graduate school of medical sciencemedical research, we aim at determine molecular pathomechanisms of...
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GRADUATE SCHOOL OFMEDICAL SCIENCE
Anatomy Medicine Ⅰ(Respiratory) Surgery Ⅰ(Chest Surgery) Advanced Techno-Surgery
Anatomy and Developmental Biology Medicine Ⅱ(Endocrinology and Hypertension)
Surgery Ⅱ(Breast, Endocrine, Pediatric Surgery) Gene Medicine
Pathology Ⅰ (Department of Human and Experimental Pathology and Neuroscience)
Medicine Ⅲ(Diabetes and Metabolic syndrome) Cardiovascular Surgery Organ Replacement
Pathology Ⅱ(Human and Molecular Pathology) Medicine Ⅳ(Nephrology) Department of Therapeutic Strategy for
Severe Heart Failure Tissue Regeneration
Microbiology and Immunology Cardiology Gastroenterological Surgery Integrated Medical Sciences
Physiology Ⅰ(Neurophysiology) Gastroenterology Chemotherapy on Digestive Organs Cooperative Major in Advanced Biomedical Sciences
Physiology Ⅱ(Molecular and Cellular Physiology) Neurology Neurosurgery
Biochemistry Hematology Orthopedic Surgery
Pharmacology Psychiatry Plastic and Reconstructive Surgery
Hygiene and Public Health Ⅰ(Occupational and Environmental Health)
Pediatrics Ophthalmology
Hygiene and Public Health Ⅱ(Epidemiology and Preventive Medicine)
Dermatology Otolaryngology
Legal Medicine Radiation Oncology Obstetrics and Gynecology
International Affairs and Tropical Medicine
Diagnostic Imaging and Nuclear Medicine Anesthesiology
Medical Education Urology
Oral and Maxillofacial Surgery
Critical care and Emergency medicine
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About usOur ma in research f ocus i s t he mo lecu la r mechan isms regu la t ing ce l l p ro l i f e ra t ion and d i f f e rent ia t ion du r ing re t i na l deve lopment and regenera t ion . W e a lso s tudy on the neura l c i r cu i t r y i n h ippocampal and pa rah ippocampa l a reas o f t he b ra in , t he deve lopment o f t he human sku l l and the mechan ism o f a r te r ia l ca l c i f i ca t ion du r ing os teoporos is . As we teach g ross ana tomy to med ica l s tuden ts , t he g ross ana tomy course inc lud ing lec tu res and cadaver d i ssec t ion i s a l so o f fe red i f reques ted.
ANATOMY
Research1 ) M ec hanis ms r e gu la t ing t he p r o l i f e ra t ion a nd d i f fe re nt ia t ion o f r e t ina l c e l l s d u r i ng de ve l opme ntT h e r e t i na i s a p a r t o f t h e c e n t ra l n e r vo u s s ys t e m c o n s i s t i n g o f 6 t yp e s o f n e u r o ns a n d 1 t yp e o f g l i a
( Mü l l e r g l i a ) . Du r i n g d e ve lo p m en t , r e t i n a l p r o g en i t o r c e l l s i n c r e a se t h e i r n u m b e r b y p r o l i f e ra t i o n , b u t e ve n t u a l l y e x i t t h e c e l l c yc l e a n d d i f f e re n t i a te i n t o s p e c i f i c c e l l t yp e s . Mo le c u la r m e c h a n i s ms r e g u la t i ng t h i s p r o c e ss a r e o n l y p a r t i a l l y u n d e r s too d . W e s t u d y t h e r o l e o f c e l l c yc l e r e g u la to rs , t r a ns c r i p t i o n f a c to rs , a n d e p ig e n e t i c f a c to rs i n t h e d e ve lo p in g r o d e n t r e t i n a u s i n g h i s t o l o g i ca l a n d m o le c u la r b i o l o g i c a l t e c h n iq u es .T h e g e n e o f i n t e re s t i s i n j e c t ed i n t o t h e s u b r e t i n a l s p a c e o f t h e n e wb o r n r a t r e t i n a , e l e c t ro po ra teda n d t h e e xp r e s s ion a n a l yze d a f t e r 3 d a ys .
( 2 ) Ret ina l ne ur ona l r e ge ne ra t ion by M ü l le r g l i aI n l o we r ve r t eb ra tes l i k e f i s h , Mü l l e r g l i a d e d i f f e ren t i a te t o r e t i n a l p r o g en i t o r s , p r o l i f e ra te a n d
r e d i f f e re n t i a te t o n e u r o ns wh e n t h e r e t i n a i s d a m a g e d . Ho we ve r , s u c h r e g e ne ra t i ve c a p a c i t y o f Mü l l e r g l i a i n m a mmals i s ve r y l im i t e d . W e a r e i n ve s t i g a t i ng t h e m e c h a n i sms t h a t l im i t t h e r e g e nera t i ve p o t e n t i a l o f Mü l l e r g l i a a n d e xp lo r i n g t h e s t r a teg y t o r e p a i r d a m a g ed r e t i n a b y a c t i va t i ng t h e e n d o g en ou s r e g e n era t i ve p o t e n t i a l o f t h e m a mma l i a n r e t i n a .
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ANATOMY
( 3 )Morpholog ica l a na l ys i s o f m e m ory c i r cu i ts i n t he m a m mal ian s pe c ie s .3 D r e c o n s t ru c t i o n o f t h e r a t r e t i n a , e xp la n t e d a f t e r MNU- in d u c e d p h o t o rec ep to r d a m a g e . Mü l l e r g l i a , wh i c h e n t e r t h e c e l l c yc l e ( Ed U p o s i t i ve , r e d ) r e d i f f e re n t i a te i n t o p h o t o rec ep to rs ( Re c o ve r i n p o s i t i ve , g r e en ) . B lu e , DAP I n u c le a r s t a i n .I t i s p r e d i c ted t h a t t h e m o s t e s s e n t i a l p o r t i o n o f t h e m e mo ry c i r c u i t i s g e n e ra l l y p r e s e rve d f r om
r o d e n ts t o p r im a tes . T o e l u c i d a te s u c h f u nd amenta l c o n n e c t i o ns , we i n ve s ig a te n e u r o na l c o n n e c t i o n s b e t we e n t h e h i p p o c a mpu s a n d p a r a h ip po camp a l c o r t i c es ( i . e . , t h e p r e s u b i c u lu m, p a r a su b i c u lum, a n d e n t o rh i n a l c o r t ex ) i n s e ve r a l m a mma l i a n s p e c ie s i n c l u d in g t h e r a t s , r a b b i t s a n d m a r mose ts . S t a n d ard t r a ce rs , s u c h a s HRP, CT B , a n d BDA, a r e i n j e c t ed i n t o t h e h i p p o c a mpa l b o d y o r s e ve r a l p a r a h ip po camp a l c o r t i c es , wh i c h a l l o ws i n ve s t i g a t i o n o f t h e i n p u t -a nd -ou tp u t c o n n e c t i on s b e t we e n t h e s e a r e a s o n t h e c e l l m a s s l e ve l . W e a l s o u s e t h e p a lG FP - exp res s ing S in d b i s v i r u s ve c t o r t o a n a l yze a xo n a l a r b o r i za t i o ns a n d t e rm in a t i o n s o f s i n g le n e u r o n s .
( 4 )Morpholog ica l a na l ys i s o f t he c om m iss ura l e n t o r h ino-den ta te f i be rs f o l low ing u n i la te ra l e n t o r h ina l l e s ion . I t i s k n o wn t h a t , f o l l o w in g u n i l a t e ra l l e s i o n o f t h e e n t o rh i n a l c o r t e x o f t h e a d u l t r a t , t h e d e n e r va te d
g r a nu le c e l l s o f t h e d e n t a te g y r u s a r e r e i n n e rva te d a s a r e s u l t o f t h e g r o wt h o f t h e p a t h wa y f r om t h e s u r v i v i n g c o n t ra l a te ra l e n t o rh i n a l c o r t e x . T o i n ve s t i g a te t h e m o rp h o lo g i ca l f e a tu res o f s p r o u te d c o m mis sura l e n t o rh i n o -d en ta te f i b e rs f r om s i n g le e n t o rh i n a l n e u r o n s , we u s e t h e p a lG FP - e xp ress ing S in d b i s v i r u s ve c t o r a s t h e a n t e rog ra de t r ac e r . T h e ve c t o r i s u s e f u l f o r t r a c i n g l o n g a n d h i g h l y a r b o r i ze d a xo n a l b r a n ch es a n d i t i s p o s s ib l e t o d e t e c t s o m e u n k n o wn m o r ph o lo g i c a l c h a n g e s i n t h e r e i n n e rva te d f i b e rs . O u r s t u d y m a y c o n t r i b u te t o u n d e r s ta n d ing t h e m e c h a n i sms o f s p o n ta ne ou s r e c o ve ry f r om m e m ory im p a i r men t , wh i c h i s c a u s e d b y d e g e n era t i o n o f t h e e n t o rh i n a l c o r t ex .
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ANATOMY
( 5 )Morphoge ne s is o f t he hum a n f e t a l c r a n ia l bone s .A l t h o u g h t h e re h a s b e e n i n t e r es t i n t h e m o r ph og en es i s o f t h e h u m a n f e ta l c r a n ia l b o n e s f o r m a n y ye a r s , t h e 3 D r e s u l t s h a ve o n l y b e e n p u b l i s h e d a s s c h e mat i c i l l u s t r a t i o ns i n a u t h o r i ze d t e x t bo ok s b e c a u s e o f t h e l a c k o f a c c e p tab le o b s e r va t i o n t e c h n iq ue s . W e i n ve s t i g a te t h e m o rp h og en es i s o f t h e h u m a n f e ta l t e m pora l b o n e u s in g ve r y h i g h r e s o lu t i o n CT ( μ - CT ) . T o m og rap h i c im a g e s o f t h e c o c h le a o f t h e h u m a n f e tu s . T h e i n t e rn a l s t r uc tu re o f t h e c o c h le a i s n o t c l e a r l y s e e n b y s t a n d ard m e d i c a l CT ( a ) . By c o n t ras t , t h e r e s o lu t i o n o f μ CT i s m u c h h i g h e r a n d t h e Re i s s n e r ’ s m e mb ran e ( 2 c e l l t h i c k ) i s c l e a r l y v i s u a l i ze d ( b ) .
( 6 ) Loc a l cor re la t ions betw ee n ca lc i f i ed ar te r ios c ler os i s and rar e fac t ion o f b on e s (os te op or o s is ) .W e in ve s t i g a te t h e l o c a l c o r r e l a t i o n s b e t we e n c a l c i f i e d a r t e r i o sc l e ro s i s a n d r a r e fa c t i on o f b o n e s ( o s te op oros i s ) b y t h e b o n e m o r ph omet r y b a s e d o n t h e μ - CT im a g e o f t h e l o we r l e g s o f t h e a r t e r i o sc l e ro s i s o b l i t e r an s ( ASO) p a t i e n t s d e r i ve d f r om d ia b e t es a n d o xa lo s i s ( d i a l ys i s ) a n d t h e i r c o n t ro l g r o up s . Ph o t o e le c t r i c s p e c t ro sc op y a n d i n v i v o SPECT w i t h 9 9 m -Tc -HMDP u s in g r a b b i t s s u g g es te d t h a t e c t o p i c b o n e f o rmat i o n i s i n vo l ve d i n t h e c a l c i f i c a t i o n . E lu c i d a t i o n o f t h e m e c h an i sm o f t h i s c o r re l a t i o n i s im p o r ta n t b e c a u s e t h e 2 n d a n d 3 r d p l a c e s o f t h e c a u s e o f d e a t h o f o u r c o u n t r y a r e va s c u la r d i s e a s e s a n d t h e p o p u la t i o n o f o s t e op oro t i c p a t i e n t s i s ve r y h i g h i n a g in g s o c ie t y .
( 7 ) De c r e a s e o f t he e f f ec t o f X - r a y r a d i a t ion e x pos ure .I f we c a n a p p l y μ - CT f o r t h e c l i n i c a l u s e , i t wo u ld b e e x t r eme l y u s e f u l f o r t h e e a r l y d e t e c t i o n o f d i s e a s e s , d e ve lo p m e nt o f t h e t h e ra p y a n d t h e s t u dy o f t h e e xp e r ime n ta l m e d i c i n e . Ho we ve r , μ - CT c a n n o t b e u s e d f o r t h e l i v i n g h u m a n b o d ie s w i t h o u t e n o r mou s q u a n t i t y o f r a d ia t i o n e xp o s u re . T o s o l ve t h i s p r o b le m, we a r e a t t empt i n g t o d e c r ea se t h e e f f ec t o f X - r ay r a d ia t i o n e xp o s u r e a n d c u r re n t l y e xp lo r i n g h o w t o c o n t ro l t h e v i t a l r e a c t i o n o f ・O H, i n c o l l a b o r a t i o ns w i t h o t h e r u n i ve r s i t i e s .
Faculty
H i r o k i F u j i e d a Y o s h i k o H o n d a T a k a s h i S h i b a t a T o r u H a y a k a w a F u m i n o r i S a i t o h N o r i h i r o S u d o u K a o r i N o m u r a - K o m o i k e
publication
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About usT h e d e p a r t m e n t wa s fo u n d e d in Fe b r u a r y, 1 9 5 6 a s S e c o n d D e p a r t m e n t o f A n a to my by P ro fe s s o r M o r i o I h n u m a ( t i l l M a r c h , 1 9 85) t a k in g c h a r g e o f h i s to lo g y. A f te r h i s r e t i r e m e n t , P ro fe s s o r E i z oA ikawa d i r e c ted t h e d e p a r t m e n t a n d p ro c e e d e d to e m b r yo lo g y in a d d i t i o n to h i s to lo g y ( f ro m S e p te m b e r, 1 9 8 8 t i l l M a r c h , 2 0 01) . T h e n a m e o f t h e d e p a r t m e n t wa s c h a n g e d to De p a r t m e n t o f A n a to my & Deve lo p m e n t a l B io lo gy in A p r i l 1 9 92 . T h e d e p a r t m e n t h a s b e e n d i r e c te d by Ta i c h iE z a k i f ro m Ku m a m o to Un i ve r s i t y s in c e M ay, 2 0 01 .T h e a im s o f o u r e d u c a t ion p ro g r a m a r e to d e m o n s t r a te t h e b e a u t y, exq u i s i te n es s a n d h ete ro g e n e i t y o f l i v in g c r e a t u r e s a n d to c o n s id e r t h e r e la t io n s h ip b et we e n t h e i r m o r p h o lo gy a n d b i o l o g i ca l f u n c t ion . T h e d e p a r t m e n t i s i n c h a r g e o f C y to lo g y & H is to lo g y a n d H u m a n e m b r yo lo g y & C o m p a r a t i ve e m b r yo lo g y. S t u d e n t s l e a r n g e n e r a l h u m a n m ic ro s c o p ic a n a to my a n d t h e m e c h a n is m s o f e m b r yo g e n e s i s d u r in g t h e c o u r s e o f i n te g r a te d c u r r i c u lum fo r t h e u n d e r g r a d u a te m e d ic a l e d u c a t io n in To k yo Wo m e n ' s M e d ic a l Un i ve r s i t y .
ANATOMY AND DEVELOPMENTAL BIOLOGY
ResearchT h e d e p a r t m e n t i s o p e n to a l l s t u d e n t s a n d s c ie n t i s t s w h o a r e in te r e s ted in a ny m o r p h o lo g i ca l a p p ro a c h e s to m e d ic a l b io lo g y. O u r s t r a te g ie s a r e a va r ie t y o f m o r p h o lo g i ca l te c h n iq u es i n c l u d ing p o l yc h ro m a t ic im m u n o h is to c h e m is t r y, i n s i t u hy b r id i za t io n , a n d c o m p u te r - ba s e d im a g e a n a l y s e s fo r 3 - d e m e n s ion a l s t r u c t u r e s . T h e m a in f a c i l i t i es ava i la b le a r e f l u o r e s c en t l i g h t m i c ro s c o py, p h a s e - c o n t r as t m ic ro s c o py, N o m a r s k i d i f fe r en t ia l - in te r fe r e nc e - co n t r a s t m ic ro s c o py, c o n fo ca l l a s e r s c a n n in g m ic ro s c o py, t r a n s m is s io n e le c t ro n m ic ro s c o py, a n d s c a n n in g e l e c t ro n m ic ro s c o py. B o t h in v i vo a n im a l o p e r a t io n s y s te m a n d in v i t ro c e l l c u l t u r e s y s te m a r e a l s o u n d e r t a ke n in a d d i t i o n to va r io u s a p p ro a c h e s in m o le c u la r b io lo g y.
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ANATOMY AND DEVELOPMENTAL BIOLOGY
Faculty・Ta ic h i E z a k i ( P ro fe s s o r a n d C h a i r m a n ) M . D . , P h . D .・S h u n ic h i M o r ikawa ( S e n io r l e c t u r e r ) P h . D .・Ka z u h iko S h im iz u ( I n s t r u c to r ) P h . D .・S a c h iko K iku t a ( I n s t r u c to r ) P h . D .・S h u j i K i t a h a r a ( I n s t r u c to r ) D . D . S . , P h . D .・M a s a e M o r i s h im a ( I n s t r u c to r ) V. S . , P h . D .・Aya ko S e d o h a r a ( I n s t r u c to r ) P h . D .
publication
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About us1 s t D e p a r t m e n t o f P a t h o l o g y i s e n t r us t e d w i t h t h e f o l l o w i n g t h r e e m a j o r m i s s i o n s f o r T o k y o W o m e n ’ s M e d i c a l U n i v e r s i t y : ( 1 ) m e d i c a l e d u c a t i o n o n t e a c h i n g e t i o l o g y a n d p a t h o m e c h a n i s m s o f c o m m o n a n d r a r e d i s e a s e s , ( 2 ) m e d i c a l r e s e a r c h o n m o l e c u l a r p a t h o l o g y a n d n e u r o s c i e n c e f o r m e d i c a l s t u de n t , g r a d u a t e s c h o o l s t u d e n t a n d r e s e a r c h f e l l o w s ; a n d ( 3 ) m e d i c a l c o n t r i b u t i o n b y d i a g n o s t i c a c t i v i t i e s o n p a t h o l o g i c a l a n a t o m y a n d s u r g i c a l p a t h o l o g y . I n m e d i c a l e d u c a t i o n , w e r e g a r d a c t i v e l e a r n i n g c o n c e r n i n g p a t h o p h y s i o l o g y b a s e d o n m o r p h o l o g i c a l a n d f u n c t i o n a l c h a n g e s o f s e v e r a l o r g a n s . I n m e d i c a l r e s e a r c h , w e a i m a t d e t e r m i n e m o l e c u l a r p a t h o m e c h a n i s m s o f h u m a n d i s e a s e s u s i n g m a t e r i a l s o b t a i n e d f r o m h u m a n t i s s u e s a s w e l l a s e x p e r i m e n t a l a n i m a l s a n d c u l t u r e d c e l l s a s d i s e a s e m o d e l s , w h i c h m a y b e i n t u rn d i r e c t e d t o e s t a b l i s h m e n t o f n o v e l t h e r a p e u t i c s t r a t e g i e s . I n p a t h o l o g i c a l a n a t o m y , w e m a k e p a t h o p h y s i o l o g i c a l s t o r i e s , w h i c h o c c u r r e d i n t h e b o d y o f d i e d p a t i e n t s , c l e a r , a n d m a k e u s e o f t h e o b t a i n e d r e s u l t s a n d a s s e s s m e n t s f o r t h e f u t u r e . I n s u r g i c a l p a t h o l o g y , w e w o r k p r o m p t l y a n d p r a c t i c a l l y a n d p r o v i d e i n f o r m a t i o n t h a t i s u s e f u l f o r c h o o s i n g t h e m o s t s u i t a b l e m e d i c a l s e r v i c e o n t h e l i v i n g p a t i e n t s .
PATHOLOGY Ⅰ( D E PA RT M E N T O F H U M A N A N D
E X P E R I M EN TA L PAT H O L O G Y A N D N E U R O S C I E N C E )
Research( 1 ) M o l e c u l a r m e c h a n i s m s o f m o t o r n e u r o n d e a t h i n a m y o t r o p h i c l a t e r a l s c l e r o s i s( 2 ) C a n c e r c e l l m e t a b o l i s m t a k i n g i n t o c o n s i d e r a t i o n f o r e s t a b l i s h m e n t o f n o v e l t h e r a p e u t i c s t r a t e g i e s( 3 ) M o l e c u l a r m e c h a n i s m s o f a c c u m u l a t i o n a n d n e u r o t o x i c i t y o f n e u r o d e g e r a t i v e d i s e a s e - r e l a t e d g e n e p r o d u c ts( 4 ) M o l e c u l a r m e c h a n i s m s o f a c t i v a t e d m i c r o g l i a a n d r e a c t i v e a s t r o c y t e s i n p e n u m b ra a t a c u t e s t a g e o f i s c h e m i c s t r o k e( 5 ) M o l e c u l a r m e c h a n i s m s o f a t h e r o s c l e r o s i s( 6 ) M o l e c u l a r p a t h o l o g y o f n e o v a s c u l i z a t i o n i n g l i o m a( 7 ) I n v o l v e m e n t o f f u k u t i n i n m a t u r a t i o n a n d p r o l i f e r a t i o n o f s e v e r a l t y p e s o f c e l l s( 8 ) M o l e c u l a r m e c h a n i s m s o f i n v a s i o n a n d m e t a s t a s i s o f t h y r o i d c a n c e r s( 9 ) M o l e c u l a r m e c h a n i s m s o f p o s t n a t a l n e u r o g e n e s i s
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Faculty
N o r i y u k i S h i b a t a ( P r o f e s s o r & C h a i r m a n ) t a k i n g c h a r g e o f ( 1 ) ( 2 ) ( 4 ) ( 5 )T a t s u o S a w a d a ( P r o f e s s o r ) t a k i n g c h a r g e o f ( 6 )K a z u h i k o W a t a b e ( V i s i t i n g P r o f e s s o r ) t a k i n g c h a r g e o f ( 3 ) T o m o k o Y a m a m o t o ( A s s o c i a t e P r o f e s s o r ) t a k i n g c h a r g e o f ( 7 ) M o t o k o N i i d a - K a w a g u c h i ( L e c t u r e r ) t a k i n g c h a r g e o f ( 1 ) ( 9 ) Y o i c h i r o K a t o ( A s s i s t a n t P r o f e s s o r ) t a k i n g c h a r g e o f ( 3 ) ( 8 ) K e n t a M a s u i ( A s s i s ta n t P r o f e s s o r ) t a k i n g c h a r g e o f ( 2 )
publication
PATHOLOGY Ⅰ( D E PA RT M E N T O F H U M A N A N D
E X P E R I M EN TA L PAT H O L O G Y A N D N E U R O S C I E N C E )
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About usP a t h o l o g y i s t h e s t u dy o f c a u s e , o r i g i n a n d n a t u r e o f d i s e a s e . W e c o n t r i b u t e t o t h e c l i n i c a l s e r v i c e s i n c l u d i n g s u r g i c a l p a t h o l o g y a n d a u t o p s i e s , r e s e a r c h a n d m e d i c a l s c h o o l e d u c a t i o n . W e c o n d u c t r e s e a r c h u t i l i z i n g m o l e c u l a r b i o l o g i c a l t e c h n i q u e s , w h i c h b r i d g e t h e g a p b e t w e e n m i c r o s c o p i c - l e v e l r e s p o n s e t o c e l l u l a r d a m a g e a n d m o l e c u l a r m e c h a n i s m s i n v o l v e d i n d i s e a s e d e v e l o p m e n t . B e c a u s e a l l p a t h o l o g i s t s i n o u r d e p a r tm e n t h a v e b a c k g r o u n d o f c l i n i c a l e x p e r i e n c e , c l i n i c a l q u e s t i o n s t h a t a r i s e f r o m c l i n i c a l w o r k w i l l b e t h e t a r g e t o f o u r r e s e a r c h . T h e t e c h n i c i a n s h a v e e x c e l l e n t s k i l l s t o s u p po r t o u r w o r k f r o m c l i n i c a l d i a g n o s i s t o l a b o r a t o r y r e s e a r c h . W e h a v e a f r i e n d l y a t m o s p h e r e . P l e a s e f e e l f r e e t o d r o p i n o u r d e p a r tm e n t .
