global emerging fungal infection registry - ecmm.eu · referat 96 - arbeitsmedizin, ... i.e....

Global Emerging Fungal Infection Registry

Initiated in 2003

Report March 2013

Working group of the

Under the auspices of

Supported by unrestricted grants from Astellas Pharma, Gilead Sciences, Merck and Pfizer

Report March 2013 of 32

Table of Contents

Study Co-ordinators ......................................................................... 3

Introduction .................................................................................... 6

Current Results ............................................................................... 10

Achievements and Goals .................................................................. 17

Presentations 2010-2012 ............................................................... 17

Publications ................................................................................. 18

Awards ........................................................................................ 18

Recent Accomplishments ............................................................... 18

Goals for 2013 ............................................................................. 19

Contact Information ......................................................................... 20

Participating Institutions................................................................... 21


Study Co-ordinators

Clinical ID Microbiology Molecular Biology Pharmacology Pathology

Austria

Elisabeth Presterl, MD Allgemeines Krankenhaus -Universitätskliniken Wien Währinger Gürtel 18-20 1090 Wien T +43-1-40400-4440 F +43-1-4400-4418 elisabeth.presterl@meduni wien.ac.at

Cornelia Lass-Flörl, MD Institute of Hygiene, Microbiology and Social Medicine Universität Innsbruck Fritz-Pregl-Str. 3 6020 Innsbruck T +43-512-9003-70725 F +43-512-9003-73700 [email protected]

Walter Buzina, MD Institut für Hygiene Medizinische Universität Universitätsplatz 4 8010 Graz T +43-316-380-7719 F +43-316-380-9648 [email protected]

Ulrich Strasser. MD Institut für Pathologie Medizinische Universität Innsbruck Müllerstr. 44 A-6020 Innsbruck T +43-512-9003-71304 F +43-512-582-088 [email protected]

Brazil

Marcio Nucci, MD Hospital Universitário Universidade Federal do Rio de Janeiro Av. Brigadeiro Trompovsky S/N 21941-590 Rio de Janeiro T +55-21-2562-2463 F +55-21-2562-2460 [email protected]

Czech Republic

Zdeněk Ráčil, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20 62500 Brno T +420-53223-2830/3642 F +420-53223-3603 [email protected]

Iva Kocmanova, MD Dept. of Microbiology University Hospital Brno, Jihlavska 20 62500 Brno T +420 53223 2974 [email protected]

Martina Lengerova, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20 62500 Brno T +420 53223 3642 [email protected]

Mojmir Moulis, MD Dept. of Pathology University Hospital Brno Jihlavska 20 62500 Brno T +420 53223 1111 [email protected]

Ludmila Malaskova, MD Dept. of Biochemistery University Hospital Brno Jihlavska 20 62500 Brno T. +420 53223 3073 [email protected]

mailto:[email protected]













Germany

Oliver A. Cornely, MD, FIDSA, FACP Klinikum der Universität Klinik I für Innere Medizin 50924 Köln T +49-221-478-6494 F +49-221-478-3611 [email protected]

Guido Fischer, MS, PhD Landesgesundheitsamt Baden-Württemberg Referat 96 - Arbeitsmedizin, umweltbezogener Gesundheitsschutz Nordbahnhofstraße 135 70191 Stuttgart T +49-711-904-39620 F +49-711-904-37105 [email protected]

Ralf Bialek, MD MVZ Labor Dr. Krause Steenbeker Weg 25 24106 Kiel T +49-431-388-252 [email protected]

Fedja Farowski, Biochemist Klinikum der Universität Institut für Pharmakologie 50924 Köln T +49-221-478-87275 F +49 221 478 3611 [email protected]

Axel Hamprecht, MD Klinikum der Universität Institut f. Mikrobiologie, Immunologie u. Hygiene Goldenfelsstr. 19-2 D-50935 Köln T +49-221-478 32023 F +49-(0)221-478-32134 [email protected]

India

Anupma Jyoti Kindo, MD Dept. of Microbiology Sri Ramachandra Medical College/Research Institute No.1, Ramachandra Nagar Porur, Chennai, 600 116 T +91-944-523-9196 F +91 44 2476 5608 [email protected]








Israel

Morad Wattad, MD Rabin Medical Center Infectious Diseases Unit 39 Jabotinski St. 49100 Petah Tikva T +972-3-937-7377 F +972-3-937-6365 [email protected]

Italy

Livio Pagano, MD Dipartimento di Ematologia Universita Cattolica del Sacro Cuore (Roma) Largo Francesco Vito 1 00168 Roma T +39-6-355-03953 F +39-630-51343 [email protected]

Maurizio Sanguinetti, MD Istituto di Microbiologia (Roma) Università Cattolica del Sacro Cuore Largo Francesco Vito 1 00168 Roma T +39-06-3015-4964 F +39-06-3051-152 [email protected]

Annamaria Tortorano, MD Dip. Sanità Pubblica-Microbiologia-Virologia Milano Università di Milano Via Pascal, 36/38 20133 Milano T +39-2-503-15145 F +39-2-503-15146 [email protected]

Andrea Novelli, MD Dipartimento di Farmacologia Università degli Studi di Firenze Viale Pieraccini, 6 50139 Firenze T +39-055-4271-286 F +39-055-4271-280 [email protected]

Gianluigi Vago, MD Department of Clinical Sciences Luigi Sacco Hospital University of Milan Via Pascal, 36/38 20133 Milano T +39 0285994869 F +39 0285994800 [email protected]

Turkey

Sevtap Arikan-Akdagli, MD Mycology Laboratory (Ankara) Hacettepe University 06100 Ankara F +90 (312) 3115250 [email protected]









Introduction

The incidence of invasive fungal infections (IFI) is increasing in all parts of the world. The

etiology for this ongoing epidemiological development is not completely understood.

