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6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics Castellón (Spain) 20-22 June HAND PROGRAMME

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6th International Iberian Biophysics CongressX Iberoamerican Congress of Biophysics

Castellón (Spain) 20-22 June

–HAND PROGRAMME–

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6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics • 3

Wednesday, June 20thAUDITORIUM

Level -1

Workshop on NEW and NOTABLE BIOPHYSICSChairs: Nuno Santos and María García-Parajo

11:00-11:25Manuela Pereira (ITQB Univ. Nova Lisboa, P)Structural basis for energy transduction by respiratory alternative complex III

11:25-11:50Marco Manni (Institute Biofisika, Leioa ES)Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage

COFFEE BREAK

12:20-12:45Maria João Ramos (Univ. Porto, P)Advances and pitfalls in computational enzymatic catalysis

12:45-13:10

Laura Martínez-Muñoz (CNB-CSIC, Madrid ES)Separating actin-dependent chemokine receptor nanoclustering from dimerization indicates a key role for clustering in CXCR4 signaling and function

13:30-15:30 REGISTRATION / LUNCH BREAK

AUDITORIUM Opening Ceremony

15:30-16:00 Welcome

4 • 6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics

AUDITORIUMPlenary Opening LectureChair: Vicente Aguilella

16:00-16:45Sergey M. Bezrukov (NICHD-NIH, Bethesda MD, USA)Single-molecule biophysics: new insights into the dynamics of escape from potential and entropic traps

16:45-17:15 COFFEE BREAK (Poster and Exhibitor Hall)

AUDITORIUMS0 Symposium on PHYSICS IN BIOLOGYChairs: Antonio Alcaraz and Armindo Salvador

17:15-17:35David Reguera (Univ. Barcelona, ES)Physical virology: how physics can help us understand viruses

17:35-17:55Jorge Carneiro (Institute Gulbenkian, Oeiras, P)Time-lapse bioimage analysis solved as a cellular morphodynamics model fitting problem

17:55-18:15Fèlix Ritort (Univ. Barcelona, ES)Experimental measurement of information-content in nonequilibrium systems

18:15-18:25Horia Petrache (Indiana-Purdue Univ. IN, USA)Electrostatic charging of lipid membranes by ATP

18:25-18:35

Carmen Romero (Univ. Nacional Colombia, Bogotá)A comparative study between the limiting diffusion coefficients of α-amino acids and α,ω-amino acids in water and sodium chloride aqueous solutions at 298.15 K

18:35-18:45Daniel Sánchez de Alcázar (CICbiomaGUNE, Donostia, ES)Nanostructured films based on CTPR proteins

18:45-18:55Magdalena Kowacz (ITQB Univ. Nova Lisboa, P)Effect of infrared light on protein conformation, adhesion and enzymatic performance

6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics • 5

18:55-19:05Álvaro Martínez Monge (Univ. Barcelona, ES)Single-molecule characterization of heterogeneous DNA ensembles

19:05-19:15Carla Huerta-López (CNIC, Madrid, ES)Titin hydrogels to examine emergent mechanical properties of striated muscle

AUDITORIUMClarinet and piano concert (Sponsored by Small Biosystems Lab)

19:30-20:30

Antonio Amanti and Patrizia Marcatello

1. Clarinet Concerto No.1 in F minor transcribed to Piano by Carl Maria Von Weber

2. Sonata in B-Flat Clarinet and Piano by Francis Poulenc

3. Sholem-alekhem, Rov Feidman for Clarinet and Piano by Bela Kovacs

20:30-21:30 WELCOME RECEPTION

6 • 6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics

Thursday, June 21st

AUDITORIUM

S1 Symposium on PROTEIN STRUCTURE, DYNAMICS AND FUNCTIONChairs: Irene Díaz-Moreno and Paula Gameiro

9:00-9:25José María Delfino (Univ. Buenos Aires, ARG)Targeting the solvent accessible surface area (SASA) in proteins

