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GUJARAT TECHNOLOGICAL UNIVERSITY

BIO-MEDICAL ENGINEERING (03)

BIOMATERIALS & IMPLANTS

SUBJECT CODE: 2150301

B.E. 5th SEMESTER Type of course: Core

Prerequisite: Human anatomy and physiology, mechanics of solids, structure of polymers, protein,

polysaccharides, metals and non metal elements, atomic bonding.

Rationale: The purpose of this course is to acquaint each student with the field of material Science

and the bio materials that are used in medical devices or in contact with biological systems. The

effectiveness of the technology depends on the behaviour of the Bio materials and the Medical

devices.

Teaching and Examination Scheme:

Teaching Scheme Credits Examination Marks Total

Marks L T P C Theory Marks Practical Marks

ESE

(E)

PA (M) ESE (V) PA

(I) PA ALA ESE OEP

4 0 2 6 70 20 10 20 10 20 100

Content:

Sr. No.

Content Total

Hrs

%

Weightag

e

1

BIOMATERIAL: INTRODUCTION, TYPES, PROPERTIES

Synthetic, Metals and non-metallic alloys, Ceramics, Inorganics and

glasses. Bio-resorbable and biologically derived materials, Bio-derived

macromolecules, Standard and assessments of biomaterials, Surface

properties of biomaterials and their testing.

5 5

2

POLYMERS:

Polymerization, Polyethylene, Clinical study of soft polymers, Bio-

erodible polymers, Blood compatible polymers, Bioactive polymers,

Hydrogels; Hard Methacrylats, Drug incorporation polymer gels,

Biocompatibility of polymers, blood compatibility improvement,

processing techniques for the polymers, assembling medical disposable.

5 10

3

METALS AND METALLIC ALLOYS:

Stainless steel, Titanium and Titanium alloys, Cobalt based alloy Nitinol,

Dental metals, Dental amalgam, Gold, Nickel, and Corrosion of the

metals.

14 20

4

CERAMICS AND COMPOSITE BIOMATERIALS:

Ceramics- Introduction to biomedical usage- bonding natural tissues,

Bio-active glass, High density alumina; Calcium phosphate ceramics-

Porous materials, Biological interactions, Dental ceramics- High strength

materials- Thermal expansions, Fracture toughness, Drug delivery from

ceramics, Wet chemical synthesis, Particulate and Fibrous composites,

Soft composites, Dental Composites, Saline, Coupling agents, Micro-

field materials, White-light systems bonding to teeth, Clinical trials,

synthesis of filters, Matrix resins, Mechanical and physical evaluation,

Nano-biomaterials: properties, preparation, characterization,

6 10

applications

5

BIOCOMPATIBILITY:

Methods for testing and evaluating biocompatibility: In Vitro Testing, In

Vivo Testing; Hemocompatibility, Osteocompatibility,

Odontocompatibility, Cytotoxicity Testing, Hypersensitivity/ Allergic

Responses, Genotoxicity, Tissue reaction to external materials,

Blood/biomaterial interaction, Corrosion and wear of biomaterials,

Treatment of materials for biocompatibility, Biodegradable materials and

their applications, Rheological properties of biological solids- bone,

tendons, blood vessels, biological liquids, mucus

10 20

6

RESPONSE OF BIOMATERIALS TO HUMAN BODY:

Biological effects of the implants on the human body: Inflammatory

response, coagulation and haemolysis, adaption, systematic distribution

and excretion, allergic foreign body response, chemical and foreign body

carcinogenesis

6 5

7

CARDIAC IMPLANTS:

Vascular grafts, Artificial Heart Valves, Synthetic Blood vessels, Inferior

Vena Cava Filters

OPTHALMIC IMPLANTS:

Contact lenses; Soft and hard lenses, Disposable lenses, Intra Occular

Lenses (IOLs), Viscoelastic solution, Vitreous Implants, Eye shields,

Drainage tubes in Glaucoma, Acrylic adhesives, Artificial Silicon

Retina, Bionic Eye

ORTHOPEDIC IMPLANTS:

Temporary fixation devices, Fracture healing, Repair of the ligaments,

ACL reconstruction using biological and synthetic materials, Joint

replacements: Total Hip replacement, Total knee replacement, Bone

regeneration with re-sorbable material

DENTAL IMPLANTS:

Dental implant modalities: Dentures, Subperiosteal, Endosteal; Blade

type, Root form, Packaging and preparation of dental implants, Bases

liners and varnishes for cavities, Impression materials

TISSUE GRAFTS AND SURGICAL AIDS:

Tissue grafts and rejection process, Prevention of rejection, Artificial

Skin, Artificial Blood, Breast Implants, Maxillofacial implants, Suture

Materials, Wound dressings, Tissue Adhesives and sealants, Burn

dressings, Catheters, Surgical Tapes

14 30

TOTAL HOURS 60 100%

Suggested Specification table with Marks (Theory):

Distribution of Theory Marks

R Level U Level A Level N Level E Level C Level

30% 30% 30% 5% 5% -

Legends: R: Remembrance; U: Understanding; A: Application, N: Analyze and E: Evaluate C: Create

and above Levels (Revised Bloom’s Taxonomy)

Note: This specification table shall be treated as a general guideline for students and teachers. The

actual distribution of marks in the question paper may vary slightly from above table.

Reference Books: 1. Biomaterials By Sujata V. Bhatt

2. Biomaterials Medial Devices and Tissue Engineering By Fredrick H. Silver Chapman and Hall

3. Biomaterials science and engineering By J. B. Park Plenum press, New York

4. Biomaterials Science- An introduction to materials in medicine By Buddy D. Ratner

5. Biomaterials- An introduction By Joon B. Park, Roderic S. Lakes

6. Biomedical Materials, R.Narayan(ed.), Springer Science.

Course Outcome:

After learning the course the students should be able to do:

1. To learn about biomaterials, classifications, their properties, performance specification and

biological applications.

2. To judge which material/implant should be used for what kind of application according to

nature of diseased and ill area of the body.

3. To decide the testing and selection procedure for specific biomaterial/implant.

4. To develop and design artificial models/materials with the help of software available in

market.

5. To compare different materials based on its strength, flexibility, inertness and its response to

biological tissues.

List of Experiments: (Outlines)

1. Introduction to Biomaterials.

2. To study about Metal as a Biomaterials.

3. To study about Polymers as a Biomaterial.

4. To Study about Composite as a Biomaterial.

5. To Study about Cardiovascular Implants.

6. To Study about Hip Prosthesis and Knee Prosthesis

7. To Study about Dental Implants.

8. To Study about Occular Implants.

9. Study of Factors Affecting Degradation of Biomaterials.

10. Study of Biological Interactions of Biomaterials.

11. Introduction to Biomaterial Testing.

12. To study about Biomedical implant design softwares.

Design based Problems (DP)/Open Ended Problem: To design different types of Artificial Heart

valve.

Major Equipment: Biomaterial/Implant Simulation Software

ACTIVE LEARNING ASSIGNMENTS: Preparation of power-point slides, which include videos,

animations, pictures, graphics for better understanding theory and practical work – The faculty will

allocate chapters/ parts of chapters to groups of students so that the entire syllabus to be covered. The

power-point slides should be put up on the web-site of the College/ Institute, along with the names of

the students of the group, the name of the faculty, Department and College on the first slide. The best

three works should submit to GTU.

1

Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V (NEW) - EXAMINATION – SUMMER 2017

Subject Code: 2150301 Date: 12/05/2017 Subject Name: Biomaterials & Implants Time: 02:30 PM to 05:00 PM Total Marks: 70 Instructions:

1. Attempt all questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks.

MARKS

Q.1 Short Questions 14

1 What is Biomaterial?

2 Which polymer is prefer for Drug delivery system?

(a) PMMA

(b) Hydrogel

(c) Polyesters (d) b & c

3 Which polymer is prefer for dental Implants?

(a) PMMA

(b) Hydrogel

(c) Polyesters

(d) poly hydroxyethyl methacrylate (PHEMA)

4 What is Bovine heterograft?

5 Define Radiopacity.

6 Give name of materials that are preferable for surgical wires and pins.

7 What is biological fixation?

8 What is shape memory effect?

9 Define Biocompatibility.

10 What is relatively bioinert ceramics? Give names of relatively

bioinert ceramics.