However, major contributing factors are the increasing number of transplantation procedures

undertaken around the world (estimated at 500,000 per year), a widening of the indications

for intensive chemotherapy, and the growing number of other clinical conditions requiring

immunosuppressive treatment.

Therapeutic standards have been developed for the most frequent IFI, i.e. candidiasis,

aspergillosis and cryptococcosis. However, the so called “emerging fungi” are also a reason

for the increased number of IFIs. Thus, clinicians are now facing infections due to a variety of

different fungi without any reliable treatment recommendations and therapeutic decision

making is not evidence based. Prevalence of “emerging fungi” is virtually unknown and there

is an additional knowledge gap in pathogen biology, since isolates have not been collected

systematically.

In order to overcome the lack of knowledge on epidemiology, clinical course, biology and

pathomechanisms, and finally to develop an evidence based diagnostic-therapeutic integrated

approach of IFI caused by “emerging fungi”, Fungiscope™ - A Global Emerging Fungal

Infection Registry has been created.

Fungiscope™ uses a web-based electronic case form accessible via www.fungiscope.net.

For inclusion into the registry patients require cultural, histopathological, serological or

molecular evidence of IFI and the associated clinical symptoms and signs. The clinical data on

underlying disorder and IFI will be collected and stored in an internet-based database.

Additionally, the pathogen strains and samples of infected tissue are collected, examined and

stored in a bio-bank – the Fungithek. The clinical and biological data are subsequently

evaluated and analysed. Figure 1a and b present the data / sample flow and overall project

structure. The clinical database and the bio-bank are connected and accessable to the public

via a web-based search engine - FungiQuest (figure 2).

In the following report we introduce the most current results and achievements. We also

discuss future goals and ongoing developments of the project.


Figure 1a: Project structure


Figure 1b: Material flow


Figure 2: FungiQuest database search engine


Current Results

Until now, 328 cases have been documented and considered valid. The most frequently

registered pathogens were Mucorales (previously termed Zygomycetes) (n=137; 41.8%),

Fusarium spp. (n=54; 16.5%), yeasts (n=48; 14.6%), and Dematiaceae (n=34; 10.4%)

followed by Penicillium spp. / Paecilomyces spp. (n=15; 4.6%) and Scedosporium spp.

(n=14; 4.3%) (figure 3). The majority of patients were Caucasian followed by Asian and

North/South American Indian origins (figure 4). The contribution of cases by country is

shown in figure 5.

Sites of infection differ among pathogens, see figure 6. In patients with invasive

mucormycosis, the lungs were the most commonly involved organs with an incidence of

67.9%. Other involved sites were the paranasal sinuses (23.4%), deep soft tissues

(16.8%) and the central nervous system (14.6%). Fusarium spp. infections most

frequently presented as blood stream infections (51.9%) or skin infections (48.1%). Other

commonly affected sites were lungs (35.2%) and deep soft tissues (20.4%). Infections

with Dematiaceae mostly involved the eyes, paranasal sinuses, deep soft tissues, and skin

(range from 11.8% - 32.4%). By contrast, yeasts were most often diagnosed from blood

cultures (66.7%) followed by pulmonary infections (27.1%).

The evaluation of risk factors for the development of IFI revealed differences between

individual pathogens shown in figure 7. The most common risk factors for developing an

infection with Mucorales and Fusarium spp. were chemotherapy (55.5% and 55.6%

respectively) or haematopoetic stem cell transplantation (HSCT) (approximately 30%)

followed by ICU stay and diabetes mellitus, with rates of 13.0– 26.3%.

Chemotherapy was also the most common risk factors in patients presenting with yeast

infections (47.9%). In addition, 33.3% of patients were treated in intensive care units.

Further risk factors were diabetes mellitus (14.6%) and solid organ transplantation,

chronic pulmonary disease, and haematopoetic stem cell transplantation (12.5%

respectively).

By contrast, patients with a Dematiaceae infection presented most frequently with

diabetes mellitus (47.1%) and/or chronic renal disease (17.6%).

All-cause-mortality, mortality due to fungal infection and response to treatment differed

among individual pathogens and are shown in figure 8. The highest all-cause-mortality

was observed in patients with mucormycosis (59.1%), followed by patients with yeast

(52.1%) and Fusarium spp. infections (48.1%). When looking at the mortality due to the

fungal infection it was highest in infections caused by Mucorales (44.5%) followed by

yeast (37.5%) and Fusarium spp (37.0%). By contrast, the lowest all-cause-mortality was

revealed in patients with Dematiaceae, equaling only 5.9%. None of these deaths was due

to the fungal infection. The highest rates of complete and partial remissions were

observed in patients with IFI caused by Dematiaceae and Penicillium/Paecilomyces spp

(73.5 and 80% respectively). Patients with a Mucorales infection displayed the lowest rate

of response to treatment (42.3%).

In conclusion, the clinical relevance of invasive fungal infections by emerging fungi is

increasing. In a short time, actual cases from several countries world-wide could be

documented and showed a broad spectrum of pathogens. Further investigators and

coordinators are encouraged to contribute to the success of Fungiscope™.