9:25-9:35Mar Pérez Ruiz (CNB-CSIC, Madrid, ES)Study of T7 core proteins involved in DNA ejection: gp15 and gp16

9:35-9:50Lionel Rouzic (WYATT Technologies)The light scattering toolkit for characterization of proteins and other bio-macromolecules

9:50-10:00Ernesto Roman (Univ. Buenos Aires, ARG)Thermodynamics and protein dynamics relation in a psychrophile protein

10:00-10:10Ernesto Anoz-Carbonell (Univ. Zaragoza, ES)Regulation of FMN biosynthesis in homo sapiens: kinetics and thermodynamics of the riboflavin kinase activity

COFFEE BREAK (Poster and Exhibitor Hall)

10:40-11:05Adriana Rojas (CICbioGUNE, Derio, ES)Subversion of endosomal sorting machinery by legionella pneumophila

11:05-11:15Manuel Bano Polo (Univ. Valencia, ES)Transmembrane but not soluble helices fold far inside the ribosome tunnel

11:15-11:30Hanna Mueller-Landau (Dynamic Biosensors, GmbH)Titin hydrogels to examine emergent mechanical properties of striated muscle

6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics • 7

11:30-11:40

Enrique Marcos-Benteo (IRB Barcelona, ES)

De novo design of protein structures for binding small-molecules and nucleosomal DNA

11:40-11:50

Ivo Martins (Univ. Lisboa, P)

Zika virus capsid protein binds host lipid droplets via an auto-inhibitory mechanism

LECTURE HALL

Level 2

S2 Symposium on MEMBRANE STRUCTURE AND FUNCTION (Sponsored by Chemistry and Physics of Lipids, published by Elsevier)Chairs: Manuel Prieto and Jesús Salgado

9:00-9:25Senena Corbalán (Univ. Murcia, ES)C2 domain-containing proteins at the pre-synaptic space: rabphilin 3A as a paradigm.

9:25-9:40Bárbara Claro (Univ. Porto, P)Biophysical experiments and molecular dynamics simulation of self-assembling cyclic peptide nanotubes at biological model membranes

9:40-9:55Aurora Dolz (Delft Univ. NL)Free-standing membranes inside microfluidic devices and their use for the study of membrane nanotubes

9:55-10:10Esperanza Rivera-de-Torre (Univ. Complutense, Madrid, ES)Single cysteine mutants of actinoporins sticholysins I and II as tools for the study of membrane heteropores assembly

COFFEE BREAK (Poster and Exhibitor Hall)

10:40-11:05

Antônio José da Costa Filho (Univ São Paulo, BR), Sponsored by ISMARSubversion of endosomal sorting machinery by legionella pneumophila

11:05-11:20Tania Cunha Branco Santos (Univ. Lisboa, P)The impact of atypical sphingolipids on the biophysical properties of model and cell membranes

8 • 6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics

11:20-11:35José Lopes de Araújo (Univ. Porto, P)Siramesines anticancer activity: a biophysical approach

11:35-11:50Victor Levadny (Russian Acad. Sci. Moscow, RU)Modeling of initial stage of antimicrobial peptide magainin 2 pore formation in lipid vesicles

AUDITORIUMPlenary RSEF-SBE Lecture

Chair: Antonio Ferrer Montiel

12:00-12:45Jordi García-Ojalvo (Univ. Pompeu Fabra, Barcelona, ES)

Electrical signaling in bacteria

13:00-15:00 LUNCH BREAK

AUDITORIUM

S3 Symposium on CHANNELS, RECEPTORS AND TRANSPORTERSChairs: João Morais Cabral and Francisco Barros

15:00-15:25Cecilia Bouzat (INIBIBB, Bahía Blanca, ARG)Molecular function of α7 nicotinic receptors

