Guidelines for Information About Therapy Experiments

(GIATE)

Alejandra González Beltrán1

Joint work with Richard Begent2 and May Yong2

1UCL Computational and Systems Medicine2UCL Cancer Institute

2nd MIBBI WorkshopNovember 30th to December 3rd, 2010

Ruedesheim/Rhein, Germany

GIATE – Scope: therapy experiments across many levels supporting translational research

GIATE framework: links different levels, resources, standards Experiment design: target, agent Experimental models

Molecular E.g. protocol, dose regimen, bond study, agent distribution study

Cellular E.g. cell culture conditions, genetic/epigenetic profile, distribution studies

Animal E.g. organism, developmental stage, genetic/epigenetic profile, pharmacokinetics and

pharmacodynamics studies, outcomes

Clinical E.g. eligibility and exclusion criteria, genetic/epigenetic profiles, pharmacokinetics and

pharmacodynamics studies, outcomes

GIATE - Level of Implementation – Initial phase

Adopted by the Antibody SocietyGIATE checklistGIATE classification scheme: list of CDEs, caDSR, NCItGIATE-Tab: spreadsheetGIATE websiteGIATE use casesGIATE ontologyGIATE information into RDFGIATE on the ISA infrastructure

GIATE – Status, Contributors, Funding

Contributors: GIATE resources: Dr May Yong, Prof Richard Begent, Dr

Alejandra Gonzalez-BeltranGIATE use cases: Dr Alan Green, Gairin Dancey

FundingCRUK, NIHR, EPSRC, MRC: UCL Experimental Cancer

Medicine Centre, UCL and KCL Comprehensive Cancer Imaging Centre

Computational and Systems Medicine project, MRC grant G0802528 “Translational Research Initiative”

Thank you!