Course Overview This conference is intended to raise awareness about the signs and symptoms of Graft versus Host Disease (GvHD), review cutting edge approaches to prevention and treatment, and highlight and promote research to further our understanding of its cause. The symposium will have two tracks: a scientifically rigorous one for physicians and practitioners, and a survivor track that will focus on challenges faced by BMT recipients and their families. The survivor track is intended to provide both education and the opportunity for individuals to interact with national leaders in the GvHD field. The afternoon “Meet the Expert” uniquely interactive breakout sessions will provide an opportunity for the physicians, survivors and their families to come closely together during the program.

Learning ObjectivesAt the conclusion of this conference, participants will be prepared to:1. Describe current advances in the biology and treatment of acute GvHD 2. Describe novel targets and new agents in the treatment of chronic GvHD3. Outline novel strategies for the prevention of GvHD4. Discuss the role of B-cells in the pathogenesis of chronic GvHD5. Outline the oral complications of chronic GvHD and current treatment strategies6. Identify the unique perspectives and lessons learned from a physician patient with GvHD

Target AudienceThis program is intended for hematologists, medical oncologists, bone marrow transplant physicians, pharmacists, nurses, and patients and their families.

Location and AccommodationsUPMC Shadyside is located at 5230 Centre Ave, Pittsburgh, Pennsylvania.

Hotel rooms have been reserved at Courtyard Pittsburgh Shadyside (5308 Liberty Ave, Pittsburgh, Pennsylvania) at a rate of $155/night. Ask for the group block (GvHD Symposium-MAC Foundation) or code (MAC). Please reserve your room by April 13th to receive the discount.By phone: 412-683-3113 When reserving, please mention the Graft versus Host Disease Symposium. Online: www.marriott.com/hotels/travel/pitok-courtyard-pittsburgh-shadyside/ GRAFT vs. HOST DISEASE

NATIONAL SYMPOSIUMFRIDAY, MAY 13UPMC Shadyside5230 Centre Ave | Pittsburgh, Pennsylvania 2016

GRAFT vs. HOST DISEASE NATIONAL SYMPOSIUMFRIDAY, MAY 13UPMC Shadyside5230 Centre Ave | Pittsburgh, Pennsylvania20

16

CONTINUING MEDICAL EDUCATIONCONTINUING MEDICAL EDUCATION

Mer

edith

A. C

owde

n Fo

unda

tion

326

Inve

rnes

s Ro

adAk

ron,

Ohi

o 44

313

The commitment to exceptional patient care begins with revolutionary discovery.University Hospitals Case Medical Center is the primary affiliate of Case Western Reserve University School of Medicine, a national leader in medical research and education and consistently ranked among the top research medical schools in the country by U.S. News & World Report. Through their faculty appointments at the Case Western Reserve University School of Medicine physicians at UH Case Medical Center are advancing medical care through innovative research and discovery that brings the latest treatment options to patients.

Contact HoursPhysiciansThis activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Case Western Reserve University School of Medicine and the Meredith A. Cowden Foundation. Case Western Reserve University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Case Western Reserve University School of Medicine designates this live activity for a maximum of 5.5 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses The Ohio Board of Nursing will accept at face value the number of contact hours awarded for an educational activity that has been approved for CE by a nationally accredited system of CE approval.

GvHDPRESENTED BY:

JOINTLY SPONSORED BY: SUPPORTED BY:

Course Agenda2:15–2:55pm Concurrent Break Out Session 5:

Physicians: The Role of B-Cells in Chronic GvHD Stefanie Sarantopoulos, MD, PhD

Patients/Families: Gynecologic Complications in Chronic GvHD Pamela Stratton, MD

2:55–3:05pm Break

3:05–3:45pm Concurrent Break Out Session 6:

Physicians: Oral Chronic GvHD Jackie Mays, DDS

Patients/Families: Meet the Experts

3:45–4:00pm Break and Return to General Session

4:00–4:30pm Closing Comments

4:30–5:30pm Cocktail Reception

Registration GRAFT vs. HOST DISEASE First Name Last Name

Patient Guest Name

Degree(s)/ Credentials

Address

City State Zip

Institutional Affiliation Specialty

Email Phone Number

FeeRegistration fee includes all conference materials, food and continuing education credit. Full refunds will be made for cancellations on or prior to May 6 by 5/6 after 5/6

MD/PhD/Pharmacists $125 $150

Nurses/ Other Health Professionals $100 $125

Students/ Post Docs/ Fellows $25 $25

Patients and their Families FREE* FREE* * Patients and their families must pre-register.

RegistrationBy Mail: Wearn 154A Attn: Gillian Irwin 11100 Euclid Avenue Cleveland, OH 44106-5065

Method of PaymentEnclosed is my check # _________ made payable to Case Western Reserve University.