PATHOLOGY Ⅱ(HUMAN AND MOLECULAR PATHOLOGY)
ResearchR e s e a r c h i n o u r d e p a r t m e n t i s b r o a d a n d v a r i e d , a n d a l l i n v e s t i g a t o r s f o c u s o n h u m a n d i s e a s e . S o m e o f u s s t u d y c a n c e r a n d t r y t o u n d e r s t a n d t h e m o l e c u l a r m e c h a n i s m s o f t u m o r g r o w t h a n d m e t a s t a s i s t h r o u g h m i t o c h o n dr i a l m o r p h o l o g y . O t h e r r e s e a r c h i n t e r e s t s a r e v a s c u l a r c a l c i f i c a t i o n a n d a b n o r m a l b o n e m e t a b o l i s m , m e t a b o l i c f a t t y l i v e r d i s e a s e , a n d p a t h o g e n e s i s o f F S G S a n d d i a b e t i c n e p h r o p a t h y , u t i l i z i n g e l e c t r o n m i c r o s c o p y , f l u o r e s c e n c e m i c r o s c o p e , a n d F A C S a n a l y s i s , b e s i d e s m o l e c u l a r m e t h o d o l o g y . W e h a v e l a b m e e t i n g s r e g u l a r l y w i t h t h e w h o l e s t a f f m e m b e r s t o h e l p f o c u s o n o u r r e s e a r c h g o a l s . W e h o p e t o c o n d u c t b a s i c / c l i n i c a l r e s e a r c h i n c o l l a b o r a t i o n w i t h o t h e r d i v i s i o n s o r i n s t i t u t i o n s .
FacultyH i d e a k i O d a , P r o f e s s o r , C h a i r o f t h e S e c o n d D e p a r tm e n t o f P a t h o l o g yS e k i k o T a n e d a , A s s i s t a n t p r o f e s s o r ( p a t h o g e n e s i s o f F S G S a n d d i a b e t i c n e p h r o pa t h y )K e n t a U t o , R e s e a r c h a s s o c i a t e ( V a s c u l a r c a l c i f i c a t i o n a n d a b n o r m a l b o n e m e t a b o l i s m )S a e k o K a n a i , R e s e a r c h a s s o c i a t e ( V a s c u l a r c a l c i f i c a t i o n a n d a b n o r m a l b o n e m e t a b o l i s m )A k a n e Y a m a u c h i , R e s e a r c h a s s o c i a t e ( R e g u l a t i o n o f m i t o c h o n d r i a i n t u m o r i g e n e s i s )
publication
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About usT h e D e p a r tm e n t o f M i c r o b i o l o g y a n d I m m u n o l o g y c o v e r s a r a n g e o f f i e l d s i n r e s e a r c h a n d i n t e a c h i n g , f r o m i m m u n o l o g y , w h i c h s t u d i e s h o w t h e i m m u n e s y s t e m o f t h e b o d y p r o t e c ts i t s e l f f r o m i n f e c t i o u s d i s e a s e s , t o m i c r o b i o l o g y , w h i c h f o c u s e s o n m i c r o b i a l s t r u c t u re , g e n e t i c s a n d m e t a b o l i s m . O u r b a s i c r e s e a r c h i s u n d e r ta k e n i n c l o s e c o l l a b o r a t i o n w i t h t h e u n i v e r s i t y h o s p i t a l p h y s i c i a n s , f o r t h e a i m t o u n d e r s ta n d h o w h o s t i m m u n e r e s p o n s e e n d e a v o r s t o o v e r c o m e m i c r o b i a l i n f e c t i o n , a n d h o w p a t h o b i o n t s e l i c i t p a t h o g e n e s i s t o i n f l a m m a t i o n , a u t o i m m u n i t y , a n d a l l e r g y .
MICROBIOLOGYAND IMMUNOLOGY
Research( 1 ) A n t i g e n - i n d uc e d i m m u n e r e s p o n s e s o f T c e l l s a n d B c e l l s : M e c h a n i s m s u n d e r l y i n g d i f f e r e n t i a t i o n a n d m a t u r a t i o n o f l y m p h o c y t e s i n r e s p o n s e t o a l l o - , a u t o - a n d s u p e r - a n t i g e n s w i l l b e s t u d i e d b y u s i n g e x p e r i m e n t a l m i c e . ( 2 ) T c e l l m a t u r a t i o n a n d a g i n g : I n v e s t i g a t i o n i n t o T c e l l r e s p o n s e s f r o m n e w b o r n s t o t h e e l d e r l y i n h u m a n s w i l l p r o v i d e i n s i g h t s i n t o h o w t o c o m b a t a g e - r e l a t e d i m m u n e - a n t i g e n i n t e r a c t i o n s , i n i n f e c t i o n , c a n c e r a n d a u t o i m m u n e d i s e a s e s .( 3 ) I m m u n e c e l l s i n i n f l a m m a t o r y d i s e a s e s : K i n e t i c s o f i n n a t e a n d a c q u i r e d i m m u n e c e l l s w i l l b e a n a l y z e d i n c o r r e l a t i o n w i t h g u t m i c r o b i o t a , i n a u t o i m m u n e d i s e a s e s , a l l e r g y a n d m e t a b o l i c s y n d r o m e . P a t h o g e n i c f a c t o r s c o n t r i bu t i n g t o h o s t r e s p o n s e s w i l l b e c h a r a c t e r i z e d i n t h e a i m t o s e e k i t s u n d e r l y i n g p a t h o g e n e s i s f o r p r i m a r y i n f l a m m a t o r y d i s e a s e s . ( 4 ) I n f e c t i o n - i n d u c e d s h o c k : E x o t o x i n s o f s t a p h y l o c o c c i a n d s t r e p to c o c c i w i l l b e u t i l i z e d i n s y s t e m i c s h o c k i n d u c t i o n . I n n a t e , a c q u i r e d a n d h u m o r a l i m m u n e r e s p o n s e s , a s w e l l a s s h o c k - i n h i b i t o r s , w i l l b e a n a l y z e d i n m i c e t o c l a r i f y t h e m e c h a n i s m b y w h i c h e x o t o x i n s e l i c i t p a t h o g e n e s i s i n t h e i n f e c t e d h o s t .( 5 ) M o l e c u l a r a n d b i o c h e m i c a l a n a l y s i s o f d e n o v o s u p e r a n t i g e n s : S t r u c tu r a l a n d f u n c t i o n a l a n a l y s i s w i l l b e e l u c i d a t e d o n t h e s u p e r a n t i g e n s d e t e c t e d a n d p u r i f i e d f r o m s h o c k p a t i e n t s .
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MICROBIOLOGYAND IMMUNOLOGY
FacultyP r o f e s s o r , C h i e f L e c t u r e r J u n j i Y a g iA s s o c i a t e P r o f e s s o r N a o k o Y a n a g i s a w aL e c t u r e r T o s h i f u m i O s a k aA s s o c i a t e L e c t u r e r H i d e h i t o K a t oA s s i s t a n t P r o f e s s o r M i y u k i M i y a k eA s s i s t a n t P r o f e s s o r S h i g e r u A s h i n o
publication
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About usH o w i s o u r b r a i n c i r c u i t a s s e m b l e d d u r i n g t h e c o u r s e o f d e v e l o p m e n t a n d h o w d o e s t h e m a t u r e n e t w o r k r e s p o n d t o t h e c h a n g e s i n e n v i r o n m e n t a l c u e s ? I n o r d e r t o t a c k l e t h e s e q u e s t i o n s , w e e m p l o y m u l t i p l e l e v e l s o f t e c h n i q u e s i n c l u d i n g t h e m o l e c u l a r b i o l o g y , m o u s e g e n e t i c s , h i s t o l o g y , i n v i t r o s l i c e a s w e l l a s i n v i v o e l e c t r o p h y s i o l o g y a n d t h e a n i m a l b e h a v i o r . W e a c t i v e l y i n v o l v e r e s e a r c h e s w i t h l a b o r a t o r i e s f o r c l i n i c a l m e d i c i n e a n d a l s o w e l c o m e y o u t o j o i n o u r l a b o r a t o r y a s P h D s t u de n t f r o m c l i n i c a l d e p a r t m e n t .
PHYSIOLOGY Ⅰ(NEUROPHYSIOLOGY)
Research( 1 ) R e w i r i n g m e c h a n i s m o f n e u r o n a l c i r c u i t s i n t h e c e n t r a l n e r v o u s s y s t e mN e u r a l c i r c u i t s a r e d r a m a t i c a l l y r e f i n e d u n d e r t h e i n f l u e n c e o f e x t e r n a l e n v i r o n m e n t s a n d e x p e r i e n c e s d u r i n g d e v e l o p m e n t . E v e n t h o u g h n e u r a l c i r c u i t s h a v e r e a c h e d f u l l m a t u r i t y , t h e r e w i r i n g o f c i r c u i t s c a n o c c u r a g a i n a f t e r d e a f f e r e n t a t i o n s u c h a s t h e l i m b a m p u t a t i o n . S y n a p s e s i n t h e s e n s o r y t h a l a m u s a r e k n o w n t o u n d e r g o t h e s y n a p t i c r e w i r i n g d u r i n g p o s t n a t a l d e v e l o p m e n t a n d d e a f f e r e n t a t i o n . W e e x a m i n e t h e r e g u l a t i o n o f s y n a p t i c f u n c t i o n u n d e r t h e s y n a p t i c r e m o d e l i n g i n t h e s o m a t o s e n s o r y s y s t e m u s i n g a c o m b i n a t i o n o f t o o l s i n v i v o a n d i n v i t r o , i n c l u d i n g e l e c t r o p h y s i o l o g i c a l a n d i m a g i n g t e c h n i q u e s , a s w e l l a s g e n e t i c a l l y m a n i p u l a t e d m i c e .( 2 ) M e c h a n i s m s u n d e r l y i n g p o s tn a t a l d e v e l o p m e n t o f s e n s o r y s y n a p s e s a n d m a i n t e n a n c e a f t e r m a t u r a t i o nT h e e l i m i n a t i o n o f e a r l y - f o r m e d r e d u n d a n t s y n a p s e i s a f u n d a m e n t a l p r o c e s s f o r t h i s d e v e l o p m e n t a l r e f i n e m e n t o f n e u r a l c i r c u i t s . A f t e r m a t u r a t i o n , t h e n e u r a l c i r c u i t s a r e m a i n t a i n e d . W e e x p l o r e m e c h a n i s m s o f t h i s s y n a p s e p r u n i n g d u r i n g d e v e l o p m e n t a n d t h e s y n a p t i c m a i n t e n a n c e u s i n g e l e c t r o p h y s i o l o g i c a l t e c h n i q u e s i n c o m b i n a t i o n w i t h p h a r m a c o l o g i c a l a n d / o r m o l e c u l a r b i o l o g i c a l m e t h o d s .
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( 3 ) T o w a r d s e l u c i d a t i n g t h e e n d o p h e n o t y p e s o f a u t i s m s p e c t r u m d i s o r d e r s ( A S D )B y u t i l i z i n g d e v e l o p m e n t a l g e n e t i c s s t r a t e g i e s , w e w e r e a b l e t o e s t a b l i s h m o u s e m o d e l s w i t h s o c i a l a n d w o r k i n g - m e m o r y d e f i c i t s . I n a d d i t i o n t o t h e g e n e t i c a n d m o l e c u l a r m e c h a n i s m s u n d e r l y i n g t h e s e b e h a v i o r a l p h e n o t y p e s , w e e x a m i n e t h e c o r t i c a l n e t w o r k s a n d s y n a p t i c p r o p e r t i e s .
FacultyP r o f e s s o r a n d C h a i r p e r s o n M a r i k o M I Y A T AA s s i s t a n t P r o f e s s o r Y u k i K I U C H I ( Y A G A S A K I )A s s i s t a n t P r o f e s s o r H i r o n o b u O S A K IA s s i s t a n t P r o f e s s o r Y o s h i f u m i U E T AA s s i s t a n t P r o f e s s o r G o i c h i M I Y O S H IP a p e r s : h t t p : / / w w w . t w m u . a c . j p / B a s i c / p h y s i o l 1 / p u b l i c a t i o n - e . h t m l
publication
PHYSIOLOGY Ⅰ(NEUROPHYSIOLOGY)
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About usP h y s i o l o g y i s a n i m p o r t a n t a c a d e m i c f i e l d o n f u n c t i o n s o f l i v i n g o r g a n i s m s . P h y s i o l o g i c a l r e s e a r c h a i m s t o u n d e r s t a n d t h e m e c h a n i s m s h o w l i v i n g o r g a n i s m s l i v e . D e p a r t m e n t o f P h y s i o l o g y I I i s i n v o l v e d i n m o l e c u l a r a n d c e l l u l a r p h y s i o l o g i c a l r e s e a r c h . W e a r e s t u d y i n g t h e f u n c t i o n o f g e n e s a n d p r o t e i n s u s i n g t h e f a s t - g r o w i n g i n f o r m a t i o n o f g e n o m e s c i e n t i f i c u n d e r s t a n d i n g s . W e u s e g e n e t i c a l l y - m o d i f i c a t i o n t e c h n o l o g y a n d R N A i n t e r e f e r e n c e s t o c o n t r i b u te m e d i c a l s c i e n c e s a n d p h y s i o l o g y .
PHYSIOLOGY Ⅱ(MOLECULAR AND CELLULAR PHYSIOLOGY)
Research( 1 ) M o l e c u l a r g e n e t i c a n a l y s e s o n v e s i c u l a r t r a f f i c k i n g( 2 ) M o l e c u l a r g e n e t i c a n a l y s e s o n n e u r o n a l d e v e l o p m e n t v i a t r a n s c r i p t i o n f a c t o r s( 3 ) D e v e l o p m e n t o f g e n e t h e r a p y b y R N A i n t e r e f e r e n c e s( 4 ) P a t h o p h y s i o l o g i c a l a n a l y s e s o n c e l l d e a t h( 5 ) M e c h a n i s m s o f d i s e a s e s r e l a t e d t o e n d o p l a s m i c r e t i c u l u m ( 6 ) M e c h a n i s m o n t h e m a i n t e n a n c e o f p l u r i p o t e n c y i n t h e s t e m c e l l s
FacultyS h o h e i M i t a n i , S a w a k o Y o s h i n a , S a y a k a H o r i ,Y u j i S u e h i r o , K a t s u f u m i D e j i m a ,T o m o k o M o t o h a s h i publication
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About usB i o c h e m i s t r y i s a s c i e n t i f i c f i e l d t o t r y t o u n d e r s t a n d l i f e p h e n o m e n a i n t h e m o l e c u l a r l e v e l . U n d e r s t a n d i n g o f l i f e p h e n o m e n a i n c l u de s e l u c i da t i o n o f s t r u c t u r e - f u n c t i o n c o r r e l a t i o n a n d i t s r e g u l a t i o n i n h e a l t h a n d d i s e a s e .W e a r e c o n d u c t i n g r e s e a r c h o n s t r u c t u r e - f u n c t i o n c o r r e l a t i o n o f c e l l m e m b r a n e s , e s p e c i a l l y o n f u n d a m e n t a l i s s u e s r e g a r d l e s s t h a t t h e y m a y b e o u t o f f a s h i o n , b a s e d o n u n i q u e i d e a s a n d s t r a t e g i e s . W e m a i n l y u s e h u m a n r e d b l o o d c e l l s a s t h e b e s t m a t e r i a l f o r m e m b r a n e r e s e a r c h , b e c a u s e i ) t h e s u b j e c t i n m e d i c a l s c h o o l s h o u l d b e h u m a n , a n d h u m a n r e d b l o o d c e l l s a r e r e a d i l y a v a i l a b l e . i i ) R e d b l o o d c e l l s a r e i n d i s pe n s a b l e f o r l i f e . i i i ) M e m b ra n e f u n c t i o n s ( d e f o r m a b i l i t y a n d m e m b r a n e s t a b i l i t y ) c a n b e q u a n t i t a t e d . i v ) M e m b r a n e a b n o r m a l i t i e s r e s u l t i n d i s e a s e s , i . e . , h e m o l y t i c a n e m i a , o r m a l a r i a p a r a s i t e i n v a s i o n .
BIOCHEMISTRY
Research( 1 ) M a i n t e n a n c e a n d r e g u l a t i o n o f r e d c e l l m e m b r a n e f u n c t i o n ( c e l l m o r p h o l o g y , d e f o r m a b i l i t y , a n d
m e m b r a n e m e c h a n i c a l s t a b i l i t y ) .( 2 ) I n t e r a c t i o n b e t w e e n v a r i o u s r e d c e l l m e m b r a n e p r o t e i n s ( m e a s u r e m e n t o f a d i s s o c i a t i o n c o n s t a n t ,
a n d a s s o c i a t i o n o r d i s s o c i a t i o n r a t e c o n s t a n t s )( 3 ) M e c h a n i s m ( s ) f o r m o d u l a t i o n o f m e m b r a n e p r o t e i n f u n c t i o n s b y p o s t t r a n s l a t i o n a l m o d i f i c a t i o n s
s u c h a s p h o s p h o r y l a t i o n o r g l y c a t i o n .( 4 ) M e c h a n i s m ( s ) f o r m a i n t e n a n c e a n d d i s r u p t i o n o f a s y m m e t r i c d i s t r i b u t i o n o f p h o s p h o l i p i d s i n l i p i d
b i l a y e r . I d e n t i f i c a t i o n o f f l i p p a s e a n d s c r a m b l a s e a n d e l u c i d a t i o n o f m e c h a n i s m ( s ) t h r o u g h w h i c ht h e i r f u n c t i o n s a r e m o d u l a t e d .
( 5 ) M e c h a n i s m ( s ) f o r d y i n g o f h u m a n r e d c e l l s , w h i c h l a c k n u c l e i . E l u c i d a t i o n o f m e c h a n i s m s f o r t w o“ e a t m e s i g n a l s ” , c l u s t e r i n g o f b a n d 3 a n d e x p o s u r e o f P S t o t h e o u t e r l e a f l e t .
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BIOCHEMISTRY
( 6 ) M e c h a n i s m ( s ) f o r m a l a r i a p a r a s i t e i n v a s i o n o f r e d c e l l s : t r i a l t o p r e v e n t p a r a s i t e i n v a s i o n .( 7 ) S e l f - o r g a n i z a t i o n h y p o t h e s i s o f m e m b r a n e a r c h i t e c t u re . A n a l y s i s o f s i n g l e - m o l e c u l e f l u c t ua t i o n .( 8 ) M e c h a n i s m ( s ) f o r d e g r a n u l a t i o n i n m a s t c e l l s . C l a s s i f i c a t i o n o f , a n d m e m b r a n e f u s i o n b e t w e e n
d i s t i n c t c l a s s e s o f g r a n u l e s .( 9 ) I n v e s t i g a t i o n s o f t h e r e d c e l l m e m b r a n e f r o m p a t i e n t s s u c h a s h e m o l y t i c a n e m i a ( i n c o r r o b o r a t i o n
w i t h m a n y h o s p i t a l s ) .
FacultyF u m i o N a k a m u r a ( p ro f e s s o r )I c h i r o K o s h i n o ( l e c t u re r )S h o t a r o T a n a k a ( a s s i s t a n t p r o f e s s o r ) N o b u t o A r a s h i k i ( a s s i s t a n t p r o f e s s o r )Y u j i H e n m i ( a s s i s t a n t p r o f e s s o r )M i k i k o I t oT o m o h i k o I w a k a m iM a y u m i E n o k i
publication
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About usW e f o c u s o n c a n c e r - a n d i n f l a m m a t i o n - r e l a t e d g e n e s i n t u m o r c e l l p r o l i f e r a t i o n a n d m e t a s t a s i s a n d h a v e b e e n i n v e s t i g a t i n g r o l e s o f t h o s e g e n e s i n a m e t a s t a t i c p r o c e s s c o m p o s e d b y t u m o r g r o w t h a t p r i m a r y s i t e , e x t r a v a s a t i o n , i n t r a v a s a t i o n , a n d r e g r o w th a t m e t a s t a s i z e d s i t e s . W e a l s o e x a m i n e e f f e c t s o f p r i m a r y t u m o r s o n t u m o r m i c r o e n v i r o n m e n t a n d p r e - m e t a s t a t i c o r g a n s . W e u s e v a r i o u s e x p e r i m e n t a l m a t e r i a l s s u c h a s v a s c u l a r e n d o t h e l i a l , b o n e m a r r o w , p u l m o n a r y e p i t h e l i a l , l i v e r , a n d i m m u n e c e l l s w i t h v a r i o u s e x p e r i m e n t a l t e c h n i q u e s , a n d e a c h r e s e a r c h e r v i g o r o u s l y p r o m o t e s o w n r e s e a r c h p r o j e c t a t o w n d i s c r e t i o n .
PHARMACOLOGY
Research( 1 ) S i g n a l t r a n s du c t i o n i n c a n c e r
1 ) M o l e c u l a r f u n c t i o n s o f o n c o g e n e a n d t u m o r s u p p r e s s o r2 ) C e l l u l a r p h a r m a c o l o g y o f t u m o r - b e a r i n g o r l e u k e m i a m o d e l m i c e
( 2 ) M o l e c u l a r b i o l o g y o f v a s c u l a r e n d o t h e l i a l c e l l s1 ) G r o w t h f a c t o r s i g n a l i n g2 ) V a s c u l a r d e v e l o p m e n t
( 3 ) M o l e c u l a r b i o l o g y o f R e a c t i v e o x y g e n s p e c i e s ( R O S ) - r e l a t e d s i g n a l1 ) R e g u l a t i o n o f g e n e e x p r e s s i o n b y R O S a n d / o r f r e e r a d i c a l s2 ) M o l e c u l a r m e c h a n i s m s o f R O S p r o d u c t i o n
( 4 ) M o l e c u l a r b i o l o g y o f c h a p e r o n s1 ) M o l e c u l a r f u n c t i o n s o f H e a t s h o c k p r o t e i n s(H S P - 5 4 , - 7 0 , - 9 0) i n s t r e s s s i g n a l2 ) D y s f u n c t i o n o f H S P s i n p a t h o p h y s i o l o g i c a l s e t t i n g s3 ) M o l e c u l a r i n t e r a c t i o n s r e g u l a t e d b y c h a p e r o n s a n d d r u g s
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( 5 ) M o l e c u l a r b i o l o g y o f s t e r o i d - r e s p o n s i v e f a c t o r s1 ) R e g u l a t o r y m e c h a n i s m o f t h e g l u c o c o r t i c o i d r e c e p to r2 ) R e g u l a t o r y m e c h a n i s m o f s t e r o i d - r e l a t e d s i g n a l b y g l u c o c o r t i c o i d r e c e p t o r - b i n d i n g p r o t e i n s
PHARMACOLOGY
FacultyP r o f . Y o s h i r o M a r uD e g r e e : M . D . , P h . D .R e s e a r c h i n t e r e s t : I n f l a m m a t i o n a n d M e t a s t a s i s , C M L , a n g i o g e n e s i sP a p e r s : h t t p : / / w w w . t w m u . a c . j p / B a s i c / y a k u r i / p a pe r . h t m l
publication
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About usP h y s i c a l a n d c h e m i c a l f a c t o r s p r e s e n t i n b o t h g e n e r a l a n d o c c u p a t i o n a l e n v i r o n m e n t s a f f e c t o u r h e a l t h . M u c h a t t e n t i o n h a s b e e n p a i d i n r e c e n t t i m e s t o e n v i r o n m e n t a l e x p o s u r e t o t o x i c m e t a l s , d i o x i n s , p e r s i s t e n t o r g a n i c p o l l u t a n t s , v o l a t i l e o r g a n i c c o m p o u n d s a n d f i n e p a r t i c u l a t e m a t t e r , a s w e l l a s t o t h e e f f e c t s o f g l o b a l e n v i r o n m e n t a l i s s u e s o n p u b l i c h e a l t h . W o r k p l a c e e x p o s u re t o o r g a n i c s o l v e n t s a n d m e t a l c o m p o u n d s r e m a i n s a k e y f a c t o r t h a t c a u s e s h a r m f u l c l i n i c a l o r s u b c l i n i c a l i n t o x i c a t i o n . T h e p r i m a r y o b j e c t i v e o f r e s e a r c h i n o u r l a b o r a t o r y i s t o c l a r i f y t h e m o l e c u l a r m e c h a n i s m s o f t o x i c c h e m i c a l - i n d u c e d c e l l d y s f u n c t i o n a n d c e l l d e a t h ( o r c e l l p r o l i f e r a t i o n ) u s i n g t h e t e c h n i q u e s o f m o l e c u l a r a n d c e l l u l a r b i o l o g y . I d e n t i f i c a t i o n o f s i g n a l i n g m o l e c u l e s t h a t p r o m o t e c e l l s u r v i v a l o r c e l l d e a t h i s i m p o r ta n t f o r d e s i g n i n g p r e v e n t i v e s t r a t e g i e s a g a i n s t t o x i c c h e m i c a l - i n du c e d c e l l u l a r d a m a g e . I n a d d i t i o n t o i n v i t r o s t u d i e s , z e b r a f i s h ( D a n i o r e r i o ) a n d t h e n e m a t o d e C . e l e g a n s a r e u t i l i z e d a s m o d e l o r g a n i s m s i n t h e s e t o x i c o l o g i c a l r e s e a r c h p r o j e c t s . O u r r e c e n t r e s e a r c h i n t e r e s ts a r e f o c u s e d o n s i g n a l t r a n s d uc t i o n p a t h w a y s t h a t l e a d t o a p o p to s i s a n d a u t o ph a g y , e n d o p l a s m i c r e t i c u l u m ( E R ) s t r e s s a n d s u b s e q ue n t u n f o l d e d p r o t e i n r e s p o n s e ( U P R ) . I n a d d i t i o n t o t h e a b o v e a r e a s o f l a b o r a t o r y i n v e s t i g a t i o n , s t u d i e s o n w o m e n ’ s h e a l t h a n d o c c u p a t i o n a l h e a l t h a r e o n g o i n g p r o j e c ts i n o u r d e p a r tm e n t . W e h o p e t o w e l c o m e m a n y y o u n g r e s e a r c h e r s t o w o r k w i t h u s o n m o l e c u l a r a n d c e l l u l a r t o x i c o l o g y r e s e a r c h p r o j e c t s .
