gnipst bulletin 24.2.pdf
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GNIPST BULLETIN 2013
05th April 2013 Volume No.: 24 Issue No.: 02
ContentsMessage from GNIPS
Letter to the EditorNews Update
Disease Outbreak Ne
Health Awareness
Forth Coming Events
Drugs Update
Campus News
Students Section
Editors Note
Archive
Vision
TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD O
PHARMACEUTICAL AND BIOLOGICAL SCIENCE
EDITOR:DebabrataGhoshDastidarGURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE ANDTECHNOLOGY
GNIPST Photo Gallery
For your comments/contributionOR
For Back-Issues,
mailto:[email protected]
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MESSAGE FROM GNIPSTAll the members of GNIPST are proud to publish the 24th Volume
of GNIPST BULLETIN. This bulletin has successfully
completed its twenty months journey. We hope it haskept the
readersupdated of recent activities in pharmaceutical & biological
sciences and also introduced them with the different activities of
our esteemed institution. We are thankful to all of you for your
great cooperation & support and are looking forward to the samein
future.
LETTER TO THE EDITOR.
NEWS UPDATE
WORLD HEALTH DAY 2013: 07 April
To mark World Health Day on 7 April, WHO is calling for
intensified efforts to prevent and control hypertension, also
known as high blood pressure. Worldwide, high blood pressure is
estimated to affect more than one in three adults aged 25 and over,
or about one billion people. Hypertension is a major contributor to
heart disease and stroke which together make up the worlds
number one cause of premature death and disability.Read more
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http://www.who.int/campaigns/world-health-day/2013/en/index.htmlhttp://www.who.int/campaigns/world-health-day/2013/en/index.htmlhttp://www.who.int/campaigns/world-health-day/2013/en/index.htmlhttp://www.who.int/campaigns/world-health-day/2013/en/index.html -
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HIV Self-Testing: The Key to Controlling the
Global Epidemic(02 APRIL 2013)
A new international study has confirmed that self-testing for HIVis effective and could be the answer to controlling the global
epidemic. This systematic review shows HIV self-testing removes
much of the fear and stigma associated with being tested for the
disease. This study could pave the way for early detection and
treatment around the world, thereby reducing transmission. Readmore
Feeling Hungry May Protect the Brain Against
Alzheimer's Disease (02 APRIL 2013)
A study in mice with genetic mutations seen in human
Alzheimer's disease found that the feeling of hunger itself mayprotect against the disease.Read more
White Blood Cell Enzyme Contributes to
Inflammation and Obesity(02 APRIL 2013)
Researchers have discovered that an imbalance between the
enzyme neutrophil elastase and its inhibitor, 1-antitrypsin, causes
inflammation, obesity, insulin resistance, and fatty liver disease.
Read more
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Decreased Melatonin Secretion Associated With
Higher Risk of Developing Type 2 Diabetes
(02 APRIL 2013)
With previous evidence suggesting that melatonin may have a role
in glucose metabolism, researchers have found an independent
association between decreased secretion of melatonin and an
increased risk for the development of type 2 diabetes.Read moreHow Antibodies Neutralize Mosquito-Borne Virus
(02 APRIL 2013)
Researchers have learned the precise structure of the mosquito-
transmitted chikungunya virus pathogen while it is bound toantibodies, showing how the infection is likely neutralized. Readmore
Baldness Linked to Increased Risk of Coronary
Heart Disease(03 APRIL 2013)
Male pattern baldness is linked to an increased risk of coronary
heart disease, but only if it's on the top/crown of the head, rather
than at the front, a new analysis finds.Read more Potential Therapy for Human Prion Disease.
