Controlled Environment Laboratory and Pharmaceutical Equipment Solutions for Life Science, Pharmaceutical, Biomedical and Industrial Research Applications

Worldwide Edition, 2012/2013

Guide to Esco Products and Services

Esco Product Guide

Guide to Esco Products and Services

Table of Contents:

Corporate Profile ......................................................................... 2

Biological Safety Cabinets ........................................................... 6

Compounding Pharmacy Equipment ......................................... 7

Containment / Pharma Products ................................................. 8

CO2 Incubators ............................................................................. 9

Ductless Fume Hoods ................................................................. 10

In Vitro Fertilization Equipment ............................................... 11

Lab Animal Research Products .................................................. 12

Laboratory Fume Hoods ............................................................ 13

Laboratory Ovens and Incubators ............................................ 14

Laminar Flow Clean Benches .................................................... 15

PCR Products .............................................................................. 16

Ultralow Temperature Freezers ................................................ 17

After Sales Services .................................................................... 18

1

• A leader in the development of controlled environment,

laboratory and pharmaceutical equipment solutions.

• A world leader in biological safety cabinets.

• Headquartered in Singapore.

• North American facil it ies in Pennsylvania; sales,

service, logistics for US & Canada.

• Other Esco locations in Bahrain, China, India, Japan, Korea,

Malaysia, Philippines, UK, Vietnam.

• Group total of more than 600 employees.

• Distributors in more than 100 countries.

• Products independently tested to international standards.

• Large R&D investments, world leading technologies.

• State-of-the-art production, vertically integrated

manufacturing floor space.

• Worldwide service.

Welcome to Esco

Pictured: Esco Micro Pte. Ltd. is headquartered in Singapore, a modern city state located in Southeast Asia with a population of more than 4 million. From Singapore, Esco manages operations throughout the world.

Esco’s Vision is to provide enabling technologies for scientific discoveries to make human lives healthier and safer.

Pictured: Esco's state-of-the-art manufacturing space

2

Esco Product Guide

1988

1998

2001

2006

2008

3

Esco is founded in Singapore and begins to pio-neer cleanroom technology in Southeast Asia.

Esco manufactures first laminar flow clean bench-es; designs and builds first microelectronics Class 10,000 cleanroom for Siemens Corporation.

19781980

19811984

1990

2000

2010

2005

2007

2009

2011

Esco exports first products to points in Southeast Asia.

Esco incorporates Malaysian subsidiary.Esco designs and builds Class 100 laundry and be-comes first company in region to enter cleanroom

laundry business.

Esco establishes Esco Technology Center in Singapore.

Esco opens representative offices in Beijing, Shanghai and Guang-

zhou China.

Esco expands distribution to pharmaceutical, life sci-ence, biotechnology and medical research markets.

Esco expands presence in Chinese market

Esco establishes full-function manufacturing, testing and logistics distribution facility in Bintan Industrial Estate

Esco formally brings key biological safety and laminar flow products into compliance with European, NSF

and Japanese standards for containment and perfor-mance.

Esco becomes first Asian manufacturer to earn EN 12469 certification for biological safety cabinets.

The Chinese Food and Drug Administration invites Esco to participate in a joint committee to develop the

National Standard for Biological Safety Cabinets.

Esco launches global marketing program: World Class. Worldwide.

Esco establishes technical center in Shanghai to ex-pand R&D capabilities and product reach.

Infinity® – the world’s first biological safety cabinets designed with a redun-

dant dual fan system that guarantees operator protection even in case of a single fan failure.port expansion and

international reach.

Esco establishes Esco Tech-nologies, Inc. to open markets in the United States, Canada and Mexico.

Esco establishes Esco GB as sales and marketing subsidiary in the United Kingdom.

Esco establishes multiple offices in Europe, the Middle East, South Africa and India to support expansion and international reach.

Accuflow G2 - the world's first voltage and tempera-ture compensating speed control, specifically de-signed to virtually eliminate airflow fluctuatons.

Isotherm® - new Laboratory Ovens and Incubators from Esco.

Pharmacon(TM) - new Downflow Booths from Esco.

Isoclean® - new compounding pharmacy isolators from Esco.

Frontier Acela® - the world's first ergonomically designed, angled front, high performance low flow fume hood.

