gracewell product faq's & competetor knockouts

8/13/2019 Gracewell Product Faq's & Competetor Knockouts

1/25

ScalpeQ. 1 How does Scalpe score over Nizral?

Scalpe is a combination of Ketoconazole 2% and Zinc Pyrithione(ZPTO) 1%, hereas !izral of "#" is plain Ketoconazole 2%$

ZPTO has a synergistic action with Ketoconazoleandtoether there is s&perior f&nicidal action aainst P$ o'ale$

oreo'er there is &niform dispersion of ZPTO and Ketoconazolein Scalpe leadin to impro'ed cleansin of dandr&ff flaes andhih patient compliance$ The oa!ing a"ilityof Scalpe isbetter than that of !izral$

Scalpe form&lation also has higher viscositycompared to!izral$ There is &niform dosae of ZPTO thro&ho&t &sae ofScalpe$

The difference is in the e#tra conditioningoffered by Scalped&e to *+ide, *misoft, ocomonoethanolamide, ocobetaineand ocodiethanolamide$

Q. $ %s the co!"ination o Ketoconazole & ZPTO synergistic?

-es, the combination of Ketoconazole 2% and Zinc Pyrithione (ZPTO)1% is syneristic as e.plained in the diaram belo$

oreo'er, the chart f&rther e.plains the syneristic action of both fors&perior control of dandr&ff and seborrheic dermatitis$

ZPTO & Ketoconazole S'perior

!ormalizesepidermal&ltrastr&ct&re #decreases seb&msecretion

/*nti0androenicproperty

ontrol of e.cessseb&m

red&ceserythema,b&rnin # itchin

/anti0inflammatoryaction

relief from sinsand symptoms

e.cellentretenti'ity on

scalp # hair

/stron absorptionby eratin

pre'entsrec&rrence


2/25

Q.( %s the eicacy o Scalpe proven co!pared to plainKetoconazole or plain ZPTO?

There is one st&dy and abstract that has been presented at linicalermatoloy onference 2, 3ienna$ * randomized comparati'est&dy as done for 12 months in patients ith seborrhea capitis andthe c&re rates ere 45% ith Scalpe compared to +&st 4% ith

Ketoconazole and 67% ith ZPTO$

Q. ) *oes ZPTO have any role on hair growth?

-es, ZPTO has been clinically pro'en for its role on hair roth$ 8n ast&dy p&blished in 9ritish "o&rnal of ermatoloy 2:, sinificantincrease as obser'ed in total 'isible hair co&nts after 4 ees oftreatment$ There as modest and s&stained impro'ement in hair

roth ith daily &se o'er 2; ee period$+e ,r -. *er!atol $//( 0'g 1)23$4 (5)67$

Q. 5 8hat are the conditioners and s'ractants 'sed in Scalpe?

Scalpe offers a &ni

increases manaeability

Q. 7 *oes Scalpe oa! well d'ring wash?


3/25

Scalpe has e.cellent foamin ability as demonstrated in ?raph belo$8t scores o'er onadern (@anba.y) and !izral ("#")$ There is &niformdispersion of ZPTO and Ketoconazole in Scalpe leadin to impro'edcleansin of dandr&ff flaes and hih patient compliance$

Q. : 8hat is pH o Scalpe?

The pA of Scalpe is ;$1 > slihtly acidic pA, closer to normal sin pA$Th&s it is delicate to sin and hair$


4/25

;o!ate

1. 8hat are topical steroids and how do they wor


5/25

The folloin are f&rther e.amplesH

0rea o s


6/25

(. 8hich are the !a9or indications or ;o!ate?

). 8hat are the other indications where !o!etasone is "eing'sed "y der!atologists?

PD= Dichen plan&s Ayperpimentation in combination ith retinoids Post lasers # peels

:. 8ho are the !a9or co!petitors?