HYGIENE AND PUBLIC HEALTH Ⅰ
( O C C U PAT I O N A L A N D E N V I R O N M E N TAL H E A LT H )
Research1 . E f f e c t s o f t o x i c m e t a l s o n t h e s i g n a l i n g p a t h w a y s r e s p o n s i b l e f o r c e l l s u r v i v a l / de a t h2 . R o l e o f E R s t r e s s a n d U P R i n t o x i c c h e m i c a l - i n d uc e d c e l l d e a t h3 . T o x i c o l o g i c a l s t u d i e s o n t h e c e l l u l a r d a m a g e i n d u c e d b y n a n o - s i z e d f i n e p a r t i c l e s4 . D e v e l o p m e n t a l t o x i c o l o g y u s i n g z e b r a f i s h a s a m o d e l o r g a n i s m5 . M o l e c u l a r m e c h a n i s m s o f t h e n e u r o t o x i c s u b s t a n c e a c r y l a m i de6 . I n v e s t i g a t i o n o f o c c u pa t i o n - r e l a t e d d i s e a s e s a n d t h e i r p r e v e n t i o n
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FacultyM a s a t o M a t s uo k a , M . D . , P h . D .M i c h i k o N o h a r a , M . D . , P h . D .Y u t a K o m o i k e , P h . D .K o t a F u j i k i , P h . D .T a k a m i t s u M i y a y a m a , P h . D .
publication
HYGIENE AND PUBLIC HEALTH Ⅰ
( O C C U PAT I O N A L A N D E N V I R O N M E N TAL H E A LT H )
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About usT h e D e p a r tm e n t o f P u b l i c H e a l t h w a s f o u n d e d b y P r o f e s s o r H i r o t o Y o s h i o k a a n d h a s b e e n c h a i r e d b y P r o f e s s o r N a o h i t o Y a m a g u c h i s i n c e 2 0 0 2 . W e p r o v i d e e d u c a t i o n a l p r o g r a m s a n d c o n d u c t s r e s e a r c h e s a b o u t p u b l i c h e a l t h , w h i c h t r e a t s v a r i o u s g l o b a l h e a l t h i s s u e s f o r h e a l t h p r o m o t i o n .W e o f f e r h i g h q u a l i t y e d u c a t i o n i n p u b l i c h e a l t h f o r p r e p a r i n g t h e n e x t g e n e r a t i o n o f r e s e a r c h e r s a n d p h y s i c i a n s i n t h e f i e l d o f p u b l i c h e a l t h , a s w e l l a s d i s s e m i n a t i o n o f k n o w l e d g e t o h e a l t h p r o f e s s i o n a l s a n d t h e g e n e r a l p u b l i c . W e a r e c o m m i t te d t o t h e e n h a n c e m e n t o f q u a l i t y o f h e a l t h n o t o n l y i n o u r o w n c o u n t r y , b u t i n t e r n a t i o n a l l y .
HYGIENE AND PUBLIC HEALTH Ⅱ
( E P I D E M I OLO GY A N D P R E V E N T I V E M E D I C I N E )
I n o u r r e s e a r c h e s , w e a s s e s s t h e d i s t r i b u t i o n a n d d e t e r m i n a n t s o f h u m a n i l l n e s s w i t h t h e a i m o f e s t a b l i s h i n g r e a s o n e d p r e v e n t i v e m e a s u r e s b y u s i n g e p i d e m i o l o g i c a l m e t h o d . W e i n v e s t i g a t e t h e e t i o l o g y o f d i s e a s e i n h u m a n p o p u l a t i o n s , e v a l u a t e h e a l t h c a r e d e l i v e r y , d e v e l o p m e t h o d o l o g y f o r t r a n s l a t i n g e p i d e m i o l o g i c r e s e a r c h f i n d i n g s i n t o c l i n i c a l m e d i c i n e , a n d d e v e l o p a p p r o a c h e s f o r a p p l y i n g t h e f i n d i n g s o f e p i d e m i o l o g i c r e s e a r c h i n t h e f o r m u l a t i o n o f p u b l i c p o l i c y . W e m a k e c o n t i n u o u s e f f o r t s t o i m p r o v e m e t h o d s f o r e p i d e m i o l o g i c a l i n v e s t i g a t i o n , t o e n h a n c e v a l i d i t y a n d e f f i c i e n c y , a n d t o e x p a n d t h e s c o p e o f a c t i v i t i e s i n w h i c h e p i d e m i o l o g i c m e t h o d s c a n b e u s e f u l l y a p p l i e d .
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Research( 1 ) A n e p i d e m i o l o g i c a l s t u d y a n d r i s k a s s e s s m e n t f o r a c i r c u m s t a n c e o f u r b a n l i f e a n d h e a l t hW i t h a r a p i d c h a n g e i n u r b a n l i f e , t h e s a f e t y o f e n v i r o n m e n t a l f a c t o r s , w h i c h d i d n o t e x i s t b e f o r e , h a s o f t e n b e c o m e a p r o b l e m . W e a r e c o n d u c t i n g a c a s e - c o n t r o l s t u d y o n m o b i l e p h o n e u s e a n d b r a i n t u m o r i n c o l l a b o r a t i o n w i t h i n t e r n a t i o n a l r e s e a r c h i n s t i t u t i o n s . S t u d e n t s c a n u s e i n t h e s e e p i d e m i o l o g i c a l d a t a a n d g e t i n v o l v e d i n e a c h p h a s e s u c h a s d e v e l o p i n g a p l a n , c o n d u c t i n g a r e s e a r c h , c o l l e c t i n g i n f o r m a t i o n a n d a n a l y z i n g t h e d a t a . I n a d d i t i o n , s t u d e n t s c a n s y s t e m a t i c a l l y c o l l e c t r e l e v a n t m e d i c a l l i t e r a t u r e p u b l i s h e d t h r o u g h o u t t h e w o r l d , a n d p e r f o r m a r i s k a s s e s s m e n t f o r s a f e t y t h r o u g h t h e q u a l i t a t i v e a n d q u a n t i t a t i v e e v a l u a t i o n i n c l u d i n g m e t a - a n a l y s i s a n d p o o l e d a n a l y s i s . T h r o u g h t h e s e a c t i v i t i e s , s t u d e n t s c a n a c q u i r e a b i l i t y t o p l a n a n d c o n d u c t a n e p i d e m i o l o g i c a l s t u d y a n d f u r t h e r m o r e t o p e r f o r m a r i s k a s s e s s m e n t b a s e d o n s c i e n t i f i c e v i d e n c e .( 2 ) E p i d e m i o l o g i c a l s t u d i e s t h a t h a v e a p p l i e d b e h a v i o r a l s c i e n c e s a n d s o c i a l s c i e n c e sE p i d e m i o l o g i c a l s t u d i e s t h a t h a v e a p p l i e d b e h a v i o r a l s c i e n c e s ( b e h a v i o r a l e p i d e m i o l o g y ) r e v e a l t h e l a w o f h e a l t h b e h a v i o r o f p e o p l e b y s c i e n t i f i c i n v e s t i g a t i o n . E p i d e m i o l o g i c a l s t u d i e s t h a t h a v e a p p l i e d s o c i a l s c i e n c e s ( s o c i a l e p i d e m i o l o g y ) r e v e a l a b o u t t h e s o c i a l f a c t o r s t h a t d e f i n e t h e p e o p l e ’ s h e a l t h . I n o u r l a b o r a t o r y , w e h a v e b e e n c o n d u c t i n g s t u d i e s o n t h e c o n s c i o u s n e s s a n d t h e c h a n g e o f b e h a v i o r o f t h e e x e r c i s e a n d s t u d i e s o n c o n s c i o u s n e s s a n d b e h a v i o r o f q u i t s m o k i n g . I n t h i s p r o g r a m , w e w i l l d e c i d e t h e t h e m e , c r e a t e a r e s e a r c h p l a n , a n d c o n d u c t a s u r v e y . A n d t h e n w e w i l l c a r r y o u t t h e s t a t i s t i c a l a n a l y s i s a n d s t u d y a b o u t t h e e f f e c t o f b e h a v i o r a n d s o c i e t y t o t h e p e o p l e ’ s h e a l t h .
HYGIENE AND PUBLIC HEALTH Ⅱ
( E P I D E M I OLO GY A N D P R E V E N T I V E M E D I C I N E )
( 3 ) A s t u d y o n e p i d e m i o l o g i c a l e v a l u a t i o n o f c l i n i c a l p r a c t i c eW e a r e c o n d u c t i n g a s t u d y o n e p i d e m i o l o g i c a l e v a l u a t i o n o f d i a g n o s t i c a n d t h e r a p e u t i c a p p r o a c h e s i n c o l l a b o r a t i o n w i t h t h e o t h e r c l i n i c a l d e p a r t m e n t s . B a s e d o n t h i s p r o g r a m , w e c a n t a k e i n g r a d u a t e s t u d e n t s i n a c l i n i c a l d e p a r t m e n t f o r a c e r t a i n p e r i o d . T h e g r a d ua t e s t u d e n t s c a n p e r f o r m p r a c t i c a l t r a i n i n g , s u c h a s d e v e l o p i n g a s t u d y p l a n , c o n d u c t i n g a s t u d y a n d p e r f o r m i n g s t a t i s t i c a l a n a l y s e s , o n t h e s u b j e c t o f p r a c t i c a l c l i n i c a l i s s u e s .
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FacultyP r o f e s s o r a n d C h a i r m a n : N a o h i t o Y a m a g u c h iP r o f e s s o r o n j o i n t a p p o i n t m e n t : T a k a h i r o O k a m o t oA s s o c i a t e P r o f e s s o r : N o r i k o K o j i m a h a r aP a r t - t i m e A s s i s t a n t P r o f e s s o r : N a r u m i E g u c h iP a r t - t i m e A s s i s t a n t P r o f e s s o r : M a r i k o F u j i k a w aA s s i s t a n t P r o f e s s o r : Y a s u t o S a t oA s s i s t a n t P r o f e s s o r : M o t o k i E n d oA s s i s t a n t P r o f e s s o r : K o s u k e K i y o h a r a
publication
HYGIENE AND PUBLIC HEALTH Ⅱ
( E P I D E M I OLO GY A N D P R E V E N T I V E M E D I C I N E )
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About usT h e p r i m a r y r e s e a r c h t o p i c s c u r r e n t l y a d d r e s s e d b y t h e d i v i s i o n i n c l u de “ t r a u m a t i c b r a i n i n j u r y ” a n d “ a c c i d e n t d i a g n o s i s a n d p r e v e n t i o n . ”1 ) D i a g n o s i s o f a n d r e s e a r c h o n t r a u m a t i c b r a i n i n j u r y f o r m e d i c o l e g a l d e a t h i n v e s t i g a t i o nI n t e r p r e t i n g t h e s i t u a t i o n r e s u l t i n g f r o m a h e a d i n j u r y , a n d t h e c a u s a l r e l a t i o n s h i p b e t w e e n d a m a g e a n d d i s o r d e r , a r e r e q u i r e d i n f o r e n s i c m e d i c i n e . U n t i l n o w o u r r e s e a r c h h a s f o c u s e d o n n e r v e c e l l d e g e n e r a t i o n c a u s e d b y h e a d i n j u r y , n e u r o p a t h y c a u s e d b y f o r e i g n b o d i e s i n t h e b r a i n , a n d t h e r e l a t i o n s h i p b e t w e e n a c c i d e n t s a n d d e m e n t i a a m o n g t h e e l d e r l y . W e c o n t i n u e t o p u r s u e o u r r e s e a r c h , i d e n t i f y i n g i m p o r t a n t i s s u e s i n t h e c o u r s e o f o u r f o r e n s i c p r a c t i c e a n d v e r i f y i n g t h e m t h r o ug h m e t h o d s i n c l u d i n g e x p e r i m e n t s o n a n i m a l s t h a t e m p l o y b a s i c l a b o r a t o r y p r o c e d ur e s .2 ) A c c i d e n t D i a g n o s i s a n d P r e v e n t i o nM a j o r c a u s e s o f d e a t h i n c l u de f a l l s , a b n o r m a l e n v i r o n m e n t s , a c u t e i n t o x i c a t i o n , a n d t r a f f i c a c c i d e n t s , a n d r e s e a r c h i n g t h e i r d i a g n o s i s a n d p r e v e n t i o n i s n e c e s s a r y t o e n s u r e p u b l i c s a f e t y a n d p e a c e o f m i n d . W e a n a l y z e a c c i d e n t s i n v o l v i n g c h i l d r e n a n d t h e e l d e r l y , e x a m i n i n g a n d i n v e s t i g a t i n g t h e r e l a t i o n s h i p b e t w e e n a c c i d e n t s a n d e x i s t i n g o r l a t e n t c o n d i t i o n s a s w e l l a s c o m p l i c a t i o n s r e s u l t i n g f r o m a c c i d e n t s . A l s o , f o r p a t h o l o g i c a l c h a n g e s r e q u i r i n g a d e t e r m i n a t i o n o f c o n d i t i o n o r d a m a g e c a u s e d b y a n a b n o r m a l e n v i r o n m e n t a l , w e p e r f o r m h i s t o m o r ph o l o g i c a l a n d m o l e c u l a r - b i o l o g i c a l a n a l y s e s t o s t u d y c a u s e s a n d c o n d i t i o n s a n d t o d e t e c t i n f o r m a t i o n t h a t w i l l a s s i s t i n m a k i n g a d e t e r m i n a t i o n . F u r t h e r m o r e , w e a l s o r e s e a r c h t h e t o x i c o l o g i c a l a n d f o r e n s i c a s p e c t s o f t h e r e l a t i o n s h i p o f a c c i d e n t s t o d r u g s a n d t o x i c s u b s t a n c e s .
LEGAL MEDICINE
Research1 . D a m a g e t o t h e b r a i n c a u s e d b y h e a d i n j u r y : A n a l y z e d a m a g e t o t h e b r a i n c a u s e d b y h e a d i n j u r i e s t h r o u g h h i s t o m o r p h o l o g i c a l a n d m o l e c u l a r - b i o l o g i c a l a n a l y s e s u s i n g e x p e r i m e n t s o n a n i m a l s .2 . B r a i n c o n d i t i o n s c a u s e d b y a b n o r m a l e n v i r o n m e n t s : D e v i s e m e t h o d s o f a u t o p s y d i a g n o s i s b y u n d e r s ta n d i n g t h e m o r p h o l o g i c a l c h a n g e s i n t h e b r a i n c a u s e d b y h i g h a n d l o w b o d y t e m p e r a t u re .
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LEGAL MEDICINE
3 . F o r e n s i c p a t h o l o g y a n d c l i n i c a l f o r e n s i c m e d i c i n e : D e v i s e m e t h o d s o f a u t o p s y d i a g n o s i s o r s i c k n e s s a n d i n j u r y p r e v e n t i o n b y g a t h e r i n g a n d a n a l y z i n g e x a m p l e s o f s u d de n o r a c c i d e n t a l d e a t h .4 . D N A a n a l y s i s f o r p e r s o n a l i d e n t i f i c a t i o n
Faculty P r o f e s s o r K I B A Y A S H I , K a z u h i k o L e c t u r e r S H I M A D A , R y o L e c t u r e r T A K I , T a k a s h i A s s i s t a n t p r o f e s s o r N A K A O , K e n - i c h i r o A s s i s t a n t p r o f e s s o r M A C H I D A , M i t s u y o A s s i s t a n t p r o f e s s o r T A T A R A , Y u k i
publication
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About usO u r d e p a r t m e n t i s f o c u s e d o n f i e l d - o r i e n t e d r e s e a r c h o n g l o b a l h e a l t h a n d t r o p i c a l m e d i c i n e u s i n g o u r e x p e r i e n c e s o n g l o b a l c o o p e r a t i o n o f h e a l t h a n d r e s e a r c h n e t w o r k s f r o m h o m e a n d a b r o a d . F u r t h e r , w e a i m t o t r a i n e x p e r t s w i t h a g l o b a l p e r s pe c t i v e t h r o u g h r e s e a r c h e x p e r i e n c e s a n d s u p po r t t h e i r a c t i v i t i e s i n t h e g l o b a l c o m m u n i t y .
INTERNATIONAL AFFAIRSAND TROPICAL MEDICINE
Research1 . M a l a r i a p a r a s i t e s r e s i s ta n t t o a n t i m a l a r i a l d r u g sT h e P l a s m o d i u m f a l c i p a r u m h a s a w e l l - d e v e l o p e d a b i l i t y , t h r o u g h d i f f e r e n t p r o c e s s e s a n d m e c h a n i s m s , t o b e c o m e r e s i s t a n t t o a n t i m a l a r i a l d r u g s , b e i n g a c h a l l e n g i n g i s s u e f o r m a l a r i a c o n t r o l . A f t e r t h e d i s c o v e r y o f g e n e s i n t h e P l a s m o d i u m f a l c i p a r u m t h a t c o n f e r t h e r e s i s t a n c e t o a n t i m a l a r i a l d r u g s , t h e m o l e c u l a r m e c h a n i s m s o f t h e a c t i o n f o r r e s i s t a n c e a r e b e c o m i n g u n v e i l e d . T h e g e n e t i c e l e m e n t s c o d i n g f o r r e s i s t a n c e a r e c o n t a i n e d o n c h r o m o s o m a l a n d / o r o n e x t r a c h r o m o s o m a l ( M i t o c h o n d r i a l ) e l e m e n t s . A t t h e s a m e t i m e , m o l e c u l a r p o p u l a t i o n g e n e t i c a n a l y s e s u s i n g s o p h i s t i c a t e d m e t h o d s t o d e t e r m i n e t h e p a t t e r n s o f m i c r o s a t e l l i t e v a r i a b i l i t y f l a n k i n g t h e r e s i s t a n c e g e n e s h a v e e l u c i d a t e d t h e g e o g r a p h i c o r i g i n s a n d s p r e a d o f p a r a s i t e d r u g r e s i s t a n c e . T h u s , i n a d d i t i o n t o i t s m e c h a n i s t i c d e t a i l s , u n d e r s ta n d i n g o f e v o l u t i o n a n d s p r e a d o f d r u g r e s i s t a n c e p r o v i d e a r a t i o n a l e f o r p h a r m a c o l o g i c a l i n t e r v e n t i o n t o o v e r c o m e t h e e x a c e r b a t i o n a n d r a m p a n c y o f d r u g - r e s i s t a n t p a r a s i t e s i n t h e f i e l d s .
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INTERNATIONAL AFFAIRSAND TROPICAL MEDICINE
.2 . T r e a t m e n t c h o i c e o f c a r e t a k e r s o n t h e i r c h i l d ’ s a c u t e i n f e c t i o u s i l l n e s s e sT r e a t a b l e i n f e c t i o u s d i s e a s e s , s u c h a s m a l a r i a , p n e u m o n i a a n d d i a r r h e a , a r e t h e m a i n c a u s e o f d e a t h i n t h e d e v e l o p i n g c o u n t r i e s . H e a l t h s e r v i c e p r o v i s i o n w i t h p r o m p t a n d a d e q u a t e t r e a t m e n t i s t h e o n e o f m a i n d i s e a s e c o n t r o l s t r a t e g i e s a n d u n d e r s t a n d i n g o n t r e a t m e n t s e e k i n g b e h a v i o r i s e s s e n t i a l t o p r o m o t e u t i l i z a t i o n o f t h e h e a l t h f a c i l i t i e s . W e i n v e s t i g a t e t r e a t m e n t c h o i c e o f c a r e t a k e r s f o r t h e i r c h i l d i l l n e s s u s i n g e c o n o m e t r i c a n d e p i d e m i o l o g i c a l a n a l y s e s o n e m p i r i c a l d a t a f r o m a c o h o r t p o p u l a t i o n i n t h e d e v e l o p i n g c o u n t r i e s . O u r r e s e a r c h o u t c o m e s w i l l c o n t r i bu t e p o l i c y i m p l i c a t i o n s f o r d i s e a s e c o n t r o l .
FacultyT o m o h i k o S u g i s h i t a , p r o f e s s o rT a k a h i r o T s u k a h a r a , L e c t u r e rM i k i S a k u r a i , A s s i s t a n t p r o f e s s o rH a j i m e H o n m a , A s s i s t a n t p r o f e s s o r
publication
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About usT h e d e p a r t m e n t o f m e d i c a l e d u c a t i o n w a s e s t a b l i s h e d i n 1 9 9 5 f o l l o w e d b y a f o u n d a t i o n o f a c h a i r o f m e d i c a l e d u c a t i o n i n 2 0 0 3 . T h e r o l e o f o u r d e p a r t m e n t i s t o e x p l o r e h o w t o t h i n k , h o w t o t e a c h , a n d h o w t o e v a l u a t e i n o r d e r t o c r e a t e p r o p e r m e d i c a l e d u c a t i o n s y s t e m a d a p te d t o a c a d e m i c , m e d i c a l , a n d s o c i a l c h a n g e s . S o f a r w e h a v e i n t r o d u c e d n e w c u r r i c u l u m s , h a v e d e v e l o p e d n e w e d u c a t i o n a l m e t h o d s s u c h a s P r o b l e m - b a s e d L e a r n i n g ( P B L ) a n d T e a m - b a s e d L e a r n i n g ( T B L ) , a n d h a v e r e f o r m e d c l i n i c a l c l e r k s h i p .I n u n d e r g r a d ua t e m e d i c a l e d u c a t i o n w e t e a c h s t u d e n t s h o w t o s t u d y a s m e d i c a l s t u d e n t s t o b e c o m e p h y s i c i a n s . I n p o s t g r a d ua t e e d u c a t i o n w e t e a c h h o w t o t e a c h o t h e r s . I t i s a v e r y i n t e r e s t i n g t h e m e t o r e s e a r c h b r i n g i n g u p p e o p l e . W e w e l c o m e g r a d ua t e s t u d e n t s w h o a r e i n t e r e s t e d i n l e a r n i n g a t h e o r y o f t h e m e d i c a l e d u c a t i o n , d e v e l o p i n g n e w e d uc a t i o n s y s t e m , p r a c t i c i n g i t , a n d e v a l u a t i n g i t . Y o u c a n c o n t i n u e y o u r c l i n i c a l o r b a s i c m e d i c a l w o r k d u r i n g t h e t e r m s .
