healthtech heartbeat - 2014 market review

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Healthcare IT - Europe Healthcare IT - US Biopharma IT Generalists NASDAQ Composite Index FTSE 100

Results International Global HeathTech Indices

Note: Based on share prices as at 31 December 2014

Note: Indices weighted by market capitalisation

Note: Biopharma IT index predominantly reflects Veeva performance since IPO in October 2013

Note: (1)

Excludes Generalists

Sources: Capital IQ and Results analysis

3

15.8%

11.4%

13.4%

7.0%

-19.2%

-2.7%

Q4 2014 Performance

Healthcare IT – Europe 7.8%

Healthcare IT - US 6.0%

Biopharma IT -0.6%

Generalists 8.4%

HealthTech(1)

5.7%

4.7%

20.1% 17.0% 17.0%

6.8%

-7.6%

34.1%

6.6% 8.5%

31.1%

-2.1%

10.6%

-4.8% -4.6% -9.6%

13.2%

22.8%

5.7%

61.8%

-6.2%

7.8%

-5.4%

-20.0%

-10.0%

0.0%

10.0%

20.0%

30.0%

40.0%

50.0%

60.0%

70.0%

Q4-2

014

7.4%

33.1% 33.8% 27.5% 28.6%

-9.3%

58.7%

28.6%

16.0%

49.0%

11.5% 8.3%

-17.4%

-0.4%

-70.6%

-26.0%

-9.6% -1.7%

53.4%

-17.7% -21.1% -15.9%

-80.0%

-60.0%

-40.0%

-20.0%

0.0%

20.0%

40.0%

60.0%

80.0%

Last

12 M

on

ths

HealthTech: Share Price Performance

Note: Share price performance as at 31 December 2014

Note: *‘Last 12 Months’ reference dates adjusted to first trading day post IPO for IMS Health Holdings (03-Apr-14) and Castlight (13-Mar-14)

Note: Allocate Software and Carefusion Corporation subject to takeover by Hg Capital (announced 14-Oct-14) and Becton Dickinson (5-Oct-14) respectively

Sources: Capital IQ and Results analysis 4

* *

Healthcare IT – Europe Healthcare IT – US Biopharma IT

Company IPO

Date Description Raised

Indicative

Price Range

($)

IPO Price

($)

Increase vs.

range

Day 1

Increase

Current

Increase(1)

Current

EV

EV / Revenue

2014E

EV / EBITDA

2014E

Apr-14

Healthcare information technology and services

1,300.0 18.00-21.00 20.00 2.5% 15.0% 28.2% 12,334 4.7x 14.1x

Mar-14 Healthcare enterprise management software

177.6 13.00-15.00 16.00 14.3% 148.8% -26.9% 874 19.8x n.m.(2)

Dec-13

Software, hardware and services for the healthcare and energy sectors

199.7 n.a. 2.93 n.a. 20.1% 58.0% 297 3.5x 15.5x

Oct-13

Cloud-based CRM software for the biopharma industry

260.9 16.00-18.00 20.00 17.6% 86% 32.0% 3,036 10.0x 36.3x

HealthTech: Recent IPO Performances

5

NYSE

NYSE

LSE

NYSE

Note: Calendarised to December year end; $ millions, except share price data

Note: (1)

Current increase from IPO price; Market data as of 31 December 2014

Note: (2)

Castlight projecting negative EBITDA for CY2014

Source: Capital IQ

HealthTech: Valuation Benchmarks

6

EBITDA Margin 2014E EV / EBITDA 2014E

Revenue Growth (2014-15E) EV / Revenue 2014E

Note: EV = Enterprise Value; Financials calendarised to December year end

Note: Median values reported; exclude negative multiples

Note: See Selected Publicly Traded Companies (Slide 12) for details of companies included in each category

Note: McKesson excluded from above analysis because majority of revenue is generated from pharmaceutical distribution