;olec'le ,randPac2m

Tice0daily dose$Once0daily dose isespecially beneficial inpediatric pop&lation forcomplianceJ

J"o&rnal of 8nternational

edical @easearch (16)H 7;07;5, 144

9etamethasoneipropionate

ipro'ate(@anba.y) (nochaned tobeclomethasone)rm01Gm

9etamethasone hascome &nder PO,therefore, ma+or brandsha'e chaned tobeclomethasone (lessefficacio&s)Tice0daily dosae

9etamethaso 9etno'ate (?SK) Tice0daily application

,rand %ndications *irections or >sage

omate ream*topic ermatitis,

ontact ermatitis,iaper ermatitis, 3itilio

Thin film of ometasone $1%cream or ointment sho&ld beapplied to the affected areas

once dailyomate Ointment Psoriasis,*topic ermatitis,

omate Dotion

*lopecia *reata,=czema in Aairy areas,

Scalp Psoriasis, Seborrhoeicermatitis

Dare s&rface areas,radle ap

*pply a fe drops to the affectedsin areas incl&din scalp sitesonce daily massae ently andthoro&hly &ntil the medication

disappears

omate0SDichenified sin lesions lie,

pla


7/25

ne3alerate

rm02m (ometasone is moreefficacio&s # safe)

lobetasone9&tyrate

=&mosone (?SK) Tice daily applicationnot con'enient forchildrenhildren s&fferin fromatopic dermatitis m&stbe treated ith

moderately potentform&lations 'ery mildform&lations are nots&ested beca&s7e ofthe hih incidence ofrelapse

@. Pac< sizes o !a9or ;o!etasone "rands

,+0N*S 3Ar!4 AO;P0NB 5g! 1/g! 15g! $/g! (/g!

=DOO! CBDCO@ 8!8* L

O*T= ?D=!*@K L L

AA0SO!= A # A L

OT*S CD L L

BT8ZO!= @*!9*M- L L

S D83* L L

OOZ B!8A= L L

2. +eerences or co!petition tac


8/25

!o clinical or histoloical sins of sin atrophy ere obser'ed in'ol&nteers after 12 months of once0daily application ofmometasone $1% cream$

ometasone has shon a lo ris of primary sensitisation andcross0reactions, e'en in patients non to be hypersensiti'e tol&cocorticoids$D

Aonvenience N8n addition to its lo potential for ca&sin primary sensitisation

and cross0reactions ith other topical l&cocorticoids,mometasone offers the con'enience of once0dailyadministration$

*r'gs 122@ -an 55 314 1)5617(

;o!etasone vs. =l'ticasone

ometasone f&roate ointment $1% as compared ith

fl&ticasone propionate ointment $G% in patients ithpsoriasis '&laris$ !o$ of patients2;2 Treatment for : ees @es&ltsH * statistically sinificant difference as seen in mean

percent impro'ement of total sinIsymptom se'erity by day 1G(p less than $1)$ 8n addition, by day 22 (end of treatment), a;;$6% impro'ement as noted in patients ho appliedmometasone 'ers&s G;$2% impro'ement in those ho &sedfl&ticasone (p less than $1)$

oncl&sonH ometasone as fo&nd to be more effecti'e than

fl&ticasone hen &sed in the treatment of psoriasis$

*e Eillez et alF 122@

;o!etasone vs. Alo"etasone

linical st&dy in children ith atopic dermatitis !o$ of patients ; Treatment period : ees @es&ltsH *t the end of the : ee st&dy period, mometasone as

sinificantly s&perior to clobetasone in red&cin the total sinand symptom se'erity score$ometasone 6;$1%lobetasone ;;$1%G% of mometasone0treated patients ere clear of symptomscompared ith ;$5% of the clobetasone treated ro&p

+aanelli 0F - C'r 0cad *er!atol venereal 122($3(4$$56(/


9/25

;o!etasone vs. Hydrocortisone

linical st&dy in children ith atopic dermatitis !o$ of patients 7; Treatment period ; ees @es&ltsH *t the end of the ; ee st&dy period, the o'erall mean

percent red&ction in sins and symptoms as 4G% ithmometasone and 5G% ith hydrocortisone$ !o instances ofadrenal s&ppression or dermal atrophy ere reported ith eitherdr&

Eernon et alF 1221

1/. Once6daily application vs. Twice6daily application

ometasone possesses an important therape&tic ad'antae in that itis effecti'e &sin once daily applications (especially beneficial in

pediatric pop&lation for compliance)