Labculture® Class II (Low Noise Series) – intro-duced the industry's lowest noise (~50dBA per EN) biological safety cabinets.

Esco launches CelCulture® - CO2 incubator with Sup-pressed O2 feature

Esco launches CelCulture® - new CO2 incubator

A Tradition of Quality

Esco becomes first Singapore company to earn on-site UL accreditation.

Swift® MaxPro and MiniPro - new generation PCR thermal cyclers from Esco.

2012 Esco launches Lexicon® range of Ultra-low - Temperature Freezers

4

Global Network

Products and Application

Laboratory Equipment

Biosafety and Laminar Flow

•ClassIITypeA2Biological Safety

Cabinets

•ClassIITypeB2Biological Safety

Cabinets

•ClassIIIBiologicalSafety Cabinets

•HorizontalLaminarFlow Clean Benches

•InVitroFertilizationWorkstations

•LaboratoryAnimal Research

Workstations

•PCRCabinets

•VerticalLaminarFlow Clean Benches

Esco Life Science Tools

Fume Hoods

•DuctlessFumeHoods

•ExhaustBlowers

•FumeHoodAirflow Monitors

•FumeScrubbers

•LaboratoryFumeHoods

Incubators and Ovens

•CO2 Incubators

•ForcedConvectionLaboratory Incubators

•ForcedConvectionLaboratory Ovens

•LowTemperatureBOD Incubators

•NaturalConvectionLaboratory Incubators

•RemoteMonitoring, Data

Logging, and Programming

Software

PCR

•PCRThermalCyclers

Not Available in North America

Pharmaceutical Equipment

Containment / Compounding

Pharmacy

•AirShowers

•GarmentStorageCabinets

•PassBoxes

•SoftCapsule

•StraddleUnits

•TransferHatches

•CytotoxicSafetyCabinets

•DownflowBooths

•PharmacyIsolators

•PowderWeighingBalance Enclosures

Cold Storage

•UltraLowTemperature

Freezers

Esco Product Guide

5

An integral part of our business plan-ning effort is based on managing a robust research and development pro-gram in Singapore, Shanghai and the USA, balanced against an investment in service support, training and cus-tomer education. Compared to indus-try averages, Esco invests a significant percentage of annual revenues in research and development. As a result of our investment, and with continuous

feedback and idea evaluation among our

research, global sales, marketing, pur-

chasing and manufacturing teams; Esco

products reflect the best contemporary

designs in performance, ergonomics and

customer satisfaction.

• 70 engineers located in technology

centers in Singapore, China, Indonesia

and USA

•Growing patent portfolio

•Core competencies:

- Embedded system, sensor and soft-

ware development and integration

- Containment engineering for bio-

hazards, chemical vapors and haz-

ardous powders

- Temperature, humidity, gas and en-

vironmental control

- Computational fluid dynamics

- And many more

Continuous Research and Development

Product Development and Innovation

Esco's manufacturing advantage stems from our extensive degree of vertical integration, enabled by our world-leading throughput. All processes, with few exceptions, are performed in-house. This allows us to achieve quality and reliability that is truly world-class. Our plant capabilities include:

• Incoming materials inspection and warehousing

•CNC-controlled sheet metal fabrication and welding

• Environmentally-friendly powder coating lines

• Electromechanical final product

assembly• Electrical / electronics sub-assembly•Multi-step electrical and physical

performance testing• Independent quality control at each

step in the production cycle•Microbiology, chemistry, containment

test labs

Esco's focus on quality and timeliness is relentless. Continuous improvement is a mantra. Cross functional teams from Esco Production, R&D, Quality Assurance, Senior Management, are regularly assembled to review and implement areas for improvement.

Quality, Cost, Productivity, Effectiveness, Timeliness

Manufacturing

Esco Biological Safety Cabinets represent more than 20 locally, regionally and internationally-recognized certifications. These accreditations testify to the enhanced performance of Esco products in biological and microbiological applications.

Esco is a world leader in biological

safety cabinets, offering the industry's

widest product range, with thousands

of installations in leading laboratories

in more than 100 countries around

the globe. Esco's biological safety

cabinets have earned more independent

certifications, in more countries, in more

languages, than any other product,

demonstrating our commitment to the

industry's best safety and quality.

