hcv update
DESCRIPTION
HCV update. Ardis Ann Moe UCLA CARE clinic/NEVHC Van Nuys 21 June 2014 [email protected]. Goals:. 1) terminology of hep C 2) benefits of hep C treatment 3 )drug interaction issues with HIV meds - PowerPoint PPT PresentationTRANSCRIPT
![Page 2: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/2.jpg)
1) terminology of hep C 2) benefits of hep C treatment 3)drug interaction issues with HIV meds
My thanks to my colleague Debika Bhattacharya for use of her slides for this presentation.
Goals:
![Page 3: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/3.jpg)
Terminology
![Page 4: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/4.jpg)
Hep C viral load is not the same as HIV viral load◦ Hep C viral load does not correlate with risk of
death, cirrhosis, liver damage.
![Page 5: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/5.jpg)
Hep C can be cured with current medications, unlike HIV. ◦ Cure=SVR “sustained virological response”◦ Hep C viral load 6 months after completing
treatment is undetectable = SVR
![Page 6: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/6.jpg)
CHILD score: A, B or C.(also scored numerically:5 or more points) ◦ Risk of death from cirrhosis. ◦ Only to be used in patients with documented
cirrhosis◦ Important since simeprevir contraindicated in
patients with CHILD score>5.(or B or C)◦ Website for calculator for CHILD score:◦ :http://www.mdcalc.com/child-pugh-score-for-
cirrhosis-mortality/
![Page 7: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/7.jpg)
Benefits of Hep C Treatment
![Page 8: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/8.jpg)
Patients who do develop cirrhosis have many problems: ◦ Esophageal varices and recurrent internal
bleeding◦ Ascites (fluid on the abdomen)◦ Brain damage from hepatic encephalopathy◦ liver cancer◦ Problems with medications◦ Leg edema◦ Jaundice
![Page 9: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/9.jpg)
![Page 10: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/10.jpg)
![Page 11: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/11.jpg)
![Page 12: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/12.jpg)
![Page 13: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/13.jpg)
Even without cirrhosis, there are complications of hep C◦ Fatigue◦ Cryoglobulimia (kidney damage)◦ Porphyria cutanea tarda◦ Increased risk of diabetes
![Page 14: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/14.jpg)
![Page 15: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/15.jpg)
![Page 16: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/16.jpg)
Treatment of hep C reduces or eliminates risk of liver cancer, cirrhosis, cryoglobulinia, and porphyria.
However, cirrhosis is permanent scarring, so once there is cirrhosis, there is always some risk of liver cancer in the future, even if hep C cured.
Treatment of hepatitis C also appears to alleviate fatigue. Hepatology.2014 Apr 5
![Page 17: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/17.jpg)
![Page 18: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/18.jpg)
Treatment issues with HIV
![Page 19: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/19.jpg)
![Page 20: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/20.jpg)
![Page 21: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/21.jpg)
HCV DAA (direct acting antiviral) Cheat Sheet
◦ PREVIR Protease inhibitors: telaprevir, boceprevir, simeprevir
◦ BUVIR Polymerase inhibitors
Sofosbuvir
ASvir NS5A inhibitors: Daclatasvir, ledipasvir
![Page 22: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/22.jpg)
![Page 23: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/23.jpg)
![Page 24: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/24.jpg)
![Page 25: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/25.jpg)
IDSA Recommendations IFN-free:
Genotype 1: Sim/Sof x 12 weeks (+/- ribavirin)
Genotype 2: Sof/ribavirin x 12 weeks Genotype 3: Sof/ribavirin x 24 weeks Genotype 4: Sof/rifabirin x 24 weeks
![Page 26: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/26.jpg)
Simeprevir◦ Rash including photosensitivity (28%), itching
(22%), nausea (22%), shortness of breath (12%), elevated bilirubin (49%) Note rash more likely in patients with cirrhosis
Side effects:
![Page 27: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/27.jpg)
Sofusbuvir◦ Fatigue 59%◦ headache 36% ◦ insomnia 25% ◦ chills 17% ◦ irritability 13% ◦ rash 18% ◦ itching 27% ◦ nausea 34% ◦ diarrhea 11%
Side effects
![Page 28: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/28.jpg)
Side effects of interferon
![Page 29: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/29.jpg)
![Page 30: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/30.jpg)
Side effects of simepravir/sofobuvir
![Page 31: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/31.jpg)
![Page 32: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/32.jpg)
Overall <5% of study subjects stopped sofosbuvir and simeprevir on the COSMOS and other studies because of side effects.
