hansen’s diseases[1].pdf · cause claw hand deformity • lower extremities – examine for loss...
TRANSCRIPT
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HANSEN’S DISEASE
By Stephanie Burns, RN, DNC
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Objectives
• To discuss brief history of Hansen’s disease
• To discuss how to diagnose Hansen’s disease
• To explain classifications of Hansen’s disease
• To discuss reactions in Hansen’s disease
• To discuss treatment of Hansen’s disease
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HANSEN’S DISEASE
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HISTORY • 1.) Leprosy is a chronic
infectious disease caused by Mycobacterium leprea bacteria.
• 2.) The earliest descriptions recorded about 600 BC in India.
• 3.) 1873 Gerhard Hansen, a Norwegian physician, was recognized as first person to identify the bacterium, Mycobacterium leprae, as the cause of the disease.
• 4.) During this period until early 1900’s leprosy was treated with hydrocarpus oil. This oil was extracted from dried fruit of the hydrocarpus tree.
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• 5.) Leper colonies have existed since the Middle Ages with purpose to isolate lepers and prevent spreading the disease.
• 6.) 1941 sulfone, (promin), was introduced to treat HD. Although this medication is reported as being somewhat successful in curing HD, it was administer IM and quite painful.
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• 7.) 1950 dapsone became the standard
treatment for HD
• 8.) 1982 The World Health Organization
recommended multidrug therapy (MDT)
with dapsone, rifampin, and clofazimine.
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• 1995 WHO has made MDT available free
of charge to all patients worldwide
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DEFINITION OF PREVALENCE
OF LEPROSY
• Refers to estimated population of
people who are managing Leprosy at a
given time
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DEFINITION OF INCIDENCE OF
LEPROSY
• Refers to the annual diagnosis rate or
the number of new cases of Leprosy
diagnosed each year
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• Currently Brazil, Madagascar,
Mozambique, Tanzania and Nepal are
listed as having 90% of the Hansen’s
disease cases.
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Beginning of 2008 – Global registered prevalence of leprosy = 212,802. New cases detected during 2007 was 254,525
2011 - global prevalence registered at
192,246 cases. New cases detected during
2010 was 228,474 (excludes small # of cases
in Europe.
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U.S. DATA
• 6500 cases of Leprosy in U.S.
• 90% immigrants from countries where disease is endemic.
• 600 cases with active disease and requiring drug treatment
• 200 – 250 cases reported each year.
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U.S DATA CONTINUED
• The Largest #’s of
Leprosy cases in
U.S. are in
• California
• Texas
• Hawaii
• Louisiana
• Florida
• New York
• Puerto Rico
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LAHEY CLINIC DATA
2010 2011 2012
Pts on Roster---269 --------272 --------276
Newly Dx-----------6------------4------------3
Active Status-----95-----------99---------102
Brazilian Pts--------6------------4------------2
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REASONS FOR DECREASE
IN REGISTEREDED CASES
• Shortened treatment period and revised definition of a case of HD. Current definition of a case, according to WHO is a patient requiring chemotherapy.
• Therefore, patients who have completed their chemotherapy are no longer counted as cases.
• In summary the number of cases on treatment has decreased over the last decade but the new cases have not dramatically decreased
.
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RISK FACTORS
• Highest risk for population living in
endemic areas with poor living conditions,
contaminated water, poor diet.
• Individuals with compromised immune
system
• Men are two times more likely to contract
leprosy than women
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• Usual source of infection is from
patients with untreated lepromatous HD.
Large amounts of bacilli can be found in
their upper respiratory tract and nasal
mucus membranes.
• More prevalent with prolonged and/or
close contact with patient.
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• Transmission of M leprae is through droplet or dust.
• M leprae can remain viable,outside the body, for 24 hours to several days.
• There is no evidence of sexual transmission.
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• Armadillos found in Texas and
Louisiana, have been found to be
infected with M leprae. Therefore
are suspected of being a source of
transmission of the disease to
humans.
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• Heredity theory effecting the immune system. Some
family members have predisposition to disease.
(Example:Why one sibling exposed to the disease
will become infected, while another sibling having
same exposure will not contract HD)
• Incubation period once infected by m leprae can be
from 6 months to 40 yrs.
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DIAGNOSIS
• THREE CARDINAL SIGNS
1.) Anesthesia
2.) Enlarged nerves
3.) Acid-fast bacilli
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DIAGNOSIS CONTINUED
• Localized lesion
– Hypopigmented
– Hyperpigmented
– Erythematous
– Sensation loss
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• Nerve involvement is always present in HD
• Bacilli can be found in nerves at almost any
level from periferal nerves to the larger
proximal nerve trunks.
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• Acid bacilli can be detected in skin
through:
skin smears
skin bx
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PERIPHERAL NERVES
• FACIAL
• GREAT AURICULAR
• MEDIAN
• ULNAR
• RADIAL
• RADIAL CUTANEOUS
• PERONEAL
• POST TIBIAL
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• Bacilli tend to accumulate in the cooler parts of the body
– Ears
– Forehead
– Chin
– Nose
– Eye
– Elbow
– Wrist
– Knee
– Testicles
– Ankle
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• Nerves are usually superficial, enlarged,
painful and can be palpated easily.
