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H A N G ( H U B E R T ) Y I N

W o r k A d d r e s s : 2 6 0 C r i s t o l C h e m i s t r y & B i o c h e m i s t r y U n i v e r s i t y o f C o l o r a d o a t B o u l d e r B o u l d e r , C o l o r a d o 8 0 3 0 9 - 0 2 1 5 , U S A T e l e p h o n e : + 1 ( 3 0 3 ) 4 9 2 - 6 7 8 6 ; F a c s i m i l e : + 1 ( 3 0 3 ) 4 9 2 - 5 8 9 4

E - m a i l : H U B E R T . Y I N @ C O L O R A D O . E D U

W e b s i t e : H T T P : / / W W W . C O L O R A D O . E D U / C H E M / Y I N L A B /

EDUCATION September, 1999 - August, 2004

Yale University (New Haven, CT) Ph. D. in Organic/Bioorganic Chemistry Thesis Title: “Development of Low-Molecular-Weight Antagonists of Protein-Protein Interactions: Alpha-Helix

Mimicry in Drug Discovery” Thesis Advisor: Professor Andrew D. Hamilton, Ph.D., FRS September, 1995 - July, 1999 Peking University (Beijing, China) B.S. in Applied Chemistry

EMPLOYMENT August, 2007 - Present

University of Colorado at Boulder (Boulder, CO) Assistant Professor of Chemistry and Biochemistry Member of the Biofrontiers Institute October, 2004 – July, 2007 University of Pennsylvania School of Medicine (Philadelphia, PA) Post-doctoral Associate Mentor: Professor William F. DeGrado, Ph.D. Co-Mentor: Professor Joel S. Bennett, M.D.

ACADEMIC RECOGNITIONS NSF CAREER Award, National Science Foundation (2010)

SU2C IRG Award, Stand Up to Cancer (2010) Gertrude B. Elion Award, American Association for Cancer Research (2009) Early Career Award in Chemistry of Drug Abuse and Addiction, NIDA (2009) New Inventor of the Year, University of Colorado (2009) Cutting-Edge Basic Research Award, NIDA (2009) Collaborative Innovation Award, Howard Hughes Medical Institute (2009) Young Academic Investigators Symposium, American Chemical Society (2009)

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Research Grant Award, Children’s Leukemia Research Association, Inc (2009) Finn Wold Travel Award, the Protein Society (2009) Kimmel Scholars Award, Sidney Kimmel Foundation (2008) Junior Faculty Development Award, University of Colorado (2008) Pediatric Cancer Research Grant Award, Association for Research of Childhood Cancer (2008) Dean's Fund for Excellence, CU College of Arts and Sciences (2008) Wood-Whelan Fellowship, International Union of Biochemistry & Mol. Biology (2007) Young Investigator Scholarship, Alzheimer’s Drug Discovery Foundation (2007) Most Cited Paper 2004-2007 Award, Elsevier (2007) Gordon Research Conference Travel Award (2006) Scholarship for Outstanding Academic Achievement, Peking University (1998, 1997) Outstanding Freshman Scholarship, Peking University (1996) Member of the National Biology Olympiad Team (1995) RADO Science Genius Junior Award (1994)

JOURNAL PUBLICATIONS (37, H-INDEX = 16, AVERAGE CITATIONS=31.9) Independent Career (*corresponding author)

1. Miyauchi, K.; Urano, E.; Takeda, S.; Murakami, T.; Okada, Y.; Cheng, K.; Yin, H.; Masato, K.; Komano, J. “Toll-Like Receptor 3 as a Potential Surrogate Sensor of Retroviral Infection in Human Cells”, Retrovirology 2012, 9, in press.

2. Wang, X. H.; Loram, L. C.; Ramos, K.; de Jesus, A.; Thomas, J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.; *Yin, H. “Morphine: the new endotoxin”, Proc. Natl. Acad. Sci. U. S. A. 2012, 109, in press.

3. Morton, L. A.; Saludes, J. P.; *Yin, H. “Constant Pressure-Controlled Extrusion Method for the Preparation of Nano-sized Liposomes”, J. Vis. Exp. 2012, in press.

4. Joce, C.; Wiener, A. A.; *Yin, H. “Multi-Tox: A ToxR-Based Assay for Multi-Pass Transmembrane Domain Oligomerization”, Biochim. Biophys. Acta 2011, 1808, 2948-2953.

5. Chavez, S. A.; Martinko, A. J.; Lau, C.; Pham, M. N.; Cheng, K.; Mollnes, T. E.; *Yin, H. “Development of β–Amino Alcohol Derivatives that Inhibit TLR4-Mediated Inflammatory Response as Potential Antiseptics”, J. Med. Chem. 2011, 54, 4659-4669.

6. Liu, L. P.; Ghosh, N.; Slivka, P. F.; Fiorini, Z.; Hutchinson, M. R.; Watkins, L. R.; *Yin, H. “An MD2 Hot-Spot Mimicking Peptide that Suppresses TLR4-Mediated Inflammatory Response In Vitro and In Vivo”, ChemBioChem 2011, 12, 1827-1831 (cover article).