(03 APRIL 2013)
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Scientists have for the first time identified a pair of drugs already
approved for human use that show anti-prion activity and, for one
of them, great promise in treating rare and universally fatal
disorders, such as Creutzfeldt-Jakob disease, caused by misfoldedproteins called prions.Read more
Will Cell Therapy Become a 'Third Pillar' of
Medicine? (03 APRIL 2013)
Treating patients with cells may one day become as common as it
is now to treat the sick with drugs made from engineered proteins,
antibodies or smaller chemicals, according to UC San Francisco
researchers. They have outlined their vision of cell-based
therapeutics as a "third pillar of medicine.Read more Immune System: The Healing Element Is Also
the Enemy(03 APRIL 2013)
The same factor in our immune system that is instrumental in
enabling us to fight off severe and dangerous inflammatory
ailments is also a player in doing the opposite at a later stage,
causing the suppression of our immune response.Read moreVaccine Adjuvant Uses Host DNA to Boost
Pathogen Recognition(05 APRIL 2013)
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http://www.sciencedaily.com/releases/2013/04/130403154305.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29http://www.sciencedaily.com/releases/2013/04/130403154305.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29http://www.sciencedaily.com/releases/2013/04/130403141434.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29http://www.sciencedaily.com/releases/2013/04/130403141434.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29http://www.sciencedaily.com/releases/2013/04/130403072003.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29http://www.sciencedaily.com/releases/2013/04/130403072003.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29http://www.sciencedaily.com/releases/2013/04/130403072003.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29http://www.sciencedaily.com/releases/2013/04/130403141434.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29http://www.sciencedaily.com/releases/2013/04/130403154305.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine+%28ScienceDaily%3A+Health+%26+Medicine+News%29 -
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Aluminum salts, or alum, have been injected into billions of people
as an adjuvant to make vaccines more effective. No one knows,
however, how they boost the immune response. Researchers
continue unraveling the mystery of adjuvants with a report that
host DNA coats the alum adjuvant and induces two crucial cells to
interact twice as long during the initial stimulation of the adaptive
immune system.Read more.
HEALTH AWARENESS
CARDIOVASCULAR DISEASES
What are cardiovascular diseases?
Cardiovascular diseases (CVDs) are a group of
disorders of the heart and blood vessels andthey include:
coronary heart disease
disease of the blood vessels supplying the heart
muscle;
cerebrovascular disease - disease of the blood vessels
supplying the brain;
peripheral arterial disease disease of blood vessels
supplying the arms and legs;
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rheumatic heart disease damage to the heart muscle
and heart valves from rheumatic fever, caused by
streptococcal bacteria;
congenital heart disease - malformations of heart
structure existing at birth;
deep vein thrombosis and pulmonary embolism blood
clots in the leg veins, which can dislodge and move to the
heart and lungs.
Heart attacks and strokes are usually acute events and are
mainly caused by a blockage that prevents blood from flowing to
the heart or brain. The most common reason for this is a build-up
of fatty deposits on the inner walls of the blood vessels that
supply the heart or brain. Strokes can also be caused by bleeding
from a blood vessel in the brain or from blood clots.
What are the risk factors for cardiovascular disease?
The most important behavioural risk factors of heart disease and
stroke are unhealthy diet, physical inactivity, tobacco use andharmful use of alcohol. Behavioural risk factors are responsible
for about 80% of coronary heart disease and cerebrovascular
disease.
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The effects of unhealthy diet and physical inactivity may show
up in individuals as raised blood pressure, raised blood glucose,
raised blood lipids, and overweight and obesity. These
intermediate risks factors can be measured in primary care
facilities and indicate an increased risk of developing a heart
attack, stroke, heart failure and other complications.
Cessation of tobacco use, reduction of salt in the diet, consuming
fruits and vegetables, regular physical activity and avoidingharmful use of alcohol have been shown to reduce the risk of
cardiovascular disease. The cardiovascular risk can also be
reduced by preventing or treating hypertension, diabetes and
raised blood lipids.
Policies that create conducive environments for making healthy
choices affordable and available are essential for motivating
people to adopt and sustain healthy behavior.
There are also a number of underlying determinants of CVDs, or
"the causes of the causes". These are a reflection of the major
forces driving social, economic and cultural change
globalization, urbanization, and population ageing. Other
determinants of CVDs include poverty, stress and hereditary
factors.
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What are common symptoms of cardiovascular diseases?
Symptoms of heart attacks and strokes
Often, there are no symptoms of the underlying disease of the
blood vessels. A heart attack or stroke may be the first warning
of underlying disease. Symptoms of a heart attack include:
pain or discomfort in the centre of the chest;
pain or discomfort in the arms, the left shoulder, elbows,
jaw, or back.
In addition the person may experience difficulty in breathing or
shortness of breath; feeling sick or vomiting; feeling light-headed
or faint; breaking into a cold sweat; and becoming pale. Women
are more likely to have shortness of breath, nausea, vomiting, and
back or jaw pain.
