git pathogenic bacteria

7/29/2019 Git Pathogenic Bacteria

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Food borne Pathogenic Bacteria

Riyani Wikaningrum

Bag. MikrobiologiFK Universitas YARSI


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The GIT defense

mechanisms


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Terminologies Gastroenteritis

A syndrome characterized by gastrointestinal symptoms including

nausea, vomiting, diarrhea and abdominal discomfort

Diarrhea

Abnormal fecal discharge characterized by frequent and/or fluid stool;

usually resulting from disease of the small intestine and involvingincreased fluid and electrolyte loss

Dysentery

An inflammatory disorder of the gastrointestinal tract often associated

with blood and pus in the feces and accompanied by symptoms of

pain, fever, abdominal cramps; usually resulting from disease of thelarge intestine

Enterocolitis

Inflammation involving the mucosa of both the small and large

intestine


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Results of GIT Infections

Pharmacologic action of bacterial toxins, local or

distant to site of infection

e.g. cholera, staphylococcal food poisoning

Local inflammation in response to superficial

microbial invasion e.g. shigellosis, amebiasis

Deep invasion to blood or lymphatics; dissemination

to other body sites

e.g. Hepatitis A, enteric fevers

Perforation of mucosal epithelium after infection,

surgery or accidental trauma

e.g. peritonitis, intra-abdominal abscesses


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Pathogenic Bacteria

Salmonella spp.

Clostridium botulinum

Staphylococcus aureus

Campylobacter jejuni

Yersinia enterocolitica Yersinia pseudotuberculosis

Listeria monocytogenes

Vibrio cholerae O1

Vibrio cholerae non-O1 Vibrio parahaemolyticus

and other vibrios

Vibrio vulificus

Clostridium perfringens

Bacillus cereus

Aeromonas hydrophila andother spp.

Plesiomonas shigelloides

Shigella sp.

Miscellaneous enterics

Streptococcus

Clostridium difficile
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GIT

Infections


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Dapat ditemukan sebagai flora normal usus

Penyebab pseudomembraneus colitis, diare

akibat pemakaian antibiotik (AAD)

Menghasilkan:

toxin yang bersifat sitopatik

Enterotoxin

Diagnosis berdasarkan ditemukannya

cytotoxin dalam feses.


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C. d iff ic i le

o After antibiotic use

o Intestinal normal flora

greatly decreased

o Colonization occurs

o Enterotoxin secretedo Pseudomembanous

colitis


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Antibiotic-associated colitis due to Clostridium difficile. Sigmoidoscopic view

showing multiple pseudomembranous lesions


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Pseudomembranous Coli t is

Pseudomembranous colitis (PC) results

predominantly as a consequence of the

elimination of normal intestinal flora through

antibiotic therapy. Symptoms:

include abdominal pain

watery diarrhea and leukocytosis

"Pseudomembranes" consisting of fibrin, mucus andleukocytes endoscopy

Untreated pseudomembranous colitis fatal in

about 27-44%.


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Therapy

Discontinuation of initial antibiotic

(e.g. ampicillin)

Specific antibiotic therapy (e.g.

vancomycin)

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