gfs chemicals triple bond organics
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GFS Chemicals - Innovation and Commercialization through Chemistry - Specialty Organic Chemical ManufacturingTRANSCRIPT
GFS Chemicals, Inc.Innovation and Commercialization through Chemistry ISO 9001:2008 Certified
• Supporting Major Industry Around the Globe• Flexible Production Capabilities for over 80 years• Batch Manufacturing for R&D through Commercialization• Organic and Inorganic Manufacturing Expertise• Semi-Custom Chemistry to Meet Customer Specifications• Problem Solving Chemists Complement Your Project Team• Manufacturing High Quality Chemicals up to metric tons• Exceedingly Responsive to Customer Inquiries• Achieving Accurate and Reliable Production Deadlines
GFS Corporate Story
Industries Served
• Environmental• Semiconductor• Pharmaceutical• Flavor & Fragrance• Superconductivity• Petrochemical• Agricultural• Automotive• Defense • Biotechnology• Power and Energy (Fuel
Cells, Batteries, etc)
Industries Served
• Electronics• Chemicals• Aerospace• Polymers• Coatings• Catalysts• Optics• Contract Manufacturing• Water treatment and
Analysis• Beverage/Dairy• Quality Control Laboratories
Innovation and Growth1928 1940’s 1960’s 1970’s 1980’s
Founded, Columbus Ohio. Perchlorate salts defined early business
Development of trace metal acids (ppt grade acid)
Rare Earth products introduced (CAN) Development of heteroaromatic ligands
Acquisition of Karl Fischer product line
Collaboration on first chrome etchants
Innovation and Growth
Heavy acquisition period includes quaternary salts, sodium biphenyl & Farchan acetylenics
Perchloric acid plant built($2.5M US)
ISO 9000 certification
Aquisition of APS Analytical Standards for turbidimeters, colorimeters and spectrophotomers
New organic production facility built ($3.5M US)
1990’s 1997 1997 2001 2003
Innovation and Growth
Perchloric Acid expansionInorganic and Organic research labs built
UDRI Chrome IV Replacement Project
Beta Phase Tri-Calcium Phosphate - Artificial Bone Scaffold
Purchase of Catalog Distribution Center, Private Labelling Operation and Laboratory Reagents Manufacturing
SOCMA Chem Steward Tier II Certification Ammonia Borane Manufacturing Partnership
2004 2007 2008 2009 2010
Safety and Environment
• GFS is a Tier II Chem Stewards organization focused on safety improvement practices and waste minimization, recovery policies and controls
• Selected Employees are DOT, IATA and IMO certified to support all modes of material logistics to ensure safe and legal shipments world wide.
Compliance and Quality
• GFS organic production operations are a zero discharge facility compliant with all local and federal EPA regulations
• We adhere to ISO 9001:2008 standards for quality practices and have been ISO certified since 1997
Organic Manufacturing
Leaders in the development and commercialization of specialty alkynes and derivatives
Product Offering
• GFS Chemicals remains focused on a core set of synthetic methodologies
• In support of alkyne production, we offer down
stream intermediates such as olefins, heteroaromatics and heterocycles
• We offer over 2000 organic chemicals in our product base
Core Synthetic Chemistry
Na & Li/Liquid Ammonia Chemistry– Alkylations– Aminations– Reductions (Birch, trans)– Ethynylations
Halogenations– Brominations– Chlorinations– Iodinations
Core Synthetic Chemistry
Alkyne Chemistry– Eliminations– Ethynylations– Sonogashira– Glaser Coupling– Cadiot-Chodkiewicz– Click Chemistry
Core Synthetic Chemistry