The most common symptom of a stroke is sudden weakness of
the face, arm, or leg, most often on one side of the body. Other
symptoms include sudden onset of:
numbness of the face, arm, or leg, especially on one side ofthe body;
confusion, difficulty speaking or understanding speech;
difficulty seeing with one or both eyes;
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difficulty walking, dizziness, loss of balance or
coordination;
severe headache with no known cause; and fainting or
unconsciousness.
People experiencing these symptoms should seek medical care
immediately.
What is rheumatic heart disease?
Rheumatic heart disease is caused by damage to the heart valves
and heart muscle from the inflammation and scarring caused by
rheumatic fever. Rheumatic fever is caused by streptococcal
bacteria, which usually begins as a sore throat or tonsillitis in
children.
Rheumatic fever mostly affects children in developing countries,
especially where poverty is widespread. Globally, almost 2% of
deaths from cardiovascular diseases is related to rheumatic heart
disease, while 42% of deaths from cardiovascular diseases is
related to ischaemic heart disease, and 34% to cerebrovascular
disease.
Symptoms of rheumatic heart disease
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Symptoms of rheumatic heart disease include: shortness of
breath, fatigue, irregular heart beats, chest pain and
fainting.
Symptoms of rheumatic fever include: fever, pain and
swelling of the joints, nausea, stomach cramps and
vomiting.
Treatment
Early treatment of streptococcal sore throat can stop the
development of rheumatic fever. Regular long-term penicillin
treatment can prevent repeat attacks of rheumatic fever which
give rise to rheumatic heart disease and can stop disease
progression in people whose heart valves are already damaged by
the disease.
Why are cardiovascular diseases a development issue in low-
and middle-income countries?
Over 80% of the world's deaths from CVDs occur in low-
and middle-income countries.
People in low- and middle-income countries are more
exposed to risk factors such as tobacco, leading to CVDs
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and other noncommunicable diseases. At the same time
they often do not have the benefit of prevention
programmes compared to people in high-income
countries.
People in low- and middle-income countries who suffer
from CVDs and other noncommunicable diseases have
less access to effective and equitable health care services
which respond to their needs (including early detection
services).As a result, many people in low- and middle-income countries
die younger from CVDs and other noncommunicable diseases,
often in their most productive years.
The poorest people in low- and middle-income countries are
affected most. At the household level, sufficient evidence is
emerging to prove that CVDs and other noncommunicable
diseases contribute to poverty due to catastrophic health
spending and high out of pocket expenditure.
At macro-economic level, CVDs place a heavy burden on the
economies of low- and middle-income countries.
Noncommunicable disease including cardiovascular disease and
diabetes are estimated to reduce GDP by up to 6.77% in low- and
middle-income countries experiencing rapid economic growth,
as many people die prematurely.
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How can the burden of cardiovascular diseases be reduced?
Very cost effective interventions that are feasible to be
implemented even in low resource settings have been identified
by WHO for prevention and control of cardiovascular diseases.
Heart disease and stroke can be prevented through healthy diet,
regular physical activity and avoiding tobacco smoke.
Individuals can reduce their risk of CVDs by engaging in regularphysical activity, avoiding tobacco use and second-hand tobacco
smoke, choosing a diet rich in fruit and vegetables and avoiding
foods that are high in fat, sugar and salt, and maintaining a
healthy body weight and avoiding the harmful use of alcohol.
Comprehensive and integrated action is the means to prevent
and control CVDs.
Comprehensive action requires combining approaches
that seek to reduce the risks throughout the entire
population with strategies that target individuals at high
risk or with established disease.
Examples of population-wide interventions that can be
implemented to reduce CVDs include: comprehensive tobacco
control policies, taxation to reduce the intake of foods that are
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high in fat, sugar and salt, building walking and cycle paths to
increase physical activity, providing healthy school meals to
children.
Integrated approaches focus on the main common risk
factors for a range of chronic diseases such as CVD,
diabetes and cancer: unhealthy diet, physically inactivity
and tobacco use.
There are several intervention options available. Some of these
interventions can be implemented even by non-physician healthworkers in close- to- client facilities. They are very cost effective
and high impact interventions and have been prioritized by
WHO. For example:
People at high risk can be identified early in primary care,
using simple tools such as specific risk prediction charts.
If people are identified early, inexpensive treatment is
available to prevent many heart attacks and strokes.
Survivors of a heart attack or stroke are at high risk of
recurrences and at high risk of dying from them. The risk
of a recurrence or death can be substantially lowered
with a combination of drugs statins to lowercholesterol, drugs to lower blood pressure, and aspirin.