Figure 3: Distribution of 328 pathogens by major groups

137

54

48

34

15

14

26

Mucorales (previously Zygomycetes)

Fusarium

Yeast

Dematiaceae

Penicillium/Paecilomyces

Scedosporium

Other


Figure 4: Ethnicities

220

79

135 1 1

9

0

50

100

150

200

250


Figure 5: Case contributions by country


Figure 6: Risk factors for major groups

13%

19%

30%

56%

0% 10% 20% 30% 40% 50% 60%

Diabetes mellitus

ICU stay

HSCT

Chemotherapy

Fusarium spp (n=54)

18%

26%

29%

56%

0% 10% 20% 30% 40% 50% 60%

Diabetes mellitus

ICU stay

HSCT

Chemotherapy

Mucorales (previously Zygomycetes) (n=137)

10%

10%

13%

13%

13%

15%

33%

48%

0% 10% 20% 30% 40% 50% 60%

Major surgery

Chronic renal disease

HSCT

Solid organ transplant

Chronic pulmonary disease

Diabetes mellitus

ICU stay

Chemotherapy

Yeasts (n=48)

18%

47%

0% 10% 20% 30% 40% 50%

Chronic renal disease

Diabetes mellitus

Dematiaceae (n=34)


Figure 7: Sites of infection for major groups

Figure 7: Sites of infection for major groups

13%

13%

20%

35%

48%

52%

0% 10% 20% 30% 40% 50% 60%

Eyes

Paranasal sinus

Soft tissue

Lungs

Skin

Blood

Fusarium spp (n=54)

10%

12%

13%

15%

17%

23%

68%

0% 20% 40% 60% 80%

Skin

GI-Tract

Bones

Central nervous system

Soft tissue

Paranasal sinus

Lungs

Mucorales (previously Zygomycetes) (n=137)

12%

24%

27%

32%

0% 5% 10% 15% 20% 25% 30% 35%

Skin

Soft tissue

Paranasal Sinus

Eyes

Dematiaceae (n=34)

10%

13%

13%

15%

27%

67%

0% 20% 40% 60% 80%

Soft tissue

Kidney

Central nervous system

Liver

Lungs

Blood

Yeasts (n=48)


Figure 8: Outcomes for major group

59%

45%42%

48%

37%

52%52%

38%

52%

6%

0%

74%

0%

10%

20%

30%

40%

50%

60%

70%

80%

Mortality Mortality due to IFI Favourable outcome

Mucorles Fusarium spp. Yeasts Dematiacenae


Achievements and Goals

Presentations 2010 - 2012

October 19-23, 2012 Annual Congress of the German Society for Hematology and

Oncology (DGHO), Stuttgart, Germany

September 9-12, 2012 52nd Interscience Conference on Antimicrobial Agents and

Chemotherapy (ICAAC), San Francisco, CA, USA

June 23-26, 2012 18th Congress of the International Society for Human and

Animal Mycology, Berlin, Germany

April 25-28, 2012 11th Congress of Infectious Diseases and Tropical Medicine,

Cologne, Germany

March 31-April 3, 2012 22nd European Congress of Clinical Microbiology and

Infectious Diseases (ECCMID), London, UK

January 24-25, 2012 3rd WATL-Congress, Berlin, Germany

October 2-5, 2011 5th Trends in Medical Mycology (TIMM), Valencia, Spain

September 30-Oct. 4, 2011 Annual Congress of the German Society for Hematology and

Oncology (DGHO), Basel, Switzerland

September 17-21, 2011 51th Interscience Conference on Antimicrobial Agents and

Chemotherapy (ICAAC), Chicago, USA

September 1-3, 2011 45th Congress of the German Society for Mycology (DMykG

e.V.), Kiel, Germany

May 7-10, 2011 21st ECCMID/27th ICC, Joint Congress of the

European Society of Clinical Microbiology and Infectious

Diseases and the International Society of Chemotherapy20th,

Milan, Italy

March 31-April 2, 2011 Annual Congress of the German Society for Infectious

Diseases (DGI), Leipzig, Germany

October 1-5, 2010 Annual Congress of the German Society for Hematology and

Oncology (DGHO), Berlin, Germany

September 12-15, 2010 50th Interscience Conference on Antimicrobial Agents and

Chemotherapy (ICAAC), MA, Boston, USA

September 9-11, 2010 44th Congress of the German Society for Mycology (DMykG

e.V.), Vienna, Austria

June 23-26, 2010 10th Congress of Infectious Diseases and Tropical Medicine,

Cologne, Germany

June 18-19, 2010 MSD Workshop „Infektionen in der Hämatologie“, Munich,

Germany

May 7-8, 2010 Paul-Ehrlich-Gesellschaft für Chemotherapie e.V., Spring

Meeting of the “Sektion Antimykotische Chemotherapie”,

Bonn, Germany

April 10-13, 2010 20th European Congress of Clinical Microbiology and

Infectious Diseases (ECCMID), Vienna, Austria


Publications

January 2013 Christopeit M, Lindner A, Surov A, Weber T, Vehreschild MJ,

Bialek R, Schmoll HJ.Right flank pain and high fever in a

neutropenic patient with acute lymphoblastic leukaemia.

Mycoses 2013, Jan; 56(1):90-92

October 2011 de Hoog GS, Robert V, Lackner M, Vehreschild MJ,

Vehreschild JJ, Symoens F, Göttlich-Fligg E, Garcia-Hermoso

D, Harun A, Meyer W, Chen SC, Hamprecht A, Fischer G,

Buzina W, Cornely OA, Guarro J, Cano J, Horré R

Making moulds meet. Information retrieval as a basis for

understanding Pseudallescheria and Scedosporium

Mycoses. 2011 Oct;54 Suppl 3:1-4

December 2009 M.J.G.T. Rüping, W.J. Heinz, A.J. Kindo, V. Rickerts, C. Lass-

Flörl, C. Beisel, R. Herbrecht, Y. Roth, G. Silling, A.J.

Ullmann, K. Borchert, G. Egerer, J. Maertens, G.

Maschmeyer, A. Simon, M. Wattad, G. Fischer, J.J.

Vehreschild, O.A. Cornely

Forty-one Recent Cases of Invasive Zygomycosis from a

Global Clinical Registry

J Antimicrob Chemother. 2010 Feb;65(2):296-302

July 2008 Rüping M.J.G.T., Albermann N., Ebinger F., Burckhard I.,

Beisel C., Müller C., Vehreschild J.J., Kochanek M.,

Fätkenheuer G., Bangard C., Ullmann A.J., Herr W., Kolbe

K., Hallek M., Cornely O.A.