11 Enlist the used of Gold as Biomaterial.

12 Give the name of materials used for ligaments repairs.

13 Which materials used for collecting impression in dental

applications?

14 Give the name of materials used for Tissue adhesive.

Q.2 (a) Enlist materials used in THR (total Hip replacement) implant. 03

(b) Give properties of Nitinol and their medical applications. 04

(c) Give introductory note on Biological effects of the implants on the

human body. 07

OR

(c) Explain composition and mechanical properties of Cobalt based alloy

for medical applications. 07

Q.3 (a) What is the bionic eye? 03

(b) Write introductory note on dental applications of ceramics 04

(c) Explain important surface properties for desirable biocompatibility of

implants. 07

OR

Q.3 (a) Write a short note on Biological Grafts. 03

(b) Explain metallic corrosion process with necessary schematic. 04

2

(c) What is surface reactive ceramics? Explain temperature-time cycle

for a glass ceramic. 07

Q.4 (a) Define/explain meaning of following terms.

Xenografts

carcinogenesis

03

(b) Write a short note on nano-biomaterials and their applications. 04

(c) Explain role of ceramics for Drug delivery applications. 07 OR

Q.4 (a) Define/explain meaning of following terms.

Genotoxicity

Hypersensitivity

03

(b) Explain methods for testing and evaluating biocompatibility. 04

(c) Write a short note on biodegradable materials and their applications. 07

Q.5 (a) Write a short note on sutures materials. 03

(b) Explain role of re-sorbable material in bone regeneration. 04

(c) Explain the process of polymerization. Enlist and describe the

characteristics of bio-erodible polymers. 07

OR

Q.5 (a) Give details about materials used for maxillofacial implants. 03

(b) Give structural & material composition details of Intra ocular lenses

(IOLs). 04

(c) Explain engineering aspects of artificial heart valves. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V(New) • EXAMINATION – WINTER 2016

Subject Code:2150301 Date:24/11/2016

Subject Name:Biomaterials & Implants

Time: 10:30 AM to 01:00 PM Total Marks: 70 Instructions:

1. Attempt all questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 Short Questions 14

1 Define Implants.

2 Name biodegradable ceramics.

3 What is biocompatibility?

4 Explain osseointegration.

5 Define vascular grafts.

6 Which biomaterial is used for synthetic blood vessels?

7 What are thermosets.

8 What type of material is used in bone plate?

9 Name reabsorbable ceramics.

10 What do you understand by shape memory property?

11 Give difference between autograft and allograft.

12 Which biomaterial is used in maxillofacial implant?

13 Give application of tissue Adhesive.

14 Name prosthetic heart valves.

Q.2 (a) State mechanical properties of stainless steel. 03

(b) Explain in short Dental Amalgam. 04

(c) Explain corrosion of metals illustrating electrochemical reaction. 07

OR

(c) Which is surface reactive ceramics? Explain its structure and its application. 07

Q.3 (a) Explain the three distinct phases of coagulation. 03

(b) Short note on Zirconia. 04

(c) Explain surface properties of biomaterial. 07

OR

Q.3 (a) What is nanomaterial? 03

(b) Explain how ceramics are used for drug delivery. 04

(c) Explain the effect of blood material interaction. 07

Q.4 (a) Enlist types of contact lenses. 03

(b) Explain polymerization process. 04

(c) List the methods for biomaterial testing and explain it. 07

OR

Q.4 (a) Give application of PMMA. 03

(b) Enlist the factors responsible for orthopedic implant failure. 04

(c) Explain intraocular lens implant with schematic diagram. 07

Q.5 (a) Explain difference between bioinert and bioactive biomaterials. 03

(b) Explain hydrogel. 04

(c) Explain all the components of total hip replacement. 07

OR

Q.5 (a) Give application of composite. 03

(b) Explain cellular activity of bone healing. 04

(c) Explain types of cardiovascular implants. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V (NEW) - EXAMINATION – SUMMER 2016