Source: Capital IQ

3.8%

6.7% 5.9%

21.4%

0.0%

5.0%

10.0%

15.0%

20.0%

25.0%

Generalists Healthcare IT -

Europe

Healthcare IT -

US

Biopharma IT

30.4%

22.3% 22.1% 22.3%

0.0%

5.0%

10.0%

15.0%

20.0%

25.0%

30.0%

35.0%

Generalists Healthcare IT -

Europe

Healthcare IT -

US

Biopharma IT

3.9 x 3.5 x

3.2 x

7.9 x

0.0 x

1.0 x

2.0 x

3.0 x

4.0 x

5.0 x

6.0 x

7.0 x

8.0 x

9.0 x

Generalists Healthcare IT -

Europe

Healthcare IT -

US

Biopharma IT

12.0 x 13.1 x 13.8 x

35.4 x

0.0 x

5.0 x

10.0 x

15.0 x

20.0 x

25.0 x

30.0 x

35.0 x

40.0 x

Generalists Healthcare IT -

Europe

Healthcare IT -

US

Biopharma IT

16 19

21

17 20

32 29

18

28 27 28

32

44

61

3

4

3

5

1 1

7

2 7 5

6

2

8

0

2,000

4,000

6,000

8,000

10,000

12,000

14,000

16,000

18,000

0

10

20

30

40

50

60

70

80

Q3 2011 Q4 2011 Q1 2012 Q2 2012 Q3 2012 Q4 2012 Q1 2013 Q2 2013 Q3 2013 Q4 2013 Q1 2014 Q2 2014 Q3 2014 Q4 2014

Healthcare IT Biopharma IT Healthcare IT Total Disclosed Deal Value Biopharma IT Total Disclosed Deal Value

HealthTech: Global M&A Activity N

um

be

r o

f D

ea

ls

Sources: Press releases, Capital IQ, Mergermarket, 451 Research and Results analysis 7

Tota

l D

isc

lose

d D

ea

l V

alu

e (

$m

)

HealthTech: Selected Deals in 2014

Date Buyer Target EV ($m) EV /

Revenue

EV /

EBITDA Description

Target

location

Dec-14 10.1 1.0x n.a. Diabetic eye screening and ophthalmology imaging services

Dec-14 n.a. n.a. n.a. Software and services for UK public sector markets including government

agencies, public safety, housing and healthcare

Dec-14 25.4 2.0x 10.1x Risk and compliance management software for healthcare, manufacturing

and aviation

Dec-14 19.7 1.1x 2.8x Image processing software for cancer screening

Dec-14 36.9 2.5x 11.3x Social care case management software

Nov-14 1,230.8 3.7x 16.2x Software provider to private and public sectors including healthcare

Nov-14 52.2 4.1x n.a. Embryo analysis equipment and software for IVF

Nov-14 150 n.a. n.a. Tissue image analysis software

Oct-14 11.7 2.2x 7.8x Orthopaedic procedure planning software

Oct-14 152.1 2.3x 14.2x Workforce management, governance and risk compliance software for

primary, secondary and social care

Oct-14 n.a. n.a. n.a. Digital marketing services and business management software for the life

sciences industry

Oct-14 11,803.0 3.1x 14.7x Medical hardware and software technology

Sep-14 n.a. n.a. n.a. Practice management and analytics software for secondary care

Sep-14 n.a. n.a. n.a. Dispensary management software for pharmacies

Sep-14 2,700.0 3.8x n.a. Healthcare IT solutions for payers and care providers

Sep-14 n.a. n.a. n.a. Pharmacy management software

Aug-14 2.1 n.a. n.a. Mobile technology and patient connectivity

8

Note: Financials relate to the companies’ full fiscal year before the transaction took place

Note: Enterprise Value (EV) = transaction value scaled to 100% shareholding plus net debt (includes minority interest)

Sources: Press releases, Capital IQ, Mergermarket, 451 Research and Results analysis

Note: Financials relate to the companies’ full fiscal year before the transaction took place

Note: Enterprise Value (EV) = transaction value scaled to 100% shareholding plus net debt (includes minority interest)

Sources: Press releases, Capital IQ, Mergermarket, 451 Research and Results analysis

HealthTech: Selected Deals in 2014

Date Buyer Target EV ($m) EV /

Revenue

EV /

EBITDA Description

Target

location

Aug-14

Health Services Assets

1,300.0 n.a. n.a. Healthcare IT for primary and secondary care

Jul-14 n.a. n.a. n.a. Health economics optimisation software

Jul-14 5.5 1.3x 4.6x Data display, integration and messaging solutions for the NHS and private care

providers

Jul-14 71.8 2.8x 9.3x Trial Master File solutions provider

Jul-14 n.a. n.a. n.a. Patient Administration Systems & Electronic Patient Records

Jun-14 Information & CRM Solutions Assets

523.5 0.9x 6.0x Information & CRM solutions for the life sciences industry

Jun-14 n.a. n.a. n.a. Electronic Patient Records for health and social care

May-14 n.a. n.a. n.a. Data analytics solutions for decision-making support

Apr-14 0.2 0.5x n.a. Medical imaging software

Apr-14 550.0 n.a. n.a. Web-based workflow solutions for clinical and administrative tasks

