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Yeongjoon Gil, Ph.D. Founder & CEO INNOVATION for HUMAN

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Yeongjoon Gil, Ph.D.Founder & CEO

INNOVATION for HUMAN

We are working to disrupt the healthcare industry

through wearable technology .

HUiNNO is a new innovative Blood Pressure Monitor that can be worn on your

wrist to instantaneously detect blood pressure, heart rate, ECG, and more

WHAT IS ONE OF THE MOST

IMPORTANT VITAL SIGN?

BLOOD PRESSURE

Hypertension (High BP) is a leading cause of stroke, heart attack, dementia, kidney failure, etc.

PROBLEM

406,351total death

(2007)

1death in every

1.3minute

If you can continuously be aware of

Blood Pressure to manage and

control hypertension,

you can significantly reduce risk of

life-threatening complications

[1] Jeffrey J. Goldberger, Michael E. Cain, Stefan H. Hohnloser, Alan H. Kadish, Bradley P. Knight, Michael S. Lauer, Barry J. Maron, Richard L. Page, Rod S. Passman, David Siscovick, William G. Stevenson, Douglas P. Zipes, “American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death”, Circulation 2008, pp. 1497-1518, 2009.

PROBLEM

Existing monitors cannot measure blood

pressure continuously and conveniently

BP Monitors are very difficult and inconvenient to use

PROBLEM

All current devices are

• PRESSURE & CUFF BASED

• VERY SLOW

• CAN’T USE CONTINUOUSLY

• UNCOMFORTABLE

• INACCURATE

Lots of things can mess up your blood pressure

PROBLEM

Cause BP can appear higher by[2,3]

A full bladder 10 – 15 mmHg

An unsupported back 5 – 10 mmHg

Unsupported feet 5 – 10 mmHg

Crossed legs 2 – 8 mmHg

Cuff over clothing 10 – 40 mmHg

Unsupported arm 10mmHg

A conversation or is talking 10 - 15 mmHg

[1] http://www.ama-assn.org/ama/pub/ama-wire/ama-wire/post/doctor-quickly-improved-patients-blood-pressure-readings[2] Pickering, et al. Circulation 2005[3] O’Brien, et al. Blood Press Mon. 2002

SOLUTION

CIRCLO

INSTANT BLOOD PRESSURE

HIGHLY ACCURATE

CONVENIENT

1-seconds to measure BP

Provide up to 94% accuracy viacombining biometrics (ECG + PTT + SpO2 )

No cuffs or pressures to measure continuous and accurate BP

CIRCLO by HUiNNO

50 subject clinic trial at Pusan National University hospital

Provide BP measurement up to

94% Accuracyvia combining biometrics ( ECG + PTT + SpO2 )

95%+ accuracy receives

Grade Afrom BHS (British Hypertension Society)

42%

70%

86%

68%

84%

94%

≤5mmHg ≤10mmHg ≤15mmHg

PTT PTT(t), SpO2(t), ECG(t)

Blood Pressure Calculation Algorithm(Patent in KR: 10-2013-0116158)

Highly accurate ( 94% )

COMPETITIONS

Cuff-free measurement of blood pressure using PTT[1]

Latest Researches On Wearable BPMs

Offline analysis comprised (1) the automatic extraction of PTT values from ECG and PPG signals, (2) the evaluation of the ST and MT device accuracy by comparison of estimated and reference BP values.

Through the calibration step, the parameters mS/mD and qS/qD of the systolic/diastolic linear models were estimated in each subject.

[1] Masè M, Mattei W, Cucino R, Faes L, Nollo G., “Feasibility of cuff-free measurement of systolic and diastolic arterial blood pressure.,” J Electrocardiol. 2011 Mar, Vol. 44, No. 2, pp 201-207

Cuff-free measurement of blood pressure using PTT

- MIT Media lab- Specification: Using PTT

- Inventors: Jae-Geol Cho, etc- Original Assignee: Samsung Electronics - Section: Human Necessities- Classification: Medical Or Veterinary Science; Hygiene- Specification: Method and apparatus for cufflessly and non-invasively measuring wrist blood pressure in association with communication device

Latest Researches On Wearable BPMs

HUiNNO vs Other Wearable BPMs

1) ECG - Electrocardiogram

2) SpO2 - Saturation of peripheral Oxygen

Developer Parameter Accurate Instant ContinuousBiofeedback

Platform

Visi Mobile Oscillation

Withings Oscillation

Bpro PPG

Samsung

Electronics PTT

MIT

PrototypePTT

OUR

DEVICEECG1) + PTT + SpO2

2)

Wearables Are Totally Failing [WIRED.com]

As of September 30, there were 266 wearable devices on the market [1]

[1] http://www.wired.com/2014/11/where-fitness-trackers-fail/

Smart Watches

Wearables Are Totally Failing [WIRED.com]

Wearable medical devices are currently a $2.8b market and will grow 25% p.a. by 2019 to $8.3b[1].

[1] http://mordorintelligence.com/product/global-wearable-market-growth-trends-and-forecasts-2014-2019/

$2.8 B2014

$8.3 B2019

Smart Watches

Wearable devices can’t measure Blood Pressure

Smart Watches

All of the wearable devices are focusing more on healthcare, but no device can measure the most vital sign:

BLOOD PRESSURE

MARKET

$1.2 Billionin 2015

103MillionHypertensive Patients

Blood Pressure monitoring market to

grow to 1.2 Billion USD in 2015

(HIS Media Group 2013)

32.5% of adults in the U.S.

over 20 suffer from hypertension

(M brain trend monitor 2014.02)

Blood Pressure Monitor + Smart Watch Market

MARKET

Increase in demand for blood pressure measurement in smart devices

DEVICE APP / SERVICE CLOUD PLATFORM

16580

CUSTOMERS HEALTHCARE

Business Model

June.2014Incorporation in US

Dec.2014Working Mock-up

July.2014

Incorporation in KR

Q1.2015

Clinic trial

Q2.2015FDA Process Begin

Q4.2015Launching

Q3.2015

Mass product

Milestone

HUiNNO. Inc.www.huinno.com

E-mail: [email protected]

INNOVATION for HUMAN