Subject Code:2150301 Date:21/05/2016 Subject Name:Biomaterials & Implants Time:02:30 PM to 05:00 PM Total Marks: 70 Instructions:


Q.1 (a) Define below given terminologies:

1. Shape memory effect 5. Chemogradient surface

2. Xenografts 6. Galvanic corrosion

3. Steric hindrance 7. Plasticizer

4. Wolff ’s law

07

(b) Describe the surface properties of biomaterials. 07

Q.2 (a) Explain the process of polymerization. Enlist and describe the characteristics of

bio-erodible polymers.

07

(b) Write a short note on Bio-active glass. 07

OR

(b) Describe Hard-Tissue Replacement technique for manufacturing bioceramic

materials.

07

Q.3 (a) What is stress corrosion cracking? Explain electrochemical aspects of corrosion

of metallic implants.

07

(b) Enlist and explain any three Blood compatible polymers. 07

OR

Q.3 (a) Describe the manufacturing process of Stainless Steel & CoCr Alloy based

metallic implants.

07

(b) Explain physical and chemical surface modification methods to improve

biocompatibility for polymeric biomaterials.

07

Q.4 (a) Enlist and explain Titanium based alloys and their applications. 07

(b) Explain various techniques of biomaterial testing. 07

OR

Q.4 (a) Explain various artificial heart valves with necessary diagrams. 07

(b) Describe the functions and characteristics of artificial blood. 07

Q.5 (a) Write a brief note on intra Ocular Lenses. 07

(b) Explain the allergic foreign body response of biomaterials to human body. 07

OR

Q.5 (a) Write a brief note on Bionic Eye and its’ applications. 07

(b) Explain the process of total hip replacement surgery. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE – SEMESTER – V (NEW) EXAMINATION – WINTER 2015

Subject Code: 2150301 Date:03/12/ 2015

Subject Name: Biomaterials & Implants

Time: 10:30am to 1:00pm Total Marks: 70 Instructions:




Q.1 (a) Define following terms in detail: Biomaterial, Biocompatibility, Biological

material, Bioresorbable material.

07

(b) Explain various applications of Biomaterials with examples. 07

Q.2 (a) Explain Vascular grafts & Artificial heart valve as a Cardiac implant. 07

(b) The probability of failure of a knee replacement in the first year are 5% for

infection, 3% for wear, 2% for loosening, 1% for surgical complication & 4%

for fracture. Calculate the reliability of implant. Suppose in addition, 10% of the

patients complain of excessive pain; again calculate the reliability.

07

OR

(b) Write a short note on Stainless steel. 07

Q.3 (a) Explain types of Polymerization reaction. 07

(b) Enlist the types of cobalt based alloys. Explain the lost wax method for

manufacturing of implants using Co-based alloys.

07

OR

Q.3 (a) Write a short note on PMMA & PHEMA. 07

(b) Explain different types of Dental metals with properties & applications. 07

Q.4 (a) Explain Glass ceramic as a Biomaterial. 07

(b) Briefly explain applications of Composite Biomaterials. 07 OR

Q.4 (a) Write a short note on Calcium phosphate as a Ceramic biomaterial. 07

(b) Explain Corrosion & Wear of biomaterials. 07

Q.5 (a) Explain Biodegradable materials with their applications. 07

(b) Explain Contact lenses & IOLs. 07

OR

Q.5 (a) Explain different Biological effects of the implants on the human body. 07

(b) Explain Total Hip and Knee replacement in detail. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V (OLD) - EXAMINATION – SUMMER 2017


1. Attempt all questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks

Q.1 (a) Classify different types of materials which are used as biomaterials on the basis

of its applications, properties, advantages & disadvantages.