Posaconazole concentrations in the central nervous system.

J Antimicrob Chemother 2008 Dec;62 (6):1468-70

Awards

Young Investigator Award 2010 (Nachwuchsförderpreis) of the German Society for Mycology

(DMykG e.V.) awarded to Dr. M.J.G.T. Vehreschild for her work on Fungiscope

Recent Accomplishments

Launch of new, improved website in March 2013

Initiation of the MSG Phaeohyphomycosis Registry by use of the Fungiscope database

in October 2012.

Manuscript of joint analysis with Brazilian Fusarium spp group (Prof Nucci, Rio de

Janeiro, Brazil) submitted.

Newly established cooperation with the Robert Koch Institute (Dr. Volker Rickerts,

Berlin, Germany) for extended diagnostics on paraffin-embedded specimens of patients with suspected invasive emerging fungal infections by use of sequencing plus ribosomal RNA FISH.

http://www.ncbi.nlm.nih.gov/pubmed/21995656

http://www.ncbi.nlm.nih.gov/pubmed/21995656


Initiation of an analysis of combination treatment with liposomal amphotericin B plus

posaconazole for mucormycosis infections in co-operation with the SEIFEM study group

(Prof. Livio Pagano, Rome, Italy)

Database restructuring including:

o Re-evaluation of all cases with respect to infection vs. colonization

o Harmonizing different wording used for documentation

o Structural adjustments facilitating data export and analysis

Initiation of an epidemiological online survey to monitor trends

Goals for 2013

Publication of a subset analysis on rare yeasts, including resistance patterns

Publication of a comparison between sequencing and morphological results for the first

100 Fungiscope isolates

Extending the FungiQuest™ platform (online since April 2010):

o Faster inclusion of new cases

o Inclusion of FungiThek / isolate information

o Improved search-engine


Contact Information

Chair:

Oliver A. Cornely, MD, FIDSA, FACP

[email protected]

Coordinating Physicians:

Maria J.G.T. Vehreschild (née Rüping), MD

[email protected]

Kerstin Wahlers, MD

[email protected]

Technical advisor, site operator clinicalsurveys.net:

Jörg J. Vehreschild, MD

[email protected]

Uniklinik Köln

Infectious Diseases – Clinical Trials Unit II

BH E15 R64

Kerpener Strasse 62

50937 Köln

Germany

T +49-221-478-6494

F +49-221-478-3611

www.fungiscope.net





http://www.fungiscope.net/


Participating Institutions

Argentina

El Centro de Internación de FUNDALEU, Departamento Medico, Buenos

Aires, Argentina

Maria Cecilia

Dignani

Instituto Nacional de Enfermedades Infecciosas "Dr. C. G. Malbrán",

Buenos Aires, Argentina

Susana

Cordoba

Centro de Referencia de Micología Facultad de Ciencias Bioquímicas y

Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina Marisa Biasoli

Centro de Trasplante de Médula Ósea de Rosario (CETRAMOR), Rosario,

Argentina. José Anibal

Cozzi

Australia

Department of Microbiology & Infectious Diseases, Royal Perth Hospital,

Perth, Australia

Christopher

Heath

Austria

Abt. f. Anästhesie und Intensivmedizin, Wilhelminenspital Wien, Wien,

Austria Peter Wimmer

Anästhesiologie und Intensivmedizin, Landesklinikum Thermenregion

Baden, Baden, Austria

Franz

Schwameis

Infektionen und Tropenmedizin, Universitätsklinik I für Innere Medizin,

Medizinische Universität Wien, Wien, Austria

Christina

Kratzer,

Elisabeth

Presterl

Institut für Anästhesie und Intensivmedizin, Landeskrankenhaus Steyr,

Steyr, Austria

Achim von

Goedecke

Institut für Hygiene, klinische Bakteriologie und Mykologie, Medizinische

Universität Graz, Graz, Austria Walter Buzina

Institut für Hygiene, Mikrobiologie und Sozialmedizin, Medizinische

Universität Innsbruck, Innsbruck, Austria

Cornelia Lass-

Flörl, Anna

Huppert,

Isabella Schalk

Institut für Pathologie, Medizinische Universität Innsbruck, Innsbruck,

Austria Ulrich Strasser

Kinder- Herzzentrum Linz, Allgemeines Krankenhaus Linz, Linz, Austria Werner

Moosbauer

Klinik für Anästhesiologie, Wagner-Jauregg Nervenklinik, Linz, Austria Udo Illievich

Klinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Austria Sebastian Ott

Krankenhaushygiene, Landeskrankenhaus Klagenfurt, Klagenfurt, Austria Ulrich Zerlauth