7. Sammond, D. W.; Joce, C.; Takeshita, R.; McQuate, S.; Ghosh, N.; Martin, J. M.; *Yin, H. “Transmembrane Peptides Used to Investigate the Homo-Oligomeric Interface and Binding Hot-Spot of Latent Membrane Protein 1”, Biopolymers 2011, 95, 772-784 (cover article).

8. Joce, C.; Wiener, A. A.; *Yin, H. “Transmembrane Domain Oligomerization Propensity Determined by ToxR Assay”, J. Vis. Exp. 2011, 51, 2721.

9. Cheng, K.; Wang, X. H.; *Yin, H. “Small Molecule Inhibitors of the TLR3/dsRNA Complex”, J. Am. Chem. Soc. 2011, 133, 3764-3767.

10. Kazi, A.; Sun, J.; Doi, K.; Sung, S. S.; Takahashi, Y.; Yin, H.; Rodriguez, J.; Becerril, J.; Berndt, N.; Hamilton, A. D.; Wang, H. G.; Sebti, S. M. “The BH3 a-Helical Mimic BH3-M6 Disrupts Bcl-xL, Bcl-2 and Mcl-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-Dependent Manner”, J. Biol. Chem. 2011, 286, 9382-9392.

11. Joce, C. M.; Stahl, J. A.; Shridhar, M.; Hutchinson, M. R.; Watkins, L. R.; Fedichev, P. O.; *Yin, H. “Application of a Novel In Silico High Throughput Screen to Identify Selective

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Inhibitors for Protein-Protein Interactions”, Bioorg. Med. Chem. Lett. 2010, 20, 5411-5413. 12. Bevan, D. E.; Martinko, A. J.; Loram, L. C.; Stahl, J. A.; Taylor, F. R.; Joshee, S.; Watkins, L.

R.; *Yin, H. “Selection, Preparation, and Evaluation of Small-Molecule Inhibitors of Toll-Like Receptor 4”, ACS Med. Chem. Lett. 2010, 1, 194-198.

13. Buchanan, M. M.; Hutchinson, M. R.; Watkins, L. R.; *Yin, H. “Toll-like Receptor 4 in CNS Pathologies”, J. Neurochem. 2010, 114, 13-27.

14. Hutchinson, M. R.; Loram, L. C.; Zhang, Y.; Schridhar, M.; Rezvani, N.; Phipps, S.; Foster, P. S.; Landgraf, K. E.; Falke, J. J.; Rice, K. C.; Maier, S. F.; Yin, H.; Watkins, L. R. “Evidence that Tricyclic Small Molecules May Posses Toll Like Receptor 4 and Myeloid Differentiation Protein 2 Activity”, Neurosci. 2010, 168, 551-563.

15. Hutchinson, M. R.; Lewis, S. S.; Coats, B. D.; Rezvani, N.; Zhang, Y.; Schridhar, M.; Wieseler, J. L.; Somogyi, A. A.; Yin, H.; Maier, S. F.; Rice, K. C.; Watkins, L. R. “Possible Involvement of Toll-Like Receptor 4/MD-2 Activity of Opioid Inactive Isomers Causes Spinal Proinflammation and Related Behavioral Consequences”, Neurosci. 2010, 167, 880-893.

16. Zhao, T. X.; Martinko, A. J.; Le, V. H.; Zhao, J.; *Yin, H. “Development of Agents That Modulate Protein-Protein Interactions in Membranes”, Curr. Pharm. Des. 2010, 16, 1055-1062.

17. Hutchinson, M. R.; Zhang, Y.; Schridhar, M.; Evans, J. H.; Buchanan, M. M.; Zhao, T. X.; Slivka, P. F.; Coats, B. D.; Rezvani, N.; Wieseler, J.; Hughes, T. S.; Landgraf, K. E.; Chan, S.; Fong, S.; Phipps, S.; Falke, J. J.; Leinwand, L. A.; Maier, S. F.; Yin, H.; Rice, K. C.; Watkins, L. R. “Evidence that Opioids May Have Toll Like Receptor 4 and MD-2 Effects”, Brain Behav. Immun. 2010, 24, 83-95.

18. Tang, J.; Yin, H.; Qiu, J.; Tucker, M. J.; DeGrado, W. F.; Gai, F. “Two Fluorescent Probes to Dissect the Binding, Insertion, and Dimerization Kinetics of a Model Membrane Peptide”, J. Am. Chem. Soc. 2009, 131, 3816-3817.

19. Slivka, P. F.; Shridhar, M.; Lee, G. I.; Sammond, D. W.; Hutchinson, M. R.; Martinko, A. J.; Buchanan, M. M.; Sholar, P. W.; Kearney, J. J.; Harrison, J. A.; Watkins, L. R.; *Yin, H. “A Peptide Antagonist of the TLR4/MD2 Interaction”, ChemBioChem 2009, 10, 645-649.

20. Li, Y.; Chase, A. R.; Slivka, P. F.; Baggett, C. T.; Zhao, T. X.; *Yin, H. “Design, Synthesis, and Evaluation of Biotinylated Opioid Derivatives as Novel Probes to Study Opioid Pharmacology”, Bioconjug. Chem. 2008, 19, 2585-2589.