15:25-15:50Juan Antonio Rosado (Univ. Extremadura, ES)Fine-tuning of store-operated Ca2+ entry by SARAF and EFHB

15:50-16:05Ekaterina M. Nestorovich (CUA, Washington DC, USA)Analysis of anthrax toxin channel current fluctuational dynamics

16:05-16:20

Javier Garcia Nafria (Medical Research Council, Cambridge, UK)Structures of GPCR-G protein complexes by volta phase plate electron cryo-microscopy

6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics • 9

COFFEE BREAK (Poster and Exhibitor Hall)

16:50-17:15Cristina Paulino (Univ. Gröningen, NL)Anion conduction and gating in the calcium-activated chloride-channel TMEM16A

17:15-17:30José Manuel González Ros (IBMC-UMH, Elche, ES)Modulation of the KcsA potassium channel by anionic phospholipids: role of the non-annular arginines

17:30-17:45Paula Giménez Mascarell (CICbioGUNE, Derio, ES)Structure of the CNMP domain of the magnesium transport mediator CNNM4.

17:45-18:00

María Lourdes Renart Pérez (Univ. Miguel Hernández, Elche, ES)Exploring potassium channels selectivity and inactivation through steady-state and time-resolved fluorescence spectroscopy

LECTURE HALL

S4 Symposium on CELLULAR BIOPHYSICSChairs: Teresa Giráldez and Graça Soveral

15:00-15:25

Ana Salomé Veiga (Univ. Lisboa, P)Unravelling the activity and mechanism of action of PEPR, a viral-derived membrane-active peptide, against staphylococcus aureus biofilms

15:25-15:50Sonia Contera (Oxford Univ., UK)Multiscale viscoelasticity of living systems

15:50-16:05Catarina Sousa Lopes (Univ. Lisboa, P)Changes on elasticity and morphology of erythrocytes from amyotrophic lateral sclerosis patients

16:05-16:20Fèlix Campelo (ICFO, Barcelona, ES)Biophysical mechanisms of collagen export from the endoplasmic reticulum

10 • 6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics

COFFEE BREAK (Poster and Exhibitor Hall)

16:50-17:15Ana Xavier Carvalho (Univ. Porto, P)Exploring myosins roles during cytokinesis

17:15-17:30Mariola Chacón-Rodríguez (Tech. Univ. Dresden, G)Meiotic nuclear oscillations are necessary to avoid excessive chromosome associations

17:30-17:45Mário R. Felício (Univ. Lisboa, P)Antimicrobial peptides PAMAP2 and PAMAP1.9 reveal anticancer activity

17:45-18:00Marta Gironella (Univ. Barcelona, ES)Relaxational kinetics in red blood cell mechanics: linking physical to biological aging

AUDITORIUMPlenary LAFeBS LectureChair: Juan Carmelo García

18:15-19:00Rosangela Itri (Univ. Sao Paulo, BR)Photo-oxidation in membrane and cell biophysics: combining fluorescence, X-ray scattering (SAXS) and microscopy techniques

19:00-20:00POSTER PARTY (Discussion of odd-numbered posters)

20:00-20:30SBE General Assembly and Election Assembly (AUDITORIUM)

6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics • 11

Friday, June 22nd

LECTURE HALL

S5 Symposium on NUCLEIC ACIDS AND SUPRAMOLECULAR COMPLEXESChairs: Eurico Cabrita and José López-Carrascosa

9:00-9:25Ana M. Melo (Univ. Lisboa, P)Exploring the conformational plasticity of tau-tubulin complex by single-molecule FRET: insights into function of a dysfunctional protein

9:25-9:50Pablo Chacón (IQFR-CSIC, Madrid, ES)Fitting tools for integrative structural biology

9:50-10:15Ana Luisa Carvalho (Univ. Nova Lisboa, P)Investigating the carbohydrate preferences of cellulolytic bacteria

10:15-10:30Maria I. Dauden (EMBL, Heidelberg, G)Molecular architecture of the elongator catalytic sub-complex and its tRNA interaction