MEDICAL EDUCATION
Research( 1 ) D e v e l o p m e n t o f e d u c a t i o n a l s y s t e m( 2 ) D e v e l o p m e n t a n d e v a l u a t i o n o f O u t c o m e - b a s e d E d u c a t i o n ( O B E ) c u r r i c u l u m( 3 ) M e a s u re m e n t o f e d u c a t i o n a l e f f e c t s( 4 ) S t u dy o n p r o f e s s i o n a l i s m i n m e d i c a l s t u d e n t s a n d m e d i c a l d o c t o r s( 5 ) S t u dy o f l e a n i n g c h a r a c t e r i s t i c s a m o n g f e m a l e m e d i c a l s t u de n t s a n d s u p p o r t f o r c o n t i n u o u s
e m p l o y m e n t f o r f e m a l e d o c t o r s( 6 ) D e v e l o p m e n t o f t e a c h i n g s t r a t e g y a n d e v a l u a t i n g m e t h o d s o f c l i n i c a l d e c i s i o n m a k i n g
FacultyY u m i k o O k u b o ( P r o f e s s o r , c h a i r p e r s o n )K a g a r i M u r a s a k i ( E n d o w e d a s s o c i a t e p r o f e s s o r )T a i y o S u g a n u m a ( R e s e a r c h a s s o c i a t e )
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About usT h e F i r s t De p a r tme n t o f Me d i c i n e , T o k yo W ome n ’ s Me d i c a l Un i ve r s i t y i s o n e o f t h e l e a d in g i n s t i t u te s o f r e s p i ra to ry m e d i c i n e i n J a p a n . W e h a ve 2 6 0 0 0 o u t p a t i e n t s a n d 1 1 0 0 0 i n p a t i e n t s e ve r y ye a r i n o u r d e p a r tmen t . O u r c l i n i c a l f i e l d s c o ve r a l l r e s p i ra to ry d i s e a s e s s u c h a s p n e u m on ia , l u n g c a n c e r , b r o n c h ia l a s t hma, CO PD, p u lm o n ary f i b ros i s , s l e e p a p n e a s yn d r o me a n d s o o n . W e a l s o p e r f o rm b a s i c a n d c l i n i c a l r e s e a rch o n r e s p i ra to ry m e d i c i n e t o d e ve lo p t h e n e w m e t h od s a n d t h e rap ie s i n t h i s f i e l d . Es p e c ia l l y , o u r t h e me s a r e a s f o l l o ws ; a i r wa y i n f l a mmat i on a n d r e mo de l i n g i n a s t hma a n d CO PD, a i r wa y s e c r e t i o n , c h e m oth erap y o f l u n g c a n c e r , p u lm o n ary c i r c u l a t i on , r e s p i ra to ry r e h a b i l i t a t i o n , a n d n e w t e c h n iq u es o f b r o n ch os cop y . W e r e c e n t l y f o cu s o n t h e s t u d ie s u s i n g t h e t e c h n iq u es o f m o le c u la r b i o l o g y a n d c e l l u l a r p h ys io l o g y . W e h o p e e ve r yo n e c o m in g t o o u r i n s t i t u te a n d s t u d y in g w i t h u s .
MEDICINE Ⅰ(RESPIRATORY)
Research1 . C l i n ica l Re s e a r c hMa n a g e ment a n d t r e a tme n t i n a s t hma a n d CO PDRe s e a r ch o n a b n o rma l a i r wa y s e c r e t i o n i n c h r o n i c i n f l a mmato ry a i r wa y d i s e a s e s i n c l u d in g a s t hma, CO PD, DPB, a n d b r o n c h ie c tas i sE f f i c acy o f c h e m othe rap y i n l u n g c a n c e rA r e s e a rch o f d r i ve r o n c o g en e f o r l u n g c a n c e r u s i n g m ic r o s p e c im en b y a b r o n ch os co py2.Ba sic Re s e a r c h・Re m o de l i n g o f t h e a i r wa y d i s e a s e s・Re g u la t i o n o f s m o o th m u s c le c o n t ra c t i o n i n t h e a i r wa y a n d t h e p u lm o n ary va s c u la t u re・ I o n t r a n spo r t i n t h e a i r wa y e p i t h e l i u m・Ba s i c s t u d y t o wa r d s r e g en era t i ve m e d i c i n e・Ap o p to s i s a n d s e n e s c e nce o f t h e l u n g c e l l s
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Faculty P r o f e s s o r: J u n T a m a o k i A s s o c i a t e P r o f e s s o r:Mi t s u k o K o n d o A s s o c i a t e P r o f e s s o r:E t s u k o T a g a y a A s s o c i a t e P r o f e s s o r:K i y o s h i T a k e y a m a A s s i s t a n t P r o f e s s o r:O s a m i t s u Y a g i I n s t ru c t o r:K e n A r i m u r a I n s t ru c t o r:A y a k o K u b o I n s t ru c t o r:R i e M i z o b u c h i
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MEDICINE Ⅰ(RESPIRATORY)
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About usO u r d e p a r t m e n t i s i n c h a r g e o f h y p e r te n s i o n a n d e n d o c r i n e d i s e a s e s . W e h a v e b e e n g i v i n g o u r s e l v e s 1 ) t o e s t a b l i s h s t r a t e g i e s t o “ c u r e ” h y p e r t e n s i o n , 2 ) t o c r e a t e n o v e l t r e a t m e n t s f o r e n d o c r i n e d i s e a s e s b y u t i l i z i n g e p i g e n e t i c a n a l y s e s , a n d 3 ) t o d i s c o v e r n o v e l h u m o r a l f a c t o r s o r i g i n a t i n g f r o m e n d o c r i n e o r g a n s t o a p p l y i n n o v a t i v e d r u g d e v e l o p m e n t f o r l i f e s t y l e - r e l a t e d d i s e a s e s . O u r u l t i m a t e g o a l i s t o b r i n g u p o u r g r a d u a t e s t u d e n t s t o e x c e l l e n t r e s e a r c h e r s t o w i n N o b e l P r i z e i n P h y s i o l o g y o r M e d i c i n e .
MEDICINE Ⅱ(ENDOCRINOLOGY AND HYPERTENSION)
Research( 1 ) I n v e s t i g a t i o n s o f r o l e s a n d r e g u l a t o r y m e c h a n i s m s o f t h e ( p r o ) r e n i n r e c e p t o r i n e n d o c r i n e a n d e n d o c r i n e - r e l a t e d d i s e a s e s ( I n s t r uc t o r s : A n d o T , M o r i m o t o S , I c h i h a r a A ) ( 2 ) A n a l y s e s o f t h e b l o o d p r e s s ur e c o n t r o l s y s t e m b y t h e d i e n c e p h a l o h y po p h y s i a l r e n i n - a n g i o t e n s i n -a l d o s t e r o n e s y s t e m ( M o r i m o t o S , I c h i h a r a A )( 3 ) M e c h a n i s m a n a l y s e s o f t h e t i s s u e r e n i n - a n g i o t e n s i n s y s t e m d e p e n d e n t o r g a n d a m a g e s b y t h y r o i d d y s f u n c t i o n ( M o r i m o t o S , I c h i h a r a A )( 4 ) E l u c i d a t i o n o f p a t h o p h y s i o l o g i c a l r o l e s o f s t e r o i d h o r m o n e s i n l i f e s t y l e - r e l a t e d d i s e a s e s ( A n d o T , I c h i h a r a A )( 5 ) E l u c i d a t i o n o f t u m o r i g e n e s i s m e c h a n i s m s o f a d r e n a l t u m o r s v i a e c t o p i c r e c e p t o r e x p r e s s i o n s ( W a t a n a b e D , M o r i m o t o S , I c h i h a r a A )( 6 ) E s t a b l i s h m e n t o f a p p r o p r i a t e e v a l u a t i o n c r i t e r i a f o r e n d o c r i n e d i s e a s e s ( Y a t a b e M , M o r i m o t o S , I c h i h a r a A )( 7 ) I n v e s t i g a t i o n s o f r e g u l a t o r y m e c h a n i s m s o f n e u r o h u m o r a l f a c t o r s a n d a n t i - a t h e r o s c l e r o t i c e f f e c t s b y m e d i c a t i o n s f o r l i f e s t y l e - r e l a t e d d i s e a s e s ( M o r i m o t o S , I c h i h a r a A )( 8 ) I n v e s t i g a t i o n s o f p a t h o p h y s i o l o g y o f h y p e r t e n s i o n i n d u c e d b y n e u r o v a s c u l a r c o m p r e s s i o n o f t h e r o s t r a l v e n t r o l a t e r a l m e d u l l a ( M o r i m o t o S , I c h i h a r a A )( 9 ) M e c h a n i s m a n a l y s e s o f t h e b l o o d p r e s s ur e c o n t r o l s y s t e m b y s e x h o r m o n e s ( Y a t a b e J , M o r i m o t o S , I c h i h a r a A )
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FacultyA t s u h i r o I c h i h a r a : p r o f e s s o r , d e p a r tm e n t h e a dO s a m u I s o z a k i : a s s o c i a t e p r o f e s s o rS a t o s h i M o r i m o t o : a s s o c i a t e p r o f e s s o rT a k a s h i A n d o : a s s i s t a n t p r o f e s s o rD a i s u k e W a t a n a b e : r e s e a r c h a s s o c i a t eJ u n i c h i Y a t a b e : r e s e a r c h a s s o c i a t eM i d o r i Y a t a b e : r e s e a r c h a s s o c i a t e
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MEDICINE Ⅱ(ENDOCRINOLOGY AND HYPERTENSION)
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About usT h e D i a b e t e s C e n t e r w a s e s t a b l i s h e d t o p r o v i d e t h e b e s t c o m p r e h e n s i v e a n d u p - t o - d a t e c a r e f o r p a t i e n t s w i t h d i a b e t e s a n d t h e i r f a m i l i e s i n o r d e r t o r e d u c e t h e n u m b e r o f p a t i e n t s a n d f a m i l i e s s u f f e r i n g f r o m d i a b e t e s - r e l a t e d d i s e a s e s .W e p r o v i d e p a t i e n t e d u c a t i o n , m e d i c a l t r e a t m e n t a n d e a r l y d e t e c t i o n a n d i n t e r v e n t i o n s f o r t h e
c o m p l i c a t i o n s r e l a t e d t o d i a b e t e s b a s e d o n t h e l a t e s t r e s e a r c h a n d t r e a t m e n t b y a m u l t i d i s c i p l i n a r y s t a f f t o f a c i l i t a t e t h e b e s t p o s s i b l e o u t c o m e f o r t h e p a t i e n t .W e h a v e a w i d e r a n g e o f p a t i e n t s , t h o s e n e w l y d i a g n o s e d w i t h d i a b e t e s , t h o s e w h o h a v e h a d s o m e d i a b e t e s e d u c a t i o n b e f o r e , t h o s e w h o n e e d s o m e u p - t o - d a t e e d u c a t i o n , a n d t h o s e w i t h a n d w i t h o u t s e v e r e c o m p l i c a t i o n s . W e p r o v i d e e d u c a t i o n a l p r o g r a m s m a i n l y i n t h e i n p a t i e n t u n i t s , b u t a l s o i n t h e o u t p a t i e n t u n i t s a c c o r d i n g t o e a c h p a t i e n t ' s n e e d s .
MEDICINE Ⅲ(D IABETES AND METABOLIC SYNDROME)
Researchh t t p : / / gyo sek i . twmu.a c . j p / twmh p/Kg Ap p?k o za c=N10 00 0 00 00 00 &ye ar=2 0 16
FacultyY a s u k o U c h i g a t a P r o f e s s o r & C h a i r m a nS h i g e h i k o K i t a n o P r o f e s s o rM a i k o S a t o P r o f e s s o rN a o k o I w a s a k i A s s o c i a t e p r o f e s s o rT e t s u y a B a b a z o n o A s s o c i a t e p r o f e s s o rT o m o k o N a k a g a m i A s s o c i a t e p r o f e s s o rM a k i k o O g a t a L e c t u re rR e i k a Y a n a g i s a w a L e c t u r e rJ y u n n o s u k e M i u r a L e c t u r e r
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About usI n 1 9 7 9 , K i d n e y c e n t e r w a s e s t a b l i s h e d i n T o k y o w o m e n ’ s m e d i c a l u n i v e r s i t y , a n d t h e d e p a r tm e n t o f m e d i c i n e ( n e p h r o l o g y ) w a s a l s o e s t a b l i s h e d a s a c l i n i c a l d e p a r t m e n t i n t h a t K i d n e y C e n t e r a t t h a t t i m e .I n 1 9 8 3 , t h e d e p a r t m e n t m e d i c i n e I V w a s e s t a b l i s h e d a s t h e c h a i r . U n d e r t h e g u i d a n c e o f p r o f e s s o r K o s a k u N i t t a , a b o u t 9 0 d o c t o r s o f t h e m e m b e r o f d e p a r t m e n t o f m e d i c i n e I V m a k e a n e f f o r t o n t h e c l i n i c a l s i t e , r e s e a r c h , a n d e d u c a t i o n e v e r y d a y .O u r c l i n i c a l p o l i c y i s t o g i v e t h e f i r s t p r i o r i t y t o o u r p a t i e n t s . C h r o n i c k i d n e y d i s e a s e i s n o t s h o r t t e r m
d i s e a s e , t h e n w e m u s t h e l p a n d c o o p e r a t e o u r C K D p a t i e n t s f o r a l o n g t i m e . W i t h o u t c o n s i d e r i n g a d i s e a s e a l o n e , w e a l w a y s t a k e c a r e o f o u r C K D p a t i e n t s w i t h c o n s i d e r i n g p a t i e n t ’ s m i n d s a n d s o c i a l b a c k g r o u n d s . T h a t ’ s o u r m o s t i m p o r ta n t p o i n t . T h e r e f o r e , w e h a v e c o n s i d e r e d t h a t o u r a i m o f r e s e a r c h i s t o a n a l y z e t h e q u e s t i o n s f r o m p a t i e n t s i n a c t u a l c l i n i c a l s e t t i n g s a n d t o r e t u r n t h e a n s w e r s a n d r e s u l t s t o t h e p a t i e n t s . T h e s e n i o r r e s i d e n t s m a k e a n e f f o r t o n c l i n i c a l a n d / o r b a s i c r e s e a r c h , b e c a u s e w e r e c o g n i z e t h a t t o t a k e P h . D . ( D o c t o r o f P h i l o s o ph y ) i s t h e s t a r t t o b e c o m e a r e a l d o c t o r . W e p e r f o r m t h e c l i n i c a l r e s e a r c h b a s e d o n a l o t o f c l i n i c a l a n d p a t h o l o g i c a l d a t a , a n d a l s o p e r f o r m t h e b a s i c r e s e a r c h w i t h a n i m a l d i s e a s e m o d e l s , p a t i e n t ’ s g e n e t i c i n f o r m a t i o n , a n d r e g e n e r a t i v e m e d i c i n e t o r e c o g n i z e d e e p l y t h e p a t h o p h y s i o l o g y .
MEDICINE Ⅳ(NEPHROLOGY)
Research① C h r o n i c G l o m e r u l o n e p h r i t i s ( C G N ) : R i t u x i m a b t r e a t m e n t f o r n e p h r o t i c s y n d r o m e ( N S ) . P r o g n o s i s , t r e a t m e n t , a n d r i s k f a c t o r s o f I g A n e p h r o p a t h y , l u p us n e p h r i t i s a n d A N C A r e l a t e d n e p h r i t i s .② C h r o n i c K i d n e y D i s e a s e ( C K D ) : A n a l y s i s o f m i n e r a l a n d b o n e d i s o r de r ( M B D ) , v a s c u l a r c a l c i f i c a t i o n ( V C ) a n d r i s k f a c t o r s i n C K D p a t i e n t s .③ A u t o s o m a l d o m i n a n t p o l y c y s t i c k i d n e y d i s e a s e ( A D P K D ) : G e n e t i c a n a l y s i s . T o l v a p t a n t r e a t m e n t . Q u a l i t y o f l i f e i n A D P K D p a t i e n t s w i t h p o l y c y s t i c l i v e r .④ H e m o di a l y s i s ( H D ) : A n a l y s i s o f m i n e r a l a n d b o n e d i s o r d e r , v a s c u l a r c a l c i f i c a t i o n a n d a n e m i a i n H D p a t i e n t s
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FacultyK o s a k u N i t t a ( P r o f e s s o r , C h a i r m a n ) K e n T s u c h i y a ( P r o f e s s o r , D e p a r t m e n t o f B l o o d P u r i f i c a t i o n )K e i k o U c h i d a ( P r o f e s s o r , S t u de n t h e a l t h c a r e c e n t e r )T o s h i o M o c h i z uk i ( P r o f e s s o r , C l i n i c a l r e s e a r c h d i v i s i o n f o r p o l y c y s t i c k i d n e y d i s e a s e )T a k a h i t o M o r i y a m a ( A s s o c i a t e P r o f e s s o r )M i t s u y o I t a b a s h i ( A s s i s t a n t P r o f e s s o r )
publication
MEDICINE Ⅳ(NEPHROLOGY)
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About usU n d e r C o n s t r u c t i o n
CARDIOLOGY
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
publication
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About usD i g e s t i v e i n t e r n a l m e d i c i n e i s t a r g e t e d t o m a n y o r g a n s , i n c l u d i n g t h e l i v e r , g a l l b l a d de r , p a n c r e a s a n d g a s t r o i n t e s t i n a l t r a c t ( e s o p h a g u s , s t o m a c h , d u o d e n u m , s m a l l i n t e s t i n e , l a r g e i n t e s t i n e ) . T h e t a r g e t d i s e a s e s a r e v a r i o u s , c o n s i s t i n g p a r t i c u l a r l y o f h i g h i n c i d e n c e s o f g a s t r i c c a n c e r , c o l o r e c t a l c a n c e r , l i v e r c a n c e r , a n d p a n c r e a t i c c a n c e r . E a r l y d e t e c t i o n o f t h e s e d i s e a s e s i s d i f f i c u l t . T h e r e a r e m a n y r e s e a r c h c h a l l e n g e s , a n d t h e m i s s i o n o f o u r D e p a r tm e n t i s t o i d e n t i f y t h e p a t h o g e n e s i s o f t h e s e d i s e a s e s , a n d d e f i n e e a r l y d i a g n o s i s a n d t r e a t m e n t . W e c o o p e r a t e w i t h t h e D e p a r t m e n t , a s w e l l a s b o t h i n s i d e a n d o u t s i d e t h e b a s i c r e s e a r c h g r o u p s a n d f a c i l i t i e s . W e a r e l o o k i n g f o r y o u n g r e s e a r c h e r s f o r d i g e s t i v e s c i e n c e .
GASTROENTEROLOGY
Research( 1 ) H e m o d y n a m i c s a n d t h e r a p y o f g a s t r i c a n d e s o p h a g e a l v a r i x( 2 ) T h e r a p y o f v i r u s h e p a t i t i s , ( 3 ) I m p r o v e m e n t o f l o n g s u r v i v a l i n t h e p a t i e n t s w i t h l i v e r t r a n s p l a n t a t i o n( 4 ) H e p a t o c a r c i n o g e n e s i s f r o m N A S H , ( 5 ) G e n o m i c b a c k g r o u n d i n l i v e r d i s e a s e s ,( 6 ) B a s i c a n d c l i n i c a l r e s e a r c h o f a u t o i m m u n e p a n c r e a t i t i s( 7 ) E a r l y d e t e c t i o n o f p a n c r e a t i c t u m o r( 8 ) R e g e n e r a t i o n o f c o l o n e p i t h e l i a l c e l l FacultyP r o f e s s o r ; K a t s u to s h i T o k u s h i g e M D S e n i o r l e c t u re ; M a i k o T a n i a i M D
E t s u k o H a s h i m o t o M D N o b u y uk i T o r i i M DS h i n i c h i N a k a m u r a M D B u n e i I i z u k a M DK y o k o S h i m i z u M D T o m o m i K o g i s o M D
Y u k i k o T a k a y a m a M D publication
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About usO u r g o a l o f t h e b a s i n a n d c l i n i c a l s t u d y i s t o c l a r i f y t h e p a t h o p h y s i o l o g y a n d d e v e l o p t h e n o v e l t h e r a p e u t i c s t r a t e g y f o r n e u r o l o g i c a l d i s e a s e . W e c o v e r w i d e r a n g e o f n e u r o l o g i c a l d i s e a s e i n c l u d i n g s t r o k e , p a r k i n s o n - r e l a t e d d i s e a s e , n e u r o - i n f l a m m a t o r y d i s e a s e , d e m e n t i a a n d p e r i ph e r a l n e r v e a n d m u s c l e d i s e a s e . W e e m p l o y s e v e r a l c l i n i c a l e x a m i n a t i o n s u c h a s M R I / C T , S P E C T , u l t r a s o u n d , M E P / S E P , N C V / E M G a n d E E G . W e p u b l i s h m a n y o r i g i n a l a r t i c l e s c o v e r i n g w i d e a r e a o f n e u r o l o g y i n p e e r - r e v i e w j o u r n a l s . M a n y c l i n i c a l s t u d i e s a r e n o w o n g o i n g t o g e t h e r w i t h b a s i c e x p e r i m e n t a l s t u d i e s f o r s t r o k e . W e w e l c o m e a l l r e s e a r c h e r s i n t e r e s t e d i n n e u r o l o g y .
NEUROLOGY
Research1 . E x p e r i m e n t a l s t u d i e s f o r i s c h e m i c t o l e r a n c e a n d r e m o t e i s c h e m i c c o n d i t i o n i n g f o r b r a i n p r o t e c t i o n2 . C l i n i c a l s t u d i e s f o r E S U S ( e m b o l i c s t r o k e o f u n d e t e r m i n e d s o u r c e )3 . P a t h o p h y s i o l o g y f o r n e u r o - i n f l a m m a t o r y d i s e a s e ( M S / N MO )4 . G a i t d i s t u r b a n c e a n a l y s i s f o r P a r k i n s o n - r e l a t e d d i s e a s e5 . N e u r o p s y c h o l o g i c a l a n a l y s i s f o r d e m e n t i a p a t i e n t s6 . N e u r o i m a g i n g ( S P E C T , D A T , M I B G ) f o r n e u r o d e g e n e r a t i v e d i s e a s e 7 . P a t h o p h y s i o l o g y f o r C I D P / M MN u s i n g s a m p l e s i n p e r i p h e r a l n e r v e a n d m u s c l e b i o p s y
FacultyP r o f e s s o r a n d C h a i r m a n ; K a z u o K i t a g a w aA s s o c i a t e P r o f e s s o r ; Y u k o S h i m i z u , M u t s u m i I i j i m aL e c t u r e r ; H i r o s h i Y o s h i z a w a
publication
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About usO u r g o a l o f t h e b a s i n a n d c l i n i c a l s t u d y i s t o c l a r i f y t h e p a t h o p h y s i o l o g y a n d d e v e l o p t h e n o v e l t h e r a p e u t i c s t r a t e g y f o r n e u r o l o g i c a l d i s e a s e . W e c o v e r w i d e r a n g e o f n e u r o l o g i c a l d i s e a s e i n c l u d i n g s t r o k e , p a r k i n s o n - r e l a t e d d i s e a s e , n e u r o - i n f l a m m a t o r y d i s e a s e , d e m e n t i a a n d p e r i ph e r a l n e r v e a n d m u s c l e d i s e a s e . W e e m p l o y s e v e r a l c l i n i c a l e x a m i n a t i o n s u c h a s M R I / C T , S P E C T , u l t r a s o u n d , M E P / S E P , N C V / E M G a n d E E G . W e p u b l i s h m a n y o r i g i n a l a r t i c l e s c o v e r i n g w i d e a r e a o f n e u r o l o g y i n p e e r - r e v i e w j o u r n a l s . M a n y c l i n i c a l s t u d i e s a r e n o w o n g o i n g t o g e t h e r w i t h b a s i c e x p e r i m e n t a l s t u d i e s f o r s t r o k e . W e w e l c o m e a l l r e s e a r c h e r s i n t e r e s t e d i n n e u r o l o g y .
HEMATOLOGY
Research( 1 ) R o l e o f N K c e l l s o n h e m a t o p o i e t i c s t e m c e l l t r a n s p l a n t a t i o n( 2 ) A n a l y s i s o f i m u n n e r e s p o n s e a f t e r h e m a t o p o i e t i c s t e m c e l l t r a n s p l a n t a t i o n( 3 ) A n a l y s i s o f i m u n n e r e s p o n s e d u r i n g t r e a t m e n t o f h e m a t o l o g i c a l d i s e a s e s( 4 ) D e v e l o p m e n t o f n e w c e l l t h e r a p i e s f o r h e m a t o l o g i c a l d i s e a s e s( 5 ) A n a l y s i s o f g e n e m u t a t i o n s o f h e m a t o l o g i c a l d i s e a s e s( 6 ) A n a l y s i s o f m o l e c u l a r m e c h a n i s um s o f m y e l o d y s p l a s t i c s y n d r o m e ( M D S )( 7 ) P r o g n o s t i c f a c t o r s o f m a l i g n a n t l y m p h o m a
FacultyJ u n j i T a n a k a , M D , P h D . P r o f e s s o r & C h a i r m a nN a o k i M o r i , M D , P h D . A s s o c i a t e p r o f e s s o rM a s a y uk i S h i s e k i , M D , P h D . A s s o c i a t e p r o f e s s o rK e n t a r o u Y o s h i n a g a , M D , P h D . L e c t u re r publication
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About usP s y c h i a t r y , a b r a n c h o f c l i n i c a l m e d i c i n e , d e a l s w i t h a w i d e r a n g e o f h u m a n b e h a v i o r , f r o m v a r i o u s m e n t a l d i s o r de r s t o m e n t a l h e a l t h a m o n g h e a l t h y p e o p l e . T h e r a n g e o f m e t h o d o l o g i e s u s e d i n p s y c h i a t r y i n c l u d e t r a d i t i o n a l m e t h o d s s u c h a s p h y s i o l o g y , b i o c h e m i s t r y , p h a r m a c o l o g y , a s w e l l a s p u b l i c h e a l t h , h u m a n i s t i c m e t h o d s s u c h a s p s y c h o l o g y , a s w e l l a s c o g n i t i v e b e h a v i o r a l s c i e n c e a n d c o m p u t a t i o n a l a n a l y s i s . I n t h e 2 1 s t c e n t u ry , m e n t a l d i s o r d e r s i m p o s e a s u b s t a n t i a l d i s e a s e b u r d e n o n s o c i e t i e s a r o u n d t h e w o r l d . R e s e a r c h e r s f a c e i n c r e a s i n g c h a l l e n g e s i n e l u c i d a t i n g t h e p a t h o p h y s i o l o g y o f m e n t a l d i s o r d e r s a n d d e v e l o p i n g a p p r o p r i a t e t r e a t m e n t m e t h o d s . T h u s , p s y c h i a t r y i s a n e x c i t i n g f i e l d o f s c i e n t i f i c r e s e a r c h t h a t p r o m i s e s a n a c a d e m i c s e n s e o f f u l f i l m e n t a n d a s e n s e o f a c c o m p l i s h m e n t f o r a m b i t i o u s s t u de n t s .