21. Caputo, G. A.; Litvinov, R. I.; Li, W.; Bennett, J. S.; DeGrado, W. F.; *Yin, H. “Computationally Designed Peptide Inhibitors of Protein-Protein Interactions in Membranes”, Biochemistry 2008, 47, 8600-8606.

22. Slivka, P. F.; Wong, J.; Caputo, G. A.; *Yin, H. “Peptide Probes for Protein Transmembrane Domains”, ACS Chem. Biol. 2008, 3, 402-411 (highlighted in Chemical Biology Podcast).

23. *Yin, H. “Exogenous Agents that Target Transmembrane Domains of Proteins”, Angew. Chem. Int. Ed. 2008, 47, 2744-2752 (cover article).

Post-Doc and Ph.D. Works 24. Yin, H.; Slusky, J. S; Berger, B. W.; Walters, R. S.; Vilaire, G.; Litvinov, R. I.; Lear, J. D.;

Caputo, G. A.; Bennett, J. S.; DeGrado, W. F. “Computational Design of Peptides that Target Transmembrane Helices”, Science 2007, 315, 1817-1822 (featured in “News of the Week” Chem. Eng. News 2007, 85, 11; “News and Views” Nat. Biotech. 2007, 25, 646; and “Editors’ Choice” Sci. Signal. 2007, 2007, tw119).

25. White, T. C.; Berny, M. A.; Robinson, D. K.; Yin, H.; DeGrado, W. F.; Hanson, S. R.; McCarty, O. J. T. “The Leech Product Saratin is a Potent Inhibitor of Platelet Integrin a2b1 and von Willebrand Factor Binding to Collagen”, FEBS J. 2007, 274, 1481-1491.

26. Yin, H.; Litvinov, R. I.; Vilaire, G.; Zhu, H.; Li, W.; Caputo, G. A.; Moore, D. T.; Lear, J. D.;

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Weisel, J. W.; DeGrado, W. F.; Bennett, J. S. “Activation of Platelet αIIb β3 by Exogenous Peptides Corresponding to the Transmembrane Domains of αIIb”, J. Biol. Chem. 2006, 281, 36732-36741.

27. Yin, H.; Gerlach, L. O.; Miller, M. W.; Moore, D. T.; Liu, D. H.; Vilaire, G.; Bennett, J. S.; DeGrado, W. F. “Arylamide-Based Antagonists that Disrupt the Integrin α2β1-Collagen Interaction”, Bioorg. Med. Chem. Lett. 2006, 16, 3380-3382.

28. Yin, H.; Frederick, K. K.; Liu, D. H.; Wand, A. J.; DeGrado, W. F. “Arylamide Derivatives as Peptidomimetic Inhibitors of Calmodulin”, Org. Lett. 2006, 8, 223-225.

29. Yin, H.; Lee, G. I.; Sedey, K. A.; Kutzki, O.; Park, H. S.; Orner, B. P.; Ernst, J. T.; Wang, H. G.; Sebti, S. M.; Hamilton, A. D. “Terphenyl-Based Alpha-Helical Proteomimetics as Low-Molecular-Weight Antagonists of Bcl-xL”, J. Am. Chem. Soc. 2005, 127, 10191-10196 (recommended by the “Faculty of 1000” website as “Must Read”).

30. Yin, H.; Hamilton, A. D. “Strategies of Targeting Protein-Protein Interactions Using Synthetic Agents”, Angew. Chem. Int. Ed. 2005, 44, 4130-4163.

31. Yin, H.; Lee, G. I.; Park, H. Y.; Rodriguez, J. M.; Payne, G. J.; Sebti, S. M.; Hamilton, A. D. “Terphenyl Derivatives as Alpha-Helical Mimetics of P53”, Angew. Chem. Int. Ed. 2005, 44, 2704-2707 (chosen as a "Hot Paper" by the editors for its importance in a rapidly evolving field of high current interest).

32. Yin, H.; Lee, G. I.; Sedey, K. A.; Rodriguez, J. M.; Wang, H. M.; Sebti, S. M.; Hamilton, A. D. “Terephthalamide Derivatives as Mimetics of Helical Peptides: Disruption of the Bcl-xL/Bak Interaction”, J. Am. Chem. Soc. 2005, 127, 5463-5468.

33. Chen, L. H.; Yin, H.; Farooqi, B.; Sebti, S. M.; Hamilton, A. D.; Chen, J. D. “p53 Alpha-Helix Mimetics Antagonize P53/MDM2 Interaction and Activate P53”, Mol. Cancer Ther. 2005, 4, 1019-1025.

34. Yin, H.; Hamilton, A. D. “Terephthalamide Derivatives as Mimetics of the Helical Region of Bak Peptide Target Bcl-xL Protein”, Bioorg. Med. Chem. Lett. 2004, 14, 1375-1379 (recognized in the "Top-50 most cited articles" as published in Bioorg. Med. Chem. Lett. 2004-2007).

35. Sun, J.; Ohkanda, J.; Coppola, D.; Yin, H.; Kothare, M.; Busiglio, B.; Hamilton, A. D.; Sebti, S. M. “Geranylgeranyltransferase I Inhibitor, GGTI-2154, Induces Breast Carcinoma Apoptosis and Tumor Regression in H-Ras Transgenic Mice”, Cancer Res. 2003, 63, 8922-8929.