Mar-14 15.4 2.3x n.a. Online compliance training & tracking solutions for secondary care and nursing

facilities

Feb-14 n.a. n.a. n.a. Supply chain management software for healthcare providers, manufacturers

and distributors

Feb-14 n.a. n.a. n.a. Maternity, radiology and primary care information systems

Jan-14 630 3.7x n/m Enterprise management software for drug discovery

Jan-14 n.a. n.a. n.a. Primary care clinical information systems

Jan-14 n.a. n.a. n.a. Software solutions for laboratories and diagnostics

Jan-14 n.a. n.a. n.a. Sales & marketing software for the pharmaceutical industry

9

Date Company Type of

round

Funds

raised ($m) Investor participation Description

Company

headquarters

Dec-14 Series B 8.7 - Point of care hospital information system

Dec-14 - 5.0 Maggioli S.p.A., Tamburi Investment Partners, Ghenos Srl Electronic Medical Record and diagnostic solutions for

primary and secondary healthcare

Dec-14 Series B - Private investor Mobile patient data access platform

Dec-14 Venture 5.0 Scottish Equity Partners, Albion Ventures Patient engagement and data capture software

Nov-14 Venture 16.3 Top Technology Ventures, Invesco Perpetual, IP Group,

Lansdowne Partners, Woodford Investment Management Genomic sequence data analysis software

Nov-14 Venture 1.7 Maxfield Capital Management Fund Patient treatment management telemedicine application

Nov-14 Venture 5.6 Sofinnova Partners, Balderton Capital Online platform for accessing drugs under development

Oct-14 Angel 0.8 Enterprise Ireland Appointment scheduling and CRM software for therapists

and healthcare clinics

Oct-14 Venture 2.5 Participatiemaatschappij Vlaanderen, QBIC Venture

Partners, Fournier-Majoie Foundation Genomic sequence data analysis software

Oct-14 Venture 1.6 Crown Ocean Capital Patient exercise management telemedicine application

Sep-14 Series A 2.0 Isis Innovation, Parkwalk Advisors, Chimera Partners Stroke damage evaluation software for CT scans

Sep-14 Seed 2.6 - Drug development software and consultancy

Sep-14 Venture 0.3 - Mental health tracking telemedicine application

Sep-14 Seed 0.4 Mercia Fund Management Diagnostic and clinical trials software for optometry

Aug-14 Seed 0.1 Bayer AG Cardiac monitoring mobile telemedicine application

Aug-14 Series C 0.6 Amadeus Capital Partners Primary care practice and case management software

Aug-14 Angel 1.2 - Clinical decision support software

HealthTech: Selected European Fundraisings in 2014

10 Sources: VentureSource and Capital IQ

Date Company Type of

round

Funds

raised ($m) Investor participation Description

Company

headquarters

Aug-14 Seed 0.3 Rheingau Founders Web-hosted medical consultation platform

Jul-14 Series B 13.8 Endeavour Vision, Swisscom, Asset Management Arm,

Invoke Capital Data-driven diagnostic testing platform

Jun-14 BREAKBAD Seed 0.3 London Business Angels Addiction management mobile application

Jun-14 Seed - ACT Venture Capital Clinical data capture / analysis and revenue cycle

management

May-14 Seed 0.8 Enterprise Ireland Appointment scheduling and CRM software for therapists

and healthcare clinics

May-14 Venture 5.8 Capricorn Venture Partners, Gemma Frisius Fonds,

Participatiemaatschappij Vlaanderen Genetic information analysis and reporting software

May-14 Venture 3.4 Top Technology Ventures, IP Group, ORA Capital Partners Video software for the measurement of vital signs

May-14 Angel 0.4 Midven Various mobile healthcare applications

May-14 Venture - Peppermint VenturePartners, Stiftung Charité Visual therapy platform

Apr-14 Series D 28.7 QUALCOMM Ventures, Bpifrance Investissement, Cap

Décisif Management, and others

Medication adherence and symptom management

application

Apr-14 Series A 3.8 Index Ventures, Forward Partners Behavioural medicine delivery software

Mar-14 Series A 6.9 ACG Management, EXTENS Interoperabiltiy and security software

Mar-14 Seed 1.0 Technology Strategy Board Knowledge sharing and education platform