Features:

•ULPA f i l t e r s w i th >99 .999%

efficiency for particle size between

0.1 to 0.3 microns.

• Low noise level.

• Energy savings.

• Ergonomic design.

Product lines:

•Class II, Type A2 Biological Safety

Cabinets.

•Class II, Type B2 Biological Safety

Cabinets.

•Class III Biological Safety Cabinets.

• Formalin Vaporizers.

•Options and Accessories.

Pictured: Biological Safety Cabinets

6The World's Most Certified Cabinets

Biological Safety Cabinets

Esco Product Guide

7

Esco compounding pharmacy equipment includes a complete range of barrier isolators, NSF listed biological safety cabinets and clean benches.

Esco Compounding Pharmacy Equipment

provides a safe and clean environment for

compounding of sterile drug preparations

and IV admixtures in compliance with

USP 797 criteria. Depending on the

nature of compounds being processed,

Esco Compounding Pharmacy Equipment

can be selected for any of two work zone

relative pressure options, all of which

feature vertical laminar airflow across the

work surface to assure ISO Class 3 level

cleanliness within the work area.

Only Esco offers:

•ULPA filters tested to a typical efficiency

of >99.999% for 0.1 to 0.3 micron

particles. ULPA filters last as long as

conventional HEPA filters and have

similar replacement costs.

• ISOCIDE™ antimicrobial coating on

all powder coated surfaces eliminates

99.9% of surface bacteria within 24

hours of exposure.

• Barrier isolators and biological safety

cabinets utilize stainless steel interiors

with coved corners.

• Barrier isolators feature built-in digital

airflow and pressure displays.

Product lines:

•Cytotoxic Safety Cabinets.

•Compounding Aseptic Isolators.

•Compounding Aseptic Containment

Isolators (Recirculating).

Pictured: Compounding Pharmacy Equipment

The Premium Solution for Sterile Drug Compounding

Compounding Pharmacy Equipment

Esco offers a complete range of solutions designed for pharmaceutical processing in both the containment and aseptic processing fields.

Pharmaceutical dispensing, sampling and

charging operations are now safer and more

efficient with the Esco range of Pharmacon™

Downflow Booths. Harnessing Esco's

experience of close to 30 years in clean air

and containment equipment design for the

pharmaceutical industry, these booths offer

dependable performance in compliance with

the latest environmental and operator safety

standards.

Laboratory operations involving weighing,

mixing and dispensing hazardous or nuisance

powders can now be performed safely and

economically with the Esco Powdermax 1

Powder Weighing Balance Enclosure.

Backed by decades of experience, the

Cleanroom product line offer state-of-the-art

designs compliant to the latest international

standards.

Integrated sourcing from the world’s leading

component suppliers including Swedish

Camfil-Farr® HEPA/ULPA filters, German ebm-

papst blowers and fans, enables us to meet

your Cleanroom Equipment requirements at

a competitive price with rapid delivery.

Product lines: •Downflow Booths.

• Powder Weighing Balance

Enclosures.

• Cleanroom Products.

- Air Showers.

- Pass Box and Transfer Hatches.

- Soft / Hard Capsule.

- Laminar Flow Straddle Units, Single

and Double.

- Garment Storage Cabinets.

Pictured: Containment / Pharma Products

8Esco Solution for Containment / Pharma Applications

Containment / Pharma Products

Esco Product Guide

Sleek, reliable and intuitive, Esco CelCulture CO2 incubators

provide comprehensive sample protection that brings your

scientific dreams one step closer to reality.

Esco CelCulture - world class CO2 Incubator from Esco with the best temperature and CO2 control providing superior protection and the best environment for cell cultures.