PSYCHIATRY
Research1 ) B a s i c p s y c h o p h a r m a c o l o g yU n d e r s t a n d i n g t h e m e c h a n i s m s o f p s y c h i a t r i c d i s o r d e r s a n d p s y c h o t ro p i c d r u g s i s i m p o r ta n t f o r d e v e l o p i n g p r o t o c o l s f o r a p p r o p r i a t e u s e . T h u s , o u r l a b o r a t o r y u n d e r t a k e s b a s i c p s y c h o p h a r m a c o l o g y r e s e a r c h w i t h o w n e x p e r i m e n t a l f a c i l i t y . O u r m a i n r e s e a r c h t h e m e s a r e s t r e s s , m e m o r y , v u l n e r a b i l i t y a n d r e s i l i e n c e . O u r r e s e a r c h s e e k s t o o p t i m i z e p h a r m a c o l o g i c a l t h e r a p y .
C l i n i c a l p s y c h o p h a r m a c o l o g y2 ) T h i s i s a f i e l d o f r e s e a r c h f o c u s e d o n i n f o r m i n g r a t i o n a l j u d g m e n t s a b o u t p h a r m a c o t h e r a p y f o r p s y c h i a t r i s t s i n g e n e r a l c l i n i c a l s e t t i n g s . B y a d v a n c i n g t h i s a r e a o f s t u d y , w e s e e k t o u p d a t e a n d s t a n d a r d i z e t h e w a y p s y c h o t r o p i c d r u g s a r e u s e d i n d a i l y m e d i c a l p r a c t i c e . W e e n g a g e i n s e v e r a l s p e c i f i c p r o j e c t s , i n c l u d i n g t h e i n v e s t i g a t i o n o f f a c t o r s t h a t p r e d i c t c l i n i c a l r e s p o n s e s o r s i d e e f f e c t s o f p h a r m a c o t h e r a p y , v e r i f y i n g t h e v a l i d i t y o f r a t i n g s c a l e s i n s o m e p s y c h i a t r i c i l l n e s s e s , a n d c a r r y i n g o u t c l i n i c a l t r i a l s o f p s y c h o a c t i v e d r u g s b e f o r e m a r k e t i n g .
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PSYCHIATRY
3 ) C l i n i c a l r e s e a r c h i n c o n s u l t a t i o n - l i a i s o n p s y c h i a t r y i n c l u d i n g p a l l i a t i v e c a r eW e h a v e t r a d i t i o n a l l y e m p h a s i z e d c o n s u l t a t i o n - l i a i s o n p s y c h i a t r y . I n c o l l a b o r a t i o n w i t h v a r i o u s m e d i c a l d e p a r tm e n t s , w e a r e c o n d u c t i n g a c t i v e c l i n i c a l r e s e a r c h i n t h e f o l l o w i n g f i e l d s : o r g a n t r a n s p l a n t a t i o n ( k i d n e y , l i v e r a n d h e a r t ) , r h e u m a t i c d i s e a s e s ( s y s t e m i c l u p u s e r y t h e m a t o s us ) , h e a r t d i s e a s e s , a n d d e l i r i u m . I n a d d i t i o n , a s m e m b e r s o f t h e p a l l i a t i v e c a r e t e a m f o r p a t i e n t s w i t h c a n c e r , w e a l s o c o n d u c t m u l t i d i s c i p l i n a r y r e s e a r c h .
FacultyK a t s u j i N i s h i m u r a , M D , P h DP r o f e s s o r a n d c h a i r m a nC o n s u l t a t i o n - l i a i s o n p s y c h i a t r y
H i t o s h i T a k a h a s h i , M D , P h DL e c t u r e r C l i n i c a l p s y c h o p h a r m a c o l o g y
K e n I n a d a , M D , P h DL e c t u r e rB a s i c a n d c l i n i c a l p s y c h o p h a r m a c o l o g y
publication
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About usW e o f t e n f e e l t h a t t h e k e y t o t h e s u c c e s s f u l m a n a g e m e n t o f a d i s e a s e o f u n k n o w n p a t h o g e n e s i s i n o u r f i e l d o f s p e c i a l i z a t i o n i s a l w a y s h i d d e n i n s o m e u n f a m i l i a r f i e l d . T h e s l o g a n o f o u r d e p a r tm e n t i s ‘ F r o m i n c u r a b l e t o c u r a b l e ’ . A r e y o u s a t i s f i e d w i t h t h e p r e s e n t s t a n d a r d t r e a t m e n t o f i n t r a c ta b l e d i s e a s e s a s s o c i a t e d w i t h c h r o m o s o m a l a n o m a l y o r c e r e b ra l p a l s y ? I f y o u r a n s w e r i s ‘ N o ’ , t h e n p l e a s e j o i n u s t o i n v e s t i g a t e n e w s t r a t e g i e s f o r t h e s e i n c u r a b l e d i s e a s e s . W e a r e c u r r e n t l y t r y i n g t o f i n d n e w w a y s t o u t i l i z e r e g e n e r a t i v e m e d i c i n e i n o r d e r t o b e a b l e t o e f f e c t i v e l y t r e a t t h o s e d i s e a s e s .
PEDIATRICS
Research1 . S t u d y t o e l u c i d a t e t h e p a t h o g e n e s i s o f K a w a s a k i D i s e a s e ( D r . N a g a t a )I n o u r p r e v i o us s t u d y , w e f o u n d c e r t a i n m i c r o b e s t h a t p r o d u c e h e a t - s h o c k p r o t e i n 6 0 a n d w h i c h h a v e s u p e r a n t i g e n i c - l i k e p r o p e r t i e s o n t h e s u r f a c e o f t h e p h a r y n g e a l a n d up p e r g a s t r o i n t e s t i n a l t r a c t m u c o s a , w h i c h m i g h t p l a y a r o l e i n t h e o n s e t o f K a w a s a k i d i s e a s e . W e w i l l p e r f o r m f u r t h e r i n v e s t i g a t i o n s o n t h e s e m i c r o b e s i n t h i s p r o j e c t .
2 . I n v e s t i g a t i o n o f v a g i n a l b a c t e r i a l f l o r a c a u s i n g p r e m a t u r e d e l i v e r y . ( D r . N a g a t a )W e r e c e n t l y d e v e l o p e d n o v e l p r o b e s t o s e a r c h f o r m i c r o b e s i n t h e v a g i n a l b a c t e r i a l f l o r a t h a t m a y c a u s e p r e m a t u r e d e l i v e r y . W e w i l l a t t e m p t t o r e g u l a t e t h e s e m i c r o b e s t o p r o t e c t p a t i e n t s f r o m p r e m a t ur e d e l i v e r y d u e t o b a c t e r i a l v a g i n o s i s .
3 . E f f e c t i v e n e s s o f p r o b i o t i c s f o r m a i n t a i n i n g r e m i s s i o n o f i n f l a m m a t o r y b o w e l d i s e a s e s . ( D r N a g a t a )W e w i l l d e m o n s t ra t e t h a t a p r o b i o t i c s t r a i n c a n c o n t r i b u te t o m a i n t a i n i n g t h e r e m i s s i o n o f i n f l a m m a t o r y b o w e l d i s e a s e s i n a c l i n i c a l t r i a l . T h i s h a s p r e v i o u s l y b e e n r e p o r t e d i n a n i m a l m o d e l s
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PEDIATRICS
4 . A u d i o v i s u a l c o g n i t i v e d e v e l o p m e n t a n d i t s d i s o r de r s i n f u l l t e r m n e o n t a t e s a n d p r e m a t u r e l y b o r n b a b i e s . ( D r . H i r a s a w a )T h e s u r v i v a l r a t e o f v e r y l o w b i r t h w e i g h t b a b i e s a r e d e c r e a s i n g w i t h t h e p r o g r e s s o f t h e n e o n a t a l m e d i c i n e . B u t t h e o c c u r re n c e o f t h e d e v e l o p m e n t a l d i s o r d e r s i n p r e m a t ur e l y b o r n b a b i e s . S o i t s e e m s t o b e n e c e s s a r y t o s t u d y t h e a u d i o v i s u a l d e v e l o p m e n t i n e a r l y i n f a n c y i n t h e s e b a b i e s a n d f u l l t e r m b a b i e s u s i n g t h e n e w t e c h n o l o g y s u c h a s g a z e d e t e c t o r s .
5 . D e v e l o p m e n t a l t r a j e c t o r y o f v e r y l o w b i r t h w e i g h t b a b i e s w i t h a u t i s t i c t r a i t a n d i n t e r v e n t i o n ( D r . H i r a s a w a )I t i s b e c o m i n g a p r o b l e m t h a t t h e o c c u r r e n c e r a t e o f a u t i s m s p e c t r u m d i s o r de r s i n p r e m a t ur i t y b o r n b a b i e s i s i n c r e a s i n g . I t s e e m s t o b e i n t e r e s t i n g t o i n v e s t i g a t e t h e d e v e l o p m e n t a l t r a j e c t o r y o f t h e p r e m a t u r e l y b o r n b a b i e s w i t h a u t i s t i c t r a i t f r o m a v a s t f o l l o w - u p d a t a i n o u r N I C U g r a d u a t e s A n d a n a l y z i n g s u c h d a t a , w e w o u l d l i k e t o s u g g e s t t h e e f f i c i e n t p r o c e d ur e s o f d e v e l o p m e n t a l i n t e r v e n t i o n .
6 . N e u r o p h y s i o l o g i c a l s t u d y o f m y o c l o n i c s e i z u r e s a n d e p i l e p t i c s p a s m s ( D r . O g u n i )I n o r d e r t o i n v e s t i g a t e t h e u n d e r l y i n g n e u r o p h y s i o l o g i c a l m e c h a n i s m o f m y o c l o n i c s e i z u r e s a n d e p i l e p t i c s p a s m s , w e s t u d y o n i c t a l p o l y g r a p h s o f t h e s e s e i z u re s b y m e a n s o f c o m p u t e r - b a s e d E E G a n a l y s i s t o m e a s u r e t h e l a t e n c y b e t w e e n v a r i o u s E E G c o m p o n e n t s o f e p i l e p t i c E E G s e i z u r e s a n d t h e o n s e t o f E M G m a n i f e s t a t i o n , a n d a l s o h i g h - f r e q u e n c y o s c i l l a t i o n i n t h e e p i l e p t i c E E G s e i z u re s .
7 . T r a n s l a t i o n a l r e s e a r c h f o r p e d i a t r i c m a l i g n a n t t u m o r . ( T r a n s l a t i o n a l r e s e a r c h ) A v a i l a b l e a l s o e x c e p t a m e d i c a l d o c t o r . ( D r . T s u r u t a )T o l e a r n t h e t r a n s l a t i o n a l r e s e a r c h ( m e d i a t i o n r e s e a r c h f r o m b a s i c t o c l i n i c a l ) a b o u t t h e t r e a t m e n t o f a c h i l d h o o d c a n c e r , f o r e x a m p l e , t h e m o l e c u l a r t a r g e t e d t h e r a p i e s , t h e c a n c e r p e p t i d e v a c c i n e s , t h e c h i m e r i c a n t i g e n r e c e p t o r T - c e l l t h e r a p i e s , t h e i n h i b i t o r s o f r e g u l a t o r y T - c e l l , t h e i m m u n e c h e c k p o i n t i n h i b i t o r s , o r t h e o n c o l y t i c v i r u s e s . E s p e c i a l l y , t o l e a r n t h e p r o c e s s t o h o w t o m a k e t h e p l a n o f a b a s i c e x p e r i m e n t , t o m a k e t h e p r o t o c o l o f a c l i n i c a l t r i a l , t o t a k e d a t a , a n d t o m a k e r e c o g n i t i o n o f t h e p h a r m a c e ut i c a l a f f a i r s , e t c .
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PEDIATRICS
8 . D e v e l o p m e n t o f n e w d r u g s f o r p e d i a t r i c m a l i g n a n t t u m o r ( I n v e s t i g a t o r i n i t i a t e d c l i n i c a l t r i a l ) . ( D r . T s u r u t a )T o l e a r n t h e t r a n s l a t i o n a l r e s e a r c h ( m e d i a t i o n r e s e a r c h f r o m b a s i c t o c l i n i c a l ) a b o u t t h e t r e a t m e n t o f a c h i l d h o o d c a n c e r , f o r e x a m p l e , t h e m o l e c u l a r t a r g e t e d t h e r a p i e s , t h e c a n c e r p e p t i d e v a c c i n e s , t h e c h i m e r i c a n t i g e n r e c e p t o r T - c e l l t h e r a p i e s , t h e i n h i b i t o r s o f r e g u l a t o r y T - c e l l , t h e i m m u n e c h e c k p o i n t i n h i b i t o r s , o r t h e o n c o l y t i c v i r u s e s , t h a t a r e a p p l i e d t o t h e a d u l t , b u t c h i l d r e n .
9 . T r i a l o f n e w t h e r a p y f o r t h e i n t r a c t a b l e h e m a t o p o i e t i c d i s e a s e s . ( D r . T s u r u t a )T o l e a r n a p r o c c e s s o f d e v e l o p m e n t o f t h e n e w t h e r a p y f o r s u c h a s t h e i n t r a c t a b l e h e m o l y t i c a n e m i a , b y u s i n g t h e t e c h n i q u e o f m o l e c u l a r t h e r a p y o r c e l l u l a r t h e r a p y , s u c h a s a g e n e t h e r a p y o r a h e m a t o p o i e t i c - s te m - c e l l - t ra n s p l a n t a t i o n .
1 0 . C l i n i c a l o r b a s i c r e s e a r c h f o r i n c u r a b l e n e u r o g e n i c o r m u s c u l a r d i s e a s e s b y t h e t i s s u e s t e m c e l l s . ( D r . T s u r u t a )A v a i l a b l e a l s o e x c e p t a m e d i c a l d o c t o r .T o l e a r n t h e c l i n i c a l o r b a s i c r e s e a r c h o f t h e r e g e n e r a t i o n m e d i c i n e w h i c h u s e d t i s s u e s t e m c e l l s , s u c h
a s a m e s e n c h y m a l s t e m c e l l , f o r v a r i o u s i n c u r a b l e d i s e a s e s , s u c h a s n e u r o g e n i c d i s e a s e s , m u s c u l a r d i s e a s e s o r m e t a b o l i s m d i s e a s e s .
1 1 . A p p r o a c h t o d e v e l o p i n g a n e w t r e a t m e n t f o r F u k u y a m a c o n g e n i t a l m u s c u l a r d y s t ro p h y ( D r . I s h i g a k i )O u r e m e r i t us p r o f e s s o r , D r . F u k u y a m a , r e p o r t e d t h e f i r s t p a t i e n t w i t h F u k u y a m a c o n g e n i t a l m u s c u l a r d y s t r o p h y ( F C M D ) i n o u r d e p a r t m e n t . S i n c e r e p o r t s o f F C M D p a t i e n t s a r e l o c a l i z e d w i t h i n J a p a n , o n l y a f e w i n s t i t u te s a r e w o r k i n g t o d e v e l o p a t r e a t m e n t f o r t h i s d i s e a s e , i n c o n t r a s t t o t h e e x t e n s i v e r e s e a r c h b e i n g c o n d u c t e d o n D u c h e n n e m u s c u l a r d y s t r o p h y . W e a r e p l a n n i n g ( i ) t o i d e n t i f y n e w f a c t o r s c a u s i n g n e c r o s i s o r e x a c e r b a t i n g F C M D i n o r d e r t o d i s c o v e r n e w m e t h o d s o f t r e a t m e n t a n d ( i i ) t o d e v e l o p r e g e n e r a t i v e m e d i c i n e t e c h n i q u e s e m p l o y i n g s t e m c e l l s w i t h D r . T s u r u t a ’ s ( A s s o c i a t e p r o f e s s o r ) g r o u p .
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PEDIATRICS
1 2 . S t e r o i d t h e r a p y f o r p a t i e n t s w i t h F C M D ( D r . I s h i g a k i )S t e r o i d t h e r a p y i s n o w p a r t o f t h e c a r e r e c o m m e n da t i o n s f o r D u c h e n n e m u s c u l a r d y s t ro p h y a n d i s i n w i d e s p r e a d r o u t i n e u s e . T h e e v i d e n c e t h a t s h o r t - t e r m s t e r o i d a d m i n i s t r a t i o n i s a l s o e f f e c t i v e f o r a g g r a v a t i o n o f m u s c l e w e a k n e s s a f t e r i n f e c t i o n s i n F C M D p a t i e n t s s u p po r t s t h e p o s s i b l e e f f i c a c y o f t h i s t h e r a p y f o r F C M D p a t i e n t s , b u t o n l y a f e w c a s e s h a v e b e e n r e p o r te d t o d a t e . W e a r e p l a n n i n g a p r o s pe c t i v e s t u d y t o a s s e s s t h e e f f i c a c y o f l o n g - t e r m s t e r o i d t h e r a p y f o r p a t i e n t s w i t h F C M D .
1 3 . A n o v e l m e a s u r e o f f u n c t i o n f o r F C M D ( D r . I s h i g a k i )W i t h i n a f e w y e a r s , w e m i g h t b e a b l e t o l a u n c h a c l i n i c a l t r i a l f o r F C M D p a t i e n t s . T o a s s e s s t h e e f f i c a c y o f a n y n e w m e d i c a t i o n , w e n e e d a s t a b l e a n d h i g h l y r e l i a b l e m e a s u r e t h a t a c c u r a t e l y r e f l e c t s f u n c t i o n i n F C M D p a t i e n t s . W e a r e p l a n n i n g t o e v a l u a t e a c t i n o g r a p h y a s a p r o m i s i n g t o o l f o r f u n c t i o n m e a s u r e m e n t i n F C M D p a t i e n t s .
FacultyS a t o r u N a g a t a , M D , P h D . P r o f e s s o r a n d C h a i r m a n o f t h e d e p a r tm e n t , D i r e c t o r o f C h i l d r e n ’ s M e d i c a l C e n t e rH i r o k a z u O g u n i , M D , P h D . P r o f e s s o r K y o k o H i r a s a w a , M D , P h D . A s s o c i a t e P r o f e s s o rT o s h i h i s a T s u r u t a , M D , P h D . A s s o c i a t e P r o f e s s o rK e i k o I s h i g a k i , M D , P h D . A s s i s t a n t P r o f e s s o rA k i k o T a k e s h i t a , M D , P h D . R e s e a r c h A s s o c i a t eM i y u k i S a k a k i b a r a , M S . C l i n i c a l P s y c h o l o g i s tS a t o s h i K u s u da , M D , P h D . P r o f e s s o r o f N e o n a t a l M e d i c i n e
publication
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About usD e r m a t o l o g y i s a m e d i c a l s c i e n c e w h i c h d e a l s w i t h t h e s k i n , t h e l a r g e s t o r g a n o f h u m a n b o d y . I t c o v e r s a w i d e r a n g e o f d i s e a s e s i n c l u d i n g a l l e r g i c , i n f l a m m a t o r y , i n f e c t i o u s a n d h e r e d i t a r y d i s e a s e s , a n d b e n i g n a n d m a l i g n a n t t u m o r s . I n a d d i t i o n t o c l i n i c a l a s p e c t , b a s i c a n d c l i n i c a l r e s e a r c h i s a l s o i m p o r ta n t a n d a t t r a c t i v e , s i n c e s k i n s y m p t o m i s v i s i b l e a n d a c c e s s i b l e , t h e r e f o r e , i t i s l e s s i n v a s i v e t o o b t a i n t h e s p e c i m e n s . T h i s i s a g r e a t a d v a n t a g e t o d e r m a t o l o g y .
DERMATOLOGY
Research( 1 ) T h e e f f e c t o f N e a r - i n f r a r e d R a d i a t i o n o n t h e s k i n a n d s e b o c y t e s( 2 ) T h e p a t h o g e n e t i c r o l e o f b a c t e r i a i n c l u d i n g F u s o b a c t e r i a i n t h e p a t i e n t s w i t h f a c i a l d e r m a t i t i s( 3 ) C h e m o k i n e s a n d c y t o k i n e s i n a t o p i c d e r m a t i t i s
FacultyM a k o t o K a w a s h i m a , M . D . , P h . D . , P r o f e s s o rN a o k o I s h i g u ro , M . D . , P h . D . , A s s o c i a t e P r o f e s s o rY u i c h i r o T s u n e m i , M . D . , P h . D . , A s s o c i a t e P r o f e s s o r
publication
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About us R a d i a t i o n o n c o l o g y i s a f i e l d f o r c a n c e r t r e a t m e n t w i t h r a d i a t i o n . I t b a s e d o n c l i n i c a l o n c o l o g y ,
r a d i a t i o n b i o l o g y , a n d m e d i c a l p h y s i c s . C a n c e r i s t h e m a i n c a u s e o f d e a t h a m o n g J a p a n e s e a n d i t w i l l b e i n c r e a s i n g w i t h a d v a n c e m e n t o f
a g i n g s o c i e t y . S o w e s h o u l d o v e r c o m e c a n c e r b y h i g h p r e c i s i o n r a d i o t h e r a p y w i t h l e s s e r b u r d e n t o e l d e r l y p a t i e n t s .
R e c e n t t e c h n o l o g i c a l d e v e l o p m e n t , r a d i o t h e r a p y e n a b l e s t o i r r a d i a t e t u m o r s p r e c i s e l y w i t h o u t h i g h d o s e a r e a o f n o r m a l t i s s u e . I n t e n s i t y m o d u l a t e d r a d i a t i o n t h e r a p y ( I M R T ) , s t e r e o t a c t i c i r r a d i a t i o n ( S T I ) , i m a g e - g u i d e d r a d i a t i o n t h e r a py ( I G R T ) a n d p a r t i c l e t h e r a p y a r e t h e e x a m p l e o f r e c e n t a d v a n c e m e n t .
T o p r o v i d e t h e b e s t m e d i c a l c a r e i s t h e s p i r i t o f t h e u n i v e r s i t y ' s f o u n d i n g . O u r d e p a r t m e n t h a s m o r e t h a n 7 0 y e a r s h i s t o r y o f r a d i a t i o n o n c o l o g y r e s e a r c h , P r o f e s s o r T a s a k i , o u r s e c o n d c h i e f p r o f e s s o r , w a s t h e f i r s t p r e s i d e n t o f J a p a n e s e S o c i e t y o f R a d i a t i o n O n c o l o g y ( J A S T R O ) , a n d t h e f i r s t a n n u a l m e e t i n g o f J A S T R O w a s h e l d a t Y a y o i M e m o r i a l H a l l o f o u r u n i v e r s i t y i n 1 9 8 9 , l a r g e n u m b e r o f c l i n i c a l d a t a h a s b e e n a c c u m u l a t e d f o r c l i n i c a l s t u d y .
T h e a i m o f o u r d e p a r tm e n t i s t r a i n i n g o f e x c e l l e n t r e s e a r c h e r s , c l i n i c i a n s a n d e d u c a t o r s . O u r d e p a r tm e n t h a s a d i v i s i o n o f c l i n i c a l r a d i a t i o n o n c o l o g y a n d a m e d i c a l p h y s i c s . A n d a l s o h a v e a s t r o n g j o i n t r e s e a r c h s y s t e m w i t h r e s e a r c h e r s o f N a t i o n a l I n s t i t u t e o f R a d i o l o g i c a l S c i e n c e s a n d W a s e d a U n i v e r s i t y .
T h u s , o u r d e p a r tm e n t t r e a t s v a r i e t y o f f i e l d s t o d e v e l o p t h e r a d i a t i o n o n c o l o g y w i t h g o o d b a l a n c e a m o n g c l i n i c a l r a d i a t i o n o n c o l o g y , r a d i a t i o n b i o l o g y , a n d m e d i c a l p h y s i c s .