36. Ernst, J.T.; Becerril, J.; Park, H. S.; Yin, H.; Hamilton, A. D. “Design and Application of an Alpha-Helix-Mimetic Scaffold Based on an Oligoamide-Foldamer Strategy: Antagonism of the Bak BH3/ Bcl-xL Complex”, Angew. Chem. Int. Ed. 2003, 42, 535-539.

37. Kutzki, O.; Park, H. S.; Ernst, J. T.; Orner, B. P.; Yin, H.; Hamilton, A. D. “Development of a Potent Bcl-xL Antagonist Based on Alpha-Helix Mimicry”, J. Am. Chem. Soc. 2002, 124, 11838-11839.

BOOK CHAPTERS (4) 1. Lluis, M. W.; *Yin, H. “Combining Rational Design and the Directed Evolution: New

Approaches to Target Transmembrane Domains of Proteins” in Membrane Protein Design: Methods and Protocols (Senes, A.; Ghirlanda, G. Ed.), Springer-Verlag (Berlin Heidelberg), 2012, Methods in Molecular Biology (Walker, J. Ed.), in press.

2. Slusky, J. S.; Yin, H.; DeGrado, W. F. “Understanding Membrane Proteins. How to Design Inhibitors of Transmembrane Protein-Protein Interactions” in Protein Engineering (Köhrer, C.; RajBhandary, U. L. Ed.), Springer-Verlag (Berlin Heidelberg), 2009, Nucleic Acids and Molecular Biology (Gross, H. J. Ed.), 22, pp. 315-338.

3. Yin, H.; Hamilton, A. D. “Protein Secondary Structure Mimetics as Modulators of Protein-Protein and Protein-Ligand Interactions” in Chemical Biology: From Small Molecules to System

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Biology and Drug Design (Schreiber, S. L.; Kapoor, T. M.; Wess, G. Ed.), Wiley-VCH Verlag GmbH & Co. KGaA (Weinheim), 2007, 1, pp. 250-269.

4. Yin, H.; Lee, G. I.; Hamilton, A. D. “Alpha-Helix Mimetics in Drug Discovery” in Drug Discovery Research: New Frontiers in the Post-Genomic Era (Huang, Z. W. Ed.), John Wiley & Sons Inc. (New York), 2007, pp. 281-299.

MANUSCRIPTS IN REVIEW/REVISION (5) 1. Due, M. R.; Feldman, P.; Wilson, N.; Ripsch, M. R.; Chavez, S. A.; Yin, H.; Rajesh, K.; White,

F. A. “Neuroexcitatory Effects of Morphine-3-Glucuronide Is Dependent on Toll-Like Receptor 4 Signaling”.

2. Saludes, J. P.; Morton, L. A.; Ghosh, N.; Beninson, L.; Chapman, E. R.; Fleshner, M.; *Yin, H. “Cyclic Peptide Designed from Synaptotagmin I: Molecular Probe for Exosome Detection”.

3. Morton, L. A.; Saludes, J. P.; Fiorini, Z.; Beninson, L.; Chapman, E. R.; Fleshner, M.; *Yin, H. “MARCKS Peptide as a Membrane Curvature Sensor”.

4. Northcutt, A. L.; Hutchinson, M.R.; Hiranita, T.; Wang, X.; Lewis, S.; Kopajtic, T.A.; Loram, L.; Sfregola, C.; Galer, E.; Miles, N. E.; Bland, S. T.; Amat, J.; Rozeske, R. R.; Maslanik, T.; Chapman, T.; Strand, K.; Fleshner, M.; Bachtell, R. K.; Yin, H. J.; Katz, L.; Rice, K. C.; Maier, S.F.; Watkins, L. R. “Blockade of Opioid Reinforcement by (+)-Naloxone, a Toll-Like Receptor 4 Antagonist”.

5. Wang, X. H.; Zhao, T. X.; Saludes, J. P.; Fiorini, Z.; Lee, G. I.; Chavez, S. A.; Varga, K.; *Yin, H. “Targeting the Lateral Interactions of Transmembrane Domain 5 of Epstein–Barr Virus Latent Membrane Protein 1”.

PATENT APPLICATIONS (5) 1. Yin, H.; Saludes, J. P.; Morton, L. A. “Compositions, Methods And Uses For Peptides In

Diagnosis, Progression And Treatment Of Cancers”, Prov. USA Appl. 2011, No. 61/528,959. 2. Yin, H.; Cheng, K. “Modulators of TLR3/dsRNA Complex and Uses Thereof”, Prov.

Appl. 2011, 61/434,492; PCT Int. Appl. 2012, US2012/21207. 3. Yin, H.; Watkins, L. R. “Toll-Like Receptor Modulators”, Prov. Appl. 2009, 61/244,997; PCT

Int. Appl. 2010, US2010/050050 (licensed by BioLineRx, Israel). 4. Slusky, J. S.; Yin, H.; DeGrado, W. F. “Polypeptides that Bind to Membrane Proteins”, PCT

USA Appl. 2008, 12/306,424; PCT Int. Appl. 2007, US2007/015245. 5. Hamilton, A. D.; Yin, H. “Preparation of Terephthalamide Peptidomimetic Compounds for

Therapeutic Use”, PCT USA Appl. 2006, 60/818,094; PCT Int. Appl. 2005, US2005/005557.

