Herbs, Foods and Nutrients

for Healthy Microcirculation

Kerry BoneAdjunct ProfessorNew York Chiropractic College

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Integria Healthcare Ltd and Standard Process®

sponsor these webinars to provide health care information to practitioners and to provide them the opportunity to hear about the views, recommendations and experiences of other practitioners. Health-related information provided here is not a substitute of medical advice.

Integria, Standard Process and the speaker, Kerry Bone, have not evaluated the legal status of any products (except for Standard Process and MediHerb® products), services or recommendations with respect to state or federal laws, including scope of practice. Integria, Standard Process and Kerry Bone do not and cannot accept responsibility for errors or omissions or for any consequences from applications of the information provided and makes no warranty, expressed or implied, with respect to the information provided.

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Gotu Kola andMicrocirculation

Two controlled trials have investigated the activity of Gotu Kola actives (triterpenoids)

The largest trial involved 100 patients and compared the extract with placebo over 12 months and also 40 healthy controls1

It was significantly more effective at improving microcirculatory measures and edema

1 Incandela L, Belcaro G, Cesarone MR et al. Angiology 2001; 52(Suppl 2): S27-S31

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Gotu Kola andMicrocirculation

A smaller trial in 50 patients compared Gotu Kola actives to placebo or no treatment for 6 months

There were significant improvements in measures linked to the microcirculatory system, including capillary permeability

Cesarone MR, Incandela L, De Sanctis MT et al. Angiology 2001; 52(Suppl 1-2): S49-S54 4

Funaki 2008

Ginkgo and Microcirculation

A single dose of standardized Ginkgo extract(112.5 mg) resulted in a significant increase in blood flow in nail capillaries in healthy volunteers1

Another study demonstrated increased blood flow to the forearms of volunteers2

This confirms the ability of Ginkgo to enhance microcirculatory flow

1 Jung F et al. Arzneimittelforschung 1990; 40(5): 589-5932 Mehlsen J et al. Clin Physiol Funct Imaging 2002; 22(6): 375-378

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Grape Seed andMicrocirculation

Numerous clinical trials using doses of between 100 and 150 mg/day of OPCs from Grape Seed have demonstrated a beneficial effect on capillary resistance and capillary permeability

For example, 100 mg/day of OPCs was administered to elderly patients with capillary fragility

Very good results were achieved in 67%, good in 17% and moderate in 13%

Morgan M, Andrews C. Nutritional Perspective 2007; 26: 1-3

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Garlic and Microcirculation

Garlic (particularly as the fresh-crushed raw clove or as an allicin-releasing powder) is good for both the microcirculation and microcirculatory flow1

For example, in a controlled clinical trial a single 900 mg dose of Garlic powder significantly increased capillary skin perfusion by 55%

1 Jung EM, Jung F, Mrowietz C et al. Arzneimittelforschung 1991; 41(6): 626-630

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Garlic and Microcirculation

Another study found that Garlic powder (600 mg/day) administered for 7 days increased calf blood flow by approximately 15%

Anim-Nyame N, Sooranna SR, Johnson MR et al. Garlic supplementation increases peripheral blood flow: a role for interleukin-6? J Nutr Biochem 2004; 15(1): 30-36

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Rudiga Wolk 2006

Bilberry and Microcirculation

In open trials, bilberry extract improved symptoms caused by decreased capillary resistance (fragility, bleeding and bruising)1

1 Piovella C, Curri BS, Piovella M et al. Therapia Angiol 1979; 35: 1199

Pleple2000 2008

Beets and Microcirculation

Beets Nitrate It is now realized that a specific pathway in the

body can make nitric oxide from dietary nitrate; the nitrate-nitrite-nitric oxide pathway

This has profound implications for microcirculatory and endothelial health, and for healthycirculatory function

Morgan M. Beet, Greens & Herbs for Health & Vitality. Nutritional Perspective2013; 38: 1-7

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BriannaWalther 2009

Cocoa is Healthy!

There are several studies suggestive of cocoa’s positive effect on the microcirculation and endothelium

In a clinical trial, the impairment of endothelial function caused by a glucose challenge was reduced by dark chocolate, but not white chocolate1

Dark chocolate supported healthy endothelial function in breath-hold divers2

1 Grassi D, Desideri G, Necozione S et al. Hypertension 2012; 60(3): 827-8322 Theunissen S, Schumacker J, Guerrero F et al. Eur J Appl Physiol 2013;

113(12): 2967-2975

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Green Tea andEndothelial Health

Green Tea (2 weeks) supported healthy forearm endothelial function in smokers1

There was a significant increase in plasma nitric oxide

Green Tea (4 weeks) improved flow mediated dilatation (from 5.7 ± 2.7% to 8.7 ± 3.5%) in patients with chronic kidney disease2

1 Oyama J, Maeda T, Kouzuma K et al. Circ J 2010; 74(3): 578-5882 Park CS, Kim W, Woo JS et al.. Int J Cardiol 2010; 145(2):261-262

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The 5-Point Dietary Plan

1. Boost dietary nitrate: green leafy vegetables, but especially beets as juice or a supplement

2. Increase cocoa intake: 85% chocolate, about 2/3 oz/day

3. Increase berry anthocyanin intake: 2 to 3 oz/day of blueberries, strawberries, raspberries and blackberries

4. Raw crushed Garlic: ½ to 1 clove/day5. Increase herbs and spices: especially Green Tea

(3 to 4 cups/day), Turmeric and Ginger

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Gymnema

Known in Hindi as gurmar or sugar destroyer When applied to the mouth it anesthetises the

sweet taste buds for several hours Been used to address healthy blood sugar

metabolism for more than 2000 years Activity has been verified by clinical trials

Bone, K. 2003, A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient, Churchill Livingstone, St. Louis, pp. 267-269.

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Lowering GI with Herbs

The glycemic index (GI) is an assessment of the rate of glucose elevation in the bloodstream following the intake of a particular food

Any herb which delays gastric emptying will reduce GI. These include mucilages.

Tannins (eg Green Tea) also interfere with digestive processes and saponins (eg Gymnema) can disrupt glucose transport

Milk Thistle and Healthy Sugar Metabolism

A recent placebo-controlled clinical trial found that Silymarin extract (200 mg TDS) for 4 months exerted a beneficial effect on glycemic profile in relatively well-controlled people

There were significant reductions in HbA1C(13%), fasting blood glucose (15%), total cholesterol (12%), LDL-cholesterol (11%) and triglycerides(25%)

Huseini H, Larijani B, Heshmat R et al. Phytother Res 2006; 20(12): 1036-1039

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Korean Ginseng andHealthy Sugar Metabolism

In well-controlled people Korean Ginseng caused no change in HbA1C or fasting plasma glucose in a placebo-controlled clinical trial

However, fasting plasma insulin was significantly reduced for Korean Ginseng (by 34%) whereas it increased in the placebo group (by 10%)

In other words Korean Ginseng lowered insulin resistance

Vuksan V, Sung MK, Sievenpiper JL, et al. Nutr Metab Cardiovasc Dis 2008; 18(1): 46-56

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Resveratrol and Healthy Sugar Metabolism

Resveratrol has improved healthy insulin response in clinical trials

In one trial just 10 mg per day over 4 weeks (randomized, placebo-controlled) improved insulin responses and incretin levels

Brasnyó P, Molnár GA, Mohás M et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011; 106(3): 383-389

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Discussion and Questions

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