RADIATION ONCOLOGY
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RADIATION ONCOLOGY
Research1 . C l i n i c a l o n c o l o g y U s e f u l n e s s o f h y p o f r a c t i o n a t e d w h o l e b r e a s t i r r a d i a t i o n f o r e a r l y b r e a s t c a n c e r R e s e a r c h f o r c a r b o n - i o n r a d i o t h e r a p y f o r e a r l y b r e a s t c a n c e r D e v e l o p m e n t o f m u l t i d i s c i p l i n a r y t r e a t m e n t f o r r e f r a c t o r y t u m o r s C l i n i c a l u t i l i t y o f h i g h - p re c i s i o n r a d i o t h e r a p y b y h i g h e n e r g y X - r a y O p t i m i z a t i o n o f i n t e n s i t y m o d u l a t e d r a d i a t i o n t h e r a p y f o r p r o s t a t e c a n c e r O p t i m i z a t i o n o f i n t e n s i t y m o d u l a t e d r a d i a t i o n t h e r a p y f o r b r a i n t u m o r O p t i m i z a t i o n o f s t e r e o t a c t i c i r r a d i a t i o n f o r e a r l y l u n g c a n c e r R e s e a r c h o n o p t i m i z a t i o n o f b r a c h y th e r a p y f o r p r o s t a t e c a n c e r O p t i m a l p o s t o p e r a t i v e i r r a d i a t i o n m e t h o d f o r b r e a s t c a n c e r
2 . M e d i c a l p h y s i c s R e s e a r c h f o r d e v e l o p m e n t o f u l t r a - c o m p a c t p r o t o n t h e r a p y s y s t e m R e s e a r c h f o r e f f e c t i v e i r r a d i a t i o n m e t h o d o f c a r b o n - i o n O p t i m i z a t i o n o f h i g h - p re c i s i o n r a d i a t i o n t h e r a p y O p t i m a l t r e a t m e n t p l a n n i n g f o r i n t e n s i t y - m o d u l a t e d r a d i a t i o n t h e r a p y S t u dy o n t h e r e d u c t i o n o f n o r m a l t i s s u e r e a c t i o n f r o m m e d i c a l p h y s i c s a p p r o a c h e s P r e d i c t i o n o f r a d i a t i o n s k i n r e a c t i o n 3 . R a d i a t i o n b i o l o g y C h e m i c a l m o d i f i c a t i o n o f c a r b o n - i o n r a d i o - s e n s i t i v i t y f o r b r e a s t c a n c e r S e a r c h o f r a d i o - s e n s i t i v i t y m o d i f i e r o n X - r a y a n d c h a r g e d p a r t i c l e r a d i o t h e r a p y D e v e l o p m e n t m e c h a n i s m o f l a t e r a d i a t i o n r e a c t i o n
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RADIATION ONCOLOGY
Faculty・P r o f e s s o r a n d C h a i r : K u m i k o K a r a s a w a , M D , P h D・V i s i t i n g p r o f e s s o r : T e i j i N i s h i o , P h D・L e c t u r e r : Y a i c h i r o H a s h i m o t o , M D , P h D・A s s o c i a t e l e c t u r e r : S a c h i k o I z u m i , M D・A s s i s ta n t p r o f e s s o r : C h i e T o r a m a t s u , P h D・A s s i s ta n t p r o f e s s o r : H i r o a k i M a t s u ba r a , P h D・P a r t - t i m e L e c t u r e r : M a s a s h i K o t o , M D , P h D・P a r t - t i m e L e c t u r e r : M a y u m i F u j i t a , P h D
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About usU n d e r C o n s t r u c t i o n
DIAGNOSTIC IMAGING AND NUCLEAR MEDICINE
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
publication
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About usO u r d e p a r tme n t o f f e r s m e d i c a l t r e a tmen t i n c l u d in g m a in l y s u r g i ca l i n t e r ve n t i o n s . Mu l t i d i s c i p l i n a ry t h e ra py , s u c h a s o p e r a t i o n w i t h c h e m othera p y a n d / o r r a d ia t i o n i s p e r f o rm f o r t r e a t i n g l u n g a n d a t h ym ic c a n c e rs . Nu m b e r o f o p e r a t i o ns i s f r om 2 5 0 t o 3 0 0 c a s e s a ye a r ( L u n g c a n c e r , 1 0 0 -11 0 c a s e s ; Me t a s ta t i c l u n g t u mors , 5 0 - 6 0 c a s e s ; Me d ia s t i n a l t u mo rs , 3 0 c a s e s ; Cys t i c l u n g d i s e a s e s , 5 0 c a s e s ) . A lm o s t a l l c a s e s h a ve b e e n p e r f o rme d b y t h o ra co sc op i c s u r g e ry . Co m p le te v i d e o - a s s i s te d t h o ra co sco p i c s e g mente c tomy o r s u b s e g mente c tomy wi t h r e f e r r i n g t o p a t i e n t s ’ i n d i v i d u a l v i r t u a l 3 - D p u lm o n ary m o d e l s i s p e r f o rmed f o r b o t h e a r l y s t a g e l u n g c a n c e r a n d m e t as ta t i c l u n g t u mo rs . Fo r p r im ary l u n g c a n c e r c a s e s s u c h a s m e d ia s t i n a l t u m ors a n d m ya s th en ia g r a v i s , r o b o t i c -a ss i s te d r e s e c t i o ns h a ve s t a r te d i n 2 0 1 2 . Va r i o u s p r o c e dure s , s u c h a s b r o n ch o sco p i c l a s e r t h e r ap y , a i r wa y s t e n t , a n d c a t he te r i n t e r ve n t i o n a r e p e r f o rme d f o r m a n y t h o r ac i c d i s e a s e s .
SURGERY Ⅰ( C H E S T S U R G E R Y )
Research1 . Ad va n c e im p r ove men t o f b o t h s im u la t i o n a n d n a v ig a t i o n f o r t h e p u lm o n ary r e s e c t i o n2 . S t u d y o f t h o r ac os cop i c s u r g i c a l t r e a tmen t a n d t h e c i r c u l a t i on o f t h e b l o o d i n t h e l u n g s
f o r t h e c h r o n i c p u lm o n ary e m p h ys ema3 . B r o n c h ia l a r t e r y i n f u s i o n f o r t r e a t i ng t h e l u n g c a n c e r4 . T i s s u e-e ng in eere d e p i t h e l i a l c e l l s h e e t s f o r c r e a t i n g a b i o a r t i f i c i a l t r ac he a5 . Re s ip a to ry o r g a ns r e g e nera t i o n6 . Ch e s t s u r g e ry w i t h b i o m a te r i a l s
FacultyMa s a t o KANZAKI , P r o f e ss o rMa s a h id e MURASUG I , As s o c ia te P r o f es so rKu n ih i r o O YAMA, As s i s t an t P r o f e ss o rT a m ami I SAKA, As s i s t an t P r o f es so r
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About usT h e g o a l o f t h i s p r o g ram i s t o p r o v i d e p r a c t i ca l e xp e r i e n ce s t o b e a n i n d e p e n d e n t r e s e a rch er o f c l i n i c a l r e s e arch . Yo u w i l l l e a r n a b o u t s c i e n t i f i c m e t ho ds i n d e s ig n , m e a s ure ment a n d e va lu a t i o n i n d e t a i l t h r o ug h a p a r t i c u l a r t h e me o f yo u r c l i n i c a l e xp e r t i s e .
SURGERY Ⅱ(BREAST, ENDOCRINE, PEDIATRIC SURGERY)
Research( 1 ) Pa t i e n t - re po r te d o u t c omes r e s e arc h i n e n d o c r i n e s u r g e ry( 2 ) C i r cu la t i n g t u m or c e l l s i n b r e a s t c a n c e r( 3 ) D rug m e t a bo l i sm a n d c a n c e r - re l a te d g e n e a n a l ys i s i n b r e a s t c a n c e r( 4 ) C l i n i c a l m a n a g eme nt o f l a p a r o sc op i c o p e r a t i o n i n p e d ia t r i c s u r g e ry( 5 ) Nu t r i t i o na l s t a tu s a f t e r g a s t rec tomy( 6 ) Surg i ca l s t r e ss( 7 ) Ro bo t i c s u r g e ry f o r c o l o r e c ta l c a n c e r( 8 ) La p aros co p i c s u r g e ry f o r i n f l a mmato ry b o we l d i s e a s e( 9 ) Para th y ro i d c a n c e r( 1 0 )Qua l i t y o f l i f e i n p a t i e n t s w i t h b r e a s t c a n c e r( 1 1 )B io marke r a n a l ys i s f o r t h y r o i d f o l l i c u l a r t u m or
FacultyT a k ah i ro O k a moto M i c h io I t ab as h iT a k ako Ka m io K i yo m i Ho r i u c h iO s a mu Se g a wa Ak i k o Sa k a motoAk i yo s h i Se s h im o Yo k o O m i publication
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About usU n d e r C o n s t r u c t i o n
CARDIOVASCULAR SURGERY
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
publication
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About usU n d e r C o n s t r u c t i o n
DEPARTMENT OF THERAPEUTIC STRATEGY FOR SEVERE HEART FAILURE
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
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About usT h e I n s t i t u t e o f G a s t r o e n t e r o l o g y , T o k y o W o m e n ’ s M e d i c a l U n i v e r s i t y ( T W M U ) w a s f o u n d e d i n 1 9 6 5 b y P r o f . K o m e i N a k a y a m a . T h e i n s t i t u t e l e a d s J a p a n e s e g a s t r o e n t e r o l o g i c a l s u r g e r y a n d i n t e r n a l m e d i c i n e a n d h a s e s t a b l i s h e d a s p e c i a l c l i n i c a l p o s t g r a d ua t e t r a i n i n g s y s t e m f o r y o u n g d o c t o r s . I n t h e p o s t g r a d ua t e s c h o o l o f T W M U , w e h a v e f o c u s e d o n r e g e n e r a t i v e m e d i c i n e , l i v e r t r a n s p l a n t a t i o n , c e l l t h e r a p y , i m m u n o t h e r a p y a n d g e n e t h e r a p y f o r t a i l o r - m a d e t r e a t m e n t . W e a w a i t a c t i v e y o u n g s u r g e o n s t o e n t e r o u r p o s t g r a d ua t e s c h o o l f o r c r e a t i n g a n e w e r a i n t h e 2 1 s t c e n t u r y .
GASTROENTEROLOGICAL SURGERY
Research1 . I m m u n e c e l l t h e r a p y (P r o f . E g a w a a n d K o t e r a)2 . O p e n M R I ( P r o f . O h k i )3 . B i o m a r k e r o f b i l e d u c t c a n c e r ( P r o f . Y a m a m o t o a n d H i g u c h i )4 . M u c i n p r o d uc i n g b i l i o p a n c r e a t i c t u m o r ( P r o f . F u r u k a w a a n d H i g u c h i )5 . R o b o t i c s u r g e r y f o r g a s t r o i n t e s t i n a l d i s e a s e (P r o f . Y a m a m o t o , I t a b a s h i a n d O h k i))
6 . I m a g i n g s y s t e m a n d I n t e r v e n t i o n a l R a d i o l o g y (P r o f . Y a m a m o t o a n d A r i i z um i)
FacultyPr o f . a n d Ch a i r m an:Ma sak a zu Ya m a moto As s o c ia te P r o f .:Ak i yo sh i Se s h im oPr o f .:Hi r o to Eg a wa As s o c ia te P r o f .:Mic h io I t ab as h iP r o f .:Ha rus h i O s u g i As s i s ta n t P r o f .:Yu j i I n o u ePr o f .:Sh yu n- i c h i A r i i zu m i As s i s ta n t P r o f .:Tak esh i O h k i
As s i s tan t As s i s t an t P r o f .:Yo sh ih i t o Ko t e r aAs s i s tan t P r o f .:Sh in pe i O g a waAs s i s tan t P r o f .:Ryo ta O g awa publication
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About usU n d e r C o n s t r u c t i o n
CHEMOTHERAPY ON DIGESTIVE ORGANS
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
publication
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About usU n d e r C o n s t r u c t i o n
NEUROSURGERY
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
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About usD i s e a s e s o f t h e b o n e , j o i n t , m u s c l e , n e r v e , w h i c h c a u s e d y s f u n c t i o n o f l i m b s a n d t r u n k s a r e o b s e r v e d , e x a m i n e d , d i a g n o s e d , t r e a t e d , a n d s t u d i e d i n o u r o r t h o p e d i c d e p a r t m e n t .T h e s e d i s e a s e s h a v e b e c o m e m o r e p o p u l a r o n e i n t h e a g i n g s o c i e t y , a n d w i l l r e s u l t i n t h e l o w q u a l i t y o f l i f e .M o s t o f J a p a n e s e p e o p l e c o m p l a i n e d o f l o w b a c k p a i n , n e c k s t i f f n e s s , u p p e r a n d l o w e r l i m b s p a i n , e s p e c i a l l y i n a g e d p e o p l e m o r e t h a n 6 5 y e a r s o l d .O u r d e p a r t m e n t f o c u s e d o n s p i n e d i s e a s e , o s t e o p o r o s i s , d y s f u n c t i o n o f b o n e m e t a b o l i s m , d e g e n e r a t e d j o i n t d i s e a s e , r h e u m a t o i d a r t h r i t i s , f r a c t u re i n c l i n i c a l t r e a t m e n t .
ORTHOPEDIC SURGERY
Research( 1 ) E l e c t o l o n i c s t i m u l a t i o n f o r t h e d i a g n o s i s o f f o r a m i n a l s t e n o s i s .( 2 ) C a r t i l a g e t i s s u e r e g e n e r a t i v e b i o l o g y u s i n g c e l l s h e e t .( 3 ) A p p l i c a t i o n o f a r t i f i c i a l l i g a m e n t s f o r a n i m a l m o d e l s o f A C L t e a r .( 4 ) A p p l i c a t i o n f o r t h e a u t o m a t i c m e a s u r e m e n t s o f b o n e m o r p h o l o g y i n d y s f u n c t i o n o f b o n e m e t a b o l i s m .
FacultyK e n O k a z a k i , M . D . , P h . D . M a s a s h i I t o , M . D .K e i j i W a d a , M . D . , P h . D . R y o T a m a k i , M . D .Y u j i M o r i t a , M . D . , P h . D . M i t s u ru Y u i , M . D .T a d a h i k o O h t s u ru , M . D . , P h . D . K a z u h i r o M a e d a , M . D .Y o k o H a g i w a r a , M . D . N o b u y uk i Y o s h i m o t o , M . D .K e n j i Y a s u i , M . D .N a o k o I w a k u r a , M . D .
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About usU n d e r C o n s t r u c t i o n
PLASTIC AND RECONSTRUCTIVE SURGERY
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
publication
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About usT h e i n f o r m a t i o n b y v i s u a l , i s s a i d t o a c c o u n t f o r m o r e t h a n 8 0 p e r c e n t o f t h e i n f o r m a t i o n r e c e i v e d f r o m t h e o u t s i d e w o r l d . F e e l i n g s a n d t h o u g h t s , i n c l u d i n g t h e e m o t i o n f r o m r e c e i v i n g i n f o r m a t i o n o c c u r , b a s e d o n i t , s u c h a s a c t s o f b e h a v i o r a n d r i s k a v e r s i o n i s e x p r e s s e d . I f d a t a v i s i o n i s l o s t , i t d e c r e a s e d o r l a c k o f c o l l e c t i o n o f i n f o r m a t i o n , f e e l i n g s a n d t h o u g h t s , t h e q u a l i t y a n d q u a n t i t y o f b e h a v i o r a n d a c t t o d e c r e a s e . T h i s l e a d s t o a d e c r e a s e o f t h e Q u a l i t y o f L i f e . O p h t h a l m o l o g y i s a s p e c i a l i z e d a r e a t o t h e v i s u a l d e g r a d a t i o n p r e v e n t i o n a n d r e c o v e r y .I n t h e S c h o o l o f M e d i c i n e e d u c a t i o n , w a s o b t a i n e d p a t h o l o g y , t h e t r e a t m e n t , t h e k n o w l e d g e i n a w i d e r a n g e f o r s u c h p r o g n o s i s . T h e s e k n o w l e dg e b a s e i s i n g r a d u a t e s c h o o l , a n d m o r e d e e p l y i n v e s t i g a t e t h e p a t h o g e n e s i s o f d i s e a s e s c a u s i n g v i s u a l i m p a i r m e n t , i s p r e v e n t i v e m e d i c i n e f o r s u p pr e s s i n g t h e o n s e t a n d p r o g r e s s i o n o f d i s e a s e b e c o m e s a t h e m e . T h e r e i s a v i t r e o r e t i n a l d i s e a s e s , i n c l u d i n g a g e - r e l a t e d m a c u l a r d e g e n e r a t i o n a s a r e s e a r c h f i e l d a t t h e i n t e r n a t i o n a l l e v e l i n o u r o p h t h a l m o l o g y . I n a d d i t i o n t o t h e r e t i n a , c o r n e a , u v e i t i s , s u c h a s p e r s p e c t i v e a m b l y o p i a , d o i n g r e s e a r c h t h e P a t h o g e n e s i s a n d p r e v e n t i o n o f v a r i o us f i e l d s .W e a r e s p e c i a l i s t s i n e a c h f i e l d , w e h a v e t o p r a c t i c e t h e b e s t o f t r e a t m e n t i n a c c o r da n c e w i t h t h e i n d i v i d ua l p a t i e n t s . I n a d d i t i o n , a s o p h t h a l m i c t o p r u n n e r , a n d h o r s e t a i l t o p r o v i d e a n d p r o m o t e a h i g h l y - a d v a n c e d m e d i c a l p r o g r e s s . . I n o p h t h a l m o l o g y , w e a r e t a k i n g a s y s t e m t h a t c a n t r e a t t h e d i s e a s e o f a l l t h e r e g i o n s . S y s t e m i c d i s e a s e i n t h e ( d i a b e t e s , h i g h b l o o d p r e s s ur e , c r a n i a l n e r v e d i s e a s e s , s u c h a s g a s t r o i n t e s t i n a l d i s e a s e ) e y e d i s e a s e s a s s o c i a t e d w i t h , h a v e d o n e t h e t r e a t m e n t i n c o o p e r a t i o n w i t h o t h e r d e p a r tm e n t s . B o t h a t h o m e a n d a b r o a d , w e o f f e r a h i g h e y e c a r e q u a l i t y a n d s a f e t y o f t h e h i g h e s t l e v e l .
OPHTHALMOLOGY
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OPHTHALMOLOGY
Research1 . C e l l b i o l o g i c a l r e s e a r c h a n d p a t h o l o g y a n a l y s i s o f r e t i n a a n d v i t r e o u s d i s e a s e s① s t u d y o f b l i n d n e s s p r e v e n t i o n b y v i t r e o r e t i n a l d i s e a s e② a g e - r e l a t e d m a c u l a r d e g e n e r a t i o n③ v i t r e o r e t i n a l i n t e r f a c e s y n d r o m e④ r e t i n o p a t h y o f p r e m a t u r i t y⑤ o t h e r s t u dy d i s e a s e s
2 . A s t u dy o f t h e a n t i - T N F - α a n t i b o d y t h e r a p y r e l a t e d t o p a t h o l o g y o f B e h c e t ' s d i s e a s e3 . I m m u n o l o g i c a l , m o l e c u l a r b i o l o g i c a l r e s e a r c h r e l a t e d t o t h e a c c u m u l a t i o n o f i n f l a m m a t o r y c e l l s o f a l l e r g i c c o n j u n c t i v i t i s4 . I m a g e a n a l y s i s o f t h e s t a b i l i t y o f t h e t e a r f i l m i n d r y e y e
FacultyC h i e f P r o f e s s o r c h i e f : T o m o h i r o I i d aC l i n i c a l P r o f e s s o r : E t s u k o T a k a m u r aA s s i s t a n t P r o f e s s o r : K a z u m i S h i n o z a k i
publication
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About usP o s t g r a d u a t e p r o g r a m s a t t h e d e p a r t m e n t o f o t o l a r y n g o l o g y a r e r e s e a r c h - b a s e d a s w e l l a s c l i n i c a l -b a s e d . T h e m a i n r e s e a r c h p r o j e c t s a r e a s f o l l o w s :
OTOLARYNGOLOGY
Research( 1 ) C l i n i c a l h i s t o p a t h o l o g i c a l s t u d y o f I g G 4 - r e l a t e d s a l i v a r y g l a n d d i s e a s e s a n d s i n u s i t i s .( 2 ) E f f i c a c y o f a n t i‐ i m m u n o g l o b u l i n E a n t i b o d y ( o m a l i z u m a b ) i n k i m u r a ' s d i s e a s e .( 3 ) T h e n o v e l t r e a t m e n t s t r a t e g i e s f o r e o s i n o p h i l i c s i n u s i t i s a n d e o s i n o ph i l i c o t i t i s m e d i a .( 4 ) E v a l u a t i o n o f s a l i v a r y g l a n d f u n c t i o n w i t h n e a r i n f r a r e d s p e c t r o c h e m i c a l a n a l y s i s s y s t e m ( W O T - S 2 0 )( 5 ) C l i n i c a l S t u d y o f M 3 s e l e c t i v e m u s c a r i n i c a n t a g o n i s t s i n t h e t r e a t m e n t o f s i a l o r r h e a
FacultyM a n a b u N o n a k a C l i n i c a l P r o f e s s o rY u k i e Y a m a m u r a S e n i o r A s s i s t a n t P r o f e s s o rN o r i o K o n d o u A s s i s ta n t P r o f e s s o rK a o r u K u s a m a A s s i s ta n t P r o f e s s o rY u k a k o S e o A s s i s t a n t P r o f e s s o rE r i S a k i t a n i A s s i s t a n t P r o f e s s o rM a y a k o T a c h i k a w a A s s i s t a n t P r o f e s s o rK e i k o K u j i r a i A s s i s t a n t P r o f e s s o r publication
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About usU n d e r C o n s t r u c t i o n
OBSTETRICS AND GYNECOLOGY
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
publication
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About usU n d e r C o n s t r u c t i o n
ANESTHESIOLOGY
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
publication
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About usW e f o c u s o n s e v e r a l a s p e c t s o f t h e u r o l o g i c a l f i e l d i n c l u d i n g k i d n e y t r a n s p l a n t a t i o n , u r o l o g i c a l c a n c e r , f e m a l e u r o l o g y , p e d i a t r i c u r o l o g y , a n d u r i n a r y s t o n e . I n e a c h f i e l d , w e h a v e s e v e r a l s p e c i a l i s t s . R e g a r d i n g k i d n e y t r a n s p l a n t a t i o n , t h e n u m b e r o f s u r g e r i e s i s m o r e t h a n 1 0 0 , a n d t h e 1 0 - y e a r g r a f t s u r v i v a l r a t e i s m o r e t h a n 9 0 % , w h i c h i s a n e x c e l l e n t o u t c o m e . I n a d d i t i o n , w e h a v e n e a r l y 3 0 0 s u r g i c a l c a s e s o f k i d n e y c a n c e r , t h e h i g h e s t i n J a p a n . R o b o t i c s u r g e r y h a s b e e n a d o p t e d i n p a r t i a l n e p h r e c t o m y a n d r a d i c a l p r o s t a t e c to m y a n d t h e n u m b e r o f c a s e s i s r a p i d l y i n c r e a s i n g . O u r b a s i c r e s e a r c h h a s a l l o w e d f o r p r o v i d i n g i m m u n o t h e r a p y u s i n g γ δ c e l l s t o p a t i e n t s w i t h m e t a s t a s i s f r o m u r o l o g i c a l c a n c e r s u c h a s k i d n e y c a n c e r , b l a d de r c a n c e r , o r p r o s t a t e c a n c e r c a n r e c e i v e . A s m e n t i o n e d a b o v e , w e p r o v i d e t h e l a t e s t m e d i c a l s e r v i c e c o r r e s p o n d i n g t o t h e d i v e r s i f y i n g d e m a n d s f r o m p a t i e n t s .