Features: • precise parameter control

- best uniformity and control among

competition, which means samples are

evenly heated

- fast recovery without overshoot to

ensure uniform CO2 levels even with

frequent door opening

- direct heat and air jacket for rapid

temperature recovery and provide

isolation from ambient temperature

fluctuations

- forced convection system accelerates

recovery of chamber air after door

closing to prevent contamination

• robust contaminat ion contro l

for optimum protection of your

samples using:

- ULPA filter

- validated 90ºC moist heat

decontamination

- filtered gas injection lines

- Isocide antimicrobial coating

• to provide maximum safeguarding of your cell cultures, all CelCulture CO2 incubators can be used with Voyager

Software

- a l lows automat ic , cont inuous

monitoring of device parameters

- with alarms to aler t user

when exceeding pre-defined

parameter limits

- allows user to configure devices

remotely Pictured: CelCulture® CO2 Incubators

Cradle for Beautiful Cells

CO2 Incubators

9

The Safe, Energy Efficient Solution for Modern Chemistry

Ductless Fume Hoods

Esco Ascent Ductless Fume Hoods provide protection to

both laboratory personnel and the environment from toxic

fumes.

Esco Ascent Ductless fume hoods are a

sensible balance of quality, performance

and cost-effectiveness. Fume containment

and airflow uniformity meet the

requirements of ASHRAE 110-1995, BS

7258, EN 14175-3 and AFNOR NFX 15-

203.

Key benefits:

• Low cost

- no ductwork required

- no exhaust system required

- Saves the need for elaborate make-up

air systems, in turn saving running costs

required to condition make-up air

• Convenience

- minimal installation expense

- mobile, flexible and can be easily

relocated

• Environmentally friendly

- personnel and env i ronmenta l

protection with the use of NanocarbTM

carbon filters

- saves energy as there is no need for

complicated ducting and make-up air

systems

Pictured: Ductless Fume Hoods

10

Esco Product Guide

The Esco suite of IVF equipment is the best choice for proven

safety and performance for the IVF laboratory.

Pictured: IVF Workstation, CO2 Incubator with Suppressed O2

Esco In Vitro Fertilization Equipment

In Vitro Fertilization Equipment

Product lines:

• Labculture IVF Workstation is especially

designed for use in fertility laboratories

for research work in the fields of human

and animal reproduction:

- warmed worktop keeps temperature

at a constant 37ºC ± 0.4ºC for proper

growth and cultivation of cells

- enhanced filtration system to provide

the highest level of air quality within

the workzone

- optional integration of microscope

and LCD

•CelCulture CO2 Incubator with

Suppressed O2 is an important

requirement in IVF applications as

oxygen is essential in the growth of

cells:

- precise temperature, CO2 control,

O2 control, and high humidity: stable,

uniform distribution and fast recorvery

without overshoot

- robust contaminat ion control :

ULPA filter, validated 90ºC moist

heat decontamination, ISOCIDE

antimicrobial powder coating, filtered

gas injection lines

- CelAlert system reminds user

to replace expired/depleted parts

11

Esco Solution for Animal Research Laboratories

Lab Animal Research Products

Animal research, cage changing and bedding disposal

procedures are now simpler, safer and more productive with

the Esco range of VIVA® Lab Animal Research Products.

Esco’s experience in clean air and

containment technologies extends to lab

animal research products to help protect

the investigator, animal technicians,

animals, and the environment during

research, cage changing and bedding

disposal procedures.

VIVA lab animal research products

help laboratories comply with NIOSH

recommendations to create a safer,

healthier, more productive work

environment and to ensure that this is

achieved, operator and environment

protection of each VIVA workstation was

evaluated through the ELISA analysis.

Actual cage changing and bedding

disposal operations were performed

to simulate how the workstations are

used, and allergen concentration at

designated areas was sampled. The

allergen concentration was quantified

using sandwich ELISA method.

The result: VIVA Workstations offer

high levels of operator and environment

protection that can substantially help to

minimize the allergen exposure.

Product lines:

•Universal Access Animal Containment Workstations.

•Dual Access Animal Containment Workstations.

• B e d d i n g D i s p o s a l A n i m a l Containment Workstations.

•Air Showers.Pictured: Lab Animal Research Products

12

Esco Product Guide

Laboratory fume hoods serve to control exposure to toxic, offensive or flammable vapors, gases and aerosols.

Pictured: Laboratory Fume Hoods

Laminar Topography and Perfect Protection Perimeter

Laboratory Fume Hoods

Esco Laboratory Fume Hoods are among the

best in the world, compliant with international

standards such as the American ASHRAE 110-

1995 and the British BS 7258, independently

tested by INVENT-UK. They have also been

successfully tested for fume containment

specified in the European Standard EN 14175-3

and received Underwriters Laboratories, USA

Classification under the fume hood standard

UL 1805, tested for fire, electrical, and

mechanical hazards.

