longa)
  • Mechanisms of Action Turmeric
  • Dosing Turmeric
  • Reishi (Ganoderma lucidum)
  • Mechanism of Action Reishi
  • Dosing Reishi
  • Astragalus (Astragalus membranaceus)
  • Mechanism of Action Astragalus
  • Dosing Astragalus
  • Adaptogens and Nervines
  • Immune Potentiators
  • Alteratives
  • Lymphatic Tonics
  • Getting These Herbs to Patients
  • All Botanicals are Not Created Equal
  • Questions to Ask Manufacturers
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Botanical Medicine Resources
  • Thank You