![Page 33: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/33.jpg)
Daclatasvir: effective against genotypes 1,2,3 Ledipasvir: effective against genotype 1; to be combined with sofosbuvir into 1 pill a day
Hep C meds to be approved
![Page 34: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/34.jpg)
![Page 35: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/35.jpg)
![Page 36: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/36.jpg)
HIV/Hep C Drug interactions
![Page 37: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/37.jpg)
![Page 38: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/38.jpg)
find those patients who need to be treated NOW with simeprevir/sofosbuvir, and who are willing to be on a limited HIV regimen (complera, isentress, truvada) in order to prevent drug interactions
Patients who are on Atripla, Stribild, or boosted protease inhibitors will have to wait until more hep C drugs available.
![Page 39: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/39.jpg)
Treat HIV first if CD4 <500 and get HIV viral load <50 copies for maximal response from hep C meds
If CD4 count >500, may be able to wait on starting HIV meds until after hep C treatment completed.
![Page 40: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/40.jpg)
Treatment Schema
![Page 41: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/41.jpg)
Obtain baseline hep C viral load (within 3 months of beginning treatment)
Counsel patient on need to take all meds
Counsel patient on need to avoid sunlight, risks of nausea and rash
Alter patient’s HIV regimen if necessary.
![Page 42: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/42.jpg)
Follow-up 2 weeks and at 4 week point after initiating hep C meds to check on adherence and immediate side effects. Mild rash can be treated through with benedryl, topical steroids
Check CBC, platelets, AST, ALT every 2 weeks during first 4 weeks.
Repeat Hep C viral load at Week 4 point
![Page 43: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/43.jpg)
Hep C viral load should be <25 copies at Week 4 point; if not, patient may need to be discontinued to prevent resistance.
Recheck hep c viral load at Week 8.
If hep c meds tolerated, see patient at Week 4, Week 8 and Week 12 and check CBC, platelets, AST, and ALT at each visit(or monthly if being treated x 24 weeks)
![Page 44: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/44.jpg)
If patient on ribavirin containing regimen, dose reduce ribavirin if anemia develops: Hb < 10
Most anemia with Sof/ribavirin mild.
![Page 45: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/45.jpg)
Repeat Hep C viral load 6 months after completing therapy to ascertain cure: “SVR”.
![Page 46: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/46.jpg)
Audience Response Question: Which is FALSE
5%
9%
50%
36% 1)hep C viral load of 2,000 copies may be a patient undergoing self-cure
2)a patient who is cured of hep C but still has cirrhosis has no risk of liver cancer
3)simeprevir has multiple drug interactions with many HIV medications
4)patients cured of hep C have less fatigue
![Page 47: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/47.jpg)
Reinfection
![Page 48: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/48.jpg)
191 MSM with cured (treated with meds) or spontaneously cleared hep C◦ 44 were reinfected◦ 8 were infected several more times◦ Same or different genotypes◦ None had IDU risk factor◦ Estimated that 25% will be re-infected within 2
years of cure.
◦ AIDS 2013 Oct 23;27(16):2551-7
Study of reinfection rates
![Page 49: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/49.jpg)
Prison populations in Spain:◦ 119 Hep C Ab+, cured or spontaneously cleared
while as inmate. 81% hx of IDU◦ Reinfection rate 5.37 per 100 person years, higher
in active IDU and HIV co-infected
◦ J Hepatology. 2013 July;59(1):45-51
![Page 50: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/50.jpg)
Selection of patients for hep C treatment will have to include safe sex counseling and sobriety
![Page 51: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/51.jpg)
Conclusions
![Page 52: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/52.jpg)
Interferon free hep C drugs are here, and more coming
Be prepared for elaborate PA process to get the meds
Treatment will reduce complications of hep C infection and improve quality of life
Select patients who are not likely to get re-infected and will adhere to frequent clinic visits during treatment.
![Page 53: HCV update](https://reader031.vdocuments.site/reader031/viewer/2022020921/56814ba8550346895db87f4d/html5/thumbnails/53.jpg)