Features: •Durable construction made of

industrial-grade electro-galvanized

steel with corrosion and abrasion

resistant, oven-baked, powder-coated

finish.

• Precisely tuned aerodynamic design

eliminates air turbulence, minimizes

noise levels and static pressure losses.

• Constant volume/high performance

concept eliminates the need for

complex VAV systems.

• Designed with computational

fluid dynamics ensuring maximum

containment, therefore enhancing

safety.

• Ergonomically designed for operator

comfort and convenience.

• Isocide antimicrobial coating prevents

surface contamination and inhibits

bacterial growth.

• ASHRAE 110 and EN 14175 certified

and UL classified.

Product lines:

•General Purpose Benchtop Hoods.

•Acid Digestion Hoods.

• Perchloric Acid Hoods.

• Radioisotope Hoods.

• Floor Mounted Hoods.

•High Performance, Low Flow Hoods.

• Educational Hoods.

• Polypropylene Hoods.

• Chemical Fume Scrubbers.

• Exhaust Blowers.

13

Reliable Performance For Universal Applications

Laboratory Ovens and Incubators

Introducing Esco Isotherm® - world class laboratory ovens

and incubators from Esco with the technologies and

compliance to prove it.

Esco Isotherm® - world class laboratory

ovens and incubators encompass

ergonomics, intuit ive interfaces,

microprocessor PID controls with

programming options, a 4-zone heated

air jacket and a precisely tuned and tested

ventilation and insulation package, all

supported by Esco’s solutions - based sales

and service representatives worldwide.

To prov ide the h ighest leve l of

consistency and protection, all Esco

ovens and incubators are Voyager

compatible:

- a l lows automat ic , cont inuous

monitoring of device parameters

- with alarms to alert user when

exceeding pre-defined parameter

limits

- allows user to configure devices

remotely

Product lines:

• Forced Convect ion Laboratory

Ovens.

• Forced Convect ion Laboratory

Incubators.

• Low Temperature Incubators.

• Sta in less Steel Opt ions for a l l

sizes of Ovens, Incubators & Low

Temperature Incubators.

Pictured: Laboratory Ovens and Incubators

14

Esco Product Guide

Esco is an industry leader in the development of professional quality laminar flow clean bench cabinets. With tens of thousands sold throughout the life sciences market worldwide, Esco has reinforced its reputation for dependability by providing reliable protection for samples and work processes in a multitude of applications.

Our selection of Vertical, Horizontal and Specialty clean bench cabinets offers a variety of choices for installations where high quality construction is essential. Our clean bench cabinets are aerodynamically engineered and use only premium quality ULPA filters with integrated motor/blower assemblies for quiet operation and long service life.

Since 1978, Esco has emerged as the industry leader producing laminar flow

cabinets that are the premium selection for the discerning researcher and offering a combination of value, high quality construction, low operating noise levels, and a wide product range to suit all budgets.

Esco is the world leader in premium laminar flow cabinets for the global life sciences market.

Pictured: Laminar Flow Clean Benches

The Leading Solution for Research Laboratories

Laminar Flow Clean Benches

15

Esco Reliable Solution for PCR Process

PCR Products

Esco PCR products are used in genomics, proteomics, molecular biology and forensic sciences where DNA amplification is required.

The Swift PCR thermal cycler series offers

a wide range of interchangeable reaction

modules that can be swapped in seconds

without tools. The Real-time PCR 96 has the

unique patented block dissipation technology

and bottom detection mode, providing better

heating /cooling rate, temperature accuracy,

uniformity and stability.

Features: •Flexible platform with its

interchangeable blocks and 3 different

modes of operation

• Advanced gradient function with

wider range of gradients

• Long-lasting key components for

reliable performance

• User friendly controls and operation

• Long warranty period wipes your

worries away

Because of the high copy number generated

during PCR, it is also essential to prevent

possible contamination of the PCR samples.

Contamination control and PCR process

repeatability is simplified with the Esco

range of PCR cabinets.