@ed&ces patientEs e.pos&re to dr&

@ed&ces ris of side effects

=.ceptionally fa'orable safety profile

-o'rnal o %nternational ;edical +easearch 31@4 )7/6)7:F122/

11. ,eneits o ;o!etasone in ;O;0TC with Propylene glycol"ase

Propylene lycol base ens&res loner contact time ith thelesions, lie an ointment, b&t itho&t the sticinessIreasyfeelin$

9etter penetration of the dr& into the lesions$ Bniform, e'en consistency and easy application$ Ayroscopic


10/25

Elovera

Product Differential

Contains most effective moisturizer, i.e., Aloe vera, hence superior re-hydrating

activity.

Oil in water cream; provides high moisture content to complement emollient

action.

on-greasy ! cosmetic elegance

p" #.#; natural p" of the s$in.

%imethicone& 'mulsifiers ! consistency modifiers; for smooth spreada(ility

)ragrance and colour free; hence no ris$ of allergy

*teroid sparing; can (e mi+ed with topical steroids to reduce their uantities

What is the best time to apply Elovera?

'lovera creamlotion should always (e applied after a shower or (ath while the

s$in is still moist. refera(ly within /-# minutes.

0his will help to loc$ moisture.

What make Elovera cream ideal for patients with sensitive skin?

'lovera cream is free from colors and perfumes. 'lovera cream also matches s$in

p" of #.#.

Elovera Cream Vs Moisturex Cream

Elovera Cream Moisturex CreamAloe vera ! 1itamin ', Allantoin !

2lycerine (ase

3rea, lactic acid, ropylene glycol, light

liuid paraffin

Aloe vera provide effective moisturization

with added anti-inflammatory, anti-pruritic

(enefits

o Aloe vera present

%ecreases 0'456 Contains 3rea, which can increase 0'456

p" is #.# ot revealed

on-2reasy 2reasy

)ragrance free 3npleasant fragrance

ac$ options of #7g ! 8#7g 9#g ! :#g


11/25

Elovera Cream Vs Cotaryl Cream

Elovera Cream Cotaryl CreamAloe vera ! 1itamin ', Allantoin !

2lycerine

3rea, lactic acid, glycine, Ammonium

chloride, *odium chloride


with added anti-inflammatory, anti-pruritic(enefits

o Aloe vera present

%ecreases 0'456 Contains 3rea, which can increase 0'456p" is #.# ot revealed

on-2reasy 2reasy

1anishing cream (ase o vanishing cream (ase


ac$ options of #7g ! 8#7g #7gm

Elovera Cream Vs Dermadew Cream

Elovera Cream Dermadew CreamAloe vera provide effective moisturization


Aloe vera present


'lovera contains finest uality grade of

Aloe vera, certificate of analysis from

)rance

uality source not $nown

p" is #.# ot revealed

on greasy 2reasy

ac$ options of #7g ! 8#7g #7gm

Elovera Cream Vs Cetaphil Cream

Elovera Cream Cetaphil CreamAloe vera ! 1itamin ', Allantoin !

2lycerine (ase

cetyl alcohol

stearyl alcohol



o Aloe vera present

on greasy 2reasy

p" is #.#


12/25

Elovera Moisturiin! "ody Wash #$%What is differential positionin! of Elovera Moisturiin! "ody wash & Episoft?

'lovera ?@4 is a moisturizing (ath therapy containing Colloidal oatmeal !

Aloe vera, whereas 'pisoft is a cleansing lotion containing Cetearyl alcohol,

Cetostearyl alcohol ! @utylene glycol

'lovera ?@4 offers gentle cleansing, moisturizing ! Anti-inflammatory

(enefits whereas 'pisoft offers gentle cleansing

@oth can co-r+ed

Elovera M"W Episoft )or %ry s$in )or *ensitive s$in

n A%, Berosis ! chthyosis Also in "and eczema ! post

retinoiddryness

n Atopic %ermatitis

All over @ody ?ainly for )ace

'ow Colloidal oatmeal protects & moisturies skin?