Section of Infectious Diseases, Department of Medicine, Medical University

of Graz, Austria Martin Hoenigl


Universitätsinstitut für Medizinische Mikrobiologie, Hygiene und

Infektiologie - SALK Labor GmbH, Salzberger Universitätsklinikum,

Salzberg, Austria

Markus Hell

Universitätsklinik für Dermatologie, Medizinische Universität Wien, Wien,

Austria

Katharina

Pfistershammer

Belgium

University Hospital Gasthuisberg , Leuven, Belgium

Katrien Lagrou,

Johan,

Maertens,

Isabel Spriet

Brazil

Hematology and Mycology Laboratory, Hospital Universitário Clementino

Fraga, UFRJ, Rio de Janeiro, Brazil Marcio Nucci

Infection Control Dept., Santa Casa Complexo Hospitalar, Universidade

Federal do Rio Grande do Sul, Brazil

Alessandro

Pasqualotto

Laboratory of Mycology, Hospital das Clinicas, Federal University of

Paraná, Curitiba, Brazil

Flávio de

Queiroz Telles

Serviço de Oncohematologia / TMO, Hospital Univ. Prof. Edgard Santos -

UFBA, Salvador, Bahia, Brazil

Marco Aurélio

Salvino, Monica

Botura

Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil Denise Pereira

Canada

Department of Medicine, Peter Lougheed Center, Calgary, Canada Andrew

Johnson

Departments of Medicine & Microbiology and Immunology, McGill

University, Montreal, Canada Don Sheppard

Microbiology and Infectious Diseases, SMBD - Jewish General Hospital,

Montreal, Canada Mark Miller

Service de Maladies Infectieuses, Département de Pédiatrie, McGill

University, Montreal, Canada

Philipe

Ovetchkine

Laboratoire de santé publique du Quebec, Secteur Mycologie, Sainte-Anne-

de Bellevue (Quebec), Canada

Philippe

Dufresne

Internal Medicine Residency Program, Juravinski Hospital and Cancer

Centre, St. Hamilton/Ontario, Canada Shariq Haider

Medical Microbiology Division of Medical Microbiology and Infection Control

JPPN 1112A Microbiology, Vancouver, Canada Diane Roscoe

Chile

Facultad de Medicina, Universidad de Valparaíso, Chile Thomas

Weitzel

Unidad de Infectología, Clínica Alemana, Santiago de Chile, Chile Luis Thompson


China

Changhai Hospital, Department of Hematology, Shanghai P.R., China Jian-Min Yang

Institute of Hematology, Peking University People's Hospital, Beijing, China Feng-Rong

Wang

Department of Hematology, Guangdong General Hospital, Guangdong,

China Xin Du

Zhejiang University, School of Medicine, The First Affiliated Hospital, Bone

Marrow Transplant Center, Hangzhou Zeijiang, China He Huang

Columbia

Conjunto Residencial Montevideo, Medellin, Columbia

Angela

Restrepo,

Angela Tobón

Croatia

Division of Haematology, Zagreb University Hospital Centre, Zagreb,

Croatia

Nemet Damir,

Vrohvac

Radovan

Cuba

Instituto de Hematologia e Imunologia, Habana, Cuba

Alberto

Arencibia

Núñez

Czech Republic

Dept. of Internal Medicine, Hematology/Oncology, Faculty Hospital Brno,

Brno, Czech Republic Zdenek Racil

Dept. of Microbiology, Faculty of Medicine, Palacky University, Olomouc,

Czech Republic Petr Hamal

Denmark

Dept. of Hematology, Copenhagen University Hospital, Copenhagen,

Denmark

Jannik Helweg-

Larsen, Emil

Hermansen

France

Département d'Hématologie, Hôpital Saint-Louis, Assistance Publique -

Hôpitaux de Paris, and Université Denis Diderot, Paris, France

Emmanuel

Raffoux,

Patricia Ribaud

Hematology and Oncology, University Hospital of Strasbourg Hautepierre

Hospital, Strasbourg, France

Raoul

Herbrecht

Germany


Abteilung für Hämatologie, Onkologie und Rheumatologie,

Universitätsklinikum Heidelberg, Heidelberg, Germany

Johann

Wilhelm Schier

Abteilung für Innere Medizin, Hämatologie u.Onkologie, Klinikum

Frankfurt, Germany Michael Kiehl

Abteilung für Kinder- und Jugendmedizin, Marienhospital Witten, Witten,

Germany

Bahman

Gharavi

Department of Infectious Diseases and Tropical Medicine, Ludwig-

Maximilians-Universität München, Muenchen, Germany

Thomas

Loescher

Dermatologie, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany Gesina Hansel

Division of Clinical Infectious Diseases, Medical Clinic, Research Center

Borstel, Borstel, Germany

Christoph

Lange

Gastroenterologie & Infektiologie, St. Josef Hospital, Klinikum der Ruhr-

Universität Bochum, Bochum, Germany

Renate

Schlottmann

Abt. Hämatologie und Onkologie, Georg-August-Universität, Goettingen,

Germany Silke Neumann

Hämatologie / Internist. Onkologie, Uniklinik Erlangen, Erlangen, Germany Wolf Rösler

Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Potsdam,

Germany

Angelika

Gerhardt,

Georg

Maschmeyer

Hämatologie und Onkologie, Medizinische Klinik I, Kliniken Sindelfingen,

Sindelfingen, Germany

Stefan

Neuburger

Hämatologie und Onkologie, Universitätsklinikum Freiburg, Freiburg,

Germany

Hartmut Bertz,

Werner C.

Neubauer

Hämatologie/Onkologie/Immunologie/Rheumatologie, Klinikum Schwäbisch

Gmünd, Stauferklinik, Mutlangen, Germany Holger Hebart

HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany

Katrin Gollner,

Kathrin

Scheckenbach

II. Medizinische Klinik, Einheit für Stammzelltransplantation, Klinikum

Augsburg, Augsburg, Germany

Christoph

Schmid

III. Medizinische Klinik, Universitätsklinikum Mannheim , Mannheim,

Germany

Dieter

Buchheidt,

Anne Dietz

Infektiologikum Frankfurt, Frankfurt, Germany Gaby Knecht

Institut für Infektiologie, Asklepios Klinik St. Georg, Hamburg, Germany M. Sabranski