•HEPA filtered laminar air flow provides

superior sample protection

• Integrated UV lamp for rapid

decontamination of the work zone

between experiments, preventing

cross-contamination

• Ergonomically designed for maximum

operator comfort

- Low noise

- Angled front

- Glass sides

- Curved work surface front edge

- Powder coated rear wall eliminates

reflections

- Vertical airflow minimizes direct

airflow to user, causing dry eyesPictured: PCR Products, PCR Thermal Cyclers are not available in North America

16

Pictured: PCR Cabinet

Esco Product Guide

The Perfect Storage Environment for Beautiful Cells.

Highest Reliability, Top Performance

Ultralow Temperature Freezers

17

Pictured: Lexicon® Ultralow Temperature Freezers Series

Ultra-low temperature (ULT) freezers are widely used in scientific research for long-term storage of samples. As ULT freezers are often operated at -80°C continuously for years, reliability is of paramount importance to researchers.

Esco has used industry-accepted Highly Accelerated Life Testing (HALT) to stress test a large number of Lexicon Freezers at extreme conditions. All Lexicon freezers passed these extreme stress tests insuring a design that is optimized to protect your precious samples.

In accordance with ANSI/ASHRAE 72-2005 and ARI 1200-2006/2008 guidelines and as tested by a UL validated third party test lab, DNS USA, the Esco Lexicon ULT Freezer surpassed the performance of 5 major competitors with lower energy consumption, superior cabinet performance (as measured by warm-up time), and demonstrated a larger BTU refrigeration

reserve capacity to insure the highest level of performance and protection of your samples.

Features: •Fast Pull Down Time

• Fast Temperature Recovery After

Door Opening

• Excellent Cabinet Uniformity

• Extended Warm-up Time During

Power Failure

• Large Cooling Reserve

• Quiet - Low Noise Operation

• Low Energy Consumption

• Low Heat Emission To Ambient

• Superior Insulation System

• QuickOpenTM Fast Door Re-Open

System

• For additional safeguarding of your

samples, all Lexicon ULT freezers

are compatible with Voyager

software

Esco After Sales Services

After Sales Services

Parts Availability

Whenever service is needed and parts are required, minimizing downtime is a critical objective. Statistical usage analysis helps

Esco predict parts life, permitting Esco to manage logistics and stage proper inventories around the world. The combination of

predictive maintenance, historical data and geospecific proximity assures our customers that parts and labor are available whenever

service is scheduled through the local sales organization.

Registration, Documentation and Instruction

Quality control at Esco extends from research and development through engineering,

manufacturing, shipment, delivery and customer feedback. Esco maintains an

aggressive program to encourage warranty card registration by mail, email or online

submittal so that we know where Esco products are located and how they are being

used. Data from our warranty registration program is confidential and provides us

with valuable contact information should we ever need to notify you about your

Esco product.

All Esco products include unique serial numbers for identification.

Documentation for all performance tests is archived and maintained for customer

reference.

Online Technical Information

Site preparation instructions are useful before product arrival and installation.

Installation and start-up manuals, operations manuals and quick reference guides

are available anytime from the Esco Library online. An interactive online LiveSupport™

concierge center accessible through the Esco Web site offers extended hours of

operation. LiveSupport permits users to dialogue directly with Esco personnel.

References and Links

For more about Esco products, markets, employment opportunities, history,

education, information resources, and Singapore, visit our information portal at

www.escoglobal.com.

LIVE SUPPORTescoglobal.com

LIVE SUPPORTescoglobal.com

18

EscoMicroPte.Ltd.•21ChangiSouthStreet1•Singapore486777Tel+6565420833•Fax+6565426920•mail@escoglobal.comwww.escoglobal.com

EscoTechnologies,Inc.•2940TurnpikeDrive,Units15-16•Hatboro,PA19040,USAToll-FreeUSAandCanada877-479-3726•Tel215-441-9661•Fax215-441-9660us.escoglobal.com•usa@escoglobal.com

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Esco Global Offices | Beijing, China | Kuala Lumpur, Malaysia | Manama, Bahrain | Guangzhou, China |Hanoi, Vietnam | Melaka, Malaysia | Mumbai, India | Philadelphia, PA, USA | Salisbury, UK | Shanghai, China | Seoul, Korea | Delhi, India | Osaka, Japan | Manila, Philippines | Singapore