Colloidal oatmeal (inds to the s$in ! forms protective layer

?oisturizes ! softens s$in naturally elieves from itching ! irritation

What is the difference between oatmeal and colloidal oatmeal?

0he term DcolloidalD simply means very small, in other words, that the

oatmeal has (een ground into e+tremely fine particles.E Colloidal oatmeal is made of tiny particles of Oatmeal that are distri(uted

evenly throughout the continuous phase.

0he size of the dispersed phase particles are (etween 8nm and 8777nm sothat a eual dispersion and spreada(ility can (e o(tained

Can a Moisturier be applied alon! with the Elovera "ody wash?

Fes, 'mollient and ?oisturizer (oth can (e applied after @ath with

'lovera ?@4

0his will add to the (enefit and will further prevent the loss of moisture.

What is importance of (kin p'?

0he p" of normal, healthy human s$in is somewhere (etween )*+ and ,* 4hen in (alance, the com(ined e+cretion of oil and sweat from the s$inGs

pores has a p" of a(out +*+* Also referred to as the HAcid ?antleE, is our (odyGs first defense

mechanism against (acteria invasion

0his is our (odyGs way to increase our defense system.

-he acid mantle. supports the formation and maturing of epidermal lipids and therefore

the maintenance of the (arrier function and thus prevents loss of moisture. provides indirect protection against invasion (y microorganisms.

provides direct protection against al$aline su(stances


13/25

4e have used sodium 5auroamphoacetate, a mild cleansing and lathering

agent. Cocoamidopropyl @etaine which is an amphoteric surfactant also

has less irritation. 0hese are mild (ecause these cleansers are used in very small uantity and

with less concentration

'ow Elovera Moisturiin! "ody wash superior to re!ular body wash?

"igher dry s$in relief in single application "igher itch relief

/s Elovera Moisturiin! "ody wash clinically proven? /s there any /ndian reference?

'lovera ?oisturizing @ody wash scores highly in irritancy ran$ing study of /8

cleansers in the ndian mar$et8

5east irritant cleanser 5owest scaling score of zero

*$in friendly p" I

eference& 8. nternational Journal of Cosmetic *cience, 977K, /7, 9::9K/

Why combination of oatmeal and aloe vera?

0o give a dual (enefit to the patients

As in dry s$in disorders, there is an association of itching, inflammation,

rash. 0he com(ination of oatmeal and Aloe 1era solves all the a(ove said

pro(lems.

Aloe vera provides moisture directly to the s$in with softening, healing,anti-micro(ial, and anti-inflammatory properties.

4hereas, Colloidal oatmeal protects s$in and provides temporary relief ofitching and irritation ! also moisturizes s$in at the same time

Aair7B


14/25

1$ ino.idil / *mine.il combination is not stableQ *nsH *n international combination of G % ino.idil and 1$G% amine.il isa'ailable as

SPCAT+0G *NA "y *S Ga"oratoriesF %nc.A*8@ 7B has beenade


15/25

8t also impro'es the n&trition to the hair andth&s helps in impro'in the


16/25

sliht difference is beca&se Aair7B also contains additional benefitof

ino.idil$

6$ 8s amine.il efficacy clinically pro'enQ*nsH *mine.il is clinically pro'en to be effecti'e in taclin perifollic&lar

fibrosis,increasin anaen hair # decreasin teloen hair$ *lso *mine.il

has pro'enrole to increase hair roth and increase density and


17/25

4$ Rhat is the importance of AP baseQ*nsH Aydro.y propyl cell&lose base is a bio adhesi'e polymer base$ The

ad'antae of this base in hair7& is that there is no e'aporation of

the dr& once applied on to the scalp$ There is no mino.idil precipitation andcrystallization$ The dr& remains in sol&tion form and loner

contact timeith scalp leadin to better absorption, loner d&ration of action

and th&s better efficacy$

*ccordin to the trials > ino.idil is absorbed from the siteof application as lon as it remains in sol&tion$ So to prolon time ofabsorption,

bio adhesi'e polymer base is &sed in Aair7B$

1$ 8s amine.il / mino.idil syneristic combinationQ*ns H -es, amine.il / ino.idil is a syneristic combination for treatmentof

