global markets and technologies for molecular, nanoscale and atomic imaging

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Global Markets and Technologies for Molecular, Nanoscale and

Atomic Imaging

Published on March 2013

Report Summary

REPORT SCOPE

INTRODUCTION

STUDY OBJECTIVES

BCC's goal in conducting this study is to provide an overview of the current and future characteristics of the global markets and

technologies for molecular, nanoscale and atomic imaging. The key objective is to present the future direction and comprehensive

analysis for the molecular, nanoscale and atomic imaging technologies markets, and their positions in the overall global imaging

market.

This report explores present and future strategies within the global markets and technologies for molecular, nanoscale and atomic

imaging, including the electron and ion microscope market, the imaging probes market, the scanning probe market and the optical

and thermal imaging market. The improvisation of the market, the setbacks and the needs of the market are discussed in this report.

The comparisons, usage and the advantages and disadvantages of different types of technologies related to molecular, nanoscale

and atomic imaging are also portrayed in this report.

A detailed analysis based on the global markets and technologies of molecular, nanoscale and atomic imaging's industry structure

has also been conducted. Revenues are broken down by type, application and region. Sales figures are estimated for the five-year

period from 2012 through 2017.

Applications for the different technologies associated with molecular, nanoscale and atomic imaging are also discussed separately in

the report, with emphasis of the usage of the molecular, nanoscale and atomic imaging in various commercial and industrial fields.

The report also covers significant patents and their allotments in each category.

REASONS FOR DOING THIS STUDY

Extensive research in the fields of molecular, nanoscale and atomic imaging has allowed for an overall growth in the technological

advancements in the markets. This has led to the availability and accessibility of high-resolution imaging modalities.

R&D spending, along with increasing competition, patent expiries and new technologies are directing this in a new direction. The

overall revenue for the market has seen a steady increase from 2010 to 2012 mainly due to new advancements, new product

launches and to meet the demands of new end-user industries. This study looks at almost all of the systems affected by these factors.

Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strengths and

weaknesses of each type/ technology in light of new technologies, growing competition and changing customer needs.

CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE

Global Markets and Technologies for Molecular, Nanoscale and Atomic Imaging (From Issuu) /21

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This study contributes to the areas of market growth in the overall area of imaging modalities, including molecular, nanoscale and

atomic imaging markets. It also contributes to specific areas of market growth within the imaging market including the electron and ion

microscope market, the imaging probes market, the scanning probe market and the optical and thermal imaging market.

Pharmaceutical biotechnical companies, research institutes and physicians will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study encompasses the global markets and technologies of the molecular, nanoscale and atomic imaging markets

in pharmaceutical and biotechnology markets. BCC analyzes each market and its applications, regulatory environment, technology

involved, market projections and market share. Technological issues include the latest trends and developments. The emerging

market for molecular, nanoscale and atomic imaging includes countries such as India, China, Japan, Korea, Taiwan, Africa, Australia

and New Zealand.

METHODOLOGY

BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data

were collected through interviews and correspondence with manufacturers and technical experts of molecular, nanoscale and atomic

imaging. Projections were based on estimates such as the current number of end users, potential end users, mergers and

acquisitions, and market trends.

INFORMATION SOURCES

Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of

molecular, nanoscale and atomic imaging. Data were gathered from various industry sources. BCC spoke with officials within the

industry and consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and

abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current

financial, trade and government sources.

ABOUT THE AUTHOR

The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project was

Shalini S. Dewan, who holds a master's degree in pharmaceutical chemistry and has over 14 years of industry experience. Among

the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl

acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India

and in the U.S. Some of her other reports with BCC are: Reagents for Chromatography; Spectroscopy: An Enduring Market;

Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging

Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in

Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global

Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver

Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets;

Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

The lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in life sciences. She has a number of research

publications in her credit, including her thesis, which was given an award of excellence.

REPORT HIGHLIGHTS

This report provides:









' An overview of the global market for molecular, nanoscale, and atomic imaging.

' Analyses of global market trends, with data from 2010 through 2012, and projections of compound annual growth rates (CAGRs)

through 2017.

' Descriptions of imaging equipment and technologies for examining materials, electronics, and biological samples.

' Coverage of technological issues, including novel molecular, nanometer, and atomic imaging capabilities.

' Examination of research activities and areas of interest related to imaging applications.

' Comprehensive company profiles of major players.