07

(b) Write a short note on Standards & Assessments of Bio-Materials. 07

Q.2 (a) Write a short note on corrosion of metallic implants. 07

(b) Define polymerization? Explain condensation polymerization. 07

OR

(b) Explain various tissue adhesives with their material composition 07

Q.3 (a) Give details of polymers used in Drug delivery system. 07

(b) Define Composites. Write a short note on Carbons Composites. 07

OR

Q.3 (a) Explain process of Biomaterial’s Biocompatibility testing. 07

(b) Give compositions and mechanical properties of 316L Stainless Steel with their

applications in Biomedical field.

07

Q.4 (a) Explain any application of Biomaterials in Ophthalmic field. 07

(b) Write a short note on Relatively Bioinert Bioceramics. 07

OR

Q.4 (a) Write a short note on Biodegradable materials & their applications. 07

(b) Give brief note on rehabilitation devices used for physiological functions of

human body systems- improvement or replacement and their material selection.

07

Q.5 (a) Explain designing aspects of Artificial Heart Valves with material selection. 07

(b) Write a short note on Material Selection Criteria and Preclinical Testing. 07

OR

Q.5 (a) Explain properties of biomaterials used in dental implants. 07

(b) Write short Note on Cellular response to implants. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V- EXAMINATION – SUMMER 2016



Q.1 (a) Enlist commonly used Biomaterials and its applications. 07

(b) Define following terms: 1) Prosthesis 2) Orthosis 3) Homografts 4) Xenografts 5) Autografts 6) Biological material 7) Shape memory effect.

07

Q.2 (a) Short Note: PMMA 07 (b) Explain polymerization in detail. 07

OR (b) Explain tissue interaction and response of Biomaterials. 07

Q.3 (a) Explain any two of the biomaterials used in dental implants in details. 07 (b) 1. Explain disadvantages of using metals in biomedical applications.

2. Explain thermal property of biomaterial. 07

OR Q.3 (a) Explain polymers as a drug delivery biomaterial in detail. 07

(b) Why is calcium phosphate ceramics used widely in bone applications? 07

Q.4 (a) Describe characteristics of hydrogel and its applications 07 (b) Write a short note on pacemaker. 07

OR Q.4 (a) Give properties of nitinol and applications in details. 07

(b) Give the short note on stainless steels. 07

Q.5 (a) Describe anatomy of hip joint and explain reason for failure of hip joint. 07 (b) Describe the biomaterial testing procedure in detail. 07

OR Q.5 (a) Explain surface properties of biomaterials & their testing. 07

(b) Write a short note on IOLs & Contact lenses. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V EXAMINATION – WINTER 2015

Subject Code: 150301 Date:05/12/2015


Time: 10:30am to 1:00pm Total Marks: 70 Instructions:




Q.1 (a) Write a short note on bioresorbable & biologically derived materials. 07

(b) Explain material selection criteria for biomaterial. 07

Q.2 (a) Define following terms:

1) biocompatibility 2) biomaterial 3) filler 4) prosthesis 5) orthosis 6) biological

material 7) shape memory effect

07

(b) What is polymerization? Explain condensation and addition polymerization. 07

OR

(b) Classify different types of materials which are used as biomaterials on the basis of its

applications, properties, advantages & disadvantages.

07

Q.3 (a) Explain roll biomaterials to drug delivery system. 07

(b) Explain properties and applications of nitinol. 07

OR

Q.3 (a) Describe structure and manufacturing process of Ti based alloys. 07

(b) Explain corrosion of metallic implants in detail. 07

Q.4 (a) Write a short note on intraocular lens and contact lens. 07

(b) Explain properties and composition of artificial long bones and Joints. 07

OR

Q.4 (a) Explain relatively bioinert ceramics and also give their uses. 07

(b) Explain tissue reaction to external materials and blood/biomaterial Interaction. 07

Q.5 (a) Explain any two artificial heart valves. 07

(b) Describe different type of biomaterials used in dental implants. 07

OR

Q.5 (a) Write a short note on biomaterial surface properties. 07

(b) Give brief note on rehabilitation devices used for physiological functions of human

body systems- improvement or replacement.