10:30-10:45Borja Ibarra (IMDEA Nanociencia, Madrid, ES)Mechanism of SSB displacement by the human mitochondrial DNA polymerase during lagging strand synthesis

10:45-11:00Julene Madariaga (CNB-CSIC, Madrid, ES)Characterizing protein (un)binding rates at the single-molecule level using lateral magnetic tweezers combined with TIRF microscopy

AUDITORIUM

S6 Symposium on COMPUTATIONAL AND SYSTEM BIOPHYSICSChairs: Óscar Millet and Claudio Soares

9:00-9:20José García de la Torre (Univ. Murcia, ES)Prediction of solution properties of globular and partially disordered proteins and nucleic acids

9:20-9:40José M. Vilar (UPV-EHU, Bilbao, ES)Prediction and inference in complex biophysical systems

12 • 6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics

9:40-10:00Manuel Melo (Univ. Nova Lisboa, P)The light scattering toolkit for characterization of proteins and other bio-macromolecules

10:00-10:15Vicent Moliner (Univ. Jaume I, Castellón, ES)QM/MM theoretical studies of enzyme catalyzed reaction

10:15-10:30

Hugo Filipe (Univ. Coimbra, P)Quantitative assessment of methods often used to obtain rate constants from biomolecular simulations translocation of cholesterol across a lipid bilayer

10:30-10:45Gerardo Félix (UAM, Mexico DF)Influence of the intracellular calcium buffering properties on the secretory response of a human pancreatic beta-cell

10:45-11:00Sergio Martí (Univ. Jaume I, Castellón, ES)Computational study of the retro-aldol de novo designed enzymes

11:00-11:30 COFFEE BREAK (Poster and Exhibitor Hall)

AUDITORIUMPlenary LectureChair: José Miguel Mancheño

11:30-12:00Celerino Abad-Zapatero (Univ. Illinois, Chicago IL, USA)From altar boy to sorcerers apprentice: biophysics and beyond

12:00-13:00POSTER PARTY (Discussion of even-numbered posters)

13:00-15:00 LUNCH BREAK

6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics • 13

AUDITORIUMAWARDS SYMPOSIUMChairs: Jesús Pérez-Gil and Nuno Santos

15:00-15:15 INTRODUCTION

15:15-15:45F. Javier Luque (Univ. Barcelona, ES)Exploring the molecular determinants of ligand recognition and binding: from chemical structure to mechanisms of drug action

15:45-16:15Pere Roca-Cusachs (IBC, Barcelona, ES)Sensing matrix rigidity: transducing mechanical signals from integrins to the nucleus

16:15-16:45Marta Coimbra Marques (Univ. Lisboa, P)Thermodynamics and protein dynamics relation in a psychrophile protein

16:45-17:15Joan Camuñas (Stanford Univ., Stanford CA, USA)

From single molecule to single cell: the power of one

17:30-18:00 COFFEE BREAK (Poster and Exhibitor Hall)

AUDITORIUMPlenary Closing LectureChair: Félix Ritort

18:00-18:45Frederick C. Mackintosh (Rice Univ., Houston TX, USA)Phase transitions and the principle of detailed balance in living systems

19:00-19:30AWARDS AND CLOSING CEREMONY (AUDITORIUM)

14 • 6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics

20:30 Bus Departure from Hotel LUZ

21:00-23:00Congress Dinner in Benicassim (Club Palasiet Restaurant)

23:30 Bus Departure from Restaurant to Hotel LUZ

USEFUL INFORMATION

Universitat Jaume I (UJI) - Map

6th International Iberian Biophysics Congress X Iberoamerican Congress of Biophysics • 15

Location plans

Level O

Level 2

Level -1

Cafetería(Level -1)

Auditorium(Level -1)

Poster Hall(Level 0)

LectureHall

(Level 2)

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