Table of Content

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY OBJECTIVES 2

REASONS FOR DOING THIS STUDY 2

CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE 3

SCOPE OF THE STUDY 3

METHODOLOGY 3

INFORMATION SOURCES 3

ABOUT THE AUTHOR 3

RELATED BCC RESEARCH REPORTS 4

BCC ONLINE SERVICES 4

DISCLAIMER 5

CHAPTER 2 EXECUTIVE SUMMARY 7

SUMMARY TABLE GLOBAL REVENUE OF MOLECULAR, ATOMIC AND

NANOSCALE IMAGING, THROUGH 2017 ($ MILLIONS) 8

SUMMARY FIGURE GLOBAL REVENUE OF MOLECULAR, ATOMIC AND

NANOSCALE IMAGING, 2010-2017 ($ MILLIONS) 8

CHAPTER 3 OVERVIEW 10

DEFINITIONS 10

HISTORY AND DEVELOPMENT OF IMAGING TECHNIQUES 11

TABLE 1 HISTORY AND DEVELOPMENT OF IMAGING TECHNIQUES 12

CLASSIFICATION OF IMAGING TECHNIQUES 13

OPTICAL AND THERMAL IMAGING 13

Bioluminescent and Fluorescent Microscopy 14

Fluorescent and Bioluminescence Proteins 14

Applications of Fluorescent Proteins 15

Applications of Bioluminescence Proteins 16

Infrared Thermal Imaging 16









Applications of Infrared Thermal Imaging 16

TABLE 2 ADVANTAGES AND DISADVANTAGES OF INFRARED THERMAL

IMAGING 17

ELECTRON AND ION MICROSCOPY 17

Transmission Electron Microscope (TEM) 18

Applications of Transmission Electron Microscope 18

TABLE 3 ADVANTAGES AND DISADVANTAGES OF TRANSMISSION ELECTRON

MICROSCOPES 19

Scanning Electron Microscope (SEM) 19

Applications of Scanning Electron Microscopes 19

TABLE 4 ADVANTAGES AND DISADVANTAGES OF SCANNING ELECTRON

MICROSCOPES 20

Field Ion Microscopy 20

Applications of Field Ion Microscopy 21

TABLE 5 ADVANTAGES AND DISADVANTAGES OF FIELD ION MICROSCOPY 21

SCANNING PROBE MICROSCOPY (SPM) 21

Scanning Tunneling Microscope (STM) 22

Applications of Scanning Tunneling Microscope 22

TABLE 6 ADVANTAGES AND DISADVANTAGES OF SCANNING TUNNELING

MICROSCOPES 23

Atomic Force Microscopy (AFM) 23

Modes of Operation 23

Applications of Atomic Force Microscopy 24

TABLE 7 ADVANTAGES AND DISADVANTAGES OF ATOMIC FORCE

MICROSCOPY 25

Magnetic Force Microscopy (MFM) 25

Applications of Magnetic Force Microscopy 25

TABLE 8 ADVANTAGES AND DISADVANTAGES OF MAGNETIC FORCE

MICROSCOPY 26

Near-Field Scanning Optical Microscopy (NSOM) 26

Applications of Near-Field Scanning Optical Microscopy 26

TABLE 9 ADVANTAGES AND DISADVANTAGES OF NEAR-FIELD SCANNING

OPTICAL MICROSCOPY 27

PROBES 27

MOLECULAR PROBES 28

NANOPARTICLES 28

QUANTUM DOTS 30

CHAPTER 4 REGULATORY ASPECTS 33

TABLE 10 MEMBER AGENCIES OF NATIONAL NANOTECHNOLOGY

INITIATIVE 33

NANOTECHNOLOGY PROGRAMS AT THE FDA 36

CENTER FOR BIOLOGICS EVALUATION AND RESEARCH (CBER)

PROGRAMS 36

Center for Drug Evaluation and Research (CDER) Nanotechnology

Programs 37

Center for Devices and Radiological Health (CDRH) Nanotechnology









Programs 37

Center for Food Safety and Applied Nutrition (CFSAN)

