giant nonfamilial left atrial myxoma presenting with eye embolism and nonvalvular streptococcus...

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IMAGES IN CARDIOLOGY Giant Nonfamilial Left Atrial Myxoma Presenting With Eye Embolism and Nonvalvular Streptococcus sanguinis Endocarditis Diana M. Laura, BA, Adriana Quiñones, MD, Ricardo Benenstein, MD, Didier F. Loulmet, MD, William J. Cole, MD, Dellis A. Galloway, MD, James H. Suh, MD, Muhamed Saric, MD, PHD New York, New York A 64-year-old man developed a 3-month history of recurrent fatigue, fevers, and leukocytosis after teeth cleaning. A year earlier, he had experienced sudden vision loss in the left eye, believed to be nonarteritic anterior ischemic neuropathy. Two-dimensional (2D) and 3-dimensional (3D) transthoracic and transesophageal echocardi- ography revealed a shaggy, highly mobile, 13.0 1.5 cm sausage-like mass in the left heart (A and B, Online Video 1). The mass prolapsed intermittently through the mitral valve into the left ventricle and was tethered to the interatrial septum near the fossa ovalis (C and D, Online Videos 2 and 3). Neither signicant mitral regurgitation nor mitral stenosis was observed. Blood cultures grew Streptococcus sanguinis. The patient underwent surgical removal of the mass (E, Online Video 4). Histopathology revealed left atrial myxoma superinfected with S sanguinis. Despite the giant tumor size and its plop through the mitral valve, the myxoma was clinically silent until it led to subacute nonvalvular infective endocarditis and likely prior ocular embolism. From New York University Langone Medical Center, New York, New York. Manuscript received November 27, 2013; accepted December 3, 2013. Journal of the American College of Cardiology Vol. 63, No. 19, 2014 Ó 2014 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc. http://dx.doi.org/10.1016/j.jacc.2013.12.059

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Page 1: Giant Nonfamilial Left Atrial Myxoma Presenting With Eye Embolism and Nonvalvular Streptococcus sanguinis Endocarditis

From New York University

Langone Medical Center,

New York, New York.

Manuscript received

November 27, 2013;

accepted December 3, 2013.

Journal of the American College of Cardiology Vol. 63, No. 19, 2014� 2014 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00Published by Elsevier Inc. http://dx.doi.org/10.1016/j.jacc.2013.12.059

IMAGES IN CARDIOLOGY

Giant Nonfamilial Left Atrial MyxomaPresenting With Eye Embolism andNonvalvular Streptococcus sanguinis EndocarditisDiana M. Laura, BA, Adriana Quiñones, MD, Ricardo Benenstein, MD, Didier F. Loulmet, MD,

William J. Cole, MD, Dellis A. Galloway, MD, James H. Suh, MD, Muhamed Saric, MD, PHD

New York, New York

64-year-old man developed a 3-month history of recurrent fatigue, fevers, and

Aleukocytosis after teeth cleaning. A year earlier, he had experienced sudden vision loss in

the left eye, believed to be nonarteritic anterior ischemic neuropathy.Two-dimensional (2D) and 3-dimensional (3D) transthoracic and transesophageal echocardi-

ography revealed a shaggy, highly mobile, 13.0 � 1.5 cm sausage-like mass in the left heart (A andB, Online Video 1). The mass prolapsed intermittently through the mitral valve into the leftventricle and was tethered to the interatrial septum near the fossa ovalis (C and D, Online Videos2 and 3). Neither significant mitral regurgitation nor mitral stenosis was observed. Blood culturesgrew Streptococcus sanguinis.

The patient underwent surgical removal of the mass (E, Online Video 4). Histopathologyrevealed left atrial myxoma superinfected with S sanguinis. Despite the giant tumor size andits plop through the mitral valve, the myxoma was clinically silent until it led to subacutenonvalvular infective endocarditis and likely prior ocular embolism.