Mar-14 Series A 0.7 Intel, Vodafone Mobile patient data access platform

Feb-14 Venture 2.2 - Online platform for accessing drugs under development

Jan-14 Seed - SEED Capital Denmark Stroke treatment support software

Jan-14 Seed 0.1 Wayra Investigación y Desarrollo Genetic matching ePrescription software

HealthTech: Selected European Fundraisings in 2014

11 Sources: VentureSource and Capital IQ

Operating Metrics Valuation Metrics

Price % of 52 Market Total Net Enterprise Revenue Rev. Growth Gross Margin Revenue EBITDA

Company (31-Dec-14) Week High Cap Cash Debt Value CY2014 CY14-15 Historical CY2014 CY2015 CY2014 CY2015 CY2014 CY2015

Generalists with significant HealthTech exposure

Oracle Corporation 44.97 96% 207,407 51,616 (18,469) 188,938 38,920 3.5% 61.3% 47.8% 50.3% 4.9 x 4.7 x 10.2 x 9.3 x

SAP SE 70.62 93% 86,125 3,390 1,253 87,378 21,166 7.9% 72.6% 34.4% 34.9% 4.1 x 3.8 x 12.0 x 11.0 x

EMC Corporation 29.74 96% 61,383 8,147 (1,031) 60,352 24,501 7.4% 62.3% 30.4% 30.6% 2.5 x 2.3 x 8.1 x 7.5 x

Thermo Fisher Scientific, Inc. 125.29 97% 50,930 544 13,939 64,869 16,789 3.8% 42.5% 23.9% 25.4% 3.9 x 3.7 x 16.1 x 14.7 x

Thomson Reuters Corporation 40.47 98% 32,779 1,788 7,694 40,473 10,937 1.5% 27.6% 26.7% 28.7% 3.2 x 3.1 x 12.0 x 11.0 x

Computer Sciences Corporation 63.05 94% 9,052 1,923 892 9,944 12,858 0.7% 25.2% 16.4% 17.2% 0.8 x 0.8 x 4.7 x 4.5 x

Aspen Technology, Inc. 35.02 72% 3,187 265 (265) 2,921 414 12.0% 85.3% 38.4% 42.7% 7.0 x 6.3 x 18.4 x 14.8 x

25th percentile 2.5% 35.0% 25.3% 27.0% 2.8 x 2.7 x 9.1 x 8.4 x

Median 3.8% 61.3% 30.4% 30.6% 3.9 x 3.7 x 12.0 x 11.0 x

75th percentile 7.7% 67.4% 36.4% 38.8% 4.5 x 4.3 x 14.1 x 12.8 x

Healthcare IT - Europe

CompuGroup Medical AG 24.09 93% 1,198 29 408 1,606 628 4.5% 37.4% 19.8% 22.5% 2.6 x 2.4 x 12.9 x 10.9 x

Advanced Computer Software Group plc 2.16 99% 1,144 16 58 1,202 339 6.3% 50.5% 22.1% 23.5% 3.5 x 3.3 x 16.0 x 14.2 x

EMIS Group PLC 13.56 100% 856 12 7 863 212 6.7% 48.5% 31.2% 31.8% 4.1 x 3.8 x 13.0 x 12.0 x

Cegedim SA 35.32 99% 493 63 611 1,104 1,091 (31.7%) 45.1% 17.5% 19.7% 1.0 x 1.5 x 5.8 x 7.5 x

Servelec Group plc 4.63 99% 320 15 (23) 297 86 28.8% 43.8% 22.3% 22.9% 3.5 x 2.7 x 15.5 x 11.7 x

Craneware plc 7.42 75% 200 33 (33) 167 44 12.4% 95.2% 28.8% 29.0% 3.8 x 3.4 x 13.1 x 11.6 x

Allocate Software plc. 2.42 98% 171 14 (21) 149 26 55.4% 71.0% 38.7% 28.0% 5.8 x 3.7 x 14.9 x 13.2 x

25th percentile 5.4% 44.5% 21.0% 22.7% 3.0 x 2.6 x 13.0 x 11.2 x

Median 6.7% 48.5% 22.3% 23.5% 3.5 x 3.3 x 13.1 x 11.7 x

75th percentile 20.6% 60.8% 30.0% 28.5% 3.9 x 3.5 x 15.2 x 12.6 x

Healthcare IT - US

McKesson Corporation 207.58 97% 48,911 3,804 8,363 57,274 167,582 9.0% 6.0% 2.6% 2.8% 0.3 x 0.3 x 13.0 x 11.2 x