Institut für Medizinische Mikrobiologie und Hygiene, Universität Lübeck,

Lübeck, Germany Jan Rupp

Institut für Medizinische Mikrobiologie, Universitätskliniken Göttingen,

Göttingen, Germany Uwe Groß

Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany Claudia

Wickenhauser


Institut für Tropenmedizin, Universitätsklinikum Düsseldorf, Düsseldorf,

Germany Stefan Reuter

Interdisziplinäres Zentrum für Palliativmedizin, Agaplesion Markus

Krankenhaus, Frankfurt am Main, Germany Sabine Mousset

Kinderkardiologie und Pädiatrische Intensivmedizin, Klinikum der

Universität München-Großhadern, München, Germany Markus Loeff

Klinik III für Innere Medizin, Uniklinik Ulm, Ulm, Germany Georg Härter

Klinik f. Hämato-Onkologie, Klinikum Harlaching, Städtisches Klinikum

München GmbH, München, Germany

Meinolf

Karthaus,

Xavier Schiel

Klinik für Anaesthesiologie und Operative Intensivmedizin, Klinikum

Konstanz, Konstanz, Germany

Wolfgang

Krüger

Klinik für Dermatologie, University of Tübingen, Tübingen, Germany

Sybille

Schmidt,

Martin Schaller

Klinik für Hals-, Nasen- und Ohrenheilkunde, Klinikum der Universität

München-Großhadern, München, Germany

Robert

Guerkov

Klinik für Hämatologie und Onkologie, Vivantes Krankenhaus, Berlin,

Germany

Jörg Beyer,

Markus Müller

Klinik für Hämatologie, Onkologie & Palliativmedizin, Städt. Kliniken

Bielefeld gem.GmbH, Bielefeld, Germany Martin Görner

Klinik für Hämatologie, Onkologie und Klin. Immunologie,

Universitätsklinikum Düsseldorf, Düsseldorf, Germany

Thomas

Schröder

Klinik für Hämatologie/Internistische Onkologie und

Stammzelltransplantation, Kliniken Essen Süd, Essen, Germany

Mohammed

Wattad

Klinik für Infektiologie und Tropenmedizin, LMU, München, Germany Thomas

Loescher

Klinik für Innere Medizin IV, Onkologie und Hämatologie, Martin-Luther-

University Halle-Wittenberg, Halle, Germany

Maximilian

Christopeit,

Hans-Heinrich

Wolf

Klinik für Knochenmarktransplantation, Universitätsklinikum Essen, Essen,

Germany

Rudolf

Trenschel

Klinik für Neonatologie, Universität zu Bonn, Bonn, Germany Cornelia Graef

Klinik für Nephrologie, Universitätsklinikum Essen, Essen, Germany Oliver Witzke

Klinik für Neurochirurgie, Charité-Universitätsmedizin Berlin, Berlin,

Germany Olaf Süss

Klinik für Neurologie, Helios-Klinikum Berlin-Buch, Berlin, Germany Franz-Josef

Dieste

Klinik für Innere Medizin II, Sektion Infektiologie, Universitätsklinikum

Jena, Jena, Germany Matthias Pletz

Klinik I für Innere Medizin, Uniklinik Köln, Köln, Germany

Oliver Cornely,

Fedja Farowski,

Maria

Vehreschild,


Jörg Janne

Vehreschild,

Kerstin

Wahlers

Klinik und Poliklinik für Innere Medizin C, Hämatologie und Onkologie -

Transplantationszentrum Universitätsklinikum der Ernst-Moritz-Arndt-

Universität Greifswald, Greifswald, Germany

William Krüger,

Katrin Schulz

Klinik und Poliklinik für Innere Medizin, Abteilung für Hämatologie und

Onkologie, Universitätsklinikum Rostock, Rostock, Germany

Kersten

Borchert, Lena

Diestel, Michael

Schmitt

Klinik und Poliklinik für Orthopädie, Uniklinik Köln, Köln, Germany Rolf Sobottke

Klinik und Poliklinik für Kinderheilkunde – Pädiatrische

Hämatologie/Onkologie - Uniklinik Münster, Münster, Germany

Andreas Groll

Jörg Ritter

Klinikum Dortmund Nord, Abteilung Pneumologie/Infektiologie, Dortmund,

Germany

Bernhard

Schaaf,

Stefanie

Später, Greta

Ullrich

Klinikum Neuperlach, Medizinische Klinik IV, München, Germany Meinolf

Karthaus

Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, Uniklinik

Erlangen, Erlangen, Germany

Stefan Kallert,

Stefan Krause

Medizinische Klinik 5 – Hämatologie und Internistische Onkologie,

University of Witten/Herdecke, Köln, Germany

Stefan

Sauerland

Medizinische Klinik A, KMT-Zentrum, Uniklinik Münster, Münster, Germany Gerda Silling

Medizinische Klinik I, Klinikum Bremen-Mitte, Bremen, Germany Henrike

Thomssen

Medizinische Klinik III, Klinikum der Universität München-Großhadern,

München, Germany

Helmut

Ostermann Lisa

Peterson

Medizinische Klinik und Poliklinik I, Uniklinik Dresden, Dresden, Germany Ulrich Schuler