07

*************

Seat No.: _____ Enrolment No.______

GUJARAT TECHNOLOGICAL UNIVERSITY BE SEMESTER-V EXAMINATION-SUMMER-2015

Subject code: 150301 Date: 07/05/2015 Subject Name: Biomaterials & Implants Time: 02.30pm-05.00pm Total marks: 70

Instructions: 1. Attempt all questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks.

Q.1 (a) Define following terms:

1) Biocompatibility 2) Biomaterial 3) Implant 4) Prosthesis 5) Orthosis 6) Biological Material 7) Autografts

07

(b) Explain tissue response to implants. 07

Q.2 (a) Write a short note on Ti-Ni Aloys. 07 (b) Classify different types of materials which are used as biomaterials on

the basis of its applications, properties, advantages & disadvantages. 07

OR (b) Explain surface properties of biomaterials & their testing. 07

Q.3 (a) Enlist material selection criteria for biomaterial & explain it in detail. 07 (b) Write a short note on biomaterial hydrogels 07 OR

Q.3 (a) Write a short note on stainless steel. 07 (b) Explain biocompatibility of synthetic vascular implant material 07

Q.4 (a) Explain corrosion of metallic implants. 07 (b) What is biodegradable ceramics? Explain any one in detail. 07 OR

Q.4 (a) Describe different type of biomaterials used in dental implants. 07 (b) What is polymerization? Explain condensation and

addition polymerization. 07

Q.5 (a) Describe glass ceramics with formation & properties of it. 07

(b) What is shape memory effect? Explain properties and applications of NITINOL.

07

OR Q.5 (a) Write a short note on Mechanical Heart valves prostheses. 07

(b) Write a short note on PMMA. 07

***************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V • EXAMINATION – WINTER • 2014

Subject Code: 150301 Date: 01-12-2014

Subject Name: Biomaterials and Implants

Time: 10.30 am - 01.00 pm Total Marks: 70 Instructions:




Q.1 (a) Explain various tissue adhesives with their material composition. 07

(b) Write a short note on Bioresorbable & Biologically Derived Materials. 07

Q.2 (a) Define polymerization. Explain process of polymerization. 07

(b) Explain role of polymer in dental applications. 07

OR

(b) Explain role of polymers in Drug delivery system. 07

Q.3 (a) Write a short note on Ti and Ti-based alloy as a biomaterial. 07

(b) Explain bioactive glass with their temperature time cycle. 07

OR

Q.3 (a) Give brief idea about Biocompatibility testing of Biomaterials. 07

(b) Explain Various Materials used in component of total hip replacement. 07

Q.4 (a) Explain Interaction of Metallic Biomaterials with the Human Body

Environment.

07

(b) Give compositions and mechanical properties of 316L Stainless Steel. 07

OR

Q.4 (a) Write a short note on biodegradable polymeric biomaterials. 07

(b) Write a short note on Biomaterial Surface Properties. 07

Q.5 (a) Explain chemical process Corrosion of Metallic Implants. 07

(b) Explain structure and functioning of any two mechanical heart valve with

necessary schematic.

07

OR

Q.5 (a) Write a short note on Relatively Bioinert Bioceramics. 07

(b) Role of Biomaterials in Ophthalmic field of biomedical. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V • EXAMINATION – SUMMER • 2014


Subject Name: Biomaterials and Implants





Q.1 (a) What is Biocompatibility? Discuss different failure factors associated with Implants.

and determine the equation to check the reliability of Implants. 07

(b) Short Note: NITINOL 07

Q.2 (a) Enlist Different types of Metallic body implants and explain Properties and