Cerner Corporation 64.66 97% 23,115 1,332 (1,185) 21,930 3,381 26.7% 84.3% 33.5% 32.0% 6.5 x 5.1 x 19.3 x 16.0 x

CareFusion Corporation 59.34 100% 12,345 1,736 255 12,600 3,955 4.8% 50.8% 23.7% 25.2% 3.2 x 3.0 x 13.4 x 12.1 x

IMS Health Holdings, Inc. 25.64 90% 8,773 354 3,561 12,334 2,644 5.8% 54.1% 33.1% 33.7% 4.7 x 4.4 x 14.1 x 13.1 x

athenahealth, Inc. 145.70 70% 5,761 105 108 5,868 747 23.0% 59.9% 18.6% 18.0% 7.9 x 6.4 x 42.2 x 35.5 x

Allscripts Healthcare Solutions, Inc. 12.77 65% 2,302 37 550 2,852 1,399 5.6% 45.1% 14.5% 16.6% 2.0 x 1.9 x 14.1 x 11.7 x

MedAssets, Inc. 19.76 76% 1,203 14 895 2,097 716 5.9% 77.7% 33.1% 33.5% 2.9 x 2.8 x 8.8 x 8.3 x

Castlight Health, Inc 11.70 28% 1,056 182 (182) 874 44 83.5% (33.4%) (173.7%) (85.5%) 19.8 x 10.8 x n.m. n.m.

Quality Systems Inc. 15.59 74% 940 124 (124) 816 474 7.4% 56.0% 14.5% 15.7% 1.7 x 1.6 x 11.9 x 10.2 x

Healthstream Inc. 29.48 85% 835 116 (116) 718 171 17.6% 58.0% 16.6% 16.9% 4.2 x 3.6 x 25.3 x 21.1 x

Computer Programs & Systems Inc. 60.75 85% 681 29 (29) 652 210 3.1% 46.7% 27.9% 28.4% 3.1 x 3.0 x 11.1 x 10.6 x

Merge Healthcare Incorporated 3.56 97% 342 34 194 536 215 4.0% 58.6% 22.1% 23.0% 2.5 x 2.4 x 11.2 x 10.4 x

25th percentile 5.2% 48.8% 15.5% 16.7% 2.7 x 2.6 x 11.4 x 10.5 x

Median 5.9% 56.0% 22.1% 23.0% 3.2 x 3.0 x 13.8 x 11.9 x

75th percentile 20.3% 59.2% 30.5% 30.2% 5.6 x 4.8 x 18.0 x 15.3 x

Biopharma IT

Veeva Systems Inc. 26.41 66% 3,429 393 (393) 3,036 303 26.7% 60.4% 27.6% 27.4% 10.0 x 7.9 x 36.3 x 28.8 x

Medidata Solutions, Inc. 47.75 70% 2,675 258 (20) 2,655 337 21.4% 74.7% 22.3% 24.0% 7.9 x 6.5 x 35.4 x 27.0 x

Instem plc 2.06 66% 25 - - 28 20 6.5% 18.1% 13.7% 16.8% 1.2 x 1.2 x 9.1 x 7.0 x

25th percentile 13.9% 39.3% 18.0% 20.4% 4.6 x 3.8 x 22.2 x 17.0 x

Median 21.4% 60.4% 22.3% 24.0% 7.9 x 6.5 x 35.4 x 27.0 x

75th percentile 24.1% 67.6% 24.9% 25.7% 8.9 x 7.2 x 35.8 x 27.9 x

EBITDA Margin

HealthTech: Selected Publicly Traded Companies

12

Note: Calendarised to December year end; $ millions, except share price data; Multiples capped at 20x EV / Revenue and 50x EV / EBITDA; Net debt includes minority interest

Note: (1)

McKesson excluded from ‘Healthcare IT – US’ summary analysis above because majority of revenue is generated from pharmaceutical distribution

Note: (2)

Castlight Health has run a negative gross margin during a period of rapid growth due to additional implementation costs associated with launching new customers

Note: (3)

Cegedim’s revenue growth and EBITDA multiples reflect the divestiture of its Information and CRM solutions assets to IMS Health in June 2014

Source: Capital IQ

(2)

(1)

(2)

(3)

27 Soho Square, London, W1D 3AY

t +44 20 7629 7575 | f +44 20 7629 2233

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Chris Lewis

Managing Director

Di: +44 (0) 20 7514 8236

E: [email protected]

13

Richard Latner

Manager

Di: +44 (0) 20 7514 8241

E: [email protected]

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