graduate program in biomedical engineering · worcester polytechnic institute 4 sample program of...
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Graduate Program in
Biomedical Engineering
Ki Chon, PhDChair
Glenn Gaudette, PhDGraduate Program Director
Advisors
• BME core faculty
• For PhD & MS students
– Thesis/dissertation advisor will become
your department advisor
Worcester Polytechnic Institute
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Worcester Polytechnic Institute
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General Course Requirements• MS
– BME 6 credits
– Life Sciences 6 credits
– Math 6 credits
– Electives 6 credits
– Thesis 6 credits
• ME– BME 12 credits
– Life Sciences 6 credits
– Math 6 credits
– Electives 9 credits
• PhD– BME 12 credits
– Life Sciences 9 credits
– Math 6 credits
– Electives 12 credits
– Lab Rotations 6 credits
– Responsible Conduct of Science 1 credit
– Thesis 30 credits
Worcester Polytechnic Institute
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Sample Program of Study for
Instrumentation/Sensors • BME:
– BME523 Biomedical Instrumentation
– BME532: Medical Device Regulation
– BME581 Medical Imaging Systems
– BME4011 Biomedical Signal Processing
– DR or Thesis credit
– BME591 Graduate Seminar (Fall and Spring)
• Life Science Requirements:– BME562 Laboratory Animal Surgery
– BME560 Physiology for Engineers
– BME595C Cell & Molecular Biology for Engineers
• Math Requirements:– MA501 Engineering Mathematics
– MA511 Applied Statistics for Engineers and Scientists
– MA546 Design & Analysis of Experiments
• Others:– ECE503 Digital Signal Processing
– ECE4703 Real-Time Digital Signal Processing
• Other Electives:– MIS576 Project Management
Worcester Polytechnic Institute
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Sample Program of Study for
Biomedical Imaging• BME:
– BME581 Medical Imaging Systems
– BME582 Principles of In Vivo Nuclear Magnetic Resonance Imaging
– BME 4201 Biomedical Imaging
– BME532: Medical Device Regulation
– DR or Thesis credit
– BME591 Graduate Seminar (Fall and Spring)
• Life Science Requirements:– BME562 Laboratory Animal Surgery
– BME560 Physiology for Engineers
– BME595X Cell & Molecular Biology for Engineers
• Math Requirements:– MA501 Engineering Mathematics
– MA 511 Applied Statistics for Engineers and Scientists (1st choice)
– MA 540 Probability and Mathematical Statistics I
– MA 546 Design and Analysis of Experiments
• Others:– ECE 502 Analysis of Probabilistic Signals and Systems
– ECE 503 Digital Signal Processing
– ECE 545 Digital Image Processing
• Other Electives:– MIS576 Project Management
Worcester Polytechnic Institute
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Sample Program of Study for
Biomechanics/Biomaterials• BME:
– BME550 Tissue Engineering
– BME552 Tissue Mechanics
– BME554 Composites with Biomedical and Materials Applications
– BME558 Biofluids and Biotransport
– BME532: Medical Device Regulation
– BME595C: Cardiovascular Engineering & Regeneration
– BME4504 Biomechanics
– DR or Thesis credit
– BME591 Graduate Seminar (Fall and Spring)
• Life Science Requirements:– BME562 Laboratory Animal Surgery
– BME560 Physiology for Engineers
– BME595X Cell & Molecular Biology for Engineers
• Math Requirements:– MA501 Engineering Mathematics
– MA511 Applied Statistics for Engineers and Scientists
• Other Electives:– MIS576 Project Management
Worcester Polytechnic Institute
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Sample Program of Study for
Tissue Engineering• BME:
– BME550 Tissue Engineering
– BME554 Composites with Biomedical and Materials Applications
– BME532: Medical Device Regulation
– BME595C: Cardiovascular Engineering & Regeneration
– BME 4828 Biomaterial - Tissue Interactions
– DR or Thesis credit
– BME591 Graduate Seminar (Fall and Spring)
• Life Science Requirements:– BME562 Laboratory Animal Surgery
– BME560 Physiology for Engineers
– BME595X Cell & Molecular Biology for Engineers
• Math Requirements:– MA501 Engineering Mathematics
– MA511 Applied Statistics for Engineers and Scientists
• Other Electives:– MIS576 Project Management
Graduate School
• Work more independently than
undergraduate
• Produce your own work
• GPA > 2.75 to make satisfactory
progress
• GPA > or = 3.0 to graduate
• No more than 2 C grades
Worcester Polytechnic Institute
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Getting Around Gateway
• Access to Gateway is restricted – if
you need access see your advisor
• Visitor Parking lot on side of
Gateway
• Shuttle is available/SNAP after hours
• Jean Siequist is Graduate
Administrative Assistant (4th floor of
Gateway)
Worcester Polytechnic Institute
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Worcester Polytechnic Institute
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Kristen Billiar
Glenn Gaudette
Magnetic Resonance
Imaging
Bio-Instrumentation/
Biosensors
Tissue Engineering/
Biomaterials
K Helmer, 2005
Faculty
Christopher Sotak
Ki Chon
Don Granquist-Fraser
Yitzhak Mendelson
Ray Page
George Pins
Marsha Rolle
Tissue Engineering/
Biomechanics
Worcester Polytechnic Institute
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Adjunct/Associated Faculty
• Mechanical Engineering– Holly Ault
– Allen Hoffman
– Brian Savilonis
– Satya Shivkumar
– John Sullivan
• Electrical Engineering– Edward Clancy
– Fred Looft
– Peder Pederson
• Mathematical Sciences– Dalin Tang
• Chemical Engineering– Terri Camesano
• UMass Medical School– Matt Gounis
– Mitch Albert
– Mike King
– Ray Dunn
Worcester Polytechnic Institute
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Prof Chris Sotak
Biomedical ImagingDevelopment of magnetic
resonance imaging (MRI) methods
for evaluating acute stroke and its
response to therapy.