EXTERNAL SERVICE AND ACTIVITIES Panelist/Study Section Reviewer: Regular and ad hoc panelist for the Chemistry of Life Processes

(CLP) NSF Division of Chemistry (2011/2012) Ad hoc Reviewer for Individual Grant Proposals: ACS Petroleum Research Fund, Biotechnology

and Biological Sciences Research Council (BBSRC), United States-Israel Binational Science Foundation (BSF), Canada Foundation for Innovation (CFI), Israel Science Foundation (ISF), CRDF Global, Medical Research Council (MRC), National Science Foundation (NSF), Yorkshire Cancer Research

Reviewer for Journals: ACS Combinatorial Science, ACS Medicinal Chemistry Letters, ACS Synthetic Biology, Anti-Infective Agents In Medicinal Chemistry, BBA-Biomembranes, Biomacromolecules, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Brain Research, Cell Adhesion & Migration, ChemBioChem, ChemMedChem, Current Medicinal Chemistry, European Journal of Medicinal Chemistry, Future Medicinal Chemistry, Journal of Combinatorial Chemistry, Journal of Medicinal Chemistry, Journal of

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Neuroscience, Journal of the American Chemical Society, Medicinal Research Reviews, Mini Reviews in Medicinal Chemistry, Molecules, Organic Letters, Proceedings of National. Academy of Sciences U. S. A., Protein Engineering Design & Selection, Science China Chemistry, Scientific Research and Essays, Tetrahedron

Conference Organization: Committee member for the 41st National Organic Chemistry Symposium (Boulder, 2009); Chair for the “Synthetic Biology and Drug Discovery” symposium at the BIT Life Sciences’ 1st World Congress of Molecular and Cell Biology (Beijing, 2011); Co-chair for the “Rational Drug Design vs. High Throughput Cancer Drug Screening” symposium at the BIT Life Sciences’ 2nd World Cancer Congress (Beijing, 2009); Co-chair for the “Transmembrane Peptides as Novel Therapeutics” symposium at the BIT Life Sciences’ 3rd PepCon-2010 (Beijing, 2010); Discussion Leader, Bioorganic Gordon Research Conference, Neuroscience and Neurological Disease Session (Andover, 2011)

Reviewer for Books: World Scientific Publishing, Imperial College Press, CRC Press/Taylor and Francis, Bentham Science Publishers, Roberts and Company Publishers

Scientific Advisory Boards: Cancer League of Colorado (2008 - Present), Boulder Valley School District (BVSD) Science Advisory Committee (2008 - Present)

Consulting Activities: Round Table Group, Inc. Guest Contributor for The Sceptical Chymist at www.nature.com.

INVITED SEMINARS 2012: University of Chicago, Institute for Biophysical Dynamics: Interdisciplinary Research

Seminar Series; University of California at San Diego, Department of Chemistry and Biochemistry; The Scripps Research Institute, Department of Chemistry; The Genomic Institute of the Novartis Research Foundation; University of Pennsylvania, Department of Chemistry; University of Wisconsin at Madison, Department of Biochemistry; Ohio State University, Department of Chemistry and Biochemistry; “Physics, Chemistry, and Biology of Membrane Proteins” Workshop (Tempe, AZ); Arizona State University, the Center for Biological Physics; University of Leeds, Drug Discovery Mini Symposium (Leeds, UK); University of New Mexico, Department of Chemistry; Colorado State University, Department of Chemistry; Boston College, Department of Chemistry; Syracuse University, Department of Chemistry; Indiana University School of Medicine, Stark Neurosciences Research Institute; SU2C Summit 2012; Wichita State University, Department of Chemistry.

2011: Tufts University, Department of Chemistry; University of South Florida, Department of Chemistry; Texas A&M, Department of Biochemistry & Biophysics; Tulane University, Department of Chemistry; Albert Einstein College of Medicine of Yeshiva University; Shanghai Jiao Tong University, School of Pharmacy; Feinberg School of Medicine, Northwestern University; NAKFI Synthetic Biology Mid-Cycle Grantee Meeting; AACR Special SU2C IRG Session (Orlando, FL); University of Toronto, Department of Chemistry; Vanderbilt University, Institute of Chemical Biology.

2010: National Institute of Biological Sciences; University of Colorado Cancer Center Molecular Oncology Program; Creighton University, Department of Chemistry; University of Colorado Cancer Center; 7th Annual AACR Gertrude B. Elion Cancer Research Award Lecture, AACR 101st Annual Meeting 2010 (Washington, DC); University of Denver, Department of Chemistry and Biochemistry; Peking University School of Chemical Biology & Biotechnology; BIT Life Sciences' 3rd Annual PepCon-2010 (Beijing, China); CU TTO Entrepreneurship Under the Microscope Panel; University of Colorado at Boulder, Chemical Biology Initiative.