Nanotechnology Programs 37

Center for Veterinary Medicine (CVM) Nanotechnology Programs 38

National Center for Toxicological Research (NCTR) Nanotechnology

Programs 38

EPA AND NANOTECHNOLOGY 38

CHAPTER 5 NEW DEVELOPMENTS 41

NEW DEVELOPMENTS IN IMAGING SYSTEMS 41

TABLE 11 NEW DEVELOPMENTS IN OPTICAL AND THERMAL MICROSCOPY 42

TABLE 12 NEW DEVELOPMENTS IN ELECTRON AND ION MICROSCOPY 43

TABLE 13 NEW DEVELOPMENTS IN SCANNING PROBE MICROSCOPY 46

NEW DEVELOPMENTS IN THE FIELD OF PROBES 47

CHAPTER 6 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR,

NANOSCALE AND ATOMIC IMAGING 51

MARKET BY TYPE 51

MARKET OVERVIEW 52

MARKET REVENUE 55

TABLE 14 GLOBAL MARKET AND TECHNOLOGIES FOR MOLECULAR,

NANOSCALE AND ATOMIC IMAGING BY TYPE, THROUGH 2017 ($ MILLIONS) 55

FIGURE 1 GLOBAL MARKET AND TECHNOLOGIES FOR MOLECULAR,

NANOSCALE AND ATOMIC IMAGING BY TYPE, 2010-2017 ($ MILLIONS) 55

MARKET SHARE 56

TABLE 15 MARKET SHARES OF GLOBAL MARKETS AND TECHNOLOGIES FOR

MOLECULAR, NANOSCALE AND ATOMIC IMAGING BY TYPE, 2011 (%) 56

FIGURE 2 MARKET SHARES OF GLOBAL MARKETS AND TECHNOLOGIES FOR


MARKET BY REGION 57

MARKET OVERVIEW 58

MARKET REVENUE 60

TABLE 16 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR,

NANOSCALE AND ATOMIC IMAGING BY REGION, THROUGH 2017 ($

MILLIONS) 60

FIGURE 3 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR,

NANOSCALE AND ATOMIC IMAGING BY REGION, 2010-2017 ($ MILLIONS) 60

MARKET SHARE 61


NANOSCALE AND ATOMIC IMAGING BY REGION, 2011 (%) 61



MARKET FOR ELECTRON AND ION MICROSCOPY BY REGION 62

MARKET OVERVIEW 62

MARKET REVENUE 63

TABLE 18 GLOBAL MARKET FOR ELECTRON AND ION MICROSCOPY BY









REGION, THROUGH 2017 ($ MILLIONS) 64

FIGURE 5 GLOBAL MARKET FOR ELECTRON AND ION MICROSCOPY BY

REGION, 2010-2017 ($ MILLIONS) 64

MARKET SHARE 64

TABLE 19 MARKET SHARE OF ELECTRON AND ION MICROSCOPY BY REGION,

2011 (%) 65

FIGURE 6 MARKET SHARE OF ELECTRON AND ION MICROSCOPY BY REGION,

2011 (%) 65

MARKET FOR IMAGING PROBES BY REGION 65

MARKET OVERVIEW 66

MARKET REVENUE 66

TABLE 20 GLOBAL MARKET FOR IMAGING PROBES BY REGION, THROUGH

2017 ($ MILLIONS) 67

FIGURE 7 GLOBAL MARKET FOR IMAGING PROBES BY REGION, 2010-2017 ($

MILLIONS) 67

MARKET SHARE 67

TABLE 21 MARKET SHARE OF IMAGING PROBES, BY REGION, 2011 (%) 68

FIGURE 8 MARKET SHARE OF IMAGING PROBES, BY REGION, 2011 (%) 68

MARKET FOR SCANNING PROBE MICROSCOPE BY REGION 68

MARKET OVERVIEW 69

MARKET REVENUE 69

TABLE 22 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY


FIGURE 9 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY


MARKET SHARE 70

TABLE 23 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY REGION,

2011 (%) 71

FIGURE 10 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY REGION,

2011 (%) 71

MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION 71

MARKET OVERVIEW 72

MARKET REVENUE 72

TABLE 24 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY


FIGURE 11 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY


MARKET SHARE 73

TABLE 25 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION,

2011 (%) 73

FIGURE 12 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY

REGION, 2011 (%) 73

MARKET BY APPLICATIONS 74

MARKET OVERVIEW 74

MARKET REVENUE 76


NANOSCALE AND ATOMIC IMAGING BY APPLICATIONS, THROUGH 2017 ($

MILLIONS) 76










NANOSCALE AND ATOMIC IMAGING BY APPLICATIONS, 2010-2017 ($

MILLIONS) 76

MARKET SHARE 77

TABLE 27 MARKET SHARE OF GLOBAL MARKETS AND TECHNOLOGIES FOR

MOLECULAR, NANOSCALE AND ATOMIC IMAGING, BY APPLICATIONS, 2011

(%) 77

FIGURE 14 MARKET SHARE OF GLOBAL MARKETS AND TECHNOLOGIES FOR

MOLECULAR, NANOSCALE AND ATOMIC IMAGING BY APPLICATIONS, 2011

(%) 77

CHAPTER 7 MARKET ANALYSIS OF OPTICAL AND THERMAL MICROSCOPY 79

MARKET BY TYPE 79

MARKET OVERVIEW 79

MARKET REVENUE 81

TABLE 28 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY TYPE,

THROUGH 2017 ($ MILLIONS) 82