• Damage to the nerves cause sensory,
and motor damage
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• Skin - Skin lesions should be tested with monofilament or article that is able to give a light touch, such as a cotton wisp or feather. This test will indicate if patient has anesthesia within skin lesions.
• Eyes – look for signs of redness, tenderness or evidence of lid weakness, which can cause drooping of eye lid (lagophthalmus).
Examination of the skin, eyes, hands, and
feet.
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DIAGNOSIS CONTINUED
• Hands – observe for
loss of sensation,
weakness of the
intrinsic muscles of
the hand or muscle
atrophy which can
cause claw hand
deformity
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• Lower extremities –
examine for loss of
sensation, muscle
atrophy, foot drop, or
claw toes. Due to
insensitive feet
always check for
pressure or trauma
ulcers.
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CLASSIFICATION OF
HANSEN’S DISEASE
• Two systems of classification • 1.)Ridley and Jopling classification
» Clinical
» Immunology
» Histology
» Bacteriology
• 2.) the WHO two group classification
» Pausibacillary
» Multibacillary
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Ridley and Jopling
classification
Based on immunologic response of the host to M leprae
Indeterminate
– TT (polar tuberculoid)
– BT (borderline tuberculoid)
– BB (borderline)
– BL (borderline lepromatous
– LL (lepromatous)
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CLASSIFICATION OF LEPROSY
BY WHO • 11) Single lesion
Paucibacillary HD - • (SLPB)
• 2) Paucibacillary HD –
• PB
• 1 lesion, no trunk involvement, sensory loss within lesion
• 2-5 # lesions, generally asymmetrical distribution with definite loss of sensation and no more than 1 nerve trunk involvement
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WHO CLASSIFICATION
CONTINUED
• Multibacillary (MB) – • More than 5 lesions
with more or less
symmetrical
distribution, loss of
sensation in various
areas and may have
many nerve trunks
involved
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HD spectrum
Classification Zones of the HD
spectrum
_________________________________
Ridley – Jopling TT BT BB BL LL
WHO Classification PB MB
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Indeterminate
• One or few vague lesions
• Hypopigmented or erythematous
macules
• Favors extremities, buttock, or face
• Minimally impaired sensation
• No peripheral nerve enlargement
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TUBERCULOID
TT - Polar • One or few lesions
• Sharply marginated,
scaling macules or
plaques, sometimes
elevated edges
• Lesions anesthetic
• Sometimes enlarged
nerve in area of
lesion
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BODERLINE TUBERCULOID
(BT) • Few to many
erythematous,
hypochromic
plaques with scaling
surface with well
defined margins
which may have
small satellite
lesions, usually
annular
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BT continued
• Lesions anesthetic asymmetrical
• Several peripheral nerves involved
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BODERLINE
(BB)
• Several succulent
plaques with sharply
demarcated central
area and edges sloping
into surrounding normal
skin
• Large erythematous
irregular infiltrated
bands with central
uninvolved anesthetic
areas
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(BB) continued
• Moderate anesthetic lesions widespread
and asymmetrical peripheral nerve
involvement
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BODERLINE
LEPROMATOUS
(BL)
• Many roughly symmetrical
shiny, erythematous and
sometimes hypopigmented
macules, papules, nodules with
sloping edges.
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(BL) continued
• Lesions slightly anesthetic
• Widespread and less asymmetrical
peripheral nerve involvement
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LEPROMATOUS LEPROSY
(LL)
• Early (LL) --
• 1) Macules small,
multiple and
symmetrical
• 2) Smooth shiny
surface with
indistinct margins
• 3) faintly
erythematous to
copper - colored
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EARLY (LL) CONTINUED
• Macules become more evident after
exposure to sun
• Eyebrow hair is sparse
• Lesions hazy, indistinct and
asymptomatic
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INFILTRATED (LL)
• 1) Succeeds macular form
• 2) Skin is thickened, erythematous and shiny
• 3) Infiltrated plaques are glossy, soft and slope towards periphery
• 4) Sensory loss slight in infiltrated areas
• 5) Skin lesions generalized but do not occur in axilla and groin areas
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(LL) continued
• Madarosis of eyebrows
• Nasal mucosal ulceration
• Usually no sensory impairment in early
stages
• Later symmetrical peripheral neuropathy of
arms and legs with stocking and glove
anesthesia and of facial nerve
• Eye involvement (conjunctiva, cornea,and
iris)
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LEPROMATOUS
(LL) • Multiple and
symmetrical erythematous and copper colored macules, later indurations followed by nodulation of face, especially ears and nose,extremeties,joints
• and trunk
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REACTIONS IN HD
1) Reversal Reaction
BT
2) Erythema Nodosum Leprosum (ENL)
BL
LL
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Reversal reaction Sx
– 1) Edema and erythema of previously
visible skin lesions.