Medizinische Klinik und Poliklinik II, Charité-Universitätsmedizin Berlin,

Berlin, Germany Markus Ruhnke

Medizinische Klinik und Poliklinik II, Universität Würzburg, Würzburg,

Germany

Werner Heinz,

Jürgen Löffler,

Hartwig

Klinker, Bhanu

Sinha, Andrew

Ullmann

Medizinische Klinik und Poliklinik II, Universitätsklinikum Schleswig-

Holstein, Kiel, Germany Heinz-A. Horst

Medizinische Klinik und Poliklinik V, Universitätsklinikum Heidelberg,

Heidelberg, Germany Gerlinde Egerer


Medizinische Poliklinik, Klinikum der Universität München-Großhadern,

Müuenchen, Germany

Johannes

Bogner

MVZ Labor Dr. Krause und Kollegen, Kiel, Germany Ralf Bialek

Mykologisches Labor, Krankenhaus Dresden-Friedrichstadt, Dresden,

Germany

Irina

Vennewald

Onkologikum Frankfurt, Frankfurt, Germany Angelika

Böhme

Pädiatrische Hämatologie und Onkologie Infektiologie, Zentrum der

Kinderheilkunde, Universität zu Bonn, Bonn, Germany Arne Simon

Rheumatologische Ambulanz, Sana Rheumazentrum Rheinland-Pfalz AG,

Bad Kreuznach, Germany Eckhard Weber

Robert Koch Institut, Abteilung für Infektionskrankheiten,Berlin, Germany

Volker

Rickerts,

Michael Seibold

Universitätsklinikum Freiburg, Freiburg, Germany Helmut Lang

Zentrum für Infektiologie und Reisemedizin, Universitätsklinikum Freiburg,

Freiburg, Germany Dirk Wagner

Zentrum für Kinder- und Jugendmedizin, Klinik III, Klinikum der Johann

Wolfgang Goethe-Universität, Frankfurt am Main, Germany

Thomas

Lehrnbecher

Institut für Hygiene, Kliniken der Stadt Köln, Krankenhaus Merheim, Köln,

Germany Frauke Mattner

Institut für Medizinische Mikrobiologie, Universitätsklinikum Essen, Essen,

Germany Jörg Steinmann

Greece

1st Department of Propaedeutic Medicine, Athens University, Athens,

Greece Anna Skiada

Cystic Fibrosis Department, Aghia Sophia Children´s Hospital, Athens,

Greece

Stavros

Doudounakis

Infectious Diseases and Antimicrobial Chemotherapy Research Laboratory,

Athens University, Athens, Greece

George L.

Petrikkos

Laboratory for Clinical Microbiology, Attikon University General Hospital,

Athens, Greece

Joseph

Meletiadis

Hungary

Department of Microbiology, Faculty of Science and Informatics, University

of Szeged, Szeged, Hungary Lorant Hatvani

Semmelweis University, 1st Clinic for Internal Medicine, Budapest,

Hungary Judit Demeter

India

Department of Medical Microbiology, Postgraduate Institute of Medical

Education & Research, Chandigarh, India

Arunaloke

Chakrabarti

Department of Pulmonary Medicine, Postgraduate Institute of Medical

Education & Research, Chandigarh, India Ritesh Agarwal

Dept. of Microbiology, Centre for Basic Sciences, Kasturba Medical College,

Manipal University, Manipal, India

Prakash

Yegneswaran


Indonesia

Department of Internal Medicine University of Indonesia, Faculty of

Medicine University of Indonesia, Mangunkusumo Hospital, Jakarta,

Indonesia

Erni J Nelwan

Ireland

Dept. of Bacteriology, Belfast City Hospital, Belfast, Ireland John E. Moore

Trinity College, Dublin Saint James Hospital, Dublin, Ireland Thomas Rogers

Israel

Department of Otolaryngology – Head & Neck Surgery, Edith Wolfson

Medical Center, Holon, Israel Yehudah Roth

Hadassah University Medical Center, Jerusalem, Israel Maya Korem

Infectious Diseases Unit, Rabin Medical Center, Petah Tikva, Israel Morad Wattad

Sheba Medical Center Israel, Tel Aviv, Israel Nathan Keller

Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Ronen Ben-Ami

Italy

Department of Biomedical Science and Human Oncology — Hygiene

Section, University of Bari, Bari, Italy

Maria Teresa

Montagna

Dipartimento di Ematologia, Universita Cattolica del Sacro Cuore, Rome,

Italy Livio Pagano

Dipartimento di Farmacologia, Università degli Studi di Firenze, Firenze,

Italy Andrea Novelli

Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San

Martino, Genova, Italy

Andrea

Bacigalupo

Hematology Unit, San Camillo-Forlanini Hospital, Rome, Italy Mariagrazia

Garzia

Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Rome, Italy Maurizio

Sanguinetti

Laboratorio di Micologia Medica, Sezione Sanità Pubblica, University of

Milan, Milan, Italy

Annamaria

Tortorano

Oncoematologia Pediatrica, Policlinico G.B. Rossi, Verona, ItalyClinica di

Oncoematologia Pediatrica, Azienda Ospedaliera Padova, Padova, Italy Simone Cesaro

Pathology Unit, Luigi Sacco Hospital, University of Milan, Milan, Italy Gianluigi Vago

Japan

Division of Control and Treatment of Infectious Diseases, Chiba University

Hospital, Chiba, Japan

Katsuhiko

Kamei, Akira

Watanabe

Nagasaki University Hospital, Nagasaki, Japan Shigeru Kohno

Seirei Hamamatsu General Hospital, Shizuoka, Japan Shinichiro

Morioka

Korea

Department of Hematology-Oncology, Ajou University School of Medicine,

Suwon, Korea

Joon Seong

Park


Hematology-Oncology Clinic, Hematopoietic Stem Cell Transplantation

Center, Center for Specific Organs Cancer, Research Institute and Hospital,

National Cancer Center, Korea

Hyeon Seok

Eom

Kuwait

Microbiology Department, Health Sciences Center, Kuwait, Kuwait Eiman

Mokaddas

Lebanon

American University of Beirut Medical Center, Beirut, Lebanon Souha Kanj-

Sharara

Lithuania

Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania Marius Miglinas

Vilnius University Hospital, Department of Hematology, Vilnius, Lithuania Indre Klimiene

Mexico

Hospital Civil de Guadalajara, Fray Antonio Alcalde, Guadalajara, Jalisco,

Mexico,

Eduardo

Rodriguez-

Noriega

Hospital General de Culiacán, Sinaloa, Mexico Ramón Rivas

Llamas

IXtlamatia Clinical Research S.A. de C.V, Mexico City, Mexico Miguel Ángel

Reséndiz

Netherlands

Department of Medical Microbiology, Canisius-Wilhelmina Hospital,

Nijmegen, Netherlands Jacques Meis

University Medical Center Groningen, Groningen, the Netherlands Jan P. Arends

Peru

Hematology/ BMT Department, Rebagliati National Hospital, Lima, Peru

Eduardo

Fernandez-

Vertiz

Portugal

Coimbra University Hospital, Coimbra, Portugal Rui Tome

Institute of Molecular Pathology and Immunology of the University of

Porto, Porto, Portugal Rita Caramalho

Romania

Department of Mycology-Mycotoxicology, Universitatea Petre Andrei, Iasi,

Romania Mihai Mares

Russia

Department of Clinical Mycology, Allergology and Immunology, St.