FIGURE 15 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY TYPE,

2010-2017 ($ MILLIONS) 82

MARKET SHARE 82

TABLE 29 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 83

FIGURE 16 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 83

MARKET BY REGION 83

MARKET OVERVIEW 83

MARKET REVENUE 84



FIGURE 17 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY


MARKET SHARE 85


2011 (%) 86

FIGURE 18 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY

REGION, 2011 (%) 86

MARKET FOR OPTICAL IMAGING BY REGION 86

MARKET OVERVIEW 86

MARKET REVENUE 87

TABLE 32 GLOBAL MARKET FOR OPTICAL IMAGING BY REGION, THROUGH


FIGURE 19 GLOBAL MARKET FOR OPTICAL IMAGING BY REGION, 2010-2017

($ MILLIONS) 88

MARKET SHARE 88

TABLE 33 MARKET SHARE OF OPTICAL IMAGING BY REGION, 2011 (%) 88

FIGURE 20 MARKET SHARE OF OPTICAL IMAGING BY REGION, 2011 (%) 88

MARKET FOR THERMAL IMAGING BY REGION 89

MARKET OVERVIEW 89

MARKET REVENUE 90









TABLE 34 GLOBAL MARKET FOR THERMAL IMAGING BY REGION, THROUGH


FIGURE 21 GLOBAL MARKET FOR THERMAL IMAGING BY REGION, 2010-2017

($ MILLIONS) 91

MARKET SHARE 91

TABLE 35 MARKET SHARE OF THERMAL IMAGING BY REGION, 2011 (%) 91

FIGURE 22 MARKET SHARE OF THERMAL IMAGING BY REGION, 2011 (%) 91


TABLE 36 GLOBAL REVENUE FOR OPTICAL AND THERMAL IMAGING BY

APPLICATION, THROUGH 2017 ($ MILLIONS) 92

FIGURE 23 GLOBAL REVENUE FOR OPTICAL AND THERMAL IMAGING BY

APPLICATION, 2010-2017 ($ MILLIONS) 93

OPTICAL IMAGING 93

Market Revenue 94

TABLE 37 GLOBAL REVENUE FOR OPTICAL IMAGING BY APPLICATION,


FIGURE 24 GLOBAL REVENUE FOR OPTICAL IMAGING BY APPLICATION,

2010-2017 ($ MILLIONS) 94

THERMAL IMAGING 95

Market Revenue 96

TABLE 38 GLOBAL REVENUE FOR THERMAL IMAGING BY APPLICATION,


FIGURE 25 GLOBAL REVENUE FOR THERMAL IMAGING BY APPLICATION,

2010-2017 ($ MILLIONS) 96

MARKET SHARE 97

TABLE 39 MARKET SHARES OF OPTICAL AND THERMAL IMAGING BY

APPLICATION, 2011 (%) 97

FIGURE 26 MARKET SHARES OF OPTICAL AND THERMAL IMAGING BY


INDUSTRY STRUCTURE 98

OPTICAL IMAGING (FLUORESCENCE AND BIOLUMINESCENCE

IMAGING) 98

Market Leaders 98

TABLE 40 LEADING MANUFACTURERS OF OPTICAL IMAGING 98

Market Shares 99

TABLE 41 GLOBAL MARKET SHARES OF FLUORESCENCE AND

BIOLUMINESCENCE MICROSCOPES, 2011 (%) 100

FIGURE 27 GLOBAL MARKET SHARES OF FLUORESCENCE AND


THERMAL IMAGING 101

Market Leaders 101

TABLE 42 LEADING MANUFACTURERS OF THERMAL IMAGING SYSTEMS 101

Market Shares 102

TABLE 43 GLOBAL MARKET SHARES OF THERMAL IMAGING CAMERAS, 2011

(%) 103

FIGURE 28 GLOBAL MARKET SHARES OF THERMAL IMAGING CAMERAS,

2011 (%) 103









CHAPTER 8 MARKET ANALYSIS OF ELECTRON AND ION IMAGING 105

MARKET BY TYPE 105

MARKET OVERVIEW 105

MARKET REVENUE 105

TABLE 44 GLOBAL MARKET FOR ELECTRON AND ION IMAGING BY TYPE,


FIGURE 29 GLOBAL MARKET FOR ELECTRON AND ION IMAGING BY TYPE,

2010-2017 ($ MILLIONS) 106

MARKET SHARE 106


FIGURE 30 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 107

MARKET BY REGION 107

MARKET OVERVIEW 108

MARKET REVENUE 108





MARKET SHARE 110


2011 (%) 110

FIGURE 32 MARKET SHARE OF ELECTRON AND ION MICROSCOPY BY

REGION, 2011 (%) 110

MARKET FOR ELECTRON MICROSCOPY BY REGION 110

MARKET OVERVIEW 111

MARKET REVENUE 112

TABLE 48 GLOBAL MARKET FOR ELECTRON MICROSCOPES BY REGION,


FIGURE 33 GLOBAL MARKET FOR ELECTRON MICROSCOPES BY REGION,

2010-2017 ($ MILLIONS) 112

MARKET SHARE 113

TABLE 49 MARKET SHARE OF ELECTRON MICROSCOPES BY REGION, 2011

(%) 113

FIGURE 34 MARKET SHARE OF ELECTRON MICROSCOPES BY REGION, 2011

(%) 113

MARKET FOR ION MICROSCOPY BY REGION 113

MARKET OVERVIEW 114

MARKET REVENUE 115

TABLE 50 GLOBAL MARKET FOR ION MICROSCOPY BY REGION, THROUGH

2017 ($ MILLIONS) 115

FIGURE 35 GLOBAL MARKET FOR ION MICROSCOPY BY REGION, 2010-2017

($ MILLIONS) 115

MARKET SHARE 116

TABLE 51 MARKET SHARE OF ION MICROSCOPY BY REGION, 2011 (%) 116

FIGURE 36 MARKET SHARE OF ION MICROSCOPY BY REGION, 2011 (%) 116


