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Gout vs Pseudogoutby Group 3: Donnah,Bim,Mark,Ray

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• Gout and pseudogout are the 2 most common crystal-induced arthropathies

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• Gout is the result of increased uric acid in the body that causes crystallization that forms a type of fine crystals known as monosodium urate.

• On the other hand pseudogout is caused by the deposition of calcium pyrophosphate crystals in the synovial fluid of joints. Pseudogout is often referred to as Calcium Pyprophosphate Deposition Disease, CPPD.

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• Thus, what differentiates between gout and CPPD is the type of crystal deposits

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• Pseudogout usually occurs in individuals of age 50 and above.

• pseudogout tend to attack women more frequently while in the case of gout, it is men that dominate more 90 percent of the cases.

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• Reports show that pseudogout can occasionally coexist with gout. This means that both of those types of crystal can be found in the same joint fluid at times.

• Researchers have also noted that the cartilage is more calcified when both forms of deposits is found in a particular joint.

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• gout can be diagnosed by observing the symptoms of the affected joints and confirmed with the serum uric acid level in the (although there some cases where gout attacks people with normal uric acid level).

• there is not direct correlation between pseudogout with any of the elements in the blood test, the most accurate test whether a patient is having CPPD is through X-ray.

• This is because pseudogout is a type of calcifications known as chondocalcinosis and calcium compound deposit is visible on the X-ray films.

Diagnosis

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Treatment

• Treatments for pseudogout are same as the treatments for gout. This is because both cases have the same immune reactions that cause inflammation and pain regardless of what type of crystal that triggers it.

• Thus, colchicines and NSAIDs (ibuprofen) are applicable to pseudogout patients. The only exception is allopurinol which controls the uric acid level in the blood, it will be useless in the case of CPPD.

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Gout Pseudogout

PREDOMINANT SEX:

95% males, rare in females before menopause

Female:male ratio of approximately 1.5:1

PREDOMINANT AGE

30 to 50 yr 60 to 70 yr at onset

Etiology Excessive uric acid production, a decrease in the renal excretion of uric acid, or both.

• Unknown• Often associated with

various medical conditions, including hyperparathyroidism and amyloidosis

deposits monosodium urate calcium pyrophosphate dehydrate (CPPD)

Joint involvement

typically monarticular at forst presentation or oligoarticular

monoarticular

treatment important to relieve pain, prevent disease progression, and prevent tissue deposition of uric acid (eg, in the kidneys) that may produce kidney stones or urate nephropathy

identical to that of gout. Unlike gout, however, no specific therapeutic regimen exists to treat the underlying cause of pseudogout, but colchicine and hydroxychloroquine are effective for prophylaxis