• Organometallic Chemistry– Grignard– Alkyl lithium– Coupling (Suzuki, Stille,
Negishi, Kumada)– Heck Reaction– LI/NA Amide– Cis-reductions
Core Synthetic Structures
• Alkynes– Aromatic– Terminal– Internal– Alcohols– Ketones– Acids– Conjugated
• Olefins– Cis/trans– En-yne– Cyclic– Grignards– Vinyl– Aryl– Alkyl
Core Synthetic Structures
• Halogenated Organics– Alkynes – Olefins– Alkyl– Aromatic
• Heteroaromatic– Quinolines – Indoles– Pyrimidines– Bipyridines– Phenanthrolines– Terpyridines
Core Synthetic Methodologies
• Alkyne Chemistry• Birch Reductions• Halogenation• Dehydrohalogenation• Alkylation(NH3 or other)• Sonogashira Reactions• Kumada Couplings• Cadiot-Chodkiewicz• Suzuki Coupling
• Diels-Alder Synthesis• Trans Reductions(NH3)• Barbier Reaction• Skraup Synthesis• Heck Reaction• Grignard/Alkyl Lithium
Synthesis• Finklestein Reaction• Phase Transfer
Kilo Lab Operations
• Multiple bench top operation• Glassware up to 72 L scale• Distillation support up to 50L scale
– Short path• Bench Strip• Rotary Evaporators
– Long path• 18” to 48” packed columns• Stainless, Hastelloy, Ceramic
packing
Pilot Scale Operations
– 10 gal – 100 gal Glass– 10 gal – 200 gal Stainless– Distillation Support
– Rotary Evaporator– 30 gal – 50 gal glass
lined steel distillation pots– 4’ to 12’ columns– Glass, Stainless &
Hastelloy packing
Plant Operations
– 350-500 gal Hastelloy– 100-1000 gal Glass – 200-1000 gal Stainless– Distillation support
• Short path– 50 gal-500 gal glass lined
• Long path– 4’ to 16’ column– Stainless, Hastelloy, Glass
packing– Solids Handling
• Hastelloy and Stainless centrifugation
Common Bulk Raw Materials
• Acetylene• Ammonia,liq.• Alkyllithium• Carbon disulfide• Chloroformates• Chlorosulfonic acid• Epichlorohydrin• Ethylene oxide• Bromine
• Lithium amide • Lithium metal• Magnesium• Sodium amide• Sodium hydride • Sodium metal• Trialkylsilanes• Iodine• Hydrogen Chloride
Robust Distillation Capabilities
• Increased capacity:– Single pass distillation– Fractional distillation
• High vacuum capability• Wiped film distillation for heat-
sensitive compounds• Extensive glass equipment for
handling corrosives• Low trace metal impurities
Inorganic Bulk Manufacturing
U.S. Based Inorganic Product Development and Manufacturing
Inorganic Specialties
• Perchloric acid & Salts• Ceric Ammonium Nitrate (Etchants & Catalysis)• Purified compounds for metal complexes• Ultra dry salts for moisture sensitive applications• Rare Earths, Lithium, Sodium and Magnesium salts
& solutions• Precious metal ion exchange resins
Bulk Inorganic Salts
• Nitrates • Sulfates• Chlorides• Perchlorates• Carbonates• Periodates
• Oxalates• Acetates• Formates• Phosphates• Citrates
GFS Catalog Operations
• 70,000 Sq Ft. Operation, Manufacturing and Distribution Center
• Repack and Fulfillment Center• Private Label Operation• Amco Clear Water Analysis Division• Bottling Operations• Quality Control Labs• Manufacturing and Sourcing over 4000
Analytical Reagents
In-House Quality Control Support
• Full wet chemistry lab• HPLC• GC (multiple)• GC/MS• UV/Vis• Karl Fischer• FTIR• Melting & Boiling
Point
• pH & Conductivity• Coulometric Karl
Fischer• Volumetric Karl Fischer• Ion Chromatography• ICP• AA
Customer Metrics
• Inventory Availability • Lead Time Accuracy• Product Quality• Timely Delivery• Product Information/Knowledge• Customer Satisfaction
International Operations
• Sourcing Operations in Beijing China• Serving over 80 countries
worldwide• www.GFSInternational.com
– Japanese– German– French– Spanish