MARKET REVENUE 118









TABLE 52 GLOBAL REVENUE FOR ELECTRON AND ION MICROSCOPY USED

IN VARIOUS SECTORS, THROUGH 2017 ($ MILLIONS) 119

FIGURE 37 GLOBAL REVENUE FOR ELECTRON AND ION MICROSCOPY USED

IN VARIOUS SECTORS, 2010-2017 ($ MILLIONS) 119

MARKET SHARE 119

TABLE 53 ELECTRON AND ION MARKET SHARES BY APPLICATION, 2011 (%) 120

FIGURE 38 ELECTRON AND ION MARKET SHARES BY APPLICATION, 2011 (%) 120


MARKET LEADERS 120

TABLE 54 LEADING MANUFACTURERS OF ELECTRON AND ION

MICROSCOPES 121

MARKET SHARES OF ELECTRON MICROSCOPY 122

TABLE 55 GLOBAL MARKET SHARES OF ELECTRON MICROSCOPES, 2011 (%) 122

FIGURE 39 GLOBAL MARKET SHARES OF ELECTRON MICROSCOPES, 2011 (%) 122

MARKET SHARES OF ION MICROSCOPY 123

TABLE 56 GLOBAL MARKET SHARES OF ION MICROSCOPY, 2011 (%) 123

FIGURE 40 GLOBAL MARKET SHARES OF ION MICROSCOPY, 2011 (%) 123

CHAPTER 9 MARKET ANALYSIS OF SCANNING PROBE MICROSCOPY 126

MARKET BY TYPE 126

MARKET OVERVIEW 126

MARKET REVENUE 128

TABLE 57 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY TYPE,


FIGURE 41 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY TYPE,

2010-2017 ($ MILLIONS) 128

MARKET SHARE 129

TABLE 58 MARKET SHARE OF SCANNING PROBE MICROSCOPY, 2011 (%) 129

FIGURE 42 MARKET SHARE OF SCANNING PROBE MICROSCOPY, 2011 (%) 129


MARKET OVERVIEW 130

MARKET REVENUE 130

TABLE 59 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY


FIGURE 43 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY


MARKET SHARE 132


2011 (%) 132

FIGURE 44 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY REGION,

2011 (%) 132

MARKET FOR ATOMIC FORCE MICROSCOPY BY REGION 132

MARKET OVERVIEW 133

MARKET REVENUE 133

TABLE 61 GLOBAL MARKET FOR ATOMIC FORCE MICROSCOPES BY REGION,


FIGURE 45 GLOBAL MARKET FOR ATOMIC FORCE MICROSCOPES BY REGION,









2010-2017 ($ MILLIONS) 134

MARKET SHARE 134

TABLE 62 MARKET SHARE OF ATOMIC FORCE MICROSCOPES BY REGION,

2011 (%) 135

FIGURE 46 MARKET SHARE OF ATOMIC FORCE MICROSCOPES BY REGION,

2011 (%) 135

MARKET FOR OTHER SCANNING PROBE MICROSCOPES BY REGION 135

MARKET OVERVIEW 136

MARKET REVENUE 136

TABLE 63 GLOBAL MARKET FOR OTHER SCANNING PROBE MICROSCOPES

BY REGION, THROUGH 2017 ($ MILLIONS) 136

FIGURE 47 GLOBAL MARKET FOR OTHER SCANNING PROBE MICROSCOPES

BY REGION, 2010-2017 ($ MILLIONS) 137

MARKET SHARE 137

TABLE 64 MARKET SHARE OF OTHER SCANNING PROBE MICROSCOPES BY

REGION, 2011 (%) 138

FIGURE 48 MARKET SHARE OF OTHER SCANNING PROBE MICROSCOPES BY

REGION, 2011 (%) 138


TABLE 65 GLOBAL REVENUE FOR SCANNING PROBE MICROSCOPY BY

APPLICATIONS, THROUGH 2017 ($ MILLIONS) 139

FIGURE 49 GLOBAL REVENUE FOR SCANNING PROBE MICROSCOPY BY

APPLICATIONS, 2010-2017 ($ MILLIONS) 139

ATOMIC FORCE MICROSCOPY 140

Market Revenue 141

TABLE 66 GLOBAL REVENUE FOR ATOMIC FORCE MICROSCOPES BY


FIGURE 50 GLOBAL REVENUE FOR ATOMIC FORCE MICROSCOPES BY

APPLICATIONS, 2010-2017 ($ MILLIONS) 141

OTHER SCANNING PROBE MICROSCOPES 142

Market Revenue 142

TABLE 67 GLOBAL REVENUE FOR OTHER SCANNING PROBE MICROSCOPES

BY APPLICATIONS, THROUGH 2017 ($ MILLIONS) 143

FIGURE 51 GLOBAL REVENUE FOR OTHER SCANNING PROBE MICROSCOPES

BY APPLICATIONS, 2010-2017 ($ MILLIONS) 143

Market Share 144

TABLE 68 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY


FIGURE 52 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY



MARKET LEADERS 144

TABLE 69 LEADING MANUFACTURERS OF SCANNING PROBE MICROSCOPES 144

MARKET SHARES 146

Atomic Force Microscopes 146

TABLE 70 GLOBAL MARKET SHARES OF ATOMIC FORCE MICROSCOPES,

2011 (%) 147

FIGURE 53 GLOBAL MARKET SHARES OF ATOMIC FORCE MICROSCOPES,









2011 (%) 147

Other Scanning Probe Microscopes 147

TABLE 71 GLOBAL MARKET SHARES OF OTHER SCANNING PROBE

MICROSCOPES, 2011 (%) 148

FIGURE 54 GLOBAL MARKET SHARES OF OTHER SCANNING PROBE


CHAPTER 10 IMAGING PROBES 150

MARKET BY TYPE 150

MARKET OVERVIEW 150

MARKET REVENUE 151

TABLE 72 GLOBAL MARKET FOR IMAGING PROBES BY TYPE, THROUGH 2017