UROLOGY
Research( 1 ) I m m u n e t o l e r a n c e( 2 ) K i d n e y t r a n s p l a n t a t i o n( 3 ) C a r c i n o g e n e s i s a n d c y s t f o r m a t i o n o f k i d n e y( 4 ) C h e m o a b l a t i o n f o r p r o s t a t e c a n c e r( 5 ) K i d n e y d y s f u n c t i o n a f t e r u r i n a r y t r a c t o b s t r uc t i o n( 6 ) C a u s e o f p r o g r e s s i o n a n d m e t a s t a s i s o f p r o s t a t e c a n c e r( 7 ) P r e v e n t i o n o f u r i n a r y s t o n e( 8 ) O u t c o m e o f n e p h r o n - s pa r i n g s u r g e r y f o r k i d n e y c a n c e r( 9 ) P r e v e n t i o n o f r e c u r r e n c e o f b l a d d e r c a n c e r( 1 0 ) D i a g n o s i s a n d t r e a t m e n t o f r e n o v a s c u l a r h y p e r te n s i o n( 1 0 ) γ δ t h e r a p y f o r u r o l o g i c c a n c e r
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UROLOGY
FacultyK a z u n a r i T a n a b eH i d e k i I s h i d aT s u n e n o r i K o n d oH i r o h i t o K o b a y a s h iT o m o k a z u S h i m i z uM a s a y o s h i O k u m iT o s h i o T a k a g iK a z u y a O m o t oJ y u n p e i I i z u k aT o s h i h i t o H i r a iA k i k o S a k o t a
publication
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About usD e p a r t m e n t o f O r a l a n d M a x i l l o f a c i a l S u r g e r y i s r e s p o n s i b l e f o r t h e d i a g n o s i s , t r e a t m e n t , o r p r e v e n t i o n f o r d i s e a s e s i n t h e o r a l a n d m a x i l l o f a c i a l r e g i o n . B e c a u s e r e s e a r c h i n t h i s f i e l d i s i m p o r t a n t n o t o n l y f o r e a t i n g , c h e w i n g , o r s w a l l o w i n g , b u t a l s o f o r a e s t h e t i c , i t c a n b e e x p e c t e d t o e x p a n d f u r t h e r i n t e r e s t i n g s t u d i e s . J a w b o n e r e g e n e r a t i o n h a s b e e n a t t e m p t e d f o r a l o n g t i m e b y o r a l s u r g e o n s , a n d t h e r e a r e s t e m c e l l s o u r c e s i n t h e o r a l c a v i t y . T h e r e f o r e , r e g e n e r a t i v e m e d i c i n e i s f a m i l i a r t o t h e o r a l a n d m a x i l l o f a c i a l s u r g e r y a s a r e s e a r c h f i e l d . F o r t h o s e r e a s o n s , w e a r e e s p e c i a l l y f o c u s i n g t h e r e s e a r c h a b o u t r e g e n e r a t i v e m e d i c i n e . Y o u c a n s t u d y i n c o l l a b o r a t i o n w i t h o t h e r d e p a r t m e n t s , u n i v e r s i t i e s , o r i n s t i t u te s f o r a v a r i e t y o f r e s e a r c h .
ORAL AND MAXILLOFACIAL SURGERY
Research( 1 ) R e g e n e r a t i v e t h e r a p y i n t h e o r a l a n d m a x i l l o f a c i a l r e g i o n u s i n g “ c e l l s h e e t e n g i n e e r i n g ”W e a r e r e s e a r c h i n g a b o u t “ c e l l s h e e t e n g i n e e r i n g ” i n c o l l a b o r a t i o n w i t h I n s t i t u t e o f A d v a n c e d B i o m e d i c a l E n g i n e e r i n g a n d S c i e n c e , T o k y o W o m e n ’ s M e d i c a l U n i v e r s i t y ( T W I n s ) . W e h a v e c o m p l e t e d a c l i n i c a l s t u d y o f A u t o l o g o u s p e r i o d o n t a l l i g a m e n t c e l l s h e e t t r a n s p l a n t a t i o n f o r p e r i o do n t i t i s , a n d c o n f i r m e d t h e l o n g - t e r m s t a b i l i t y a n d t h e i r s a f e t y o f t h i s c y t o t h e r a p y . M o r e o v e r , w e d e m o n s t r a t e d t h a t b o n e m a r r o w d e r i v e d m e s e n c h y m a l s t r o m a l c e l l s h e e t t r a n s p l a n t a t i o n i s e f f e c t i v e f o r b i s p h o s p h o n a t e -r e l a t e d o s t e o n e c r o s i s o f t h e j a w i n a r a t m o d e l . B e s i d e s , w e a r e r e s e a r c h i n g a b o u t o r a l m u c o s a l r e g e n e r a t i o n o r d e n t a l i m p l a n t s u s i n g t i s s u e e n g i n e e r i n g . O u r g o a l i s a c t u a l l y t o d e l i v e r a n e w t r e a t m e n t t o p a t i e n t s . ( 2 ) A s s e s s m e n t o f h u m a n i n t r a o r a l m e c h a n i c a l a n d t h e r m a l s e n s i t i v i t y w i t h n o v e l s i m p l e d e v i c e s i n t h e c l i n i c : i m p l i c a t i o n s f o r o r o f a c i a l p a i n c o n d i t i o n s .T h e r e l i a b i l i t y o f i n t r a o r a l m e c h a n i c a l a n d t h e r m a l s e n s i t i v i t y r e c o r de d w i t h t h e i n t r a o r a l s i m p l e d e v i c e s w a s a p p l i c a b l e . T h i s s e m i q u a n t i t a t i v e a s s e s s m e n t o f i n t r a o r a l m e c h a n i c a l a n d t h e r m a l s e n s i t i v i t y i s f e a s i b l e f o r c l i n i c a l s t u d i e s i n d i f f e r e n t i n t r a o r a l p a i n c o n d i t i o n s . T h e a i m o f o u r p r o j e c t s i s t o i n v e s t i g a t e i n t r a o r a l s o m a t o s e n s o r y c h a n g e s i n p a t i e n t s w i t h o r o f a c i a l p a i n c o n d i t i o n s a n d t o e v a l u a t e t h e e f f e c t s o f t h e t r e a t m e n t s .
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ORAL AND MAXILLOFACIAL SURGERY
( 3 ) P e r i p h e r a l n e r v e r e g e n e r a t i o n u s i n g d e n t a l p u l p c e l l sW e s t u dy p e r i p h e r a l n e r v e r e g e n e r a t i o n w i t h d e n t a l p u l p c e l l s , b e c a u s e d e n t a l p u l p t i s s u e c o n t a i n s S c h w a n n c e l l s a n d n e u r a l p r o g e n i t o r c e l l s . A n e r v e g u i d e c o n t a i n i n g d e n t a l p u l p c e l l s i n t y p e I c o l l a g e n g e l i s t r a n s p l a n t e d i n t o a g a p o f t h e f a c i a l n e r v e i n r a t s a n d m i n i a t u r e p i g s . T h e r e c o v e r y i s i n v e s t i g a t e d b y h i s t o l o g i c a l , f u n c t i o n a l , a n d e l e c t r o p h y s i o l o g i c a l a n a l y s i s s e v e r a l m o n t h s a f t e r t r a n s p l a n t a t i o n .
( 4 ) U s e o f d e r m o s c o p y f o r t h e d i a g n o s i s o f o r a l m u c o s a l d i s e a s e sD e r m o s c o pe s a r e l o u p e s f o r e x a m i n i n g p i g m e n t e d s k i n l e s i o n s n o n i n v a s i v e l y , a n d t h e y a r e u s e f u l i n d e r m a t o l o g y f o r m a k i n g a n e a r l y d i f f e r e n t i a l d i a g n o s i s b e t w e e n m e l a n o m a a n d m e l a n o c y t i c n e v i . W e a r e r e s e a r c h i n g a b o u t t h e d i a g n o s i s u s i n g d e r m a s c o p y f o r o r a l m u c o s a l d i s e a s e s , i n c l u d i n g o r a l l i c h e n p l a n u s , p e m p h i g u s , l e u k o p l a k i a , o r i n i t i a l c a n c e r .
FacultyP r o f e s s o r T o m o h i r o A n d o D . D . S . , P h . D . A s s o c i a t e P r o f e s s o r T o s h i h i r o O k a m o t o D . D . S . , P h . D . A s s o c i a t e P r o f e s s o r T a k a n o r i I w a t a D . D . S . , P h . D . A s s i s t a n t P r o f e s s o r K e n j i F u k a d a D . D . S . , P h . D .A s s i s t a n t P r o f e s s o r R y o S a s a k i D . D . S . , P h . D .A s s i s t a n t P r o f e s s o r T o s h i y u k i K a t a o k a D . D . S .A s s i s t a n t P r o f e s s o r A k i r a S h i m a s a k i D . D . S .A s s i s t a n t P r o f e s s o r T a k u y a N a g a n a w a D . D . S . , P h . D .A s s i s t a n t P r o f e s s o r S a t o s h i F u k u z a w a D . D . S . publication
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About usU n d e r C o n s t r u c t i o n
CRITICAL CARE ANDEMERGENCY MEDICINE
ResearchU n d e r C o n s t r u c t i o n
FacultyU n d e r C o n s t r u c t i o n
publication
![Page 70: GRADUATE SCHOOL OF MEDICAL SCIENCEmedical research, we aim at determine molecular pathomechanisms of human diseases using materials obtained from human tissues as well as experimental](https://reader034.vdocuments.site/reader034/viewer/2022042809/5f94fad03c97923de722efc7/html5/thumbnails/70.jpg)
About usT h e F a c u l t y o f A d v a n c e d T e c h n o - S u r g e r y ( F A T S ) c o n d u c t s r e s e a r c h a n d d e v e l o pm e n t t o b r i n g a b o u t h i g h e r l e v e l s o f q u a l i t y i n m e d i c a l c a r e . A t t h e c o r e o f o u r r e s e a r c h i s i m a g e - g u i d e d s u r g e r y ( I G S ) p e r f o r m e d i n o u r i n t e l l i g e n t o p e r a t i n g t h e a t e r . S i n c e a d o p t i n g i n t r a o p e r a t i v e m a g n e t i c r e s o n a n c e i m a g i n g ( M R I ) i n M a r c h 2 0 0 0 , a s o f J u l y 2 0 1 6 , w e h a v e p e r f o r m e d I G S o n 1 6 2 3 p a t i e n t s , a n d i n d o i n g s o , h a v e c o n t r i b u t e d t o t h e s p r e a d o f t h i s m o d a l i t y f r o m i t s i n c e p t i o n . N o w t h a t w e a r e e n t e r i n g t h e a g e o f i n f o r m a t i o n - g u i d e d s u r g e r y , F A T S a i m s t o i m p r o v e t h e q u a l i t y o f m u l t i d i s c i p l i n a r y m e d i c a l c a r e , n o t o n l y v i a e x i s t i n g m o d a l i t i e s o f i n t r a o p e r a t i v e M R I a n d u p d a t e d n e u r o - n a v i g a t i o n s y s t e m s , b u t a l s o t h r o u g h t h e a d d i t i o n o f a r a n g e o f i n n o v a t i v e m o d a l i t i e s t h a t c a n d e l i v e r s e a m l e s s s u p p o r t i n p r e - , i n t r a - , a n d p o s t - s u rg e r y s e t t i n g s . E x a m p l e s o f t h e s e t e c h n i q u e s a n d p r o c e d u r es i n c l u d e M R s p e c t ro s c o p y , a w a k e c r a n i o t o m y , i n t r a o p e r a t i v e e x a m i n a t i o n m o n i t o r i n g f o r a w a k e s u r g e r y ( I E M A S ) , r a p i d i n t r a o p e r a t i v e p a t h o l o g i c a l d i a g n o s i s , i n t r a o p e r a t i v e d i a g n o s i s o f m a l i g n a n c y u s i n g f l o w c y t o m e t ry , p h o t o d y n a m i c d i a g n o s i s a n d t r e a t m e n t , t o u c h l e s s i n t e r f a c e ( O p e c t ) , a u t o m a t e d t r a c k i n g r o b o t i c a r m ( i A r m S ) , a n d h i g h e r b r a i n f u n c t i o n t e s t i n g . W e a r e a l s o w o r k i n g t o r e a l i z e t h e i n t e g r a t i o n o f t h e s e t e c h n o l o g i e s i n o u r S m a r t C y b e r O p e r a t i n g T h e a t e r ( S C O T ) b y e x p a n d i n g o u r r e s e a r c h a n d d e v e l o p m e n t ( R & D ) f r a m e w o r k t o e n c o m p a s s i n t e r d i s c i p l i n a r y p a r t n e r s h i p s i n t h e f i e l d o f m e d i c a l e n g i n e e r i n g w i t h a c a d e m i a , i n d u s t r y , a n d g o v e r n m e n t .I n t h e f i e l d o f o n c o l o g y , w e a r e s t r i v i n g t o r e a l i z e t h e f o u r t h m o d a l i t y o f c a n c e r t h e r a p y a f t e r s u r g e r y , r a d i o t h e r a p y , a n d c h e m o t h e r a p y , n a m e l y s o n o d y n a m i c t h e r a p y , c o m b i n i n g t h e u s e o f h i g h i n t e n s i t y f o c u s e d u l t r a s o u n d t h e r a p y a n d s o n o s e n s i t i z e r . H o w e v e r , o u r e m p h a s i s i s n o t s o l e l y o n t e c h n o l o g i c a l d e v e l o p m e n t , a n d w e a r e a l s o f o c u s e d o n i n i t i a t i v e s t o o b t a i n i n t e r n a t i o n a l s t a n d a r d .O u r f a c u l t y b r i n g a m u l t i d i s c i p l i n a r y a p p r o a c h t o a l l o f o u r p r o c e s s e s , f r o m b a s i c r e s e a r c h t o c l i n i c a l a p p l i c a t i o n a n d p r o d u c t d e v e l o p m e n t . T h e i r e f f o r t s a r e f o r g i n g a m o d e l f o r o u r n e x t - g e n e r a t i o n c o l l a b o r a t i v e ( i n t e r d i s c i p l i n a r y ) m e d i c a l e n g i n e e r i n g r e s e a r c h , t r a n s l a t i o n a l r e s e a r c h , a n d c o m m e r c i a l i z a t i o n o f p r o d uc t .
ADVANCED TECHNO-SURGERY
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ADVANCED TECHNO-SURGERY
Research( 1 ) S u r g i c a l s t r a t e g y s y s t e m s i n t h e f i e l d o f n e u r o s u r g e r yS u r g e r y — a n d n e u r o s ur g e r y i n p a r t i c u l a r — i s h o s t t o h i g h l y c o m p l e x s y s t e m s c h a r a c te r i z e d b y t h e c o n t i n u o u s i n t r o d uc t i o n o f v a r i o u s e q u i p m e n t f o r t e s t i n g , d i a g n o s i s , a n d t r e a t m e n t . T h e k e y t o s u c c e s s f u l s u r g e r y l i e s i n l e v e r a g i n g t h e i n f o r m a t i o n f r o m t h e s e s y s t e m s t o o p t i m i z e p r o c e d u re s b y d e v e l o p i n g t h e b e s t s u r g i c a l p l a n s a n d m o d i f y i n g t h e s e p l a n s i n r e s p o n s e t o t h e s u r g i c a l p r o c e s s . I n t h i s r e s e a r c h t h e m e , s t u de n t s w i l l l e a r n h o w t o p l a n f o r s u r g e r y p r e o p e r a t i v e l y , h o w t o m o n i t o r p r o g r e s s b y v i s u a l i z i n g i n t r a o p e r a t i v e i n f o r m a t i o n , h o w t o s y s t e m a t i c a l l y a n d e f f e c t i v e l y m o d i f y t h e s u r g e r y t o r e s o l v e a n y i d e n t i f i e d i s s u e s , a n d h o w t o d e v e l o p t h e s o f t w a r e a n d h a r d w a r e t o a c h i e v e t h e s e g o a l s .S t u de n t s w i l l b e r e q u i r e d t o r e p o r t o n t h e p r o g r e s s o f t h e i r r e s e a r c h i n a n a c a d e m i c p r e s e n t a t i o n s e t t i n g t w i c e a y e a r s o t h a t t h e t e a c h i n g s t a f f c a n p r o v i d e f e e d b a c k a n d g u i d a n c e o n t h e i r r e s e a r c h p r e s e n t a t i o n s k i l l s .
( 2 ) S u r g i c a l r i s k m a n a g e m e n t u s i n g s u r g e r y r e c o r de r a n d s i m u l a t o r s y s t e m sS u r g e r y r e c o r de r s y s t e m s f o r d i g i t a l l y r e c o r d i n g a n d s t o r i n g i n t r a o p e r a t i v e a n e s t h e s i a m a n a g e m e n t
d a t a , p a t i e n t p h y s i o l o g i c a l d a t a ( w e a r a b l e d e v i c e d a t a ) , a n d s u r g i c a l d a t a ( v i d e o d a t a o f t h e o p e r a t i v e f i e l d ) a r e e s s e n t i a l f o r s t r e a m l i n i n g a n d o p t i m i z i n g r i s k m a n a g e m e n t i n s u r g e r y . S u r g e r y s i m u l a t o r s y s t e m s h a v e t h e p o t e n t i a l t o b e a n i n v a l u a b l e d a t a -g a t h e r i n g t o o l f o r t h e a n a l y s i s a n d a s s e s s m e n t o f u n f o r e s e e n p r o b l e m s . I n t h i s r e s e a r c h t h e m e , s t u d e n t s w i l l l e a r n h o w t o d e v e l o p s u r g e r y r e c o r d e r a n d s i m u l a t o r s y s t e m s t o h e l p e n s u r e t h a t s u r g e r i e s a r e p e r f o r m e d s a f e l y .S t u de n t s w i l l b e r e q u i r e d t o r e p o r t o n t h e p r o g r e s s o f t h e i r r e s e a r c h i n a n a c a d e m i c p r e s e n t a t i o n s e t t i n g t w i c e a y e a r s o t h a t t h e t e a c h i n g s t a f f c a n p r o v i d e f e e d b a c k a n d g u i d a n c e o n t h e i r r e s e a r c h p r e s e n t a t i o n s k i l l s .
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ADVANCED TECHNO-SURGERY
( 3 ) M i n i m a l l y i n v a s i v e n e u r o s u r g e r y s y s t e m s b a s e d o n a u g m e n t e d r e a l i t yI n t h e s u r g i c a l f i e l d , n a v i g a t i o n t e c h n i q u e s a r e s e e n a s a n i m p o r t a n t a i d f o r n a r r o w o p e r a t i v e f i e l d m a n e u v e r s t o m i n i m i z e i n v a s i v e n e s s . T h e c o r e t e c h n o l o g y o f a u g m e n t e d r e a l i t y ( A R ) p r o v i d e s c o m p r e h e n s i v e r e a l - t i m e i n f o r m a t i o n t o a s s i s t t h e s u r g e o n w i t h a c o n s t a n t l e v e l o f p r e c i s i o n , c o n s i s t e n c y , a n d o b j e c t i v i t y , w h i l e e l i m i n a t i n g t h e n e e d t o r e l y o n e x p e r i e n c e a n d i n t u i t i o n t o c o n f i r m t h e c u r r e n t p o s i t i o n o f t h e s u r g i c a l a r e a a n d p r o g r e s s o f t h e s u r g i c a l p r o c e d ur e . T h i s r e s e a r c h t h e m e a i m s t o e q u i p s t u d e n t s w i t h t h e s k i l l s t o b o t h d e v e l o p a n d u t i l i z e a m i n i m a l l y i n v a s i v e n e u r o s u r g e r y s y s t e m t h r o ug h t h e a d v a n c e d u s e o f A R .S t u de n t s w i l l b e r e q u i r e d t o r e p o r t o n t h e p r o g r e s s o f t h e i r r e s e a r c h i n a n a c a d e m i c p r e s e n t a t i o n s e t t i n g t w i c e a y e a r s o t h a t t h e t e a c h i n g s t a f f c a n p r o v i d e f e e d b a c k a n d g u i d a n c e o n t h e i r r e s e a r c h p r e s e n t a t i o n s k i l l s .
( 4 ) S u r g i c a l a s s i s ta n c e r o b o t i c d e v i c e sI n t h i s r e s e a r c h t h e m e , s t u d e n t s w i l l r e s e a r c h a n d d e v e l o p r o b o t i c s u r g i c a l l a s e r s a n d n e w s u r g i c a l d e v i c e s u s i n g u l t r a s o u n d a n d l a s e r s i n o r d e r t o p r o v i d e s u r g e o n s w i t h a “ n e w h a n d ” c a p a b l e o f r e a l i z i n g a l e v e l o f a c c u r a c y , r e s o l u t i o n , a n d o p e r a b i l i t y t h a t e x c e e d s t h a t o f h u m a n h a n d s b y u t i l i z i n g m e c h a n i c a l , e l e c t r o n i c , i n f o r m a t i o n a l , e n g i n e e r i n g , a n d c o m p u t e r - a s s i s te d s u r g i c a l t e c h n i q u e s . S t u de n t s w i l l t a k e a m e d i c a l e n g i n e e r i n g a p p r o a c h t o t h e i r r e s e a r c h o n t h e c o n c e p t ua l d e s i g n , r e a l i z a t i o n , f u n c t i o n s , a n d e f f e c t s o f v a r i o u s d i a g n o s t i c a n d t h e r a p e u t i c s u p p o r t i v e d e v i c e s i n a n u m b e r o f f i e l d s i n c l u d i n g n e u r o s u r g e r y , a b d o m i n a l s u r g e r y , a n d t h o r a c i c s u r g e r y .S t u de n t s w i l l b e r e q u i r e d t o r e p o r t o n t h e p r o g r e s s o f t h e i r r e s e a r c h i n a n a c a d e m i c p r e s e n t a t i o n s e t t i n g t w i c e a y e a r s o t h a t t h e t e a c h i n g s t a f f c a n p r o v i d e f e e d b a c k a n d g u i d a n c e o n t h e i r r e s e a r c h p r e s e n t a t i o n s k i l l s .
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ADVANCED TECHNO-SURGERY
( 5 ) R o b o t i c d e v i c e s f o r c e l l s h e e t t r a n s p l a n t a t i o nI n t h i s r e s e a r c h t h e m e , s t u d e n t s w i l l c o n d u c t R & D o n d e v i c e s c a p a b l e o f c l e a n - e n v i r o n m e n t , m i n i m a l l y i n v a s i v e , s i m p l e i n v i v o t r a n s p l a n t a t i o n o f r e g e n e r a t i v e c e l l t i s s u e s p r o d uc e d b y a u t o m a t e d c e l l s h e e t c u l t u r i n g a n d s t a c k i n g s y s t e m s u s i n g t e m p e r a t u re - r e s p o n s i v e p o l y m e r s . S p e c i f i c a l l y , s t u d e n t s w i l l r e s e a r c h a n d d e v e l o p d e v i c e s t o t r a n s p l a n t m y o c a r d i a l c e l l a n d f i b r o b l a s t s h e e t s .S t u de n t s w i l l b e r e q u i r e d t o r e p o r t o n t h e p r o g r e s s o f t h e i r r e s e a r c h i n a n a c a d e m i c p r e s e n t a t i o n s e t t i n g t w i c e a y e a r s o t h a t t h e t e a c h i n g s t a f f c a n p r o v i d e f e e d b a c k a n d g u i d a n c e o n t h e i r r e s e a r c h p r e s e n t a t i o n s k i l l s .
( 6 ) R e g u l a t o r y s c i e n c e f o r m e d i c a l d e v i c e sJ a p a n ’ s m e d i c a l d e v i c e m a n u f a c t u r i n g i n d u s t r y c u r r e n t l y f a c e s a d i s c o n n e c t i n t e r m s o f i t s a b i l i t y t o d e v e l o p d e v i c e s a n d i t s i n a b i l i t y t o c o m m e r c i a l i z e t h e m . I n p a r t i c u l a r , t h e i n d u s t r y i s f a c i n g a c r i s i s d u e t o i t s i n a b i l i t y t o c o m m e r c i a l i z e t h e r a p e u t i c d e v i c e s , t h e m a j o r i t y o f w h i c h a r e c l i n i c a l l y t e s t e d a n d c o m m e r c i a l i z e d o v e r s e a s . T h e u n d e r l y i n g c a u s e o f t h i s i n a b i l i t y t o m a n u f a c t u r e i s r i s k a v e r s i o n b y a l l s t a k e h o l d e r s i n c l u d i n g t h e p u b l i c , d e v e l o p e r s , m a n a g e m e n t , a n d r e g u l a t o r y a u t h o r i t i e s . A s s u c h , m e a s u r e s t o m i t i g a t e r i s k a r e e s s e n t i a l t o o v e r c o m i n g t h i s s i t u a t i o n . I t i s a l s o c r u c i a l t o f o c u s o n d a t a p a c k a g i n g f r o m t h e d e v e l o p m e n t s t a g e w i t h a n e y e t o r e g u l a t o r y a p p r o v a l a n d c o m m e r c i a l i z a t i o n a n d t o s u b m i t p r o p r i e t a r y s c i e n t i f i c e v i d e n c e f o r s a f e t y a n d e f f i c a c y e v a l u a t i o n . I n t h i s r e s e a r c h t h e m e , s t u d e n t s w i l l i n v e s t i g a t e t h e r e g u l a t o r y s c i e n c e r e q u i r e d t o d e v e l o p v a r i o u s m e d i c a l d e v i c e s .S t u de n t s w i l l b e r e q u i r e d t o r e p o r t o n t h e p r o g r e s s o f t h e i r r e s e a r c h i n a n a c a d e m i c p r e s e n t a t i o n s e t t i n g t w i c e a y e a r s o t h a t t h e t e a c h i n g s t a f f c a n p r o v i d e f e e d b a c k a n d g u i d a n c e o n t h e i r r e s e a r c h p r e s e n t a t i o n s k i l l s .