– 2) Sudden nerve damage, with swelling
and pain
– 3) Fever
– 4) New, well-defined erythematous skin
lesions
– 5)Edema of hands and feet
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BT IN REACTION
• Allergic reaction causes edema
• Body crying to get rid of dead
organisms
• Body is truly getting better
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ENL SX’S
• 1) Red, tender, painful nodules
• 2) Fever, malaise
• 3) Painful neuritis, arthritis,
lymphadenopathy
• 4) Eye involvement –iritis, scleritis
• 5) Edema of extremities
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EYE INVOLVEMENT
WITH ENL
• Infiltration of dead
organisms into eye
• Nodules in iris
• Distorted pupil from
reactions
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LUCIO HD
• 1) Diffuse LL
• 2) Patients of
Mexican and Costa
Rican origin
• 3) No nodules
• 4) No wrinkles
• 5) No sweat
• 6) No body hair » Bonita (pretty
in Spanish)
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LUCIO PHENOMENON
REACTION
• Vessels become
plugged causing
vasculitis
• Severe ulcerations
of skin
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US TREATMENT PLAN
• PAUCIBACILLARY
– Treat for 1 yr Rifampin 300mg – 600mg daily
Dapsone 100mg daily
Follow for 5 yrs
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US TREATMENT CON’T
• Multibacillary
• Treatment for 2 yrs - Rifampin 300mg – 600mg
Dapsone 100mg daily
Clofazimine 50mg daily
» Follow for 5 – 10 years
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ADVANTAGES OF MDT
• Isolation of patient is not necessary.
Disease is very difficult to transmit to
another person.
• Patient is non communicable once
started on MDT.
• Relapse is rare
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TREATMENT OF
REACTIONS
• Reversal Reaction • Analgesics for nerve
pain
• Prednisone for
severe reaction
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TREATMENT OF REACTIONS
CONTINUED
• ENL • Prednisone 40 – 80
mg
– Daily single dose
– After reaction
controlled, slow
tapering 5mg
every 1-2 weeks
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TREATMENT OF REACTIONS
CONTINUED
• ENL • Thalidomide 50 –
200mg daily
• Clofazimine 300mg
daily for 4 – 6
wks reduced to
200 mg for several
months
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Clofazimine continued
• When prednisone is discontinued for 3
months then Clofazimine can be
reduced to
• 50 mg daily
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FOLLOW UP AFTER
COMPLETION OF TREATMENT
• Paucibacillary (PB)
–Every six months for two years
–Annually for three years
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FOLLOW UP AFTER
COMPLETION OF TREATMENT
• Multibacillary (MB)
–Every six months for two years
–Annually for eight years
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CASE STUDY
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HISTORY
• 34-year-old Portuguese speaking male
from Brazil
• Entered U.S. June 2005. At that time
started working on farm in N.H. doing
landscaping
• Spring of 2006 noted a few “mosquito
bites” on his arms that itched and turned
red.
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HISTORY CONTINUED
• Red bumps started on arms,
progressively more involved on his
lower legs, trunk and face.
• Wife sent him medication from Brazil
called Meticorten (prednisone), which
he took for several months, with more
swelling of his skin lesions.
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HISTORY CONTINUED
• Therefore stopped this medication
around April 2007.
• Patient saw local Dermatologist May
2007
– Presented with diffuse large fleshy nodules
on face, arms, legs, trunk, back of neck
and ears.
– Lesions on trunk were hyperpigmented, flat
and diffuse
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PHYSICAL EXAM
- Lesions on knees dry with light scale
- Hands diffusely swollen with lesions that are more erythematous
- Normal ear canals.
- Skin lesion extruding from right lower eyelid. – Lesion on posterior soft palate.
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• WHAT COULD BE DONE TO
SUPPORT
CLINICAL DIAGNOSIS?
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• Skin Biopsy
• Skin Smears
• Palpate Enlarged Nerves
• Sensory Testing
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BIOPSY RESULTS
• Shave biopsy skin of left abdomen
– Lepromatous Leprosy
– Fite stains reveal numerous mycobacteria
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FOOT AND HAND SCREENING
• Multiple foot ulcers
• Feet swollen
• No weakness in ankle or foot
• No loss of protective sensation
• Hands residual texture with sensory
testing
• No muscle weakness
• No tender nerves
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TREATMENT PLAN
• Clofazimine 100mg daily
• Rifampin 300 mg daily
• Ofloxacin 400mg daily
• Prednisone 20 mg daily
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REFERRALS
• Infectious Disease
• Otolaryngology
• Ophthalmology
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FURTHER DIAGNOSTIC TESTS
• G6PD
• CBC
• LFT’s
• Eosinophilia
• Hep B Surg AB
• Strongylidiasis AB
• Stools O & P
• Crypto/Giardia
• PPD
• CXR
• Cat Scan/Thorax
• Toxocara Canis AB
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Foot drop & ulnar damage
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IMPORTANT LESSON TO
REMEMBER
• Leprosy can be cured
• Leprosy is a slow disease
• Leprosy takes a long time to come and
a long time to go away
• Medication can cure leprosy patches,
but not deformity
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SUGGESTED READING
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CHINESE PROVERB
• “What we hear, we forget,
• What we see, we remember,
• What we do, we know.”
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