($ MILLIONS) 152

FIGURE 55 GLOBAL MARKET FOR IMAGING PROBES BY TYPE, 2010-2017 ($

MILLIONS) 152

MARKET SHARE 153

TABLE 73 MARKET SHARE OF IMAGING PROBES, 2011 (%) 153

FIGURE 56 MARKET SHARE OF IMAGING PROBES, 2011 (%) 153


MARKET OVERVIEW 154

MARKET REVENUE 154


2017 ($ MILLIONS) 155

FIGURE 57 GLOBAL MARKET FOR IMAGING PROBES BY REGION, 2010-2017

($ MILLIONS) 155

MARKET SHARE 155

TABLE 75 MARKET SHARE OF IMAGING PROBES BY REGION, 2011 (%) 156

FIGURE 58 MARKET SHARE OF IMAGING PROBES BY REGION, 2011 (%) 156

MARKET FOR FLUORESCENT AND BIOLUMINESCENT PROBES BY

REGION 156

MARKET OVERVIEW 157

MARKET REVENUE 157

TABLE 76 GLOBAL MARKET FOR FLUORESCENT AND BIOLUMINESCENT

PROBES BY REGION, THROUGH 2017 ($ MILLIONS) 158

FIGURE 59 GLOBAL MARKET FOR FLUORESCENT AND BIOLUMINESCENT

PROBES BY REGION, 2010-2017 ($ MILLIONS) 158

MARKET SHARE 158

TABLE 77 MARKET SHARE OF FLUORESCENT AND BIOLUMINESCENT

PROBES BY REGION, 2011 (%) 159

FIGURE 60 MARKET SHARE OF FLUORESCENT AND BIOLUMINESCENT

PROBES BY REGION, 2011 (%) 159

MARKET FOR NANOPARTICLES AND QUANTUM DOTS BY REGION 159

MARKET OVERVIEW 160

MARKET REVENUE 160

TABLE 78 GLOBAL MARKET FOR NANOPARTICLES AND QUANTUM DOTS BY


FIGURE 61 GLOBAL MARKET FOR NANOPARTICLES AND QUANTUM DOTS BY










MARKET SHARE 161

TABLE 79 MARKET SHARE OF NANOPARTICLES AND QUANTUM DOTS BY

REGION, 2011 (%) 162

FIGURE 62 MARKET SHARE OF NANOPARTICLES AND QUANTUM DOTS BY

REGION, 2011 (%) 162


TABLE 80 GLOBAL REVENUE FOR IMAGING PROBES USED IN VARIOUS

SECTORS, THROUGH 2017 ($ MILLIONS) 163

FIGURE 63 GLOBAL REVENUE FOR IMAGING PROBES USED IN VARIOUS

SECTORS, 2010-2017 ($ MILLIONS) 163

FLUORESCENT AND BIOLUMINESCENT PROBES 164

Market Revenue 164

TABLE 81 GLOBAL REVENUE FOR FLUORESCENT AND BIOLUMINESCENT

PROBES USED IN VARIOUS SECTORS, THROUGH 2017 ($ MILLIONS) 165

FIGURE 64 GLOBAL REVENUE FOR FLUORESCENT AND BIOLUMINESCENT

PROBES USED IN VARIOUS SECTORS, 2010-2017 ($ MILLIONS) 165

NANOPARTICLES AND QUANTUM DOTS BY APPLICATION 166

Market Revenue 166

TABLE 82 GLOBAL REVENUE FOR NANOPARTICLES AND QUANTUM DOTS

USED IN VARIOUS SECTORS, THROUGH 2017 ($ MILLIONS) 167

FIGURE 65 GLOBAL REVENUE FOR NANOPARTICLES AND QUANTUM DOTS

USED IN VARIOUS SECTORS, 2010-2017 ($ MILLIONS) 167

MARKET SHARE 168

TABLE 83 IMAGING PROBES MARKET SHARES BY APPLICATION, 2011 (%) 168

FIGURE 66 IMAGING PROBES MARKET SHARES BY APPLICATION, 2011 (%) 168


FLUORESCENT AND BIOLUMINESCENCE IMAGING PROBES 169

Market Leaders 169

TABLE 84 LEADING MANUFACTURERS OF FLUORESCENCE AND

BIOLUMINESCENCE IMAGING PROBES 169

Market Shares 171


BIOLUMINESCENCE IMAGING PROBES, 2011 (%) 172

FIGURE 67 GLOBAL MARKET SHARES OF FLUORESCENCE AND


NANOPARTICLES AND QUANTUM DOTS 173

Market Leaders 173

TABLE 86 LEADING MANUFACTURERS OF QUANTUM DOTS 173

Market Shares 175

TABLE 87 GLOBAL MARKET SHARES OF NANOPARTICLES AND QUANTUM

DOTS, 2011 (%) 175

FIGURE 68 GLOBAL MARKET SHARES OF NANOPARTICLES AND QUANTUM

DOTS, 2011 (%) 175

CHAPTER 11 PATENT ANALYSIS 177

PATENT ANALYSIS OF IMAGING SYSTEMS 178









PATENTS BY YEAR 178

TABLE 88 NUMBER OF PATENTS BY YEAR, 2008-2012 (NUMBER/%) 178

FIGURE 69 NUMBER OF PATENTS, BY YEAR, 2008-2012 178

FIGURE 70 NUMBER OF PATENTS, BY YEAR, 2008-2012 (%) 178

PATENTS BY TYPE 179

TABLE 89 NUMBER OF PATENTS BY TYPE, 2008-2012 179

FIGURE 71 NUMBER OF PATENTS BY TYPE, 2008-2012 (NUMBER) 179

PATENTS BY COUNTRY 180

TABLE 90 NUMBER OF PATENTS BY COUNTRY, 2008-2012 181

FIGURE 72 NUMBER OF PATENTS BY COUNTRY, 2008-2012 181

PATENTS BY COMPANY 182

TABLE 91 NUMBER OF PATENTS BY COMPANY, 2008-2012 182

PATENTS BY ASSIGNEE 183

TABLE 92 NUMBER OF PATENTS BY ASSIGNEE, 2008-2012 184

FIGURE 73 NUMBER OF PATENTS BY ASSIGNEE, 2008-2012 184

PATENT ANALYSIS OF IMAGING PROBES 184

PATENTS BY YEAR 184

TABLE 93 NUMBER OF PATENTS BY YEAR, 2008-2012 185

FIGURE 74 NUMBER OF PATENTS BY YEAR, 2008-2012 185