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ADVANCED TECHNO-SURGERY
( 7 ) S t e r e o t a c t i c a n d f u n c t i o n a l m i c r o - r a d i o s u r g e r yI n g a m m a k n i f e r a d i o s u rg e r y , t h e s u r g e o n u s e s g a m m a r a d i a t i o n a s t h o u g h u s i n g a k n i f e t o r e m o v e b r a i n t u m o r s w i t h o u t h a r m i n g t h e s u r r o u n d i n g n o r m a l b r a i n t i s s u e i n a n a t t e m p t t o r a d i c a l l y r e s e c t t h e t u m o r . T h e g a m m a k n i f e d e v i c e c o n t a i n s 1 9 2 c o b a l t - 6 0 ( C o 6 0 ) s o u r c e s a r r a n g e d i n a c o n c e n t r i c a n d s e m i - c i r c u l a r a r r a y . T h e d e v i c e i s d e s i g n e d t o f o c u s t h e g a m m a r a d i a t i o n o n a s i n g l e p o i n t t o d e l i v e r a s i n g l e h i g h d o s e o f r a d i a t i o n t o t h e t a r g e t l e s i o n . C u r r e n t g a m m a k n i f e t e c h n o l o g y i s c a p a b l e o f a u t o m a t i c a l l y t a r g e t i n g a n y l o c a t i o n w i t h i n t h e b r a i n , i n c l u d i n g t u m o r s l o c a t e d i n t h e c r a n i o c e r v i c a lj u n c t i o n , w i t h a n a c c u r a c y o f 0 . 1 m m . U s i n g t h i s p r e c i s e r a d i o s ur g i c a l d e v i c e , s t u d e n t s w i l l s t u d y t h e t h e r a p e u t i c a c c u r a c y a n d c l i n i c a l o u t c o m e s o f s t e r e o t a c t i c a n d f u n c t i o n a l m i c r o - r a d i o s u r g e r y .S t u de n t s w i l l b e r e q u i r e d t o r e p o r t o n t h e p r o g r e s s o f t h e i r r e s e a r c h i n a n a c a d e m i c p r e s e n t a t i o n s e t t i n g t w i c e a y e a r s o t h a t t h e t e a c h i n g s t a f f c a n p r o v i d e f e e d b a c k a n d g u i d a n c e o n t h e i r r e s e a r c h p r e s e n t a t i o n s k i l l s .
FacultyP r o f e s s o r :Y o s h i h i r o M u r a g a k i , K e n M a s a m u n eA s s o c i a t e P r o f e s s o r : K y o j i r o N a m b uA s s i s t a n t P r o f e s s o r : M a n a b u T a m u r a , M i k h a i l C h e r n o v , J u n O k a m o t o , M o t o h i r o H a y a s h i ( o n j o i n t a p p o i n t m e n t ) , T a k a s h i M a r u y a m a ( o n j o i n t a p p o i n t m e n t )I n s t r u c t o r :S o k o I k u t a , C h i h a r u N i k i , Y o s h i y uk i K o n i s h i , Y u k i H o r i s e , K a o r i K u s u da ,M a s a y uk i N i t t a ( o n j o i n t a p p o i n t m e n t ) publication
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About usI n A p r i l 2 0 0 3 , w h o l e h u m a n g e n o m e s e q u e n c i n g w a s d e c l a r e d b y p r e s i d e n t s o f 6 c o u n t r i e s ; t h e U n i t e d S t a t e s , U n i t e d K i n g d o m , J a p a n , F r a n c e , G e r m a n y , a n d C h i n a , a n d t h e w o r l d h a d e n t e r e d i n t o t h e p o s t g e n o m e e r a . G e n o m e r e s e a r c h e s w i t h n e w d i r e c t i o n s a r e n o w e x p a n d i n g w o r l d w i d e , s u c h a s g e n o m e -b a s e d d r u g d i s c o v e r y a n d p e r s o n a l i z e d t r e a t m e n t . T h e s o c i a l a t t e n t i o n h a s b e e n h e i g h t e n e d a n d f o c u s e d o n g e n o m e a s m o r e t h a n e v e r b e f o r e , a n d g e n o m e s a r e a n t i c i p a t e d t o t a k e a v e r y i m p o r t a n t r o l e i n c o r e m e d i c i n e a n d i n a p a r t o f i n d u s t r y i n t h e n e a r f u t u r e . M o l e c u l a r b i o l o g y a n d c e l l b i o l o g y , w h i c h h a d b e e n i m p o r t a n t s o f a r , w o u l d t a k e l a r g e r o l e a s e v e r . H o w e v e r , m o r e s i g n i f i c a n t r o l e w o u l d b e h e l d b y g e n e t i c s t a t i s t i c s , g e n o m i c e t h i c s , g e n e t i c d i a g n o s t i c s a n d g e n e t h e r a p i e s . I n t h e A f f i l i a t e d F i e l d o f M e d i c a l G e n e t i c s , D i v i s i o n o f B i o m e d i c a l E n g i n e e r i n g a n d S c i e n c e , G r a d u a t e S c h o o l o f M e d i c i n e , T o k y o W o m e n ' s M e d i c a l U n i v e r s i t y , s u c h i n v e s t i g a t i o n s a n d e d u c a t i o n , w h i c h a r e e s s e n t i a l i n t h e p r e c i s i o n m e d i c i n e i n c l u d i n g g e n o m e m e d i c i n e , a r e c a r r i e d o u t . F u r t h e r m o r e , i n t h e A f f i l i a t e d F i e l d o f M e d i c a l G e n e t i c s l o c a t e d i n t h e I n s t i t u te o f M e d i c a l G e n e t i c s , w e h o l d t r a i n i n g p r o g r a m f o r “ t h e C l i n i c a l G e n e t i c i s t s ” a n d “ C e r t i f i e d G e n e t i c C o u n s e l o r s ” t o p r o v i d e c l i n i c a l g e n e t i c m e d i c i n e i n h i g h q u a l i t y . I n t h o s e p r o g r a m s , c r e d i t t r a n s f e r s y s t e m i s i n d u c e d i n c o o p e r a t i o n w i t h O c h a n o m i z u U n i v e r s i t y G r a d u a t e C o u r s e .
GENE MEDICINE
Research1 . C o r r e l a t i o n b e t w e e n c l i n i c a l m e d i c i n e a n d g e n o m e i n g e n e t i c d i s e a s e s ( N e u r o m u s c u l a r d i s o r de r s , h e mat or o g i c a l d i s e a s e s , D i a b e t e s m e l l i t us , F a mi l i a l c a n c e r , C a r d i ov a s c u l a r d i s e a s e , M u l t i f a c to r i a l d i s e as e s )2 . G e n e t i c c o u n s e l i n g ( G e n e t i c t e s t i n g , P r e n a t a l d i a g n o s i s , P r e s y m p to m a t i c d i a g n o s i s )
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GENE MEDICINE
3 . S t u d y o n e t h i c s o f g e n e t i c t e s t i n g4 . P h a r m a c o g e n o m i c s5 . A n a l y s i s o f b i o m a r k e r i n s p i n a l m u s c u l a r a t r o p h y6 . I n v e s t i g a t i o n o f n e w m e t h o d s o f t r e a t m e n t i n g e n e t i c i n t r a c t a b l e d i s e a s e s7 . T h e o r y a n d p r a c t i c e o f g e n e t i c s t a t i s t i c s
publication
Faculty K a y o k o S a i t o , P r o f e s s o r ( S p e c i a l A p p o i n t m e n t ) , D i r e c t o r T o s h i y u k i Y a m a m o t o , A s s o c i a t e P r o f e s s o r M a r i M a t s u o , A s s i s t a n t P r o f e s s o r R e i k o A r a k a w a , A s s i s t a n t P r o f e s s o r H i t o s h i K a n n o , P r o f e s s o r A t s u o T a n i g u c h i , P r o f e s s o r N a o k o I w a s a k i , A s s o c i a t e P r o f e s s o r Y o s h i k a A k i z a w a , A s s i s t a n t P r o f e s s o r A k e m i Y a m a u c h i , A s s i s t a n t P r o f e s s o r ( P a r t t i m e ) E r i K o n d o , A s s i s t a n t P r o f e s s o r ( P a r t t i m e ) M a y u r i I t o , A s s i s t a n t P r o f e s s o r ( P a r t t i m e ) Y u j i K u b o , A s s i s t a n t P r o f e s s o r ( P a r t t i m e ) T o s h i t a k a U c h i y a m a , A s s i s t a n t P r o f e s s o r ( P a r t t i m e ) M a s a y uk i A r a k a w a , A s s i s t a n t P r o f e s s o r ( P a r t t i m e )
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About usO r g a n r e p l a c e m e n t s , s u c h a s o r g a n t r a n s p l a n t s , a r t i f i c i a l h e a r t s o r d i a l y z e r s , a r e w i d e l y u t i l i z e d i n t h e c l i n i c a s t r e a t m e n t s f o r p a t i e n t s w i t h f u n c t i o n a l d e c l i n e o r l o s s o f f u n c t i o n o f o r g a n s . F u r t h e r m o r e , t h e r e s e a r c h a n d d e v e l o p m e n t f o r c r e a t i n g t i s s u e s a n d o r g a n s f r o m c e l l s h a s a c c e l e r a t e d d u e t o r e c e n t a d v a n c e s i n r e g e n e r a t i v e m e d i c i n e .T h e p r i m a r y a i m o f o u r f i e l d i s t o r e s e a r c h a n d d e v e l o p n e w c u t t i n g - e d g e o r g a n r e p l a c e m e n t s . W e s e e k t o c r e a t e a l l k i n d s o f m e d i c a l m a t e r i a l s i n c l u d i n g b i o c o m p a t i b l e m a t e r i a l s , a s b i o m a t e r i a l s a r e a f u n d a m e n t a l c o m p o n e n t o f t h i s w o r k . W e a l s o a r e d e v e l o p i n g n e w m e t h o d s f o r n e x t g e n e r a t i o n o r g a n c r e a t i o n , i n c l u d i n g h i g h - t h r o u g h p u t c e l l c u l t u r e , s c a l e d - u p v a s c u l a r n e t w o r k f o r m a t i o n , c e l l / o r g a n c u l t u r e t h r o u g h u s e o f b i o r e a c to r s , a n d f u r t h e r t e c h n i c a l d e v e l o p m e n t o f r e l a t e d d e v i c e s t o p e r f o r m t h e s e m e t h o d s .
ORGAN REPLACEMENT
Research( 1 ) F a b r i c a t i o n o f 3 D t i s s u e s / o r g a n s b a s e d o n c e l l s h e e t t e c h n o l o g y( 2 ) F a b r i c a t i o n o f h u m a n t i s s u e s / o r g a n s( 3 ) T e c h n i c a l d e v e l o pm e n t t o e n g i n e e r s k e l e t a l m u s c l e t i s s ue( 4 ) R e g e n e r a t i v e m e d i c i n e f o r k i d n e y d i s e a s e( 5 ) T e c h n i c a l d e v e l o pm e n t f o r t i s s u e / o r g a n f a c t o r i e s( 6 ) B i o - i n t e r f a c e s f o r c r e a t i o n o f s u b s t i t u t i o n a l o r g a n s( 7 ) E n g i n e e r i n g o f t i s s u e s h a v i n g c o m p l e x s t r u c t u r e / f u n c t i o n u s i n g m i c r o - f a b r i c a t i o n t e c h n i q u e s( 8 ) D e v e l o p m e n t o f n e w t r e a t m e n t s w i t h a r t i f i c i a l o r g a n s
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ORGAN REPLACEMENT
publication
Faculty T a t s u y a S h i m i z u M i c h i o M i n e s h i m a K a t s u h i s a M a t s u ur a M a s a m i c h i N a k a y a m a Y o s h i k a t s u A k i y a m a J u n K o b a y a s h i H i d e k a z u S e k i n e Y u j i H a r a g u c h i S h i n a k o A o k i S a c h i k o S e k i y a H i r o n o b u T a k a h a s h i T e t s u t a r o K i k u c h i D a i s u k e S a s a k i J u n H o m m a
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About usD o n o r t r a n s p l a n t a t i o n h a s b e e n t h e d e f i n i t i v e t r e a t m e n t f o r s e v e r e d i s e a s e s , b u t i s l i m i t e d b y a l a c k o f d o n o r s a n d t h e n e e d f o r i m m u n o s up pr e s s a n t d r u g a p p l i c a t i o n a f t e r t r a n s p l a n t a t i o n . G l o b a l i n t e r e s t h a s t u r n e d t o r e g e n e r a t i v e m e d i c i n e a n d t i s s u e e n g i n e e r i n g t o p r e s e n t n e w s o l u t i o n s t o t h e s e p r o b l e m s .T i s s u e e n g i n e e r i n g w a s p r o p o s e d i n 1 9 9 3 b y R o b e r t L a n g e r , a n A m e r i c a n e n g i n e e r , a n d J o s e p h V a c a n t i , a n A m e r i c a n s u r g e o n , w h o p r o v e d t h a t t h e r e g e n e r a t i o n o f t h e t h r e e‐d i m e n s i o n a l t i s s u e s t r u c t u re i s f e a s i b l e b y a d d i n g c e l l s t o a b i o d e g r a d a b l e p o l y m e r i n t h e p r e s e n c e o f g r o w t h f a c t o r s . T h e f u r t h e r p a r a l l e l d e v e l o p m e n t o f t i s s u e e n g i n e e r i n g a n d c e l l b i o l o g y i s e x p e c t e d t o p r o g r e s s .R e g e n e r a t i v e m e d i c i n e i s i n t e r d i s c i p l i n a r y , a c h i e v i n g m o r e t h a n m e d i c a l s c i e n c e o r e n g i n e e r i n g a l o n e . T h i s r e s e a r c h f i e l d i n t e g r a t e s m e d i c i n e , s c i e n c e a n d e n g i n e e r i n g t o p r o v i d e i n n o v a t i v e , n e w c o n c e p t s a n d a p p r o a c h e s f o r t h e f u t u r e d e v e l o pm e n t o f m e d i c i n e .
TISSUE REGENERATION
Research( 1 ) T e c h n i c a l d e v e l o pm e n t o f i s o l a t i o n / d i f f e r e n t i a t i o n / a m p l i f i c a t i o n o f s t e m c e l l s( 2 ) R e g e n e r a t i v e t h e r a p y w i t h c e l l s h e e t e n g i n e e r i n g( 3 ) D e v e l o p m e n t o f n e w r e g e n e r a t i v e t r e a t m e n t u s i n g m e s e n c h y m a l s t e m c e l l s h e e t( 4 ) A p p l i c a t i o n o f c u l t u r e e p i t h e l i a l c e l l s t o r e g e n e r a t i v e m e d i c i n e
FacultyM a s a y uk i Y a m a t o T a k a n o r i I w a t aK a t s u h i s a M a t s u ur a K a o r u W a s h i oN o b u o K a n a i S h i n a k o A o k iR y o T a k a g i M a m i K o k u b o publication
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About usT h e f i e l d o f I n t e g r a t e d M e d i c a l S c i e n c e s w a s e s t a b l i s h e d w i t h i n t h e A d v a n c e d B i o m e d i c a l S c i e n c e M a j o r o f t h e G r a d u a t e S c h o o l o f M e d i c i n e , T o k y o W o m e n ’ s M e d i c a l U n i v e r s i t y , w i t h a f o u n d a t i o n o f I n t e r n a t i o n a l R e s e a r c h a n d E d u c a t i o n a l I n s t i t u t e f o r I n t e g r a t e d M e d i c a l S c i e n c e s ( I R E I IM S) b y t h e f u n d o f P r o g r a m f o r P r o m o t i n g t h e E s t a b l i s h m e n t o f S t r a t e g i c R e s e a r c h C e n t e r s , S p e c i a l C o o r d i n a t i o n F u n d s f o r P r o m o t i n g S c i e n c e a n d T e c h n o l o g y , M i n i s t r y o f E d u c a t i o n , C u l t u r e , S p o r t s , S c i e n c e a n d T e c h n o l o g y ( J a p a n ) o n 2 0 0 6 . I n o u r f i e l d o f I n t e g r a t e d M e d i c a l S c i e n c e s , w e c o n d u c t r e s e a r c h o n m e d i c a l s c i e n c e s b y m e a n s o f i n t e g r a t i o n o f b a s i c s c i e n c e s a n d c l i n i c a l m e d i c a l r e s e a r c h . O u r m a i n f o c u s i s o n e l u c i d a t i o n o f m o l e c u l a r m e c h a n i s m s o f d i s e a s e s a n d i t s a p p l i c a t i o n t o d e v e l o p m e n t o f n o v e l a n d e f f i c i e n t m e d i c a l p r o c e d u re s f o r p r e v e n t i o n , d i a g n o s i s , a n d t r e a t m e n t o f d i s e a s e s . A l t h o u g h t h e r e h a v e b e e n m a n y f r u i t s o f b a s i c r e s e a r c h t o u n d e r s t a n d t h e d i s e a s e m e c h a n i s m s s o f a r , t h e s e f r u i t s m a y n o t h a v e b e e n w e l l a p p l i e d t o m e d i c a l p r a c t i c e , w h i c h i s o f t e n c a l l e d ‘ t h e v a l l e y o f d e a t h ’ t h a t m e a n s a g a p b e t w e e n b a s i c r e s e a r c h a n d c l i n i c a l m e d i c i n e . T h e g a p i s r e g a r d e d a s a b i g p r o b l e m f o r m e d i c a l r e s e a r c h t o d a y , t h e r e f o r e , t r a n s l a t i o n a l r e s e a r c h t h a t b r i d g e s t h e g a p i s e s p e c i a l l y e n c o u ra g e d . O n t h e o t h e r h a n d , a r e v e r s e t r a n s l a t i o n t h a t m e a n s a n a p p l i c a t i o n o f p r o b l e m s f o u n d i n c l i n i c a l m e d i c i n e o n b a s i c r e s e a r c h i s a l s o i m p o r t a n t . I n I n t e g r a t e d M e d i c a l S c i e n c e s , w e p r o m o t e b i d i r e c t i o n a l t r a n s l a t i o n a l r e s e a r c h b r i d g i n g b a s i c s c i e n c e s a n d c l i n i c a l m e d i c i n e o n d i s e a s e s o f c a n c e r , l i f e s t y l e - a s s o c i a t e d , a n d c o n g e n i t a l a n o m a l i e s b y m e a n s o f a d v a n c e d m o l e c u l a r a n a l y z i n g t e c h n i q ue s e m p l o y i n g e q u i p m e n t s i n T o k y o W o m e n ’ s M e d i c a l U n i v e r s i t y I n s t i t u t e f o r I n t e g r a t e d M e d i c a l S c i e n c e s ( T I I M S ) t h a t w a s f o u n d e d a s a s u c c e s s o r o f I R E I I MS .
INTEGRATED MEDICAL SCIENCES
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INTEGRATED MEDICAL SCIENCES
Research1 ) T o u n c o v e r t h e m o l e c u l a r m e c h a n i s m s o f c a n c e r a n d i t s a p p l i c a t i o n t o d e v e l o p m e n t o f n o v e l m o l e c u l a r m e d i c i n e s C a n c e r i s a m o l e c u l a r d i s e a s e . S i g n a l i n g p a t h w a y s a r e m a j o r p l a y e r s i n p h e n o t y p e s o f t h e d i s e a s e . T h e p a t h w a y s f o r m v e r y c o m p l e x n e t w o r k s c o n s i s t e d o f m a n y m o l e c u l e s i n t e r a c t i n g e a c h o t h e r , w h e r e t h e r e r e m a i n s a b i g r o o m t o b e u n c o v e r e d . W e p u r s ue r e s e a r c h t o a n a l y z e t h e c o m p l e x m o l e c u l a r p a t h w a y s i n c a n c e r a n d i t s a p p l i c a t i o n t o d e v e l o p m e n t o f n o v e l m o l e c u l a r m e d i c i n e s u s e f u l f o r p r e v e n t i o n , d i a g n o s i s , a n d t h e r a p y o f t h e d i s e a s e .
2 ) E l u c i d a t i o n o f m o l e c u l a r m e c h a n i s m s o f d i s e a s e s b y m e a n s o f c o m p r e h e n s i v e g e n o m i c a n a l y s i s G e n e s i m p l i c a t e d i n d i s e a s e s h a v e b e e n i d e n t i f i e d b y l i n k a g e a n d a s s o c i a t i o n a n a l y s e s w i t h p o s i t i o n a l c l o n i n g o r c a n d i da t e g e n e a n a l y s e s . H o w e v e r r e c e n t l y , a m a j o r b r e a k t h r o u g h h a s b e e n t a k e n p l a c e b y d e v e l o p m e n t o f t h e m a s s i v e p a r a l l e l s e q u e n c e r t h a t e n a b l e s c o m p r e h e n s i v e w h o l e g e n o m e s e q u e n c i n g i n a s i n g l e i n s t i t u t i o n i n a m o d e s t c o s t . B y u s i n g t h i s h i g h - t h r o u g h p ut s e q u e n c e r a s w e l l a s o t h e r a d v a n c e d m o l e c u l a r a n a l y z i n g t e c h n i q u e s , w e c o n d u c t r e s e a r c h o n u n d e r s t a n d i n g m o l e c u l a r m e c h a n i s m s o f d i s e a s e s a n d e l u c i d a t e i n f o r m a t i o n u s e f u l f o r c l i n i c a l m e d i c i n e .
3 ) D i s e a s e p a t h o l o g i c a l s t u d i e s u s i n g d i s e a s e - s p e c i f i c i P S c e l l sS i n c e p a t i e n t s w i t h n e u r o g e n e t i c d i s o r de r s s u c h a s P a r k i n s o n d i s e a s e a n d A l z h e i m e r d i s e a s e s h o w b r a i n d y s f u n c t i o n s , b r a i n i m a g i n g i s o f t e n u s e d f o r c l i n i c a l d i a g n o s i s . F u r t h e r m o r e , m o l e c u l a r d i a g n o s i s i s o f t e n r e q u i r e d f o r t h e f i n a l d i a g n o s i s . H o w e v e r , d i s e a s e m e c h a n i s m i n t h e n e u r o n i s s t i l l u n k n o w n i n m o s t d i s o r de r s . T o o v e r c o m e t h i s d i l e m m a , w e a r e u s i n g d i s e a s e - s p e c i f i c i P S c e l l s . I n t h i s s t u dy , r a r e i n t r a c t a b l e n e u r o l o g i c a l d i s o r de r s a r e t h e t a r g e t p a t h o - p h y s i o l o g i c a l s t u d i e s .
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INTEGRATED MEDICAL SCIENCES
4 ) R e s e a r c h o n t h e c o n t e x t o f t h e g e n o m e c o p y n u m b e r a n d d i s e a s e s u s c e p t i b i l i t yT h e r e a r e s o m a n y g e n o m i c c o p y n u m b e r v a r i a t i o n s i n t h e h u m a n g e n o m e . S o m e o f t h e c o p y n u m b e r v a r i a t i o n s a r e r e l a t e d t o s p e c i f i c h u m a n d i s o r d e r s s u c h a s c o n g e n i t a l d i s o r d e r s a n d t h e d e v e l o p m e n t o f c a n c e r s . D i s e a s e s u s c e p t i b i l i t y o f t h e c o p y n u m b e r v a r i a t i o n s i s t h e t a r g e t o f t h i s s t u d y .
Faculty
T o s h i y u k i Y a m a m o t o . M D , P h D .A s s o c i a t e P r o f e s s o rE x p e r t i s e : M e d i c a l g e n e t i c sR e s e a r c h i n t e r e s t : C l i n i c a l s e q u e n c i n g , C h r o m o s o m a l m i c r o a r ra y t e s t i n g , d i s e a s e - s p e c i f i c i P S c e l l s , n e u r o l o g i c a l d i s o r de r , c o n g e n i t a l d i s o r de r
H i r o y u k i A k a g a w a . M D , P h D .A s s o i c a t e P r o f e s s o rE x p e r i e n c e : N e u r o s ur g e r y , N e u r o l o g y , G e n e t i c s , G e n o m i c s , B i o i n f o r m a t i c sR e s e a r c h i n t e r e s t s : S t r o k e , M o v e m e n t d i s o r de r s
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