Petersburg Medical Academy of Postgraduate Education, St. Petersburg,

Russia

Nikolay Klimko

Sofya

Khostelidi

Serbia

Serbian Society of Medical Mycology (SSMM), National Medical Mycology

Reference Laboratory - NMMRL, Belgrade, Serbia

Valentina Arsic

Arsenijevic

Singapore


Infectious Diseases Care, 03-01 Mount Elizabeth Medical Centre, 228510

Singapore Asok Kurup

National University Health System, University Medicine Center, Division of

Infectious Diseases, NUHS Tower Block, Level 10, 119228 Singapore

Chai Louis Yin

Ann

National University Health System, University Children\'s Medical Institute,

Department of Pediatrics, 119228 Singapore, Singapore Si Min Chan

Slovakia

National Cancer Institute, Bratislava, Slovakia Lubos Drgona

South Africa

Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa Robert Dunn

Nelson R. Mandela School of Medicine, Pretoria, South Africa Teke Apalata

Spain

Department of Hematology, University Hospital La Fe, Valencia, Spain,

Valencia, Spain

Rebeca

Rodriguez

Veiga

Grupo Andaluz de Leucemias Agudas GALA, Hospital Juan Ramón Jiménez-

Huelva, Huelva, Spain

Eusebio Martín

Chacón Servicio de Hematología de la Unidad de Consejo y Cuidado Oncológico de

Sanitas, Hospital de la Princesa, Madrid, Spain

Rafael de la

Cámara

Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del

Rocío, Sevilla, Spain

Martin-Pena

Almudena

Hospital Universitario Marqués De Valdecilla, Department of Hematology,

Santander, Spain

Lucrecia Yanez

San Sugundo

Sweden

Clinical Micrbiological Laboratory, Sunderby Hospital, Luleå, Luleå, Sweden Peter Cettner

Switzerland

Abt. für Spitalhygiene und Spitalepidemiologie, Universitätsspital Basel,

Basel, Switzerland

Andreas

Widmer

Division of Infectious Dieseases & Hospital Epidemiology, Universitätsspital

Basel, Basel, Switzerland U. Flueckiger

Medizin I Abteilung für Hämatologie, Universitätsspital Basel, Basel,

Switzerland Alois Gratwohl

Institut für Infektionskrankheiten, Bern, Switzerland Stefan

Zimmerli

Universitätsklinik für Pneumologie, Inselspital, Universitätsspital Bern,

Bern, Switzerland Sebastian Ott

University Hospital Lausanne (CHUV), Lausanne, Switzerland Andrej Trampiz

Taiwan

Far Eastern Memorial Hospital, Taipei, Taiwan Chiaying Liu

Tai-Chen Stem Cell Therapy Center, National Taiwan University, Taipeh,

Taiwan Jih-Luh Tang

Division of Infectious Diseases, Department of Internal Medicine, Center

For Infection Control, National Taiwan University Hospital, Taipei, Taiwan Yee-Chun Chen

Thailand


Division of Infectious Diseases and Tropical Medicine, Khon Kaen

University, Khon Kaen, Thailand

Ploenchan

Chetchotisakd

Turkey

Akdeniz University Medical Faculty, Department of Clinical Microbiology,

Antalya, Turkey Dilara Ogunc

Department of Medicine, Section of Infectious Diseases, Hacettepe

University Medical School, Ankara, Turkey

Murat Akova,

Sevtap Arikan,

Omrun Uzun

Division of Hematology, Dokuz Eylul University Faculty of Medicine, Izmir,

Turkey Fatih Demirkan

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Baskent

University, Ankara, Turkey Can Boga

Beyoglu Eye Training and Research Hospital, Istanbul, Turkey Serhat

Imamoglu

Dokuz Eylul University Hospital, Department of Hematology, Izmir, Turkey Omur Gokmen

Sevindik

United Kingdom

Department of Infection, St George's University of London, London, United

Kingdom Jon Lambourne

NPHS Microbiology ABM (Swansea and Bridgend), Wales, United Kingdom Nidhika Berry

Princess Royal University Hospital, South London Healthcare NHS Trust,

Farnborough Common, Orpington, Kent, United Kingdom

M. Mansour

Ceesay

Southern General Hospital, Glasgow, United Kingdom Nitish Khanna

USA

Department of Infectious Diseases, Section of Transplant Infectious

Diseases, Medicine Institute and Transplant Center, Cleveland Clinic Lerner

College of Medicine of Case Western University, Cleveland, Ohio, USA

Sherif

Beniameen

Mossad

Department of Pathology, University of Colorado, Denver, USA Diane

Hutchinson

Division of Infectious Diseases, University of Washington Office,

Washington, USA Philip Coffin

University of Alabama at Birmingham, Birmingham, USA John Baddley

University of Texas Southwestern Medical Center at Dallas, Dallas, USA Sanjay

Revankar

Medical Microbiology Division, Department of Pathology, University of Iowa

College of Medicine, Iowa City, IA, USA Linda Boyken

MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana,

USA

Patricia

Connolly

Division of Medical Microbiology, Department of Pathology The Johns

Hopkins University School of Medicine, Baltimore, MD, USA Sean Zhang

Division of Infectious Diseases Director, Microbiology & Infectious Diseases

Translational Research Center Henry Ford Hospital, Wayne State University

School of Medicine, Detroit, MI

Jose. A

Vasquez

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