Development of MRI endpoints for
evaluating therapeutic efficacy in
pre-clinical models of cancer.
Development of novel MRI contrast
agents for targeted visualization of
specific biological processes.
Worcester Polytechnic Institute
Ki Chon, Ph.D.Ph.D., Univ. of Southern California, Biomedical Engineering
Post-doc, Harvard-MIT
Industry, Otis Elevator
Funding: NIH, Navy, Juvenile Diabetes Research Foundation
Research Interests: Development of noninvasive, predictive and diagnostic
health monitoring devices
– Atrial Fibrillation Detection
– Hypovolemia detection using pulse oximeter
– Diabetic
cardiac
neuropathy
detection
kDa
43
34
26
Actin
Synapto: C57 Akita
Prof. Don Granquist-FraserResearch Interests: BI3 →
Bio-Instrumentation, Imaging &Interface
Remote & Non-invasive Biometry
& Signal Acquisition
Novel Imaging Systems & Detectors
Phase Space Signal Source Separation
PROCESSEDRETURN
MICROWAVETRANSCEIVER
HORNANTENNAS
22 GHz REMOTE ECG SYSTEM
Worcester Polytechnic Institute
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Biomedical Engineering (1983) Ph.D. Case Western Reserve University.
Electrical Engineering (1976) M.Sc. State University of NY, Buffalo, NY.
Electrical Engineering (1975) B.Sc. State University of NY, Buffalo, NY.
EDUCATION:
Prof. Yitzhak Mendelson
TEACHING:
BME 3011 Bioinstrumentation and Biosensors
(Basic properties of biosensors and biomedical instrumentation)
BME 4011 Biomedical Signal Analysis
(Properties and processing of biomedical signals)
BME 4023 & BME 523 Biomedical Instrumentation Design(Design of biomedical instrumentation)
WEARABLE WIRELESS TELESENSORSRESEARCH:• Embedded Microcontrollers-Based Devices
• Physiological Signal Processing
Worcester Polytechnic Institute
Raymond Page, Ph.D.Ph.D. Virginia Tech, Chemical Engineering
Industry: PPL Therapeutics, Advanced Cell Technology, Cellthera
Funding: DSO/DARPA
Research Interests: Tissue regeneration using autologous cell therapy, cell phenotype
manipulation, delivery systems and functional monitoring.
– Cell de-differentiation
– Biomaterial micro-thread cell delivery systems
– In vivo transplantation/ functional monitoring
Surface Signaling
Biomaterial Scaffolds
0
2
4
6
8
10
12
14
16
0.5
00
0.7
55
1.0
10
1.2
65
1.5
20
1.7
75
2.0
30
2.2
85
2.5
40
2.7
95
3.0
50
3.3
05
3.5
60
3.8
15
4.0
70
4.3
25
4.5
80
4.8
35
5.0
90
5.3
45
5.6
00
5.8
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6.1
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6.3
65
Teta
nic
Fo
rce
(g)
Time (s)
Intermittent Stimulation
Non-Injured Injured
Worcester Polytechnic Institute
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Prof. George Pins
Research Interests: Biomimetic Scaffolds to
Enhance Tissue Regeneration
– Microtextured basal lamina analogs
– ECM-cell interactions
– Biopolymer microthreads
(Downing, JBMR, 72A: 47)
(Bush, JBMR, 80A: 47, Bush, JBMR, in press)
(Cornwell, JBMR, 82A: 104)
Worcester Polytechnic Institute
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Worcester Polytechnic Institute
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Prof Marsha Rolle
Cell-based vascular tissue engineering
• Generate living vascular tissue
models with cell self-assembly
• Mechanical and physiological testing
of engineered vascular tissue
• Molecular and genetic control of cell
phenotype and ECM synthesis
2 mm