In addition surgical operations are sometimes required to
treat CVDs. They include coronary artery bypass, balloon
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angioplasty (where a small balloon-like device is
threaded through an artery to open the blockage), valve
repair and replacement, heart transplantation, and
artificial heart operations.
Medical devices are required to treat some CVDs. Such
devices include pacemakers, prosthetic valves, and
patches for closing holes in the heart.
There is a need for increased government investment inprevention and early detection through national programmes
aimed at prevention and control of noncommunicable
diseases including CVDs.
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DISEASE OUTBREAK NEWS
FORTHCOMING EVENTS
DRUGS UPDATES
FDA approves Invokana to treat type 2
diabetes. (29 MARCH 2013)The U.S. FDA approved Invokana (canagliflozin) tablets, used with
diet and exercise, to improve glycemic control in adults with type
2 diabetes.Read moreFDA approves new multiple sclerosis treatment:
Tecfidera(27 MARCH 2013)The U.S. FDA approved approved Tecfidera (dimethylfumarate) capsules to treat adults with relapsing forms ofm ultiple sclerosis (M S).Read more
CAMPUS NEWS
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http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345848.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345848.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345848.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345528.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345528.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345528.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345528.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345848.htm -
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STUDENTS SECTION
WHO CAN ANSWER FIRST???() Which analytical principle was invented by
Archer J Martin and Richard Synge?
() In 1996 which pharmaceutical company wascreated from the merging of two pharma
companies: Ciba Geigy and Sandoz
Laboratories?Answer of Previous Issue Question:
A) Ranitidine B) Confocal ImagingCongratulation Sreemanti Mazumder, B.Pharm final year,
for correct answer.
Send yourthoughts/ Quiz/Puzzles/games/write-ups or any other contributions for Students Section
& answers of this Section at [email protected]
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EDITORS NOTE
I am very happy to publish the 2nd issue of 24th Volume of GNIPST
BULLETIN. It is my great pleasure to introduce you to the newly
launched facebook account GNIPST bulletin. You are cordially
invited to add this account to your friend list. The current issues will
also be directly available on facebook.
I would like to convey my thanks to all the GNIPST members and
the readers for their valuable comments, encouragement& supports.
Special thanks to Dr. Prerona Saha for her advice; Mr. Soumya
Bhattacharya, for his contribution instudents section.
It would be my great pleasure to receive the contributions,
suggestions & feedback from your desk for further upliftment of this
deliberation GNIPST BULLETIN.
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ARCHIVE
The general body meeting of APTI, Bengal Branch has been
conducted at GNIPST on 15th
June, 2012. The programme startedwith a nice presentation by Dr. Pulok Kr. Mukherjee, School of
Natural Products, JU on the skill to write a good manuscript for
publication in impact journals. It was followed by nearly two hour
long discussion among more than thirty participants on different
aspects of pharmacy education. Five nonmember participants
applied for membership on that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years post graduate course (M.Pharm) in
P H A R M A C O L O G Y . The approved number of seat is 18.The number of seats in B.Pharm. has been increased from 60 to
120.
2nd World Congress on Ga-68 (Generators and Novel Radiopharmaceuticals),
Molecular Imaging (PET/CT), Targeted Radionuclide Therapy, and
Dosimetry (SWC-2013) : On the Way to Personalized Medicine
Dates 28 Feb 2013
02 Mar 2013Location: Chandigarh, India.Details.
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http://www.2ndworldcongress-ga-68.de/http://www.2ndworldcongress-ga-68.de/http://www.2ndworldcongress-ga-68.de/http://www.2ndworldcongress-ga-68.de/ -
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AICTE has sanctioned a release of grant under Research
Promotion Scheme (RPS) during the financial year 2012-
13to GNIPST as per the details below:
a. Beneficiary Institution: Guru Nanak Institution of
Pharmaceutical Science & Technology.
b. Principal Investigator: Dr. LopamudraDutta.
c. Grant-in-aid sanctioned:Rs. 16,25000/- only
d. Approved duration: 3 years
e. Title of the project: Screening and identification ofpotential medicinal plant of Purulia&Bankuradistricts of West
Bengal with respect to diseases such as diabetes, rheumatism,
Jaundice, hypertension and developing biotechnological tools for
enhancing bioactive molecules in these plant.
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