*ndroenetic *lopecia$0 ino.idil stim&lates hair roth by more than one mechanism H

they incl&deH direct sti!'lation o the hair olliclecells toenter into a proliferati'e phaseH resting phase 3telogen4

ollicles "eing sti!'lated to pass into active phase(anaen)follicles alteration o the eect oandrogens on geneticallypredeter!ined hair ollicles$ ino.idil may affect the androenmetabolism in the scalp by inhibitin the capacity of androens toaffect the hair follicles$

0 Perifollic&lar Cibrosis is a condition that accompanies all alopeciahereby the collaen aro&nd the hair root becomes riid andtihtens, p&shin the root to the s&rface and ca&sin premat&rehair loss$ *mine.il has been shon to increase hair density andhair roth by pre'entin perifollic&lar fibrosis$

0 Aence this combination pro'ides syneristic action to i'e root to

tip re+&'enation


18/25

eri'a S # eri'a S

11$ Rhat is the need of S TechnoloyQ*nsH 8t is ell doc&mented in many trial cond&cted that topical retinoidca&ses

irritation lie H erythema, b&rnin, scalin # itchin in laren&mber of

patients ith acne hich leads to compromised patient complianceandaffects treatment in acne$

To address the same concerns ofdermatoloists

across 8ndia ?lenmar as a leadin dermatoloy company,inno'ated the

already e.istin adapalene to mae adapalene in microspheretechnoloy in

eri'a S red&ces irritation and leads to better patient complianceleadin to

better efficacy$

12$ Ao icrosphere technoloy in eri'a S lead to betterefficacyQ

icrosheres are small inert particles that encaps&late e'en smalleradapalene

particles ithin it$ &e to trier factors lie r&bbin, pressin the adapalene isreleased on to

the sin in a s'stained !anner, leadin to adeI'ate conc. atthe

pilose"aceo's 'nitfor loner d&ration leadin to lon lastins'perior

eicacy

1:$ Ao does microsphere adapalene in eri'a S scores o'ercon'entional adapaleneQ

*ns H icrosphere adapalene scores o'er con'entional adapalene bypro'idin

better tolerability th&s increasin patient compliance therebyleadin to

enhanced efficacy in the treatment of acne '&laris$ icrosphere adapalene has been e'al&atedon 'ario&s

parameters as compared to con'entional adapalene$ icrosphere

adapalene


19/25

leads to red&ced b&rnin,erythema, scalin and itchin ascompared to

con'entional adapalene (as per microsphere adapalene paperpresentation

at =*3 Paris) Poster presentation st'dy

17$ Rhat is the correct method of application of adapaleneQ*ns H The correct method of application of eri'a S is hole faceapplication$

Tae small amo&nt on the finer and spread it e'enly all o'erthe

face$ *'oid application in periorbital and perioral areas$ *'oidcontact

ith eyes$

1G$ an eri'a S be &sed as maintenance therapyQ

*nsH eri'a can be effecti'ely &sed for maintenance therapy beca&se H0 it red&ces both inflamed and non inflamed lesions0 =.cellent impro'ement obser'ed ith prior combination

treatment0 ontrols microcomedones after combination treatment0 no ris of enhancin P$acnesresistance0 ith microsphere technoloy there is red&ced irritation0

1;$ Ao does eri'a S scores o'er tretinoinQ*ns H eri'a S scores o'er Tretinoin as there is red&ced irritationobser'ed

ith adaplene as compared to e'en tretinoin inmicrospheres$*dapalenecan be effecti'ely applied as maintenance therapy after

treatment ithcombinations$


20/25

15$ Ao does S technoloy help in eri'a SQ*ns H 8n eri'a S , adapalene in microsphere technoloy helps in

red&cin irritation th&s helps in impro'in patient compliance and th&sincreases

s&ccess of the treatment in inflammatory acne$ !ot only this ith microspheresadapalene

enhances penetration of clindamycin in the pilosebaceo&s &nitth&s leadin

to increased efficacy of the combination$

16$ Ao combination of *dapalene / lindamycin scores o'er plainlindamycin in the treatment of inflammatory acneQ