2009: Beijing Capital Normal University, College of Life Sciences; The National Academes Keck Futures Initiative: System Biology Building on Nature’s Inspiration (Irvine, CA); CU “From Bench to Bedside” Family Weekend Symposium; University of Northern Colorado, Department of Chemistry & Biochemistry: University of Colorado at Boulder, Department of Chemistry & Biochemistry; ReceptorFest 09 (Boulder, CO); Shandong University, School of Life Sciences;

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Shandong University, School of Pharmaceutical Sciences; BIT’s 2nd Annual World Cancer Congress: Gateway to Future Medicine (Beijing, China); Young Academic Investigators Symposium, 237th ACS National Meeting (Salt Lake City, UT); University of Colorado at Denver and Health Sciences Center, Department of Biochemistry and Molecular Genetics.

2008: Nanjing University, School of Life Sciences; 27th Annual High School-University Chemistry Teachers’ Conference (Boulder, CO); The Center for Neurosciences at the University of Colorado; Hebrew University, Hadassah Medical School; Weizmann Institute of Science; Peking University, Health Science Center.

Prior to CU: Peking University, College of Chemistry and Molecular Engineering; Ohio State University, School of Pharmacy; University of Minnesota at Twin Cities, Department of Chemistry; University of California at Berkeley, Department of Chemistry; University of California at Irvine, Department of Chemistry; The Pennsylvania State University, Department of Chemistry; University of California at Davis, Department of Chemistry; UMass Medical School, Department of Biochemistry and Mol. Pharmacology; Brown University, Department of Chemistry; 34th Annual Phila. Workshop on Hemostasis, Thrombosis and Atherosclerosis (Philadelphia, PA); National University of Singapore, Department of Chemistry; University of Manchester, School of Pharmacy; 33rd Annual Phila. Workshop on Hemostasis, Thrombosis and Atherosclerosis (Philadelphia, PA).

PROFESSIONAL AFFILIATIONS Member of the Biofrontiers Institute at the University of Colorado (2011- present)

Biophysical Society (2011- present) The Protein Society (2009- present) The International Association for the Study of Pain (2009- present) American Association for Cancer Research (2007- present) University of Colorado Cancer Center (2007- present) Chinese-American Chemistry Professors Association (2007- present) Member of the Colorado Initiative in Molecular Biotechnology (2007- 2011) Center for Neuroscience at the University of Colorado (2007- present) Sigma Xi (2004- 2007) American Chemical Society (2000 - present)

AWARDED RESEARCH SUPPORTS Minimally Invasive Diagnostics of Metastatic Cancers in Body Fluids Agency: State of Colorado and University of Colorado Technology Transfer Office Award: Bioscience Discovery Evaluation Grant Program Duration: April 1, 2012 – September 30, 2013 PI: Hang (Hubert) Yin Total Amount Awarded: $200,000

Developing Novel Drug Candidates Optimizing Opiate's Clinical Efficacy Agency: State of Colorado and University of Colorado Technology Transfer Office Award: Bioscience Discovery Evaluation Grant Program Duration: April 1, 2011 – September 30, 2012 PI: Hang (Hubert) Yin

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Total Amount Awarded: $200,000 Drug Development for Novel Pain Management Therapies Agency: Colorado Center for Drug Discovery (C2D2) Duration: December 1, 2010 – July 31, 2011 PI: Hang (Hubert) Yin Total Amount Awarded: $50,000 CAREER: Promoting Chemical Biology Education and Research: Understanding Molecular Recognition in Membranes Agency: National Science Foundation (NSF) Award: Faculty Early Career (CAREER) Award (0954819) Duration: July 1, 2010 – June 30, 2015 PI: Hang (Hubert) Yin Total Amount Awarded: $625,000 Engineering Membrane Protein Inhibitors Through Rational Design and Directed Evolution Agency: W. M. Keck’s Foundation Award: NAKFI Seed Grant Duration: July 1, 2010 – June 30, 2012 PIs: Hang (Hubert) Yin, Clifford Wang (Stanford University) Total Amount Awarded: $100,000 Probing EBV-LMP-1's Transmembrane Activation Domain with Synthetic Peptides Agency: Stand Up to Cancer (SU2C) Award: SU2C Innovative Research Grants Duration: December 1, 2009 – January 1, 2013 PI: Hang (Hubert) Yin Total Amount Awarded: $727,339 Developing Small-Molecule Probes for Opioid-Induced Glial Activation Agency: National Institute of Neurological Disorders and Stroke (NIH/NINDS) Award: Optimization of Small Molecule Probes for the Nervous System (R21 NS067425) Duration: September 1, 2009 – August 31, 2011 (no-cost extension to August 31, 2012) PI: Hang (Hubert) Yin Total Amount Awarded: $454,500 Probing Opioid-Induced Glial Activation with Peptide Antagonists Agency: National Institute on Drug Abuse (NIH/NIDA) Award: Support Opportunity for Addiction Research for New Investigators (R03 DA027977) Duration: September 1, 2009 – August 31, 2011