FIGURE 75 NUMBER OF PATENTS BY YEAR, 2008-2012 (%) 185

PATENTS BY TYPE 186


FIGURE 76 NUMBER OF PATENTS BY TYPE, 2008-2012 186

PATENTS BY COUNTRY 186


PATENTS BY COMPANY 187


PATENTS BY ASSIGNEE 188


CHAPTER 12 CURRENT SITUATION 190

TRENDS IN MOLECULAR, ATOMIC AND NANOSCALE IMAGING 190

CONSIDERABLE GROWTH IN ELECTRON AND SCANNING PROBE

MICROSCOPES 190

ASIA PACIFIC REGIONS: KEY REGIONS OF GROWTH 191

FACTORS AFFECTING THE MARKET 191

PRODUCT INNOVATIONS 191

DEVELOPMENT OF HYBRID SYSTEMS 191

MINIATURIZATION OF ELECTRONIC DEVICES 192

NEED OF QUALITY CONTROL IN ELECTRONICS 192

BABY-BOOMER GENERATION 192

INCREASING INCIDENCE OF LIFE-THREATENING DISEASES 192

IMPROVING ECONOMIC CONDITIONS OF EMERGING COUNTRIES 193

GOVERNMENT SUPPORT 193

CHAPTER 13 COMPANY PROFILES 195









AFFYMETRIX 195

AGILENT TECHNOLOGIES INC. 195

ANASPEC INC. 196

A.P.E. RESEARCH 197

APPLIED NANOTECH HOLDINGS INC. 197

AXIS COMMUNICATIONS AB 198

BECTON DICKINSON COMPANY 198

BIOSEARCH TECHNOLOGIES INC. 199

BRUKER CORPORATION 199

CARL ZEISS MICROSCOPY GMBH 200

CLONTECH LABORATORIES 201

DANAHAR CORPORATION 202

FEI COMPANY 203

FLIR SYSTEMS INC. 203

FLUKE CORPORATION 204

HAMAMATSU CORPORATION 205

HITACHI HIGH-TECHNOLOGIES 205

JEOL LTD. 206

LAMBERT INSTRUMENTS 207

LIFE TECHNOLOGIES 207

NANOCO GROUP PLC 208

NANOPHASE TECHNOLOGIES CORPORATION 208

NIKON CORPORATION 209

NT-MDT COMPANY 209

OLYMPUS CORPORATION 210

OXFORD INSTRUMENTS 210

PERKIN ELMER 211

PROMEGA 212

RHK TECHNOLOGY INC. 212

SIGMA-ALDRICH 212

THERMO FISHER SCIENTIFIC 213

WITEC FOCUS INNOVATIONS 214

XENICS INFRARED SOLUTIONS 214

CHAPTER 14 APPENDIX: ABBREVIATIONS 217

LIST OF TABLES

SUMMARY TABLE GLOBAL REVENUE OF MOLECULAR, ATOMIC AND

NANOSCALE IMAGING, THROUGH 2017 ($ MILLIONS) 8

TABLE 1 HISTORY AND DEVELOPMENT OF IMAGING TECHNIQUES 12

TABLE 2 ADVANTAGES AND DISADVANTAGES OF INFRARED THERMAL

IMAGING 17

TABLE 3 ADVANTAGES AND DISADVANTAGES OF TRANSMISSION ELECTRON

MICROSCOPES 19

TABLE 4 ADVANTAGES AND DISADVANTAGES OF SCANNING ELECTRON









MICROSCOPES 20

TABLE 5 ADVANTAGES AND DISADVANTAGES OF FIELD ION MICROSCOPY 21

TABLE 6 ADVANTAGES AND DISADVANTAGES OF SCANNING TUNNELING

MICROSCOPES 23

TABLE 7 ADVANTAGES AND DISADVANTAGES OF ATOMIC FORCE

MICROSCOPY 25

TABLE 8 ADVANTAGES AND DISADVANTAGES OF MAGNETIC FORCE

MICROSCOPY 26

TABLE 9 ADVANTAGES AND DISADVANTAGES OF NEAR-FIELD SCANNING

OPTICAL MICROSCOPY 27

TABLE 10 MEMBER AGENCIES OF NATIONAL NANOTECHNOLOGY INITIATIVE 33

TABLE 11 NEW DEVELOPMENTS IN OPTICAL AND THERMAL MICROSCOPY 42

TABLE 12 NEW DEVELOPMENTS IN ELECTRON AND ION MICROSCOPY 43

TABLE 13 NEW DEVELOPMENTS IN SCANNING PROBE MICROSCOPY 46

TABLE 14 GLOBAL MARKET AND TECHNOLOGIES FOR MOLECULAR,

NANOSCALE AND ATOMIC IMAGING BY TYPE, THROUGH 2017 ($ MILLIONS) 55

TABLE 15 MARKET SHARES OF GLOBAL MARKETS AND TECHNOLOGIES FOR



NANOSCALE AND ATOMIC IMAGING BY REGION, THROUGH 2017 ($ MILLIONS) 60






2011 (%) 65



TABLE 21 MARKET SHARE OF IMAGING PROBES, BY REGION, 2011 (%) 68

TABLE 22 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY REGION,



2011 (%) 71




2011 (%) 73


NANOSCALE AND ATOMIC IMAGING BY APPLICATIONS, THROUGH 2017 ($

MILLIONS) 76

TABLE 27 MARKET SHARE OF GLOBAL MARKETS AND TECHNOLOGIES FOR

MOLECULAR, NANOSCALE AND ATOMIC IMAGING, BY APPLICATIONS, 2011

(%) 77

TABLE 28 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY TYPE,














2011 (%) 86

TABLE 32 GLOBAL MARKET FOR OPTICAL IMAGING BY REGION, THROUGH


TABLE 33 MARKET SHARE OF OPTICAL IMAGING BY REGION, 2011 (%) 88

TABLE 34 GLOBAL MARKET FOR THERMAL IMAGING BY REGION, THROUGH


TABLE 35 MARKET SHARE OF THERMAL IMAGING BY REGION, 2011 (%) 91

TABLE 36 GLOBAL REVENUE FOR OPTICAL AND THERMAL IMAGING BY

APPLICATION, THROUGH 2017 ($ MILLIONS) 92

TABLE 37 GLOBAL REVENUE FOR OPTICAL IMAGING BY APPLICATION,


TABLE 38 GLOBAL REVENUE FOR THERMAL IMAGING BY APPLICATION,


TABLE 39 MARKET SHARES OF OPTICAL AND THERMAL IMAGING BY