0 *cne lobal alliance recommends that in the treatment of acnecombinin topical retinoids ith an antimicrobial aent tarets: pathoenic factors, and clinical trials ha'e shon thatcombination therapy res&lts in sinificantly faster and reaterclearin as opposed to monotherapy$

0 8n eri'a SH microsphere adapalene mod&lates cell&lardifferentiation and e.erts anti 0 proliferati'e action$lindamycin in eri'a S pro'ides bactericidal action to illP$acnes$

0 *dapalene / lindamycin toether pro'ides d&al anti 0inflammatory action

0 9esides microsphere adapalene enhances penetration oflindamycin in the pilosebaceo&s &nit

0 8n a clinical trials cond&cted it is pro'ed that combination of*dapalene$1% / lindamycin 1% deli'ered a faster ands&perior response as compared to lindamycinalone.


21/25

14H hat is the patent stat&s of icrosphere technoloyQ

*nsH icrosphere technoloy has been &sed s&ccessf&lly in 'ario&sind&strial applications$ 9&t adapalene in microsphere technoloy is thein ho&se inno'ation of ?lenmar @#$Patent application has been filedto patent this inno'ati'e deli'ery system of adapalene in microspheretechnoloy by ?lenmar

%so"est

1. %so"est pac


22/25

(. %sotretinoin advantage over alternate therapies or severeacne

TherapySyste!ic

Keratolyticco!edolyti

c

0nti6!icro"ia

l

0nti6inla!!ator

y

Se"o6s'ppressive

%sotretinoin Stron oderate oderate Stron

Oralanti"iotics Rea Stron oderate !one

Oralcontraceptiv

eoderate !one !one Stron

SoF isotretinoin !eets all the ) para!eters or severe acnetherapy$ @eference also s&ests that isotretinoin i'es hihers&ccess rates than other therapiesH

St&dy 1$

The clinical efficacy of isotretinoin and minocycline, in 27 men ithse'ere cystic acne ere compared$ *t the end of treatment isotretinoinas sinificantly more effecti'e than minocycline and ind&cedremission in all s&b+ects$

St&dy 2$Tetracycline G m PO daily initially, increasin to 1 m daily, asreported as effecti'e as isotretinoin 1 mIIday PO initially, increasinto a ma.im&m of 2 mIIday PO, in the treatment of resistantnod&locystic acne in : patients in a controlled st&dy (Dester et al,

146G)$ Aoe'er, 6 ees after ithdraal of treatment, contin&ed andsinificant impro'ement occ&rred in isotretinoin0treated patients,hereas tetracycline0treated patients had either stabilized or relapsed$

C#pert Opin Phar!acother.$//( -'l)3:41/2:61/(

*cne patients sho&ld, here appropriate, be prescribed isotretinoinsooner rather than later$ 8t normally res&lts in complete clearance ofnod&locystic acne folloed by proloned remission and many patientsremain free from the disease$

Sheth +F Poonevala E. %ndian - *er!atol Eenereol Geprol $//17:1@/6$

). %ndications +eco!!endations o the Llo"al 0lliance

Se'ere nod&locystic acne and its 'ariants 8nflammatory acne ith scarrin oderate to se'ere acne &nresponsi'e to treatment ithH

o Three months of combination treatment incl&din systemic

cyclines


23/25

o Co&r cycles of anti0androen containin hormonaltreatment

*cne ith se'ere psycholoical distress ?ram0neati'e follic&litis Cre


24/25

1. How is =l'cort "ase 'niI'e?

Cl&cort has C*P? (Catty *cid Propylene ?lycol) base hich offersfolloin ad'antaesH

0 9etter penetration0 9etter local bioa'ailability0 8t has ad'antae of both cream # ointment base (ream0lieH !on0

reasy, cosmetically ood # hydrophilic$ Ointment0lieH occl&si'eAydrobhobic)

$. 8hat !a


25/25

antif&nal main Cl&cort0 an ideal steroid # antif&nal combinationfor f&nal infections ith inflammation$

gracewell product faq's & competetor knockouts

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