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PI: Hang (Hubert) Yin Total Amount Awarded: $75,750 Optimizing the Clinical Efficacy of Opioids by TLR4 Blockade Agency: National Institute on Drug Abuse (NIH/NIDA) Award: Cutting-Edge Basic Research Awards (CEBRA) (R21 DA026950) Duration: July 1, 2009 – June 30, 2011 (no-cost extension to June 30, 2012) PI: Hang (Hubert) Yin Co-PIs: Linda R. Watkins (Psychology, CU-Boulder), Ora Schueler-Furman (Hebrew University of

Jerusalem), Jie-Oh Lee (KAIST) Total Amount Awarded: $274,616 Colorado Bioscience Proof-of-Concept Grant Agency: State of Colorado & Technology Transfer Office at the University of Colorado Duration: July 1, 2009 – March 31, 2011 (no-cost extension to September 30, 2011) PI: Linda R. Watkins (Psychology, CU-Boulder) Total Amount Awarded: $200,000 ($80,718 for the Yin Lab)

Multidisciplinary Analyses of the Activation of EBV LMP-1 Agency: American Association for Cancer Research (AACR)/GlaxoSmithKline (gsk) Award: AACR Gertrude B. Elion Cancer Research Award Duration: July 1, 2009 – June 30, 2010 PI: Hang (Hubert) Yin Total Amount Awarded: $50,000 Transforming Clinical Pain Control by Targeting a Novel Non-Neuronal Receptor Agency: National Institute on Drug Abuse (NIH/NIDA) Award: Early Career Award in Chemistry of Drug Abuse and Addiction (R03 DA025740) Duration: May 15, 2009 – April 30, 2011 PI: Hang (Hubert) Yin Total Amount Awarded: $378,750 Probing EBV-LMP-1's Transmembrane Activation Domain with Synthetic Peptide Antagonists Agency: National Cancer Institute (NIH/NCI) Award: Application of Emerging Technologies for Cancer Research (R21 CA138373/S1-3) Duration: April 1, 2009 – March 31, 2011 (no-cost extension to March 31, 2012) PIs: Hang (Hubert) Yin, Jennifer M. Martin (MCDB, CU-Boulder) Total Amount Awarded: $626,181 Optimizing the Clinical Efficacy of Opioids by TLR4 Blockade Agency: National Center for Research Resources (NIH/NCRR) Award: Colorado Clinical and Translational Research Institute Pilot Grant (UL1 RR025780) Duration: February 15, 2009 – February 14, 2010 PI: Hang (Hubert) Yin

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Total Amount Awarded: $20,000 Novel Transmembrane Peptide Probes to Investigate the Activation Mechanism of Integrin αIIbβ3 Agency: American Heart Association (AHA) Award: Pacific Mountain Beginning Grant-in-Aid (0960007G) Duration: January 1, 2009 – December 31, 2010 PI: Hang (Hubert) Yin Total Amount Awarded: $128,020 Chemical Biology Studies of the Activation Mechanism of EBV-LMP-1 Agency: Children’s Leukemia Research Association, Inc. Award: Research Grant Award Duration: January 1, 2009 – December 31, 2009 PI: Hang (Hubert) Yin Total Amount Awarded: $20,000 High Resolution Structural Studies of Membrane Proteins in Native Phospholipid Membranes Agency: Howard Hughes Medical Institute (HHMI) Award: Collaborative Innovation Award Duration: October 1, 2008 – September 30, 2012 PIs: Douglas C. Rees, Rob Phillips (Caltech), Hang (Hubert) Yin, & Michael H. Stowell (MCDB, CU-Boulder) Total Amount Awarded: $3,600,000 ($821,465 for the Yin lab) Acquisition of a Supercomputer by the Front Range Computing Consortium Agency: National Science Foundation (NSF) Award: Major Research Instrumentation Program (MRI) Duration: August 1, 2008 – July 31, 2011 PI: Henry Tufo (Computer Science, CU-Boulder) Total Amount Awarded: $2,796,500 (Yin is one of 57 senior personnel on this grant) Novel Peptide Probes to Study the Activation Mechanism of LMP-1 Agency: Sidney Kimmel Foundation for Cancer Research Award: Kimmel Scholars Award (SKF-08-101) Duration: July 1, 2008 – June 30, 2010 (no-cost extension to June 30, 2011) PI: Hang (Hubert) Yin Total Amount Awarded: $200,000 Multidisciplinary Approaches to Investigate EBV-Activation Agency: Cancer League of Colorado Duration: July 1, 2008 – June 30, 2009 PI: Hang (Hubert) Yin Co-PI: Jennifer M. Martin (MCDB, CU-Boulder)