TABLE 40 LEADING MANUFACTURERS OF OPTICAL IMAGING 98



TABLE 42 LEADING MANUFACTURERS OF THERMAL IMAGING SYSTEMS 101

TABLE 43 GLOBAL MARKET SHARES OF THERMAL IMAGING CAMERAS, 2011

(%) 103

TABLE 44 GLOBAL MARKET FOR ELECTRON AND ION IMAGING BY TYPE,






2011 (%) 110

TABLE 48 GLOBAL MARKET FOR ELECTRON MICROSCOPES BY REGION,


TABLE 49 MARKET SHARE OF ELECTRON MICROSCOPES BY REGION, 2011 (%) 113

TABLE 50 GLOBAL MARKET FOR ION MICROSCOPY BY REGION, THROUGH

2017 ($ MILLIONS) 115

TABLE 51 MARKET SHARE OF ION MICROSCOPY BY REGION, 2011 (%) 116

TABLE 52 GLOBAL REVENUE FOR ELECTRON AND ION MICROSCOPY USED IN

VARIOUS SECTORS, THROUGH 2017 ($ MILLIONS) 119

TABLE 53 ELECTRON AND ION MARKET SHARES BY APPLICATION, 2011 (%) 120

TABLE 54 LEADING MANUFACTURERS OF ELECTRON AND ION

MICROSCOPES 121

TABLE 55 GLOBAL MARKET SHARES OF ELECTRON MICROSCOPES, 2011 (%) 122

TABLE 56 GLOBAL MARKET SHARES OF ION MICROSCOPY, 2011 (%) 123

TABLE 57 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY TYPE,


TABLE 58 MARKET SHARE OF SCANNING PROBE MICROSCOPY, 2011 (%) 129

TABLE 59 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY REGION,











2011 (%) 132

TABLE 61 GLOBAL MARKET FOR ATOMIC FORCE MICROSCOPES BY REGION,


TABLE 62 MARKET SHARE OF ATOMIC FORCE MICROSCOPES BY REGION,

2011 (%) 135

TABLE 63 GLOBAL MARKET FOR OTHER SCANNING PROBE MICROSCOPES BY


TABLE 64 MARKET SHARE OF OTHER SCANNING PROBE MICROSCOPES BY

REGION, 2011 (%) 138

TABLE 65 GLOBAL REVENUE FOR SCANNING PROBE MICROSCOPY BY


TABLE 66 GLOBAL REVENUE FOR ATOMIC FORCE MICROSCOPES BY


TABLE 67 GLOBAL REVENUE FOR OTHER SCANNING PROBE MICROSCOPES

BY APPLICATIONS, THROUGH 2017 ($ MILLIONS) 143

TABLE 68 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY


TABLE 69 LEADING MANUFACTURERS OF SCANNING PROBE MICROSCOPES 144

TABLE 70 GLOBAL MARKET SHARES OF ATOMIC FORCE MICROSCOPES, 2011

(%) 147

TABLE 71 GLOBAL MARKET SHARES OF OTHER SCANNING PROBE


TABLE 72 GLOBAL MARKET FOR IMAGING PROBES BY TYPE, THROUGH 2017

($ MILLIONS) 152

TABLE 73 MARKET SHARE OF IMAGING PROBES, 2011 (%) 153


2017 ($ MILLIONS) 155

TABLE 75 MARKET SHARE OF IMAGING PROBES BY REGION, 2011 (%) 156

TABLE 76 GLOBAL MARKET FOR FLUORESCENT AND BIOLUMINESCENT

PROBES BY REGION, THROUGH 2017 ($ MILLIONS) 158

TABLE 77 MARKET SHARE OF FLUORESCENT AND BIOLUMINESCENT PROBES

BY REGION, 2011 (%) 159

TABLE 78 GLOBAL MARKET FOR NANOPARTICLES AND QUANTUM DOTS BY


TABLE 79 MARKET SHARE OF NANOPARTICLES AND QUANTUM DOTS BY

REGION, 2011 (%) 162

TABLE 80 GLOBAL REVENUE FOR IMAGING PROBES USED IN VARIOUS

SECTORS, THROUGH 2017 ($ MILLIONS) 163

TABLE 81 GLOBAL REVENUE FOR FLUORESCENT AND BIOLUMINESCENT

PROBES USED IN VARIOUS SECTORS, THROUGH 2017 ($ MILLIONS) 165

TABLE 82 GLOBAL REVENUE FOR NANOPARTICLES AND QUANTUM DOTS

USED IN VARIOUS SECTORS, THROUGH 2017 ($ MILLIONS) 167

TABLE 83 IMAGING PROBES MARKET SHARES BY APPLICATION, 2011 (%) 168

TABLE 84 LEADING MANUFACTURERS OF FLUORESCENCE AND

BIOLUMINESCENCE IMAGING PROBES 169



TABLE 86 LEADING MANUFACTURERS OF QUANTUM DOTS 173









TABLE 87 GLOBAL MARKET SHARES OF NANOPARTICLES AND QUANTUM

DOTS, 2011 (%) 175

TABLE 88 NUMBER OF PATENTS BY YEAR, 2008-2012 (NUMBER/%) 178





TABLE 93 NUMBER OF PATENTS BY YEAR, 2008-2012 185





LIST OF FIGURES

SUMMARY FIGURE GLOBAL REVENUE OF MOLECULAR, ATOMIC AND

NANOSCALE IMAGING, 2010-2017 ($ MILLIONS) 8

FIGURE 1 GLOBAL MARKET AND TECHNOLOGIES FOR MOLECULAR,

NANOSCALE AND ATOMIC IMAGING BY TYPE, 2010-2017 ($ MILLIONS) 55

FIGURE 2 MARKET SHARES OF GLOBAL MARKETS AND TECHNOLOGIES FOR



NANOSCALE AND ATOMIC IMAGING BY REGION, 2010-2017 ($ MILLIONS) 60





FIGURE 6 MARKET SHARE OF ELECTRON AND ION MICROSCOPY BY REGION,

2011 (%) 65

FIGURE 7 GLOBAL MARKET FOR IMAGING PROBES BY REGION, 2010-2017 ($

MILLIONS) 67

FIGURE 8 MARKET SHARE OF IMAGING PROBES, BY








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