global initiative on gene- environment interactions in...
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Global initiative on gene-environment interactions indiabetes and obesity in specificpopulations
Countries involved
In 2011, under the research topic HEALTH2.4.3-4 on “Genetic and environmental factorsfor diabetes and obesity”, the EuropeanCommission funded four projects on specificpopulations with a total EU funding of 12 MEuros.
Funding schemeSpecific International CooperationAction (SICA) Collaborative projects
Contact coordinators
EU officersNathalie VercruysseStaffan Fraysse
John CHAMBERS Imperial College London E-mail : [email protected]
Epi-Migrant
GIFTSGraham A HITMAN Barts and The London School ofMedicine and DentistryQueen Mary University of London E-mail : [email protected]
Florin GRIGORESCU (INSERM)IURC (UMR-204),University of Montpellier 1 E-mail : [email protected]
Karien STRONKSAcademisch Medisch Centrumbij de Universiteit van AmsterdamE-mail : [email protected]
MEDIGENE
RODAM
Epi-Migrant
UK, India, Italy, Finland, Australia,Mauritius, Singapore, Sri Lanka, Japan
GIFTS
UK, Norway, Germany, Finland, Spain,India, Bangladesh, Pakistan
MEDIGENE
France, Spain, Italy, Greece, Romania,Albania, Turkey, Algeria, Morocco,Tunisia, Finland, Hungary, Russia
RODAM
The Netherlands, Ghana, Germany, UK,Uganda
European Union's research and innovationframework programme FP7
Imperial College of Science, Technology andMedicine, London, United Kingdom
Identification of epigenetic makers underlyingincreased risk of Type 2 diabetes in SouthAsians (Epi-Migrant)
Barts and The London, Queen Mary Universityof London, United Kingdom
Genomic and lifestyle predictors of fœtaloutcomes relevant to diabetes and obesity andtheir relevance to prevention strategies inSouth Asian people (GIFTS)
University of Montpellier-1, France
Genetic and environmental factors of insulinresistance syndrome and its long-termcomplications in immigrant Mediterraneanpopulations (MEDIGENE)
Academisch Medisch Centrum bij deUniversiteit van Amsterdam, The Netherlands
Type 2 diabetes and obesity among Sub-Saharan African native and migrantpopulations: dissection of environment andendogenous predisposition (RODAM)
Key factors explaining global, continuousincrease of prevalence of obesity and type 2diabetes (T2D) remain largely unknown.Immigration from native countries to Europeis accompanied by severe changes inlifestyle, which may be found in collision withspecific genetic susceptibilities for complexdisorders.
Context
Main objectives of four projects
Epi-Migrant
GIFTS
The project proposes to identify novelepigenetic markers underlying increased riskof T2D in South Asians including non-migrant(living in India) or immigrated in UK. Theauthors expect to develop a predictive panelof lifestyle, genetic, environment andepigenetic markers that can be used toexamine risk in population concomitant withthe survey of T2D prevalence in differentregions worldwide.
Combining prevention strategies, state-of-the-art genomics, social science and public health,a group of investigators in South Asia andEurope will focus on early life predictors ofmetabolic syndrome. This multi-disciplinarycollaborative approach will inform publichealth policy, provide guidelines and designlarge-scale pragmatic interventions to preventcomplex diseases.
Main expected outcomes
RODAM
MEDIGENE
The project proposes to identify geneticmarkers of insulin resistance in Mediterraneanpopulations based on genome wideassociation, locus refining and densehaplotype mapping. Clinicians, geneticists andanthropologists will collaborate in defininghistorical populations based on mitochondrial(mt)DNA and Y chromosome markers whilepartnership with archeologists will revealgenetic allelic variants on ancient (a)DNA ofantique Roman populations.
With the aim to study the complex interplaybetween environment (e.g. lifestyle),healthcare, biochemical and (epi)genetics inT2D and obesity, the investigators addressthese fundamental health issues among one ofthe largest Sub-Saharan immigrant population- the Ghanaians. Subjects will be recruited bya multi-centre study in rural and urban Ghana,Germany, Netherlands, and UK.
The four projects will guide interventionprograms to improve diagnosis and treatmentamong immigrants. Their cooperation willcontribute the the understanding of the globalimpact of obesity and diabetes beyond thespecific population studied.
Funded projects