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Total Amount Awarded: $60,000 Probing the Activation Mechanism of the LMP-1 Protein of Epstein-Barr Virus Agency: The Milheim Foundation for Cancer Research Duration: July 1, 2008 – June 30, 2009 PI: Hang (Hubert) Yin Total Amount Awarded: $10,000 Multidisciplinary Analyses of the Activation Mechanism of EBV-LMP-1 Agency: American Cancer Society (ACS) Award: ACS IRG (ACS-IRG-57-001-47) Duration: July 1, 2008 – June 30, 2009 PI: Hang (Hubert) Yin Total Amount Awarded: $20,000 Chemical Studies of TLR4-Mediated Glial Activation Agency: Council on Research and Creative Grant at the University of Colorado Award: Junior Faculty Development Award Duration: July 1, 2008 – June 30, 2009 PI: Hang (Hubert) Yin Total Amount Awarded: $5,000 ADMET Screening to Identify Novel Antagonists for the TLR4/MD-2 Complex Agency: Technology Transfer Office at the University of Colorado Award: Proof-of-Concept Grant (CU2099B) Duration: July 1, 2008 – February 28, 2009 PI: Hang (Hubert) Yin Total Amount Awarded: $5,000 Developing Novel Peptide Probes to Study the Latent Membrane Protein 1 Agency: Association for Research of Childhood Cancer Duration: June 1, 2008 – May 31, 2009 PI: Hang (Hubert) Yin Total Amount Awarded: $30,000 Exogenous Peptides as Novel Probes for Integrin Transmembrane Domains Agency: Council on Research and Creative Grant at the University of Colorado Award: Grant-in-Aid Duration: January 1, 2008 – December 31, 2008 PI: Hang (Hubert) Yin Total Amount Awarded: $7,000 Integrating Cutting-Edge Experimental and Computational Approach to Investigate Molecular Recognition within the Membrane Milieu

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Agency: International Union of Biochemistry and Molecular Biology Award: Wood-Whelan Research Fellowship PI: Hang (Hubert) Yin Total Amount Awarded: $3,000 Support a short period visit to Prof. Yechiel Shai’s lab at the Weizmann Institute of Science, Israel.

PRIMARY FACULTY SPONSOR OF STUDENT FELLOWSHIPS AACR Thomas J. Bardos Science Education Award for Undergraduate Students.

Agency: American Association for Cancer Research (AACR) Duration: January 1, 2012 – December 31, 2013 Award: Thomas J. Bardos Science Education Award for Undergraduate Students Awardee: Sara K. Coulup Total Amount Awarded: $4,288 NIH Ruth L. Kirschstein Pre-Doctoral Fellowship Agency: National Cancer Institute (NIH/NCI) Duration: January 1, 2012 – December 31, 2013 Award: NIH Ruth L. Kirschstein Pre-Doctoral Fellow (F31 CA165349) Awardee: Leslie A. Morton Total Amount Awarded: $96,918 National Science Foundation Diversity Promotion Award Agency: National Science Foundation (NSF) Duration: June 1, 2011 – May 31, 2012 Awardee: Leslie A. Morton Total Amount Awarded: $31,252 University of Colorado Molecular Biophysics Training Scholarship Agency: National Institute of General Medical Sciences (NIH/NIGMS) Duration: July 1, 2010 – June 30, 2012 Award: Pre-doctoral Training in Molecular Biophysics (T32 GM065103) PI: Joseph J. Falke Awardee: Isaac J. Godfroy Total Amount Awarded: $20,000 China Scholarship Council State Scholarship Agency: China Scholarship Council (CSC) Duration: October 1, 2009 – May 31, 2011 Award: Joint PhD Student Scholarship (2009619072) Awardee: Kui Cheng Total Amount Awarded: $18,900 China Scholarship Council State Scholarship Agency: China Scholarship Council (CSC)

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Duration: September 1, 2009 – August 31, 2014 Award: PhD Student Scholarship Awardee: Shuting Zhang Total Amount Awarded: $63,000 University of Colorado Signaling and Cellular Regulation Training Scholarship Agency: National Institute of General Medical Sciences (NIH/NIGMS) Duration: July 1, 2009 – June 30, 2011 Award: Training in Signaling and Cellular Regulation (T32 GM008759) PI: Natalie G. Ahn Awardee: Leslie A. Morton Total Amount Awarded: $53,157 University of Colorado Molecular Biophysics Training Scholarship Agency: National Institute of General Medical Sciences (NIH/NIGMS) Duration: July 1, 2008 – June 30, 2010 Award: Pre-doctoral Training in Molecular Biophysics (T32 GM065103) PI: Joseph J. Falke Awardee: Peter F. Slivka Total Amount Awarded: $43,600 Marrion Sharrah Organic Student Fellowship Duration: July 1, 2008 – August 31, 2008 Awardee: Peter F. Slivka Total Amount Awarded: $5,000 Design and Identify Highly Potent and Selective Fluorinated Peptide Probes to Target the Transmembrane Domains of Epstein-Barr virus Latent Membrane Protein 1 Agency: University of Colorado Cancer Center (UCCC) Duration: February 1, 2008 – January 31, 2009 Award: UCCC Junior Faculty/Post-Doc Fellowship Awardee: Ya Li Total Amount Awarded: $10,000 HHMI/NIH/UROP/BURST/Norlin Grants for Undergraduate Student Research (25) Agencies: University of Colorado Undergraduate Research Opportunities Program (UROP) Awardees: Madison M. Buchanan (2), Tina X. Zhao (3), Vy H. Le (2), Johnny Wong, Fraser W. Gaspar, Clyde T. Bagget, Anna R. Chase (2), Sampada Joshee, Alexander J. Martinko (2), Michael N. Pham (5), Alyssa A. Wiener, Mohammad H. Roostan (4), Sara K. Coulup (3) Total Amount Awarded: $51,500