Charge my: ____Discover ____MasterCard ____Visa ____American ExpressCard Number_____________________________________ Security Code___________Expiration Date_________________Signature_________________________________

Planning CommitteeKenneth Cooke, MD Director, Pediatric Blood and Marrow Transplantation Program Herman and Walter Samuelson Professor of Oncology Professor, Oncology and PediatricsJohns Hopkins Sidney Kimmel Comprehensive Cancer Center

Gerald W. Cowden, JD Founder and President Meredith A. Cowden Foundation

Marti Cowden Vice President Board Member and Event Coordinator Meredith A. Cowden Foundation

Marcos de Lima, MD Professor, Medicine Case Western Reserve University Director, Hematologic Malignancies and Stem Cell Transplant Program Director, Bone Marrow Transplant University Hospitals Seidman Cancer Center

Stanton L. Gerson, MD Professor, Medicine Director, Case Comprehensive Cancer Center Case Western Reserve University Director, University Hospitals Seidman Cancer Center

Annie Im, MD Assistant Professor of Medicine, Division of Hematology/Oncology

University of Pittsburgh

Matt E. Kalaycio, MD, FACP Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Chair, Hematology and Medical Oncology Cleveland Clinic

Hien Duong Liu, MD Associate Staff, Hematologic Oncology and Blood DisordersCleveland Clinic

Steven Z. Pavletic, MD, MS Head, Graft-versus-Host and Autoimmunity Unit Experimental Transplantation and Immunology BranchNational Cancer Institute, National Institutes of Health

FacultyCourse Agenda

7:30–8:00am Registration/Continental Breakfast/Sponsor Exhibit Tables

8:00–8:15am Welcome by Host Committee Gerry Cowden, Founder, ~ Kenneth Cooke, MD ~ Marcos de Lima, MD Annie Im, MD ~ Matt Kalaycio, MD ~ Hien Liu, MD ~ Steve Pavletic, MD, MS

8:15–8:25am Physician Track Participants Move to Session Location

8:25–9:05am Concurrent Break Out Session 1:

Physicians: Update on Acute GvHD Ernst Holler, MD, PhD

Patients/Families: CAR-T Cell Therapy Catherine Bollard, MBChB, MD

9:10–9:50am Concurrent Break Out Session 2:

Physicians: Novel Targets in the Treatment of Chronic GvHD Annie Im, MD

Patients/Families: New Treatments in Chronic GvHD Mary Flowers, MD

9:50–10:05am Break

10:05–10:45am Concurrent Break Out Session 3:

Physicians: The Impact of Post-Transplant Cyclophosphamide on GvHD Leo Luznik, MD

Patients/Families: Understanding Clinical Trials: Why Are They Important and How Can I Enroll In One? Hien Liu, MD

10:50–11:30am Concurrent Break Out Session 4:

Physicians: Naïve T-Cell Depletion for Prevention of GvHD Warren Shlomchik, MD

Patients/Families: Quality of Life and GvHD Donna Posluszny, PhD

11:30–11:45am Break & Information/Sponsor Exhibit Tables

12:00–12:30pm Luncheon is Served

12:30–1:15pm Keynote Presentation: The Struggle to Survive the Cure: Insights from a Physician living with GvHD Lukas Wartman, MD

1:15–2:00pm Panel Discussion

2:00–2:15pm Break/Move to Session Locations

By Phone: 216.577.2280Online:http://cancer.case.edu/events/conferences/gvhd/registration/

Catherine Bollard, MBChB, MD Director, Program for Cell Enhancement and Technologies for ImmunotherapyDirector, Immunology Initiative - Sheikh Zayed Institute for Pediatric Surgical InnovationChildren’s National Health System

Amy Chmielewski, MSSA, MA, LSW Social Worker II, Malignant Hematology & Stem Cell TransplantUniversity Hospitals Seidman Cancer Center

Kenneth Cooke, MD Director, Pediatric Blood and Marrow Transplantation Program Herman and Walter Samuelson Professor of Oncology Professor, Oncology and PediatricsJohns Hopkins Sidney Kimmel Comprehensive Cancer Center

Marcos de Lima, MD Professor, Medicine Case Western Reserve University Director, Hematologic Malignancies and Stem Cell Transplant Program Director, Bone Marrow Transplant University Hospitals Seidman Cancer Center

Mary Evelyn D. Flowers, MD Director, Clinical Long-Term Follow-UpMember, Fred Hutchinson Cancer Research Center Professor, Medicine University of Washington

Ernst Holler, MD, PhD Professor, Department of Hematology and OncologyUniversity Medical Centre, University of Regensburg

Annie Im, MD Assistant Professor of Medicine, Division of Hematology/Oncology University of Pittsburgh

Matt E. Kalaycio, MD, FACP Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Chair, Hematology and Medical Oncology Cleveland Clinic

Hien Duong Liu, MD Associate Staff, Hematologic Oncology and Blood Disorders Cleveland Clinic

Leonido Luznik, MD Associate Professor, OncologyJohns Hopkins Sidney Kimmel Comprehensive Cancer Center

Jacqueline Mays, DDS Chief, Oral Immunobiology UnitAssistant Clinical InvestigatorNational Institute of Dental and Craniofacial Research, National Institutes of Health

Steven Z. Pavletic, MD, MS Head, Graft-versus-Host and Autoimmunity Unit, Experimental Transplantation and Immunology BranchNational Cancer Institute, National Institutes of Health

Donna M. Posluszny, PhD Assistant Professor, Medicine Associate Director of Training, Biobehavioral Oncology ProgramUniversity of Pittsburgh Cancer Institute

Stefanie Sarantopoulos, MD, PhD Cell Therapy and Hematologic Malignancies Specialist, Duke Adult Blood and Marrow Transplant ClinicDuke University

Warren D. Shlomchik, MD Director, Stem Cell Transplantation and Cell Therapies, Division of Hematology OncologyUniversity of Pittsburgh and University of Pittsburgh Cancer Institute

Pamela Stratton, MD Sr. Clinical Staff Specialist (CO) National Institutes of Health

Keynote SpeakerLukas D. Wartman, MD Assistant Professor , Department of Medicine, Oncology Division Stem Cell Biology Section Washington University Medical SchoolKeynote Address: The Struggle to Survive the Cure: Insights from a Physician living with GvHD

Speakers