Manufacturing Process of SS based Implants. 07

(b) Explain Endosseous Tooth Implants in Detail. 07

OR

(b) Short Note: Glass Ceramics 07

Q.3 (a) Enlist different types of polymeric Implants. Write a short note on Polyethylene with

its necessary Polymerization process. 07

(b) Short Note: Intraocular Lenses 07

OR

Q.3 (a) Short Note: Hydrogels 07

(b) Describe Design consideration of Artificial Heart Valves. 07

Q.4 (a) Describe Fibrous and Particulate composites used in Orthopedic Implants. 07

(b) Short Note: Hip Joints 07

OR

Q.4 (a) Draw the block diagram of synchronous and asynchronous pacemaker and also

Explain components used in pacemaker. 07

(b) Explain Corrosion of Metallic Implants in detail. 07

Q.5 (a) Discuss different Mechanical properties of Biomaterials and Implants 07

(b) Short Note: Bone Cement 07

OR

Q.5 (a) Give short Note on Cellular response to implants 07

(b) Describe structure and manufacturing process of TI based alloys. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V • EXAMINATION – WINTER 2013







Q.1 (a) What is polymerization? Explain condensation and addition

polymerization.

07

(b) Give Biomedical Applications of Polymeric Biomaterials 07

Q.2 (a) What is shape memory effect? Explain properties and applications of

NITINOL.

07

(b) Describe different type of biomaterials used in dental implants. 07

OR

(b) Explain the composites of stainless steel. 07

Q.3 (a) Explain Electrochemical aspects of Metallic Implants. 07

(b) Give material selection criteria for Biomaterials. 07

OR

Q.3 (a) Explain Relatively Bioinert Ceramics and also give their uses. 07

(b) Explain Drug Incorporation Polymer Gels. 07

Q.4 (a) Describe glass ceramics with formation & properties of it. 07

(b) Write a short note on PMMA. 07

OR

Q.4 (a) Write a short note on Titanium & Titanium Alloys for Bio-Implants. 07

(b) Explain Tissue Reaction to External Materials and Blood/Biomaterial

Interaction.

07

Q.5 (a) Explain structure and composition of long bone. 07

(b) Write a short note on Tissue Adhesives. 07

OR

Q.5 (a) Write a short note on Mechanical Heart valves prostheses. 07

(b) Write a short note on Biodegradable materials & their applications. 07

*************

1


GUJARAT TECHNOLOGICAL UNIVERSITY BE - SEMESTER–V • EXAMINATION – SUMMER 2013

Subject Code: 150301 Date: 20-05-2013 Subject Name: Biomaterials and Implants Time: 10.30 am - 01.00 pm Total Marks: 70 Instructions:


Q.1 (a) Explain Surface Modifications for Improving Biocompatibility. 07 (b) Give Biomedical Applications of Polymeric Biomaterials 07

Q.2 (a) Explain properties of stainless steel alloys for Bio-Implants. 07 (b) Write a brief note on filling and restorative materials used for Dental

application. 07

OR (b) Write a short note on Titanium and Titanium Alloys for Bio-Implants. 07

Q.3 (a) Explain Electrochemical aspects of Metallic Implants. 07 (b) Write a short note on Calcium Phosphate Ceramics-Porous Materials and

give their Medical Uses. 07

OR Q.3 (a) Explain Relatively Bioinert Ceramics and also give their uses. 07

(b) Explain Drug Incorporation Polymer Gels. 07

Q.4 (a) Give the applications of Surface reactive ceramics and Explain formation of glass ceramics.

08

(b) Write a short note on PMMA. 06 OR

Q.4 (a) Explain Importance of composite materials in Biomedical field. 06 (b) Explain Tissue Reaction to External Materials and Blood/Biomaterial

Interaction. 08

Q.5 (a) Write a short note on Intraocular Lens and contact lens. 07

(b) Write a short note on Tissue Adhesives. 07 OR

Q.5 (a) Write a short note on Mechanical Heart valves prostheses. 07 (b) Explain Material Selection Criteria and Preclinical Testing. 07

*************

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