gpcr edition – week 1
DESCRIPTION
GPCR Edition – Week 1. Amino Acid Structure. Amino Acids: Misc. GPCR Structure. Chemical Interactions. Protein Secondary & Tertiary Structure. Potpourri. 100. 100. 100. 100. 100. 100. 200. 200. 200. 200. 200. 200. 300. 300. 300. 300. 300. 300. 400. 400. 400. 400. 400. - PowerPoint PPT PresentationTRANSCRIPT
GPCR Edition – Week 1
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Amino Acid
Structure
Amino Acids: Misc.
GPCR Structure
Chemical Interactio
ns
Protein Secondary & Tertiary Structure
Potpourri
GLYCINE
VALINE
CYSTEINE
Histidine
TRYPTOPHAN
THE AMINO ACID ARGININE HAS THIS
GROUPING OF AMINO ACIDS, ALONG WITH
LYCINE AND HISTIDINE (IF THE PH IS JUST
RIGHT)POSITIVELY CHARGED
THIS AMINO ACID CAN BE ABBREVIATED AS
“GLN” OR “Q”
GLUTAMINE
THE AMINO ACID ARGININE IS
ABBREVIATED AS “ARG” AS WELL AS THIS ONE LETTER
R
“ALPHA” REFERS TO THIS ELEMENT THAT IS COVALENTLY BONDED TO AN AMINO GROUP, A CARBOXYL GROUP, A
HYDROGEN, AND A SIDE CHAIN
CARBON
THIS NUMBER IS THE NET NEGATIVE OR
POSITIVE CHARGE OF THE FOLLOWING
SHORT OLIGOPEPTIDE:DEKHR
+1
GPCRS ARE ALSO KNOWN AS
HETPAHELICAL RECEPTORS, MEANING
THEY HAVE THIS NUMBER OF ALPHA
HELICESSEVEN
PHOSPHOLIPID
GPCRS ARE EMBEDDED INTO A
MEMBRANE BILAYER COMPOSED OF THIS TYPE OF BIOLOGICAL
MOLECULE
GPCRS ARE VERY DIFFICULT TO
CRYSTALLIZE AND OFTEN TIMES HAVE
CRYSTALLIZATION “HANDLES” FUSED TO
THEM. THIS ONE IS SIMILAR TO WHAT WE
USED IN OUR EXPERIMENT.T4 LYSOZYME
THIS CLASS OF GPCRS HAS A LARGE
EXTRACELLULAR DOMAIN WITH A
“VENUS-FLYTRAP” STRUCTURE WHERE
LIGANDS BINDCLASS C
CLASS A GPCRS HAVE THIS CONSERVED
SEQUENCE MOTIF OF THREE AMINO ACIDS
THAT MEDIATES COUPLING TO G
PROTEINSDRY, ASP-ARG-TYR
THE ATTRACTION OF A CATION TO AN ANION IS REFERRED TO AS THIS
TYPE OF NON-COVALENT CHEMICAL
INTERACTIONIONIC/
ELECTROSTATIC
HYDROGEN BOND
THE NON-COVALENT INTERACTION SHOWN
HERE
THIS NON-COVALENT IS WHAT DRIVES NON-POLAR AMINO ACIDS
TO ORIENT THEMSELVES
TOWARDS THE INTERIOR OF A
PROTEIN AND AWAY FROM WATERHYDROPHOBIC
EFFECT
CARBOXYL
A PEPTIDE BOND IS A COVALENT CHEMICAL
INTERACTION BETWEEN THE AMINO GROUP OF ONE AMINO ACID AND THIS GROUP
OF THE OTHER
HYDROGEN BONDING BETWEEN THE CARBONYL
OXYGEN AND AMINO GROUP HYDROGEN OF TWO AMINO ACIDS 4 RESIDUES APART STABILIZES THIS TYPE OF
STRUCTUREALPHA HELIX
DAILY DOUBLE
THIS IS THE SIMPLEST ARRANGEMENT A
POLYPEPTIDE CHAIN CAN MAKE IN TERMS
OF SECONDARY STRUCTURE
ALPHA HELIX
THIS AMINO ACID’S RIGIDITY RESULTS IN ITS LOW PROBABILITY OF BEING FOUND IN
AN ALPHA HELIX
PROLINE
THE PARTIAL POSITIVE AND NEGATIVE CHARGE OF AN ALPHA HELIX N- AND C-
TERMINUS, RESPECTIVELY, IS REFERRED TO AS THIS
HELIX DIPOLE
THIS IS THE NAME OF THE CHART THAT MEASURES THE PROBABILITY OF
PARTICULAR PSI AND PHI ANGLES TO BE
FOUND IN SECONDARY STRUCTURERAMACHANDRAN
THIS PROTEIN STRUCTURAL MOTIF IS
NAMED AFTER A COMMON
ARCHITECTURAL DESIGN FOUND IN THE
HELLENIC REPUBLICGREEK KEY MOTIF
THIS LEVEL OF PROTEIN STRUCTURE IS THE
ARRANGEMENT OF 2 OR MORE SEPARATE
POLYPEPTIDE CHAINS (SUBUNITS)
QUATERNARY
GPCRS ARE COMPOSED PRIMARILY
OF THIS TYPE OF SECONDARY STRUCTURE
ALPHA HELIX
THE FUNCTIONAL AND FOLDED STRUCTURE OF A PROTEIN IN ITS
NORMAL ENVIRONMENT IS KNOWN AS THIS
NATIVE CONFORMATION
THE FORMATION OF A PEPTIDE BOND BETWEEN
TWO AMINO ACIDS RESULTS IN THE
CREATION OF THIS MOLECULE, WHICH IS WHY THE REACTION IS
CALLED CONDENSATIONWATER
WHICH UNIVERSITY IS THE ONLY ONE IN NCAA HISTORY TO
HOLD THE NATIONAL TITLE IN BOTH
BASKETBALL AND FOOTBALL?
UNIVERSITY OF FLORIDA